Publications: Prof Adina Michael-Titus

Valero-Hernandez E, Tremoleda JL, Michael-Titus AT ( 2024 ) . Omega-3 Fatty Acids and Traumatic Injury in the Adult and Immature Brain . Nutrients vol. 16 , ( 23 )

Campos J, Sampaio-Marques B, Santos D, Barata-Antunes S, Ribeiro M, Serra SC, Pinho TS, Canto-Gomes J et al. ( 2024 ) . Lipid Priming of Adipose Mesenchymal Stromal Cells with Docosahexaenoic Acid: Impact on Cell Differentiation, Senescence and the Secretome Neuroregulatory Profile . Tissue Engineering and Regenerative Medicine1 - 16 .

Shah DK, Ponnusamy V, Evanson J, Kapellou O, Ekitzidou G, Gupta N, Clarke P, Michael-Titus AT et al. ( 2024 ) . Corrigendum: Raised plasma neurofilament light protein levels are associated with abnormal MRI outcomes in newborns undergoing therapeutic hypothermia . Frontiers in Neurology vol. 15 ,

Al-Khateeb ZF, Henson SM, Tremoleda JL, Michael-Titus AT ( 2024 ) . The Immune Response in Two Models of Traumatic Injury of the Immature Brain . Cells vol. 13 , ( 19 )

Nessel I, Whiley L, Dyall SC, Michael-Titus AT ( 2024 ) . A plasma lipid signature in acute human traumatic brain injury: Link with neuronal injury and inflammation markers . Cerebrovascular and Brain Metabolism Reviews ( Immediate Access )

Yip PK, Pizzasegola C, Gladman S, Biggio ML, Marino M, Jayasinghe M, Ullah F, Dyall SC et al. ( 2024 ) . Correction: The Omega-3 Fatty Acid Eicosapentaenoic Acid Accelerates Disease Progression in a Model of Amyotrophic Lateral Sclerosis . PLOS ONE vol. 19 , ( 7 )

Ingram R, Volianskis R, Georgiou J, Jane DE, Michael-Titus AT, Collingridge GL, Volianskis A ( 2024 ) . Incremental induction of NMDAR-STP and NMDAR-LTP in the CA1 area of ventral hippocampal slices relies on graded activation of discrete NMDA receptors . Philosophical Transactions of the Royal Society B Biological Sciences vol. 379 , ( 1906 ) 20230239 - 20230239 .

Al-Khateeb ZF, Boumenar H, Adebimpe J, Shekerzade S, Henson SM, Tremoleda JL, Michael-Titus AT ( 2024 ) . The cellular senescence response and neuroinflammation in juvenile mice following controlled cortical impact and repetitive mild traumatic brain injury . Experimental Neurology vol. 374 ,

Broersen LM, Guida S, Cetinyurek-Yavuz A, van Wijk N, van Helvoort A, Michael-Titus AT, Lansink M ( 2023 ) . Stroke patients have lower blood levels of nutrients that are relevant for recovery: a systematic review and meta-analysis . Frontiers in Stroke vol. 2 ,

Broersen LM, Guida S, Yavuz AC, van Wijk N, van Helvoort A, Michael-Titus AT, Lansink M ( 2023 ) . FOR RECOVERY IN STROKE PATIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS . Clinical Nutrition ESPEN vol. 58 ,

Yip PK, Bremang M, Pike I, Ponnusamy V, Michael-Titus AT, Shah DK ( 2023 ) . Newborns with Favourable Outcomes after Perinatal Asphyxia Have Upregulated Glucose Metabolism-Related Proteins in Plasma . Biomolecules vol. 13 , ( 10 )

Dyall SC, Nessel I, Sharpe JA, Yip PK, Michael-Titus AT, Shah DK ( 2023 ) . Long-chain omega-3 polyunsaturated fatty acids are reduced in neonates with substantial brain injury undergoing therapeutic hypothermia after hypoxic–ischemic encephalopathy . Frontiers in Neurology vol. 14 ,

Campos JD, Santos DJ, Barata-Antunes S, Serra S, Pinho T, Ribeiro J, Marote A, Michael-Titus A et al. ( 2023 ) . OMEGA-SEC: PRIMING ADIPOSE-TISSUE MESENCHYMAL STEM CELLS SECRETOME WITH DOCOSAHEXAENOIC-ACID FOR REGENERATIVE MEDICINE APPLICATIONS IN THE CENTRAL NERVOUS SYSTEM . CYTOTHERAPY . vol. 25 , S42 - S43 .

Perez-Ternero C, Pallier PN, Tremoleda JL, Delogu A, Fernandes C, Michael-Titus AT, Hobbs AJ ( 2022 ) . C-type natriuretic peptide preserves central neurological function by maintaining blood-brain barrier integrity . Frontiers in Molecular Neuroscience vol. 15 ,

Thau-Zuchman O, Pallier PN, Savelkoul PJM, Kuipers AAM, Verkuyl JM, Michael-Titus AT ( 2022 ) . High phenylalanine concentrations induce demyelination and microglial activation in mouse cerebellar organotypic slices . Frontiers in Neuroscience vol. 16 ,

Pradelli L, Adolph M, Calder PC, Deutz NE, Carmona TG, Michael‐Titus AT, Muscaritoli M, Singer P ( 2022 ) . Commentary on “Guidelines for the provision of nutrition support therapy in the adult critically ill patient: The American Society for Parenteral and Enteral Nutrition” . Journal of Parenteral and Enteral Nutrition vol. 46 , ( 6 ) 1226 - 1227 .

