Publications:  Dr Muy-Teck Teh

Garcia Gonzalez J, Brock A, Parker M, Riley R, Joliffe D, SUDWARTS A, Teh M-T, Busch-Nentwich E et al.(2020). Identification of Slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour. eLife

Aldehlawi H, Usman S, Lalli A, Ahmad F, WILLIAMS G, Teh M-T, Waseem A(2020). Serum lipids, retinoic acid and phenol red differentially regulate expression of keratins K1, K10 and K2 in cultured keratinocytes. Scientific Reports vol. 10, (4829)

Teh M-T(2019). The transcription factor FOXM1 regulates the balance between proliferation and aberrant differentiation in head and neck squamous cell carcinoma. Journal of Pathology

Uttagomol J, Ahmad US, Rehman A, Huang Y, Laly AC, Kang A, Soetaert J, Chance R et al.(2019). Evidence for the desmosomal cadherin desmoglein-3 in regulating YAP and Phospho-YAP in keratinocyte responses to mechanical forces. International Journal of Molecular Sciences vol. 20, (24)

Rehman A, Cai Y, Hünefeld C, Jedli¿ková H, Huang Y, Teck Teh M, Sharif Ahmad U, Uttagomol J et al.(2019). The desmosomal cadherin desmoglein-3 acts as a keratinocyte anti-stress protein via suppression of p53. Cell Death and Disease vol. 10, (10)

Teh M-T(2019). Clinical correlation of opposing molecular signatures in head and neck squamous cell carcinoma. BMC Cancer

ALDEHLAWI H, Niemiec NA, AVISETTI DR, LALLI A, Teh M-T, WASEEM A(2019). The monoclonal antibody EPR1614Y against the stem cell biomarker keratin K15 lacks specificity and reacts with other keratins. Scientific Reports vol. 9, Article 1943,

TEH M(2018). Transcriptome reprogramming by cancer exosomes: identification of novel molecular targets in matrix and immune modulation. Molecular Cancer

Pantazi E, Gemenetzidis E, Teh MT, Reddy SV, Warnes G, Evagora C, Trigiante G, Philpott MP(2017). GLI2 Is a Regulator of β-Catenin and Is Associated with Loss of E-Cadherin, Cell Invasiveness, and Long-Term Epidermal Regeneration. Journal of Investigative Dermatology vol. 137, (8) 1719-1730.

Parajuli H, Teh MT, Abrahamsen S, Christoffersen I, Neppelberg E, Lybak S, Osman T, Johannessen AC et al.(2016). Integrin α11 is overexpressed by tumour stroma of head and neck squamous cell carcinoma and correlates positively with alpha smooth muscle actin expression. J Oral Pathol Med

TEH M, Wan HONG(2016). Independent Evaluation of a FOXM1-based Quantitative Malignancy Diagnostic System (qMIDS) on Head and Neck Squamous Cell Carcinomas. Oncotarget vol. 7, (34) 54555-54563.

TEH M(2016). Oral Cancer Biomarkers: Is it a Meaningless Game?. Dentistry Open Journal vol. 3, (1) Article 1, e1-e3.

Sapkota D, Bruland O, Parajuli H, Osman T, Teh MT, Johannessen A, Costea D (2016). S100A16 Functions as a Tumor Suppressor Protein in Oral Squamous Cell Carcinoma. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. vol. 94, 944-945.

Parker MO, Brock AJ, Sudwarts A, Teh MT, Combe FJ, Brennan CH(2015). Developmental role of acetylcholinesterase in impulse control in zebrafish. Frontiers in Behavioral Neuroscience vol. 9, (OCTOBER)

Sapkota D, Bruland O, Parajuli H, Osman TA, Teh M-T, Johannessen AC, Costea DE(2015). S100A16 promotes differentiation and contributes to a less aggressive tumor phenotype in oral squamous cell carcinoma. BMC Cancer vol. 15,

TEH M(2015). Is Salivary Exosome the Answer to Early Detection of Oral Cancer?. Dentistry Open Journal vol. 2, (2) e3-e4.

