Publications:  Prof Rupert Pearse

COVIDSurg Collaborative(2020). Elective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans. British Journal of Surgery

Fowler A, Dobbs T, Wan Y, Laloo R, Hui S, Nepogodiev D, Pearse RM, ABBOTT T (2020). Estimated surgical requirements in England after COVID-19: a modelling study using hospital episode statistics.

Wan YI, Patel A, ABBOTT TEF, Achary C, Macdonald N, Duceppe E, Sessler DI, Szczeklik W et al.(2020). Prospective observational study of postoperative infection and outcomes after noncardiac surgery: analysis of prospective data from the VISION cohort. British Journal of Anaesthesia

Bangash MN, Abbott TEF, Patel NSA, Hinds C, Thiemermann C, Pearse R(2020). The Effect of β2-Adrenoceptor Agonists on Leucocyte-Endothelial Adhesion in a Rodent Model of Laparotomy and Endotoxemia. Frontiers in Immunology vol. 11,

Thomas S, Borges F, Bhandari M, De Beer J, Urrútia Cuchí G, Adili A, Winemaker M, Avram V et al.(2020). Association Between Myocardial Injury and Cardiovascular Outcomes of Orthopaedic Surgery: A Vascular Events in Noncardiac Surgery Patients Cohort Evaluation (VISION) Substudy. The Journal of bone and joint surgery. American volume vol. 102, (10) 880-888.

Wan Y, Apea V, Dhairyawan R, Orkin C, Pearse RM, Prowle JR (2020). ETHICAL: Ethnic Disparities In COVID-19 Admissions in east London.

Shaw S, Hughes G, Stephens T, Pearse R, Prowle J, Ashcroft RE, Avagliano E, Day J et al.(2020). Understanding decision making about major surgery: protocol for a qualitative study of shared decision making by high-risk patients and their clinical teams. BMJ open vol. 10, (5)

ABBOTT T, Pearse R, Chew M(2020). Prevention of postoperative pulmonary complications in the hypoxaemic patient - gathering the evidence for noninvasive respiratory support. European Journal of Anaesthesiology vol. 37, (4) 263-263.

Ackland GL, ABBOTT T, Jones TF, Leuwer M, Pearse R, Niebrzegowska E, Wragg A, Archbold A et al.(2020). Early elevation in plasma high-sensitivity troponin T and morbidity after elective noncardiac surgery: prospective multicentre observational cohort study. British Journal of Anaesthesia

Duceppe E, Patel A, Chan MTV, Berwanger O, Ackland G, Kavsak PA, Rodseth R, Biccard B et al.(2020). Preoperative n-terminal pro-b-type natriuretic peptide and cardiovascular events after noncardiac surgery: A cohort study. Annals of Internal Medicine vol. 172, (2) 96-104.

Turan A, Artis AS, Hanline C, Saha P, Maheshwari K, Kurz A, Devereaux PJ, Duceppe E et al.(2020). Preoperative Vitamin D Concentration and Cardiac, Renal, and Infectious Morbidity after Noncardiac Surgery. Anesthesiology vol. 132, (1) 121-130.

Wan Y, McGuckin D, Fowler A, Prowle J, Pearse R, Moonesinghe R (2020). Socioeconomic deprivation and surgical outcomes: ISOS and VISION-UK sub-study (Statistical Analysis Plan).

Wijeysundera D, Beattie WS, Hillis G, ABBOTT T, Shulman M, Ackland G, Mazer D, Myles P et al.(2019). Integration of the Duke Activity Status Index into Preoperative Risk Evaluation: A Multicentre Prospective Cohort Study. British Journal of Anaesthesia

Scheeren TWL, Bakker J, De Backer D, Annane D, Asfar P, Boerma EC, Cecconi M, Dubin A et al.(2019). Current use of vasopressors in septic shock. Annals of Intensive Care vol. 9, (1)

Yang F, Walker S, Richardson G, Stephens T, Phull M, Thompson A, Pearse RM(2019). Reply letter to: “A commentary on “cost-effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery, health economic evaluation” (int J Surg 2019; epub ahead of print)”. International Journal of Surgery vol. 72, 252-253.

Gillies MA, Ghaffar S, Harrison E, Haddow C, Smyth L, Walsh TS, Pearse RM, Lone NI(2019). The association between ICU admission and emergency hospital readmission following emergency general surgery. Journal of the Intensive Care Society vol. 20, (4) 316-326.

