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Publications:  Prof Ahmad Waseem

Waseem A, Low S, Shah A, Avisetti D(2020). Mutations in SPATA13/ASEF2 cause primary angle closure glaucoma. PLoS Genetics
10.1371/journal.pgen.1008721
https://qmro.qmul.ac.uk/xmlui/handle/123456789/64719
Aldehlawi H, Usman S, Lalli A, Ahmad F, WILLIAMS G, Teh M-T, Waseem A(2020). Serum lipids, retinoic acid and phenol red differentially regulate expression of keratins K1, K10 and K2 in cultured keratinocytes. Scientific Reports vol. 10, (4829)
10.1038/s41598-020-61640-9
https://qmro.qmul.ac.uk/xmlui/handle/123456789/63261
Haider A, Waseem A, Karpukhina N, Mohsin S(2020). Strontium- and Zinc-Containing Bioactive Glass and Alginates Scaffolds. Bioengineering vol. 7, (1)
10.3390/bioengineering7010010
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62542
Teh M-T(2019). Clinical correlation of opposing molecular signatures in head and neck squamous cell carcinoma. BMC Cancer
10.1186/s12885-019-6059-5
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59766
ALDEHLAWI H, Niemiec NA, AVISETTI DR, LALLI A, Teh M-T, WASEEM A(2019). The monoclonal antibody EPR1614Y against the stem cell biomarker keratin K15 lacks specificity and reacts with other keratins. Scientific Reports vol. 9, Article 1943,
10.1038/s41598-018-38163-5
https://qmro.qmul.ac.uk/xmlui/handle/123456789/55344
TEH M(2018). Transcriptome reprogramming by cancer exosomes: identification of novel molecular targets in matrix and immune modulation. Molecular Cancer
10.1186/s12943-018-0846-5
https://qmro.qmul.ac.uk/xmlui/handle/123456789/44023
Maruthappu T, Chikh A, Fell B, Delaney PJ, Brooke MA, Levet C, Moncada-Pazos A, Ishida-Yamamoto A et al.(2017). Rhomboid family member 2 Regulates cytoskeletal stress associated Keratin 16. Nature Communications vol. 8, 14174-14174.
10.1038/ncomms14174
https://qmro.qmul.ac.uk/xmlui/handle/123456789/19007
Nguyen NT, Mackenzie I, Teh M, Waseem A (2015). HOXA7 suppresses keratinocyte differentiation via PKC/AP-1 pathway. MOLECULAR BIOLOGY OF THE CELL. vol. 26,
Brown L, Waseem A, Cruz IN, Szary J, Gunic E, Mannan T, Unadkat M, Yang M et al.(2014). Desmoglein 3 promotes cancer cell migration and invasion by regulating activator protein 1 and protein kinase C-dependent-Ezrin activation. Oncogene vol. 33, (18) 2363-2374.
10.1038/onc.2013.186
Hwang S, Mahadevan S, Qadir F, Hutchison IL, Costea DE, Neppelberg E, Liavaag PG, Waseem A et al.(2013). Identification of FOXM1-induced epigenetic markers for head and neck squamous cell carcinomas. Cancer vol. 119, (24) 4249-4258.
10.1002/cncr.28354
Bose A, Teh M-T, Mackenzie IC, Waseem A(2013). Keratin k15 as a biomarker of epidermal stem cells. Int J Mol Sci vol. 14, (10) 19385-19398.
10.3390/ijms141019385
https://qmro.qmul.ac.uk/xmlui/handle/123456789/18142
Teh M-T, Hutchison IL, Costea DE, Neppelberg E, Liavaag PG, Purdie K, Harwood C, Wan H et al.(2013). Exploiting FOXM1-orchestrated molecular network for early squamous cell carcinoma diagnosis and prognosis. Int J Cancer vol. 132, (9) 2095-2106.
10.1002/ijc.27886
Pitiyage GN, Lim KP, Gemenitzidis E, Teh M-T, Waseem A, Prime SS, Tilakaratne WM, Fortune F et al.(2012). Increased secretion of tissue inhibitors of metalloproteinases 1 and 2 (TIMPs -1 and -2) in fibroblasts are early indicators of oral sub-mucous fibrosis and ageing. J Oral Pathol Med vol. 41, (6) 454-462.
