Publications: Prof Timothy Warner
Vadgama A, Boot J, Dark N, Allan HE, Mein CA, Armstrong PC, Warner TD
(
2024
)
.
Multiparameter phenotyping of platelets and characterization of the effects of agonists using machine learning
.
Research and Practice in Thrombosis and Haemostasis
vol.
8
,
(
5
)
Chan MV, Chen M-H, Thibord F, Nkambule BB, Lachapelle AR, Grech J, Schneider ZE, de Melendez CW et al.
(
2024
)
.
Factors that modulate platelet reactivity as measured by 5 assay platforms in 3429 individuals
.
Research and Practice in Thrombosis and Haemostasis
vol.
8
,
(
3
)
Alasmari AM, Alsulayyim AS, Alghamdi SM, Philip KEJ, Buttery SC, Banya WAS, Polkey MI, Armstrong PC et al.
(
2023
)
.
Oral nitrate supplementation improves cardiovascular risk markers in COPD: ON-BC, a randomised controlled trial
.
European Respiratory Journal
vol.
63
,
(
2
)
Schofield H, Rossetto A, Armstrong PC, Allan HE, Warner TD, Brohi K, Vulliamy P
(
2023
)
.
Immature platelet dynamics are associated with clinical outcomes after major trauma
.
Journal of Thrombosis and Haemostasis
vol.
22
,
(
4
)
926
-
935
.
Allan H, Dark N, Ferreira P, Crescente M, Armstrong P, Warner T
(
2023
)
.
PB0878 Platelet-Derived Mitochondria Promote Neutrophil Activation and NETosis
.
Research and Practice in Thrombosis and Haemostasis
vol.
7
,
Schofield H, Rossetto A, Armstrong PC, Allan HE, Warner TD, Brohi K, Vulliamy P
(
2023
)
.
Immature platelet dynamics are associated with clinical outcomes after major trauma
.
Chan MV, Lordkipanidzé M, Warner TD
(
2023
)
.
Assessment of Platelet Function by High-Throughput Screening Light Transmission Aggregometry: Optimul Assay
.
Methods in Molecular Biology
vol.
2663
,
627
-
636
.
Allan HE, Vadgama A, Armstrong PC, Warner TD
(
2023
)
.
What can we learn from senescent platelets, their transcriptomes and proteomes?
.
Platelets
vol.
34
,
(
1
)
Ferreira P, Vaja R, Lopes-Pires M, Crescente M, Yu H, Nüsing R, Liu B, Zhou Y et al.
(
2023
)
.
Renal Function Underpins the Cyclooxygenase-2: Asymmetric Dimethylarginine Axis in Mouse and Man
.
Kidney International Reports
vol.
8
,
(
6
)
1231
-
1238
.
Cappelletto A, Allan HE, Crescente M, Schneider E, Bussani R, Ali H, Secco I, Vodret S et al.
(
2023
)
.
SARS-CoV-2 Spike protein activates TMEM16F-mediated platelet procoagulant activity
.
Frontiers in Cardiovascular Medicine
vol.
9
,
Gutmann C, Barwari T, Schulte C, Singh B, Theofilatos K, Joshi A, Chan M, Armstrong P et al.
(
2023
)
.
Assessing Non-coding RNAs as Markers of Platelet Reactivity in the Bruneck Study
.
WIENER KLINISCHE WOCHENSCHRIFT
.
vol.
135
,
S337
-
S338
.
Allan HE, Vadgama A, Armstrong PC, Warner TD
(
2022
)
.
Platelet ageing: A review
.
Thrombosis Research
vol.
231
,
214
-
222
.
Armstrong PC, Allan HE, Kirkby NS, Gutmann C, Joshi A, Crescente M, Mitchell JA, Mayr M et al.
(
2022
)
.
Temporal in vivo platelet labeling in mice reveals age-dependent receptor expression and conservation of specific mRNAs
.
Blood Advances
vol.
6
,
(
23
)
6028
-
6038
.
Ferreira PM, Kirkby N, Vaja R, Pires ML, Crescente M, Liu B, Yu H, Chan M et al.
(
2022
)
.
Abstract 14913: Renal Function Underpins Cox-2: Methylarginine Axis in Mouse and Man
.
Circulation
vol.
146
,
(
Suppl_1
)
a14913
-
a14913
.
Gutmann C, Barwari T, Schulte C, Singh B, Theofilatos K, Joshi A, Zampetaki A, Chan MV et al.
(
2022
)
.
Oral Presentation No. 093 Assessing different noncoding RNAs as markers of platelet reactivity
.
Cardiovascular Research
.
vol.
118
,
Doykov I, Baldwin T, Spiewak J, Gilmour KC, Gibbons JM, Pade C, Reynolds CJ, McKnight Á et al.
(
2022
)
.
Quantitative, multiplexed, targeted proteomics for ascertaining variant specific SARS-CoV-2 antibody response
.
Cell Reports Methods
vol.
2
,
(
9
)
Hsu H, Chan MV, Armstrong PC, Crescente M, Donikian D, Kondo M, Brighton T, Chen V et al.
(
2022
)
.
A pilot study assessing the implementation of 96-well plate-based aggregometry (Optimul) in Australia
.
Pathology
vol.
54
,
(
6
)
746
-
754
.
Gutmann C, Barwari T, Schulte C, Singh B, Theofilatos K, Joshi A, Zampetaki A, Chan M et al.
(
2022
)
.
MicroRNA biomarkers of platelet function
.
Cardiovascular Research
.
vol.
118
,
Grech J, Chan MV, Ochin C, Lachapelle A, Thibord F, Schneider Z, Nkambule BB, Armstrong PCJ et al.
(
2022
)
.
Serotonin-affecting antidepressant use in relation to platelet reactivity
.
Clin Pharmacol Ther
Gutmann C, Barwari T, Schulte C, Singh B, Theofilatos K, Joshi A, Zampetaki A, Chan MV et al.
(
2022
)
.
Assessing different noncoding RNAs as markers of platelet reactivity
.
CARDIOVASCULAR RESEARCH
.
vol.
118
,
Joshi A, Schmidt LE, Burnap SA, Lu R, Chan MV, Armstrong PC, Baig F, Gutmann C et al.
(
2022
)
.
Neutrophil-Derived Protein S100A8/A9 Alters the Platelet Proteome in Acute Myocardial Infarction and Is Associated With Changes in Platelet Reactivity
.
Arterioscler Thromb Vasc Biol
vol.
42
,
(
1
)
49
-
62
.
Ferreira PM, Kirkby N, Vaja R, Pires ML, Crescente M, Liu B, Yu H, Chan M et al.
(
2022
)
.
Renal Function Underpins Cox-2: Methylarginine Axis in Mouse and Man
.
CIRCULATION
.
vol.
146
,
Shih C, Chan MV, Kirkby NS, Vojnovic I, Mitchell JA, Armstrong PC, Warner TD
(
2021
)
.
Platelet inhibition by P2Y12 antagonists is potentiated by adenosine signalling activators
.
British Journal of Pharmacology
vol.
178
,
(
23
)
4758
-
4771
.
Allan HE, Hayman MA, Marcone S, Chan MV, Edin ML, Maffucci T, Joshi A, Menke L et al.
(
2021
)
.
Proteome and functional decline as platelets age in the circulation
.
Journal of Thrombosis and Haemostasis
vol.
19
,
(
12
)
3095
-
3112
.
Palma‐Barqueros V, Crescente M, de la Morena ME, Chan MV, Almarza E, Revilla N, Bohdan N, Miñano A et al.
(
2021
)
.
A novel genetic variant in PTGS1 affects N‐glycosylation of cyclooxygenase‐1 causing a dominant‐negative effect on platelet function and bleeding diathesis
.
American Journal of Hematology
vol.
96
,
(
3
)
e83
-
e88
.
Allan HE, Crescente M, Warner TD
(
2018
)
.
Investigating the behaviour of mitochondria following platelet activation
.
Proceedings for Annual Meeting of The Japanese Pharmacological Society
.
vol.
WCP2018
,
Chan MV, Barwari T, Huffman D, Armstrong PC, Santer P, Kiechl S, Willeit J, Mayr M et al.
(
2018
)
.
Platelet reactivity in an elderly and healthy population
.
Proceedings for Annual Meeting of The Japanese Pharmacological Society
.
vol.
WCP2018
,
or25
-
or22
.
Crescente M, Armstrong PC, Chan MV, Edin ML, Maffucci T, Kirkby NS, Mitchell JA, Zeldin DC et al.
(
2018
)
.
Understanding the cardiovascular effects of low dose aspirin by using a platelet COX-1-/- mouse model
.
Proceedings for Annual Meeting of The Japanese Pharmacological Society
.
vol.
WCP2018
,
Mitchell JA, Kirkby NS, Ahmetaj-Shala B, Armstrong PC, Crescente M, Ferreira P, Lopes Pires ME, Vaja R et al.
(
2020
)
.
Cyclooxygenases and the cardiovascular system
.
Pharmacology & Therapeutics
vol.
217
,
Crescente M, Armstrong PC, Kirkby NS, Edin ML, Chan MV, Lih FB, Jiao J, Maffucci T et al.
(
2020
)
.
Profiling the eicosanoid networks that underlie the anti- and pro-thrombotic effects of aspirin
.
The FASEB Journal
Vulliamy P, Montague SJ, Gillespie S, Chan MV, Coupland LA, Andrews RK, Warner TD, Gardiner EE et al.
(
2020
)
.
Loss of GPVI and GPIbα contributes to trauma-induced platelet dysfunction in severely injured patients
.
Blood Advances
vol.
4
,
(
12
)
2623
-
2630
.
Armstrong P, Ferreira PM, Chan M, Lundberg Slingsby M, Crescente M, Shih C, Kirkby N, Hobbs A et al.
(
2020
)
.
Combination of cyclic nucleotide modulators with P2Y12 receptor antagonists as anti-platelet therapy
.
Journal of Thrombosis and Haemostasis
Chan MV, Chen M-H, Barwari T, Huffman JE, Armstrong PC, Hwang S-J, Santer P, Wierer B et al.
(
2020
)
.
Platelet Reactivity in Individuals Over 65 Years Old Is not Modulated by Age
.
Circulation Research
Chan MV, Hayman MA, Sivapalaratnam S, Crescente M, Allan HE, Edin ML, Zeldin DC, Milne GL et al.
(
2020
)
.
Identification of a homozygous recessive variant in <i>PTGS1</i> resulting in a congenital aspirin-like defect in platelet function
.
Haematologica
vol.
106
,
(
5
)
1423
-
1432
.
Paterson GG, Young JM, Willson JA, Graham CJ, Dru RC, Lee EW, Torpey GS, Walmsley SR et al.
(
2020
)
.
Hypoxia Modulates Platelet Purinergic Signalling Pathways
.
Thrombosis and Haemostasis
vol.
120
,
(
2
)
253
-
261
.
Palma-Barqueros V, Chan M, Crescente M, Bastida JM, Almarza E, Varela SS, Mesa-Núñez C, Casas-Avilés I et al.
(
2019
)
.
A New Molecular Variant in the PTGS1 Gene That Abrogates Generation of Thromboxane A2 Synthesis and Associates with Platelet Dysfunction and Bleeding
.
Blood
.
vol.
134
,
Mitchell JA, Shala F, Elghazouli Y, Warner TD, Gaston-Massuet C, Crescente M, Armstrong PC, Herschman HR et al.
(
2019
)
.
Cell-Specific Gene Deletion Reveals the Antithrombotic Function of COX1 and Explains the Vascular COX1/Prostacyclin Paradox
.
Circulation Research
vol.
125
,
(
9
)
847
-
854
.
Vulliamy P, Gillespie S, Armstrong P, Allan H, Warner T, Brohi K
(
2019
)
.
Histone H4 induces platelet ballooning and microparticle release during trauma hemorrhage
.
Proceedings of the National Academy of Sciences
Houde M, Carrier É, Grandbois M, Bkaily G, Warner TD, Korporaal SJA, Van Eck M, D'Orléans-Juste P
(
2019
)
.
Altered Inhibition Of Platelet Aggregation In Hypercholerolemia In Mice And Humans
.
Atherosclerosis
.
vol.
287
,
e109
-
e110
.
Patel D, Warner TD, Armstrong PC
(
2019
)
.
ICAM-1 contributes to the preferential binding of platelets to classical and intermediate monocyte subsets over neutrophils
.
BRITISH JOURNAL OF PHARMACOLOGY
.
Conference:
Pharmacology 2018
from:
20/12/2018
to:
18/12/2018
,
vol.
176
,
3038
-
3039
.
Lucotti S, Cerutti C, Soyer M, Gil-Bernabé AM, Gomes AL, Allen PD, Smart S, Markelc B et al.
(
2019
)
.
Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A2
.
Journal of Clinical Investigation
vol.
129
,
(
5
)
1845
-
1862
.
Menke L, Marcone S, Allan H, Godson C, Warner T
(
2019
)
.
Dihomo-gamma-linolenic acid alters the proteomic releasate profile and reduces platelet reactivity
.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
.
vol.
49
,
132
-
132
.
Mazi SI, Ahmetaj-Shala B, Warner TD, Mitchell JA, Kirkby NS
(
2019
)
.
Omic profiling in healthy volunteers taking celecoxib reveals novel biomarkers regulated by cyclooxygenase-2
.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
.
vol.
85
,
1628
-
1628
.
Allan HE, Ferreira PMF, Crescente M, Warner TD
(
2019
)
.
Platelet Activation Causes Vesicle Release and Loss of Mitochondria
.
CARDIOVASCULAR DRUGS AND THERAPY
.
vol.
33
,
268
-
268
.
Sivapalaratnam S, Melissa H, Lentaigne C, Chan M, Crescente M, Allan H, Wedderburn K, Hanif M et al.
(
2018
)
.
Congenital Aspirin-like Defect As a Result of Autosomal Recessive Variants in PTGS1
.
Blood
.
vol.
132
,
Barwari T, Eminaga S, Mayr U, Lu R, Armstrong PC, Chan MV, Sahraei M, Fernández-Fuertes M et al.
(
2018
)
.
Inhibition of profibrotic microRNA-21 affects platelets and their releasate
.
JCI Insight
vol.
3
,
(
21
)
Warner T, Halford G, Watson S
(
2018
)
.
In celebration of Professor Gus Born's life, 29 July 1921 - 16 April 2018
.
Platelets
vol.
29
,
(
8
)
743
-
743
.
Hayman M, Armstrong P, Chan M, Warner T
(
2017
)
.
Functional Analyses of Reticulated Platelets
.
The FASEB Journal
.
vol.
31
,
Knowles RB, Warner TD
(
2018
)
.
Anti-platelet drugs and their necessary interaction with endothelial mediators and platelet cyclic nucleotides for therapeutic efficacy
.
Pharmacol Ther
vol.
193
,
83
-
90
.
Barwari T, Eminaga S, Lu R, Armstrong PC, Schulte C, Lynch M, Chan MV, Barallobre-Barreiro J et al.
(
2018
)
.
Abstract 300: MicroRNA-21 Affects Platelets and Their Releasate: A Novel Mechanism for the Anti-Fibrotic Effects of MicroRNA-21 Inhibition
.
Circulation Research
.
vol.
123
,
Lucotti S, Cerutti C, Soyer M, Gil-Bernabé AM, Gomes AL, Allen PD, Smart S, Markelc B et al.
(
2018
)
.
Abstract 4196: Aspirin inhibits metastasis in the intravascular phase through the blockade of COX-1-TXA2 pathway in platelets
.
Cancer Research
.
vol.
78
,
4196
-
4196
.
Barwari T, Eminaga S, Armstrong P, Chan M, Lu R, Barallobre-Barreiro J, Yin X, Pechlaner R et al.
(
2018
)
.
82 Microrna-21 regulates transforming growth factor beta-1 release from platelets
.
Heart
.
Conference:
Basic Science
vol.
104
,
Mitchell JA, Knowles RB, Kirkby NS, Reed DM, Edin ML, White WE, Chan MV, Longhurst H et al.
(
2018
)
.
Letter by Mitchell et al Regarding Article, “Urinary Prostaglandin Metabolites
.
Circulation Research
vol.
122
,
(
10
)
e84
-
e85
.
Chan MV, Leadbeater PD, Watson SP, Warner TD
(
2018
)
.
Not all light transmission aggregation assays are created equal: qualitative differences between light transmission and 96-well plate aggregometry
.
Platelets1
-
4
.
Crescente M, Menke L, Chan MV, Armstrong PC, Warner TD
(
2018
)
.
Eicosanoids in platelets and the effect of their modulation by aspirin in the cardiovascular system (and beyond)
.
British Journal of Pharmacology
vol.
176
,
(
8
)
988
-
999
.
Chan MV, Armstrong PC, Warner TD
(
2018
)
.
96-well plate-based aggregometry
.
Platelets1
-
6
.
Mitchell JA, Knowles RB, Kirkby NS, Reed DM, Edin ML, White WE, Chan MV, Longhurst H et al.
(
2018
)
.
Kidney Transplantation in a Patient Lacking Cytosolic Phospholipase A2 Proves Renal Origins of Urinary PGI-M and TX-M
.
Circulation Research
vol.
122
,
(
4
)
555
-
559
.
Lundberg Slingsby MH, Gliemann L, Thrane M, Rytter N, Egelund J, CHAN MV, Armstrong PC, Warner TD et al.
(
2018
)
.
Platelet responses to pharmacological and physiological interventions in middle-aged men with different habitual physical activity levels
.
Acta Physiol (Oxf)
VULLIAMY P, GILLESPIE S, ARMSTRONG P, CHAN M, DAVENPORT R, WARNER T, BROHI K
(
2017
)
.
Platelets Shift Towards a Procoagulant and Proin ammatory Phenotype at the Expense of Aggregation During Trauma Hemorrhage: a Potential Role of Extracellular Histones
.
Circulation
.
Conference:
American Heart Association Scientific Sessions
(
Anaheim, CA
)
from:
11/11/2017
to:
15/11/2017
,
vol.
e448-467
,
Scagliotti V, Gutierrez LP, Gualtieri A, Jimenez F, Kirkby N, Mitchell J, Warner T, Gevers E et al.
.
Cyclooxygenase-2 is a potential target for the treatment of Adamantinomatous craniopharyngioma
.
Endocrine Abstracts
.
Carrier É, Houde M, Grandbois M, Bkaily G, Warner TD, D’Orléans-Juste P
(
2017
)
.