Macdonald N, Pearse RM, Murray PT, Inzitari R, Doran P, Prowle JR(2019). The role of goal-directed therapy in the prevention of acute kidney injury after major gastrointestinal surgery: Substudy of the OPTIMISE trial. European Journal of Anaesthesiology vol. 36, (12) 924-932.

Yang F, Walker S, Richardson G, Stephens T, Phull M, Thompson A, Pearse RM, Enhanced Peri-Operative Care for High-risk patients (EPOCH) trial group(2019). Cost-effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery: Learning from 15,856 patients. International Journal of Surgery vol. 72, 25-31.

Peden CJ, Stephens T, Martin G, Kahan BC, Thomson A, Everingham K, Kocman D, Lourtie J et al.(2019). A national quality improvement programme to improve survival after emergency abdominal surgery: the EPOCH stepped-wedge cluster RCT.

Biccard BM, Bishop D, Dyer RA, Pearse RM(2019). Anaesthesia providers and maternal mortality in Africa – Authors' reply. The Lancet Global Health vol. 7, (10)

Murray D, Pearse RM, Quiney N(2019). Towards a coordinated national strategy to improve survival after emergency laparotomy. British Journal of Anaesthesia vol. 123, (4) 399-401.

Cashmore R, Fowler A, Pearse R(2019). Post-operative intensive care: is it really necessary?. Intensive Care Medicine

Haines R, Zolfaghari P, Wan Y, PUTHUCHEARY Z, Pearse R, Prowle J(2019). Elevated urea to creatinine ratio provides a biochemical signature of muscle catabolism and persistent critical illness after major trauma. Intensive Care Medicine

Stephens TJ, Peden CJ, Haines R, Grocott MPW, Murray D, Cromwell D, Johnston C, Hare S et al.(2019). Hospital-level evaluation of the effect of a national quality improvement programme: time-series analysis of registry data. BMJ Quality and Safety

Stephens T, Pearse RM(2019). Learning from the EPOCH trial (Editorial). What we have learnt from a trial of an intervention to improve survival following emergency laparotomy. Anaesthesia Critical Care and Pain Medicine vol. 38, (4) 321-322.

The Vascular Events in Noncardiac Surgery Patients Cohort Evaluation (VISION) Study Investigators(2019). Association between complications and death within 30 days after noncardiac surgery. Canadian Medical Association Journal vol. 191, (30) E830-E837.

Peden CJ, Stephens T, Martin G, Kahan BC, Thomson A, Rivett K, Wells D, Richardson G et al.(2019). Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery (EPOCH): a stepped-wedge cluster-randomised trial. The Lancet vol. 393, (10187) 2213-2221.

Fowler AJ, ABBOTT T, PROWLE J, PEARSE R(2019). Age of patients undergoing surgery. British Journal of Surgery

Haller G, Bampoe S, Cook T, Fleisher LA, Grocott MPW, Neuman M, Story D, Myles PS et al.(2019). Systematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine initiative: clinical indicators. British Journal of Anaesthesia

Pearse R(2019). Post-surgery mortality in Poland – Author's reply. The Lancet vol. 393, (10185) 2034-2035.

ABBOTT TEF, PEARSE RM, beattie S, Phull M, Beilstein C, Raj A, Grocott M, Cuthbertson B et al.(2019). Chronotropic incompetence and myocardial injury after non-cardiac surgery: planned secondary analysis of a prospective observational international cohort study. BJA: British Journal of Anaesthesia vol. 123, (1) 17-26.

Kocman D, Stöckelová T, Pearse R, Martin G(2019). Neither magic bullet nor a mere tool: negotiating multiple logics of the checklist in healthcare quality improvement. Sociology of Health and Illness vol. 41, (4) 755-771.

Wijeysundera DN, Cuthbertson BH, Pearse RM, Myles PS(2019). Functional capacity and preoperative risk evaluation – Authors' reply. The Lancet vol. 393, (10181) 1593-1594.

Bishop D, Dyer RA, Maswime S, Rodseth RN, van Dyk D, Kluyts HL, Tumukunde JT, Madzimbamuto FD et al.(2019). Maternal and neonatal outcomes after caesarean delivery in the African Surgical Outcomes Study: a 7-day prospective observational cohort study. The Lancet Global Health vol. 7, (4) e513-e522.

Edwards MR, Forbes G, MacDonald N, Berdunov V, Mihaylova B, Dias P, Thomson A, Grocott MP et al.(2019). Optimisation of Perioperative Cardiovascular Management to Improve Surgical Outcome II (OPTIMISE II) trial: study protocol for a multicentre international trial of cardiac output-guided fluid therapy with low-dose inotrope infusion compared with usual care in patients undergoing major elective gastrointestinal surgery. BMJ Open vol. 9, (1) e023455-e023455.

