Publications: Prof Denise Sheer

Boot J, Rosser G, Kancheva D, Vinel C, Lim YM, Pomella N, Zhang X, Guglielmi L et al. ( 2022 ) . Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape . eLife vol. 11 ,

Woodward L, Jones TA, Patel A, Dokal AD, Stone TJ, Rajeeve V, Cutillas PR, Jones DTW et al. ( 2022 ) . LGG-44. Multi-omic analysis reveals integrated signalling networks in paediatric low-grade glioma . Neuro-Oncology vol. 24 , ( Supplement_1 ) i98 - i98 .

Woodward L, Jones TA, Patel A, Dokal AD, Stone TJ, Rajeeve V, Cutillas PR, Jones DTW et al. ( 2022 ) . MULTI-OMIC ANALYSIS REVEALS INTEGRATED SIGNALLING NETWORKS IN PAEDIATRIC LOW-GRADE GLIOMA . NEURO-ONCOLOGY . vol. 24 , 98 - 98 .

Marino S ( 2021 ) . Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC‐derived neural stem cells in glioblastoma . Nature Communications

Adiutori R, Puentes F, Bremang M, Lombardi V, Zubiri I, Leoni E, Aarum J, Sheer D et al. ( 2021 ) . Analysis of circulating protein aggregates as a route of investigation into neurodegenerative disorders . Brain Communications vol. 3 , ( 3 )

Patel A, Jones T, Woodward L, Dokal A, Rajeeve V, Cutillas P, Stone T, Jacques T et al. ( 2020 ) . LGG-57. SIGNALLING MECHANISMS IN PAEDIATRIC LOW-GRADE GLIOMA . Neuro-Oncology vol. 22 , ( Suppl 3 ) iii377 - iii377 .

Patel A, Jones T, Woodward L, Dokal A, Rajeeve V, Cutillas P, Stone T, Jacques T et al. ( 2020 ) . LGG-57. SIGNALLING MECHANISMS IN PAEDIATRIC LOW-GRADE GLIOMA . Neuro-oncology vol. 22 , ( Suppl 3 ) iii377 - iii377 .

Aarum J, Cabrera CP, Jones TA, Rajendran S, Adiutori R, Giovannoni G, Barnes MR, Malaspina A et al. ( 2020 ) . Enzymatic degradation of RNA causes widespread protein aggregation in cell and tissue lysates . EMBO Reports vol. 21 , ( 10 ) Article ARTN e49585 ,

Aarum J, Cabrera CP, Jones TA, Rajendran S, Adiutori R, Giovannoni G, Barnes MR, Malaspina A et al. ( 2020 ) . Enzymatic degradation of RNA causes widespread protein aggregation in cell and tissue lysates . EMBO Reports vol. 21 , ( 10 )

Dumas A, Pomella N, Rosser G, Guglielmi L, Vinel C, Millner T, Rees J, Aley N et al. ( 2020 ) . Microglia promote glioblastoma via mTOR-mediated immunosuppression of the tumour microenvironment . The EMBO Journal

Patel A, Jones T, Woodward L, Dokal A, Rajeeve V, Cutillas P, Stone T, Jacques T et al. ( 2020 ) . SIGNALLING MECHANISMS IN PAEDIATRIC LOW-GRADE GLIOMA . NEURO-ONCOLOGY . vol. 22 , 377 - 377 .

Merve A, Zhang X, Pomella N, Acquati S, Hoeck JD, Dumas A, Rosser G, Li Y et al. ( 2019 ) . Correction to: c-MYC overexpression induces choroid plexus papillomas through a T-cell mediated inflammatory mechanism . Acta Neuropathologica Communications vol. 7 , ( 1 )

Merve A, Zhang X, Pomella N, Acquati S, Hoeck J, Dumas A, Rosser G, Li Y et al. ( 2019 ) . Choroid plexus papillomas are induced by c-Myc overexpression in the choroid plexus via a T-cell inflammatory mechanism . Neuro-Oncology . vol. 21 , 9 - 10 .

Merve A, Zhang X, Pomella N, Acquati S, Hoeck J, Dumas A, Rosser G, Li Y et al. ( 2019 ) . Choroid plexus papillomas are induced by c-Myc overexpression in the choroid plexus via a T-cell inflammatory mechanism . Neuro-oncology vol. 21 , ( Suppl 4 ) iv9 - iv10 .

Caley M, Marsh S, Martins VL, Corbett-Jones T, Chen M, Di W, Sheer D, McGrath JA et al. ( 2019 ) . 298 Defective DNA Repair and Chromosomal Instability in RDEB . Journal of Investigative Dermatology . vol. 139 ,

Merve A, Zhang X, Pomella N, Acquati S, Hoeck JD, Dumas A, Rosser G, Li Y et al. ( 2019 ) . c-MYC overexpression induces choroid plexus papillomas through a T-cell mediated inflammatory mechanism . Acta Neuropathologica Communications vol. 7 , ( 1 )

Fedorova L, Kost-Alimova M, Gizatullin RZ, Alimov A, Zabarovska VI, Szeles A, Protopopov AI, Vorobieva NV et al. ( 2019 ) . Assignment and ordering of twenty-three unique NotI-linking clones containing expressed genes including the guanosine 5'-monophosphate synthetase gene to human chromosome 3 . European Journal of Human Genetics vol. 5 , ( 2 ) 110 - 116 .

Marsh S, Caley MP, Martins VLC, Corbett-Jones T, Chen M, Di W, Sheer D, McGrath JA et al. ( 2019 ) . Type VII collagen and Nesprin 2: LINCing the basement membrane to altered cell cycle and increased DNA damage . BRITISH JOURNAL OF DERMATOLOGY . vol. 180 , E188 - E189 .

Adiutori R, Aarum J, Zubiri I, Bremang M, Jung S, Sheer D, Pike I, Malaspina A ( 2018 ) . The proteome of neurofilament-containing protein aggregates in blood . Biochemistry and Biophysics Reports vol. 14 , 168 - 177 .

Jeyapalan JN, Doctor GT, Jones TA, Alberman SN, Tep A, Haria CM, Schwalbe EC, Morley ICF et al. ( 2016 ) . DNA methylation analysis of paediatric low-grade astrocytomas identifies a tumour-specific hypomethylation signature in pilocytic astrocytomas . Acta Neuropathologica Communications vol. 4 , ( 1 )

Noor DAM, Jeyapalan JN, Alhazmi S, Carr M, Squibb B, Wallace C, Tan C, Cusack M et al. ( 2016 ) . Genome-wide methylation analysis identifies genes silenced in non-seminoma cell lines . npj Genomic Medicine vol. 1 , ( 1 )

Jones TA, Jeyapalan JN, Forshew T, Tatevossian RG, Lawson ARJ, Patel SN, Doctor GT, Mumin MA et al. ( 2015 ) . Molecular analysis of pediatric brain tumors identifies microRNAs in pilocytic astrocytomas that target the MAPK and NF-κB pathways . Acta Neuropathologica Communications vol. 3 , ( 1 )

Jeyapalan JN, Haria CM, Jones TA, Tatevossian RG, Qaddoumi I, Ellison DW, Sheer D ( 2015 ) . PO77EXPRESSION OF THE ONCOGENIC SPLICE VARIANT OF CYCLIN D1, CCND1B, IN PAEDIATRIC LOW GRADE GLIOMAS . Neuro-Oncology vol. 17 , ( suppl_8 ) viii14 - viii14 .

Coll-Bastus N, Mao X, Young BD, Sheer D, Lu Y-J ( 2015 ) . DNA replication-dependent induction of gene proximity by androgen . Hum Mol Genet vol. 24 , ( 4 ) 963 - 971 .

Sheer D, Jeyapalan J, Doctor GT, Jones TA, Alberman SN, Tep A, Haria CM, Schwalbe EC et al. ( 2015 ) . DNA METHYLATION ANALYSIS OF PAEDIATRIC LOW-GRADE ASTROCYTOMAS IDENTIFIES A TUMOUR-SPECIFIC SIGNATURE AT A SET OF ENHANCERS . PEDIATRIC BLOOD & CANCER vol. 62 , S283 - S284 .

Jeyapalan JN, Haria CM, Jones TA, Tatevossian RG, Qaddoumi I, Ellison DW, Sheer D ( 2015 ) . EXPRESSION OF THE ONCOGENIC SPLICE VARIANT OF CYCLIN D1, CCND1B, IN PAEDIATRIC LOW GRADE GLIOMAS . NEURO-ONCOLOGY . vol. 17 , 14 - 14 .

