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Publications:  Dr Hong Wan

Houacine S, Kang A, Parkinson EK, Wan H, Fortune F(2020). Induction of p53 in keratinocyte cultures treated with Behçet's patient sera. Journal of Oral Pathology and Medicine vol. 49, (5) 435-442.
10.1111/jop.13005
https://qmro.qmul.ac.uk/xmlui/handle/123456789/65413
Uttagomol J, Ahmad US, Rehman A, Huang Y, Laly AC, Kang A, Soetaert J, Chance R et al.(2019). Evidence for the desmosomal cadherin desmoglein-3 in regulating YAP and Phospho-YAP in keratinocyte responses to mechanical forces. International Journal of Molecular Sciences vol. 20, (24)
10.3390/ijms20246221
https://qmro.qmul.ac.uk/xmlui/handle/123456789/65251
Wan H, Li X, Ahmad U, Huang Y, Uttagomol J, Rehman A, Zhou K, Warnes G et al.(2019). Desmoglein-3 acts as a pro-survival protein by suppressing reactive oxygen species and doming whilst augmenting the tight junctions in MDCK cells. Mechanisms of Ageing and Development
10.1016/j.mad.2019.111174
https://qmro.qmul.ac.uk/xmlui/handle/123456789/61285
Rehman A, Cai Y, Hünefeld C, Jedli¿ková H, Huang Y, Teck Teh M, Sharif Ahmad U, Uttagomol J et al.(2019). The desmosomal cadherin desmoglein-3 acts as a keratinocyte anti-stress protein via suppression of p53. Cell Death and Disease vol. 10, (10)
10.1038/s41419-019-1988-0
https://qmro.qmul.ac.uk/xmlui/handle/123456789/63718
Hoque Apu E, Akram SU, Rissanen J, Wan H, Salo T(2018). Desmoglein 3 - Influence on oral carcinoma cell migration and invasion. Exp Cell Res vol. 370, (2) 353-364.
10.1016/j.yexcr.2018.06.037
https://qmro.qmul.ac.uk/xmlui/handle/123456789/56954
Uttagomol J, Connelly J, Wan H (2018). Evidence for desmoglein 3 as a mechanosensor in keratinocytes. BRITISH JOURNAL OF DERMATOLOGY. vol. 178, E406-E407.
Rehman A, Cai Y, Jedlickova H, Harwood C, Bergamaschi D, Wan H (2018). Novel role of desmoglein-3 acting as a negative regulator of p53. BRITISH JOURNAL OF DERMATOLOGY. vol. 178, E417-E418.
https://qmro.qmul.ac.uk/xmlui/handle/123456789/65639
Rehman A, Cai Y, Jedliková H, Harwood C, Bergamaschi D, Wan H(2018). 1347 Desmoglein-3 acts as an anti-stress protein via suppression of p53. Journal of Investigative Dermatology vol. 138, (5) S229-S229.
10.1016/j.jid.2018.03.1364
Uttagomol J, Aguedo A, Connelly J, Wan H (2018). Desmoglein 3 acts as a mechanosensor in keratinocytes. JOURNAL OF INVESTIGATIVE DERMATOLOGY. Conference: IID vol. 138, S146-S146.
10.1016/j.jid.2018.03.869
https://qmro.qmul.ac.uk/xmlui/handle/123456789/63947
Rehman A, Cai Y, Jedlikova H, Harwood C, Bergamaschi D, Wan H (2018). Desmoglein-3 acts as an anti-stress protein via suppression of p53. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 138, S229-S229.
WAN H (2016). Desmoglein 3 acts as a potential oncogene in promoting cancer cell migration and invasion through regulating AP-1 and PKC dependent-Ezrin activation. Conference: British Skin Foundation Skin Deep-20th Anniversary Symposium (royal college of physicians, London) from: 13/10/2016 to: 13/10/2016, vol. 175, 65-66.
https://qmro.qmul.ac.uk/xmlui/handle/123456789/26004
TEH M, Wan HONG(2016). Independent Evaluation of a FOXM1-based Quantitative Malignancy Diagnostic System (qMIDS) on Head and Neck Squamous Cell Carcinomas. Oncotarget vol. 7, (34) 54555-54563.