Ryan EG, Harrison EM, Pearse RM, Gates S(2019). Perioperative haemodynamic therapy for major gastrointestinal surgery: The effect of a Bayesian approach to interpreting the findings of a randomised controlled trial. BMJ Open vol. 9, (3)

Manou-Stathopoulou V, Abbott TEF, May SM, Cuthbertson BH, Wijeysundera DN, Pearse RM, Ackland GL (2019). Perioperative plasma cortisol levels and myocardial injury after non-cardiac surgery. BRITISH JOURNAL OF ANAESTHESIA. vol. 122, E45-E46.

May SM, Abbott TEF, Del Arroyo AG, Cuthbertson BH, Wijeysundera DN, Pearse RM, Ackland GL (2019). Serum microRNAs and perioperative myocardial injury. BRITISH JOURNAL OF ANAESTHESIA. vol. 122, E45-E45.

ABBOTT TEF, PEARSE R(2019). Depth of Anesthesia and Postoperative Delirium. JAMA - Journal of the American Medical Association vol. 321, (5) 459-460.

Biais M, Pearse R(2019). Perioperative haemodynamic therapy: Why are recommendations not being adopted?. Anaesthesia Critical Care and Pain Medicine vol. 38, (1) 5-7.

ABBOTT TEF, Greaves K, PEARSE RM, Writing committee for the International Surgical Outcomes Study (ISOS) group(2019). Prospective observational cohort study on grading the severity of postoperative complications in global surgery research. British Journal of Surgery vol. 106, e73-e80.

Abbott TEF, Pearse RM, Cuthbertson BH, Wijeysundera DN, Ackland GL(2019). Cardiac vagal dysfunction and myocardial injury after non-cardiac surgery: a planned secondary analysis of the measurement of Exercise Tolerance before surgery study. British Journal of Anaesthesia

Ackland GL, Abbott TEF, Minto G, Clark M, Owen T, Prabhu P, May SM, Reynolds JA et al.(2019). Correction: Heart rate recovery and morbidity after noncardiac surgery: Planned secondary analysis of two prospective, multi-centre, blinded observational studies (PLoS ONE (2019) 14:8 (e0221277) DOI: 10.1371/journal.pone.0221277). PLoS ONE vol. 14, (12)

Ackland GL, Abbott TEF, Minto G, Clark M, Owen T, Prabhu P, May SM, Reynolds JA et al.(2019). Heart rate recovery and morbidity after noncardiac surgery: Planned secondary analysis of two prospective, multi-centre, blinded observational studies. PLoS ONE vol. 14, (8)

Wan Y, Patel A, Achary C, Hewson R, Phull M, Pearse R (2019). International Surgical Outcomes Study (ISOS) sub-study: post-operative infection (Statistical Analysis Plan).

Barnes J, Hunter J, Harris S, Shankar-Hari M, Diouf E, Jammer I, Kalkman C, Klein AA et al.(2019). Systematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative: infection and sepsis. British Journal of Anaesthesia

Shulman MA, Cuthbertson BH, Wijeysundera DN, Pearse RM, Thompson B, Torres E, Ambosta A, Wallace S et al.(2019). Using the 6-minute walk test to predict disability-free survival after major surgery. British Journal of Anaesthesia vol. 122, (1) 111-119.

Stephens TJ, Peden CJ, Pearse RM, Shaw SE, Abbott TEF, Jones EL, Kocman D, Martin G(2018). Correction: Improving care at scale: Process evaluation of a multi-component quality improvement intervention to reduce mortality after emergency abdominal surgery (EPOCH trial). [Implement Sci. (2018), 13 (142)] DOI: 10.1186/s13012-018-0823-9. Implementation Science vol. 13, (1)

Simonis FD, Barbas CSV, Artigas-Raventós A, Canet J, Determann RM, Anstey J, Hedenstierna G, Hemmes SNT et al.(2018). Potentially modifiable respiratory variables contributing to outcome in ICU patients without ARDS: a secondary analysis of PRoVENT. Annals of Intensive Care vol. 8, (1)

Kluyts HL, le Manach Y, Munlemvo DM, Madzimbamuto F, Basenero A, Coulibaly Y, Rakotoarison S, Gobin V et al.(2018). The ASOS Surgical Risk Calculator: development and validation of a tool for identifying African surgical patients at risk of severe postoperative complications. British Journal of Anaesthesia vol. 121, (6) 1357-1363.