Jeyapalan JN, Jones TA, Tatevossian RG, Qaddoumi I, Ellison DW, Sheer D ( 2014 ) . OP17MICRORNA PROFILING USING SMALL RNA-SEQ IN PAEDIATRIC LOW GRADE GLIOMAS . Neuro-Oncology vol. 16 , ( suppl_6 ) vi19 - vi19 .

Ottaviani D, LeCain M, Sheer D ( 2014 ) . The role of microhomology in genomic structural variation . Trends Genet vol. 30 , ( 3 ) 85 - 94 .

Jeyapalan JN, Jones TA, Tatevossian RG, Qaddoumi I, Ellison D, Sheer D ( 2014 ) . MICRORNA PROFILING USING SMALL RNA-SEQ IN PAEDIATRIC LOW GRADE GLIOMAS . NEURO-ONCOLOGY . vol. 16 ,

Bastus NC, Mao X, Young BD, Sheer D, Lu Y-J ( 2014 ) . Novel function of androgen receptor-the regulation of DNA replication and genomic movement . INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE vol. 34 , S89 - S89 .

Ogunkolade BW, Jones TA, Aarum J, Szary J, Owen N, Ottaviani D, Mumin MA, Patel S et al. ( 2013 ) . BORIS/CTCFL is an RNA-binding protein that associates with polysomes . BMC Cell Biol vol. 14 ,

Henriquez NV, Forshew T, Tatevossian R, Ellis M, Richard-Loendt A, Rogers H, Jacques TS, Reitboeck PG et al. ( 2013 ) . Comparative expression analysis reveals lineage relationships between human and murine gliomas and a dominance of glial signatures during tumor propagation in vitro . Cancer Res vol. 73 , ( 18 ) 5834 - 5844 .

Zhang J, Wu G, Miller CP, Tatevossian RG, Dalton JD, Tang B, Orisme W, Punchihewa C et al. ( 2013 ) . Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas . Nature Genetics vol. 45 , ( 6 ) 602 - 612 .

Forshew T, Lewis P, Waldman A, Peterson D, Glaser M, Brock C, Sheer D, Mulholland PJ ( 2013 ) . Three different brain tumours evolving from a common origin . Oncogenesis vol. 2 , ( 4 )

Ottaviani D, Lever E, Mao S, Christova R, Ogunkolade BW, Jones TA, Szary J, Aarum J et al. ( 2012 ) . CTCF binds to sites in the major histocompatibility complex that are rapidly reconfigured in response to interferon-gamma . Nucleic Acids Res vol. 40 , ( 12 ) 5262 - 5270 .

Jeyapalan JN, Morley ICF, Hill AA, Mumin MA, Tatevossian RG, Qaddoumi I, Ellison DW, Sheer D ( 2012 ) . DNA METHYLATION PROFILING OF LOW GRADE ASTROCYTOMAS USING THE ILLUMINA 450K BEADCHIP REVEALS CHANGES IN GENES INVOLVED IN BRAIN DEVELOPMENT AND DRUG RESISTANCE . NEURO-ONCOLOGY . vol. 14 , 3 - 3 .

Jeyapalan JN, Patel SN, Forshew T, Lawson ARJ, Tatevossian RG, Corbett-Jones T, Mumin MA, Picker SR et al. ( 2012 ) . MICRORNA SIGNATURES IN A BROAD COHORT OF PAEDIATRIC BRAIN TUMOURS . PEDIATRIC BLOOD & CANCER vol. 59 , ( 6 ) 1084 - 1084 .

Viana-Pereira M, Pereira M, Burford A, Jury A, Popov S, Perryman L, Bax D, Forshew T et al. ( 2012 ) . MOLECULAR DETERMINANTS OF EFFICACY OF MET RECEPTOR INHIBITION IN PAEDIATRIC GLIOBLASTOMA . NEURO-ONCOLOGY . vol. 14 , 66 - 67 .

Tatevossian R, Qaddoumi I, Tang B, Dalton J, Shurtleff S, Punchihewa C, Orisme W, Neale G et al. ( 2012 ) . RAF GENE ABNORMALITIES DEFINE SUBSETS OF PEDIATRIC LOW-GRADE GLIOMAS AND GLIONEURONAL TUMORS . NEURO-ONCOLOGY . vol. 14 , 77 - 78 .

Ellison D, Tatevossian R, Qaddoumi I, Tang B, Dalton J, Shurtleff S, Punchihewa C, Orisme W et al. ( 2012 ) . RAF Gene Abnormalities Define Subsets of Pediatric Low-Grade Gliomas and Glioneuronal Tumors . JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY . vol. 71 , 577 - 577 .

Bezecny P, Sang NJPXWF, Mumin MA, Pieri C, Mulholland PJ, Sheer D ( 2011 ) . Addition of Erlotinib Changes Gene Expression in Glioblastoma Cell Lines Treated With Vorinostat . EUROPEAN JOURNAL OF CANCER . vol. 47 , S578 - S578 .

Tatevossian R, Tang B, Dalton J, Forshew T, Lawson A, Ma J, Neale G, Shurtleff S et al. ( 2011 ) . MYB UPREGULATION AND GENETIC ABERRATIONS IN A SUBSET OF PEDIATRIC LOW-GRADE GLIOMAS . NEURO-ONCOLOGY . vol. 13 , I5 - I5 .

Lawson ARJ, Hindley GFL, Forshew T, Tatevossian RG, Jamie GA, Kelly GP, Neale GA, Ma J et al. ( 2011 ) . RAF GENE FUSION BREAKPOINTS IN PEDIATRIC BRAIN TUMORS ARE CHARACTERIZED BY SIGNIFICANT ENRICHMENT OF SEQUENCE MICROHOMOLOGY . NEURO-ONCOLOGY . vol. 13 , I24 - I25 .

Lawson ARJ, Hindley GFL, Forshew T, Tatevossian RG, Jamie GA, Kelly GP, Neale GA, Ma J et al. ( 2011 ) . RAF gene fusion breakpoints in pediatric brain tumors are characterized by significant enrichment of sequence microhomology . Genome Res vol. 21 , ( 4 ) 505 - 514 .

Hashizume R, Aoki Y, Hariono S, Huillard E, Rowitch D, Jones C, Forshew T, Sheer D et al. ( 2011 ) . COMBINATION-TARGETED THERAPY SHOWS IMPROVED EFFICACY AGAINST BRAF<SUP>V600E</SUP> MUTANT MALIGNANT ASTROCYTOMAS . NEURO-ONCOLOGY . vol. 13 , I1 - I1 .

Jeyapalan JN, Mumin MA, Forshew T, Lawson ARJ, Tatevossian RG, Jacques TS, Sheer D ( 2011 ) . MICRORNA EXPRESSION IN PAEDIATRIC BRAIN TUMOURS . NEURO-ONCOLOGY . vol. 13 , 6 - 6 .

Nicolaides T, Hariono S, Barkovich K, Hashizume R, Rowitch D, Weiss W, Sheer D, Baker S et al. ( 2011 ) . TARGETED THERAPY FOR BRAFV600E MUTANT MALIGNANT ASTROCYTOMA . NEURO-ONCOLOGY vol. 13 , 112 - 112 .

Jones TA, Ogunkolade BW, Szary J, Aarum J, Mumin MA, Patel S, Pieri CA, Sheer D ( 2011 ) . Widespread expression of BORIS/CTCFL in normal and cancer cells . PLoS One vol. 6 , ( 7 )

Tatevossian RG, Tang B, Dalton J, Forshew T, Lawson AR, Ma J, Neale G, Shurtleff SA et al. ( 2010 ) . MYB upregulation and genetic aberrations in a subset of pediatric low-grade gliomas . ACTA NEUROPATHOL vol. 120 , ( 6 ) 731 - 743 .

Tatevossian R, Tang B, Forshew T, Lawson A, Dalton J, Ma J, Neale G, Broniscer A et al. ( 2010 ) . DNA COPY NUMBER CHANGES AND KIAA1549-BRAF FUSION GENE DETECTION IN 125 PEDIATRIC LOW-GRADE GLIOMAS . PEDIATR BLOOD CANCER vol. 55 , ( 5 ) 798 - 799 .

Bezecny P, Pieri C, Szary J, Mulholland PJ, Sheer D ( 2010 ) . HISTONE DEACETYLASE INHIBITOR VORINOSTAT REDUCES EXPRESSION OF PLATELET-DERIVED GROWTH FACTOR RECEPTOR A (PDGFRA) AND MATRIX METALLOPROTEINASE-2 (MMP2) GENES IN GLIOBLASTOMA CELL LINES . ANNALS OF ONCOLOGY . vol. 21 , 333 - 334 .