10.18632/oncotarget.10512
https://qmro.qmul.ac.uk/xmlui/handle/123456789/13688
Mofta H, Dias K, Hoque Apu E, Liu L, Uttagomal J, Bergmeier L, Kermorgan S, Wan H(2016). Desmoglein 3 regulates membrane trafficking of cadherins, an implication in cell-cell adhesion. Cell Adhesion & Migration
10.1080/19336918.2016.1195942
https://qmro.qmul.ac.uk/xmlui/handle/123456789/17654
Wan H, Lin K, Tsang SM, Uttagomol J(2016). Evidence for Dsg3 in regulating Src signaling by competing with it for binding to caveolin-1. Data in Brief vol. 6, 124-134.
10.1016/j.dib.2015.11.049
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12355
Brown L, Wan H(2015). Desmoglein 3: a help or a hindrance in cancer progression?. Cancers (Basel) vol. 7, (1) 266-286.
10.3390/cancers7010266
WAN H(2015). Desmoglein 3: a help or a hindrance in cancer progression?. Cancers vol. Cancers 2015, (7) 266-286.
10.3390/cancers7010266
https://qmro.qmul.ac.uk/xmlui/handle/123456789/17653
Wan H, Kenny F, Connelly J(2014). DESMOGLEIN 3 ACTS AS A MECHANOSENSOR IN RESPONSE TO ENVIRONMENTAL MECHANICAL PROPERTY. ANTICANCER RESEARCH vol. 34, (10) 6238-6238.
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6751
Moftah H, Diaz K, Kermorgant S, Wan H (2014). Role for Desmoglein 3 in regulating E-cadherin trafficking. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 134, S29-S29.
Brown L, Waseem A, Cruz IN, Szary J, Gunic E, Mannan T, Unadkat M, Yang M et al.(2013). Desmoglein 3 promotes cancer cell migration and invasion by regulating activator protein 1 and protein kinase C-dependent-Ezrin activation. Oncogene vol. 33, 2363-2374.
10.1038/onc.2013.186
Teh M-T, Hutchison IL, Costea DE, Neppelberg E, Liavaag PG, Purdie K, Harwood C, Wan H et al.(2013). Exploiting FOXM1-orchestrated molecular network for early squamous cell carcinoma diagnosis and prognosis. Int J Cancer vol. 132, (9) 2095-2106.
10.1002/ijc.27886
Tsang SM, Brown L, Gadmor H, Gammon L, Fortune F, Wheeler A, Wan H(2012). Desmoglein 3 acting as an upstream regulator of Rho GTPases, Rac-1/Cdc42 in the regulation of actin organisation and dynamics. Exp Cell Res vol. 318, (18) 2269-2283.
10.1016/j.yexcr.2012.07.002
Brown LE, Gunic E, Unadkat M, Mannan T, Tsang S, Ahmed W, Valderrama F, O'Toole EA et al. (2012). Desmoglein 3 regulates cancer cell migration through Protein Kinase C dependent-ezrin activation. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 132, S37-S37.
Wan H, Brown L, Gunic E, Mannan T, Tsang S, Valderrama F, O'Toole E (2012). Desmoglein 3 Regulates Cancer Cell Migration Through PKC Dependent-ezrin Activation. EUROPEAN JOURNAL OF CANCER. vol. 48, S45-S46.
10.1016/S0959-8049(12)70885-7
Tsang SM, Brown L, Lin K, Liu L, Piper K, O'Toole EA, Grose R, Hart IR et al.(2012). Non-junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris. J Pathol vol. 227, (1) 81-93.
10.1002/path.3982
Bose A, Teh M-T, Hutchison IL, Wan H, Leigh IM, Waseem A(2012). Two mechanisms regulate keratin K15 expression in keratinocytes: role of PKC/AP-1 and FOXM1 mediated signalling. PLoS One vol. 7, (6)
10.1371/journal.pone.0038599
https://qmro.qmul.ac.uk/xmlui/handle/123456789/7876
Mannan T, Jing S, Foroushania SH, Fortune F, Wan H(2011). RNAi-mediated inhibition of the desmosomal cadherin (desmoglein 3) impairs epithelial cell proliferation. CELL PROLIFERAT vol. 44, (4) 301-310.
