Publications: Prof Yaohe Wang

Lian X, Zhao X, Zhong J, Zhang C, Chu Y, Wang Y, Lu S, Wang Z ( 2023 ) . A New HEK293 Cell with CR2 Region of E1A Gene Deletion Prevents the Emergence of Replication-Competent Adenovirus . Cancers vol. 15 , ( 24 )

Li S, Guo Y, Ning W, Chen Y, Xu J, Zhao C, Wang J, Qu Y et al. ( 2023 ) . Oncolytic virus Ad-TD-nsIL-12 inhibits glioma growth and reprograms the tumor immune microenvironment . Life Sciences vol. 336 ,

Baleeiro RB, Liu P, Dunmall LSC, Di Gioia C, Nagano A, Cutmore L, Wang J, Chelala C et al. ( 2023 ) . Personalized neoantigen viro-immunotherapy platform for triple-negative breast cancer . Journal for ImmunoTherapy of Cancer vol. 11 , ( 8 )

Wang L, Wang X, Wu Y, Wang J, Zhou W, Wang J, Guo H, Zhang N et al. ( 2023 ) . A novel microenvironment regulated system CAR-T (MRS.CAR-T) for immunotherapeutic treatment of esophageal squamous carcinoma . Cancer Letters vol. 568 ,

Jia Y, Wang Y, Dunmall LSC, Lemoine NR, Wang P, Wang Y ( 2023 ) . Syrian hamster as an ideal animal model for evaluation of cancer immunotherapy . Frontiers in Immunology vol. 14 ,

Wang L, Wu Y, Wang X, Wang J, Zhou W, Wang J, Guo H, Wu Y et al. ( 2023 ) . A Novel Microenvironment Regulated System CAR-T (MRS.CAR-T) for Immunotherapeutic Treatment of Esophageal Squamous Carcinoma . MOLECULAR THERAPY . vol. 31 , 645 - 646 .

Wong HH, Jiang G, Gangeswaran R, Wang P, Wang J, Yuan M, Wang H, Bhakta V et al. ( 2022 ) . Modification of the Early Gene Enhancer-promoter Improves the Oncolytic Potency of Adenovirus 11 . Molecular Therapy vol. 31 , ( 1 )

Miao J, Lan T, Guo H, Wang J, Zhang G, Wang Z, Yang P, Li H et al. ( 2022 ) . Characterization of SHARPIN knockout Syrian hamsters developed using CRISPR/Cas9 system . Animal Models and Experimental Medicine vol. 6 , ( 5 ) 489 - 498 .

Zhang N, Wu Y, Wu Y, Wang L, Chen J, Wang X, Dunmall LSC, Cheng Z et al. ( 2022 ) . Ferroptosis-Related Genes Are Potential Therapeutic Targets and the Model of These Genes Influences Overall Survival of NSCLC Patients . Cells vol. 11 , ( 14 )

Lan T, Wang Y, Miao J, Guo H, Wang Z, Wang J, Zhang C, Yang P et al. ( 2022 ) . Deoxythymidylate Kinase as a Promising Marker for Predicting Prognosis and Immune Cell Infiltration of Pan-cancer . Frontiers in Molecular Biosciences vol. 9 ,

Miao J, Xu H, Tian Y, Wang J, Tang W, Wang Y, Miao M, Liu J et al. ( 2022 ) . COVID-19 Resulting in Potential Hearing Damage of Rodents . Chinese medicine and natural products vol. 02 , ( 01 ) e28 - e31 .

Wang Z, Cheng Z, Lu S, Dunmall LSC, Wang J, Guo Y, Wang Y ( 2022 ) . Characterization of the Intra-tumoral B Cell Immunoglobulin Repertoire Is of Prognostic Value for Esophageal Squamous Cell Carcinoma . Frontiers in Immunology vol. 13 ,

Sun Y, Zhang Z, Zhang C, Zhang N, Wang P, Chu Y, Dunmall LSC, Lemoine NR et al. ( 2022 ) . An effective therapeutic regime for treatment of glioma using oncolytic vaccinia virus expressing IL-21 in combination with immune checkpoint inhibition . Molecular Therapy — Oncolytics vol. 26 , 105 - 119 .