Teoh L, Ihalage AA, Harp S, Al-Khateeb ZF, Michael-Titus AT, Tremoleda JL, Hao Y ( 2022 ) . Deep learning for behaviour classification in a preclinical brain injury model . PLOS ONE vol. 17 , ( 6 )

Gala AAD, Kumar H, Sedani S, Openshaw-Lawrence N, Verkuijl JM, Glogowski N, Steingold A, Ponnusamy V et al. ( 2022 ) . Alterations in the Stool Microbiome in Newborns Undergoing Mild Therapeutic Hypothermia after Hypoxic-Ischemic Encephalopathy . Developmental Neuroscience vol. 44 , ( 4-5 ) 373 - 383 .

Brandt MJV, Nijboer CH, Nessel I, Mutshiya TR, Michael‐titus AT, Counotte DS, Schipper L, van der Aa NE et al. ( 2022 ) . Nutritional supplementation reduces lesion size and neuroinflammation in a sex‐dependent manner in a mouse model of perinatal hypoxic‐ischemic brain injury . Nutrients vol. 14 , ( 1 )

Guesne S, Connole L, Kim S, Motevalli M, Robson L, Michael-Titus AT, Sullivan A ( 2021 ) . Umbelliferyloxymethyl phosphonate compounds-weakly binding zinc ionophores with neuroprotective properties . Dalton Transactions vol. 50 , ( 46 ) 17041 - 17051 .

Nixon R, Ip THR, Jenkins B, Yip PK, Clarke P, Ponnusamy V, Michael-Titus AT, Koulman A et al. ( 2021 ) . Lipid Profiles from Dried Blood Spots Reveal Lipidomic Signatures of Newborns Undergoing Mild Therapeutic Hypothermia after Hypoxic-Ischemic Encephalopathy . Nutrients vol. 13 , ( 12 )

France G, Volianskis R, Ingram R, Bannister N, Rothärmel R, Irvine MW, Fang G, Burnell ES et al. ( 2021 ) . Differential regulation of STP, LTP and LTD by structurally diverse NMDA receptor subunit-specific positive allosteric modulators . Neuropharmacology vol. 202 ,

Ponnusamy V, Ip RTH, Mohamed MAEK, Clarke P, Wozniak E, Mein C, Schwendimann L, Barlas A et al. ( 2021 ) . Neuronal let-7b-5p acts through the Hippo-YAP pathway in neonatal encephalopathy . Communications Biology vol. 4 , ( 1 )

Baumard L, Weerts ZZRM, Masclee AAM, Keszthelyi D, Michael-Titus AT, Peiris M ( 2021 ) . Effect of Obesity on the Expression of Nutrient Receptors and Satiety Hormones in the Human Colon . Nutrients vol. 13 , ( 4 )

Thau-Zuchman O, Svendsen L, Dyall SC, Paredes-Esquivel U, Rhodes M, Priestley JV, Feichtinger RG, Kofler B et al. ( 2021 ) . A new ketogenic formulation improves functional outcome and reduces tissue loss following traumatic brain injury in adult mice . Theranostics vol. 11 , ( 1 ) 346 - 360 .

Baumard L, Weerts ZZ, Masclee A, Keszthelyi D, Michael-Titus A, Peiris M ( 2021 ) . Effect of obesity on the expression of nutrient receptors and satiety hormones in the human colon . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 33 ,

Gaviria M, Celeghin A, Michael-Titus AT, Pallier PN ( 2020 ) . Editorial: Brain Plasticity and Contribution of the Emotional Brain to Neural Remodelling After Injury . Frontiers in Neurology vol. 11 , 606271 - 606271 .

Shah DK, Yip PK, Barlas A, Tharmapoopathy P, Ponnusamy V, Michael-Titus AT, Chisholm P ( 2020 ) . Raised Plasma Neurofilament Light Protein Levels After Rewarming Are Associated With Adverse Neurodevelopmental Outcomes in Newborns After Therapeutic Hypothermia . Frontiers in Neurology vol. 11 ,

Nessel I, Michael-Titus AT ( 2020 ) . Lipid profiling of brain tissue and blood after traumatic brain injury: A review of human and experimental studies . Seminars in Cell and Developmental Biology

Zirpoli H, Chang CL, Carpentier YA, Michael-Titus AT, Ten VS, Deckelbaum RJ ( 2020 ) . Novel Approaches for Omega-3 Fatty Acid Therapeutics: Chronic Versus Acute Administration to Protect Heart, Brain, and Spinal Cord . Annual Review of Nutrition vol. 40 , ( 1 ) 161 - 187 .

Vrettos EI, Valverde IE, Mascarin A, Pallier PN, Cerofolini L, Fragai M, Parigi G, Hirmiz B et al. ( 2020 ) . Cover Feature: Single Peptide Backbone Surrogate Mutations to Regulate Angiotensin GPCR Subtype Selectivity (Chem. Eur. J. 47/2020) . Chemistry - A European Journal vol. 26 , ( 47 ) 10646 - 10646 .

Vrettos EI, Valverde IE, Mascarin A, Pallier PN, Cerofolini L, Fragai M, Parigi G, Hirmiz B et al. ( 2020 ) . Single peptide backbone surrogate mutations to regulate angiotensin GPCR subtype selectivity . Chemistry: A European Journal Article chem.202000924 ,

Yip PK, Schmitzberger M, Al-Hasan M, George J, Tripoliti E, Michael-Titus AT, Clayton D, Priestley JV ( 2020 ) . Serotonin expression in the song circuitry of adult male zebra finches . Neuroscience

Lilley E, Andrews MR, Bradbury EJ, Elliott H, Hawkins P, Ichiyama RM, Keeley J, Michael-Titus AT et al. ( 2020 ) . Refining rodent models of spinal cord injury . Experimental Neurology vol. 328 ,

Thau-Zuchman O, Ingram R, Harvey GG, Cooke T, Palmas F, Pallier PN, Brook J, Priestley JV et al. ( 2019 ) . A Single Injection of Docosahexaenoic Acid Induces a Pro-Resolving Lipid Mediator Profile in the Injured Tissue and a Long-Lasting Reduction in Neurological Deficit after Traumatic Brain Injury in Mice . Journal of Neurotrauma vol. 37 , ( 1 ) 66 - 79 .