10.1111/j.1365-2184.2011.00765.x
Teh M-T, Parkinson EK, Thurlow JK, Liu F, Fortune F, Wan H(2011). A molecular study of desmosomes identifies a desmoglein isoform switch in head and neck squamous cell carcinoma. J Oral Pathol Med vol. 40, (1) 67-76.
10.1111/j.1600-0714.2010.00951.x
Cabral RM, Wan H, Cole CL, Abrams DJ, Kelsell DP, South AP (2010). Identification and characterisation of DSPla, a novel isoform of human desmoplakin. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 130, S16-S16.
Cabral RM, Wan H, Cole CL, Abrams DJ, Kelsell DP, South AP(2010). Identification and characterization of DSPIa, a novel isoform of human desmoplakin. CELL TISSUE RES vol. 341, (1) 121-129.
10.1007/s00441-010-0989-1
https://qmro.qmul.ac.uk/xmlui/handle/123456789/20279
Tsang S, Liu L, Teh M, Wheeler A, Piper K, Grose R, Hart I, Garrod D et al. (2010). Novel role for human desmoglein 3 in regulating E-cadherin mediated adherens junctions through Src family kinase activation. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 130, S33-S33.
Tsang SM, Liu L, Teh M-T, Wheeler A, Grose R, Hart IR, Garrod DR, Fortune F et al.(2010). Desmoglein 3, via an interaction with E-cadherin, is associated with activation of Src. PloS ONE vol. 5, (12)
10.1371/journal.pone.0014211
https://qmro.qmul.ac.uk/xmlui/handle/123456789/11130
Gemenetzidis E, Elena-Costea D, Parkinson EK, Waseem A, Wan H, Teh MT(2010). Induction of Human Epithelial Stem/Progenitor Expansion by FOXM1. Cancer Research vol. 70, (22) Article N/A, 9515-9526.
10.1158/0008-5472.CAN-10-2173
Gemenetzidis E, Bose A, Riaz AM, Chaplin T, Young BD, Ali M, Sugden D, Thurlow JK et al.(2009). FOXM1 upregulation is an early event in human squamous cell carcinoma and it is enhanced by nicotine during malignant transformation. PLoS One vol. 4, (3)
10.1371/journal.pone.0004849
https://qmro.qmul.ac.uk/xmlui/handle/123456789/11131
Wan H, South AP, Hart IR(2007). Increased keratinocyte proliferation initiated through downregulation of desmoplakin by RNA interference. Exp Cell Res vol. 313, (11) 2336-2344.
10.1016/j.yexcr.2007.01.010
Wan H, Yuan M, Simpson C, Allen K, Gavins FNE, Ikram MS, Basu S, Baksh N et al.(2007). Stem/progenitor cell-like properties of desmoglein 3dim cells in primary and immortalized keratinocyte lines. Stem Cells vol. 25, (5) 1286-1297.
10.1634/stemcells.2006-0304
Wan H, Yuan M, Simpson C, Allen K, Gavins FN, Ikram MS, Basu S, Baksh N et al. (2007). Stem/progenitor cell-like properties of Desmoglein 3dim cells in primary and immortalized keratinocyte lines. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 127, S66-S66.
Wan H, Hart IR (2005). Downregulation of desmoplakin by RNA interference in HaCaT cells results in increased cellular proliferation. BRITISH JOURNAL OF DERMATOLOGY. vol. 152, 834-834.
South AP, Wan H, Hart IR (2005). Generation of stable knockdown in keratinocyte cell lines using retrovirus-mediated RNA interference. BRITISH JOURNAL OF DERMATOLOGY. vol. 152, 846-846.
Wan H, Hart IR (2005). Specific downregulation of Desmoglein 3 by RNA interference in HaCaT keratinocyte cells causes decreased cell proliferation. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 124, A29-A29.