Lawson ARJ, Tatevossian RG, Phipps KP, Picker SR, Michalski A, Sheer D, Jacques TS, Forshew T ( 2010 ) . RAF gene fusions are specific to pilocytic astrocytoma in a broad paediatric brain tumour cohort . Acta Neuropathol vol. 120 , ( 2 ) 271 - 273 .

Reynolds LE, Watson AR, Baker M, Jones TA, D'Amico G, Robinson SD, Joffre C, Garrido-Urbani S et al. ( 2010 ) . Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome (Corrigendum) . NATURE vol. 466 , ( 7304 )

Reynolds LE, Watson AR, Baker M, Jones TA, D'Amico G, Robinson SD, Joffre C, Garrido-Urbani S et al. ( 2010 ) . Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome . Nature vol. 465 , ( 7299 ) 813 - 817 .

Forshew T, Lawson ARJ, Hindley GFL, Tatevossian RG, Jamie G, Ellison DW, Sheer D ( 2010 ) . BREAKPOINT ANALYSIS OF RAF GENE FUSIONS IN PAEDIATRIC LOW-GRADE ASTROCYTOMAS . NEURO-ONCOLOGY . vol. 12 , II23 - II23 .

Tatevossian RG, Lawson ARJ, Forshew T, Hindley GFL, Ellison DW, Sheer D ( 2010 ) . MAPK pathway activation and the origins of pediatric low-grade astrocytomas . J Cell Physiol vol. 222 , ( 3 ) 509 - 514 .

Lever E, Sheer D ( 2010 ) . The role of nuclear organization in cancer . J Pathol vol. 220 , ( 2 ) 114 - 125 .

Forshew T, Tatevossian RG, Lawson ARJ, Ma J, Neale G, Ogunkolade BW, Jones TA, Aarum J et al. ( 2009 ) . Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas . J Pathol vol. 218 , ( 2 ) 172 - 181 .

Ellison D, Forshew T, Tatevossian R, Ma J, Neale G, Ogunkolade W, Dalton J, Bailey S et al. ( 2009 ) . Activation of the MAPK Pathway: A Signature Genetic Defect in Posterior Fossa Pilocytic Astrocytomas . JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY vol. 68 , ( 5 ) 566 - 567 .

Dorine B, Little L, Gaspar N, Perryman L, Marshall L, Viana-Pereira M, Jones T, Williams RD et al. ( 2009 ) . Molecular and Phenotypic Characterisation of Paediatric Glioma Cell Lines as Models for Preclinical Drug Development . PLoS.ONE vol. 4 , ( 4 )

Ellison D, Forshew T, Tatevossian R, Lawson A, Ma J, Neale G, Dalton J, Broniscer A et al. ( 2009 ) . ABNORMALITIES OF THE MAPK PATHWAY IN PEDIATRIC LOW-GRADE GLIOMAS . NEURO-ONCOLOGY . vol. 11 , 610 - 610 .

Bax DA, Little SE, Gaspar N, Perryman L, Marshall L, Viana-Pereira M, Jones TA, Williams RD et al. ( 2009 ) . Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development . PLoS One vol. 4 , ( 4 )

Ottaviani D, Lever E, Mitter R, Jones T, Forshew T, Christova R, Tomazou EM, Rakyan VK et al. ( 2008 ) . Reconfiguration of genomic anchors upon transcriptional activation of the human major histocompatibility complex . Genome Res vol. 18 , ( 11 ) 1778 - 1786 .

Tatevossian R, Forshew T, Bax D, Mitter R, Jones C, Sheer D ( 2008 ) . IDENTIFICATION OF CANDIDATE TUMOR SUPPRESSOR GENES IN PEDIATRIC ASTROCYTOMA USING NONSENSE-MEDIATED DECAY INHIBITION AND DEVELOPMENT OF A NOVEL GENE INTERACTION NETWORK . NEURO-ONCOLOGY . vol. 10 , 803 - 803 .

Forshew T, Tatevossian R, Clifford S, Ellison D, Sheer D ( 2008 ) . MOLECULAR GENETIC AND EPIGENETIC ANALYSIS OF PEDIATRIC LOW-GRADE ASTROCYTIC GLIOMAS . NEURO-ONCOLOGY . vol. 10 , 800 - 800 .

Mao X, Jones TA, Williamson J, Gutowski NJ, Pröschel C, Noble M, Sheer D ( 2008 ) . Assignment of the human and mouse LIM-kinase genes (LIMK1; Limk1) to chromosome bands 7q11.23 and 5G1, respectively, by in situ hybridization . Cytogenetic and Genome Research vol. 74 , ( 3 ) 190 - 191 .

Xu W, Liu L, Gorman PA, Sheer D, Emson PC ( 2008 ) . Assignment of the human creatine transporter type 2 (SLC6A10) to chromosome band 16p11.2 by in situ hybridization . Cytogenetic and Genome Research vol. 76 , ( 1-2 ) 19 - 19 .

Zarn JA, Jackson DG, Bell MV, Jones T, Weber E, Sheer D, Waibel R, Stahel RA ( 2008 ) . The small cell lung cancer antigen cluster-4 and the leukocyte antigen CD24 are allelic isoforms of the same gene (CD24) on chromosome band 6q21 . Cytogenetic and Genome Research vol. 70 , ( 1-2 ) 119 - 125 .

Senger G, Ragoussis J, Trowsdale J, Sheer D ( 2008 ) . Fine mapping of the human MHC class II region within chromosome band 6p21 and evaluation of probe ordering using interphase fluorescence in situ hybridization . Cytogenetic and Genome Research vol. 64 , ( 1 ) 49 - 53 .

Jones TA, Barker HM, da Cruz e Silva EF, Mayer-Jaekel RE, Hemmings BA, Spurr NK, Sheer D, Cohen PTW ( 2008 ) . Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23→q31 and 8p12→p11.2, respectively . Cytogenetic and Genome Research vol. 63 , ( 1 ) 35 - 41 .

Shipley JM, Jones TA, Patel K, Kiely FM, De Stavola BL, Sheer D ( 2008 ) . Ordering of probes surrounding the Ewing's sarcoma breakpoint on chromosome 22 using fluorescent in situ hybridization to interphase nuclei . Cytogenetic and Genome Research vol. 64 , ( 3-4 ) 233 - 239 .

Xu W, Gorman P, Sheer D, Bates G, Kishimoto J, Lizhi L, Emson P ( 2008 ) . Regional localization of the gene coding for human brain nitric oxide synthase (NOS1) to 12q24.2→24.31 by fluorescent in situ hybridization . Cytogenetic and Genome Research vol. 64 , ( 1 ) 62 - 63 .

Barnett PS, Jones TA, McGregor AM, Banga JP, Sheer D ( 2008 ) . Regional sublocalization of the human thyroid peroxidase gene (TPO) by tritium and fluorescence in situ hybridization to chromosome 2p25→p24 . Cytogenetic and Genome Research vol. 62 , ( 4 ) 188 - 189 .

Fidlerová H, Senger G, Kost M, Sanseau P, Sheer D ( 2008 ) . Two simple procedures for releasing chromatin from routinely fixed cells for fluorescence in situ hybridization . Cytogenetic and Genome Research vol. 65 , ( 3 ) 203 - 205 .

Pajunen L, Jones TA, Goddard A, Sheer D, Solomon E, Pihlajaniemi T, Kivirikko KI ( 2008 ) . Regional assignment of the human gene coding for a multifunctional polypeptide (P4HB) acting as the β-subunit of prolyl 4-hydroxylase and the enzyme protein disulfide isomerase to 17q25 . Cytogenetic and Genome Research vol. 56 , ( 3-4 ) 165 - 168 .

Tomazou EM, Rakyan VK, Lefebvre G, Andrews R, Ellis P, Jackson DK, Langford C, Francis MD et al. ( 2008 ) . Generation of a genomic tiling array of the human Major Histocompatibility Complex (MHC) and its application for DNA methylation analysis . BMC Med Genomics vol. 1 , ( 1 )

Chan LC, Sheer D, Drysdale HC, Bevan D, Greaves MF ( 2008 ) . Monosomy 7 and multipotential stem cell transformation . British Journal of Haematology vol. 61 , ( 3 ) 531 - 539 .