Stephens TJ, Peden CJ, Pearse RM, Shaw SE, Abbott TEF, Jones E, Kocman D, Martin G et al.(2018). Improving care at scale: Process evaluation of a multi-component quality improvement intervention to reduce mortality after emergency abdominal surgery (EPOCH trial). Implementation Science vol. 13, (1)

Chaudery H, MacDonald N, Ahmad T, Chandra S, Tantri A, Sivasakthi V, Mansor M, Matos R et al.(2018). Acute Kidney Injury and Risk of Death After Elective Surgery: Prospective Analysis of Data From an International Cohort Study. Anesth Analg

de Nadal M, Pérez-Hoyos S, Montejo-González JC, Pearse R, Aldecoa C(2018). Intensive care admission and hospital mortality in the elderly after non-cardiac surgery. Medicina Intensiva vol. 42, (8) 463-472.

Fowler AJ, AHMAD T, ABBOTT T, TORRANCE H, PEARSE R, Wouters PF, De Hert S, Lobo SM et al.(2018). Association of preoperative anaemia with postoperative morbidity and mortality: an observational cohort study in low-, middle-, and high-income countries. British Journal of Anaesthesia vol. 121, (6) 1227-1235.

Bloom B, Thomas S, Ahrensberg JM, Weaver R, Fowler A, Bestwick J, Harris T, Pearse R(2018). A systematic review and meta-analysis of return to work after mild Traumatic brain injury. Brain Inj1-14.

Ackland GL, Abbott TEF, Cain D, Edwards MR, Sultan P, Karmali SN, Fowler AJ, Whittle JR et al.(2018). Preoperative systemic inflammation and perioperative myocardial injury: prospective observational multicentre cohort study of patients undergoing non-cardiac surgery. British Journal of Anaesthesia

TORRANCE H, LONGBOTTOM R, VIVIAN M, Lalabekyan B, ABBOTT TEF, ACKLAND GL, HINDS CJ, PEARSE RM et al.(2018). Post-operative immune suppression is mediated via reversible, Interleukin-10 dependent pathways in circulating monocytes following major abdominal surgery. PLoS ONE vol. 13, (9)

Hewitt Smith A, Bulamba F, Olupot C, Musana F, Ochieng JP, Lipnick MS, Pearse RM(2018). Surgical outcomes in eastern Uganda: A one-year cohort study. Southern African Journal of Anaesthesia and Analgesia vol. 24, (5) 122-127.

Greenberg L, Jairath V, Pearse R, Kahan BC(2018). Prespecification of statistical analysis approaches in published clinical trial protocols was inadequate. Journal of Clinical Epidemiology vol. 101, 53-60.

Neto AS, da Costa LGV, Hemmes SNT, Canet J, Hedenstierna G, Jaber S, Hiesmayr M, Hollmann MW et al.(2018). The LAS VEGAS risk score for prediction of postoperative pulmonary complications: An observational study. European journal of anaesthesiology vol. 35, (9) 691-701.

Ackland GL, Abbott TF, Pearse RM, Surg VEN-C (2018). Preoperative systemic inflammation and myocardial injury in non-cardiac surgery. BRITISH JOURNAL OF ANAESTHESIA. vol. 121, E20-E21.

Gillies MA, Pearse R, Chew MS(2018). Peri-operative goal-directed therapy. European Journal of Anaesthesiology vol. 35, (7) 467-468.

Pearse RM, Hopkins PM(2018). Where audit meets science: role of reporting and recommendations guidelines in service evaluations. British Journal of Anaesthesia vol. 121, (1) 118-120.

Wijeysundera D, PEARSE R, shulman M, ABBOTT TEF, Torres E, Ambosta A, Bernard C, Granton J et al.(2018). Assessment of functional capacity before major non-cardiac surgery: an international, prospective cohort study. Lancet vol. 391, (10140) 2631-2640.

WALKER S, ABBOTT TEF, Brown K, PEARSE R, ACKLAND G(2018). Perioperative management of angiotensin-converting enzyme inhibitors and/or angiotensin receptor blockers: a survey of perioperative medicine practitioners. PeerJ

Lurati Buse G, Manns B, Lamy A, Guyatt G, Polanczyk CA, Chan MTV, Wang CY, Villar JC et al.(2018). Troponin T monitoring to detect myocardial injury after noncardiac surgery: a cost–consequence analysis. Canadian Journal of Surgery vol. 61, (3) 185-194.