10.1111/j.1600-0714.2012.01129.x
Teh M-T, Gemenetzidis E, Patel D, Tariq R, Nadir A, Bahta AW, Waseem A, Hutchison IL(2012). FOXM1 induces a global methylation signature that mimics the cancer epigenome in head and neck squamous cell carcinoma. PLoS One vol. 7, (3)
10.1371/journal.pone.0034329
https://qmro.qmul.ac.uk/xmlui/handle/123456789/7858
Bose A, Teh M-T, Hutchison IL, Wan H, Leigh IM, Waseem A(2012). Two mechanisms regulate keratin K15 expression in keratinocytes: role of PKC/AP-1 and FOXM1 mediated signalling. PLoS One vol. 7, (6)
10.1371/journal.pone.0038599
https://qmro.qmul.ac.uk/xmlui/handle/123456789/7876
Waseem A, Ali M, Odell EW, Fortune F, Teh M-T(2010). Downstream targets of FOXM1: CEP55 and HELLS are cancer progression markers of head and neck squamous cell carcinoma. Oral Oncol vol. 46, (7) 536-542.
10.1016/j.oraloncology.2010.03.022
https://qmro.qmul.ac.uk/xmlui/handle/123456789/1099
Gemenetzidis E, Elena-Costea D, Parkinson EK, Waseem A, Wan H, Teh MT(2010). Induction of Human Epithelial Stem/Progenitor Expansion by FOXM1. Cancer Research vol. 70, (22) Article N/A, 9515-9526.
10.1158/0008-5472.CAN-10-2173
Gemenetzidis E, Bose A, Riaz AM, Chaplin T, Young BD, Ali M, Sugden D, Thurlow JK et al.(2009). FOXM1 upregulation is an early event in human squamous cell carcinoma and it is enhanced by nicotine during malignant transformation. PLoS One vol. 4, (3)
10.1371/journal.pone.0004849
https://qmro.qmul.ac.uk/xmlui/handle/123456789/11131
Paccione RJ, Miyazaki H, Patel V, Waseem A, Gutkind JS, Zehner ZE, Yeudall WA(2008). Keratin down-regulation in vimentin-positive cancer cells is reversible by vimentin RNA interference, which inhibits growth and motility. Mol Cancer Ther vol. 7, (9) 2894-2903.
10.1158/1535-7163.MCT-08-0450
Teh MT, Tilakaratne WM, Chaplin T, Young BD, Ariyawardana A, Pitiyage G, Lalli A, Stewart JE et al.(2008). Fingerprinting genomic instability in oral submucous fibrosis. J Oral Pathol Med vol. 37, (7) 430-436.
10.1111/j.1600-0714.2008.00643.x
Tilakaratne WM, Iqbal Z, Teh MT, Ariyawardana A, Pitiyage G, Cruchley A, Stewart JE, Hagi-Pavli E et al.(2008). Upregulation of HIF-1alpha in malignant transformation of oral submucous fibrosis. J Oral Pathol Med vol. 37, (6) 372-377.
10.1111/j.1600-0714.2007.00625.x
Lalli A, Tilakaratne WM, Ariyawardana A, Fitchett C, Leigh IM, Hagi-Pavli E, Cruchley AT, Parkinson EK et al.(2008). An altered keratinocyte phenotype in oral submucous fibrosis: correlation of keratin K17 expression with disease severity. J Oral Pathol Med vol. 37, (4) 211-220.
10.1111/j.1600-0714.2007.00609.x
Köse O, Waseem A(2008). Keloids and hypertrophic scars: are they two different sides of the same coin?. Dermatol Surg vol. 34, (3) 336-346.
10.1111/j.1524-4725.2007.34067.x
Kose O, Stewart J, Waseem A, Lalli A, Fortune F(2008). Expression of cytokeratins, adhesion and activation molecules in oral ulcers of Behcet's disease. CLIN EXP DERMATOL vol. 33, (1) 62-69.