Wang L, Dunmall LSC, Cheng Z, Wang Y ( 2022 ) . Remodeling the tumor microenvironment by oncolytic viruses: beyond oncolysis of tumor cells for cancer treatment . Journal for ImmunoTherapy of Cancer vol. 10 , ( 5 )

Xu L, Wang J, Zhang D, Song L, Wu H, Wang J, Miao J, Guo H et al. ( 2022 ) . The two-faced role of ATF2 on cisplatin response in gastric cancer depends on p53 context . Cell & Bioscience vol. 12 , ( 1 )

Baleeiro RB, Bouwens CJ, Liu P, Di Gioia C, Dunmall LSC, Nagano A, Gangeswaran R, Chelala C et al. ( 2022 ) . MHC class II molecules on pancreatic cancer cells indicate a potential for neo-antigen-based immunotherapy . OncoImmunology vol. 11 , ( 1 )

Baleeiro RB, Dunmall LSC, Liu P, Lu S, Lone Y, Lemoine NR, Wang Y ( 2022 ) . Optimized Anchor-Modified Peptides Targeting Mutated RAS Are Promising Candidates for Immunotherapy . Frontiers in Immunology vol. 13 ,

Cao D, Song Q, Li J, Dunmall LSC, Jiang Y, Qin B, Wang J, Guo H et al. ( 2022 ) . Redirecting anti-Vaccinia virus T cell immunity for cancer treatment by AAV-mediated delivery of the VV B8R gene . Molecular Therapy — Oncolytics vol. 25 , 264 - 275 .

Miao J, Li R, Van Wettere AJ, Guo H, Tabaran A-F, O'Sullivan MG, Carlson T, Scott PM et al. ( 2021 ) . Cancer spectrum in TP53-deficient golden Syrian hamsters: A new model for Li-Fraumeni syndrome . Journal of Carcinogenesis vol. 20 , ( 1 )

Lu S, Zhang Z, Du P, Chard LS, Yan W, El Khouri M, Wang Z, Zhang Z et al. ( 2021 ) . Correction: A Virus-infected, Reprogrammed Somatic Cell–derived Tumor Cell (VIReST) Vaccination Regime can Prevent Initiation and Progression of Pancreatic Cancer . Clinical Cancer Research vol. 27 , ( 9 ) 2663 - 2663 .

Lan T, Xue X, Dunmall LC, Miao J, Wang Y ( 2021 ) . Patient-derived xenograft: a developing tool for screening biomarkers and potential therapeutic targets for human esophageal cancers . Aging vol. 13 , ( 8 ) 12273 - 12293 .

Xue X, Shi J, Xu H, Qin Y, Yang Z, Feng S, Liu D, Jian L et al. ( 2021 ) . Dynamics of binding ability prediction between spike protein and human ACE2 reveals the adaptive strategy of SARS-CoV-2 in humans . Scientific Reports vol. 11 , ( 1 )

Marelli G, Dunmall LSC, Yuan M, Di Gioia C, Miao J, Cheng Z, Zhang Z, Liu P et al. ( 2021 ) . A systemically deliverable Vaccinia virus with increased capacity for intertumoral and intratumoral spread effectively treats pancreatic cancer . Journal for ImmunoTherapy of Cancer vol. 9 , ( 1 )

Wang N, Wang J, Zhang Z, Cao H, Yan W, Chu Y, Dunmall LSC, Wang Y ( 2020 ) . A novel vaccinia virus enhances anti-tumor efficacy and promotes a long-term anti-tumor response in a murine model of colorectal cancer . Molecular Therapy — Oncolytics vol. 20 , 71 - 81 .

Zhang Z, Zhang C, Miao J, Wang Z, Wang Z, Cheng Z, Wang P, Dunmall LSC et al. ( 2020 ) . A Tumor-Targeted Replicating Oncolytic Adenovirus Ad-TD-nsIL12 as a Promising Therapeutic Agent for Human Esophageal Squamous Cell Carcinoma . Cells vol. 9 , ( 11 )

Miao J-X, Wang J-Y, Li H-Z, Guo H-R, Dunmall LSC, Zhang Z-X, Cheng Z-G, Gao D-L et al. ( 2020 ) . Promising xenograft animal model recapitulating the features of human pancreatic cancer . World Journal of Gastroenterology vol. 26 , ( 32 ) 4802 - 4816 .