Inhibition of platelet aggregation ex vivo is repressed in apolipoprotein E deficient mice1
.
Canadian Journal of Physiology and Pharmacology
vol.
95
,
(
8
)
954
-
960
.
Unsworth AJ, Bye AP, Tannetta DS, Desborough MJR, Kriek N, Sage T, Allan HE, Crescente M et al.
(
2017
)
.
Farnesoid X Receptor and Liver X Receptor Ligands Initiate Formation of Coated Platelets
.
Arterioscler Thromb Vasc Biol
vol.
37
,
(
8
)
1482
-
1493
.
Crescente M, Armstrong PC, CHAN MV, Edin ML, Lih FB, Jiao J, Gaston-Massuet C, Cottrell GS et al.
(
2017
)
.
PLATELET COX-1 KNOCKOUT MOUSE AS A MODEL OF THE EFFECTS OF ASPIRIN IN THE CARDIOVASCULAR SYSTEM
.
HEART
.
Conference:
BCS Annual Conference, ‘Cardiology at the Extremes'
vol.
103
,
A108
-
A109
.
Knowles RB, Lawrence MJ, Ferreira PM, Hayman MA, D'Silva LA, Stanford SN, Sabra A, Tucker AT et al.
(
2017
)
.
Platelet reactivity influences clot structure as assessed by fractal analysis of viscoelastic properties
.
Platelets1
-
9
.
ARMSTRONG PCJ, hoefer T, knowles RB, Tucker AT, Hayman MA, Ferreira PM, Chan MV, Warner TD
(
2017
)
.
Newly Formed Reticulated Platelets Undermine Pharmacokinetically Short-Lived Antiplatelet Therapies
.
Arteriosclerosis, Thrombosis, and Vascular Biology
Ahmetaj-Shala B, Tesfai A, Constantinou C, Leszczynski R, Chan MV, Gashaw H, Galaris G, Mazi S et al.
(
2017
)
.
Pharmacological assessment of ibuprofen arginate on platelet aggregation and colon cancer cell killing
.
Biochemical and Biophysical Research Communications
vol.
484
,
(
4
)
762
-
766
.
Barwari T, Eminaga S, Armstrong PC, Chan MV, Lu R, Barallobre-Barreiro J, Yin X, Pechlaner R et al.
(
2017
)
.
MicroRNA-21 Regulates Transforming Growth Factor Beta-1 Release From Platelets: A Novel Mechanism for the Anti-Fibrotic Effects of MicroRNA-21 Inhibition
.
CIRCULATION
.
vol.
136
,
Mitchell JA, Shala F, Ahmetaj-Shala B, Jiao J, Armstrong PC, Chan MV, Crescente M, Warner TD et al.
(
2017
)
.
Novel Tissue-specific Cyclooxygenase-1 Knockout Mice Demonstrate a Dominant Role for Endothelial Cyclooxygenase-1 in Prostacyclin Production
.
CIRCULATION
.
vol.
136
,
Vulliamy P, Gillespie S, Armstrong PC, Chan MV, Davenport RA, Warner TD, Brohi K
(
2017
)
.
Platelets Shift Towards a Procoagulant and Proinflammatory Phenotype at the Expense of Aggregation During Trauma Hemorrhage: a Potential Role of Extracellular Histones
.
CIRCULATION
.
vol.
136
,
E464
-
E464
.
Watson SP, Daly ME, Harrison P, Lowe GC, Paterson A, Rivera J, Warner TD, Morgan NV
(
2016
)
.
ISTH Advanced Training Course on platelet bleeding disorders: How should they be investigated?
.
Platelets
vol.
27
,
(
8
)
719
-
721
.
Kirkby NS, Reed DM, Edin ML, Rauzi F, Mataragka S, Vojnovic I, Bishop‐Bailey D, Milne GL et al.
(
2016
)
.
Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation
.
The FASEB Journal
vol.
29
,
(
11
)
4568
-
4578
.
Rauzi F, Kirkby NS, Edin ML, Whiteford J, Zeldin DC, Mitchell JA, Warner TD
(
2016
)
.
Aspirin inhibits the production of proangiogenic 15(S)-HETE by platelet cyclooxygenase-1
.
The FASEB Journal
Ferreira P, Armstrong P, Chan M, Warner T
(
2016
)
.
169 Soluble Guanylate Cyclase Activators as Combination Anti-Platelet Therapy with P2Y12 Inhibitors and PDE Inhibitors: In vivo and Ex vivo Studies
.
Heart
.
vol.
102
,
Knowles R, D’Silva L, Armstrong P, Chan M, Lawrence M, Standford S, Sabre A, Tucker A et al.
(
2016
)
.
186 Platelets as Key Regulators of Fibrin-Clot Architecture as Assessed by Fractal Analysis of Viscoelastic Properties; Effects of Standard Anti-Platelet Therapies
.
Heart
.
vol.
102
,
Hinz C, Aldrovandi M, Uhlson C, Marnett LJ, Longhurst HJ, Warner TD, Alam S, Slatter DA et al.
(
2016
)
.
Human platelets utilize cycloxygenase-1 to generate dioxolane A3, a neutrophil activating eicosanoid
.
Journal of Biological Chemistry
Article
jbc.M115.700609
,
Knowles R, D’Silva L, Stanford S, Armstrong P, Chan M, Tucker A, Ferreira P, Sabra A et al.
(
2016
)
.
INSIGHTS INTO THE ROLE OF PLATELETS IN FIBRIN CLOT FORMATION AND THE EFFICACY OF ANTI-PLATELET THERAPIES
.
Journal of the American College of Cardiology
.
vol.
67
,
Warner TD, Armstrong PC, Chan MV, Knowles RB
(
2016
)
.
The importance of endothelium-derived mediators to the efficacy of dual anti-platelet therapy
.
Expert Review of Hematology
vol.
9
,
(
3
)
223
-
225
.
Chan MV, Knowles RBM, Lundberg MH, Tucker AT, Mohamed NA, Kirkby NS, Armstrong PCJ, Mitchell JA et al.
(
2016
)
.
P2Y12 receptor blockade synergizes strongly with nitric oxide and prostacyclin to inhibit platelet activation
.
British Journal of Clinical Pharmacology
vol.
81
,
(
4
)
621
-
633
.
Mitchell JA, Knowles R, Kirkby NS, Reed DM, White W, Edin ML, Longhurst H, Yaqoob M et al.
(
2016
)
.
Kidney Transplantation in a Patient Lacking Cytosolic Phospholipase A<sub>2</sub> Leads to Urinary Prostacyclin and Thromboxane A<sub>2</sub> Metabolites Within Normal Ranges
.
CIRCULATION
.
vol.
134
,
Kaudewitz D, Skroblin P, Bender LH, Barwari T, Willeit P, Pechlaner R, Sunderland NP, Willeit K et al.
(
2015
)
.
Association of MicroRNAs and YRNAs With Platelet Function
.
Circulation Research
vol.
118
,
(
3
)
420
-
432
.
Floyd CN, Warner TD, Ferro A
(
2015
)
.
Expression of the PlA2 allele of glycoprotein IIIa and its impact on platelet function
.
JRSM Cardiovascular Disease
vol.
4
,
Ahmetaj-Shala B, Kirkby NS, Knowles R, Al'Yamani M, Mazi S, Wang Z, Tucker AT, Mackenzie LS et al.
(
2015
)
.
Reply to Letter Regarding Article, “Evidence That Links Loss of Cyclooxygenase-2 With Increased Asymmetric Dimethylarginine
.
Circulation
vol.
132
,
(
17
)
e213
-
e214
.
Hoefer T, Armstrong PC, Finsterbusch M, Chan MV, Kirkby NS, Warner TD
(
2015
)
.
Drug-Free Platelets Can Act as Seeds for Aggregate Formation During Antiplatelet Therapy
.
Arteriosclerosis Thrombosis and Vascular Biology
vol.
35
,
(
10
)
2122
-
2133
.
Armstrong PCJ, Kirkby NS, Chan MV, Finsterbusch M, Hogg N, Nourshargh S, Warner TD
(
2015
)
.
Novel whole blood assay for phenotyping platelet reactivity in mice identifies ICAM-1 as a mediator of platelet-monocyte interaction
.
Blood
vol.
126
,
(
10
)
e11
-
e18
.
Knowles R, Chan M, Hayman M, Armstrong P, Tucker A, Timmis A, Warner T
(
2015
)
.
158 The Anti-Platelet Effectiveness of P2Y12 Receptor Blockade is Strongly Influenced by the Endothelium-Derived Mediators Nitric Oxide and Prostacyclin
.
Heart
vol.
101
,
(
Suppl 4
)
Knowles R, Chan M, Lundberg M, Kirkby N, Shih C-C, Armstrong P, Hayman M, Vojnovic I et al.
(
2015
)
.
213 Synergy between Endothelial Mediators and P2Y12 Receptor Blockade as a Potential Determinant in Tailoring Anti-Platelet Therapy
.
Heart
.
vol.
101
,
Rull G, Mohd-Zain Z, Shiel J, Lundberg MH, Collier DJ, Johnston A, Warner TD, Corder R
(
2015
)
.
Effects of High Flavanol Dark Chocolate on Cardiovascular Function and Platelet Aggregation
.
Vascular pharmacology
Khanna V, Armstrong PCJ, Warner TD, Curzen N
(
2015
)
.
Prostaglandin E1 potentiates the effects of P2Y12 blockade on ADP-mediated platelet aggregation in vitro: Insights using short thromboelastography
.
Platelets
vol.
26
,
(
7
)
689
-
692
.
Ross CL, Galloway-Phillipps N, Armstrong PC, Mitchell JA, Warner TD, Brearley C, Ito M, Tunstall T et al.
(
2015
)
.
Protocol for a human in vivo model of acute cigarette smoke inhalation challenge in smokers with COPD: monitoring the nasal and systemic immune response using a network biology approach
.
BMJ Open
vol.
5
,
(
1
)
Rauzi F, Kirkby N, Edin M, Zeldin D, Whiteford J, Mitchell J, Warner T
(
2015
)
.
15(S)-HETE is a pro-angiogenic factor produced by platelets through COX-1
.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
.
vol.
13
,
225
-
225
.
Armstrong PC, Warner TD
(
2015
)
.
Characterising cell-type interactions following platelet activation in a novel low volume whole blood assay
.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
.
vol.
13
,
657
-
657
.
Ahmetaj-Shala B, Kirkby NS, Knowles R, Al'Yamani M, Mazi S, Wang Z, Tucker AT, Mackenzie L et al.
(
2015
)
.
Evidence That Links Loss of Cyclooxygenase-2 With Increased Asymmetric Dimethylarginine Novel Explanation of Cardiovascular Side Effects Associated With Anti-Inflammatory Drugs
.
CIRCULATION
vol.
131
,
(
7
)
633
-
U113
.
Knowles R, Chan M, Hayman M, Armstrong P, Tucker A, Timmis A, Warner T
(
2015
)
.
THE ANTI-PLATELET EFFECTIVENESS OF P2Y12 RECEPTOR BLOCKADE IS STRONGLY INFLUENCED BY THE ENDOTHELIUM- DERIVED MEDIATORS NITRIC OXIDE AND PROSTACYCLIN
.
HEART
.
vol.
101
,
A90
-
A91
.
Knowles RB, Chan MV, Armstrong PC, Shih C-C, Hayman MA, Vojnovic I, Tucker AT, Timmis AD et al.
(
2015
)
.
The effectiveness of P2Y12 receptor blockade is strongly determined by the presence of endothelial Mediators prostacyclin and nitric oxide
.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
.
vol.
13
,
784
-
784
.
Bender L, Mayr M, Kaudewitz D, Skroblin P, Willeit P, Morton A, Gracio F, Dudek K et al.
(
2014
)
.
Plasma microRNA levels in patients with acute coronary syndrome are associated with platelet function
.
Atherosclerosis
.
vol.
237
,
Hoefer T, Warner TD
(
2014
)
.
Abstract 19437: Elevated Platelet Turnover in Patients Receiving Dual Antiplatlet Therapy Could Permit the Formation of Uninhibited Platelet Clusters That Act as Seeds for Thrombus Formation
.
Circulation
vol.
130
,
(
suppl_2
)
Lordkipanidze M, Dovlatova N, Algahtani M, Lundberg MH, Warner TD, Fox SC, Watson SP
(
2014
)
.
Abstract 571: A Novel High-Throughput Whole Blood Immuno-Counting Assay is Useful in the Assessment of Platelet Responses to Antiplatelet Therapy
.
Arteriosclerosis Thrombosis and Vascular Biology
vol.
34
,
(
suppl_1
)
Lordkipanidze M, Dovlatova N, Algahtani M, Lundberg MH, Warner TD, Fox SC, Watson SP
(
2014
)
.
A Novel High-Throughput Whole Blood Immuno-Counting Assay is Useful in the Assessment of Platelet Responses to Antiplatelet Therapy
.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
.
vol.
34
,
Kirkby NS, Lundberg MH, Wright WR, Warner TD, Paul-Clark MJ, Mitchell JA
(
2014
)
.
COX-2 protects against atherosclerosis independently of local vascular prostacyclin: identification of COX-2 associated pathways implicate Rgl1 and lymphocyte networks
.
PLoS One
vol.
9
,
(
6
)
Lordkipanidze M, Lowe GC, Kirkby NS, Chan MV, Lundberg MH, Morgan NV, Bem D, Nisar SP et al.
(
2014
)
.
Characterization of multiple platelet activation pathways in patients with bleeding as a high-throughput screening option: use of 96-well <i>Optimul</i> assay
.
BLOOD
vol.
123
,
(
8
)
E11
-
E22
.
Brooke MA, Longhurst HJ, Plagnol V, Kirkby NS, Mitchell JA, Rüschendorf F, Warner TD, Kelsell DP et al.
(
2014
)
.
Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-α
.
Gut
vol.
63
,
(
1
)
96
-
104
.
Hoefer T, Warner TD
(
2014
)
.
Elevated Platelet Turnover in Patients Receiving Dual Antiplatlet Therapy Could Permit the Formation of Uninhibited Platelet Clusters That Act as Seeds for Thrombus Formation
.
CIRCULATION
.
vol.
130
,
Knowles RB, Chan MV, Armstrong PC, Shih C-C, Hayman MA, Vojnovic I, Tucker AT, Timmis AD et al.
(
2014
)
.
The Effectiveness of P2Y12 Receptor Antagonist Therapy is Strongly Determined by Endothelial Mediators of Platelet Function
.
CIRCULATION
.
vol.
130
,
Kaudewitz D, Lee R, Willeit P, Zampetaki A, Morton AC, Warner TD, Storey RF, Channon K et al.
(
2013
)
.
Abstract 18427: Impact of Medication on Quantification of Plasma MicroRNAs in Patients With Cardiovascular Disease
.
Circulation
vol.
128
,
(
suppl_22
)
Kirkby NS, Chan MV, Lundberg MH, Massey KA, Edmands WMB, Mackenzie LS, Holmes E, Nicolaou A et al.
(
2013
)
.
Aspirin-triggered 15-epi-lipoxin A<inf>4</inf> predicts cyclooxygenase-2 in the lungs of LPS-treated mice but not in the circulation: Implications for a clinical test
.
FASEB Journal
vol.
27
,
(
10
)
3938
-
3946
.
Kirkby NS, Lundberg MH, Chan MV, Vojnovic I, Solomon AB, Emerson M, Mitchell JA, Warner TD
(
2013
)
.
Blockade of the purinergic P2Y12 receptor greatly increases the platelet inhibitory actions of nitric oxide
.
Proc Natl Acad Sci U S A
vol.
110
,
(
39
)
15782
-
15787
.
Kirkby NS, Zaiss AK, Wright WR, Jiao J, Chan MV, Warner TD, Herschman HR, Mitchell JA
(
2013
)
.
Differential COX-2 induction by viral and bacterial PAMPs: Consequences for cytokine and interferon responses and implications for anti-viral COX-2 directed therapies
.
Biochem Biophys Res Commun
vol.
438
,
(
2
)
249
-
256
.
Willeit P, Zampetaki A, Kaudewitz D, Lee R, Dudek K, King A, Kirkby NS, Markus HS et al.
(
2013
)
.
265 PLASMA MICRORNAS AS BIOMARKERS FOR PLATELET INHIBITION
.
Heart
.
vol.
99
,
Mitchell JA, Warner TD
(
2013
)
.
Reply to Ricciotti et al.: Evidence for vascular COX isoforms
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
vol.
110
,
(
3
)
E184
-
E184
.
(
2013
)
.
Correction for Kirkby et al., Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system
.
Proceedings of the National Academy of Sciences of the United States of America
vol.
110
,
(
4
)
1561
-
1561
.
Kirkby NS, Zaiss AK, Urquhart P, Jiao J, Austin PJ, Warner TD, Nicolaou A, Herschman HR et al.
(
2013
)
.
<i>Cox2</i> reporter gene expression and prostacylin mass spectrometry confirm vascular COX-1 dominance for prostacyclin production
.
FASEB JOURNAL
.
vol.
27
,
Kirkhy NS, Wright WR, Warner TD, Paul-Clark MJ, Mitchell JA
(
2013
)
.
COX-2 and Cardiovascular Risk; Identification of New COX-2 Targets and Pathways Outside the Vessel Wall
.
CIRCULATION
.
vol.
128
,
Willeit P, Zampetaki A, Dudek K, Kaudewitz D, King A, Kirkby NS, Crosby-Nwaobi R, Prokopi M et al.
(
2013
)
.
Circulating MicroRNAs as Novel Biomarkers for Platelet Activation
.
CIRCULATION RESEARCH
vol.
112
,
(
4
)
595
-
+
.
Floyd CN, Warner TD, Ferro A
(
2013
)
.
Comparison of the optimul assay with light transmission aggregometry for the detection of aspirin resistance in patients with stable coronary artery disease
.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
.
vol.
11
,
643
-
643
.
Hoefer T, Warner TD
(
2013
)
.
DURING ANTI-PLATELET THERAPY PLATELET TURNOVER MAY LEAD TO THE EMERGENCE OF A MINORITY OF UNINHIBITED PLATELETS SUFFICIENT TO INITIATE AND DRIVE PLATELET AGGREGATE FORMATION
.
HEART
.
vol.
99
,
Ahmetaj-Shala B, Kirkby NS, Al-yamani M, Warner TD, Leiper J, Mitchell JA
(
2013
)
.