Yip PK, Chapman GE, Sillito RR, Ip THR, Akhigbe G, Becker SC, Price AW, Michael-Titus AT et al. ( 2019 ) . Studies on long term behavioural changes in group-housed rat models of brain and spinal cord injury using an automated home cage recording system . Journal of Neuroscience Methods vol. 321 , 49 - 63 .

Yip PK, Bowes AL, Hall JCE, Burguillos MA, Ip THR, Baskerville T, Liu Z-H, Mohamed MAEK et al. ( 2019 ) . Docosahexaenoic acid reduces microglia phagocytic activity via miR-124 and induces neuroprotection in rodent models of spinal cord contusion injury . Human Molecular Genetics vol. 28 , ( 14 ) 2427 - 2448 .

Zuchman OT, Svendsen L, Groenendijk M, de Wilde MC, Tremoleda JL, Michael-Titus AT ( 2019 ) . A NEW KETOGENIC FORMULATION IMPROVES FUNCTIONAL OUTCOME AND REDUCES TISSUE DAMAGE FOLLOWING TRAUMATIC BRAIN INJURY . JOURNAL OF NEUROTRAUMA . vol. 36 , A131 - A132 .

THAU ZUCHMAN O, Gomes RN, DYALL SC, Davies M, PRIESTLEY JV, Groenendijk M, De Wilde MC, LOPEZ TREMOLEDA J et al. ( 2018 ) . Brain phospholipid precursors administered post-injury reduce tissue damage and improve neurological outcome in experimental traumatic brain injury . Journal of Neurotrauma vol. 36 , ( 1 ) 25 - 42 .

Adolph M, Calder PC, Deutz NE, Carmona TG, Klek S, Lev S, Mayer K, Michael-Titus AT et al. ( 2018 ) . Commentary on "Fish Oil-Containing Lipid Emulsions in Adult Parenteral Nutrition: A Review of the Evidence" (https://doi.org/10.1177/0148607117721907) . JPEN J Parenter Enteral Nutr

Shah DK, Ponnusamy V, Evanson J, Kapellou O, Ekitzidou G, Gupta N, Clarke P, Michael-Titus AT et al. ( 2018 ) . Raised Plasma Neurofilament Light Protein Levels Are Associated with Abnormal MRI Outcomes in Newborns Undergoing Therapeutic Hypothermia . Frontiers in Neurology vol. 9 ,

Alvarez K, Lopez-Tremoleda J, Donnan R, Michael-Titus AT, Tomlins PH ( 2018 ) . Heart rate sensitive optical coherence angiography . Conference: Dynamics and Fluctuations in Biomedical Photonics XV vol. 10493 ,

Lopez-Tremoleda J, Alvarez K, ADEN A, DONNAN RS, MICHAEL-TITUS AT, TOMLINS PH ( 2017 ) . Heart-rate sensitive optical coherence angiography for measuring vascular changes due to posttraumatic brain injury in mice . Journal of Biomedical Optics vol. 22 , ( 12 ) 121710 - 121710 .

Calder PC, Adolph M, Deutz NE, Grau T, Innes JK, Klek S, Lev S, Mayer K et al. ( 2017 ) . Lipids in the intensive care unit: Recommendations from the ESPEN Expert Group . Clinical Nutrition vol. 37 , ( 1 ) 1 - 18 .

Venero JL, Yip PK, Carrillo-Jimenez A, King P, Vilalta A, Nomura K, Chau CC, Tr AMSEZ-HLAJSJL et al. ( 2017 ) . Galectin-3 acts as an early alarmin orchestrating brain immune response and promoting neurodegeneration after traumatic brain injury . GLIA . Conference: XIII European Glial Meeting vol. 65 , E504 - E504 .

Lee WLA, Michael-Titus AT, Shah DK ( 2017 ) . Hypoxic-Ischaemic Encephalopathy and the Blood-Brain Barrier in Neonates . Developmental Neuroscience vol. 39 , ( 1-4 ) 49 - 58 .

Yip PK, Carrillo-Jimenez A, King P, Vilalta A, Nomura K, Chau CC, Egerton AMS, Liu Z-H et al. ( 2017 ) . Galectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegeneration . Scientific Reports vol. 7 , Article 41689 , 41689 - 41689 .

Liu Z-H, Yip PK, Priestley JV, Michael-Titus AT ( 2017 ) . A Single Dose of Docosahexaenoic Acid Increases the Functional Recovery Promoted by Rehabilitation after Cervical Spinal Cord Injury in the Rat . J Neurotrauma vol. 34 , ( 9 ) 1766 - 1777 .

Tremoleda JL, Thau-Zuchman O, Davies M, Foster J, Khan I, Vadivelu KC, Yip PK, Sosabowski J et al. ( 2016 ) . In vivo PET imaging of the neuroinflammatory response in rat spinal cord injury using the TSPO tracer [18F]GE-180 and effect of docosahexaenoic acid . European Journal of Nuclear Medicine and Molecular Imaging

Thau-Zuchman O, Pallier PN, Davies M, Groenendijk M, de Wilde MC, Tremoleda JL, Michael-Titus AT ( 2016 ) . A specific multi-nutrient intervention, designed to enhance synapse formation and function, improves functional outcome following traumatic brain injury . BRAIN INJURY vol. 30 , ( 5-6 ) 679 - 679 .