Zhang Z, Lu S, Dunmall LSC, Wang Z, Cheng Z, Zhang Z, Yan W, Chu Y et al. ( 2020 ) . Treatment and Prevention of Lung Cancer Using a Virus-Infected Reprogrammed Somatic Cell-Derived Tumor Cell Vaccination (VIReST) Regime . Frontiers in Immunology vol. 11 ,

( 2020 ) . Correction: A new oncolytic Vaccinia virus augments antitumor immune responses to prevent tumor recurrence and metastasis after surgery . Journal for ImmunoTherapy of Cancer vol. 8 , ( 1 )

Ahmed J, Chard LS, Yuan M, Wang J, Howells A, Li Y, Li H, Zhang Z et al. ( 2020 ) . A new oncolytic Vaccinia virus augments antitumor immune responses to prevent tumor recurrence and metastasis after surgery . Journal for ImmunoTherapy of Cancer vol. 8 , ( 1 )

Ferguson MS, Chard Dunmall LS, Gangeswaran R, Marelli G, Tysome JR, Burns E, Whitehead MA, Aksoy E et al. ( 2020 ) . Transient Inhibition of PI3Kδ Enhances the Therapeutic Effect of Intravenous Delivery of Oncolytic Vaccinia Virus . Molecular Therapy vol. 28 , ( 5 ) 1263 - 1275 .

Cutmore LC, Brown NF, Raj D, Chauduri S, Wang P, Maher J, Wang Y, Lemoine NR et al. ( 2020 ) . Pancreatic Cancer UK Grand Challenge: Developments and challenges for effective CAR T cell therapy for pancreatic ductal adenocarcinoma . Pancreatology

Lu S, Zhang Z, Du P, Chard LS, Yan W, Khouri ME, Wang Z, Zhang Z et al. ( 2020 ) . A Virus-Infected, Reprogrammed Somatic Cell–Derived Tumor Cell (VIReST) Vaccination Regime Can Prevent Initiation and Progression of Pancreatic Cancer . Clinical Cancer Research vol. 26 , ( 2 ) 465 - 476 .

Li R, Ying B, Liu Y, Spencer JF, Miao J, Tollefson AE, Brien JD, Wang Y et al. ( 2020 ) . Generation and characterization of an IL2RG knockout Syrian hamster model for XSCID and HAdV-C6 infection in immunocompromised patients . Disease Models & Mechanisms

Miao J, Chard LS, Wang Z, Wang Y ( 2019 ) . Syrian Hamster as an Animal Model for the Study on Infectious Diseases . Frontiers in Immunology vol. 10 ,

Hallden G, Wang Y, Wong H-H, Lemoine NR ( 2019 ) . ONCOLYTIC ADENOVIRUSES FOR CANCER GENE THERAPY . Advanced Textbook on Gene Transfer, Gene Therapy and Genetic Pharmacology , World Scientific Publishing

Di Gioia C, Yuan M, Wang Y ( 2019 ) . Vaccinia Virus Genome Editing Using CRISPR . vol. 2023 , 109 - 117 .

Butcher K, Kannappan V, Azar K, Kilari R, Nkeonye O, Morris MR, McConville C, Wang Y et al. ( 2018 ) . Abstract 1975: Disulfiram targets hypoxia-induced cancer stem cells and reverses chemoresistance in non-small cell lung cancer . Cancer Research . vol. 78 , 1975 - 1975 .

Miao J, Ying B, Li R, Tollefson AE, Spencer JF, Wold WSM, Song S-H, Kong I-K et al. ( 2018 ) . Characterization of an N-Terminal Non-Core Domain of RAG1 Gene Disrupted Syrian Hamster Model Generated by CRISPR Cas9 . Viruses vol. 10 , ( 5 )

Marelli G, Howells A, Lemoine NR, Wang Y ( 2018 ) . Oncolytic Viral Therapy and the Immune System: A Double-Edged Sword Against Cancer . Frontiers in Immunology vol. 9 , 866 - 866 .

Wang P, Li X, Wang J, Gao D, Li Y, Li H, Chu Y, Zhang Z et al. ( 2018 ) . Author Correction: Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent . Nature Communications vol. 9 , ( 1 )

Li R, Miao J, Fan Z, Song S, Kong I-K, Wang Y, Wang Z ( 2018 ) . Production of Genetically Engineered Golden Syrian Hamsters by Pronuclear Injection of the CRISPR/Cas9 Complex . Journal of Visualized Experiments ( 131 )

Delaunay T, Violland M, Boisgerault N, Dutoit S, Vignard V, Münz C, Gannage M, Dréno B et al. ( 2017 ) . Oncolytic viruses sensitize human tumor cells for NY-ESO-1 tumor antigen recognition by CD4+ effector T cells . Oncoimmunology vol. 7 , ( 3 ) e1407897 - e1407897 .