Wan H, Dopping-Hepenstal PJC, Gratian MJ, Stone MG, Zhu G, Purkis PE, South AP, Keane F et al.(2004). Striate palmoplantar keratoderma arising from desmoplakin and desmoglein 1 mutations is associated with contrasting perturbations of desmosomes and the keratin filament network. BRIT J DERMATOL vol. 150, (5) 878-891.
10.1111/j.1365-2133.2004.05996.x
Wan H, Stone MG, Simpson C, Reynolds LE, Marshall JF, Hart IR, Hodivala-Dilke KM, Eady RAJ(2003). Desmosomal proteins, including desmoglein 3, serve as novel negative markers for epidermal stem cell-containing population of keratinocytes. J CELL SCI vol. 116, (20) 4239-4248.
10.1242/jcs.00701
South AP, Wan H, Stone MG, Dopping-Hepenstal PJC, Purkis PE, Marshall JF, Leigh IM, Eady RAJ et al.(2003). Lack of plakophilin 1 increases keratinocyte migration and reduces desmosome stability. J CELL SCI vol. 116, (16) 3303-3314.
10.1242/jcs.00636
Wan H, Dopping-Hepenstal PJC, Gratian MJ, Stone MG, McGrath JA, Eady RAJ(2003). Desmosomes exhibit site-specific features in human palm skin. EXP DERMATOL vol. 12, (4) 378-388.
10.1034/j.1600-0625.2002.120404.x
Wan H, Marshall J, Reynolds LE, Stone MG, McGrath JA, Hodivala-Dilke KM, Eady RAJ(2002). Diversity of desmoplakin expression in basal palm keratinocytes: A possible clue to the identification of epidermal stem cells. J INVEST DERMATOL vol. 119, (3) 714-714.
South A, Wan H, Stone M, Dopping-Hepenstal P, Purkis P, Leigh I, Eady R, Hart I et al.(2002). Lack of plakophilin-1 reduces calcium stability of membrane bound desmosomal components. J INVEST DERMATOL vol. 119, (1) 226-226.
Whittock NV, Smith FJ, Wan H, Mallipeddi R, Griffiths WA, Dopping-Hepenstal P, Ashton GH, Eady RA et al.(2002). Frameshift mutation in the V2 domain of human keratin 1 results in striate palmoplantar keratoderma. J INVEST DERMATOL vol. 118, (5) 838-844.
10.1046/j.1523-1747.2002.01750.x
Hamada T, McLean WHI, Ramsay M, Ashton GHS, Nanda A, Jenkins T, Edelstein I, South AP et al.(2002). Lipoid proteinosis maps to 1q21 and is caused by mutations in the extracellular matrix protein 1 gene (ECM1). HUM MOL GENET vol. 11, (7) 833-840.
10.1093/hmg/11.7.833
Whittock NV, Wan H, Morley SM, Garzon MC, Kristal L, Hyde P, McLean WHI, Pulkkinen L et al.(2002). Compound heterozygosity for non-sense and mis-sense mutations in desmoplakin underlies skin fragility/woolly hair syndrome. J INVEST DERMATOL vol. 118, (2) 232-238.
10.1046/j.0022-202x.2001.01664.x
Wan H, Dopping-Hepenstal T, Gratian M, Stone MG, McGrath JA, Eady RAJ(2001). Desmosomes exhibit site-specific features in human palm skin. J INVEST DERMATOL vol. 117, (3) 789-789.
Whittock NV, Wan H, Smith FJD, Keane F, Mallipedi R, Griffiths WAD, Dopping-Hepenstal P, Ashton GHS et al.(2001). Frameshift mutation in the V2 domain of keratin I causes the striate form of palmoplantar keratoderma. J INVEST DERMATOL vol. 117, (3) 766-766.
Springall T, Sheerin NS, Abe K, Holers VM, Wan H, Sacks SH(2001). Epithelial secretion of C3 promotes colonization of the upper urinary tract by Escherichia coli. NAT MED vol. 7, (7) 801-806.