Ponnusamy V, Kapellou O, Yip E, Evanson J, Wong L-F, Michael-Titus A, Yip PK, Shah DK ( 2015 ) . A study of microRNAs from dried blood spots in newborns after perinatal asphyxia: a simple and feasible biosampling method . Pediatric Research vol. 79 , ( 5 ) 799 - 805 .

Tremoleda JL, Thau-Zuchman O, Davies M, Foster J, Khan I, Trigg W, Sosabowski J, Mather SJ et al. ( 2015 ) . T-14: IN VIVO IMAGING OF NEUROINFLAMMATION IN NEUROTRAUMA PRECLINICAL MODELS: POTENTIAL FOR CLINICAL TRANSLATION . Shock vol. 44 Suppl 2 , 24 - 25 .

Pallier PN, Poddighe L, Zbarsky V, Kostusiak M, Choudhury R, Hart T, Burguillos MA, Musbahi O et al. ( 2015 ) . A nutrient combination designed to enhance synapse formation and function improves outcome in experimental spinal cord injury . Neurobiology of Disease vol. 82 , 504 - 515 .

Liu Z-H, Yip PK, Adams L, Davies M, Lee JW, Michael GJ, Priestley JV, Michael-Titus AT ( 2015 ) . A Single Bolus of Docosahexaenoic Acid Promotes Neuroplastic Changes in the Innervation of Spinal Cord Interneurons and Motor Neurons and Improves Functional Recovery after Spinal Cord Injury . Journal of Neuroscience vol. 35 , ( 37 ) 12733 - 12752 .

Tremoleda JL, Thau-Zuchman O, Davies M, Foster J, Khan I, Trigg W, Sosabowski J, Mather SJ et al. ( 2015 ) . <i>IN VIVO</i> IMAGING OF NEUROINFLAMMATION IN NEUROTRAUMA PRECLINICAL MODELS: POTENTIAL FOR CLINICAL TRANSLATION . SHOCK . vol. 44 , 24 - 25 .

Ward RE, Huang W, Kostusiak M, Pallier PN, Michael-Titus AT, Priestley JV ( 2014 ) . A characterization of white matter pathology following spinal cord compression injury in the rat . Neuroscience vol. 260 , 227 - 239 .

Paterniti I, Impellizzeri D, Di Paola R, Esposito E, Gladman S, Yip P, Priestley JV, Michael-Titus AT et al. ( 2014 ) . Docosahexaenoic acid attenuates the early inflammatory response following spinal cord injury in mice: in-vivo and in-vitro studies . J Neuroinflammation vol. 11 ,

Michael-Titus AT, Priestley JV ( 2014 ) . Omega-3 fatty acids and traumatic neurological injury: from neuroprotection to neuroplasticity? . Trends Neurosci vol. 37 , ( 1 ) 30 - 38 .

Michael-Titus A, Revest P, Shortland P ( 2014 ) . The Nervous System: Systems of the Body Series, SECOND EDITION .

Nikolakopoulou Z, Nteliopoulos G, Michael-Titus AT, Parkinson EK ( 2013 ) . Omega-3 polyunsaturated fatty acids selectively inhibit growth in neoplastic oral keratinocytes by differentially activating ERK1/2 . Carcinogenesis vol. 34 , ( 12 ) 2716 - 2725 .

Nikolakopoulou Z, Shaikh MH, Dehlawi H, Michael-Titus AT, Parkinson EK ( 2013 ) . The induction of apoptosis in pre-malignant keratinocytes by omega-3 polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) is inhibited by albumin . Toxicol Lett vol. 218 , ( 2 ) 150 - 158 .

Lim S-N, Gladman SJ, Dyall SC, Patel U, Virani N, Kang JX, Priestley JV, Michael-Titus AT ( 2013 ) . Transgenic mice with high endogenous omega-3 fatty acids are protected from spinal cord injury . Neurobiol Dis vol. 51 , 104 - 112 .

Perera AP, Kotarba K, Kenny F, Connelly J, Michael-Titus A, Wheeler A ( 2013 ) . Characterising the effect of substrate stiffness on macrophage behaviour . MOLECULAR BIOLOGY OF THE CELL . vol. 24 ,

Lim S-N, Huang W, Hall JCE, Michael-Titus AT, Priestley JV ( 2013 ) . Improved outcome after spinal cord compression injury in mice treated with docosahexaenoic acid . Exp Neurol vol. 239 , 13 - 27 .

Yip PK, Pizzasegola C, Gladman S, Biggio ML, Marino M, Jayasinghe M, Ullah F, Dyall SC et al. ( 2013 ) . The omega-3 fatty acid eicosapentaenoic acid accelerates disease progression in a model of amyotrophic lateral sclerosis . PLoS One vol. 8 , ( 4 )

Michael‐Titus A, Whelpton R, Yaqub Z ( 2012 ) . Binding of temoporfin to the lipoprotein fractions of human serum . British Journal of Clinical Pharmacology vol. 40 , ( 6 ) 594 - 597 .

Hall JCE, Priestley JV, Perry VH, Michael-Titus AT ( 2012 ) . Docosahexaenoic acid, but not eicosapentaenoic acid, reduces the early inflammatory response following compression spinal cord injury in the rat . J Neurochem vol. 121 , ( 5 ) 738 - 750 .

Gladman SJ, Huang W, Lim S-N, Dyall SC, Boddy S, Kang JX, Knight MM, Priestley JV et al. ( 2012 ) . Improved outcome after peripheral nerve injury in mice with increased levels of endogenous ω-3 polyunsaturated fatty acids . J Neurosci vol. 32 , ( 2 ) 563 - 571 .

Priestley JV, Michael-Titus AT, Tetzlaff W ( 2012 ) . Limiting spinal cord injury by pharmacological intervention . Handb Clin Neurol vol. 109 , 463 - 484 .