Ottaviani D, Lever E, Takousis P, Sheer D ( 2008 ) . Anchoring the genome . Genome Biol vol. 9 , ( 1 )

Takousis P, Johonnett P, Williamson J, Sasieni P, Warnes G, Forshew T, Azuara V, Fisher A et al. ( 2007 ) . Replication timing profile reflects the distinct functional and genomic features of the MHC class II region . CELL CYCLE vol. 6 , ( 19 ) 2393 - 2398 .

BAI Y, SHEER D, HIORNS L, KNOWLES RW, TUNNACLIFFE A ( 2007 ) . A monoclonal antibody recognizing a cell surface antigen coded for by a gene on human chromosome 17 . Annals of Human Genetics vol. 46 , ( 4 ) 337 - 347 .

Goodfellow PJ, Nevanlinna HA, Gorman P, Sheer D, Lam G, Goodfellow PN ( 2007 ) . Assignment of the gene encoding the beta‐subunit of the human fibronectin receptor (β‐FNR) to chromosome 10p11.2 . Annals of Human Genetics vol. 53 , ( 1 ) 15 - 22 .

Solomon E, Hiorns L, Sheer D, Rowe D ( 2007 ) . Confirmation that the Type I collagen gene on chromosome 17 is COL1A1 (α1(I)), using a human genomic probe . Annals of Human Genetics vol. 48 , ( 1 ) 39 - 42 .

YON J, PALMER RW, SHEER D, FRIED M ( 2007 ) . Localization of the Surfeit gene cluster containing the ribosomal protein gene L7a to chromosome bands 9q33‐34 . Annals of Human Genetics vol. 53 , ( 2 ) 149 - 155 .

SHEER D, SHEPPARD DM, le BEAU M, ROWLEY JD, SAN ROMAN C, SOLOMON E ( 2007 ) . Localization of the oncogene c‐erbA1 immediately proximal to the acute promyelocytic leukaemia breakpoint on chromosome 17 . Annals of Human Genetics vol. 49 , ( 3 ) 167 - 171 .

RIDER SH, GORMAN PA, SHIPLEY JM, MOORE G, VENNSTROM B, SOLOMON E, SHEER D ( 2007 ) . Localization of the oncogene c‐erbA2 to human chromosome 3 . Annals of Human Genetics vol. 51 , ( 2 ) 153 - 160 .

MARTIN D, TUCKER DF, GORMAN P, SHEER D, SPURR NK, TROWSDALE J ( 2007 ) . The human placental alkaline phosphatase gene and related sequences map to chromosome 2 band q37 . Annals of Human Genetics vol. 51 , ( 2 ) 145 - 152 .

SWALLOW DM, GENDLER S, GRIFFITHS B, KEARNEY A, POVEY S, SHEER D, PALMER RW, TAYLOR‐PAPADIMITRIOU J ( 2007 ) . The hypervariable gene locus PUM, which codes for the tumour associated epithelial mucins, is located on chromosome 1, within the region 1g21–24 . Annals of Human Genetics vol. 51 , ( 4 ) 289 - 294 .

EDWARDS Y, WILLIAMS S, WEST L, LIPOWICZ S, SHEER D, ATTWOOD J, SPURR N, SARKAR R et al. ( 2007 ) . The polymorphic human DNA sequence D8S8 assigned to 8ql3‐21.1, close to the carbonic anhydrase gene cluster, by isotopic and non‐isotopic in situ hybridization and by linkage analysis . Annals of Human Genetics vol. 54 , ( 2 ) 131 - 139 .

Christova R, Jones T, Wu P-J, Bolzer A, Costa-Pereira AP, Watling D, Kerr IM, Sheer D ( 2007 ) . P-STAT1 mediates higher-order chromatin remodelling of the human MHC in response to IFNgamma . J Cell Sci vol. 120 , ( Pt 18 ) 3262 - 3270 .

Donev R, Newall A, Thome J, Sheer D ( 2007 ) . A role for SC35 and hnRNPA1 in the determination of amyloid precursor protein isoforms . MOL PSYCHIATR vol. 12 , ( 7 ) 681 - 690 .

Spurr NK, Durbin H, Sheer D, Parkar M, Bobrow L, Bodmer WF ( 2006 ) . Characterization and chromosomal assignment of a human cell surface antigen defined by the monoclonal antibody AUAI . International Journal of Cancer vol. 38 , ( 5 ) 631 - 636 .

Hill BT, Whelan RDH, Gibby EM, Hosking LK, Rupniak HT, Sheer D, Shellard SA ( 2006 ) . Establishment and characterisation of three new human ovarian carcinoma cell lines and initial evaluation of their potential in experimental chemotherapy studies . International Journal of Cancer vol. 39 , ( 2 ) 219 - 225 .

Paraskeva C, Buckle BG, Sheer D, Wigley CB ( 2006 ) . The isolation and characterization of colorectal epithelial cell lines at different stages in malignant transformation from familial polyposis coli patients . International Journal of Cancer vol. 34 , ( 1 ) 49 - 56 .

Shipley J, Williams S, O'Byrne A, Kearney L, Jones T, Young B, Dyer M, Catovsky D et al. ( 2006 ) . Characterization of a t(I0; II) (pI3‐I4; qI4‐2I) in the monoblastic cell line U937 . Genes Chromosomes and Cancer vol. 13 , ( 2 ) 138 - 142 .

Williams SV, Jones TA, Cottrell S, Zehetner G, Varesco L, Ward T, Thomas H, Lawson PA et al. ( 2006 ) . Fine Mapping of Probes in the Adenomatous Polyposis Coli Region of Chromosome 5 by In Situ Hybridization . Genes Chromosomes and Cancer vol. 3 , ( 5 ) 382 - 389 .

Gill S, McManus AP, Crew AJ, Benjamin H, Sheer D, Gusterson BA, Pinkerton CR, Patel K et al. ( 2006 ) . Fusion of the EWS Gene to a DNA segment from 9q22‐31 in a human myxoid chondrosarcoma . Genes Chromosomes and Cancer vol. 12 , ( 4 ) 307 - 310 .

Borrow J, Howe K, Goddard A, Solomon E, Shipley J, Kiely F, Sheer D, Srivastava A et al. ( 2006 ) . Molecular analysis of simple variant translocations in acute promyelocytic leukemia . Genes Chromosomes and Cancer vol. 9 , ( 4 ) 234 - 243 .

Mulholland PJ, Fiegler H, Mazzanti C, Gorman P, Sasieni P, Adams J, Jones TA, Babbage JW et al. ( 2006 ) . Genomic profiling identifies discrete deletions associated with translocations in glioblastoma multiforme . CELL CYCLE vol. 5 , ( 7 ) 783 - 791 .

LORD DK, CROSS NCP, BEVILACQUA MA, RIDER SH, GORMAN PA, GROVES AV, MOSS DW, SHEER D et al. ( 2005 ) . Type 5 acid phosphatase . The FEBS Journal vol. 189 , ( 2 ) 287 - 293 .

Enukashvily N, Donev R, Sheer D, Podgornaya O ( 2005 ) . Satellite DNA binding and cellular localisation of RNA helicase P68 . J CELL SCI vol. 118 , ( 3 ) 611 - 622 .

Wang J, Shiels C, Sasieni P, Wu PJ, Islam SA, Freemont PS, Sheer D ( 2004 ) . Promyelocytic leukemia nuclear bodies associate with transcriptionally active genomic regions . J Cell Biol vol. 164 , ( 4 ) 515 - 526 .

SASIENI PD, Wu PJ, Wang J, Shields C, Islam SA, Freemont PS, Sheer D ( 2004 ) . Promyelocytic leukaemia nuclear bodies associate with transcriptionally active genomic regions . Journal of Cell Biology. vol. 164 , ( 4 ) 515 - 526 .

BERCHTOLD S, JONES T, MÜHL‐ZÜRBES P, SHEER D, SCHULER G, STEINKASSERER A ( 2003 ) . The human dendritic cell marker CD83 maps to chromosome 6p23 . Annals of Human Genetics vol. 63 , ( 2 ) 181 - 183 .

Donev R, Horton R, Beck S, Doneva T, Vatcheva R, Bowen WR, Sheer D ( 2003 ) . Recruitment of heterogeneous nuclear ribonucleoprotein A1 in vivo to the LMP/TAP region of the major histocompatibility complex . J Biol Chem vol. 278 , ( 7 ) 5214 - 5226 .

Donev RM, Doneva TA, Bowen WR, Sheer D ( 2002 ) . HnRNP-A1 binds directly to double-stranded DNA in vitro within a 36 bp sequence . MOL CELL BIOCHEM vol. 233 , ( 1-2 ) 181 - 185 .