Teh M-T(2015). Can Challenges of Oral Cancer Diagnosis be Resolved?. Dental Health: Current Research vol. 01, (01)

Nguyen NT, Mackenzie I, Teh M, Waseem A (2015). HOXA7 suppresses keratinocyte differentiation via PKC/AP-1 pathway. MOLECULAR BIOLOGY OF THE CELL. vol. 26,

Parker MO, Annan LV, Kanellopoulos AH, Brock AJ, Combe FJ, Baiamonte M, Teh MT, Brennan CH(2014). The utility of zebrafish to study the mechanisms by which ethanol affects social behavior and anxiety during early brain development. Progress in Neuro-Psychopharmacology and Biological Psychiatry vol. 55, 94-100.

Parker MO, Evans AMD, Brock AJ, Combe FJ, Teh MT, Brennan CH(2014). Moderate alcohol exposure during early brain development increases stimulus-response habits in adulthood. Addiction Biology

Pantazi E, Gemenetzidis E, Trigiante G, Warnes G, Shan L, Mao X, Ikram M, Teh M-T et al.(2014). GLI2 induces genomic instability in human keratinocytes by inhibiting apoptosis. Cell Death Dis vol. 5,

Pantazi E, Gemenetzidis E, Trigiante G, Warnes G, Shan L, Mao X, Ikram M, Teh MT et al. (2014). GLI2 induces genomic instability in human keratinocytes by inhibiting apoptosis. Cell death & disease. vol. 5,

Parker MO, Annan LV, Kanellopoulos AH, Brock AJ, Combe FJ, Baiamonte M, Teh M-T, Brennan CH(2014). The utility of zebrafish to study the mechanisms by which ethanol affects social behavior and anxiety during early brain development. Progress in Neuro-Psychopharmacology and Biological Psychiatry

Hwang S, Mahadevan S, Qadir F, Hutchison IL, Costea DE, Neppelberg E, Liavaag PG, Waseem A et al.(2013). Identification of FOXM1-induced epigenetic markers for head and neck squamous cell carcinomas. Cancer vol. 119, (24) 4249-4258.

Bose A, Teh M-T, Mackenzie IC, Waseem A(2013). Keratin k15 as a biomarker of epidermal stem cells. Int J Mol Sci vol. 14, (10) 19385-19398.

Teh M-T, Hutchison IL, Costea DE, Neppelberg E, Liavaag PG, Purdie K, Harwood C, Wan H et al.(2013). Exploiting FOXM1-orchestrated molecular network for early squamous cell carcinoma diagnosis and prognosis. Int J Cancer vol. 132, (9) 2095-2106.

Teh M-T(2012). Cells brainwashed by FOXM1: do they have potential as biomarkers of cancer?. Biomark Med vol. 6, (4) 499-501.

Pitiyage GN, Lim KP, Gemenitzidis E, Teh MT, Waseem A, Prime SS, Tilakaratne WM, Fortune F et al.(2012). Increased secretion of tissue inhibitors of metalloproteinases 1 and 2 (TIMPs -1 and -2) in fibroblasts are early indictors of oral sub-mucous fibrosis and ageing. Journal of Oral Pathology and Medicine vol. 41, (6) 454-462.

Teh MT (2012). Methods for Diagnosing Cancer. no. PCT/GB2011/001130,

Teh M-T(2012). FOXM1 coming of age: time for translation into clinical benefits?. Front Oncol vol. 2,

Teh M-T, Gemenetzidis E, Patel D, Tariq R, Nadir A, Bahta AW, Waseem A, Hutchison IL(2012). FOXM1 induces a global methylation signature that mimics the cancer epigenome in head and neck squamous cell carcinoma. PLoS One vol. 7, (3)

Bose A, Teh M-T, Hutchison IL, Wan H, Leigh IM, Waseem A(2012). Two mechanisms regulate keratin K15 expression in keratinocytes: role of PKC/AP-1 and FOXM1 mediated signalling. PLoS One vol. 7, (6)

TEH M(2011). Chapter 14: Initiation of Human Tumourigenesis: Upregulation of FOXM1 Transcription Factor. Stem Cells and Cancer Stem Cells,Volume 3, Editors: Hayat, MA, Springer Verlag

Teh M-T, Parkinson EK, Thurlow JK, Liu F, Fortune F, Wan H(2011). A molecular study of desmosomes identifies a desmoglein isoform switch in head and neck squamous cell carcinoma. J Oral Pathol Med vol. 40, (1) 67-76.