Evidence That Links Cyclo-oxygenase-2 Inhibition With Increased Asymmetric Dimethylarginine: Novel Explanation of Cardiovascular Side Effects Associated With Anti-inflammatory Drugs
.
CIRCULATION
.
vol.
128
,
Lordkipanidze M, Chan MV, Lowe GC, Dawood BB, Warner TD, Watson SP
(
2013
)
.
Head-to-head comparison of the optimul assay (96-well plate aggregometry) with gold standard light transmission aggregometry for detection of acquired and inherited platelet defects
.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
.
vol.
11
,
43
-
44
.
Bjorkman J-A, Zachrisson H, Forsberg G-B, von Bahr H, Hansson GI, Warner TD, Nylander S
(
2013
)
.
High-dose aspirin in dogs increases vascular resistance with limited additional anti-platelet effect when combined with potent P2Y<sub>12</sub> inhibition
.
THROMBOSIS RESEARCH
vol.
131
,
(
4
)
313
-
319
.
Bianca RDDV, Mitidieri E, Di Minno MND, Kirkby NS, Warner TD, Di Minno G, Cirino G, Sorrentino R
(
2013
)
.
Hydrogen sulphide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
vol.
110
,
(
39
)
15812
-
15817
.
Kaudewitz D, Lee R, Willeit P, Zampetaki A, Morton AC, Warner TD, Storey RF, Channon K et al.
(
2013
)
.
Impact of Medication on Quantification of Plasma MicroRNAs in Patients With Cardiovascular Disease
.
CIRCULATION
.
vol.
128
,
Kirkby NS, Zaiss AK, Urquhart P, Jiao J, Austin PJ, Al-Yamani M, Lundberg MH, MacKenzie LS et al.
(
2013
)
.
LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene expression pattern reveals non-vascular sites of COX-2 expression
.
PLoS One
vol.
8
,
(
7
)
Lundberg MH, Kirkby NS, Mitchell JA, Warner TD
(
2013
)
.
P2Y12 INHIBITION GREATLY POTENTIATES THE ANTI-PLATELET EFFECTS OF PROSTACYCLIN AND NITRIC OXIDE
.
HEART
.
vol.
99
,
A137
-
U630
.
Rauzi F, Kirkby NS, Edin M, Mitchell JA, Zeldin D, Warner TD
(
2013
)
.
PLATELET COX-1 SUPPORTS THE PRODUCTION OF BOTH PROSTANOIDS AND HETES
.
HEART
.
vol.
99
,
A114
-
A114
.
Bianca RDEDV, Mitidieri E, Di Minno MND, Kirkby NS, Warner TD, Di Minno G, Cirino G, Sorrentino R
(
2013
)
.
The hydrogen sulfide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia
.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
.
vol.
31
,
S24
-
S25
.
Matsumoto T, Mitchell JA, Schmidt HHHW, Kohlhaas KL, Warner TD, Förstermann U, Murad F
(
2012
)
.
Nitric oxide synthase in ferret brain: localization and characterization
.
British Journal of Pharmacology
vol.
107
,
(
3
)
849
-
852
.
Desai KM, Warner TD, Vane JR
(
2012
)
.
5‐HT3 receptors do not mediate vagally‐induced relaxation or contraction of the isolated stomach of the guinea‐pig
.
British Journal of Pharmacology
vol.
111
,
(
1
)
346
-
350
.
Mitchell JA, de Nucci G, Warner TD, Vane JR
(
2012
)
.
Alkaline buffers release EDRF from bovine cultured aortic endothelial cells
.
British Journal of Pharmacology
vol.
103
,
(
2
)
1295
-
1302
.
Battistini B, Warner TD, Fournier A, Vane JR
(
2012
)
.
Characterization of ETB receptors mediating contractions induced by endothelin‐1 or IRL 1620 in guinea‐pig isolated airways: effects of BQ‐123, FR139317 or PD 145065
.
British Journal of Pharmacology
vol.
111
,
(
4
)
1009
-
1016
.
Battistini B, O'Donnell LJD, Warner TD, Fournier A, Farthing MJG, Vane JR
(
2012
)
.
Characterization of endothelin (ET) receptors in the isolated gall bladder of the guinea‐pig: evidence for an additional ET receptor subtype
.
British Journal of Pharmacology
vol.
112
,
(
4
)
1244
-
1250
.
Warner TD, Allcock GH, Mickley EJ, Vane JR
(
2012
)
.
Characterization of endothelin receptors mediating the effects of the endothelin/sarafotoxin peptides on autonomic neurotransmission in the rat vas deferens and guinea‐pig ileum
.
British Journal of Pharmacology
vol.
110
,
(
2
)
783
-
789
.
D'Orléans‐Juste P, Claing A, Warner TD, Yano M, Télémaque S
(
2012
)
.
Characterization of receptors for endothelins in the perfused arterial and venous mesenteric vasculatures of the rat
.
British Journal of Pharmacology
vol.
110
,
(
2
)
687
-
692
.
Berthiaume N, Claing A, Regoli D, Warner TD, D'Orléans‐Juste P
(
2012
)
.
Characterization of receptors for kinins and neurokinins in the arterial and venous mesenteric vasculatures of the guinea‐pig
.
British Journal of Pharmacology
vol.
115
,
(
7
)
1319
-
1325
.
Bryant CE, Allcock GH, Warner TD
(
2012
)
.
Comparison of effects of chronic and acute administration of NG‐nitro‐L‐arginine methyl ester to the rat on inhibition of nitric oxide‐mediated responses
.
British Journal of Pharmacology
vol.
114
,
(
8
)
1673
-
1679
.
Warner TD, de Nucci G, Vane JR
(
2012
)
.
Comparison of the survival of endothelium‐derived relaxing factor and nitric oxide within the isolated perfused mesenteric arterial bed of the rat
.
British Journal of Pharmacology
vol.
97
,
(
3
)
777
-
782
.
Battistini B, Woods M, O'Donnell LJD, Warner TD, Corder R, Fournier A, Farthing MJG, Vane JR
(
2012
)
.
Contractile activity of endothelin precursors in the isolated gallbladder of the guinea‐pig: presence of an endothelin‐converting enzyme
.
British Journal of Pharmacology
vol.
114
,
(
7
)
1383
-
1390
.
Warner TD, Willis D, Moore AR, Vane JR, Klemm P
(
2012
)
.
Coronary vasoconstriction in vitro in the hearts of polyarthritic rats: effectiveness of in vivo treatment with the endothelin receptor antagonist SB 209670
.
British Journal of Pharmacology
vol.
114
,
(
7
)
1327
-
1328
.
Swierkosz TA, Mitchell JA, Warner TD, Botting RM, Vane JR
(
2012
)
.
Co‐induction of nitric oxide synthase and cyclo‐oxygenase: interactions between nitric oxide and prostanoids
.
British Journal of Pharmacology
vol.
114
,
(
7
)
1335
-
1342
.
Mitchell JA, DE Nucci G, Warner TD, Vane JR
(
2012
)
.
Different patterns of release of endothelium‐derived relaxing factor and prostacyclin
.
British Journal of Pharmacology
vol.
105
,
(
2
)
485
-
489
.
de Nucci G, Warner T, Vane JR
(
2012
)
.
Effect of Captopril on the bradykinin‐induced release of prostacyclin from guinea‐pig lungs and bovine aortic endothelial cells
.
British Journal of Pharmacology
vol.
95
,
(
3
)
783
-
788
.
D'Amico M, Dashwood MR, Warner TD
(
2012
)
.
Endothelin‐1 and the periaqueductal gray area of the rat: an autoradiographic and functional pharmacological study
.
British Journal of Pharmacology
vol.
118
,
(
1
)
21
-
26
.
Wellings RP, Corder R, Warner TD, Cristol J, Thiemermann C, Vane JR
(
2012
)
.
Evidence from receptor antagonists of an important role for ETB receptor‐mediated vasoconstrictor effects of endothelin‐1 in the rat kidney
.
British Journal of Pharmacology
vol.
111
,
(
2
)
515
-
520
.
Warner TD, Schmidt HHHW, Kuk J, Mitchell JA, Murad F
(
2012
)
.
Human brain contains a metalloprotease that converts big endothelin‐1 to endothelin‐1 and is inhibited by phosphoramidon and EDTA
.
British Journal of Pharmacology
vol.
106
,
(
3
)
505
-
506
.
Mitchell JA, Kohlhaas KL, Sorrentino R, Warner TD, Murad F, Vane JR
(
2012
)
.
Induction by endotoxin of nitric oxide synthase in the rat mesentery: lack of effect on action of vasoconstrictors
.
British Journal of Pharmacology
vol.
109
,
(
1
)
265
-
270
.
D'Amico M, Warner TD
(
2012
)
.
Involvement of endothelin in the pressor response following injection of NMDA to the periaqueductal gray area of rats
.
British Journal of Pharmacology
vol.
116
,
(
7
)
2787
-
2789
.
Cristol J, Warner TD, Thiemermann C, Vane JR
(
2012
)
.
Mediation via different receptors of the vasoconstrictor effects of endothelins and sarafotoxins in the systemic circulation and renal vasculature of the anaesthetized rat
.
British Journal of Pharmacology
vol.
108
,
(
3
)
776
-
779
.
Desai KM, Warner TD, Bishop AE, Polak JM, Vane JR
(
2012
)
.
Nitric oxide, and not vasoactive intestinal peptide, as the main neurotransmitter of vagally induced relaxation of the guinea pig stomach
.
British Journal of Pharmacology
vol.
113
,
(
4
)
1197
-
1202
.
Pérez‐Vizcaíno F, Cooper AC, Corder R, Fournier A, Warner TD
(
2012
)
.
Rapid degradation of endothelin‐1 by an enzyme released by the rat isolated perfused mesentery
.
British Journal of Pharmacology
vol.
114
,
(
4
)
867
-
871
.
Warner TD, Budzik GP, Matsumoto T, Mitchell JA, Förstermann U, Murad F
(
2012
)
.
Regional differences in endothelin converting enzyme activity in rat brain: inhibition by phosphoramidon and EDTA
.
British Journal of Pharmacology
vol.
106
,
(
4
)
948
-
952
.
Warner TD, Allcock GH, Vane JR
(
2012
)
.
Reversal of established responses to endothelin‐1 in vivo and in vitro by the endothelin receptor antagonists, BQ‐123 and PD 145065
.
British Journal of Pharmacology
vol.
112
,
(
1
)
207
-
213
.
Allcock GH, Warner TD, Vane JR
(
2012
)
.
Roles of endothelin receptors in the regional and systemic vascular responses to ET‐1 in the anaesthetized ganglion‐blocked rat: use of selective antagonists
.
British Journal of Pharmacology
vol.
116
,
(
5
)
2482
-
2486
.
Warner TD
(
2012
)
.
Simultaneous perfusion of rat isolated superior mesenteric arterial and venous beds: comparison of their vasoconstrictor and vasodilator responses to agonists
.
British Journal of Pharmacology
vol.
99
,
(
2
)
427
-
433
.
Hohlfeld T, Klemm P, Thiemermann C, Warner TD, Schrör K, Vane JR
(
2012
)
.
The contribution of tumour necrosis factor‐α and endothelin‐1 to the increase of coronary resistance in hearts from rats treated with endotoxin
.
British Journal of Pharmacology
vol.
116
,
(
8
)
3309
-
3315
.
Korbut R, Warner TD, Gryglewski RJ, Vane JR
(
2012
)
.
The effect of nitric oxide synthase inhibition on the plasma fibrinolytic system in septic shock in rats
.
British Journal of Pharmacology
vol.
112
,
(
1
)
289
-
291
.
Warner TD, Allcock GH, Corder R, Vane JR
(
2012
)
.
Use of the endothelin antagonists BQ‐123 and PD 142893 to reveal three endothelin receptors mediating smooth muscle contraction and the release of EDRF
.
British Journal of Pharmacology
vol.
110
,
(
2
)
777
-
782
.
Warner TD, Paul-Clark M, Mitchell JA
(
2012
)
.
Smoking, atherothrombosis and clopidogrel
.
Heart
vol.
98
,
(
13
)
963
-
964
.
Warner TD, Mitchell JA, Kirkby NS
(
2012
)
.
Short thromboelastography and the identification of high platelet reactivity while on and off therapy
.
Heart
vol.
98
,
(
9
)
679
-
680
.
Swales KE, Moore R, Truss NJ, Tucker A, Warner TD, Negishi M, Bishop-Bailey D
(
2012
)
.
Pregnane X receptor regulates drug metabolism and transport in the vasculature and protects from oxidative stress
.
Cardiovasc Res
vol.
93
,
(
4
)
674
-
681
.
Kirkby NS, Lundberg MH, Harrington LS, Leadbeater PDM, Milne GL, Potter CMF, Al-Yamani M, Adeyemi O et al.
(
2012
)
.
Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
vol.
109
,
(
43
)
17597
-
17602
.
Andersson T, Morrison D, Nagy P, Pisupati J, Schettler J, Warner TD
(
2012
)
.
Evaluation of the Pharmacodynamics of Acetylsalicylic Acid 81 mg With or Without Esomeprazole 20 mg in Healthy Volunteers
.
AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS
vol.
12
,
(
4
)
217
-
224
.
Mitidieri E, Bianca RDDV, Kirkby N, Warner TD, Cirino G, Sorrentino R
(
2012
)
.
L-Cysteine/H<sub>2</sub>S pathway involvement in human platelet aggregation
.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
.
vol.
27
,
S31
-
S32
.
Chan MV, Warner TD
(
2012
)
.
Standardised optical multichannel (optimul) platelet aggregometry using high-speed shaking and fixed time point readings
.
Platelets
vol.
23
,
(
5
)
404
-
408
.
Mcloughlin TF, Chan MV, Warner TD, Hart DP
(
2012
)
.
Validation of a novel, high-throughput platelet aggregation technique
.
HAEMOPHILIA
.
vol.
18
,
18
-
19
.
Truss NJ, Warner TD
(
2011
)
.
Gasotransmitters and platelets
.
Pharmacol Ther
vol.
132
,
(
2
)
196
-
203
.
Warner TD, Nylander S, Whatling C
(
2011
)
.
Anti-platelet therapy: cyclo-oxygenase inhibition and the use of aspirin with particular regard to dual anti-platelet therapy
.
Br J Clin Pharmacol
vol.
72
,
(
4
)
619
-
633
.
Kirkby NS, Leadbeater PDM, Chan MV, Nylander S, Mitchell JA, Warner TD
(
2011
)
.
Antiplatelet effects of aspirin vary with level of P2Y₁₂ receptor blockade supplied by either ticagrelor or prasugrel
.
J Thromb Haemost
vol.
9
,
(
10
)
2103
-
2105
.
Leadbeater PDM, Kirkby NS, Thomas S, Dhanji A-R, Tucker AT, Milne GL, Mitchell JA, Warner TD
(
2011
)
.
Aspirin has little additional anti-platelet effect in healthy volunteers receiving prasugrel
.
J Thromb Haemost
vol.
9
,
(
10
)
2050
-
2056
.
Sambu N, Dent H, Englyst N, Warner TD, Leadbeater P, Roderick P, Gray H, Simpson I et al.
(
2011
)
.
Effect of clopidogrel withdrawal on platelet reactivity and vascular inflammatory biomarkers 1 year after drug-eluting stent implantation: results of the prospective, single-centre CESSATION study
.
HEART
vol.
97
,
(
20
)
1661
-
1667
.
Kirkby NS, Harrington LS, Lundberg MH, Hoefer T, Warner TD, Mitchell JA
(
2011
)
.
CONTRIBUTION OF COX1 AND COX2 TO PROSTACYCLIN RELEASE BY HEALTHY MOUSE TISSUES
.
INFLAMMATION RESEARCH
.
vol.
60
,
116
-
117
.
Wright WR, Kirkby NS, Harrington LS, Lundberg MH, Paul-Clark MJ, Warner TD, Mitchell JA
(
2011
)
.
ROLE OF COX-1 AND COX-2 IN THE RELEASE OF PROSTANOIDS IN MURINE LUNG AND ISOLATED LUNG FIBROBLASTS
.
INFLAMMATION RESEARCH
.
vol.
60
,
232
-
232
.
Sambu N, Dent H, Warner T, Englyst N, Leadbeater P, Hobson A, Calver A, Corbett S et al.
(
2011
)
.
WHAT HAPPENS TO PLATELET FUNCTION AND VASCULAR INFLAMMATION WHEN CLOPIDOGREL IS WITHDRAWN? INSIGHTS USING SHORT THROMBELASTOGRAPHY
.
HEART
.
vol.
97
,
A16
-
A16
.
Armstrong PCJ, Leadbeater PD, Chan MV, Kirkby NS, Jakubowski JA, Mitchell JA, Warner TD
(
2011
)
.
In the presence of strong P2Y12 receptor blockade, aspirin provides little additional inhibition of platelet aggregation
.
J Thromb Haemost
vol.
9
,
(
3
)
552
-
561
.
Sambu N, Warner T, Curzen N
(
2011
)
.
Clopidogrel withdrawal: Is there a "rebound" phenomenon?
.
THROMB HAEMOSTASIS
vol.
105
,
(
2
)
211
-
220
.
Potter CMF, Lundberg MH, Harrington LS, Warboys CM, Warner TD, Berson RE, Moshkov AV, Gorelik J et al.
(
2011
)
.
Role of Shear Stress in Endothelial Cell Morphology and Expression of Cyclooxygenase Isoforms
.
ARTERIOSCL THROM VAS
vol.
31
,
(
2
)
384
-
U314
.
Warner TD
(
2011
)
.
What is the best dose of aspirin in association with P2Y12 antagonists? reply
.
HEART
vol.
97
,
(
3
)
264
-
264
.
Huang RY, Li MY, Hsin MKY, Underwood MJ, Ma LT, Mok TSK, Warner TD, Chen GG
(
2011
)
.
4-Methylnitrosamino-1-3-pyridyl-1-butanone (NNK) promotes lung cancer cell survival by stimulating thromboxane A(2) and its receptor
.
ONCOGENE
vol.
30
,
(
1
)
106
-
116
.
Kirkby NS, Leadbeater PDM, Chan MV, Nylander S, Mitchell JA, Warner TD
(
2011
)
.
Aspirin augments the anti-platelet effects of partial but not complete P2Y<sub>12</sub> receptor blockade by ticagrelor
.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
.
vol.