Wang Z, Wang Y, Wang S, Zhang L-R, Zhang N, Cheng Z, Liu Q, Shields KJ et al. ( 2017 ) . CRISPR-Cas9 HDR system enhances AQP1 gene expression . Oncotarget vol. 5 , ( 0 ) 111683 - 111696 .

Wang P, Li X, Wang J, Gao D, Li Y, Li H, Chu Y, Zhang Z et al. ( 2017 ) . Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent . Nat Commun vol. 8 , ( 1 ) 1395 - 1395 .

Spurrell E, Gangeswaran R, Wang P, Cao F, Gao D, Feng B, Wold W, Tollefson A et al. ( 2017 ) . Correction for Spurrell et al., “STAT1 Interaction with E3-14.7K in Monocytes Affects the Efficacy of Oncolytic Adenovirus” . Journal of Virology vol. 91 , ( 20 ) e00670 - e00617 .

Howells A, Marelli G, Lemoine NR, Wang Y ( 2017 ) . Oncolytic Viruses-Interaction of Virus and Tumor Cells in the Battle to Eliminate Cancer . Front Oncol vol. 7 , 195 - 195 .

Vincent D, Kramberger P, Hudej R, Štrancar A, Wang Y, Zhou Y, Velayudhan A ( 2017 ) . The development of a monolith-based purification process for Orthopoxvirus vaccinia virus Lister strain . Journal of Chromatography A vol. 1524 , 87 - 100 .

Cui B, Cao X, Zou W, Wan Y, Wang N, Wang Y, Li P, Hua F et al. ( 2017 ) . Regulation of immune-related diseases by multiple factors of chromatin, exosomes, microparticles, vaccines, oxidative stress, dormancy, protein quality control, inflammation and microenvironment: a meeting report .. . Acta Pharmaceutica Sinica B vol. 7 , ( 4 ) 532 - 540 .

Tysome JR, Alusi G, Lemoine N, Wang Y ( 2017 ) . Oncolytic Vaccinia Virus Gene Therapy for HNSCC . Otolaryngology vol. 139 , ( S2 ) p92 - p93 .

Lu S, Ahmed T, Du P, Wang Y ( 2017 ) . Genomic Variations in Pancreatic Cancer and Potential Opportunities for Development of New Approaches for Diagnosis and Treatment . Int J Mol Sci vol. 18 , ( 6 )

Webb ES, Liu P, BALEEIRO R, Lemoine NR, Yuan M, Wang Y ( 2017 ) . Immune checkpoint inhibitors in cancer therapy . Journal of Biomedical Research

Liu S, Ruban L, Wang Y, Zhou Y, Nesbeth DN ( 2017 ) . Establishing elements of a synthetic biology platform for Vaccinia virus production: BioBrick™ design, serum-free virus production and microcarrier-based cultivation of CV-1 cells . Heliyon vol. 3 , ( 2 ) e00238 - e00238 .

Li X, Wang P, Li H, Du X, Liu M, Huang Q, Wang Y, Wang S ( 2017 ) . The Efficacy of Oncolytic Adenovirus Is Mediated by T-cell Responses against Virus and Tumor in Syrian Hamster Model . Clinical Cancer Research vol. 23 , ( 1 ) 239 - 249 .

Yuan M, Wang P, Chard LS, Lemoine NR, Wang Y ( 2016 ) . A Simple and Efficient Approach to Construct Mutant Vaccinia Virus Vectors . Journal of Visualized Experiments ( 116 )

Yuan M, Wang P, Chard LS, Lemoine NR, Wang Y ( 2016 ) . A Simple and Efficient Approach to Construct Mutant Vaccinia Virus Vectors . Journal of Visualized Experiments ( 116 )

Yuan M, Webb E, Lemoine NR, Wang Y ( 2016 ) . CRISPR-Cas9 as a Powerful Tool for Efficient Creation of Oncolytic Viruses . Viruses vol. 8 , ( 3 )

Ibrahim AM, Wang Y-H ( 2016 ) . Viro-immune therapy: A new strategy for treatment of pancreatic cancer . World Journal of Gastroenterology vol. 22 , ( 2 ) 748 - 763 .

Yaghchi CA, Zhang Z, Alusi G, Lemoine NR, Wang Y ( 2015 ) . Vaccinia virus, a promising new therapeutic agent for pancreatic cancer . Immunotherapy vol. 7 , ( 12 ) 1249 - 1258 .