Gemenetzidis E, Costea DE, Parkinson EK, Waseem A, Wan H, Teh MT(2010). Induction of Human Epithelial Stem/Progenitor Expansion by FOXM1. Cancer Research vol. 22, (70) 9515-9526.

Waseem A, Ali M, Odell EW, Fortune F, Teh M-T(2010). Downstream targets of FOXM1: CEP55 and HELLS are cancer progression markers of head and neck squamous cell carcinoma. Oral Oncol vol. 46, (7) 536-542.

Wang HX, Teh MT, Ji YM, Patel V, Firouzabadian S, Patel AA, Gutkind JS, Yeudall WA(2010). EPS8 upregulates FOXM1 expression, enhancing cell growth and motility. CARCINOGENESIS vol. 31, (6) 1132-1141.

Tsang S, Liu L, Teh M, Wheeler A, Piper K, Grose R, Hart I, Garrod D et al. (2010). Novel role for human desmoglein 3 in regulating E-cadherin mediated adherens junctions through Src family kinase activation. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 130, S33-S33.

Pantazi E, Trigiante G, Warnes G, Gemenetzidis E, Teh MT, Ikram M, Shan L, Lu YJ et al. (2010). Overexpression of GLI2 in human keratinocytes results in resistance to ultraviolet B-induced apoptosis and increased chromosomal instability. BRITISH JOURNAL OF DERMATOLOGY. vol. 162, 948-948.

Teh M-T, Gemenetzidis E, Chaplin T, Young BD, Philpott MP(2010). Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes. Mol Cancer vol. 9,

Tsang SM, Liu L, Teh M-T, Wheeler A, Grose R, Hart IR, Garrod DR, Fortune F et al.(2010). Desmoglein 3, via an interaction with E-cadherin, is associated with activation of Src. PloS ONE vol. 5, (12)

Gemenetzidis E, Elena-Costea D, Parkinson EK, Waseem A, Wan H, Teh MT(2010). Induction of Human Epithelial Stem/Progenitor Expansion by FOXM1. Cancer Research vol. 70, (22) Article N/A, 9515-9526.

Pantazi E, Trigianti G, Warnes G, Gemenetzidis E, Teh MT, Philpott MP (2009). Overexpression of GLI2 in human keratinocytes results in polyploidy and resistance to ultraviolet B-induced apoptosis. BRITISH JOURNAL OF DERMATOLOGY. vol. 160, 908-908.

Gemenetzidis E, Bose A, Riaz AM, Chaplin T, Young BD, Ali M, Sugden D, Thurlow JK et al.(2009). FOXM1 upregulation is an early event in human squamous cell carcinoma and it is enhanced by nicotine during malignant transformation. PLoS One vol. 4, (3)

Teh MT, Tilakaratne WM, Chaplin T, Young BD, Ariyawardana A, Pitiyage G, Lalli A, Stewart JE et al.(2008). Fingerprinting genomic instability in oral submucous fibrosis. J Oral Pathol Med vol. 37, (7) 430-436.

Tilakaratne WM, Iqbal Z, Teh MT, Ariyawardana A, Pitiyage G, Cruchley A, Stewart JE, Hagi-Pavli E et al.(2008). Upregulation of HIF-1 alpha in malignant transformation of oral submucous fibrosis. J ORAL PATHOL MED vol. 37, (6) 372-377.

Lalli A, Tilakaratne WM, Ariyawardana A, Fitchett C, Leigh IM, Hagi-Pavli E, Cruchley AT, Parkinson EK et al.(2008). An altered keratinocyte phenotype in oral submucous fibrosis: correlation of keratin K17 expression with disease severity. J ORAL PATHOL MED vol. 37, (4) 211-220.

Faust R, Garratt PJ, Perez MAT, Piccio VJD, Madsen C, Stenstrom A, Frolund B, Davidson K et al.(2007). 7-Substituted-melatonin and 7-substituted-1-methylmelatonin analogues: Effect of substituents on potency and binding affinity. BIOORGAN MED CHEM vol. 15, (13) 4543-4551.

