Publications:  Prof Denise Sheer

Dumas A, Pomella N, Rosser G, Guglielmi L, Vinel C, Millner T, Rees J, Aley N et al.(2020). Microglia promote glioblastoma via mTOR-mediated immunosuppression of the tumour microenvironment. The EMBO Journal

Merve A, Zhang X, Pomella N, Acquati S, Hoeck JD, Dumas A, Rosser G, Li Y et al.(2019). Correction to: C-MYC overexpression induces choroid plexus papillomas through a T-cell mediated inflammatory mechanism (Acta Neuropathologica Communications (2019) 7:95 DOI: 10.1186/s40478-019-0739-x). Acta Neuropathologica Communications vol. 7, (1)

Merve A, Zhang X, Pomella N, Acquati S, Hoeck J, Dumas A, Rosser G, Li Y et al. (2019). CHOROID PLEXUS PAPILLOMAS ARE INDUCED BY C-MYC OVEREXPRESSION IN THE CHOROID PLEXUS VIA A T-CELL INFLAMMATORY MECHANISM. NEURO-ONCOLOGY. vol. 21, 9-9.

Caley M, Marsh S, Martins VL, Corbett-Jones T, Chen M, Di W, Sheer D, McGrath JA et al. (2019). Defective DNA Repair and Chromosomal Instability in RDEB. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 139, S265-S265.

Marsh S, Caley MP, Martins VLC, Corbett-Jones T, Chen M, Di W, Sheer D, McGrath JA et al. (2019). Type VII collagen and Nesprin 2: LINCing the basement membrane to altered cell cycle and increased DNA damage. BRITISH JOURNAL OF DERMATOLOGY. vol. 180, E188-E189.

Merve A, Zhang X, Pomella N, Acquati S, Hoeck JD, Dumas A, Rosser G, Li Y et al.(2019). C-MYC overexpression induces choroid plexus papillomas through a T-cell mediated inflammatory mechanism. Acta Neuropathologica Communications vol. 7, (1)

Adiutori R, Aarum J, Zubiri I, Bremang M, Jung S, Sheer D, Pike I, Malaspina A(2018). The proteome of neurofilament-containing protein aggregates in blood. Biochemistry and Biophysics Reports vol. 14, 168-177.

Jeyapalan JN, Doctor GT, Jones TA, Alberman SN, Tep A, Haria CM, Schwalbe EC, Morley ICF et al.(2016). DNA methylation analysis of paediatric low-grade astrocytomas identifies a tumour-specific hypomethylation signature in pilocytic astrocytomas. Acta Neuropathologica Communications vol. 4, (1)

Noor DAM, Jeyapalan JN, Alhazmi S, Carr M, Squibb B, Wallace C, Tan C, Cusack M et al.(2016). Genome-wide methylation analysis identifies genes silenced in non-seminoma cell lines. NPJ Genom Med vol. 1,

Jones TA, Jeyapalan JN, Forshew T, Tatevossian RG, Lawson ARJ, Patel SN, Doctor GT, Mumin MA et al.(2015). Molecular analysis of pediatric brain tumors identifies microRNAs in pilocytic astrocytomas that target the MAPK and NF-κB pathways. Acta neuropathologica communications vol. 3,

Sheer D, Jeyapalan J, Doctor GT, Jones TA, Alberman SN, Tep A, Haria CM, Schwalbe EC et al.(2015). DNA METHYLATION ANALYSIS OF PAEDIATRIC LOW-GRADE ASTROCYTOMAS IDENTIFIES A TUMOUR-SPECIFIC SIGNATURE AT A SET OF ENHANCERS. PEDIATRIC BLOOD & CANCER vol. 62, S283-S284.

Jeyapalan JN, Haria CM, Jones TA, Tatevossian RG, Qaddoumi I, Ellison DW, Sheer D (2015). EXPRESSION OF THE ONCOGENIC SPLICE VARIANT OF CYCLIN D1, CCND1B, IN PAEDIATRIC LOW GRADE GLIOMAS. NEURO-ONCOLOGY. vol. 17, 14-14.

Coll-Bastus N, Mao X, Young BD, Sheer D, Lu Y-J(2015). DNA replication-dependent induction of gene proximity by androgen. Hum Mol Genet vol. 24, (4) 963-971.