9
,
780
-
780
.
Bystrom J, Wray JA, Sugden MC, Holness MJ, Swales KE, Warner TD, Edin ML, Zeldin DC et al.
(
2011
)
.
Endogenous epoxygenases are modulators of monocyte/macrophage activity
.
PLoS One
vol.
6
,
(
10
)
Chan MV, Armstrong PCJ, Papalia F, Kirkby NS, Warner TD
(
2011
)
.
Optical multichannel (optimul) platelet aggregometry in 96-well plates as an additional method of platelet reactivity testing
.
Platelets
vol.
22
,
(
7
)
485
-
494
.
Sambu N, Dent H, Warner T, Englyst N, Leadbeater P, Hobson A, Calver A, Corbett S et al.
(
2011
)
.
Stopping Clopidogrel 1 year After Drug-Eluting Stent (DES) Implantation: Is It Safe?
.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
.
vol.
58
,
B41
-
B41
.
Kirkby NS, Singhal R, Mitchell JA, Warner TD
(
2011
)
.
Synergistic inhibition of platelet aggregation by nitric oxide and prostacyclin is potentiated by P2Y<sub>12</sub> blockade
.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
.
vol.
9
,
780
-
781
.
Leadbeater PDM, Mitchell JA, Warner TD
(
2011
)
.
The effect of stir-speed and time on TP-receptor induced platelet aggregation in the presence of aspirin and P2Y<sub>12</sub> receptor blockade
.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
.
vol.
9
,
779
-
780
.
Leadbeater PDM, Farndale RW, Mitchell JA, Warner TD
(
2011
)
.
The effect of stir-speed on GPVI-dependent platelet aggregation
.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
.
vol.
9
,
528
-
529
.
Leadbeater PDM, Mitchell JA, Warner TD
(
2011
)
.
The effect of time on platelet aggregation assessed by light transmission
.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
.
vol.
9
,
779
-
779
.
Armstrong PC, Kirkby NS, Zain ZN, Emerson M, Mitchell JA, Warner TD
(
2011
)
.
Thrombosis is reduced by inhibition of COX-1, but unaffected by inhibition of COX-2, in an acute model of platelet activation in the mouse
.
PLoS One
vol.
6
,
(
5
)
Kolstoe SE, Mangione PP, Bellotti V, Taylor GW, Tennent GA, Deroo S, Morrison AJ, Cobb AJA et al.
(
2010
)
.
Trapping of palindromic ligands within native transthyretin prevents amyloid formation
.
P NATL ACAD SCI USA
vol.
107
,
(
47
)
20483
-
20488
.
Warner TD, Armstrong PCJ, Curzen NP, Mitchell JA
(
2010
)
.
Dual antiplatelet therapy in cardiovascular disease: does aspirin increase clinical risk in the presence of potent P2Y12 receptor antagonists?
.
Heart
vol.
96
,
(
21
)
1693
-
1694
.
MOYNIHAN HA, ROBERTS SM, WELDON H, ALLCOCK GH, AENGGARD EE, WARNER TD
(
2010
)
.
ChemInform Abstract: Synthesis and Biological Activity of the Novel Nitric Oxide Synthase Inhibitor Nω′‐Hydroxy‐Nω‐methyl‐L‐arginine
.
ChemInform
vol.
25
,
(
32
)
no
-
no
.
Moreno L, McMaster SK, Gatheral T, Bailey LK, Harrington LS, Cartwright N, Armstrong PCJ, Warner TD et al.
(
2010
)
.
Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells: comparison with Toll-like receptor 4 responses in macrophages
.
BRIT J PHARMACOL
vol.
160
,
(
8
)
1997
-
2007
.
Leadbeater P, Pathan N, Paul-Clark M, Warner T, Mitchell J
(
2010
)
.
Serum lipoteichoic acid in paediatric patients undergoing surgery with cardiopulmonary bypass
.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
.
vol.
70
,
293
-
293
.
Shinhmar S, Truss N, Armstrong P, Vojnovic I, Warner T
(
2010
)
.
Use of a 96-well plate method for the determination of the anti-platelet effectiveness of a novel NO releasing aspirin molecule
.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
.
vol.
70
,
303
-
303
.
Armstrong PCJ, Dhanji A-RA, Tucker AT, Mitchell JA, Warner TD
(
2010
)
.
Reduction of platelet thromboxane A2 production ex vivo and in vivo by clopidogrel therapy
.
J Thromb Haemost
vol.
8
,
(
3
)
613
-
615
.
Warner TD, Bjorkman J-A, Zachrisson H, Nylander S
(
2010
)
.
Acetylsalicylic Acid (ASA) Adds Limited Additional Antiplatelet Effect When Given in Addition to High-Level P2y<sub>12</sub> Receptor Inhibition and Can Increase Peripheral Vascular Resistance
.
CIRCULATION
.
vol.
122
,
Vessillier S, Duchene J, Vojnovic I, Cipollone F, Mezzetti A, White S, Ahluwalia A, Bishop-Bailey D et al.
(
2009
)
.
THERAPEUTIC TARGETTING OF ATHEROSCLEROTIC PLAQUES WITH LATENT INTERLEUKIN-4
.
HEART
.
vol.
95
,
Armstrong PCJ, Dhanji AA, Tucker AT, Mitchell JA, Warner TD
(
2009
)
.
URINARY 11-DEHYDRO-THROMBOXANE B2 AS A MARKER OF THE ANTI-PLATELET EFFECTS OF CLOPIDOGREL OR ASPIRIN THERAPY IN HEALTHY MALE VOLUNTEERS
.
HEART
.
vol.
95
,
Truss NJ, Armstrong PCJ, Liverani E, Vojnovic I, Warner TD
(
2009
)
.
Heparin but not citrate anticoagulation of blood preserves platelet function for prolonged periods
.
J Thromb Haemost
vol.
7
,
(
11
)
1897
-
1905
.
Ali FY, Hall MG, Desvergne B, Warner TD, Mitchell JA
(
2009
)
.
PPARbeta/delta agonists modulate platelet function via a mechanism involving PPAR receptors and specific association/repression of PKCalpha--brief report
.
Arterioscler Thromb Vasc Biol
vol.
29
,
(
11
)
1871
-
1873
.
Leung KC, Hsin MKY, Chan JSY, Yip JHY, Li MY, Leung BCS, Mok TSK, Warner TD et al.
(
2009
)
.
Inhibition of thromboxane synthase induces lung cancer cell death via increasing the nuclear p27
.
EXP CELL RES
vol.
315
,
(
17
)
2974
-
2981
.
Wray JA, Sugden MC, Zeldin DC, Greenwood GK, Samsuddin S, Miller-Degraff L, Bradbury JA, Holness MJ et al.
(
2009
)
.
The epoxygenases CYP2J2 activates the nuclear receptor PPARalpha in vitro and in vivo
.
PLoS One
vol.
4
,
(
10
)
Armstrong PCJ, Dhanji A-R, Truss NJ, Zain ZNM, Tucker AT, Mitchell JA, Warner TD
(
2009
)
.
Utility of 96-well plate aggregometry and measurement of thrombi adhesion to determine aspirin and clopidogrel effectiveness
.
Thromb Haemost
vol.
102
,
(
4
)
772
-
778
.
Morris T, Stables M, Hobbs A, de Souza P, Colville-Nash P, Warner T, Newson J, Bellingan G et al.
(
2009
)
.
Effects of Low-Dose Aspirin on Acute Inflammatory Responses in Humans
.
J IMMUNOL
vol.
183
,
(
3
)
2089
-
2096
.
Swierkosz TA, Warner TD, Vane JR
(
2009
)
.
NG-Hydroxy-L-Arginine Releases from Endothelial Cells Nitric Oxide which Increases cGMP in RFL-6 Fibroblasts
.
Endothelium
vol.
3
,
(
2
)
121
-
129
.
Chen G, Wang SH, Warner TD
(
2009
)
.
Regulation of iNOS mRNA levels in endothelial cells by glutathione, a double-edged sword
.
Free Radical Research
vol.
32
,
(
3
)
223
-
234
.
Truss NJ, Beavis J, Maccallum PK, Harrison P, Warner TD
(
2009
)
.
Rapid and accurate method for the von Willebrand factor ristocetin cofactor assay using 96-well microtiter plates
.
J THROMB HAEMOST
vol.
7
,
(
7
)
1226
-
1228
.
Ali FY, Armstrong PCJ, Dhanji A-RA, Tucker AT, Paul-Clark MJ, Mitchell JA, Warner TD
(
2009
)
.
Antiplatelet actions of statins and fibrates are mediated by PPARs
.
Arterioscler Thromb Vasc Biol
vol.
29
,
(
5
)
706
-
711
.
Bishop‐Bailey D, Larkin SW, Warner TD, Chen G, Mitchell JA
(
2009
)
.
Characterization of the induction of nitric oxide synthase and cyclo‐oxygenase in rat aorta in organ culture
.
British Journal of Pharmacology
vol.
121
,
(
1
)
125
-
133
.
Hamilton LC, Warner TD
(
2009
)
.
Interactions between inducible isoforms of nitric oxide synthase and cyclo‐oxygenase in vivo: investigations using the selective inhibitors, 1400W and celecoxib
.
British Journal of Pharmacology
vol.
125
,
(
2
)
335
-
340
.
Mitchell JA, Warner TD
(
2009
)
.
Cyclo‐oxygenase‐2: pharmacology, physiology, biochemistry and relevance to NSAID therapy
.
British Journal of Pharmacology
vol.
128
,
(
6
)
1121
-
1132
.
Hamilton LC, Vojnovic I, Warner TD
(
2009
)
.
A771726, the active metabolite of leflunomide, directly inhibits the activity of cyclo‐oxygenase‐2 in vitro and in vivo in a substrate‐sensitive manner
.
British Journal of Pharmacology
vol.
127
,
(
7
)
1589
-
1596
.
Bishop‐Bailey D, Hla T, Warner TD
(
2009
)
.
Bisphenol A diglycidyl ether (BADGE) is a PPARγ agonist in an ECV304 cell line
.
British Journal of Pharmacology
vol.
131
,
(
4
)
651
-
654
.
Giuliano F, Warner TD
(
2009
)
.
Ex vivo assay to determine the cyclooxygenase selectivity of non‐steroidal anti‐inflammatory drugs
.
British Journal of Pharmacology
vol.
126
,
(
8
)
1824
-
1830
.
Armstrong PCJ, Dhanji AA, Truss NJ, Zain ZNM, Tucker AT, Mitchell JA, Warner TD
(
2009
)
.
Determination and differentiation of aspirin and clopidogrel effectiveness by 96-well plate aggregometry and measurement of thrombi adhesion
.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
.
vol.
7
,
572
-
573
.
Dhanji AA, Ali FY, Harrington LS, Shipolini A, Mitchell JA, Warner TD
(
2009
)
.
Making anti-thrombotic bypass vessels from selected populations of vascular smooth muscle cells
.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
.
vol.
7
,
74
-
74
.
Truss NJ, Armstrong PCJ, Shinhmar SK, Warner TD
(
2009
)
.
Nitric oxide inhibits platelet aggregation independantly from formation of thromboxane A2
.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
.
vol.
7
,
933
-
933
.
Truss NJ, Ali FY, Armstrong PCJ, Warner TD
(
2009
)
.
The effect of hydrogen sulphide on platelet action
.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
.
vol.
7
,
933
-
933
.
Armstrong PCJ, Dhanji AA, Tucker AT, Mitchell JA, Warner TD
(
2009
)
.
Urinary 11-dehydro-thromboxane B2 as a marker of the anti-platelet effects of clopidogrel or aspirin therapy in healthy male volunteers
.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
.
vol.
7
,
573
-
573
.
Armstrong PCJ, Truss NJ, Ali FY, Dhanji AA, Vojnovic I, Zain ZNM, Bishop-Bailey D, Paul-Clark MJ et al.
(
2008
)
.
Aspirin and the in vitro linear relationship between thromboxane A2-mediated platelet aggregation and platelet production of thromboxane A2
.
J Thromb Haemost
vol.
6
,
(
11
)
1933
-
1943
.
Harrington LS, Lucas R, McMaster SK, Moreno L, Scadding G, Warner TD, Mitchell JA
(
2008
)
.
COX-1, and not COX-2 activity, regulates airway function: relevance to aspirin-sensitive asthma
.
FASEB J
vol.
22
,
(
11
)
4005
-
4010
.
Ali FY, Warner TD, Mitchell JA
(
2008
)
.
Comparison of responses in IP and PPAR beta deleted murine platelets
.
HEART
.
vol.
94
,
Zain ZNM, Armstrong PCJ, Pearson NJ, Mitchell JA, Warner TD
(
2008
)
.
Evaluation of aspirin inhibition of platelet aggregation induced by combination of collagen and adrenaline in a 96-well plate format
.
HEART
.
vol.
94
,
Dhanji AA, Truss NJ, Bishop-Bailey D, Shipolini A, Mitchell JA, Warner TD
(
2008
)
.
Generation of clonal populations of prostaglandin I-2-producing rat vascular smooth muscle cells: Potential utility for production of bypass vessels
.
HEART
.
vol.
94
,
Armstrong PCJ, Zain ZNM, Truss NJ, Vojnovic I, Bishop-Bailey D, Mitchell JA, Warner TD
(
2008
)
.
Linear relationship between platelet aggregation and thromboxane A(2) production
.
HEART
.
vol.
94
,
Truss NJ, Armstrong PCJ, Zain ZN, Ali FY, Warner TD
(
2008
)
.
Platelet aggregation after storage of whole blood at 4 degrees C
.
HEART
.
vol.
94
,
Vessillier S, Duchene J, Vojnovic I, Ahluwalia A, Bishop-Bailey D, Chernajovsky Y, Warner TD
(
2008
)
.
Stabilisation of atherosclerotic plaques: The latent targeting cytokines strategy
.
HEART
.
vol.
94
,
Boesen EI, Sasser JM, Saleh MA, Potter WA, Woods M, Warner TD, Pollock JS, Pollock DM
(
2008
)
.
Interleukin-1 beta, but not interleukin-6, enhances renal and systemic endothelin production in vivo
.
AM J PHYSIOL-RENAL
vol.
295
,
(
2
)
F446
-
F453
.
Papalia F, Armstrong PCJ, Pearson NJ, Zain ZNM, Ali FY, Vojnovic I, Warner TD
(
2008
)
.
Development of a routine test of platelet reactivity
.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
.
vol.
65
,
979
-
979
.
Aboud Z, Misra S, Warner T, Miall P, Benjamin N, Hobbs A, Webb A, Ahluwalia A
(
2008
)
.
The enterosalivary bioconversion of nitrate to nitrite underlies the blood pressure (BP) lowering and anti-platelet effects of a dietary nitrate load
.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
.
vol.
65
,
999
-
999
.
Warner TD, Mitchell JA
(
2008
)
.
COX-2 selectivity alone does not define the cardiovascular risks associated with non-steroidal anti-inflammatory drugs
.
LANCET
vol.
371
,
(
9608
)
270
-
273
.
Truss NJ, Warner TD
(
2008
)
.
Gases help fuel the vascular debate
.
EXP PHYSIOL
vol.
93
,
(
1
)
139
-
140
.
Li YTY, Swales KE, Thomas GJ, Warner TD, Bishop-Bailey D
(
2007
)
.
Farnesoid x receptor ligands inhibit vascular smooth muscle cell inflammation and migration
.
Arterioscler Thromb Vasc Biol
vol.
27
,
(
12
)
2606
-
2611
.
Patel TA, Belcher E, Warner TD, Harding SE, Mitchell JA
(
2007
)
.
Identification and characterization of a dysfunctional cardiac myocyte phenotype: Role of bacteria, toll-like receptors, and endothelin
.
SHOCK
vol.
28
,
(
4
)
434
-
440
.
Piqueras L, Norlyng L, Perretti M, Li Y, Sanz MJ, Real JT, Warner T, Bishop-Bayley D
(
2007
)
.
PPARb inhibits neutrophil-endothelium interactions under flow
.
INFLAMM RES
.
vol.
56
,
S453
-
S454
.
Moraes LA, Swales KE, Wray JA, Damazo A, Gibbins JM, Warner TD, Bishop-Bailey D
(
2007
)
.
Nongenomic signaling of the retinoid X receptor through binding and inhibiting Gq in human platelets
.
Blood
vol.
109
,
(
9
)
3741
-
3744
.
Warner TD
(
2007
)
.
Endothelin Receptor Antagonists
.
Cardiovascular Therapeutics
vol.
12
,
(
2
)
105
-
122
.
Piqueras L, Reynolds AR, Hodivala-Dilke KM, Alfranca A, Redondo JM, Hatae T, Tanabe T, Warner TD et al.
(
2007
)
.
Activation of PPARbeta/delta induces endothelial cell proliferation and angiogenesis
.
Arterioscler Thromb Vasc Biol
vol.
27
,
(
1
)
63
-
69
.
Mitchell JA, Lucas R, Vojnovic I, Hasan K, Pepper JR, Warner TD
(
2006
)
.
Stronger inhibition by nonsteroid anti-inflammatory drugs of cyclooxygenase-1 in endothelial cells than platelets offers an explanation for increased risk of thrombotic events
.
FASEB J
vol.
20
,
(
14
)
2468
-
2475
.
Swales KE, Korbonits M, Carpenter R, Walsh DT, Warner TD, Bishop-Bailey D
(
2006
)
.
The farnesoid X receptor is expressed in breast cancer and regulates apoptosis and aromatase expression
.
Cancer Res
vol.
66
,
(
20
)
10120
-
10126
.
Perez-Vizcaino F, Bishop-Bailley D, Lodi F, Duarte J, Cogolludo A, Moreno L, Bosca L, Mitchell JA et al.
(
2006
)
.
The flavonoid quercetin induces apoptosis and inhibits JNK activation in intimal vascular smooth muscle cells
.
Biochem Biophys Res Commun
vol.
346
,
(
3
)
919
-
925
.
Patel TA, Mitchell JA, Warner TD, Harding SE
(
2006
)
.
Gram positive bacteria reduce viability and contraction of isolated cardiomyocytes: Role of endothelin-1
.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
.
vol.
40
,
1007
-
1007
.
Bishop-Bailey D, Mitchell JA, Warner TD
(
2006
)
.
COX-2 in cardiovascular disease
.