10.1111/j.1365-2230.2007.02558.x
Köse O, Lalli A, Kutulola AO, Odell EW, Waseem A(2007). Changes in the expression of stem cell markers in oral lichen planus and hyperkeratotic lesions. J Oral Sci vol. 49, (2) 133-139.
10.2334/josnusd.49.133
Tilakaratne W, Iqball Z, Teh MT, Ariyawardana A, Pitiyage G, Cruchley A, Hagi-Pavli E, Lalli A et al. (2007). Up regulation of HIF-1 alpha in the progression and malignant transformation of oral submucous fibrosis. ORAL ONCOLOGY. vol. 2, 204-205.
WASEEM A(2006). The skin. Embryos, Genes and Birth Defects, Editors: Ferretti, P, Copp, A, Tickle, C, Moore, G et al., Wiley
Radoja N, Stojadinovic O, Waseem A, Tomic-Canic M, Milisavljevic V, Teebor S, Blumenberg M(2004). Thyroid hormones and gamma interferon specifically increase K15 keratin gene transcription. Mol Cell Biol vol. 24, (8) 3168-3179.
10.1128/mcb.24.8.3168-3179.2004
Waseem A, Karsten U, Leigh IM, Purkis P, Waseem NH, Lane EB(2004). Conformational changes in the rod domain of human keratin 8 following heterotypic association with keratin 18 and its implication for filament stability. Biochemistry vol. 43, (5) 1283-1295.
10.1021/bi035072s
Bowen SL, Bloor BK, Leigh IM, Waseem A(2003). Adducin expression in cutaneous and oral lesions: alpha- and beta-adducin transcripts down-regulate with keratinocyte differentiation in stratified epithelia. J Pathol vol. 201, (1) 119-126.
10.1002/path.1389
Bloor BK, Tidman N, Leigh IM, Odell E, Dogan B, Wollina U, Ghali L, Waseem A(2003). Expression of keratin K2e in cutaneous and oral lesions: association with keratinocyte activation, proliferation, and keratinization. Am J Pathol vol. 162, (3) 963-975.
10.1016/S0002-9440(10)63891-6
Ditzel HJ, Strik MCM, Larsen MK, Willis AC, Waseem A, Kejling K, Jensenius JC(2002). Cancer-associated cleavage of cytokeratin 8/18 heterotypic complexes exposes a neoepitope in human adenocarcinomas. J Biol Chem vol. 277, (24) 21712-21722.
10.1074/jbc.M202140200
Ola A, Waga S, Ellison V, Stillman B, McGurk M, Leigh IM, Waseem NH, Waseem A(2001). Human-Saccharomyces cerevisiae proliferating cell nuclear antigen hybrids: oligomeric structure and functional characterization using in vitro DNA replication. J Biol Chem vol. 276, (13) 10168-10177.
10.1074/jbc.M008929200
Waseem A, Alam Y, Dogan B, White KN, Leigh IM, Waseem NH(1998). Erratum: Isolation, sequence and expression of the gene encoding human keratin 13 (Gene (1998) 215 (269-279) PII: S0378111997002972). Gene vol. 221, (2)
10.1016/S0378-1119(98)00481-8
Waseem A, Alam Y, Dogan B, White KN, Leigh IM, Waseem NH(1998). Isolation, sequence and expression of the gene encoding human keratin 13. Gene vol. 215, (2) 269-279.
10.1016/S0378-1119(98)00297-2
Waseem A, White K, Waseem NH(1997). Identification of a novel keratin epitope: Evidence for association between non-helical sub-domains L12 during filament assembly. International Journal of Biochemistry and Cell Biology vol. 29, (7) 971-983.
10.1016/S1357-2725(97)00055-1
Waseem A, Lane EB, Harrison D, Waseem N(1996). A keratin antibody recognizing a heterotypic complex: Epitope mapping to complementary locations on both components of the complex. Experimental Cell Research vol. 223, (2) 203-214.
10.1006/excr.1996.0074
Waseem A, Salahuddin A(1983). Anomalous temperature-dependence of the specific interaction of concanavalin A with a multivalent ligand-dextran. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology vol. 746, (1-2) 65-71.
10.1016/0167-4838(83)90011-0
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