Jeyapalan JN, Jones TA, Tatevossian RG, Qaddoumi I, Ellison D, Sheer D (2014). MICRORNA PROFILING USING SMALL RNA-SEQ IN PAEDIATRIC LOW GRADE GLIOMAS. NEURO-ONCOLOGY. vol. 16,

Ottaviani D, LeCain M, Sheer D(2014). The role of microhomology in genomic structural variation. Trends Genet vol. 30, (3) 85-94.

Bastus NC, Mao X, Young BD, Sheer D, Lu Y-J(2014). Novel function of androgen receptor-the regulation of DNA replication and genomic movement. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE vol. 34, S89-S89.

Ogunkolade BW, Jones TA, Aarum J, Szary J, Owen N, Ottaviani D, Mumin MA, Patel S et al.(2013). BORIS/CTCFL is an RNA-binding protein that associates with polysomes. BMC Cell Biol vol. 14,

Henriquez NV, Forshew T, Tatevossian R, Ellis M, Richard-Loendt A, Rogers H, Jacques TS, Reitboeck PG et al.(2013). Comparative expression analysis reveals lineage relationships between human and murine gliomas and a dominance of glial signatures during tumor propagation in vitro. Cancer Res vol. 73, (18) 5834-5844.

Zhang J, Wu G, Miller CP, Tatevossian RG, Dalton JD, Tang B, Orisme W, Punchihewa C et al.(2013). Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas. Nature Genetics vol. 45, (6) 602-612.

Forshew T, Lewis P, Waldman A, Peterson D, Glaser M, Brock C, Sheer D, Mulholland PJ(2013). Three different brain tumours evolving from a common origin. Oncogenesis vol. 2,

Jeyapalan JN, Patel SN, Forshew T, Lawson ARJ, Tatevossian RG, Corbett-Jones T, Mumin MA, Picker SR et al.(2012). MICRORNA SIGNATURES IN A BROAD COHORT OF PAEDIATRIC BRAIN TUMOURS. PEDIATRIC BLOOD & CANCER vol. 59, (6) 1084-1084.

Jeyapalan JN, Morley ICF, Hill AA, Mumin MA, Tatevossian RG, Qaddoumi I, Ellison DW, Sheer D (2012). DNA METHYLATION PROFILING OF LOW GRADE ASTROCYTOMAS USING THE ILLUMINA 450K BEADCHIP REVEALS CHANGES IN GENES INVOLVED IN BRAIN DEVELOPMENT AND DRUG RESISTANCE. NEURO-ONCOLOGY. vol. 14, 3-3.

Ottaviani D, Lever E, Mao S, Christova R, Ogunkolade BW, Jones TA, Szary J, Aarum J et al.(2012). CTCF binds to sites in the major histocompatibility complex that are rapidly reconfigured in response to interferon-gamma. Nucleic Acids Res vol. 40, (12) 5262-5270.

Jeyapalan JN, Morley ICF, Hill AA, Tatevossian RG, Qaddoumi I, Ellison D, Sheer D (2012). DNA METHYLATION PROFILING OF LOW GRADE ASTROCYTOMAS USING THE ILLUMINA 450K BEADCHIP REVEALS CHANGES IN GENES INVOLVED IN BRAIN DEVELOPMENT AND DRUG RESISTANCE. NEURO-ONCOLOGY. vol. 14, 77-77.

Viana-Pereira M, Pereira M, Burford A, Jury A, Popov S, Perryman L, Bax D, Forshew T et al. (2012). MOLECULAR DETERMINANTS OF EFFICACY OF MET RECEPTOR INHIBITION IN PAEDIATRIC GLIOBLASTOMA. NEURO-ONCOLOGY. vol. 14, 66-67.

Tatevossian R, Qaddoumi I, Tang B, Dalton J, Shurtleff S, Punchihewa C, Orisme W, Neale G et al. (2012). RAF GENE ABNORMALITIES DEFINE SUBSETS OF PEDIATRIC LOW-GRADE GLIOMAS AND GLIONEURONAL TUMORS. NEURO-ONCOLOGY. vol. 14, 77-78.

Ellison D, Tatevossian R, Qaddoumi I, Tang B, Dalton J, Shurtleff S, Punchihewa C, Orisme W et al. (2012). RAF Gene Abnormalities Define Subsets of Pediatric Low-Grade Gliomas and Glioneuronal Tumors. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. vol. 71, 577-577.

Nicolaides T, Hariono S, Barkovich K, Hashizume R, Rowitch D, Weiss W, Sheer D, Baker S et al.(2011). TARGETED THERAPY FOR BRAFV600E MUTANT MALIGNANT ASTROCYTOMA. NEURO-ONCOLOGY vol. 13, 112-112.