Arterioscler Thromb Vasc Biol
vol.
26
,
(
5
)
956
-
958
.
Chen GG, Lee TW, Yip JHY, Xu H, Lee IKY, Mok TSK, Warner TD, Yim APC
(
2006
)
.
Increased thromboxane B-2 levels are associated with lipid peroxidation and Bcl-2 expression in human lung carcinoma
.
CANCER LETT
vol.
234
,
(
2
)
193
-
198
.
Warner TD, Vojnovic I, Bishop-Bailey D, Mitchell JA
(
2006
)
.
Influence of plasma protein on the potencies of inhibitors of cyclooxygenase-1 and -2
.
FASEB J
vol.
20
,
(
3
)
542
-
544
.
Burke SG, Wainwright CL, Vojnovic I, Warner T, Watson DG, Furman BL
(
2006
)
.
The effect of NCX4016 [2-acetoxy-benzoate 2-(2-nitroxymethyl)-phenyl ester] on the consequences of ischemia and reperfusion in the streptozotocin diabetic rat
.
J PHARMACOL EXP THER
vol.
316
,
(
3
)
1107
-
1114
.
Ali FY, Davidson SJ, Moraes LA, Traves SL, Paul-Clark M, Bishop-Bailey D, Warner TD, Mitchell JA
(
2006
)
.
Role of nuclear receptor signaling in platelets: antithrombotic effects of PPAR beta
.
FASEB J
vol.
20
,
(
2
)
326
-
328
.
Ali FY, Davidson SJ, Moraes LA, Traves SL, Paul-Clark M, Bishop-Bailey D, Warner TD, Mitchell JA
(
2006
)
.
Role of nuclear receptor signaling in platelets: antithrombotic effects of PPARbeta
.
FASEB J
vol.
20
,
(
2
)
326
-
328
.
Ali FY, Egan K, FitzGerald GA, Desvergne B, Wahli W, Bishop-Bailey D, Warner TD, Mitchell JA
(
2006
)
.
Role of prostacyclin versus peroxisome proliferator-activated receptor beta receptors in prostacyclin sensing by lung fibroblasts
.
Am J Respir Cell Mol Biol
vol.
34
,
(
2
)
242
-
246
.
Mitchell JA, Warner TD
(
2006
)
.
COX isoforms in the cardiovascular system: understanding the activities of non-steroidal anti-inflammatory drugs
.
NAT REV DRUG DISCOV
vol.
5
,
(
1
)
75
-
85
.
Li MY, Lee TW, Mok TSK, Warner TD, Yim APC, Chen GG
(
2005
)
.
Activation of peroxisome proliferator-activated receptor-gamma by troglitazone (TGZ) inhibits human lung cell growth
.
J CELL BIOCHEM
vol.
96
,
(
4
)
760
-
774
.
Piqueras L, Warner TD, Bishop-Bailey D
(
2005
)
.
Expression of peroxisome proliferators-activator receptor-delta and retinoid X receptors in endothelial cells
.
HEART
.
vol.
91
,
Haque ME, Moraes LA, Warner TD, Bishop-Bailey D
(
2005
)
.
Farnesoid X receptor ligands inhibited human platelet aggregation induced by ADP
.
HEART
.
vol.
91
,
Wray JA, Williams NP, Warner TD, Bishop-Bailey D
(
2005
)
.
PPAR-alpha activation downregulates COX-2 expression in human monocytes
.
HEART
.
vol.
91
,
Moraes LA, Warner TD, Bishop-Bailey D
(
2005
)
.
Retinoid X receptor ligands inhibit human platelet aggregation induced by ADP and U46619
.
HEART
.
vol.
91
,
Jimenez R, Belcher E, Sriskandan S, Lucas R, McMaster S, Vojnovic L, Warner TD, Mitchell JA
(
2005
)
.
Role of Toll-like receptors 2 and 4 in the induction of cyclooxygenase-2 in vascular smooth muscle
.
P NATL ACAD SCI USA
vol.
102
,
(
12
)
4637
-
4642
.
Lucas R, Warner TD, Vojnovic I, Mitchell JA
(
2005
)
.
Cellular mechanisms of acetaminophen: role of cyclooxygenase
.
FASEB J
vol.
19
,
(
2
)
635
-
+
.
Zacharowski P, Breese E, Wood E, Del Soldato P, Warner T, Mitchell J
(
2005
)
.
NSAIDs increase GM-CSF release by human synoviocytes: comparison with nitric oxide-donating derivatives
.
Eur J Pharmacol
vol.
508
,
(
1-3
)
7
-
13
.
Mitchell JA, Warner TD
(
2005
)
.
Discontinuation of Vioxx
.
LANCET
vol.
365
,
(
9453
)
27
-
28
.
Warner T, Ali F, Bishop-Bailey D, Mitchell J, Moraes L
(
2005
)
.
Influences of nuclear receptors on platelet
.
JOURNAL OF VASCULAR RESEARCH
.
vol.
42
,
24
-
25
.
Rao M, Yang W, Bishop-Bailey D, Warner TD, Seifalian AM, Winslet MC
(
2004
)
.
Roles of cyclo-oxygenase 2 and prostanoids in the development of liver metastases from colorectal cancer
.
BRITISH JOURNAL OF SURGERY
.
vol.
91
,
1230
-
1230
.
Warner TD, Vojnovic I, Giuliano F, Jiménez R, Bishop-Bailey D, Mitchell JA
(
2004
)
.
Cyclooxygenases 1, 2, and 3 and the production of prostaglandin I2: investigating the activities of acetaminophen and cyclooxygenase-2-selective inhibitors in rat tissues
.
J Pharmacol Exp Ther
vol.
310
,
(
2
)
642
-
647
.
Warner TD, Mitchell JA
(
2004
)
.
Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic
.
FASEB J
vol.
18
,
(
7
)
790
-
804
.
Sasser JM, Woods M, Warner TD, Pollock DM, Pollock JS
(
2004
)
.
Role of nuclear factor-kappa B in interleukin-1 beta stimulated endothelin-1 release in inner medullary collecting duct cells
.
FASEB JOURNAL
.
vol.
18
,
A1322
-
A1322
.
Bishop-Bailey D, Walsh DT, Warner TD
(
2004
)
.
Expression and activation of the farnesoid X receptor in the vasculature
.
Proc Natl Acad Sci U S A
vol.
101
,
(
10
)
3668
-
3673
.
Trummlitz G, van Ryn J, Warner TD
(
2004
)
.
The molecular and biological basis for COX-2 selectivity
.
COX-2 Inhibitors
,
Springer Nature
Warner TD, Mitchell JA
(
2003
)
.
HIF, stretching to get control of VEGF
.
Clin Sci (Lond)
vol.
105
,
(
4
)
393
-
394
.
Bishop-Bailey D, Warner TD
(
2003
)
.
PPARgamma ligands induce prostaglandin production in vascular smooth muscle cells: indomethacin acts as a peroxisome proliferator-activated receptor-gamma antagonist
.
FASEB J
vol.
17
,
(
13
)
1925
-
1927
.
Woods M, Wood EG, Bardswell SC, Bishop-Bailey D, Barker S, Wort SJ, Mitchell JA, Warner TD
(
2003
)
.
Role for nuclear factor-kappaB and signal transducer and activator of transcription 1/interferon regulatory factor-1 in cytokine-induced endothelin-1 release in human vascular smooth muscle cells
.
Mol Pharmacol
vol.
64
,
(
4
)
923
-
931
.
Jimenez R, Warner TD, Belcher PE, Vojnovic I, Mitchell JA
(
2003
)
.
Induction of NOSII and COX activity in primary cultures of murine smooth muscle cells
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
140
,
Warner TD, Mitchell JA
(
2003
)
.
Nonsteroidal antiinflammatory drugs inhibiting prostanoid efflux: as easy as ABC?
.
Proc Natl Acad Sci U S A
vol.
100
,
(
16
)
9108
-
9110
.
Wray J, Zeldin D, Warner TD, Bishop-Bailey D
(
2003
)
.
Cytochrome P450 2J2 over-expression activates peroxisome proliferator-activated receptor-alpha
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
138
,
U85
-
U85
.
Bishop-Bailey D, Walsh DT, Warner TD
(
2003
)
.
Farnesoid X receptor (FXR) as a novel target in vascular smooth muscle cells
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
138
,
U30
-
U30
.
Walters MJ, Warner TD, Bishop-Bailey D, Mitchell JA
(
2003
)
.
The PPAR gamma ligand 15-deoxy-Delta(12,14)-prostaglandin J(2) (15D-PGJ(2)) inhibits proliferation and cytokine release from human pulmonary artery smooth muscle
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
138
,
U66
-
U66
.
Thomas MA, Bishop-Bailey D, Warner TD
(
2003
)
.
The novel CO releasing compound tricarbonyldichlororuthenium (II) dimer confers protection from free radical mediated cytotoxicity in WKY 3M-22 cell line and primary rat aortic smooth muscle cells
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
138
,
U84
-
U84
.
Thomas MA, Warner TD, Bishop-Bailey D
(
2003
)
.
The novel CO releasing compound Tricarbonyldichlororuthenium (11) dimer protects H9C2 rat cardiomyoblasts from free radical mediated cytotoxicity
.
FASEB JOURNAL
.
vol.
17
,
A618
-
A619
.
Warner TD, Vojnovic I, Hisiop A, Haworth S, Mitchell JA
(
2003
)
.
Angiotensin-II causes receptor mediated reactive nitrogen species formation in vascular endothelial cells
.
FASEB JOURNAL
.
vol.
17
,
A1057
-
A1057
.
Gitlin JM, Warner TD, Vojnovic I
(
2003
)
.
Apparent relationship between COX-1, COX-2 and prostacyclin synthase in pulmonary adaption at birth: Consequences for pulmonary hypertension
.
FASEB JOURNAL
.
vol.
17
,
A1057
-
A1057
.
Somuyiwa A, Stanford S, Gitlin J, Vojnovic I, Warner TD, Hislop A, Howarth S, Mitchell JA
(
2003
)
.
Cyclo-oxygenase-2 expression in the lung in the period of pulmonary development after birth
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
140
,
Gray PA, Warner TD, Vojnovic I, Del Soldato P, Parikh A, Scadding GK, Mitchell JA
(
2002
)
.
Effects of non-steroidal anti-inflammatory drugs on cyclo-oxygenase and lipoxygenase activity in whole blood from aspirin-sensitive asthmatics vs healthy donors
.
Br J Pharmacol
vol.
137
,
(
7
)
1031
-
1038
.
Giuliano F, Warner TD
(
2002
)
.
Origins of prostaglandin E2: involvements of cyclooxygenase (COX)-1 and COX-2 in human and rat systems
.
J Pharmacol Exp Ther
vol.
303
,
(
3
)
1001
-
1006
.
Calatayud S, Warner TD, Breese EJ, Mitchell JA
(
2002
)
.
Modulation by colony stimulating factors of human epithelial colon cancer cell apoptosis
.
CYTOKINE
vol.
20
,
(
4
)
163
-
167
.
Warner TD, Mitchell JA, Vane JR
(
2002
)
.
Cyclo-oxygenase-2 inhibitors and cardiovascular events
.
LANCET
vol.
360
,
(
9346
)
1700
-
1701
.
Wort SJ, Woods M, Warner TD, Evans TW, Mitchell JA
(
2002
)
.
Cyclooxygenase-2 acts as an endogenous brake on endothelin-1 release by human pulmonary artery smooth muscle cells: implications for pulmonary hypertension
.
Mol Pharmacol
vol.
62
,
(
5
)
1147
-
1153
.
Warner TD, Mitchell JA
(
2002
)
.
Cyclooxygenase-3 (COX-3): filling in the gaps toward a COX continuum?
.
Proc Natl Acad Sci U S A
vol.
99
,
(
21
)
13371
-
13373
.
McCartney SA, Ballinger AB, Vojnovic I, Farthing MJG, Warner TD
(
2002
)
.
Endothelin in human inflammatory bowel disease: comparison to rat trinitrobenzenesulphonic acid-induced colitis
.
Life Sci
vol.
71
,
(
16
)
1893
-
1904
.
Bishop-Bailey D, Hla T, Warner TD
(
2002
)
.
Intimal smooth muscle cells as a target for peroxisome proliferator-activated receptor-gamma ligand therapy
.
Circ Res
vol.
91
,
(
3
)
210
-
217
.
Sims EC, Rothman MT, Warner TD, Powell MEB
(
2002
)
.
Coronary artery brachytherapy
.
CLIN ONCOL-UK
vol.
14
,
(
4
)
313
-
326
.
McCartney SA, Greaves RRSH, Warner TD, O'Donnell LJD, Domizio P, Farthing MJG
(
2002
)
.
Endothelin content, expression, and receptor type in normal and diseased human gallbladder
.
Dig Dis Sci
vol.
47
,
(
8
)
1786
-
1792
.
Burke SG, Furman BL, Wainwright CL, Del Soldato P, Vojnovic I, Warner T
(
2002
)
.
The effect of no-aspirin on arrhythmias & infarct size in hearts isolated from the SHR
.
J MOL CELL CARDIOL
vol.
34
,
(
6
)
A14
-
A14
.
Calatayud S, Warner TD, Mitchell JA
(
2002
)
.
Modulation of colony stimulating factor release and apoptosis in human colon cancer cells by anticancer drugs
.
BRIT J CANCER
vol.
86
,
(
8
)
1316
-
1321
.
Calatayud S, Mitchell JA, Perretti M, Giuliano F, Warner TD
(
2002
)
.
Effects of cyclooxygenase-1/cyclooxygenase-2 inhibition on leukocyte/endothelial cell interactions in the rat mesentery
.
EUR J PHARMACOL
vol.
440
,
(
1
)
71
-
77
.
Woods M, Wood EG, Mitchell JA, Bishop-Bailey D, Warner TD
(
2002
)
.
Antisense to STAT1/IRF-1 and NF-kappa B inhibits cytokine-stimulated ET-1 release from human vascular smooth muscle cells
.
BRIT J PHARMACOL
.
vol.
135
,
Thomas MA, Bishop-Bailey D, Warner TD
(
2002
)
.
Heme oxygenase induction is associated with protection from SIN-1 cytotoxicity in WKY 3M-22 rat aortic smooth muscle cells
.
BRIT J PHARMACOL
.
vol.
135
,
Giuliano F, Vojnovic L, Warner TD
(
2002
)
.
Prostacyclin production from intact pat blood vessels is via the activity of cyclooxygenase-1 as defined by naproxen, paracetamol, rofecoxib and SC560
.
BRIT J PHARMACOL
.
vol.
135
,
Burke SG, Furman BL, Wainwright CL, Del Soldato P, Vojnovic I, Warner T
(
2002
)
.
The effect of NO-aspirin on arrhythmias and infarct size in isolated spontaneously hypertensive rat hearts
.
BRIT J PHARMACOL
.
vol.
135
,
Warner TD
(
1999
)
.
RELATIONSHIPS BETWEEN THE ENDOTHELIN AND NITRIC OXIDE PATHWAYS
.
Clinical and Experimental Pharmacology and Physiology
.
vol.
26
,
247
-
252
.
Zacharowski K, Rensing H, Frank S, Warner TD
(
2002
)
.
Doses of bacterial wall fragment of S-aureus that induce delayed preconditioning do not induce heme oxygenase-1 and inducible nitric oxide synthase
.
BRIT J PHARMACOL
.
vol.
135
,
Gray PA, Vojnovic I, Del Soldato P, Mitchell JA, Warner TD
(
2002
)
.
Effects of plasma proteins and blood elements on the potencies of flurbiprofen and NO-flurbiprofen as inhibitors of thromboxane A(2) formation by human platelets
.
BRIT J PHARMACOL
.
vol.
135
,
Kvirkvelia N, Vojnovic I, Warner TD, Athie-Morales V, Free P, Rayment N, Chain BM, Rademacher TW et al.
(
2002
)
.
Placentally derived prostaglandin E-2 acts via the EP4 receptor to inhibit IL-2-dependent proliferation of CTLL-2 T cells
.
CLIN EXP IMMUNOL
vol.
127
,
(
2
)
263
-
269
.
Bishop-Bailey D, Calatayud S, Warner TD, Hla T, Mitchell JA
(
2002
)
.
Prostaglandins and the regulation of tumor growth
.
J Environ Pathol Toxicol Oncol
vol.
21
,
(
2
)
93
-
101
.
Warner T
(
2002
)
.
Valdecoxib - A viewpoint by Tim Warner
.
DRUGS
vol.
62
,
(
14
)
2072
-
2073
.
Mccartney, Mitchell, Fairclough, Farthing, Warner
(
2001
)
.
Selective COX‐2 inhibitors and human inflammatory bowel disease
.
Alimentary Pharmacology & Therapeutics
vol.
13
,
(
8
)
1115
-
1117
.
Giuliano F, Mitchell JA, Warner TD
(
2001
)
.
Sodium salicylate inhibits prostaglandin formation without affecting the induction of cyclooxygenase-2 by bacterial lipopolysaccharide in vivo
.
J Pharmacol Exp Ther
vol.
299
,
(
3
)
894
-
900
.
Calatayud S, Warner TD, Breese EJ, Mitchell JA
(
2001
)
.
Relationship between endogenous colony stimulating factors and apoptosis in human colon cancer cells: role of cyclo-oxygenase inhibitors
.
BRIT J PHARMACOL
.
vol.
134
,
1237
-
1244
.
Zacharowski K, Thomas M, Wood EG, Bishop-Bailey D, Warner TD
(
2001
)
.
Cardioprotective effect of PPAR gamma receptor agonist rosiglitazone is abolished by cycloheximid or dexamethasone
.
CIRCULATION
.
vol.
104
,
53
-
53
.
Giuliano F, Ferraz JG, Pereira R, de Nucci G, Warner TD
(
2001
)
.
Cyclooxygenase selectivity of non-steroid anti-inflammatory drugs in humans: ex vivo evaluation
.
Eur J Pharmacol
vol.
426
,
(
1-2
)
95
-
103
.
Wort SJ, Woods M, Warner TD, Evans TW, Mitchell JA
(
2001
)
.
Endogenously released endothelin-1 from human pulmonary artery smooth muscle promotes cellular proliferation - Relevance to pathogenesis of pulmonary hypertension and vascular remodeling
.
AM J RESP CELL MOL
vol.
25
,
(
1
)
104
-
110
.