Walker S, Abbott T, Brown K, Pearse R, Ackland G (2018). Contemporary perioperative management of ACE-inhibitors and angiotensin receptor blockers. BRITISH JOURNAL OF ANAESTHESIA. vol. 120, E24-E25.

Vincent JL, Einav S, Pearse R, Jaber S, Kranke P, Overdyk FJ, Whitaker DK, Gordo F et al.(2018). Improving detection of patient deterioration in the general hospital ward environment. European Journal of Anaesthesiology vol. 35, (5) 325-333.

Kahan BC, Morris TP, Harris E, Pearse R, Hooper R, Eldridge S(2018). Re-randomization increased recruitment and provided similar treatment estimates as parallel designs in trials of febrile neutropenia. Journal of Clinical Epidemiology vol. 97, 14-19.

Buggy DJ, Freeman J, Johnson MZ, Leslie K, Riedel B, Sessler DI, Kurz A, Gottumukkala V et al.(2018). Systematic review and consensus definitions for standardised endpoints in perioperative medicine: postoperative cancer outcomes. British Journal of Anaesthesia

ABBOTT TEF, Fowler A, Pelosi P, Garna de Abru M, Moller A, Canet J, Creagh-Brown B, Mythen M et al.(2018). A systematic review and consensus definitions for standardised end-points in perioperative medicine: pulmonary complications. British Journal of Anaesthesia

Wijeysundera DN, Pearse R, Shulman M, Abbott T, Grocott MP, Myles P, Cuthbertson B (2018). ASSESSMENT OF FUNCTIONAL CAPACITY BEFORE MAJOR ELECTIVE NONCARDIAC SURGERY: AN INTERNATIONAL MULTICENTER PROSPECTIVE COHORT STUDY. ANESTHESIA AND ANALGESIA. vol. 126, 585-587.

Yeung J, Gillies MA, Pearse RM(2018). Pragmatic trials in peri-operative medicine: why, when and how?. Anaesthesia

PROWLE JR(2018). Acute Kidney Injury in Trauma Patients Admitted to Critical Care: Development and Validation of a Diagnostic Prediction Model. Scientific Reports

PEARSE RM(2018). Perioperative patient outcomes in the African Surgical Outcomes Study: a 7-day prospective observational cohort study. Lancet

ackland GL, ABBOTT T, Pearse RM, Karmali S, Whittle J, Minto G(2018). Arterial pulse pressure and postoperative morbidity in high-risk surgical patients. British Journal of Anaesthesia vol. 120, (1) 94-100.

ABBOTT T, Ahmad T, Phull M, Fowler A, Hewson R, Biccard B, Chew M, Gillies M et al.(2018). The surgical safety checklist and patient outcomes after surgery: a prospective observational cohort study, systematic review and meta-analysis. British Journal of Anaesthesia vol. 120, (1) 146-155.

MacDonald N, Pearse RM(2017). Are we close to the ideal intravenous fluid?. British Journal of Anaesthesia vol. 119, i63-i71.

Moppett IK, Pearse RM(2017). Evidence-based medicine: The clue is in the name. British Journal of Anaesthesia vol. 119, (6) 1084-1086.

ABBOTT T, pearse RM, Archbold RA, Ahmad T, Niebrzegowska E, Wragg A, Rodseth R, Devereaux PJ et al.(2017). A Prospective International Multicentre Cohort Study of Intraoperative Heart Rate and Systolic Blood Pressure and Myocardial Injury After Noncardiac Surgery: Results of the VISION Study. Anesthesia and Analgesia vol. 126, (6) 1936-1945.

Vellinga NAR, Boerma EC, Koopmans M, Donati A, Dubin A, Shapiro NI, Pearse RM, van der Voort PHJ et al.(2017). Mildly elevated lactate levels are associated with microcirculatory flow abnormalities and increased mortality: A microSOAP post hoc analysis. Critical Care vol. 21, (1)

Ghaffar S, Pearse RM, Gillies MA(2017). ICU admission after surgery: Who benefits?. Current Opinion in Critical Care vol. 23, (5) 424-429.

Gillies MA, Sander M, Shaw A, Wijeysundera DN, Myburgh J, Aldecoa C, Jammer I, Lobo SM et al.(2017). Current research priorities in perioperative intensive care medicine. Intensive Care Medicine vol. 43, (9) 1173-1186.