Williams RRE, Broad S, Sheer D, Ragoussis J ( 2002 ) . Subchromosomal positioning of the epidermal differentiation complex (EDC) in keratinocyte and lymphoblast interphase nuclei . EXP CELL RES vol. 272 , ( 2 ) 163 - 175 .

Shiels C, Islam SA, Vatcheva R, Sasieni P, Sternberg MJ, Freemont PS, Sheer D ( 2001 ) . PML bodies associate specifically with the MHC gene cluster in interphase nuclei . J Cell Sci vol. 114 , ( Pt 20 ) 3705 - 3716 .

Sheer D, Volpi E, Beck S, Horton R, Donev R ( 2001 ) . Large-Scale chromatin structure and function in the Major Histocompatibility Complex . J MED GENET vol. 38 , S16 - S16 .

Sheer D, Volpi EV ( 2001 ) . Human Chromosomes (4th Edition) . Chromosome Research vol. 9 , ( 6 ) 474 - 474 .

Wu PJ, Bardos JI, Sheer D, Freemont P, Saha V ( 2001 ) . Expression and association of the human trithorax and polycomb group of proteins . BRIT J CANCER vol. 85 , 109 - 109 .

Schultz J, Jones T, Bork P, Sheer D, Blencke S, Steyrer S, Wellbrock U, Bevec D et al. ( 2001 ) . Molecular Characterization of a cDNA Encoding Functional Human CLK4 Kinase and Localization to Chromosome 4q35 Volume 71, Number 3 (2001), pages 368–370 . Genomics vol. 74 , ( 2 )

Volpi EV, Sheer D, Uhlmann F ( 2001 ) . Cohesion, but not too close . Curr Biol vol. 11 , ( 10 )

Abdel-Rahman WM, Katsura K, Rens W, Gorman PA, Sheer D, Bicknell D, Bodmer WF, Arends MJ et al. ( 2001 ) . Spectral Karyotyping reveals a new subset of colorectal cancers characterized by balanced translocations . J PATHOL vol. 193 , 24A - 24A .

Abdel-Rahman WM, Katsura K, Rens W, Gorman PA, Sheer D, Bicknell D, Bodmer WF, Arends MJ et al. ( 2001 ) . Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement . P NATL ACAD SCI USA vol. 98 , ( 5 ) 2538 - 2543 .

Schultz J, Jones T, Bork P, Sheer D, Blencke S, Steyrer S, Wellbrock U, Bevec D et al. ( 2001 ) . Molecular characterization of a cDNA encoding functional human CLK4 kinase and localization to chromosome 4q35 . GENOMICS vol. 71 , ( 3 ) 368 - 370 .

Sirivatanauksorn V, Sirivatanauksorn Y, Gorman PA, Davidson JM, Sheer D, Moore PS, Scarpa A, Edwards PAW et al. ( 2001 ) . Non-random chromosomal rearrangements in pancreatic cancer cell lines identified by spectral karyotyping . INT J CANCER vol. 91 , ( 3 ) 350 - 358 .

Groet J, Ives JH, Jones TA, Chen L, Danton M, Flomen RH, Sheer D, Hrascan R et al. ( 2001 ) . Allelic loss in the gene-poor band 21q11 -> q21 in squamous non-small cell lung carcinoma: cloning of a novel ubiquitin specific protease from the minimal deleted region . CYTOGENET CELL GENET vol. 92 , ( 1-2 ) 16 - 16 .

SASIENI PD, Vatcheva R, Sheer D, Sternberg MJE, Freemont PS, Islam SA, Shiels C ( 2001 ) . PML bodies associate specifically with the MHC gene cluster in interphase nuclei . Journal of Cell Science vol. 114 , 3705 - 3716 .

Jones TA, Flomen RH, Senger G, Nižetić D, Sheer D ( 2000 ) . The homeobox gene MEIS1 is amplified in IMR-32 and highly expressed in other neuroblastoma cell lines . European Journal of Cancer vol. 36 , ( 18 ) 2368 - 2374 .

Chevret E, Volpi EV, Sheer D ( 2000 ) . Mini review: Form and function in the human interphase chromosome . Cytogenetic and Genome Research vol. 90 , ( 1-2 ) 13 - 21 .

Taylor CPF, Bown NP, McGuckin AG, Lunec J, Malcolm AJ, Pearson ADJ, Sheer D ( 2000 ) . Fluorescence in situ hybridization techniques for the rapid detection of genetic prognostic factors in neuroblastoma . British Journal of Cancer vol. 83 , ( 1 ) 40 - 49 .

Woodford-Richens K, Williamson J, Bevan S, Young J, Leggett B, Frayling I, Thway Y, Hodgson S et al. ( 2000 ) . Allelic loss at SMAD4 in polyps from juvenile polyposis patients and use of fluorescence in situ hybridization to demonstrate clonal origin of the epithelium . Cancer Research vol. 60 , ( 9 ) 2477 - 2482 .

Volpi EV, Chevret E, Jones T, Vatcheva R, Williamson J, Beck S, Campbell RD, Goldsworthy M et al. ( 2000 ) . Large-scale chromatin organization of the major histocompatibility complex and other regions of human chromosome 6 and its response to interferon in interphase nuclei . Journal of Cell Science vol. 113 , ( 9 ) 1565 - 1576 .

Wilson MJ, Torkar M, Haude A, Milne S, Jones T, Sheer D, Beck S, Trowsdale J ( 2000 ) . Plasticity in the organization and sequences of human KIR/ILT gene families . Proceedings of the National Academy of Sciences of the United States of America vol. 97 , ( 9 ) 4778 - 4783 .

Groet J, Ives JH, Jones TA, Danton M, Flomen RH, Sheer D, Hrašćan R, Pavelić K et al. ( 2000 ) . Narrowing of the region of allelic loss in 21q11‐21 in squamous non‐small cell lung carcinoma and cloning of a novel ubiquitin‐specific protease gene from the deleted segment . Genes Chromosomes and Cancer vol. 27 , ( 2 ) 153 - 161 .

Kashuba VI, Gizatullin RZ, Protopopov AI, Li J, Vorobieva NV, Fedorova L, Zabarovska VI, Muravenko OV et al. ( 1999 ) . Analysis of NotI linking clones isolated from human chromosome 3 specific libraries . Gene vol. 239 , ( 2 ) 259 - 271 .

Lamlum H, Ilyas M, Rowan A, Clark S, Johnson V, Bell J, Frayling I, Efstathiou J et al. ( 1999 ) . The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis . Nature Medicine vol. 5 , ( 9 ) 1071 - 1075 .

Roylance R, Gorman P, Harris W, Liebmann R, Barnes D, Hanby A, Sheer D ( 1999 ) . Comparative genomic hybridization of breast tumors stratified by histological grade reveals new insights into the biological progression of breast cancer . Cancer Research vol. 59 , ( 7 ) 1433 - 1436 .

Mao X, Jones TA, Tomlinson I, Rowan AJ, Fedorova LI, Zelenin AV, Mao J-I, Gutowski NJ et al. ( 1999 ) . Genetic aberrations in glioblastoma multiforme: translocation of chromosome 10 in an O-2A-like cell line . British Journal of Cancer vol. 79 , ( 5-6 ) 724 - 731 .

Herberg JA, Sgouros J, Jones T, Copeman J, Humphray SJ, Sheer D, Cresswell P, Beck S et al. ( 1998 ) . Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC . European Journal of Immunology vol. 28 , ( 2 ) 459 - 467 .

Saurin AJ, Shiels C, Williamson J, Satijn DPE, Otte AP, Sheer D, Freemont PS ( 1998 ) . The Human Polycomb Group Complex Associates with Pericentromeric Heterochromatin to Form a Novel Nuclear Domain . Journal of Cell Biology vol. 142 , ( 4 ) 887 - 898 .

Watt SM, Bühring H-J, Rappold I, Chan JY-H, Lee-Prudhoe J, Jones T, Zannettino ACW, Simmons PJ et al. ( 1998 ) . CD164, a Novel Sialomucin on CD34+ and Erythroid Subsets, Is Located on Human Chromosome 6q21 . Blood vol. 92 , ( 3 ) 849 - 866 .

Watt SM, Bühring H-J, Rappold I, Chan JY-H, Lee-Prudhoe J, Jones T, Zannettino ACW, Simmons PJ et al. ( 1998 ) . CD164, a novel sialomucin on CD34(+) and erythroid subsets, is located on human chromosome 6q21 . Blood vol. 92 , ( 3 ) 849 - 866 .