Sims EC, Powell MEB, Rothman MT, Warner TD
(
2001
)
.
Targeted radioimmunotherapy - Novel delivery of coronary artery radiation
.
BRIT J CANCER
.
vol.
85
,
17
-
17
.
Caliendo G, Santagada V, Perissutti E, Severino B, Fiorino F, Warner TD, Wallace JL, Ifa DR et al.
(
2001
)
.
Synthesis of substituted benzamides as anti-inflammatory agents that inhibit preferentially cyclooxygenase 1 but do not cause gastric damage
.
EUR J MED CHEM
vol.
36
,
(
6
)
517
-
530
.
Thomas MA, Bishop-Bailey D, Wood EG, Warner TD
(
2001
)
.
Biliverdin, the product of heme oxygenase metabolism attenuates SIN-1 induced apoptosis in WKY 3M-22 rat aortic smooth muscle cells
.
BRIT J PHARMACOL
.
vol.
133
,
U62
-
U62
.
Giuliano F, Warner TD
(
2001
)
.
COX-1-derived PGE(2): A comparison between human and rat blood
.
BRIT J PHARMACOL
.
vol.
133
,
U101
-
U101
.
Calatayud S, Allcock GH, Perretti M, Mitchell JA, Warner TD
(
2001
)
.
Comparison of the effects of the selective COX-2 inhibitor, DFP, and indomethacin on leukocyte-endothelial cell interactions in the rat mesentery
.
BRIT J PHARMACOL
.
vol.
133
,
U102
-
U102
.
Bardswell SC, Woods M, Bishop-Bailey D, Wood EG, Mitchell JA, Warner TD
(
2001
)
.
Effect of peroxisome proliferator-activated receptor agonists on cytokine-stimulated endothelin-1 production in human vascular smooth muscle cells
.
BRIT J PHARMACOL
.
vol.
133
,
U52
-
U52
.
Calatayud S, Warner TD, Mitchell JA
(
2001
)
.
Modulation of colony stimulating factor release and apoptosis in human colon cancer cells by anticancer drugs
.
BRIT J PHARMACOL
.
vol.
133
,
U126
-
U126
.
Bishop-Bailey D, Hla T, Warner TD
(
2001
)
.
Peroxisome proliferator-activated (PPAR) gamma ligands induce vascular smooth muscle cell apoptosis
.
BRIT J PHARMACOL
.
vol.
133
,
U18
-
U18
.
Gray PA, Breese EJ, Wood EG, Warner TD, Mitchell JA
(
2001
)
.
Respective effects of cAMP elevation versus cGMP elevation on GMCSF release by human synoviocytes
.
BRIT J PHARMACOL
.
vol.
133
,
U21
-
U21
.
Price S, Warner TD, Evans TW, Anning PB, Mitchell JA
(
2001
)
.
Role of endothelin-1 in modulation of cardiac function in endotoxaemia
.
BRIT J PHARMACOL
.
vol.
133
,
U4
-
U4
.
Wort SJ, Evans TW, Woods M, Warner TD, Mitchell JA
(
2001
)
.
Endogenously released endothelin-1 from human pulmonary artery smooth muscle promotes cellular proliferation
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
133
,
U35
-
U35
.
Woods M, Mayberry JL, Warner TD, Pollock JS, Pollock DM
(
2001
)
.
Interleukin-1β stimulates ET-1 release from inner medullary collecting duct cells
.
FASEB JOURNAL
.
vol.
15
,
A833
-
A833
.
Warner TD
(
2001
)
.
Introduction to "nimesulide: beyond COX-2"
.
Clin Exp Rheumatol
vol.
19
,
(
1 Suppl 22
)
S1
-
S2
.
Bennett A, Warner TD
(
2001
)
.
Nimesulide: Beyond COX-2 - EULAR Satellite Symposium (22 June 2000) - Foreword
.
CLIN EXP RHEUMATOL
vol.
19
,
(
1
)
II
-
II
.
Roland M, Bhowmik A, Sapsford RJ, Seemungal TA, Jeffries DJ, Warner TD, Wedzicha JA
(
2001
)
.
Sputum and plasma endothelin-1 levels in exacerbations of chronic obstructive pulmonary disease
.
Thorax
vol.
56
,
(
1
)
30
-
35
.
Roland MA, Patel I, Roberts NJ, Sapsford RJ, Warner T, Wedzicha JA
(
2000
)
.
The effect of clarithromycin on endothelin-1 production by primary bronchial epithelial cell cultures from COPD patients
.
THORAX
.
vol.
55
,
A6
-
A6
.
Vane, Warner T
(
2000
)
.
Nomenclature for COX-2 Inhibitors
.
The Lancet
vol.
356
,
(
9239
)
1373
-
1374
.
McCartney SA, Farthing MJ, Warner TD
(
2000
)
.
Pro-inflammatory cytokines reduce viability and induce apoptosis in HT-29 cells
.
Gastroenterology
.
vol.
118
,
Mitchell JA, Gray P, Anning PD, Woods M, Warner TD, Evans TW
(
2000
)
.
Effects of nitric oxide-modulating amino acids on coronary vessels: relevance to sepsis
.
European Journal of Pharmacology
vol.
389
,
(
2-3
)
209
-
215
.
Woods M, Wood EG, Mitchell JA, Warner TD
(
2000
)
.
Cyclic AMP Regulates Cytokine Stimulation of Endothelin-1 Release in Human Vascular Smooth Muscle Cells
.
Journal of Cardiovascular Pharmacology
.
vol.
36
,
s404
-
s406
.
Giuliano F, Vojnovic I, De Nucci G, Warner TD
(
2000
)
.
Cyclooxygenase selectivity of non-steroidal anti-inflammatory drugs (nSAIDs) in humans:: <i>Ex vivo</i> evaluation
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
129
,
U57
-
U57
.
Woods M, Wood EG, Mitchell JA, Warner TD
(
2000
)
.
Cytokine-stimulation of ET-1 release from human vascular smooth muscle cells (HVSMCs) is modulated by cAMP
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
129
,
U12
-
U12
.
Breese EJ, Patchett SE, Warner TD, Mitchell JA
(
2000
)
.
G-CSF production is elevated from antral biopsies of patients with gastritis, but only increased by indomethacin in patients negative for <i>Helicobacter pylori</i> infection
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
129
,
Woods M, Walcot NR, Wood EG, Mitchell JA, Warner TD
(
2000
)
.
IL-4 and IL-13 modulate cytokine-induced endothelin-1 production in human vascular smooth muscle cells
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
129
,
U109
-
U109
.
Gray PA, Warner TD, Vojnovic I, Parikh A, Scadding G, Del Soldato P, Mitchell JA
(
2000
)
.
Leukotriene production in human blood is reduced by NO-aspirin but not aspirin: Comparisons between responses in healthy volunteers and aspirin-sensitive asthmatics
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
129
,
U116
-
U116
.
Giuliano F, Warner TD
(
2000
)
.
No evidence that sodium salicylate inhibits LPS-induced expression of COX-2 in anaesthetised rats
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
131
,
U14
-
U14
.
Sims EC, Powell MEB, Rothman MT, Warner TD
(
2000
)
.
Optimising coronary artery radiation using targeted radioimmunotherapy
.
BRITISH JOURNAL OF CANCER
vol.
83
,
33
-
33
.
Woods M, Wood EG, Mitchell JA, Warner TD
(
2000
)
.
Signal Transduction Pathways Involved in Cytokine Stimulation of Endothelin-1 Release from Human Vascular Smooth Muscle Cells
.
Journal of Cardiovascular Pharmacology
.
vol.
36
,
s407
-
s409
.
Wort SJ, Mitchell JA, Woods M, Evans TW, Warner TD
(
2000
)
.
The Prostacyclin-Mimetic Cicaprost Inhibits Endogenous Endothelin-1 Release From Human Pulmonary Artery Smooth Muscle Cells
.
Journal of Cardiovascular Pharmacology
.
vol.
36
,
s410
-
s413
.
Wort SJ, Evans TW, Woods M, Warner TD, Mitchell JA
(
1999
)
.
Cicaprost, a stable prostacyclin analogue, inhibits endogenous endothelin-1 release in human pulmonary artery smooth muscle cells
.
Thorax
vol.
54
,
(
SUPPL. 3
)
Wort SJ, Evans TW, Warner TD, Mitchell JA
(
1999
)
.
Cyclooxygenase-2 induction represents an endogenous 'brake' on ET-1 production by human pulmonary artery smooth muscle
.
Thorax
vol.
54
,
(
SUPPL. 3
)
(
1999
)
.
Correction
.
Proceedings of the National Academy of Sciences of the United States of America
vol.
96
,
(
17
)
9966
-
9966
.
Brooks P, Emery P, Evans JF, Fenner H, Hawkey CJ, Patrono C, Smolen J, Breedveld F et al.
(
1999
)
.
Interpreting the clinical significance of the differential inhibition of cyclooxygenase-1 and cyclooxygenase-2
.
Rheumatology
vol.
38
,
(
8
)
779
-
788
.
Warner TD, Giuliano F, Vojnovic I, Bukasa A, Mitchell JA, Vane JR
(
1999
)
.
Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis
.
Proceedings of the National Academy of Sciences of the United States of America
vol.
96
,
(
13
)
7563
-
7568
.
Woods M, Mitchell JA, Wood EG, Barker S, Walcot NR, Rees GM, Warner TD
(
1999
)
.
Endothelin-1 is induced by cytokines in human vascular smooth muscle cells: evidence for intracellular endothelin-converting enzyme
.
Molecular Pharmacology
vol.
55
,
(
5
)
902
-
909
.
Saunders MA, Belvisi MG, Cirino G, Barnes PJ, Warner TD, Mitchell JA
(
1999
)
.
Mechanisms of prostaglandin E2 release by intact cells expressing cyclooxygenase-2: evidence for a 'two-component' model
.
Journal of Pharmacology and Experimental Therapeutics
vol.
288
,
(
3
)
1101
-
1106
.
Chen G, Wood EG, Wang SH, Warner TD
(
1999
)
.
Expression of cyclooxygenase-2 in rat vascular smooth muscle cells is unrelated to nuclear factor-κB activation
.
Life Sciences
vol.
64
,
(
14
)
1231
-
1242
.
HAMILTON LC, MITCHELL JA, TOMLINSON AM, WARNER TD
(
1999
)
.
Synergy between cyclo‐oxygenase‐2 induction and arachidonic acid supply in vivo: consequences for nonsteroidal antiinflammatory drug efficacy
.
The FASEB Journal
vol.
13
,
(
2
)
245
-
251
.
Woods M, Wood EG, Lees DM, Mitchell JA, Warner TD
(
1999
)
.
A role for NF-κB in the stimulation by cytokines of endothelin-1 release in human vascular smooth muscle cells
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
128
,
U14
-
U14
.
Gray PA, Breese EJ, Wood EG, Del Soldato P, Warner TD, Mitchell JA
(
1999
)
.
Comparison of NSAIDs and NO-NSAIDs on PGE<sub>2</sub> and GMCSF production by human synoviocytes
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
128
,
U54
-
U54
.
Hamilton LC, Warner TD
(
1999
)
.
Death of rat aortic smooth muscle cells is reduced by heme oxygenase-1 induction and exogenous biliverdin
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
126
,
U28
-
U28
.
Woods M, Wood EG, Mitchell JA, Warner TD
(
1999
)
.
Effect of tyrosine kinase inhibitors on cytokine-stimulated endothelin production in human vascular smooth muscle cells
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
126
,
U94
-
U94
.
Breese EJ, Wood EG, Curtis MJ, Warner TD, Mitchell JA
(
1999
)
.
Effects of COX-1 and COX-2-selective NSAIDs on prostaglandin E<sub>2</sub> and GM-CSF production by human synoviocytes
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
126
,
U83
-
U83
.
Breese EJ, Wood EG, Gray PA, Curtis MJ, Warner TD, Mitchell JA
(
1999
)
.
Effects of disease modifying anti-rheumatic drugs and corticosteroids on prostaglandin E<sub>2</sub>, and GMCSF production by cytokine-stimulated human synoviocytes
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
128
,
U17
-
U17
.
Warner TD
(
1999
)
.
Endothelin Receptors and Ligands
.
Pulmonary Actions of the Endothelins
,
Springer Nature
McCartney SA, Mitchell JA, Warner TD, Farthing MJG
(
1999
)
.
GM-CSF is produced in high concentrations by colonic mucosa from patients with ulcerative colitis and is down regulated by co-incubation with dexamethasone
.
GASTROENTEROLOGY
.
vol.
116
,
A713
-
A713
.
McCartney SA, Mitchell JA, Farthing MJG, Warner TD
(
1999
)
.
GM-CSF is produced in high concentrations by inflamed colonic mucosa from patients with ulcerative colitis and is down-regulated by co-incubation with dexamethasone
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
126
,
U78
-
U78
.
McCartney SA, Farthing MJG, Warner TD
(
1999
)
.
Inhibition of COX-2 does not correlate with ability to induce apoptosis in HT-29 cells
.
GASTROENTEROLOGY
.
vol.
116
,
A401
-
A401
.
McCartney SA, Farthing MJG, Warner TD
(
1999
)
.
Inhibition of COX-2 does not correlate with ability to induce apoptosis in HT-29 cells
.
GUT
.
vol.
44
,
A82
-
A82
.
Thiemermann C, Warner TD
(
1999
)
.
Nitric oxide and endothelin-1 in circulatory shock involving cytokines
.
Cytokines in Severe Sepsis and Septic Shock
,
Springer Nature
Warner TD, Giuliano F, Vojnovic I, Bukasa A, Mitchell JA, Vane JR
(
1999
)
.
Nonsteroid drug selectives for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity:: A full <i>in vitro</i> analysis (vol 96, pg 7563, 1999)
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
vol.
96
,
(
17
)
9966
-
9966
.
Bukasa A, Vojnovic I, Giuliano F, Saunders M, Mitchell JA, Warner TD
(
1999
)
.
Selectivities of non-steroidal anti-inflammatory drugs as inhibitors of purified ovine COX-1 and COX-2: Effects of human plasma
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
126
,
U83
-
U83
.
Woods M, Wood EG, Mitchell JA, Warner TD
(
1999
)
.
Studies with CGS 26303, an inhibitor of endothelin converting enzyme, supports the presence of intracellular endothelin-converting enzyme in human vascular smooth muscle cells
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
126
,
U30
-
U30
.
Breese EJ, Warner TD, Patchett SE, Mitchell JA
(
1999
)
.
The prostacyclin analogue cicaprost reverses the increase in GM-CSF production caused by NSAID treatment of human gastric biopsies
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
128
,
U15
-
U15
.
Walcot NRH, Woods M, Wood EG, Rees GM, Warner TD
(
1999
)
.
The role of vascular smooth muscle cells in serum and cytokine-stimulated endothelin-1 production in intact rat aorta
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
126
,
U94
-
U94
.
Chen G, Kamal M, Hannon R, Warner TD
(
1998
)
.
Regulation of Cyclo-oxygenase Gene Expression in Rat Smooth Muscle Cells by Catalase
.
Biochemical Pharmacology
vol.
55
,
(
10
)
1621
-
1631
.
Warner TD, McCartney SA
(
1998
)
.
Shock news for the gut
.
Gut
vol.
42
,
(
5
)
McCartney, Ballinger, Azooz O, Warner T, Farthing M
(
1998
)
.
Endothelin levels in trinitrobenzenesulphonic acid (TNBS)-induced colitis do not reflect those in human inflammatory bowel disease (IBD)
.
Gastroenterology
vol.
114
,
McCartney, Vojnovic I, Farthing MJ, Warner T
(
1998
)
.
Nonsteroidal drug (NSAID)-induced fall in HT-29 cell viability correlates with potency to inhibit cyclooxygenase (COX) 1: Use of COX-2 selective inhibitors
.
Gastroenterology
vol.
114
,
McCartney, Mitchell J, Vojnovic I, Farthing M, Warner T
(
1998
)
.
Prostanoid production in human inflammatory bowel disease (IBD) is dependent upon cyclo-oxygenase 2: Use of selective inhibitors
.
Gastroenterology
vol.
114
,
Hamilton LC, Warner TD
(
1998
)
.
Methaemoglobin induces HO-1 in RASM by release of free radicals
.
FASEB Journal
vol.
12
,
(
5
)
Warner TD, McCartney SA
(
1998
)
.
NOS inhibitors in colitis: a suitable case for treatment?
.
Gut
vol.
42
,
(
2
)
Giuliano F, Warner TD
(
1998
)
.
<i>Ex vivo </i>assay to determine the cyclooxygenase selectivity of non-steroidal anti-inflammatory drugs
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
125
,
U19
-
U19
.
Warner TD
(
1998
)
.
Characterisation of endothelin receptors within the vasculature: Endothelium versus smooth muscle
.
JOURNAL OF NEUROCHEMISTRY
.
vol.
71
,
S74
-
S74
.
Woods M, Bishop-Bailey D, Pepper JR, Evans TW, Mitchell JA, Warner TD
(
1998
)
.
Cytokine and Lipopolysaccharide Stimulation of Endothelin-1 Release from Human Internal Mammary Artery and Saphenous Vein Smooth-Muscle Cells
.
Journal of Cardiovascular Pharmacology
vol.
31
,
s348
-
s350
.
Woods M, Wood EG, Mitchell JA, Warner TD
(
1998
)
.
Evidence for intracellular endothelin converting enzyme in human vascular smooth muscle cells
.
FASEB JOURNAL
.
vol.
12
,
A384
-
A384
.
Hamilton LC, Jimenez C, Warner TD
(
1998
)
.
Heme oxygenase-1 induction has no significant effect on the vascular reactivity of rat aortic rings
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
125
,
U53
-
U53
.
McCartney SA, Vojnovic I, Farthing MJG, Warner TD
(
1998
)
.
Nonsteroidal drug (NSAID)-induced fall in HT-29 cell viability correlates with potency to inhibit cyclooxygenase (COX)1: Use of COX-2 selective inhibitors
.
GUT
.
vol.
42
,
A1
-
A1
.
McCartney SA, Mitchell JA, Vojnovic I, Farthing MJG, Warner TD
(
1998
)
.
Prostanoid production in human inflammatory bowel disease (IBD) is dependent upon cyclooxygenase 2: Use of selective inhibitors
.
GUT
.
vol.
42
,
A43
-
A43
.
D’Amico M, Di Filippo C, Rossi F, Warner TD
(
1998
)
.