Szakmany T, Ditai J, Kirov M, Protsenko D, Osinaike B, Venara A, Demartines N, Hubner M et al.(2017). In-hospital clinical outcomes after upper gastrointestinal surgery: Data from an international observational study. EJSO - European Journal of Surgical Oncology

Schultz MJ, Hemmes SNT, Neto AS, Binnekade JM, Canet J, Hedenstierna G, Jaber S, Hiesmayr M et al.(2017). Epidemiology, practice of ventilation and outcome for patients at increased risk of postoperative pulmonary complications: LAS VEGAS - An observational study in 29 countries. European Journal of Anaesthesiology vol. 34, (8) 492-507.

Chaudery H, MacDonald N, Pearse RM, Prowle JR (2017). Global Incidence and Associations of Acute Kidney Injury in the International Surgical Outcomes Study (ISOS). vol. 119, is. 2, pp. E28-E28.

Ahmad T, Bouwman RA, Grigoras I, Aldecoa C, Hofer C, Hoeft A, Holt P, Fleisher LA et al.(2017). Use of failure-to-rescue to identify international variation in postoperative care in low-, middle- and high-income countries: A 7-day cohort study of elective surgery. British Journal of Anaesthesia vol. 119, (2) 258-266.

ABBOTT T, Pearse R, Dobbs TD, Harrison EM, Gillies MA, Fowler AJ(2017). Frequency of surgical treatment and related hospital procedures in the United Kingdom: A national ecological study using hospital episode statistics. British Journal Of Anaesthesia vol. 119, (2) 249-257.

ABBOTT T, pearse R, ahmad T, ackland G(2017). Association between preoperative pulse pressure and perioperative myocardial injury: an international observational cohort study of patients undergoing non-cardiac surgery. British Journal Of Anaesthesia vol. 119, (1) 78-86.

ABBOTT T, Lee A, Pearse R, Ackland G, Minto G(2017). Elevated preoperative heart rate is associated with cardiopulmonary and autonomic impairment in high-risk surgical patients. British Journal Of Anaesthesia vol. 119, (1) 87-94.

Martin GP, Kocman D, Stephens T, Peden CJ, Pearse RM, This study was carried out as part of a wider randomised controlled trial, EPOCH(2017). Pathways to professionalism? Quality improvement, care pathways, and the interplay of standardisation and clinical autonomy. Sociol Health Illn

Gillies MA, Lone NI, Pearse RM, Haddow C, Smyth L, Parks RW, Walsh TS, Harrison EM(2017). Effect of day of the week on short- and long-term mortality after emergency general surgery. British Journal of Surgery vol. 104, (7) 936-945.

ABBOTT T, Pearse RM(2017). Saving money: an ideal driver for improved perioperative care?. Anaesth Crit Care Pain Med vol. 36, (3) 147-148.

Writing Committee for the VISION Study Investigators, Devereaux PJ, Biccard BM, Sigamani A, Xavier D, Chan MTV, Srinathan SK, Walsh M et al.(2017). Association of Postoperative High-Sensitivity Troponin Levels With Myocardial Injury and 30-Day Mortality Among Patients Undergoing Noncardiac Surgery. JAMA vol. 317, (16) 1642-1651.

Kahan BC, Koulenti D, Arvaniti K, Beavis V, Campbell D, Chan M, Moreno R, Pearse RM et al.(2017). Critical care admission following elective surgery was not associated with survival benefit: prospective analysis of data from 27 countries. Intensive Care Med vol. 43, (7) 971-979.

O'Connor ME, Hewson RW, Kirwan CJ, Ackland GL, Pearse RM, Prowle JR(2017). Acute kidney injury and mortality 1 year after major non-cardiac surgery. British Journal of Surgery

Pearse RM, ABBOTT T, Haslop R, Ahmad T, Kahan BC, Filippini C, Rhodes A, Ranieri M(2017). Prevention of Respiratory Insufficiency after Surgical Management (PRISM) trial: report of the protocol for a pragmatic randomised controlled trial of Continuous Positive Airway Pressure (CPAP) to prevent respiratory complications and improve survival following major abdominal surgery. Minerva Anestesiol vol. 83, (2) 175-182.

Bloom BM, Kinsella K, Pott J, Patel HC, Harris T, Lecky F, Pearse R(2017). Short-term neurocognitive and symptomatic outcomes following mild traumatic brain injury: A prospective multi-centre observational cohort study. Brain Inj vol. 31, (3) 304-311.

Davenport RA, Guerreiro M, Frith D, Rourke C, Platton S, Cohen M, Pearse R, Thiemermann C et al.(2017). Activated Protein C Drives the Hyperfibrinolysis of Acute Traumatic Coagulopathy. Anesthesiology vol. 126, (1) 115-127.