Gladman S, Lim S-N, Dyall S, Knight MM, Priestley JV, Michael-Titus AT ( 2011 ) . Omega-3 fatty acids and acute neurological trauma: a perspective on clinical translation* . Oléagineux Corps gras Lipides vol. 18 , ( 6 ) 317 - 323 .

Zbarsky-Barquero⁎ V, Sijben J, De Wilde M, Priestley JV, Michael-Titus AT ( 2011 ) . A multi-nutrient composition with neuroprotective properties in spinal cord injury . European Journal of Pharmacology vol. 668 , e10 - e11 .

Wann AKT, Mistry J, Blain EJ, Michael-Titus A, Knight MM ( 2011 ) . Eicosapenaenoic acid (EPA) and docasahexaenoic acid (DHA) reduce IL-1 beta mediated cartilage degradation . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 92 , A11 - A12 .

Gladman SJ, Ward RE, Michael-Titus AT, Knight MM, Priestley JV ( 2010 ) . The effect of mechanical strain or hypoxia on cell death in subpopulations of rat dorsal root ganglion neurons in vitro . Neuroscience vol. 171 , ( 2 ) 577 - 587 .

Jokic N, Yip PK, Michael-Titus A, Priestley JV, Malaspina A ( 2010 ) . The human G93A-SOD1 mutation in a pre-symptomatic rat model of amyotrophic lateral sclerosis increases the vulnerability to a mild spinal cord compression . BMC Genomics vol. 11 , 633 - 633 .

Ward RE, Huang W, Curran OE, Priestley JV, Michael-Titus AT ( 2010 ) . Docosahexaenoic acid prevents white matter damage after spinal cord injury . J Neurotrauma vol. 27 , ( 10 ) 1769 - 1780 .

Malaspina A, Ngoh SFA, Ward RE, Hall JCE, Tai FWD, Yip PK, Jones C, Jokic N et al. ( 2010 ) . Activation transcription factor-3 activation and the development of spinal cord degeneration in a rat model of amyotrophic lateral sclerosis . Neuroscience vol. 169 , ( 2 ) 812 - 827 .

Dyall SC, Michael GJ, Michael-Titus AT ( 2010 ) . Omega-3 fatty acids reverse age-related decreases in nuclear receptors and increase neurogenesis in old rats . J Neurosci Res vol. 88 , ( 10 ) 2091 - 2102 .

Robson LG, Dyall SC, Sidloff D, Michael-Titus AT ( 2010 ) . Omega-3 polyunsaturated fatty acids increase the neurite outgrowth of rat sensory neurones throughout development and in aged animals . Neurobiol Aging vol. 31 , ( 4 ) 678 - 687 .

Kiasalari Z, Salehi I, Zhong Y, McMahon SB, Michael-Titus AT, Michael GJ ( 2010 ) . Identification of Perineal Sensory Neurons Activated by Innocuous Heat . J COMP NEUROL vol. 518 , ( 2 ) 137 - 162 .

Michael-Titus A, Revest P, Shortland P ( 2010 ) . 1 ORGANIZATION OF THE NERVOUS SYSTEM . The Nervous System , Elsevier

Michael-Titus A, Revest P, Shortland P ( 2010 ) . 10 MOTOR SYSTEMS II THE BASAL GANGLIA . The Nervous System , Elsevier

Michael-Titus A, Revest P, Shortland P ( 2010 ) . 11 STROKE AND HEAD INJURY . The Nervous System , Elsevier

Michael-Titus A, Revest P, Shortland P ( 2010 ) . 12 INFECTION IN THE CENTRAL NERVOUS SYSTEM . The Nervous System , Elsevier

Michael-Titus A, Revest P, Shortland P ( 2010 ) . 13 EPILEPSY . The Nervous System , Elsevier

Michael-Titus A, Revest P, Shortland P ( 2010 ) . 14 DEMENTIA . The Nervous System , Elsevier

Michael-Titus A, Revest P, Shortland P ( 2010 ) . 15 SCHIZOPHRENIA . The Nervous System , Elsevier

Michael-Titus A, Revest P, Shortland P ( 2010 ) . 16 DEPRESSION AND ANXIETY . The Nervous System , Elsevier

Michael-Titus A, Revest P, Shortland P ( 2010 ) . 17 ADDICTION . The Nervous System , Elsevier

Michael-Titus A, Revest P, Shortland P ( 2010 ) . 2 ELEMENTS OF CELLULAR AND MOLECULAR NEUROSCIENCE . The Nervous System , Elsevier

Michael-Titus A, Revest P, Shortland P ( 2010 ) . 3 CLINICAL EXAMINATION . The Nervous System , Elsevier

Michael-Titus A, Revest P, Shortland P ( 2010 ) . 4 THE SPINAL CORD . The Nervous System , Elsevier

Michael-Titus A, Revest P, Shortland P ( 2010 ) . 5 PAIN AND ANALGESIA . The Nervous System , Elsevier

Michael-Titus A, Revest P, Shortland P ( 2010 ) . 6 CRANIAL NERVES AND THE BRAINSTEM . The Nervous System , Elsevier

Michael-Titus A, Revest P, Shortland P ( 2010 ) . 7 THE VISUAL SYSTEM . The Nervous System , Elsevier

Michael-Titus A, Revest P, Shortland P ( 2010 ) . 8 HEARING AND BALANCE THE AUDITORY AND VESTIBULAR SYSTEMS . The Nervous System , Elsevier

Michael-Titus A, Revest P, Shortland P ( 2010 ) . 9 MOTOR SYSTEMS I DESCENDING PATHWAYS AND CEREBELLUM . The Nervous System , Elsevier

Wann AK, Mistry J, Michael-Titus A, Knight MM ( 2010 ) . Eicosapenaenoic acid (EPA) and docasahexaenoic acid (DHA) reduce IL-1β mediated cartilage degradation . European Cells and Materials . vol. 20 ,

Wann AKT, Mistry J, Blain EJ, Michael-Titus AT, Knight MM ( 2010 ) . Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1β-mediated cartilage degradation . Arthritis Res Ther vol. 12 , ( 6 )

Michael-Titus A, Revest P, Shortland P ( 2010 ) . The Nervous System: Systems of the Body Series .