Role of AT2 receptors in the cardiovascular events following microinjection of angiotensin II into the superior colliculus of anaesthetised rats
.
Naunyn-Schmiedeberg's Archives of Pharmacology
vol.
357
,
(
2
)
121
-
125
.
Hamilton LC, Tomlinson A, Dye LJ, Mitchell JA, Warner TD
(
1998
)
.
Use of selective enzyme inhibitors provide NO evidence for cross-talk between inducible nitric oxide synthase and cyclooxygenase-2 in endotoxin-treated rats
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
123
,
U25
-
U25
.
D'Amico M, Rossi F, Warner TD
(
1997
)
.
Regulation of blood pressure by l-arginine-nitric oxide pathway within the superior colliculus of rats
.
European Journal of Pharmacology
vol.
328
,
(
1
)
65
-
67
.
Chen G, Warner TD
(
1997
)
.
A Single Competitive Reverse Transcriptase-Polymerase Chain Reaction Assay to Measure Inducible Nitric Oxide Synthase Gene Expression in Both Human and Rat
.
Analytical Biochemistry
vol.
247
,
(
2
)
455
-
458
.
Allcock GH, Warner TD
(
1997
)
.
Activation of ETa receptors is partially responsible for the rapid increase in haematocrit induced by bacterial lipopolysaccharide in the rat
.
Life Sciences
vol.
60
,
(
19
)
pl271
-
pl276
.
Takahashi T, Barnes PJ, Kawikova I, Yacoub MH, Warner TD, Belvisi MG
(
1997
)
.
Contraction of human airway smooth muscle by endothelin-1 and IRL 1620: effect of bosentan
.
European Journal of Pharmacology
vol.
324
,
(
2-3
)
219
-
222
.
DAmico M, Rossi F, Warner TD
(
1997
)
.
Cardiovascular events following micro-injection of angiotensin II, endothelin-1 or L-NAME to the superior colliculus of rats
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
120
,
P118
-
P118
.
Woods M, BishopBailey D, Pepper JR, Evans TW, Mitchell JA, Warner TD
(
1997
)
.
Cytokine and LPS stimulation of endothelin-1 release from internal mammary artery and saphenous vein smooth muscle cells
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
122
,
P18
-
P18
.
McCartney SA, Greaves RGR, Warner TD, Domizio P, Farthing MJG
(
1997
)
.
Endothelin content but not expression is reduced in inflamed gallbladders
.
GASTROENTEROLOGY
.
vol.
112
,
A517
-
A517
.
Hamilton LC, Mitchell JA, Warner TD
(
1997
)
.
Induction of COX-2 in vivo leads to greatly increased production of 6-keto-PGF(1 alpha) following administration of exogenous arachidonic acid or bradykinin
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
122
,
P22
-
P22
.
McCartney SA, Warner TD, Woods M, Fairclough PD, Farthing MJG
(
1997
)
.
Low tissue endothelin levels in inflammatory bowel disease, despite enhanced ET-2 gene expression
.
GASTROENTEROLOGY
.
vol.
112
,
A1036
-
A1036
.
Hamilton LC, Vojnovic I, Bakhle YS, Warner TD, Vane JR
(
1997
)
.
The anti-inflammatory drug leflunomide inhibits in vitro and in vivo the activity of COX-2 more potently than the induction of COX-2 or INOS
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
120
,
P49
-
P49
.
D'Amico M, Rossi F, Warner TD
(
1996
)
.
Cardiovascular responses induced by injection of endothelin-1 into the superior colliculus of rats
.
European Journal of Pharmacology
vol.
316
,
(
2-3
)
245
-
247
.
Warner TD
(
1996
)
.
Influence of endothelial mediators on the vascular smooth muscle and circulating platelets and blood cells
.
International Angiology
vol.
15
,
(
2
)
93
-
99
.
Warner TD, Elliott JD, Ohlstein EH
(
1996
)
.
California dreamin' 'bout endothelin: emerging new therapeutics
.
Trends in Pharmacological Sciences
vol.
17
,
(
5
)
177
-
181
.
Warner TD, Klemm P
(
1996
)
.
What turns on the endothelins?
.
Inflammation Research
vol.
45
,
(
2
)
51
-
53
.
DAmico M, Dashwood MR, Warner TD
(
1996
)
.
Endothelin-1 and rat periaqueductal gray area: An autoradiographic and functional pharmacological study
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
117
,
P12
-
P12
.
Allcock GH, Warner TD
(
1996
)
.
Endothelin-A receptor activation is partially responsible for the acute increase in haematocrit induced by LPS
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
118
,
P95
-
P95
.
Kamal M, Vojnovic I, Wood EG, Warner TD, Vane JR
(
1996
)
.
Potencies of nonsteroid antiinflammatory drugs as inhibitors of PGE(2) production by COX-2 containing A549 cells vary with cellular stimuli
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
119
,
P241
-
P241
.
Allcock GH, Battistini B, Fournier A, Warner TD, Vane JR
(
1995
)
.
Characterization of endothelin receptors mediating mechanical responses to the endothelins in the isolated stomach strip of the rat
.
Journal of Pharmacology and Experimental Therapeutics
vol.
275
,
(
1
)
120
-
126
.
Battistini B, Botting R, Warner TD
(
1995
)
.
Endothelin: a knockout in London
.
Trends in Pharmacological Sciences
vol.
16
,
(
7
)
217
-
222
.
Goto K, Warner TD
(
1995
)
.
Endothelin versatility
.
Nature
vol.
375
,
(
6532
)
539
-
540
.
Klemm P, Warner TD, Hohlfeld T, Corder R, Vane JR
(
1995
)
.
Endothelin 1 mediates ex vivo coronary vasoconstriction caused by exogenous and endogenous cytokines
.
Proceedings of the National Academy of Sciences of the United States of America
vol.
92
,
(
7
)
2691
-
2695
.
ALLCOCK GH, WARNER TD, VANE JR
(
1995
)
.
ANTAGONISM OF ENDOTHELIN-A-RECEPTORS, BUT NOT ENDOTHELIN-B-RECEPTORS, ATTENUATES THE REGIONAL AND SYSTEMIC HEMODYNAMIC-CHANGES TO ENDOTHELIN-1 IN THE ANESTHETIZED RAT
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
114
,
P80
-
P80
.
BATTISTINI B, ALLCOCK GH, WARNER TDC, VANE JR
(
1995
)
.
CHARACTERIZATION OF ENDOTHELIN RECEPTORS MEDIATING CONTRACTION AND RELAXATION IN THE ISOLATED FUNDUS OF THE RAT STOMACH
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
114
,
P77
-
P77
.
KLEMM P, HOHLFELD T, CORDER R, WARNER TD, THIEMERMANN C, VANE JR
(
1995
)
.
ENDOTHELIN-1 CONTRIBUTES TO THE EX-VIVO INCREASE IN PERFUSION-PRESSURE IN HEARTS TAKEN FROM IL-2-TREATED RATS
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
114
,
P78
-
P78
.
BATTISTINI B, ODONNELL LJD, WARNER TD, FOURNIER A, VANE JR, FARTHING MJG
(
1995
)
.
ENDOTHELIN-INDUCED CONTRACTIONS IN THE ISOLATED GALLBLADDER OF THE GUINEA-PIG INVOLVE THE RELEASE OF PROSTAGLANDINS
.
GASTROENTEROLOGY
.
vol.
108
,
A951
-
A951
.
Klemm P, Warner TD, Corder R, Vane JR
(
1995
)
.
Endothelin-1 Mediates Coronary Vasoconstriction Caused by Exogenous and Endogenous Cytokines
.
Journal of Cardiovascular Pharmacology
vol.
26
,
s419
-
s421
.
Kengatharan M, Battistini B, Warner TD, Thiemermann C, Vane JR
(
1995
)
.
Endothelin-1 Mediates the Increase in Ex Vivo Coronary Vascular Resistance Induced by Hemorrhagic Shock in the Anesthetized Rat
.
Journal of Cardiovascular Pharmacology
.
vol.
26
,
s422
-
s424
.
Warner TD, Dunn MJ, Kimura SK, Stewart DJ, Yanagisawa M, Masaki T, Vane JR
(
1995
)
.
Endothelins: Recent Progress
.
Pharmacological Sciences: Perspectives for Research and Therapy in the Late 1990s
,
Springer Nature
BATTISTINI B, WARNER TD, ODONNELL LJD, FARTHING MJG, VANE JR
(
1995
)
.
INVESTIGATIONS INTO CHOLECYSTOKININ (CCK) RECEPTOR AGONIST ACTIVITY OF ANTAGONISTS OF ET(A) OR ET(H) RECEPTORS
.
GASTROENTEROLOGY
.
vol.
108
,
A951
-
A951
.
Allcock GH, Warner TD
(
1995
)
.
Inhibition of ETB Receptors Limits the Efficacy of Nonselective Endothelin Antagonists In Vivo
.
Journal of Cardiovascular Pharmacology
.
vol.
26
,
s177
-
s179
.
HYNES CL, WARNER TD, WOOD EG, VANE JR
(
1995
)
.
PROLONGED PROSTACYCLIN PRODUCTION BY BOVINE AORTIC ENDOTHELIAL-CELLS IS INCREASED EQUALLY BY BRIEF AND PROLONGED PERIODS OF STRETCH
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
114
,
P181
-
P181
.
COOPER AC, PEREZVIZCAINO F, CORDER R, FOURNIER A, WARNER TD
(
1995
)
.
RAPID DEGRADATION OF ENDOTHELIN-1 BY AN ENZYME RELEASED BY THE RAT ISOLATED-PERFUSED MESENTERY
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
114
,
P197
-
P197
.
WOODS M, BATTISTINI B, WARNER TD, ODONNELL LJD, FARTHING MJG, VANE JR
(
1995
)
.
SPECIFIC HIGH-AFFINITY AND LOW-AFFINITY BINDING-SITES FOR ENDOTHELIN-1 IN GUINEA-PIG GALLBLADDER MEMBRANES
.
GASTROENTEROLOGY
.
vol.
108
,
A1016
-
A1016
.
HYNES CL, WOOD EG, WARNER TD
(
1995
)
.
STRETCH OF CULTURED BOVINE AORTIC ENDOTHELIAL, CELLS INCREASES THE PRODUCTION OF NITRIC-OXIDE AND SO REDUCES STIMULATED PLATELET-ADHESION
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
116
,
P65
-
P65
.
Warner TD, Sorrentino R, Allcock GH, Battistini B, Vane JR
(
1995
)
.
The non-selective endothelin receptor antagonist, PD 145065 inhibits bronchoconstrictions induced by endothelin-1 or sarafotoxin 6C in the anaesthetised guinea-pig
.
Pharmacology Communications
vol.
5
,
(
3
)
163
-
169
.
Warner TD, Battistini B, Doherty AM, Corder R
(
1994
)
.
Endothelin receptor antagonists: Actions and rationale for their development
.
Biochemical Pharmacology
vol.
48
,
(
4
)
625
-
635
.
Macarthur H, Warner TD, Wood EG, Corder R, Vane JR
(
1994
)
.
Endothelin-1 Release from Endothelial Cells in Culture Is Elevated Both Acutely and Chronically by Short Periods of Mechanical Stretch
.
Biochemical and Biophysical Research Communications
vol.
200
,
(
1
)
395
-
400
.
Battistini B, Warner TD, Fournier A, Vane JR
(
1994
)
.
Comparison of PD 145065 and Ro 46-2005 as antagonists of contractions of guinea-pig airways induced by endothelin-1 or IRL 1620
.
European Journal of Pharmacology
vol.
252
,
(
3
)
341
-
345
.
Warner TD, Battistini B
(
1994
)
.
Advances in endothelin inhibitors
.
Drug News and Perspectives
.
vol.
7
,
429
-
436
.
BATTISTINI B, ODONNELL LJD, WARNER TD, FOURNIER A, FARTHING MJG, VANE JR
(
1994
)
.
CHARACTERIZATION OF AN ENDOTHELIN-CONVERTING ENZYME-ACTIVITY IN THE ISOLATED GALLBLADDER OF THE GUINEA-PIG
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
112
,
U34
-
U34
.
BATTISTINI B, ODONNELL LJD, WARNER TD, FOURNIER A, FARTHING MJG, VANE JR
(
1994
)
.
CHARACTERIZATION OF ENDOTHELIN RECEPTORS IN THE ISOLATED GALLBLADDER OF THE GUINEA-PIG
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
112
,
U61
-
U61
.
BRYANT CE, ALLCOCK GH, WARNER TD, VANE JR
(
1994
)
.
COMPARISON OF THE CARDIOVASCULAR-RESPONSES TO CHRONIC AND ACUTE TREATMENT WITH L-NITROARGININE METHYL-ESTER IN THE RAT
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
112
,
U10
-
U10
.
BATTISTINI B, ODONNELL LJD, WARNER TD, FOURNIER A, FARTHING MJG, VANE JR
(
1994
)
.
CONTRACTILE ACTIVITY OF ENDOTHELIN PRECURSORS IN THE ISOLATED GALLBLADDER OF THE GUINEA-PIG
.
FASEB JOURNAL
.
vol.
8
,
A570
-
A570
.
SWIERKOSZ TA, WARNER TD, VANE JR
(
1994
)
.
DISCREPANCY BETWEEN VASORELAXATIONS INDUCED BY N-G-HYDROXY-L-ARGININE AND ITS EFFECTS ON THE FORMATION OF CYCLIC-GMP
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
112
,
U117
-
U117
.
BATTISTINI B, WARNER TD, VANE JR
(
1994
)
.
EFFECTS INDUCED BY LINEAR PEPTIDE ANTAGONISTS SELECTIVE FOR ET(A) RECEPTORS - A STUDY IN DIFFERENT SMOOTH-MUSCLE PREPARATIONS
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
112
,
U62
-
U62
.
ODONNELL LJD, BATTISTINI B, WARNER TD, FOURNIER A, VANE JR, FARTHING MJG
(
1994
)
.
ENDOTHELIN-INDUCED GALLBLADDER CONTRACTILITY IN-VITRO
.
GASTROENTEROLOGY
.
vol.
106
,
A353
-
A353
.
Warner TD, Mitchell JA, Sheng H, Murad F
(
1994
)
.
Effects of Cyclic GMP on Smooth Muscle Relaxation
.
vol.
26
,
Elsevier
ODONNELL LJD, BATTISTINI B, WARNER TD, FOURNIER A, VANE JR, FARTHING MJG
(
1994
)
.
HIGH-ACTIVITY OF ENDOTHELIN-CONVERTING ENZYME IN GUINEA-PIG GALLBLADDER
.
GASTROENTEROLOGY
.
vol.
106
,
A353
-
A353
.
Mealy K, Adeyoju A, O’Nullain E, Smyth H, Keane FBV, Reen D, Tanner A, Wang JH et al.
(
1994
)
.
Irish society for gastroenterology
.
Irish Journal of Medical Science
vol.
163
,
(
1
)
37
-
47
.
SORRENTINO R, WARNER TD, ALLCOCK GH, FOURNIER A, BATTISTINI B, VANE JR
(
1994
)
.
PD-145065 BUT NOT BQ-123 BLOCKS BRONCHOCONSTRICTION INDUCED BY INTRAVENOUS ENDOTHELIN-1 OR SARAFOTOXIN 6C IN THE ANESTHETIZED GUINEA-PIG
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
112
,
U61
-
U61
.
Swierkosz TA, Mitchell JA, Tomlinson A, Botting RM, Warner TD, Vane JR
(
1994
)
.
Relationship between different isoforms of nitric oxide synthase and cyclooxygenase in various cell types
.
Pharmacological Reports
vol.
46
,
(
6
)
587
-
592
.
Moynihan HA, Roberts SM, Weldon H, Allcock GH, Änggård EE, Warner TD
(
1994
)
.
Synthesis and biological activity of the novel nitric oxide synthase inhibitor N ω′ -hydroxy- N ω -methyl- L -arginine
.
Journal of the Chemical Society Perkin Transactions 1
vol.
0
,
(
7
)
769
-
771
.
BATTISTINI B, WARNER TD, FOURNIER A, JOHN RR
(
1994
)
.
THE EFFECTS OF 2 ET(A)/ET(B) RECEPTOR ANTAGONISTS, PD-145065 AND RO-46-2005, ON CONTRACTIONS INDUCED BY ET-1 OR IRL-1620 IN THE ISOLATED BRONCHUS OF THE GUINEA-PIG
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
112
,
U60
-
U60
.
ALLCOCK GH, WARNER TD, VANE JR
(
1994
)
.
THE ENDOTHELIN RECEPTOR ANTAGONISTS BQ-123 AND PD-145065 REVERSE ESTABLISHED PRESSOR-RESPONSES TO ENDOTHELIN-1 IN THE ANESTHETIZED RAT
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
112
,
U82
-
U82
.
Battistini B, Warner TD, Corder R
(
1994
)
.
Update on endothelin research
.
Drug News and Perspectives
.
vol.
7
,
249
-
253
.
Warner TD, Battistini B, Allcock GH, Vane JR
(
1993
)
.
Endothelin ETA and ETB receptors mediate vasoconstriction and prostanoid release in the isolated kidney of the rat
.
European Journal of Pharmacology
vol.
250
,
(
3
)
447
-
453
.
Warner TD
(
1993
)
.
Characterization of endothelin synthetic pathways and receptor subtypes: physiological and pathophysiological implications
.
European Heart Journal
.
vol.
14 Suppl I
,
42
-
47
.
Warner TD, Vane JR
(
1993
)
.
ET touches down in Houston
.
Nature
vol.
362
,
(
6420
)
497
-
498
.
DESAI KM, WARNER TD, VANE JR
(
1993
)
.
5-HT3 RECEPTORS DO NOT MEDIATE THE RESPONSES OF THE GUINEA-PIG ISOLATED STOMACH TO VAGAL-STIMULATION
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
109
,
P54
-
P54
.
WELLINGS RP, WARNER TD, CORDER R, CRISTOL JP, THIEMERMANN C, VANE JR
(
1993
)
.
A NEW NONSELECTIVE ENDOTHELIN ANTAGONIST BLOCKS THE VASOCONSTRICTION INDUCED BY ENDOTHELIN-1 IN THE RAT-KIDNEY, BOTH INVIVO AND INVITRO
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
108
,
P110
-
P110
.
Warner TD, Allcock GH, Mickley EJ, Corder R, Vane JR
(
1993
)
.