Skinner DL, De Vasconcellos K, Wise R, Esterhuizen TM, Fourie C, Mahomed AG, Gopalan PD, Joubert I et al.(2017). Critical care admission of South African (SA) surgical patients: Results of the sa surgical outcomes study. South African Medical Journal vol. 107, (5) 411-419.

Gillies MA, Harrison EM, Pearse RM, Garrioch S, Haddow C, Smyth L, Parks R, Walsh TS et al.(2017). Intensive care utilization and outcomes after high-risk surgery in Scotland: A population-based cohort study. British Journal of Anaesthesia vol. 118, (1) 123-131.

Neto AS, Barbas CSV, Simonis FD, Artigas-Raventós A, Canet J, Determann RM, Anstey J, Hedenstierna G et al.(2016). Epidemiological characteristics, practice of ventilation, and clinical outcome in patients at risk of acute respiratory distress syndrome in intensive care units from 16 countries (PRoVENT): an international, multicentre, prospective study. The Lancet Respiratory Medicine vol. 4, (11) 882-893.

Pearse R(2016). Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries. British Journal of Anaesthesia vol. 117, (5) 601-609.

Prowle JR, Kam EPY, Ahmad T, Smith NCE, Protopapa K, Pearse RM(2016). Preoperative renal dysfunction and mortality after non-cardiac surgery. The British journal of surgery vol. 103, (10) 1316-1325.

Longbottom ER, Torrance HDT, Owen HC, Fragkou PC, Hinds CJ, Pearse RM, O'Dwyer MJ(2016). Features of Postoperative Immune Suppression Are Reversible with Interferon Gamma and Independent of Interleukin-6 Pathways. Annals of Surgery vol. 264, (2) 370-377.

Abbott TEF, Ackland GL, Archbold RA, Wragg A, Kam E, Ahmad T, Khan AW, Niebrzegowska E et al.(2016). Preoperative heart rate and myocardial injury after non-cardiac surgery: results of a predefined secondary analysis of the VISION study. British Journal of Anaesthesia vol. 117, (2) 172-181.

Torrance HDT, Pearse RM, O'Dwyer MJ(2016). Does major surgery induce immune suppression and increase the risk of postoperative infection?. Curr Opin Anaesthesiol vol. 29, (3) 376-383.

Bloom BM, Maimaris C, Lecky F, Pearse R(2016). Letter in Response to 'Classification of Traumatic Brain Injury Severity Using Informed Data Reduction in a Series of Binary Classifier Algorithms'. IEEE Transactions on Neural Systems and Rehabilitation Engineering vol. 24, (5)

Jawad M, Baigi A, Oldner A, Pearse RM, Rhodes A, Seeman-Lodding H, Chew MS(2016). Swedish surgical outcomes study (SweSOS). European Journal of Anaesthesiology vol. 33, (5) 317-325.

Wijeysundera DN, Pearse RM, Shulman MA(2016). Correction. Measurement of Exercise Tolerance before Surgery (METS) study: a protocol for an international multicenter prospective cohort study of cardiopulmonary exercise testing prior to major noncardiac surgery. BMJ Open vol. 6, (4)

O¿Connor ME, Kirwan CJ, Pearse RM, Prowle JR(2016). Incidence and associations of acute kidney injury after major abdominal surgery. Intensive Care Medicine vol. 42, (4) 1-10.

Gillies MA, Pearse RM(2016). Intensive Care after High-risk Surgery: What's in a Name?. Anesthesiology vol. 124, (4) 761-762.

Wijeysundera DN, Pearse RM, Shulman MA, Abbott TEF, Torres E, Croal BL, Granton JT, Thorpe KE et al.(2016). Measurement of Exercise Tolerance before Surgery (METS) study: a protocol for an international multicentre prospective cohort study of cardiopulmonary exercise testing prior to major non-cardiac surgery. BMJ Open vol. 6, (3) e010359-e010359.

Ozdemir BA, Sinha S, Karthikesalingam A, Poloniecki JD, Pearse RM, Grocott MPW, Thompson MM, Holt PJE(2016). Mortality of emergency general surgical patients and associations with hospital structures and processes. British Journal of Anaesthesia vol. 116, (1) 54-62.

Cecconi M, Hochrieser H, Chew M, Grocott M, Hoeft A, Hoste A, Jammer I, Posch M et al.(2016). Preoperative abnormalities in serum sodium concentrations are associated with higher in-hospital mortality in patients undergoing major surgery. British Journal of Anaesthesia vol. 116, (1) 63-69.