Lim S-N, Huang W, Hall JCE, Ward RE, Priestley JV, Michael-Titus AT ( 2010 ) . The acute administration of eicosapentaenoic acid is neuroprotective after spinal cord compression injury in rats . Prostaglandins Leukot Essent Fatty Acids vol. 83 , ( 4-6 ) 193 - 201 .

Nikolakopoulou Z, Michael-Titus AT, Parkinson EK ( 2009 ) . Abstract B152: The selective effect of omega-3 polyunsaturated fatty acids on normal and neoplastic oral keratinocyte apoptosis . Molecular Cancer Therapeutics . vol. 8 , b152 - b152 .

Huang WL, Bhavsar A, Ward RE, Hall JCE, Priestley JV, Michael-Titus AT ( 2009 ) . Arachidonyl Trifluoromethyl Ketone Is Neuroprotective after Spinal Cord Injury . J NEUROTRAUM vol. 26 , ( 8 ) 1429 - 1434 .

Huang W, Bhavsar A, Ward RE, Hall JCE, Priestley JV, Michael-Titus AT ( 2009 ) . Arachidonyl trifluoromethyl ketone is neuroprotective after spinal cord injury . J Neurotrauma vol. 26 , ( 8 ) 1429 - 1434 .

Hall JCE, Priestley JV, Perry VH, Michael-Titus A ( 2009 ) . WINTR VISA AWARD WINNER DOES ACUTE TREATMENT WITH DOCOSAHEXAENOIC OR EICOSAPENTAENOIC ACID AFFECT INFLAMMATORY MARKERS FOLLOWING COMPRESSION SPINAL CORD INJURY? . JOURNAL OF NEUROTRAUMA . vol. 26 , A45 - A45 .

Michael-Titus AT ( 2009 ) . Omega-3 fatty acids: their neuroprotective and regenerative potential in traumatic neurological injury . CLIN LIPIDOL vol. 4 , ( 3 ) 343 - 353 .

Michael-Titus AT, Albert M, Michael GJ, Michaelis T, Watanabe T, Frahm J, Pudovkina O, van der Hart MGC et al. ( 2008 ) . SONU20176289, a compound combining partial dopamine D(2) receptor agonism with specific serotonin reuptake inhibitor activity, affects neuroplasticity in an animal model for depression . Eur J Pharmacol vol. 598 , ( 1-3 ) 43 - 50 .

Hall JCE, Michael-Titus A, Perry VH, Priestley JV ( 2008 ) . The inflammatory response and locomotor recovery following a spinal compression injury . JOURNAL OF NEUROIMMUNOLOGY . vol. 197 , 172 - 172 .

Malaspina A, Michael-Titus AT ( 2008 ) . Is the modulation of retinoid and retinoid-associated signaling a future therapeutic strategy in neurological trauma and neurodegeneration? . J NEUROCHEM vol. 104 , ( 3 ) 584 - 595 .

Whelpton R, Michael‐Titus AT, Jamdar RP, Abdillahi K, Grahn MF ( 2008 ) . Distribution and Excretion of Radiolabeled Temoporfin in a Murine Tumor Model . Photochemistry and Photobiology vol. 63 , ( 6 ) 885 - 891 .

Whelpton R, Michael‐Titus AT, Basra SS, Grahn M ( 2008 ) . DISTRIBUTION OF TEMOPORFIN, A NEW PHOTOSENSITIZER FOR THE PHOTODYNAMIC THERAPY OF CANCER, IN A MURINE TUMOR MODEL . Photochemistry and Photobiology vol. 61 , ( 4 ) 397 - 401 .

Dyall SC, Michael-Titus AT ( 2008 ) . Neurological Benefits of Omega-3 Fatty Acids . NEUROMOL MED vol. 10 , ( 4 ) 219 - 235 .

Jokic N, Ling YY, Ward RE, Michael-Titus AT, Priestley JV, Malaspina A ( 2007 ) . Retinoid receptors in chronic degeneration of the spinal cord: observations in a rat model of amyotrophic lateral sclerosis . J Neurochem vol. 103 , ( 5 ) 1821 - 1833 .

Huang WL, King VR, Curran OE, Dyall SC, Ward RE, Lal N, Priestley JV, Michael-Titus AT ( 2007 ) . A combination of intravenous and dietary docosahexaenoic acid significantly improves outcome after spinal cord injury . Brain vol. 130 , ( Pt 11 ) 3004 - 3019 .

King VR, Averill SA, Hewazy D, Priestley JV, Torup L, Michael-Titus AT ( 2007 ) . Erythropoietin and carbamylated erythropoietin are neuroprotective following spinal cord hemisection in the rat . Eur J Neurosci vol. 26 , ( 1 ) 90 - 100 .

Makwana M, Dyall S, Raivich G, Michael-Titus A ( 2007 ) . Effect of docosahexaenoic acid in a mouse facial nerve injury model . Oléagineux Corps gras Lipides vol. 14 , ( 3-4 ) 233 - 233 .

Ward RE, Huang W, Hall JCE, Priestley JV, Michael-Titus AT ( 2007 ) . Effect of docosahexaenoic acid on axonal damage after spinal cord injury* . Oléagineux Corps gras Lipides vol. 14 , ( 3-4 ) 234 - 234 .