Ibrahim AM, Wang Y, Lemoine NR ( 2015 ) . Immune-checkpoint blockade: the springboard for immuno-combination therapy . Gene Therapy vol. 22 , ( 11 ) 849 - 850 .

Yuan M, Gao X, Chard LS, Ali Z, Ahmed J, Li Y, Liu P, Lemoine NR et al. ( 2015 ) . A marker-free system for highly efficient construction of vaccinia virus vectors using CRISPR Cas9 . Molecular Therapy — Methods & Clinical Development vol. 2 ,

Chard LS, Lemoine NR, Wang Y ( 2015 ) . New role of Interleukin-10 in enhancing the antitumor efficacy of oncolytic vaccinia virus for treatment of pancreatic cancer . OncoImmunology vol. 4 , ( 9 )

Browne A, Tookman LA, Ingemarsdotter CK, Bouwman RD, Pirlo K, Wang Y, McNeish IA, Lockley M ( 2015 ) . Pharmacological Inhibition of β3 Integrin Reduces the Inflammatory Toxicities Caused by Oncolytic Adenovirus without Compromising Anticancer Activity . Cancer Research vol. 75 , ( 14 ) 2811 - 2821 .

Hughes J, Wang P, Alusi G, Shi H, Chu Y, Wang J, Bhakta V, McNeish I et al. ( 2015 ) . Lister strain vaccinia virus with thymidine kinase gene deletion is a tractable platform for development of a new generation of oncolytic virus . Gene Therapy vol. 22 , ( 6 ) 476 - 484 .

Ferguson M, Tysome J, Burns E, Whitehead M, Aksoy E, Clear A, Alusi G, Hiley C et al. ( 2015 ) . 649. Targeting Innate Host Immunity Through PI3K Delta for Enhancement of Systemic Delivery of Oncolytic Vaccinia Virus . Molecular Therapy . vol. 23 , s258 - s259 .

Hughes JP, Alusi G, Wang Y ( 2015 ) . Viral gene therapy for head and neck cancer . Journal of Laryngology and Otology vol. 129 , ( 4 ) 314 - 320 .

Hughes J, Wang P, Alusi G, Shi H, Chu Y, Wang J, Bhakta V, McNeish I et al. ( 2015 ) . Lister strain vaccinia virus with thymidine kinase gene deletion is a tractable platform for development of a new generation of oncolytic virus . Gene Therapy vol. 22 , ( 6 ) 476 - 484 .

Hughes JP, Alusi G, Wang Y ( 2015 ) . Viral gene therapy for head and neck cancer . The Journal of Laryngology and Otology vol. 129 , ( 4 ) 314 - 320 .

Yuan M, Zhang W, Wang J, Yaghchi CA, Ahmed J, Chard L, Lemoine NR, Wang Y ( 2015 ) . Efficiently Editing the Vaccinia Virus Genome by Using the CRISPR-Cas9 System . Journal of Virology vol. 89 , ( 9 ) 5176 - 5179 .

Chard LS, Maniati E, Wang P, Zhang Z, Gao D, Wang J, Cao F, Ahmed J et al. ( 2015 ) . A Vaccinia Virus Armed with Interleukin-10 Is a Promising Therapeutic Agent for Treatment of Murine Pancreatic Cancer . Clinical Cancer Research vol. 21 , ( 2 ) 405 - 416 .

Hiley CT, Chard L, Tysome J, Briat A, Lemoine NR, Wang Y ( 2012 ) . Abstract A37: Increased efficacy of oncolytic vaccinia virus, an emerging therapy for pancreatic adenocarcinoma, due to intratumoral hypoxia and vascular endothelial growth factor A . Conference: Therapya37 - a37 .

Spurrell E, Gangeswaran R, Wang P, Cao F, Gao D, Feng B, Wold W, Tollefson A et al. ( 2014 ) . STAT1 interaction with E3-14.7K in monocytes affects the efficacy of oncolytic adenovirus . Journal of Virology vol. 88 , ( 4 ) 2291 - 2300 .

Hallden G, Wang Y, Wong H-H, Lemoine NR ( 2014 ) . 18: ONCOLYTIC ADENOVIRUSES FOR CANCER GENE THERAPY . Advanced Textbook on Gene Transfer, Gene Therapy and Genetic Pharmacology , vol. 1 , World Scientific Publishing

Ahmed J, Yuan M, Li Y, Chu Y, Shi H, Chard L, Alusi G, Lemoine N et al. ( 2014 ) . A Novel Tumour Selective Oncolytic Vaccinia Virus Lacking the N1L Gene Enhances the Anti-Tumour Immune Response When Used as an Anticancer Therapeutic . MOLECULAR THERAPY . vol. 22 , S248 - S249 .