Bezecny P, Sang NJPXWF, Mumin MA, Pieri C, Mulholland PJ, Sheer D (2011). Addition of Erlotinib Changes Gene Expression in Glioblastoma Cell Lines Treated With Vorinostat. EUROPEAN JOURNAL OF CANCER. vol. 47, S578-S578.

Hashizume R, Aoki Y, Hariono S, Huillard E, Rowitch D, Jones C, Forshew T, Sheer D et al. (2011). COMBINATION-TARGETED THERAPY SHOWS IMPROVED EFFICACY AGAINST BRAF(V600E) MUTANT MALIGNANT ASTROCYTOMAS. NEURO-ONCOLOGY. vol. 13, I1-I1.

Tatevossian R, Tang B, Dalton J, Forshew T, Lawson A, Ma J, Neale G, Shurtleff S et al. (2011). MYB UPREGULATION AND GENETIC ABERRATIONS IN A SUBSET OF PEDIATRIC LOW-GRADE GLIOMAS. NEURO-ONCOLOGY. vol. 13, I5-I5.

Lawson ARJ, Hindley GFL, Forshew T, Tatevossian RG, Jamie GA, Kelly GP, Neale GA, Ma J et al. (2011). RAF GENE FUSION BREAKPOINTS IN PEDIATRIC BRAIN TUMORS ARE CHARACTERIZED BY SIGNIFICANT ENRICHMENT OF SEQUENCE MICROHOMOLOGY. NEURO-ONCOLOGY. vol. 13, I24-I25.

Lawson ARJ, Hindley GFL, Forshew T, Tatevossian RG, Jamie GA, Kelly GP, Neale GA, Ma J et al.(2011). RAF gene fusion breakpoints in pediatric brain tumors are characterized by significant enrichment of sequence microhomology. Genome Res vol. 21, (4) 505-514.

Jeyapalan JN, Mumin MA, Forshew T, Lawson ARJ, Tatevossian RG, Jacques TS, Sheer D (2011). MICRORNA EXPRESSION IN PAEDIATRIC BRAIN TUMOURS. NEURO-ONCOLOGY. vol. 13, 6-6.

Jones TA, Ogunkolade BW, Szary J, Aarum J, Mumin MA, Patel S, Pieri CA, Sheer D(2011). Widespread expression of BORIS/CTCFL in normal and cancer cells. PLoS One vol. 6, (7)

Tatevossian RG, Tang B, Dalton J, Forshew T, Lawson AR, Ma J, Neale G, Shurtleff SA et al.(2010). MYB upregulation and genetic aberrations in a subset of pediatric low-grade gliomas. ACTA NEUROPATHOL vol. 120, (6) 731-743.

Tatevossian R, Tang B, Forshew T, Lawson A, Dalton J, Ma J, Neale G, Broniscer A et al.(2010). DNA COPY NUMBER CHANGES AND KIAA1549-BRAF FUSION GENE DETECTION IN 125 PEDIATRIC LOW-GRADE GLIOMAS. PEDIATR BLOOD CANCER vol. 55, (5) 798-799.

Bezecny P, Pieri C, Szary J, Mulholland PJ, Sheer D (2010). HISTONE DEACETYLASE INHIBITOR VORINOSTAT REDUCES EXPRESSION OF PLATELET-DERIVED GROWTH FACTOR RECEPTOR A (PDGFRA) AND MATRIX METALLOPROTEINASE-2 (MMP2) GENES IN GLIOBLASTOMA CELL LINES. ANNALS OF ONCOLOGY. vol. 21, 333-334.

Lawson ARJ, Tatevossian RG, Phipps KP, Picker SR, Michalski A, Sheer D, Jacques TS, Forshew T(2010). RAF gene fusions are specific to pilocytic astrocytoma in a broad paediatric brain tumour cohort. Acta Neuropathol vol. 120, (2) 271-273.

Reynolds LE, Watson AR, Baker M, Jones TA, D'Amico G, Robinson SD, Joffre C, Garrido-Urbani S et al.(2010). Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome (Corrigendum). NATURE vol. 466, (7304)

Reynolds LE, Watson AR, Baker M, Jones TA, D'Amico G, Robinson SD, Joffre C, Garrido-Urbani S et al.(2010). Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome. Nature vol. 465, (7299) 813-817.