Herberg JA, Phillips S, Beck S, Jones T, Sheer D, Wu JJ, Prochazka V, Barr PJ et al. ( 1998 ) . Genomic structure and domain organisation of the human Bak gene . Gene vol. 211 , ( 1 ) 87 - 94 .

Chadwick BP, Williamson J, Sheer D, Frischauf A-M ( 1998 ) . cDNA cloning and chromosomal mapping of a mouse gene with homology to NTPases . Mammalian Genome vol. 9 , ( 2 ) 162 - 164 .

Chadwick BP, Heath SK, Williamson J, Obermayr F, Patel L, Sheer D, Frischauf A-M ( 1998 ) . The Human Homologue of theninjurinGene Maps to the Candidate Region of Hereditary Sensory Neuropathy Type I (HSNI) . Genomics vol. 47 , ( 1 ) 58 - 63 .

Howe K, Williamson J, Boddy N, Sheer D, Freemont P, Solomon E ( 1998 ) . The Ubiquitin-Homology GenePIC1:Characterization of Mouse (Pic1) and Human (UBL1) Genes and Pseudogenes . Genomics vol. 47 , ( 1 ) 92 - 100 .

Grimwade D, Gorman P, Duprez E, Howe K, Langabeer S, Oliver F, Walker H, Culligan D et al. ( 1997 ) . Characterization of cryptic rearrangements and variant translocations in acute promyelocytic leukemia . Blood vol. 90 , ( 12 ) 4876 - 4885 .

Watt SM, Buhriig HJ, Chan JHY, Rappold I, Lee-Prudhoe J, Benton MA, Jones T, Zannettino ACW et al. ( 1997 ) . The sialomicin CD164, a negative regulator of haemopoiesis, is expressed by CD34⁺ and erythroid subsets and is located on chromosome 6q21 . Experimental Hematology vol. 25 , ( 8 )

Thorpe KL, Gorman P, Thomas C, Sheer D, Trowsdale J, Beck S ( 1997 ) . Chromosomal localization, gene structure and transcription pattern of the ORFX gene, a homologue of the MHC-linked RING3 gene . Gene vol. 200 , ( 1-2 ) 177 - 183 .

McCusker D, Jones T, Sheer D, Trowsdale J ( 1997 ) . Genetic Relationships of the Genes Encoding the Human Proteasome β Subunits and the Proteasome PA28 Complex . Genomics vol. 45 , ( 2 ) 362 - 367 .

Flomen RH, Gorman PA, Vatcheva R, Groet J, Barisić I, Ligutić I, Sheer D, Nizetić D ( 1997 ) . Rieger syndrome locus: a new reciprocal translocation t(4;12)(q25;q15) and a deletion del(4)(q25q27) both break between markers D4S2945 and D4S193 . Journal of Medical Genetics vol. 34 , ( 3 )

Jones T, Sheer D, Bevec D, Kappel B, Hauber J, Steinkasserer A ( 1997 ) . The Human HIV-1 Rev Binding-Protein hRIP/Rab (HRB) Maps to Chromosome 2q36 . Genomics vol. 40 , ( 1 ) 198 - 199 .

Roylance R, Spurr N, Sheer D ( 1997 ) . The genetic analysis of prostate carcinoma . Seminars in Cancer Biology vol. 8 , ( 1 ) 37 - 44 .

Ruhrberg C, Williamson JA, Sheer D, Watt FM ( 1996 ) . Chromosomal Localisation of the Human Envoplakin Gene (EVPL) to the Region of the Tylosis Oesophageal Cancer Gene (TOCG) on 17q25 . Genomics vol. 37 , ( 3 ) 381 - 385 .

Jones T, Sheer D, Kapetanopoulos A, Hauber J, Bevec D, Steinkasserer A ( 1996 ) . The Gene Coding for Human Deoxyhypusine Synthase (DHPS) Maps to Chromosome 19p13.11–p13.12 . Genomics vol. 35 , ( 3 ) 635 - 636 .

Williamson JA, Bosher JM, Skinner A, Sheer D, Williams T, Hurst HC ( 1996 ) . Chromosomal Mapping of the Human and Mouse Homologues of Two New Members of the AP-2 Family of Transcription Factors . Genomics vol. 35 , ( 1 ) 262 - 264 .

Tassabehji M, Metcalfe K, Fergusson WD, Carette MJA, Dore JK, Donnai D, Read AP, Pröschel C et al. ( 1996 ) . LIM–kinase deleted in Williams syndrome . Nature Genetics vol. 13 , ( 3 ) 272 - 273 .

Thomas HJ, Whitelaw SC, Cottrell SE, Murday VA, Tomlinson IP, Markie D, Jones T, Bishop DT et al. ( 1996 ) . Genetic mapping of hereditary mixed polyposis syndrome to chromosome 6q . American Journal of Human Genetics vol. 58 , ( 4 ) 770 - 776 .

Wang XC, Katso R, Butler R, Hanby AM, Poulsom R, Jones T, Sheer D, Ganesan TS ( 1996 ) . H-RYK, an Unusual Receptor Kinase: Isolation and Analysis of Expression in Ovarian Cancer . Molecular Medicine vol. 2 , ( 2 ) 189 - 203 .

Sheer D, Squire J ( 1996 ) . Clinical applications of genetic rearrangements in cancer . Seminars in Cancer Biology vol. 7 , ( 1 ) 25 - 32 .

Han X, Papadopoulos AJ, Jones TA, Sheer D, Raju KS ( 1996 ) . SR8—The establishment and characterisation of a new ovarian carcinoma cell line and xenograft model . European Journal of Cancer vol. 32 , ( 1 ) 160 - 167 .

Waxman J, Sheer D ( 1995 ) . Is prostate cancer worth diagnosing? . The Lancet vol. 346 , ( 8984 ) 1177 - 1178 .

Dunne J, Hanby AM, Poulsom R, Jones TA, Sheer D, Chin WG, Da SM, Zhao Q et al. ( 1995 ) . Molecular Cloning and Tissue Expression ofFAT,the Human Homologue of theDrosophila fatGene That Is Located on Chromosome 4q34–q35 and Encodes a Putative Adhesion Molecule . Genomics vol. 30 , ( 2 ) 207 - 223 .

Steinkasserer A, Jones T, Sheer D, Koettnitz K, Hauber J, Bevec D ( 1995 ) . The eukaryotic cofactor for the human immunodeficiency virus type 1 (HIV-1) rev protein, eIF-5A, maps to chromosome 17p12–p13: three eIF-5A pseudogenes map to 10q23.3, 17q25, and 19q13.2 . Genomics vol. 25 , ( 3 ) 749 - 752 .

Shipley J, Sheer D, Dalton S, Treisman R, Patel K ( 1994 ) . Mapping of the Human SAP1 (SRF Accessory Protein 1) Gene and SAP2, a Gene Encoding a Related Protein, to Chromosomal Bands 1q32 and 12q23, Respectively . Genomics vol. 23 , ( 3 ) 710 - 711 .

Belich MP, Glynne RJ, Senger G, Sheer D, Trowsdale J ( 1994 ) . Proteasome components with reciprocal expression to that of the MHC-encoded LMP proteins . Current Biology vol. 4 , ( 9 ) 769 - 776 .

Delattre O, Zucman J, Melot T, Garau XS, Zucker J-M, Lenoir GM, Ambros PF, Sheer D et al. ( 1994 ) . The Ewing Family of Tumors -- A Subgroup of Small-Round-Cell Tumors Defined by Specific Chimeric Transcripts . New England Journal of Medicine vol. 331 , ( 5 ) 294 - 299 .

Sanséau P, Jackson A, Alderton RP, Beck S, Senger G, Sheer D, Kelly A, Trowsdale J ( 1994 ) . Cloning and characterization of human phosphatase inhibitor-2 (IPP-2) sequences . Mammalian Genome vol. 5 , ( 8 ) 490 - 496 .

Senger G, A.Jones T, Fldlerová H, Sanséau P, Trowsdale J, Duff M, Sheer D ( 1994 ) . Released chromatin: linearized DNA for high resolution fluorescence in situ hybridization . Human Molecular Genetics vol. 3 , ( 8 ) 1275 - 1280 .

Sanséau P, Jackson A, Senger G, Kelly A, Francis F, Sheer D, Trowsdale J ( 1994 ) . Cloning of the region between HLA-DMB and LMP2 in the human major histocompatibility complex . Human Immunology vol. 40 , ( 1 ) 1 - 7 .

Xu W, Charles IG, Moncada S, Gorman P, Sheer D, Liu L, Emson P ( 1994 ) . Mapping of the Genes Encoding Human Inducible and Endothelial Nitric Oxide Synthase (NOS2 and NOS3) to the Pericentric Region of Chromosome 17 and to Chromosome 7, Respectively . Genomics vol. 21 , ( 2 ) 419 - 422 .