Hughes J, Wang P, Alusi G, Bhakta V, Chu Y, Shi H, McNeish I, McCart A et al. ( 2014 ) . Backbone selection for development of tumour-targeted oncolyti Vaccinia virus for cancer treatment . HUMAN GENE THERAPY . vol. 25 , A22 - A23 .

Ahmed J, Yuan M, Alusi G, Lemoine NR, Wang Y ( 2014 ) . Chapter 16 The Lister Strain of Vaccinia Virus as an Anticancer Therapeutic Agent . Gene Therapy of Cancer , Elsevier

Hiley CT, Chard LS, Gangeswaran R, Tysome JR, Briat A, Lemoine NR, Wang Y ( 2013 ) . Vascular endothelial growth factor A promotes vaccinia virus entry into host cells via activation of the Akt pathway . J Virol vol. 87 , ( 5 ) 2781 - 2790 .

Chard LS, Maniati E, Wang P, Hughes J, Wang J, Denes B, Fodor I, Hagemann T et al. ( 2013 ) . A Vaccinia Virus Armed with Interleukin-10 That Dampens Host Immunity to the Vctor but Not to Tumor Is a Promising Therapeutic Agent for Pancreatic Cancer . MOLECULAR THERAPY . vol. 21 , S196 - S196 .

Hughes J, Wang P, Alusi G, Bhakta V, Chu Y, Shi H, McNeish I, McCart A et al. ( 2013 ) . Lister Strain Vaccinia Virus Demonstrates Favourable Anti-Tumor Efficacy and Tumor-Selectivity Compared to Western Reserve Strain . MOLECULAR THERAPY . vol. 21 , S216 - S216 .

Nowrouzi A, Cheung WT, Li T, Zhang X, Arens A, Paruzynski A, Waddington SN, Osejindu E et al. ( 2013 ) . The Fetal Mouse Is a Sensitive Genotoxicity Model That Exposes Lentiviral-associated Mutagenesis Resulting in Liver Oncogenesis . MOLECULAR THERAPY vol. 21 , ( 2 ) 324 - 337 .

Ahmed J, Yuan M, Alusi G, Lemoine NR, Wang Y ( 2013 ) . The Lister Strain of Vaccinia Virus as an Anticancer Therapeutic Agent . Gene Therapy of Cancer: Translational Approaches from Preclinical Studies to Clinical Implementation: Third Edition ,

Cheung W, Nowrouzi A, Coutelle C, Waddington S, Bigger B, Al Alaf F, Thrasher A, Andrews R et al. ( 2013 ) . The fetal mouse is a model of genotoxicity that can uncover genes involved in liver cancer . HUMAN GENE THERAPY . vol. 24 , A15 - A16 .

Tysome JR, Lemoine NR, Wang Y ( 2013 ) . Update on oncolytic viral therapy - targeting angiogenesis . Onco Targets Ther vol. 6 , 1031 - 1040 .

Tysome JR, Li X, Wang S, Wang P, Gao D, Du P, Chen D, Gangeswaran R et al. ( 2012 ) . A novel therapeutic regimen to eradicate established solid tumors with an effective induction of tumor-specific immunity . Clin Cancer Res vol. 18 , ( 24 ) 6679 - 6689 .

Yang Y, Li X, Wang Y, Wang S ( 2012 ) . Abstract LB-129: CD8+ T cell response mediates the therapeutic effects of oncolytic adenovirus in an immunocompetent mouse model . Cancer Research vol. 72 , ( 8_Supplement )

Ferguson MS, Lemoine NR, Wang Y ( 2012 ) . Systemic Delivery of Oncolytic Viruses: Hopes and Hurdles . Advances in Virology vol. 2012 ,

Wang P, Jiang G, Chard L, Wang J, Gao D, Cao H, Lemoine NR, Wang Y ( 2012 ) . A Rationally Designed Oncolytic Adenovirus, Ad-TD-IL-12, Cures Pancreatic Cancer in the Immunocompetent Syrian Hamster . MOLECULAR THERAPY . vol. 20 , S131 - S131 .

Yang Y, Li X, Wang Y, Wang S ( 2012 ) . CD8<SUP>+</SUP> T cell response mediates the therapeutic effects of oncolytic adenovirus in an immunocompetent mouse model . CHINESE SCIENCE BULLETIN vol. 57 , ( 1 ) 48 - 53 .