Purdie KJ, Lambert SR, Teh M-T, Chaplin T, Molloy G, Raghavan M, Kelsell DP, Leigh IM et al.(2007). Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis. Genes Chromosomes Cancer vol. 46, (7) 661-669.

Purdie K, Lambert S, Teh M, Chaplin T, Molloy G, Raghavan M, Kelsell DP, Leigh IM et al. (2007). Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis. BRITISH JOURNAL OF DERMATOLOGY. vol. 156, 1100-1101.

Tilakaratne W, Iqball Z, Teh MT, Ariyawardana A, Pitiyage G, Cruchley A, Hagi-Pavli E, Lalli A et al. (2007). Up regulation of HIF-1 alpha in the progression and malignant transformation of oral submucous fibrosis. ORAL ONCOLOGY. vol. 2, 204-205.

Teh MT, Blaydon D, Ghali LR, Briggs V, Edmunds S, Pantazi E, Barnes MR, Leigh IM et al.(2007). Erratum: Role for WNT16B in human epidermal keratinocyte proliferation and differentiation (Journal of Cell Science vol. 120 (330-339)). Journal of Cell Science vol. 120, (5)

Teh MT, Blaydon D, Ghali LR, Briggs V, Edmunds S, Pantazi E, Barnes MR, Leigh IM et al.(2007). Role for WNT16B in human epidermal keratinocyte proliferation and differentiation (vol 120, pg 330, 2007). J CELL SCI vol. 120, (5) 917-917.

Teh M-T, Blaydon D, Ghali LR, Briggs V, Edmunds S, Pantazi E, Barnes MR, Leigh IM et al.(2007). Role for WNT16B in human epidermal keratinocyte proliferation and differentiation. J Cell Sci vol. 120, (Pt 2) 330-339.

Blaydon DC, Ishii Y, O'Toole EA, Unsworth HC, Teh M-T, Rüschendorf F, Sinclair C, Hopsu-Havu VK et al.(2006). The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia. Nat Genet vol. 38, (11) 1245-1247.

Blaydon DC, Ishii Y, O'Toole EA, Teh MT, Hopsu-Havu VK, Moss C, Ruschendorf F, Wajid M et al. (2006). R-spondin 4 (RSPO4), a novel secreted protein implicated in Wnt signalling, is mutated in inherited anonychia. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 126, 31-31.

Tsotinis A, Vlachou M, Papahatjis DP, Calogeropoulou T, Nikas SP, Garratt PJ, Piccio V, Vonhoff S et al.(2006). Mapping the melatonin receptor. 7. Subtype selective ligands based on beta-substituted N-acyl-5-methoxytryptamines and beta-substituted N-acyl-5-methoxy-1-methyltryptamines. J MED CHEM vol. 49, (12) 3509-3519.

Purdie K, Teh M, Harwood C, Young B, Proby C, Leigh I (2006). Allelic imbalances and chromosome 9p microdeletion demonstrated in cutaneous squamous cell carcinomas using single nucleotide polymorphism microarray analysis. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 126, 18-18.

Teh M-T, Blaydon D, Chaplin T, Foot NJ, Skoulakis S, Raghavan M, Harwood CA, Proby CM et al.(2005). Genomewide single nucleotide polymorphism microarray mapping in basal cell carcinomas unveils uniparental disomy as a key somatic event. Cancer Res vol. 65, (19) 8597-8603.

Kelsell DP, Norgett EE, Unsworth H, Teh MT, Cullup T, Mein CA, Dopping-Hepenstal PJ, Kennedy CT et al. (2005). Clinical and molecular features of Harlequin ichthyosis. BRITISH JOURNAL OF DERMATOLOGY. vol. 153, 5-5.

Kelsell DP, Norgett EE, Unsworth H, Teh M-T, Cullup T, Mein CA, Dopping-Hepenstal PJ, Dale BA et al.(2005). Mutations in ABCA12 underlie the severe congenital skin disease harlequin ichthyosis. Am J Hum Genet vol. 76, (5) 794-803.

Teh M, Quinn AG, Philpott MP (2005). FOXM1b activates DNA repair and suppresses UVB-induced apoptosis in human keratinocytes. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 124, A17-A17.