10.1038/89923
Wan H, Winton HL, Soeller C, Taylor GW, Gruenert DC, Thompson PJ, Cannell MB, Stewart GA et al.(2001). The transmembrane protein occludin of epithelial tight junctions is a functional target for serine peptidases from faecal pellets of Dermatophagoides pteronyssinus. CLIN EXP ALLERGY vol. 31, (2) 279-294.
10.1046/j.1365-2222.2001.00970.x
Ring PC, Wan H, Schou C, Kroll KA, Roepstorff P, Robinson C(2000). The 18-kDa form of cat allergen Felis domesticus 1 (Fel d 1) is associated with gelatin- and fibronectin-degrading activity. Clin.Exp.Allergy vol. 30, (8) 1085-1096.
Wan H, Winton HL, Soeller C, Stewart GA, Thompson PJ, Gruenert DC, Cannell MB, Garrod DR et al.(2000). Tight junction properties of the immortalized human bronchial epithelial cell lines Calu-3 and 16HBE14o-. Eur.Respir.J. vol. 15, (6) 1058-1068.
Wan H, Winton HL, Soeller C, Gruenert DC, Thompson PJ, Cannell MB, Stewart GA, Garrod DR et al.(2000). Quantitative structural and biochemical analyses of tight junction dynamics following exposure of epithelial cells to house dust mite allergen Der p 1. Clin.Exp.Allergy vol. 30, (5) 685-698.
Wan H, Winton HL, Soeller C, Tovey ER, Gruenert DC, Thompson PJ, Stewart GA, Taylor GW et al.(1999). Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. J.Clin.Invest vol. 104, (1) 123-133.
10.1172/JCI5844
Robinson C, Wan H, Winton HL, Soeller C, Cannell MB, Gruenert DC, Thompson PJ, Stewart GA et al.(1999). Cleavage of occludin by Der P 1 facilitates transepithelial permeation of allergen. AM J RESP CRIT CARE vol. 159, (3) A856-A856.
Robinson C, Wan H, Winton HL(1999). Proteinases and sensitization: house mites and enzyme detergents - Response. CLIN EXP ALLERGY vol. 29, (2) 281-282.
10.1046/j.1365-2222.1999.0533b.x
Robinson C, Wan H, Winton HL(1999). Response by Robinson, Wan and Winton. Clin.Exp.Allergy vol. 29, (2) 281-282.
Winton HL, Wan H, Cannell MB, Gruenert DC, Thompson PJ, Garrod DR, Stewart GA, Robinson C(1998). Cell lines of pulmonary and non-pulmonary origin as tools to study the effects of house dust mite proteinases on the regulation of epithelial permeability. Clin.Exp.Allergy vol. 28, (10) 1273-1285.
10.1046/j.1365-2222.1998.00354.x
Winton HL, Wan H, Cannell MB, Thompson PJ, Garrod DR, Stewart GA, Robinson C(1998). Class specific inhibition of house dust mite proteinases which cleave cell adhesion, induce cell death and which increase the permeability of lung epithelium. Br.J.Pharmacol. vol. 124, (6) 1048-1059.
Robinson C, Wan H, Winton HL(1998). Epithelial repair in asthma. Do the benefits of house dust mite avoidance result from proteinase avoidance?. Clin.Exp.Allergy vol. 28, (5) 530-533.
Wan H, Williams RL, Doherty PJ, Williams DF(1997). A study of cell behaviour on the surfaces of multifilament materials. J.Mater.Sci.Mater.Med. vol. 8, (1) 45-51.
10.1023/a:1018542313236
WAN H, WILLIAMS R, DOHERTY P, WILLIAMS DF(1994). A STUDY OF THE REPRODUCIBILITY OF THE MTT TEST. J MATER SCI-MATER M vol. 5, (3) 154-159.
10.1007/BF00053336
Wan H, Williams RL, Doherty PJ, Williams DF(1994). The cytotoxicity evaluation of Kevlar and silicon carbide by MTT assay. Journal of Material Science: Materials in Medicine vol. 5, (6-7) 441-445.
10.1007/BF00058980
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