Hughes J, Alusi G, Wang Y ( 2012 ) . Gene therapy and nasopharyngeal carcinoma . RHINOLOGY vol. 50 , ( 2 ) 115 - 121 .

WANG Y ( 2012 ) . Modification of the Early Gene Enhancer-promoter Improves the Oncolytic Potency of Adenovirus 11 . Mol Ther vol. 20 , ( 2 ) 306 - 16 .

Tysome JR, Wang P, Alusi G, Briat A, Gangeswaran R, Wang J, Bhakta V, Fodor I et al. ( 2011 ) . Lister vaccine strain of vaccinia virus armed with the endostatin-angiostatin fusion gene: an oncolytic virus superior to dl1520 (ONYX-015) for human head and neck cancer . Hum Gene Ther vol. 22 , ( 9 ) 1101 - 1108 .

Jiang G, Cao F, Ren G, Gao D, Bhakta V, Zhang Y, Cao H, Dong Z et al. ( 2010 ) . PRSS3 promotes tumour growth and metastasis of human pancreatic cancer . Gut vol. 59 , ( 11 ) 1535 - 1544 .

Hiley CT, Briat A, Puttaswamaiah G, Wong HH, Lemoine NR, Wang Y ( 2010 ) . Abstract 589: Vascular endothelial growth factor facilitates vaccinia virus tropism and oncolysis in human pancreatic ductal adenocarcinoma . Cancer Research . vol. 70 , 589 - 589 .

Hiley CT, Yuan M, Lemoine NR, Wang Y ( 2010 ) . Lister strain vaccinia virus, a potential therapeutic vector targeting hypoxic tumours . Gene Ther vol. 17 , ( 2 ) 281 - 287 .

Wong HH, Lemoine NR, Wang Y ( 2010 ) . Oncolytic viruses for cancer therapy: overcoming the obstacles . Viruses vol. 2 , ( 1 ) 78 - 106 .

Tysome JR, Lemoine NR, Wang YH ( 2009 ) . Combination of anti-angiogenic therapy and virotherapy: Arming oncolytic viruses with anti-angiogenic genes . CURR OPIN MOL THER vol. 11 , ( 6 ) 664 - 669 .

Tysome JR, Briat A, Alusi G, Cao F, Gao D, Yu J, Wang P, Yang S et al. ( 2009 ) . Lister strain of vaccinia virus armed with endostatin–angiostatin fusion gene as a novel therapeutic agent for human pancreatic cancer . Gene Therapy vol. 16 , ( 10 ) 1223 - 1233 .

Wang YH, Gangeswaran R, Zhao XB, Wang PJ, Tysome J, Bhakta V, Yuan M, Chikkanna-Gowda CP et al. ( 2009 ) . CEACAM6 attenuates adenovirus infection by antagonizing viral trafficking in cancer cells . J CLIN INVEST vol. 119 , ( 6 ) 1604 - 1615 .

Tysome JR, Briat A, Hiley C, Gangeswaran R, Chikkanna-Gowda CP, Bhakta V, Alusi G, Trivedi K et al. ( 2009 ) . Systemic Delivery of Lister Strain Vaccinia Virus to Tumors Is Facilitated by the Depletion of Macrophages in Immuno-Competent Mice . MOLECULAR THERAPY . vol. 17 , S247 - S247 .

Wong HH, Gangeswaran R, Francis J, Lemoine NR, Wang Y ( 2009 ) . Adenovirus 11 is an Alternative Oncolytic Virus Targeting Adenovirus 5-Insensitive Cancer and Shows Distinct E1A Gene Transcriptional Activity . MOLECULAR THERAPY . vol. 17 , S235 - S236 .

Tysome JR, Briat A, Alusi G, Cao F, Yu J, Wang P, Yang S, Dong Z et al. ( 2009 ) . Lister strain of vaccinia virus armed with endostatin–angiostatin fusion gene as a novel therapeutic agent for human pancreatic cancerVaccine strain of vaccinia virus for cancer therapy . Gene Therapy vol. 16 , ( 10 ) 1223 - 1233 .

Kirn DH, Wang YH, Liang WC, Contag CH, Thorne SH ( 2008 ) . Enhancing poxvirus oncolytic effects through increased spread and immune evasion . CANCER RES vol. 68 , ( 7 ) 2071 - 2075 .