Forshew T, Lawson ARJ, Hindley GFL, Tatevossian RG, Jamie G, Ellison DW, Sheer D (2010). BREAKPOINT ANALYSIS OF RAF GENE FUSIONS IN PAEDIATRIC LOW-GRADE ASTROCYTOMAS. NEURO-ONCOLOGY. vol. 12, II23-II23.

Tatevossian RG, Lawson ARJ, Forshew T, Hindley GFL, Ellison DW, Sheer D(2010). MAPK pathway activation and the origins of pediatric low-grade astrocytomas. J Cell Physiol vol. 222, (3) 509-514.

Lever E, Sheer D(2010). The role of nuclear organization in cancer. J Pathol vol. 220, (2) 114-125.

Ellison D, Forshew T, Tatevossian R, Lawson A, Ma J, Neale G, Dalton J, Broniscer A et al. (2009). ABNORMALITIES OF THE MAPK PATHWAY IN PEDIATRIC LOW-GRADE GLIOMAS. NEURO-ONCOLOGY. vol. 11, 610-610.

Forshew T, Tatevossian RG, Lawson ARJ, Ma J, Neale G, Ogunkolade BW, Jones TA, Aarum J et al.(2009). Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas. J Pathol vol. 218, (2) 172-181.

Ellison D, Forshew T, Tatevossian R, Ma J, Neale G, Ogunkolade W, Dalton J, Bailey S et al.(2009). Activation of the MAPK Pathway: A Signature Genetic Defect in Posterior Fossa Pilocytic Astrocytomas. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY vol. 68, (5) 566-567.

Bax DA, Little SE, Gaspar N, Perryman L, Marshall L, Viana-Pereira M, Jones TA, Williams RD et al.(2009). Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development. PLoS One vol. 4, (4)

Ottaviani D, Lever E, Mitter R, Jones T, Forshew T, Christova R, Tomazou EM, Rakyan VK et al.(2008). Reconfiguration of genomic anchors upon transcriptional activation of the human major histocompatibility complex. Genome Res vol. 18, (11) 1778-1786.

Tatevossian R, Forshew T, Bax D, Mitter R, Jones C, Sheer D (2008). IDENTIFICATION OF CANDIDATE TUMOR SUPPRESSOR GENES IN PEDIATRIC ASTROCYTOMA USING NONSENSE-MEDIATED DECAY INHIBITION AND DEVELOPMENT OF A NOVEL GENE INTERACTION NETWORK. NEURO-ONCOLOGY. vol. 10, 803-803.

Forshew T, Tatevossian R, Clifford S, Ellison D, Sheer D (2008). MOLECULAR GENETIC AND EPIGENETIC ANALYSIS OF PEDIATRIC LOW-GRADE ASTROCYTIC GLIOMAS. NEURO-ONCOLOGY. vol. 10, 800-800.

Tomazou EM, Rakyan VK, Lefebvre G, Andrews R, Ellis P, Jackson DK, Langford C, Francis MD et al.(2008). Generation of a genomic tiling array of the human Major Histocompatibility Complex (MHC) and its application for DNA methylation analysis. BMC Med Genomics vol. 1, (1)

Ottaviani D, Lever E, Takousis P, Sheer D(2008). Anchoring the genome. Genome Biol vol. 9, (1)

Takousis P, Johonnett P, Williamson J, Sasieni P, Warnes G, Forshew T, Azuara V, Fisher A et al.(2007). Replication timing profile reflects the distinct functional and genomic features of the MHC class II region. CELL CYCLE vol. 6, (19) 2393-2398.

Christova R, Jones T, Wu P-J, Bolzer A, Costa-Pereira AP, Watling D, Kerr IM, Sheer D(2007). P-STAT1 mediates higher-order chromatin remodelling of the human MHC in response to IFNgamma. J Cell Sci vol. 120, (Pt 18) 3262-3270.

Donev R, Newall A, Thome J, Sheer D(2007). A role for SC35 and hnRNPA1 in the determination of amyloid precursor protein isoforms. MOL PSYCHIATR vol. 12, (7) 681-690.

Mulholland PJ, Fiegler H, Mazzanti C, Gorman P, Sasieni P, Adams J, Jones TA, Babbage JW et al.(2006). Genomic profiling identifies discrete deletions associated with translocations in glioblastoma multiforme. CELL CYCLE vol. 5, (7) 783-791.

Enukashvily N, Donev R, Sheer D, Podgornaya O(2005). Satellite DNA binding and cellular localisation of RNA helicase P68. J CELL SCI vol. 118, (3) 611-622.