Dyall SC, Michael GJ, Michael-Titus AT ( 2007 ) . Omega-3 polyunsaturated fatty acids reverse age-related decreases in retinoic acid receptors, retinoid x receptors and peroxisome-proliferator-activated receptors in rat forebrain . Oléagineux Corps gras Lipides vol. 14 , ( 3-4 ) 232 - 232 .

Dyall SC, Michael GJ, Whelpton R, Scott AG, Michael-Titus AT ( 2007 ) . Dietary enrichment with omega-3 polyunsaturated fatty acids reverses age-related decreases in the GluR2 and NR2B glutamate receptor subunits in rat forebrain . Neurobiol Aging vol. 28 , ( 3 ) 424 - 439 .

Michael-Titus AT ( 2007 ) . Omega-3 fatty acids and neurological injury . Prostaglandins Leukot Essent Fatty Acids vol. 77 , ( 5-6 ) 295 - 300 .

Dourmap N, Michael‐Titus A, Costentin J ( 2006 ) . Differential Effect of Intrastriatal Kainic Acid on the Modulation of Dopamine Release by μ‐ and δ‐Opioid Peptides: A Microdialysis Study . Journal of Neurochemistry vol. 58 , ( 2 ) 709 - 713 .

King VR, Huang WL, Dyall SC, Curran OE, Priestley JV, Michael-Titus AT ( 2006 ) . Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat . J Neurosci vol. 26 , ( 17 ) 4672 - 4680 .

Dourmap N, Michael‐Titus A, Costentin J ( 2006 ) . Acetorphan, an Enkephalinase Inhibitor, Modulates Dopaminergic Transmission in Rat Olfactory Tubercle, but not in the Nucleus Accumbens and Striatum . European Journal of Neuroscience vol. 2 , ( 9 ) 783 - 787 .

Penschuck S, Flagstad P, Didriksen M, Leist M, Michael-Titus AT ( 2006 ) . Decrease in parvalbumin-expressing neurons in the hippocampus and increased phencyclidine-induced locomotor activity in the rat methylazoxymethanol (MAM) model of schizophrenia . EUR J NEUROSCI vol. 23 , ( 1 ) 279 - 284 .

Flagstad P, Mørk A, Glenthøj BY, van Beek J, Michael-Titus AT, Didriksen M ( 2004 ) . Disruption of neurogenesis on gestational day 17 in the rat causes behavioral changes relevant to positive and negative schizophrenia symptoms and alters amphetamine-induced dopamine release in nucleus accumbens . Neuropsychopharmacology vol. 29 , ( 11 ) 2052 - 2064 .

Nazir S, Michael GJ, Michael-Titus AT ( 2002 ) . Distribution of NMDA and AMPA glutamate receptor subunits in rat prefrontal cortex and the effect of chronic imipramine treatment on the GluR2 subunit . BRIT J PHARMACOL vol. 135 ,

Hawkins A, McCune L, Whelpton R, Michael-Titus AT ( 2002 ) . Effect of noradrenaline and 5-HT on excitatory amino acid release in rat prefrontal cortex . BRIT J PHARMACOL vol. 135 ,

Whelpton R, Michael-Titus AT, Fox A ( 2002 ) . Bioanalysis of temoporfin, a new pharmacodynamic therapy agent . CHROMATOGRAPHIA . vol. 55 , S177 - S181 .

Michael-Titus AT, Fernandes K, Setty H, Whelpton R ( 2002 ) . In vivo metabolism and clearance of substance P and co-expressed tachykinins in rat striatum . Neuroscience vol. 110 , ( 2 ) 277 - 286 .

Toner CC, Connell K, Whelpton R, Bains S, Michael-Titus AT, McLaughlin DP, Stamford JA ( 2001 ) . Effects of sevoflurane on dopamine, glutamate and aspartate release in an in vitro model of cerebral ischaemia . BRIT J ANAESTH vol. 86 , ( 4 ) 550 - 554 .

Khan S, Whelpton R, Michael-Titus AT ( 2000 ) . Substance P modulation of striatal dopamine outflow is determined by M1 and M2 muscarinic receptors in male Wistar rats . Neuroscience Letters vol. 293 , ( 3 ) 179 - 182 .

Michael-Titus AT, Bains S, Jeetle J, Whelpton R ( 2000 ) . Imipramine and phenelzine decrease glutamate overflow in the prefrontal cortex—a possible mechanism of neuroprotection in major depression? . Neuroscience vol. 100 , ( 4 ) 681 - 684 .

Michael-Titus AT, Blackburn D, Connolly Y, Priestley JV, Whelpton R ( 1999 ) . N- and C-terminal substance P fragments . Neuroreport vol. 10 , ( 10 ) 2209 - 2213 .

Khan S, Sandhu J, Whelpton R, Michael-Titus AT ( 1998 ) . Substance P fragments and striatal endogenous dopamine outflow: interaction with substance P . Neuropeptides vol. 32 , ( 6 ) 519 - 526 .

Whelpton R, Michael-Titus AT, Stephens SM, Yau KW, Fengas D ( 1998 ) . Identification of substance P metabolites using a combination of reversed-phase high-performance liquid chromatography and capillary electrophoresis . Journal of Chromatography B vol. 716 , ( 1-2 ) 95 - 106 .

MichaelTitus AT, Whelpton R, Stephens SM, Yau KW ( 1997 ) . Metabolism of substance P in rat striatum studies using a combination of high performance liquid chromatography (HPLC) and capillary electrophoresis (CE) . BRIT J PHARMACOL vol. 122 , P79 - P79 .

Khan S, Sandhu J, Whelpton R, MichaelTitus AT ( 1996 ) . Substance fragments, SP1-9 and SP6-11, modulate endogenous dopamine outflow in rat striatum . BRIT J PHARMACOL vol. 119 , P175 - P175 .