Emslie EA, Jones TA, Sheer D, Keyse SM ( 1994 ) . The CL100 gene, which encodes a dual specificity (Tyr/Thr) MAP kinase phosphatase, is highly conserved and maps to human chromosome 5q34 . Human Genetics vol. 93 , ( 5 ) 513 - 516 .

Samec S, Jones TA, Corlet J, Scherly D, Sheer D, Wood RD, Clarkson SG ( 1994 ) . The Human Gene for Xeroderma Pigmentosum Complementation Group G (XPG) Maps to 13q33 by Fluorescence in Situ Hybridization . Genomics vol. 21 , ( 1 ) 283 - 285 .

Taylor C, McGuckin A, Bown N, Reid M, Malcolm A, Pearson A, Sheer D ( 1994 ) . Rapid detection of prognostic genetic factors in neuroblastoma using fluorescence in situ hybridisation on tumour imprints and bone marrow smears . British Journal of Cancer vol. 69 , ( 3 ) 445 - 451 .

Ben-Arie N, Lancet D, Taylor C, Khen M, NaomlWalker, Ledbetter DH, Carrozzo R, Patel K et al. ( 1994 ) . Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire . Human Molecular Genetics vol. 3 , ( 2 ) 229 - 235 .

Zucman J, Melot T, Desmaze C, Ghysdael J, Plougastel B, Peter M, Zucker JM, Triche TJ et al. ( 1993 ) . Combinatorial generation of variable fusion proteins in the Ewing family of tumours . The EMBO Journal vol. 12 , ( 12 ) 4481 - 4487 .

Ward JRT, Cottrell S, Thomas HJW, Jones TA, Howe CM, Hampton GM, Deaven L, Sheer D et al. ( 1993 ) . A Long-Range Restriction Map of Human Chromosome 5q21-q23 . Genomics vol. 17 , ( 1 ) 15 - 24 .

Patel K, Sheer D, Hampton GM ( 1993 ) . “Junction trapping” a simple PCR-based method for the isolation of YAC-insert termini . New Biotechnology vol. 10 , ( 2 ) 42 - 48 .

Markie D, Ragoussis J, Senger G, Rowan A, Sansom D, Trowsdale J, Sheer D, Bodmer WF ( 1993 ) . New vector for transfer of yeast artificial chromosomes to mammalian cells . Somatic Cell and Molecular Genetics vol. 19 , ( 2 ) 161 - 169 .

Yon J, Jones T, Garson K, Sheer D, Fried M ( 1993 ) . The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1 . Human Molecular Genetics vol. 2 , ( 3 ) 237 - 240 .

Abrahamsen TG, Wesenberg F, Mørk S, Allen J, Hayes R, DaRosso R, Nirenberg A, Ali-Osman F et al. ( 1993 ) . Abstracts for the Tenth International Conference on Brain Tumour Research and Therapy . Journal of Neuro-Oncology vol. 15 , ( Suppl 1 ) s1 - s30 .

Taylor C, Patel K, Jones T, Kiely F, De Stavola B, Sheer D ( 1993 ) . Diagnosis of Ewing's sarcoma and peripheral neuroectodermal tumour based on the detection of t(11;22) using fluorescence in situ hybridisation . British Journal of Cancer vol. 67 , ( 1 ) 128 - 133 .

Cole CG, Patel K, Shipley J, Sheer D, Bobrow M, Bentley DR, Dunham I ( 1992 ) . Identification of region-specific yeast artificial chromosomes using pools of Alu element-mediated polymerase chain reaction probes labeled via linear amplification . Genomics vol. 14 , ( 4 ) 931 - 938 .

Jenkins JR, Ayton P, Jones T, Davies SL, Simmons DL, Harris AL, Sheer D, Hickson ID ( 1992 ) . Isolation of cDNA clones encoding the β isozyme of human DNA topoisomerase II and localisation of the gene to chromosome 3p24 . Nucleic Acids Research vol. 20 , ( 21 ) 5587 - 5592 .

Ragoussis J, Senger G, Mockridge I, Sanseau P, Ruddy S, Dudley K, Sheer D, Trowsdale J ( 1992 ) . A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the t-complex gene tcp-11 . Genomics vol. 14 , ( 3 ) 673 - 679 .

Markie D, Jones TA, Sheer D, Bodmer WF ( 1992 ) . A somatic cell hybrid panel for regional mapping of human chromosome 18 . Genomics vol. 14 , ( 2 ) 431 - 436 .

Calabrese G, Palka G, Westbrook CA, Sheer D ( 1992 ) . Complex translocation involving Ph chromosome in a patient with typical chronic myelogenous leukemia . Cancer Genetics vol. 63 , ( 1 ) 52 - 55 .

Hampton GM, Ward JR, Cottrell S, Howe K, Thomas HJ, Ballhausen WG, Jones T, Sheer D et al. ( 1992 ) . Yeast artificial chromosomes for the molecular analysis of the familial polyposis APC gene region . Proceedings of the National Academy of Sciences of the United States of America vol. 89 , ( 17 ) 8249 - 8253 .

Lennard A, Gorman P, Carrier M, Griffiths S, Scotney H, Sheer D, Solari R ( 1992 ) . Cloning and chromosome mapping of the human interleukin-1 receptor antagonist gene . Cytokine vol. 4 , ( 2 ) 83 - 89 .

Hämäläinen E-R, Jones TA, Sheer D, Taskinen K, Pihlajaniemi T, Kivirikko KI ( 1991 ) . Molecular cloning of human lysyl oxidase and assignment of the gene to chromosome 5q23.3–31.2 . Genomics vol. 11 , ( 3 ) 508 - 516 .

Heard E, Williams SV, Sheer D, Fried M ( 1991 ) . Gene amplification accompanied by the loss of a chromosome containing the native allele and the appearance of the amplified DNA at a new chromosomal location . Proceedings of the National Academy of Sciences of the United States of America vol. 88 , ( 18 ) 8242 - 8246 .

Patel K, Cox R, Shipley J, Kiely F, Frazer K, Cox DR, Lehrach H, Sheer D ( 1991 ) . A novel and rapid method for isolating sequences adjacent to rare cutting sites and their use in physical mapping . Nucleic Acids Research vol. 19 , ( 16 ) 4371 - 4375 .

Ragoussis J, Jones TA, Sheer D, Shrimpton AE, Goodfellow PN, Trowsdale J, Ziegler A ( 1991 ) . Isolation of probes specific to human chromosomal region 6p21 from immunoselected irradiation-fusion gene transfer hybrids . Genomics vol. 10 , ( 3 ) 598 - 607 .

Dietrich A, Kioschis P, Monaco AP, Gross B, Korn B, Williams SV, Sheer D, Heitz D et al. ( 1991 ) . Molecular cloning and analysis of the fragile X region in man . Nucleic Acids Research vol. 19 , ( 10 ) 2567 - 2572 .

Gorman PA, Malone M, Pritchard J, Sheer D ( 1991 ) . Cytogenetic analysis of primitive neuroectodermal tumors Absence of the t(11;22) in two of three cases and a review of the literature . Cancer Genetics vol. 51 , ( 1 ) 13 - 22 .

Wynford-Thomas D, Bond JA, Wyllie FS, Burns JS, Williams ED, Jones T, Sheer D, Lemoine NR ( 1990 ) . Conditional Immortalization of Human Thyroid Epithelial Cells: A Tool for Analysis of Oncogene Action . Molecular and Cellular Biology vol. 10 , ( 10 ) 5365 - 5377 .

Borrow J, Goddard AD, Sheer D, Solomon E ( 1990 ) . Molecular Analysis of Acute Promyelocytic Leukemia Breakpoint Cluster Region on Chromosome 17 . Science vol. 249 , ( 4976 ) 1577 - 1580 .

Gorman PA, Malone M, Pritchard J, Sheer D ( 1990 ) . Deletion of part of the short arm of chromosome 17 in a congenital fibrosarcoma . Cancer Genetics vol. 48 , ( 2 ) 193 - 198 .

Barker HM, Jones TA, da Cruz e Silva EF, Spurr NK, Sheer D, Cohen PTW ( 1990 ) . Localization of the gene encoding a type I protein phosphatase catalytic subunit to human chromosome band 11q13 . Genomics vol. 7 , ( 2 ) 159 - 166 .