Wang J, Shiels C, Sasieni P, Wu PJ, Islam SA, Freemont PS, Sheer D(2004). Promyelocytic leukemia nuclear bodies associate with transcriptionally active genomic regions. J Cell Biol vol. 164, (4) 515-526.

Donev R, Horton R, Beck S, Doneva T, Vatcheva R, Bowen WR, Sheer D(2003). Recruitment of heterogeneous nuclear ribonucleoprotein A1 in vivo to the LMP/TAP region of the major histocompatibility complex. J Biol Chem vol. 278, (7) 5214-5226.

Donev RM, Doneva TA, Bowen WR, Sheer D(2002). HnRNP-A1 binds directly to double-stranded DNA in vitro within a 36 bp sequence. MOL CELL BIOCHEM vol. 233, (1-2) 181-185.

Williams RRE, Broad S, Sheer D, Ragoussis J(2002). Subchromosomal positioning of the epidermal differentiation complex (EDC) in keratinocyte and lymphoblast interphase nuclei. EXP CELL RES vol. 272, (2) 163-175.

Shiels C, Islam SA, Vatcheva R, Sasieni P, Sternberg MJ, Freemont PS, Sheer D(2001). PML bodies associate specifically with the MHC gene cluster in interphase nuclei. J Cell Sci vol. 114, (Pt 20) 3705-3716.

Sheer D, Volpi E, Beck S, Horton R, Donev R(2001). Large-Scale chromatin structure and function in the Major Histocompatibility Complex. J MED GENET vol. 38, S16-S16.

Wu PJ, Bardos JI, Sheer D, Freemont P, Saha V(2001). Expression and association of the human trithorax and polycomb group of proteins. BRIT J CANCER vol. 85, 109-109.

Volpi EV, Sheer D, Uhlmann F(2001). Cohesion, but not too close. Curr Biol vol. 11, (10)

Abdel-Rahman WM, Katsura K, Rens W, Gorman PA, Sheer D, Bicknell D, Bodmer WF, Arends MJ et al.(2001). Spectral Karyotyping reveals a new subset of colorectal cancers characterized by balanced translocations. J PATHOL vol. 193, 24A-24A.

Abdel-Rahman WM, Katsura K, Rens W, Gorman PA, Sheer D, Bicknell D, Bodmer WF, Arends MJ et al.(2001). Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement. P NATL ACAD SCI USA vol. 98, (5) 2538-2543.

Schultz J, Jones T, Bork P, Sheer D, Blencke S, Steyrer S, Wellbrock U, Bevec D et al.(2001). Molecular characterization of a cDNA encoding functional human CLK4 kinase and localization to chromosome 4q35. GENOMICS vol. 71, (3) 368-370.

Sirivatanauksorn V, Sirivatanauksorn Y, Gorman PA, Davidson JM, Sheer D, Moore PS, Scarpa A, Edwards PAW et al.(2001). Non-random chromosomal rearrangements in pancreatic cancer cell lines identified by spectral karyotyping. INT J CANCER vol. 91, (3) 350-358.

Groet J, Ives JH, Jones TA, Chen L, Danton M, Flomen RH, Sheer D, Hrascan R et al.(2001). Allelic loss in the gene-poor band 21q11 -> q21 in squamous non-small cell lung carcinoma: cloning of a novel ubiquitin specific protease from the minimal deleted region. CYTOGENET CELL GENET vol. 92, (1-2) 16-16.

Woodford-Richens K, Williamson J, Bevan S, Young J, Leggett B, Frayling I, Thway Y, Hodgson S et al.(2000). Allelic loss at SMAD4 in polyps from juvenile polyposis patients and use of fluorescence in situ hybridization to demonstrate clonal origin of the epithelium. Cancer Research vol. 60, (9) 2477-2482.

Wang XC, Katso R, Butler R, Hanby AM, Poulsom R, Jones T, Sheer D, Ganesan TS(1996). H-RYK, an unusual receptor kinase: isolation and analysis of expression in ovarian cancer. Mol Med vol. 2, (2) 189-203.

Dunne J, Hanby AM, Poulsom R, Jones TA, Sheer D, Chin WG, Da SM, Zhao Q et al.(1995). Molecular cloning and tissue expression of FAT, the human homologue of the Drosophila fat gene that is located on chromosome 4q34-q35 and encodes a putative adhesion molecule. Genomics vol. 30, (2) 207-223.