Comparative Studies with the Endothelin Receptor Antagonists BQ-123 and PD 142893 Indicate At Least Three Endothelin Receptors
.
Journal of Cardiovascular Pharmacology
vol.
22
,
(
Supplement 8
)
s117
-
s120
.
ALLCOCK GH, WARNER TD, VANE JR
(
1993
)
.
DIFFERENT EFFECTS OF ENDOTHELINS AND SARAFOTOXINS ON NEUTROTRANSMISSION IN THE GUINEA-PIG ILEUM AND RAT VAS-DEFERENS ARE MEDIATED BY DIFFERENT RECEPTORS
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
108
,
P165
-
P165
.
BATTISTINI B, ALLCOCK GH, WARNER TD, VANE JR
(
1993
)
.
ET(A) AND ET(B) RECEPTORS MEDIATE THE RELEASE OF EICOSANOIDS FROM THE RAT-KIDNEY INDUCED BY ENDOTHELIN SARAFOTOXIN PEPTIDES
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
110
,
P46
-
P46
.
DESAI KM, WARNER TD, BISHOP AE, POLAK JM, VANE JR
(
1993
)
.
IN-VITRO AND IMMUNOHISTOCHEMICAL STUDIES SUGGEST THAT NITRIC-OXIDE, AND NOT VIP, MEDIATES VAGALLY-INDUCED GASTRIC RELAXATION IN THE GUINEA-PIG
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
110
,
P50
-
P50
.
MICKLEY EJ, WARNER TD, VANE JR
(
1993
)
.
L-CANAVANINE INHIBITS THE RECYCLING OF L-CITRULLINE TO L-ARGININE IN THE RAT ANOCOCCYGEUS MUSCLE
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
110
,
P87
-
P87
.
MITCHELL JA, SWIERKOSZ TA, WARNER TD, GROSS S, THIEMERMANN C, VANE JR
(
1993
)
.
REGULATION OF PROSTACYCLIN SYNTHESIS BY THE RELEASE OF ENDOGENOUS NITRIC-OXIDE IN RESPONSE TO BACTERIAL LIPOPOLYSACCHARIDE
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
109
,
P4
-
P4
.
MACARTHUR H, WOOD EG, NAIR S, HENDERSON B, WARNER TD, VANE JR
(
1993
)
.
STRETCHING, BOTH ACUTELY AND CHRONICALLY, OF ENDOTHELIAL-CELLS INCREASES THEIR PRODUCTION OF PROSTACYCLIN AND ENDOTHELIN
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
110
,
P48
-
P48
.
ALLCOCK GH, WARNER TD, VANE JR
(
1993
)
.
THE ENDOTHELIN RECEPTOR ANTAGONISTS BQ-123 AND PD-145065 REVERSE ESTABLISHED VASOCONSTRICTOR RESPONSES TO ENDOTHELIN-1 IN-VITRO
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
110
,
P150
-
P150
.
WARNER TD, ALLCOCK GH, VANE JR
(
1993
)
.
THE ENDOTHELIN-RECEPTOR ANTAGONIST PD142893 INHIBITS ENDOTHELIUM-DEPENDENT VASODILATATIONS INDUCED BY ENDOTHELIN SARAFOTOXIN PEPTIDES
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
109
,
P56
-
P56
.
Kaw S, Warner TD, Vane JR
(
1993
)
.
The Metabolism of Endothelin-1 and Big Endothelin-1 by the Isolated Perfused Kidney of the Rabbit
.
Journal of Cardiovascular Pharmacology
.
vol.
22
,
s65
-
s68
.
Wellings RP, Warner TD, Thiemermann C, Cristol J, Corder R, Vane JR
(
1993
)
.
Vasoconstriction in the Rat Kidney Induced by Endothelin-1 Is Blocked by PD 145065
.
Journal of Cardiovascular Pharmacology
vol.
22
,
(
Supplement 8
)
s103
-
s106
.
Vincent SR
(
1992
)
.
Nitric Oxide and Arginine-Evoked Insulin Secretion
.
Science
vol.
258
,
(
5086
)
1376
-
1378
.
Schmidt HHHW, Warner TD, Ishii K, Sheng H, Murad F
(
1992
)
.
Response
.
Science
vol.
258
,
(
5086
)
1376
-
1378
.
Schmidt HHHW, Warner TD, Ishii K, Sheng H, Murad F
(
1992
)
.
Response: Nitric Oxide and Arginine-Evoked Insulin Secretion
.
Science
vol.
258
,
(
5086
)
1376
-
1378
.
Warner TD, Förstermann U, Ishii K, Mitchell JA, Nakane M, Pollock JS, Schmidt HHHW, Sheng H et al.
(
1992
)
.
Bioassay for EDRF/NO by accumulation of cyclic GMP in RFL-6 fetal rat lung fibroblasts
.
Methods
vol.
1
,
(
2
)
117
-
123
.
Mitchell JA, Kohlhaas KL, Matsumoto T, Pollock JS, Förstermann U, Warner TD, Schmidt HH, Murad F
(
1992
)
.
Induction of NADPH-dependent diaphorase and nitric oxide synthase activity in aortic smooth muscle and cultured macrophages
.
Molecular Pharmacology
vol.
41
,
(
6
)
1163
-
1168
.
Warner TD, Schmidt HH, Murad F
(
1992
)
.
Interactions of endothelins and EDRF in bovine native endothelial cells: selective effects of endothelin-3
.
American Journal of Physiology
vol.
262
,
(
5
)
h1600
-
h1605
.
Kaw S, Hecker M, Southan GJ, Warner TD, Vane JR
(
1992
)
.
Characterization of Serine Protease-Derived Metabolites of Big Endothelin in the Cytosolic Fraction from Human Polymorphonuclear Leukocytes
.
Journal of Cardiovascular Pharmacology
.
vol.
20
,
s22
-
s24
.
Warner TD, Budzik GP, Mitchell JA, Huang Z, Murad F
(
1992
)
.
Detection by Bioassay and Specific Enzyme-Linked Immunosorbent Assay of Phosphoramidon-Inhibitable Endothelin-Converting Activity in Brain and Endothelium
.
Journal of Cardiovascular Pharmacology
.
vol.
20
,
s19
-
s21
.
Schmidt HHHW, Warner T, Murad F
(
1992
)
.
Double-edged role of endogenous nitric oxide
.
The Lancet
vol.
339
,
(
8799
)
Schmidt HH, Warner TD, Nakane M, Förstermann U, Murad F
(
1992
)
.
Regulation and subcellular location of nitrogen oxide synthases in RAW264.7 macrophages
.
Molecular Pharmacology
vol.
41
,
(
4
)
615
-
624
.
Schmidt HHHW, Warner TD, Ishii K, Sheng H, Murad F
(
1992
)
.
Insulin Secretion from Pancreatic B Cells Caused by L-Arginine-Derived Nitrogen Oxides
.
Science
vol.
255
,
(
5045
)
721
-
723
.
Warner TD, Mitchell JA, D'Orleans-Juste P, Ishii K, Förstermann U, Murad F
(
1992
)
.
Characterization of endothelin-converting enzyme from endothelial cells and rat brain: detection of the formation of biologically active endothelin-1 by rapid bioassay
.
Molecular Pharmacology
vol.
41
,
(
2
)
399
-
403
.
WARNER TD, ALLCOCK GH, CORDER R, VANE JR
(
1992
)
.
BQ123 AND DIFFERENT ISOLATED TISSUE PREPARATIONS REVEAL HETEROGENEITY IN THE RECEPTORS MEDIATING CONTRACTIONS TO ENDOTHELIN-1
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
107
,
P103
-
P103
.
BUDZIK GP, DILLON TP, WARNER TD, OPGENORTH TJ
(
1992
)
.
CONVERSION OF EXOGENOUS BIG ENDOTHELIN-1 (BET-1) TO ENDOTHELIN-1 (ET-1) BY BOVINE AORTA
.
FASEB JOURNAL
.
vol.
6
,
A1456
-
A1456
.
MITCHELL JA, KOHLHASS KL, SORRENTINO R, MURAD F, WARNER TD, VANE JR
(
1992
)
.
INDUCTION OF CALCIUM-INDEPENDENT NITRIC-OXIDE SYNTHASE IN RAT MESENTERY DURING SEPSIS DOES NOT IMPAIR THE VASCULAR-RESPONSE TO VASOCONSTRICTOR AGONISTS
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
107
,
P283
-
P283
.
WARNER TD, SCHMIDT H, MURAD F
(
1992
)
.
INTERACTIONS OF ENDOTHELINS AND EDRF IN BOVINE NATIVE ENDOTHELIAL-CELLS - SELECTIVE EFFECTS OF ENDOTHELIN-3
.
AMERICAN JOURNAL OF PHYSIOLOGY
vol.
262
,
(
5
)
H1600
-
H1605
.
SORRENTINO R, WARNER TD, MITCHELL JA, PINTO A, VANE JR
(
1992
)
.
L-NAME REVEALS AN INCREASED SENSITIVITY TO THE VASOCONSTRICTOR EFFECT OF U46619 IN THE MESENTERIC ARTERIAL AND VENOUS MUSCLES FROM RATS TREATED WITH LPS
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
107
,
P409
-
P409
.
MATSUMOTO T, MITCHELL JA, KOHLHAAS KL, RITGER R, WARNER TD, SCHMIDT H, FORSTEMANN U, MURAD F
(
1992
)
.
LOCALIZATION OF NITRIC-OXIDE SYNTHASE IN FERRET BRAIN
.
FASEB JOURNAL
.
vol.
6
,
A1847
-
A1847
.
CRISTOL JP, WARNER TD, THIEMERMANN C, VANE JR
(
1992
)
.
THE VASOCONSTRICTOR EFFECTS OF ENDOTHELINS AND SARAFOTOXINS IN THE SYSTEMIC CIRCULATION AND RENAL VASCULATURE ARE MEDIATED VIA DIFFERENT RECEPTORS
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
107
,
P278
-
P278
.
Murad F, Forstermann U, Nakane M, Schmidt H, Pollock J, Sheng H, Matsumoto T, Warner T et al.
(
1992
)
.
The nitric oxide-cyclic GMP signal transduction pathway in vascular smooth muscle preparations and other tissues
.
Journal of Pharmacological Sciences
vol.
58
,
(
Molecular Pharmacology 11 1977
)
150
-
157
.
Ishii K, Warner TD, Sheng H, Murad F
(
1991
)
.
Endothelin increases cyclic GMP levels in LLC-PK1 porcine kidney epithelial cells via formation of an endothelium-derived relaxing factor-like substance
.
Journal of Pharmacology and Experimental Therapeutics
vol.
259
,
(
3
)
1102
-
1108
.
Pollock JS, Förstermann U, Mitchell JA, Warner TD, Schmidt HH, Nakane M, Murad F
(
1991
)
.
Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells
.
Proceedings of the National Academy of Sciences of the United States of America
vol.
88
,
(
23
)
10480
-
10484
.
D'Orléans-Juste P, Claing A, Télémaque S, Warner TD, Regoli D
(
1991
)
.
Neurokinins produce selective venoconstriction via NK-3 receptors in the rat mesenteric vascular bed
.
European Journal of Pharmacology
vol.
204
,
(
3
)
329
-
334
.
Förstermann U, Schmidt HHHW, Pollock JS, Sheng H, Mitchell JA, Warner TD, Nakane M, Murad F
(
1991
)
.
Isoforms of nitric oxide synthase Characterization and purification from different cell types
.
Biochemical Pharmacology
vol.
42
,
(
10
)
1849
-
1857
.
Ishii K, Sheng H, Warner TD, Forstermann U, Murad F
(
1991
)
.
A simple and sensitive bioassay method for detection of EDRF with RFL-6 rat lung fibroblasts
.
American Journal of Physiology
vol.
261
,
(
2
)
h598
-
h603
.
Mitchell JA, Förstermann U, Warner TD, Pollock JS, Schmidt HHHW, Heller M, Murad F
(
1991
)
.
Endothelial cells have a particulate enzyme system responsible for EDRF formation: Measurement by vascular relaxation
.
Biochemical and Biophysical Research Communications
vol.
176
,
(
3
)
1417
-
1423
.
Heller M, Förstermann U, Mitchel J, Pollock JS, Schmidt HHHW, Warner T, Murad F
(
1991
)
.
EDRFNO synthesis in bovine aortic endothelial cells: Evidence for soluble and particulate isoenzymes
.
Journal of Molecular and Cellular Cardiology
vol.
23
,
Ishii K, Warner TD, Sheng H, Murad F
(
1991
)
.
Endothelin-1 Stimulates Cyclic GMP Formation in Porcine Kidney Epithelial Cells via Activation of the L-Arginine-Dependent Soluble Guanylate Cyclase Pathway
.
Journal of Cardiovascular Pharmacology
vol.
17
,
s246
-
s250
.
HUANG ZJ, SCHMIDT H, WARNER TD, MITCHELL JA, MURAD F
(
1991
)
.
GLUCOSE-INDUCED FORMATION OF ARGININE-DERIVED NITROGEN-OXIDES FROM HIT-T15 PANCREATIC BETA-CELLS IMPLIES A ROLE OF CYCLIC-GMP IN INSULIN-BIOSYNTHESIS AND OR SECRETION
.
FASEB JOURNAL
.
vol.
5
,
A756
-
A756
.
D'Orléans-Juste P, Lidbury PS, Telemaque S, Warner TD, Vane JR
(
1991
)
.
Human Big Endothelin Releases Prostacyclin in vivo and in vitro Through a Phosphoramidon-Sensitive Conversion to Endothelin-1
.
Journal of Cardiovascular Pharmacology
.
vol.
17
,
s251
-
s255
.
NAKANE M, HARALD, SCHMIDT HHW, WARNER TD, HUANG ZJ, MURAD F
(
1991
)
.
INDUCTION OF TYPE-II GUANYLYL CYCLASE-ACTIVATING-FACTOR (GAF) SYNTHASE IN RAW MACROPHAGES REQUIRES TRANSCRIPTION AND DENOVO-PROTEIN BIOSYNTHESIS
.
FASEB JOURNAL
.
vol.
5
,
A509
-
A509
.
Ishii K, Warner TD, Sheng H, Murad F
(
1991
)
.
O-017 Endothelin increases cyclic GMP levels in LLC-PK1 porcine kidney epithelial cells via formation of an endothelium-derived relaxing factor (EDRF)-like substance
.
Journal of Pharmacological Sciences
vol.
55
,
MITCHELL JA, FORSTERMANN U, WARNER TD, POLLOCK JS, SCHMIDT H, KOHLHAAS KL, HELLER M, MURAD F
(
1991
)
.
PARTICULATE ACTIVITY IS RESPONSIBLE FOR EDRF FORMATION BY NATIVE BOVINE AORTIC ENDOTHELIAL-CELLS
.
FASEB JOURNAL
.
vol.
5
,
A1728
-
A1728
.
WARNER TD, SCHMIDT H, MURAD F
(
1991
)
.
SELECTIVE STIMULATION OF THE RELEASE OF NITROGEN-OXIDES FROM WHOLE BOVINE AORTAE BY ENDOTHELIN-3 BUT NOT ENDOTHELIN-1
.
FASEB JOURNAL
.
vol.
5
,
A1728
-
A1728
.
DILLON T, WARNER TD, SCHMIDT H, BUDZIK GP, OPGENORTH TJ, MURAD F
(
1991
)
.
STIMULATORS OF THE RELEASE OF EDRF DECREASE THE RELEASE OF IMMUNOREACTIVE-ENDOTHELIN FROM WHOLE BOVINE AORTAE
.
FASEB JOURNAL
.
vol.
5
,
A1419
-
A1419
.
Warner TD, D'Orleans-Juste P, Vane JR
(
1990
)
.
Endothelin-1 and U46619 potentiate selectively the venous responses to nerve stimulation within the perfused superior mesenteric vascular bed of the rat
.
Biochemical and Biophysical Research Communications
vol.
172
,
(
2
)
745
-
750
.
D'Orléans-Juste P, Lidbury PS, Warner TD, Vane JR
(
1990
)
.
Intravascular big endothelin increases circulating levels of endothelin-1 and prostanoids in the rabbit
.
Biochemical Pharmacology
vol.
39
,
(
9
)
r21
-
r22
.
DORLEANSJUSTE P, LIDBURY PS, CAPPER SJ, WARNER TD, VANE JR
(
1990
)
.
EXOGENOUS HUMAN BIG-ENDOTHELIN IS CONVERTED TO ENDOTHELIN-1 IN THE RABBIT INVIVO
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
101
,
P510
-
P510
.
Warner TD, Mitchell JA, de Nucci G, Vane JR
(
1989
)
.
Endothelin-1 and Endothelin-3 Release EDRF from Isolated Perfused Arterial Vessels of the Rat and Rabbit
.
Journal of Cardiovascular Pharmacology
vol.
13
,
s85
-
s88
.
Warner TD, de Nucci G, Vane JR
(
1989
)
.
Rat endothelin is a vasodilator in the isolated perfused mesentery of the rat
.
European Journal of Pharmacology
vol.
159
,
(
3
)
325
-
326
.
de Nucci G, Thomas R, D'Orleans-Juste P, Antunes E, Walder C, Warner TD, Vane JR
(
1988
)
.
Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor
.
Proceedings of the National Academy of Sciences of the United States of America
vol.
85
,
(
24
)
9797
-
9800
.
de Nucci G, Gryglewski RJ, Warner TD, Vane JR
(
1988
)
.
Receptor-mediated release of endothelium-derived relaxing factor and prostacyclin from bovine aortic endothelial cells is coupled
.
Proceedings of the National Academy of Sciences of the United States of America
vol.
85
,
(
7
)
2334
-
2338
.
WARNER TD, DENUCCI G, VANE JR
(
1988
)
.
COMPARISON OF THE SURVIVAL OF EDRF AND NITRIC-OXIDE (NO) WITHIN THE ISOLATED PERFUSED MESENTERY OF THE RAT
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
94
,
P335
-
P335
.
DENUCCI G, MITCHELL JA, WARNER TD, BEARPARK T, VANE JR
(
1988
)
.
RELEASE OF EDRF AND PGI2 FROM BAEC INDUCED BY INFUSIONS OF ADP, BRADYKININ, ARACHIDONIC-ACID, L-ARGININE AND ALKALINE BUFFERS
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
95
,
P547
-
P547
.