Myers JC, Jones TA, Pohjolainen ER, Kadri AS, Goddard AD, Sheer D, Solomon E, Pihlajaniemi T ( 1990 ) . Molecular cloning of alpha 5(IV) collagen and assignment of the gene to the region of the X chromosome containing the Alport syndrome locus . American Journal of Human Genetics vol. 46 , ( 6 ) 1024 - 1033 .

Sheer D, Gorman PA, Whelan R, Hill BT ( 1990 ) . Cytogenetic analysis of a cell line established from a Krukenberg tumor . Cancer Genetics vol. 46 , ( 1 ) 71 - 74 .

Jones TA, da Cruz e Silva EF, Spurr NK, Sheer D, Cohen PTW ( 1990 ) . Localisation of the gene encoding the catalytic γ subunit of phosphorylase kinase to human chromosome bands 7p12-q21 . Biochimica et Biophysica Acta vol. 1048 , ( 1 ) 24 - 29 .

Pajunen L, Jones TA, Helaakoski T, Pihlajaniemi T, Solomon E, Sheer D, Kivirikko KI ( 1989 ) . Assignment of the gene coding for the alpha-subunit of prolyl 4-hydroxylase to human chromosome region 10q21.3-23.1 . American Journal of Human Genetics vol. 45 , ( 6 ) 829 - 834 .

Lemoine N, Mayall E, Jones T, Sheer D, McDermid S, Kendall-Taylor P, Wynford-Thomas D ( 1989 ) . Characterisation of human thyroid epithelial cells immortalised in vitro by simian virus 40 DNA transfection . British Journal of Cancer vol. 60 , ( 6 ) 897 - 903 .

Varesco L, Thomas HJ, Cottrell S, Murday V, Fennell SJ, Williams S, Searle S, Sheer D et al. ( 1989 ) . CpG island clones from a deletion encompassing the gene for adenomatous polyposis coli . Proceedings of the National Academy of Sciences of the United States of America vol. 86 , ( 24 ) 10118 - 10122 .

Davies AA, Moss SE, Crompton MR, Jones TA, Spurr NK, Sheer D, Kozak C, Crumpton MJ ( 1989 ) . The gene coding for the p68 calcium-binding protein is localised to bands q32–q34 of human chromosome 5, and to mouse chromosome 11 . Human Genetics vol. 82 , ( 3 ) 234 - 238 .

Moore G, Hedge PJ, Rider SH, Xu W, Hing S, Palmer R, Sheer D, Solomon E ( 1989 ) . Multiple tandem 18-kb sequences clustered in the region of the acute promyelocytic leukemia breakpoint on chromosome 17 . Genomics vol. 4 , ( 2 ) 152 - 161 .

Shipley J, Sheer D ( 1989 ) . Deletion of c-ets1 and T3γ loci from the 11q- chromosome in the human monoblastic cell line U937 . Leukemia Research vol. 13 , ( 6 ) 445 - 450 .

MURDAY V, COTTRELL S, BODMER WF, SHEER D, JONES TA, VARESCO L, FRISCHAUF AM, THOMAS HJ et al. ( 1989 ) . FINE LINKAGE MAP AROUND THE ADENOMATOUS POLYPOSIS (APC) GENE . CYTOGENETICS AND CELL GENETICS . vol. 51 , 1049 - 1049 .

Xu WM, Gorman PA, Rider SH, Hedge PJ, Moore G, Prichard C, Sheer D, Solomon E ( 1988 ) . Construction of a genetic map of human chromosome 17 by use of chromosome-mediated gene transfer . Proceedings of the National Academy of Sciences of the United States of America vol. 85 , ( 22 ) 8563 - 8567 .

Sewell WA, Palmer RW, Spurr NK, Sheer D, Brown MH, Bell Y, Crumpton MJ ( 1988 ) . The human LFA-3 gene is located at the same chromosome band as the gene for its receptor CD2 . Immunogenetics vol. 28 , ( 4 ) 278 - 282 .

Whelan R, Gibby E, Sheer D, Povey S, Hill BT ( 1988 ) . Characterization of a continuous cell line in culture established from a Krukenberg tumour of the ovary arising from a primary gastric adenocarcinoma . European Journal of Cancer vol. 24 , ( 9 ) 1397 - 1408 .

Williams BP, Daniels GL, Pym B, Sheer D, Povey S, Okubo Y, Andrews PW, Goodfellow PN ( 1988 ) . Biochemical and genetic analysis of the Oka blood group antigen . Immunogenetics vol. 27 , ( 5 ) 322 - 329 .

Shipley JM, Sheppard DM, Sheer D ( 1988 ) . Karyotypic analysis of the human monoblastic cell line U937 . Cancer Genetics vol. 30 , ( 2 ) 277 - 284 .

Krissansen GW, Gorman PA, Kozak CA, Spurr NK, Sheer D, Goodfellow PN, Crumpton MJ ( 1987 ) . Chromosomal locations of the gene coding for the CD3 (T3) γ subunit of the human and mouse CD3/T-cell antigen receptor complexes . Immunogenetics vol. 26 , ( 4-5 ) 258 - 266 .

Willison K, Kelly A, Dudley K, Goodfellow P, Spurr N, Groves V, Gorman P, Sheer D et al. ( 1987 ) . The human homologue of the mouse t‐complex gene, TCP1, is located on chromosome 6 but is not near the HLA region . The EMBO Journal vol. 6 , ( 7 ) 1967 - 1974 .

Sheer D, Sheppard DM, Gorman PA, Ward B, Whelan RDH, Hill BT ( 1987 ) . Cytogenetic analysis of four human ovarian carcinoma cell lines . Cancer Genetics vol. 26 , ( 2 ) 339 - 349 .

Brown MH, Gorman PA, Sewell WA, Spurr NK, Sheer D, Crumpton MJ ( 1987 ) . The gene coding for the human T-lymphocyte CD2 antigen is located on chromosome 1p . Human Genetics vol. 76 , ( 2 ) 191 - 195 .

Rider SH, Bailey CJ, Voss R, Sheer D, Hiorns LR, Solomon E ( 1987 ) . RFLP for the human erb-A1 gene . Nucleic Acids Research vol. 15 , ( 2 ) 863 - 863 .

Eridani S, Gorman P, Sheer D, Duncombe AS, Glass UH, Shivji MKK ( 1987 ) . Monosomy 7 and Ph-positive acute lymphoblastic leukaemia: Cytogenetic and molecular aspects . Leukemia Research vol. 11 , ( 11 ) 965 - 969 .

Sheer D ( 1985 ) . Genetic aspects of carcinogenesis . British Journal of Surgery vol. 72 , ( Supplement_1 ) s39 - s41 .

Benchimol S, Lamb P, Crawford LV, Sheer D, Shows TB, Bruns GAP, Peacock J ( 1985 ) . Transformation associated p53 protein is encoded by a gene on human chromosome 17 . Somatic Cell and Molecular Genetics vol. 11 , ( 5 ) 505 - 510 .

Sheer D, Lister TA, Amess J, Solomon E ( 1985 ) . Incidence of the 15q+;17q- chromosome translocation in acute promyelocytic leukaemia (APL) . British Journal of Cancer vol. 52 , ( 1 ) 55 - 58 .

Spurr NK, Solomon E, Jansson M, Sheer D, Goodfellow PN, Bodmer WF, Vennstrom B ( 1984 ) . Chromosomal localisation of the human homologues to the oncogenes erbA and B . The EMBO Journal vol. 3 , ( 1 ) 159 - 163 .

Sheer D, Hiorns LR, Stanley KF, Goodfellow PN, Swallow DM, Povey S, Heisterkamp N, Groffen J et al. ( 1983 ) . Genetic analysis of the 15;17 chromosome translocation associated with acute promyelocytic leukemia . Proceedings of the National Academy of Sciences of the United States of America vol. 80 , ( 16 ) 5007 - 5011 .

Goodfellow P, Banting G, Sheer D, Ropers HH, Caine A, Ferguson-Smith MA, Povey S, Voss R ( 1983 ) . Genetic evidence that a Y-linked gene in man is homologous to a gene on the X chromosome . Nature vol. 302 , ( 5906 ) 346 - 349 .

Sheer D, Solomon E, Greaves MF, Lister TA ( 1982 ) . 1517 chromosome translocation in acute promyelocytic leukemia . Cancer Genetics vol. 5 , ( 4 ) 353 - 354 .

Sheer D, Brown RM, Bobrow M ( 1982 ) . Carcinoembryonic antigen (CEA) expression in somatic cell hybrids . Somatic Cell Genetics vol. 8 , ( 1 ) 1 - 13 .