Cheong SC, Wang Y, Meng J-H, Hill R, Sweeney K, Kirn D, Lemoine NR, Halldén G ( 2008 ) . E1A-expressing adenoviral E3B mutants act synergistically with chemotherapeutics in immunocompetent tumor models . Cancer Gene Ther vol. 15 , ( 1 ) 40 - 50 .

Kirn DH, Wang YH, Le Boeuf F, Bell J, Thorne SH ( 2007 ) . Targeting of interferon-beta to produce a specific, multi-mechanistic oncolytic vaccinia virus . PLOS MED vol. 4 , ( 12 ) Article e353 , 2001 - 2012 .

Thorne SH, Hwang THH, O'Gorman WE, Bartlett DL, Sei S, Kanji F, Brown C, Werier J et al. ( 2007 ) . Rational strain selection and engineering creates a broad-spectrum, systemically effective oncolytic poxvirus, JX-963 . J CLIN INVEST vol. 117 , ( 11 ) 3350 - 3358 .

Lopes RB, Gangeswaran R, McNeish IA, Wang Y, Lemoine NR ( 2007 ) . Expression of the IAP protein family is dysregulated in pancreatic cancer cells and is important for resistance to chemotherapy . Int J Cancer vol. 120 , ( 11 ) 2344 - 2352 .

Bapat U, Wang Y, Alusi G, Chisholm E, Francis J, Hallden G, Lemoine N ( 2006 ) . Oncolytic virotherapy for nasopharyngeal cancer . Clinical Otolaryngology vol. 31 , ( 6 ) 582 - 583 .

Themis M, Waddington SN, Schmidt M, von Kalle C, Wang Y, Al-Allaf F, Gregory LG, Nivsarkar M et al. ( 2006 ) . Corrigendum to "Oncogenesis Following Delivery of a Nonprimate Lentiviral Gene Therapy Vector to Fetal and Neonatal Mice" . Mol Ther vol. 13 , ( 4 )

Themis M, Waddington SN, Schmidt M, von Kalle C, Wang Y, Al-Allaf F, Gregory LG, Nivsarkar M et al. ( 2006 ) . Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice (vol 12, pg 763, 2005) . MOL THER vol. 13 , ( 4 ) 830 - 830 .

Themis M, Waddington SN, Schmidt M, von Kalle C, Wang YH, Al-Allaf F, Gregory L, Nivsarkar M et al. ( 2006 ) . Oncogenesis following delivery of a non-primate lentiviral gene therapy vector to fetal mice . TOXICOLOGY . vol. 219 , 233 - 233 .

Lockley M, Fernandez M, Wang Y, Li NF, Conroy S, Lemoine N, McNeish I ( 2006 ) . Activity of the adenoviral E1A deletion mutant dl922-947 in ovarian cancer: comparison with E1A wild-type viruses, bioluminescence monitoring, and intraperitoneal delivery in icodextrin . Cancer Res vol. 66 , ( 2 ) 989 - 998 .

Themis M, Waddington SN, Schmidt M, von Kalle C, Wang Y, Al-Allaf F, Gregory L, Nivsarkar M et al. ( 2006 ) . Oncogenesis Following Delivery of Lentiviral Vectors to Fetal and Neonatal Mice . MOLECULAR THERAPY vol. 13 , S320 - S320 .

Slettenaar VIF, Van Trappen PO, Wang Y, Ayhan A, Li FN, Balkwill F, Wilson JL ( 2006 ) . The chemokine network in normal and malignant cervix: CCR4 expression by malignant human cervical epithelial cells . CANCER RESEARCH . vol. 66 ,

Themis M, Waddington SN, Schmidt M, von Kalle C, Wang YH, Al-Allaf F, Gregory LG, Nivsarkar M et al. ( 2005 ) . Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice . MOL THER vol. 12 , ( 4 ) 763 - 771 .

Liu T-C, Wang Y, Hallden G, Brooks G, Francis J, Lemoine NR, Kirn D ( 2005 ) . Functional interactions of antiapoptotic proteins and tumor necrosis factor in the context of a replication-competent adenovirus . Gene Ther vol. 12 , ( 17 ) 1333 - 1346 .

Tan PH, Beutelspacher SC, Xue S-A, Wang Y-H, Mitchell P, McAlister JC, Larkin DFP, McClure MO et al. ( 2005 ) . Modulation of human dendritic-cell function following transduction with viral vectors: implications for gene therapy . Blood vol. 105 , ( 10 ) 3824 - 3832 .

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