Khan S, Grogan E, Whelpton R, Michael-Titus AT ( 1996 ) . N- and C-terminal substance P fragments modulate striatal dopamine outflow through a cholinergic link mediated by muscarinic receptors . Neuroscience vol. 73 , ( 4 ) 919 - 927 .

Khan S, Whelpton R, Michael-Titus AT ( 1996 ) . Evidence for modulatory effects of substance P fragments (1–4) and (8–11) on endogenous dopamine outflow in rat striatal slices . Neuroscience Letters vol. 205 , ( 1 ) 33 - 36 .

KHAN S, GROGAN E, WHELPTON R, MICHAELTITUS AT ( 1995 ) . SUBSTANCE-P AND ITS FRAGMENT-(1-7) AND FRAGMENT-(5-11) MODULATE STRIATAL DOPAMINE OUTFLOW VIA A CHOLINERGIC LINK MEDIATED BY MUSCARINIC RECEPTORS . BRIT J PHARMACOL vol. 116 , P96 - P96 .

Khan S, Brooks N, Whelpton R, Michael-Titus AT ( 1995 ) . Substance P-(1–7) and substance P-(5–11) locally modulate dopamine release in rat striatum . European Journal of Pharmacology vol. 282 , ( 1-3 ) 229 - 233 .

KHAN S, WHELPTON R, MICHAEL-TITUS A ( 1995 ) . ENDOGENOUS DOPAMINE OUTFLOW FROM RAT STRIATAL SLICES IN STATIC AND DYNAMIC CONDITIONS . NEUROSCI RES COMMUN vol. 16 , ( 3 ) 145 - 153 .

IRAVANI MM, KHAN S, MICHAELTITUS A, WHELPTON R, KRUK ZL ( 1995 ) . EFFECTS OF 6-HYDROXYDOPAMINE LESIONS IN THE VENTRAL TEGMENTAL AREA OR SUBSTANTIA-NIGRA ON DOPAMINE RELEASE IN SUBREGIONS OF THE RAT STRIATUM . BRIT J PHARMACOL vol. 114 , P337 - P337 .

WHELPTON R, MICHAELTITUS AT, YAQUB Z ( 1995 ) . TEMOPORFIN BINDING TO HUMAN SERUM-LIPOPROTEINS . BRIT J PHARMACOL vol. 114 , P265 - P265 .

Das D, Rogers J, Michael-Titus AT ( 1994 ) . Comparative study of the effects of mu, delta and kappa opioid agonists on 3H-dopamine uptake in rat striatum and nucleus accumbens . Neuropharmacology vol. 33 , ( 2 ) 221 - 226 .

Bousselmame R, Michael-Titus A, Costentin J ( 1991 ) . Desensitization of μ-opioid receptors does not modify the analgesia induced by an enkephalinase inhibitor . European Journal of Pharmacology vol. 203 , ( 2 ) 295 - 297 .

Bousselmame R, Eustache M, Michael-Titus A, Costentin J ( 1991 ) . Chronic inhibition of enkephalinase induces changes in the antinociceptive and locomotor effects of the enkephalinase inhibitor acetorphan in rats . Neuropharmacology vol. 30 , ( 8 ) 865 - 870 .

Michael-Titus A, Bousselmame R, Costentin J ( 1990 ) . Stimulation of dopamine D2 receptors induces an analgesia involving an opiodergic but non enkephalinergic link . European Journal of Pharmacology vol. 187 , ( 2 ) 201 - 207 .

Dourmap N, Michael-Titus A, Costentin J ( 1990 ) . Local enkephalins tonically modulate dopamine release in the striatum: a microdialysi study . Brain Research vol. 524 , ( 1 ) 153 - 155 .

Michael-Titus A, Dourmap N, Costentin J, Schwartz JC ( 1990 ) . Role of delta opioid receptors in the effects of inhibitors of enkephalin-degrading peptidases on the horizontal and vertical components of locomotion in mice . Neuropeptides vol. 15 , ( 2 ) 89 - 100 .

Costentin J, Duterte-Boucher D, Panissaud C, Michael-Titus A ( 1990 ) . Dopamine D1 and D2 receptors mediate opposite effects of apomorphine on the body temperature of reserpinized mice . Neuropharmacology vol. 29 , ( 1 ) 31 - 35 .

Michael-Titus A, Dourmap N, Costentin J ( 1989 ) . MU and delta opioid receptors control differently the horizontal and vertical components of locomotor activity in mice . Neuropeptides vol. 13 , ( 4 ) 235 - 242 .

Duterte-Eoucher D, Panissaud C, Michael-Titus A, Costentin J ( 1989 ) . Stimulation of central D1 dopamine receptors reverses reserpine-induced hypothermia in mice . Neuropharmacology vol. 28 , ( 4 ) 419 - 421 .

Michael-Titus A, Dourmap N, Caline H, Costentin J, Schwartz J-C ( 1989 ) . Role of endogenous enkephalins in locomotion and nociception studied with peptidase inhibitors in two inbred strains of mice (C57BL/6J AND DBA/2J) . Neuropharmacology vol. 28 , ( 2 ) 117 - 122 .

Michael-Titus A, Costentin J ( 1987 ) . Analgesic effects of metapramine and evidence against the involvement of endogenous enkephalins in the analgesia induced by tricyclic antidepressants . Pain vol. 31 , ( 3 ) 391 - 400 .

Michael-Titus A, Preterre P, Giros B, Costentin J ( 1987 ) . Role of endogenous enkephalins in locomotion evidenced by acetorphan, an "enkephalinase" inhibitor . Journal of Pharmacology and Experimental Therapeutics vol. 243 , ( 3 ) 1062 - 1066 .