Blaydon DC, Teh M, Foot NJ, Philpott MP, Harwood C, Proby C, Young BD, Kelsell DP (2005). Genome-wide SNP microarray mapping in basal cell carcinomas unveils uniparental dismay as a key somatic event. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 124, A20-A20.

Kelsell DP, Norgett E, Unsworth H, Teh M, Cullop T, Dale B, Leigh IM, Eady RA et al. (2005). Mutations in ABCA12 underlie harlequin ichthyosis. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 124, A75-A75.

Teh MT, Quinn AG, Philpott MP (2005). The Human forkhead transcription factor FOXM1B enhances DNA repair and suppresses UVB-induced apoptosis. BRITISH JOURNAL OF DERMATOLOGY. vol. 152, 842-843.

Sugden D, Davidson K, Hough KA, Teh M-T(2004). Melatonin, melatonin receptors and melanophores: a moving story. Pigment Cell Res vol. 17, (5) 454-460.

Davies DJ, Faust R, Garratt PJ, Marivingt-Mounir C, Davidson K, Teh MT, Sugden D(2004). Binding affinity and biological activity of oxygen and sulfur isosteres at melatonin receptors as a function of their hydrogen bonding capability. BIOORG CHEM vol. 32, (1) 1-12.

Teh M-T, Wong S-T, Neill GW, Ghali LR, Philpott MP, Quinn AG(2002). FOXM1 is a downstream target of Gli1 in basal cell carcinomas. Cancer Res vol. 62, (16) 4773-4780.

Teh M-T, Sugden D(2002). Desensitization of pigment granule aggregation in Xenopus leavis melanophores: melatonin degradation rather than receptor down-regulation is responsible. J Neurochem vol. 81, (4) 719-727.

Teh MT, Sugden D(2001). An endogenous 5-HT7 receptor mediates pigment granule dispersion in Xenopus laevis melanophores. BRIT J PHARMACOL vol. 132, (8) 1799-1808.

Teh MT (2000). Cellular and Molecular Studies on Pigment-Granule Translocation in Xenopus Melanophores. Supervisors: Sugden, DD, Presented at: King's College, University of London,

Faust R, Garratt PJ, Jones R, Yeh LK, Tsotinis A, Panoussopoulou M, Calogeropoulou T, Teh MT et al.(2000). Mapping the melatonin receptor. 6. Melatonin agonists and antagonists derived from 6H-isoindolo[2,1-a]indoles, 5,6-dihydroindolo[2,1-a]isoquinolines, and 6,7-dihydro-5H-benzo[c]azepino[2,1-a]indoles. J MED CHEM vol. 43, (6) 1050-1061.

Li PK, Sugden D, Teh MT, Chu GH, Witt-Enderby PA(1999). Synthesis and studies of irreversible melatonin receptor ligands. ABSTR PAP AM CHEM S vol. 218, U962-U962.

Sugden D, Yeh LK, Teh MT (1999). Design of subtype selective melatonin receptor agonists and antagonists. REPRODUCTION NUTRITION DEVELOPMENT. vol. 39, 335-344.

Teh MT, Sugden D(1999). The putative melatonin receptor antagonist GR128107 is a partial agonist on Xenopus laevis melanophores. BRIT J PHARMACOL vol. 126, (5) 1237-1245.

Teh MT, Sugden D(1998). GR128107 is a partial melatonin receptor agonist on Xenopus laevis melanophores. BRIT J PHARMACOL vol. 125, U39-U39.

Teh MT, Sugden D(1998). Comparison of the structure-activity relationships of melatonin receptor agonists and antagonists: Lengthening the N-acyl side-chain has differing effects on potency on Xenopus melanophores. N-S ARCH PHARMACOL vol. 358, (5) 522-528.

Davies DJ, Garratt PJ, Tocher DA, Vonhoff S, Davies J, Teh MT, Sugden D(1998). Mapping the melatonin receptor. 5. Melatonin agonists and antagonists derived from tetrahydrocyclopent[b]indoles, tetrahydrocarbazoles and hexahydrocyclohept[b]indoles. J MED CHEM vol. 41, (4) 451-467.

Sugden D, Pickering H, Teh MT, Garratt PJ (1997). Melatonin receptor pharmacology: toward subtype specificity. BIOLOGY OF THE CELL. vol. 89, 531-537.