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Publications:  Dr Hannah Heywood

Heywood HK, Caton PW, Lee DA (2016). SIRT1, an enzyme vital to cartilage homeostasis, is regulated by osmolarity and glucose levels. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 97, A2-A2.
Heywood HK, Lee DA(2016). Bioenergetic reprogramming of articular chondrocytes by exposure to exogenous and endogenous reactive oxygen species and its role in the anabolic response to low oxygen. Journal of Tissue Engineering and Regenerative Medicine vol. 11, (8) 2286-2294.
10.1002/term.2126
https://qmro.qmul.ac.uk/xmlui/handle/123456789/11136
Heywood HK, Lee DA (2014). Reactive oxygen species drive the transformation to an oxidative energy metabolism in cultured articular chondrocytes. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 95, A15-A16.
Heywood HK, Nalesso G, Lee DA, Dell'accio F(2014). Culture expansion in low-glucose conditions preserves chondrocyte differentiation and enhances their subsequent capacity to form cartilage tissue in three-dimensional culture. Biores Open Access vol. 3, (1) 9-18.
10.1089/biores.2013.0051
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12684
Pattappa G, Thorpe SD, Jegard NC, Heywood HK, de Bruijn JD, Lee DA(2013). Continuous and uninterrupted oxygen tension influences the colony formation and oxidative metabolism of human mesenchymal stem cells. Tissue Eng Part C Methods vol. 19, (1) 68-79.
10.1089/ten.TEC.2011.0734
https://qmro.qmul.ac.uk/xmlui/handle/123456789/36242
Gammon L, Biddle A, Heywood HK, Johannessen AC, Mackenzie IC(2013). Sub-sets of cancer stem cells differ intrinsically in their patterns of oxygen metabolism. PLoS One vol. 8, (4)
10.1371/journal.pone.0062493
https://qmro.qmul.ac.uk/xmlui/handle/123456789/5099
Pattappa G, Heywood HK, de Bruijn JD, Lee DA(2011). The metabolism of human mesenchymal stem cells during proliferation and differentiation. J Cell Physiol vol. 226, (10) 2562-2570.
10.1002/jcp.22605
Martyn SV, Heywood HK, Rockett P, Paine MD, Wang MJ, Dobson PJ, Sheard SJ, Lee DA et al.(2011). Electrospray deposited fibronectin retains the ability to promote cell adhesion. J BIOMED MATER RES B vol. 96B, (1) 110-118.
10.1002/jbm.b.31745
Pattappa G, Heywood HK, de Bruijn JD, Lee DA(2010). The metabolism of human mesenchymal stem cells during proliferation and differentiation. J Cell Physiol
10.1002/jcp.22605
Heywood HK, Knight MM, Lee DA(2010). Both superficial and deep zone articular chondrocyte subpopulations exhibit the Crabtree effect but have different basal oxygen consumption rates. J Cell Physiol vol. 223, (3) 630-639.
10.1002/jcp.22061
Heywood HK, Lee DA(2010). Low oxygen reduces the modulation to an oxidative phenotype in monolayer-expanded chondrocytes. J Cell Physiol vol. 222, (1) 248-253.
10.1002/jcp.21946
Heywood HK, Lee DA(2008). Monolayer expansion induces an oxidative metabolism and ROS in chondrocytes. Biochem Biophys Res Commun vol. 373, (2) 224-229.
10.1016/j.bbrc.2008.06.011
Heywood HK, Lee DA(2008). The effect of oxygen supply on chondrocyte metabolic phenotype during monolayer culture. European Cells and Materials vol. 16, (SUPPL. 3)
Heywood HK, Lee DA (2007). Development of an immunoassay for determination of adsorbed fibronectin levels on bio-functionalised substrates. TISSUE ENGINEERING. vol. 13, 1669-1670.
Heywood HK, Bader DL, Lee DA (2006). Glucose concentration and medium volume influence cell viability and glycosaminoglycan synthesis in chondrocyte-seeded alginate constructs. Tissue Eng. vol. 12, 3487-3496.
10.1089/ten.2006.12.3487
Heywood HK, Bader DL, Lee DA(2006). Rate of oxygen consumption by isolated articular chondrocytes is sensitive to medium glucose concentration. J Cell Physiol vol. 206, (2) 402-410.
10.1002/jcp.20491
Wang MJ, Heywood HK, Bader DL, Paine MD, Stark JPW, Lee DA(2005). Identification and characterization of deposited fibronectin on biocompatible materials: Comparison of electrospray and wetting methods. Proceedings of the 2005 Summer Bioengineering Conference vol. 2005, 439-440.
Sengers BG, Heywood HK, Lee DA, Oomens CWJ, Bader DL(2005). Nutrient utilization by bovine articular chondrocytes: a combined experimental and theoretical approach. J Biomech Eng vol. 127, (5) 758-766.
10.1115/1.1993664
Heywood HK, Bader DL, Lee DA(2005). Superficial and deep chondrocyte subpopulations both express the crabtree effect but exhibit differences in oxygen consumption rate. European Cells and Materials vol. 10, (SUPPL.2)
Heywood HK, Bader DL, Lee DA (2005). Glucose metabolism of chondrocytes in tissue-engineered alginate constructs. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 86, A13-A14.
Heywood HK, Sembi PK, Lee DA, Bader DL(2004). Cellular utilization determines viability and matrix distribution profiles in chondrocyte-seeded alginate constructs. Tissue Eng vol. 10, (9-10) 1467-1479.
10.1089/ten.2004.10.1467
Heywood HK, Bader DL, Bongers M, LEE DA (2004). Glucose depletion induces an upregulation of oxygen utilisation by chondrocytes. Trans. Orthop. Res. Soc.. Conference: 50th Annual Meeting of the Orthopaedic Research Society vol. 29, 261-261.
Heywood HK, DeRosa E, LEE DA, Bader DL, Netti P (2004). Non-invasive monitoring of molecular diffusion in neo-cartilage using FRAP technique. Trans. Orthop. Res. Soc.. Conference: 50th Annual Meeting of the Orthopaedic Research Society vol. 29, 531-531.
LEE DA, Heywood HK, Baaijens FPT, Oomens CWJ, Sengers BG(2003). Experimental and theoretical analysis of glucose dependent oxygen utilization by bovine articular chondrocytes. Internat. J. Artificial Organs vol. 26, 875-875.
Heywood HK, LEE DA, Bader DL (2002). Monitoring neo-cartilage formation in cell seeded alginate constructs of clinically relevant dimensions. Eur. Cells Materials. Conference: TCES 2002 Annual meeting of the UK Tissue and Cell Engineering Society (Glasgow, Scotland) from: 19/09/2002 to: 20/09/2002, vol. 4 suppl 2, 1-2.
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