Garrioch S, Lone N, Walsh T, Parks R, Pearse R, Smyth L, Haddow C, Gillies M (2016). Short and long term outcome, critical care usage and predictors of mortality following emergency laparotomy in Scotland. ANAESTHESIA. vol. 71, 64-64.

Abbott T, Ackland GL, Wragg A, Rodseth R, Archbold A, Pearse RM(2015). Association between intraoperative heart rate and postoperative myocardial injury in patients following non-cardiac surgery. Intensive Care Med Exp vol. 3, (Suppl 1) A751-A751.

Abbott T, Ackland G, Wragg A, Archbold A, Devereaux P, Pearse R (2015). Association of preoperative heart rate with postoperative myocardial injury. BRITISH JOURNAL OF ANAESTHESIA. vol. 115, E958-E959.

Raja M, Torrance H, Longbottom ER, Stroud AJ, Vivian ME, Zolfaghari PS, Pearse RM, Hinds CJ et al.(2015). Long-Term Follow-Up of Sepsis Induced Immunoparalysis. Intensive Care Med Exp vol. 3, (Suppl 1)

Longbottom ER, Torrance H, Owen HC, Hinds CJ, Pearse RM, O'Dwyer MJ(2015). Post-operative immune suppression is reversible with interferon gamma and independent of IL-6 pathways. Intensive Care Med Exp vol. 3, (Suppl 1)

Gillies MA, Power GS, Harrison DA, Fleming A, Cook B, Walsh TS, Pearse RM, Rowan KM(2015). Regional variation in critical care provision and outcome after high-risk surgery. Intensive Care Medicine vol. 41, (10) 1809-1816.

Fowler AJ, Ahmad T, Phull MK, Allard S, Gillies MA, Pearse RM(2015). Meta-analysis of the association between preoperative anaemia and mortality after surgery. British Journal of Surgery vol. 102, (11) 1314-1324.

AHMAD T(2015). Variation in haemodynamic monitoring for major surgery in European nations: secondary analysis of the EuSOS dataset. Perioperative Medicine vol. 4, (8)

Gillies MA, Shah AS, Mullenheim J, Tricklebank S, Owen T, Antonelli J, Strachan F, Mills NL et al.(2015). Perioperative myocardial injury in patients receiving cardiac output-guided haemodynamic therapy: a substudy of the OPTIMISE Trial. British journal of anaesthesia vol. 115, (2) 227-233.

Abbott T, Rodseth R, Le Manach Y, Ackland G, Archbold A, Wragg A, Devereaux P, Pearse R (2015). Association between preoperative resting heart rate and postoperative myocardial injury in patients undergoing non-cardiac surgery. ANAESTHESIA. vol. 70, 28-28.

van Zaane B, van Klei WA, Buhre WF, Bauer P, Boerma EC, Hoeft A, Metnitz P, Moreno RP et al.(2015). Nonelective surgery at night and in-hospital mortality: Prospective observational data from the European Surgical Outcomes Study. European journal of anaesthesiology vol. 32, (7) 477-485.

Vincent J-L, Pelosi P, Pearse R, Payen D, Perel A, Hoeft A, Romagnoli S, Ranieri VM et al.(2015). Perioperative cardiovascular monitoring of high-risk patients: a consensus of 12. CRITICAL CARE vol. 19, Article ARTN 224,

Jammer I, Ahmad T, Aldecoa C, Koulenti D, Goranovi¿ T, Grigoras I, Mazul-Sunko B, Matos R et al.(2015). Point prevalence of surgical checklist use in Europe: Relationship with hospital mortality. British Journal of Anaesthesia vol. 114, (5) 801-807.

Bloom BM, Maimaris C, Lecky F, Pearse R(2015). Letter in response to 'Classification algorithms for the identification of structural injury in TBI using brain electrical activity'. Computers in biology and medicine

Freund Y, Bloom B, Bokobza J, Baarir N, Laribi S, Harris T, Navarro V, Bernard M et al.(2015). Predictive value of S100-B and copeptin for outcomes following seizure: the BISTRO International Cohort Study. PloS one vol. 10, (4) e0122405-e0122405.

Torrance HD, Brohi K, Pearse RM, Mein CA, Wozniak E, Prowle JR, Hinds CJ, O'Dwyer MJ(2015). Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured polytrauma patients. Annals of Surgery vol. 261, (4) 751-759.

Torrance HD, Brohi K, Pearse RM, Mein CA, Wozniak E, Prowle JR, Hinds CJ, O¿Dwyer MJ(2015). Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured polytrauma patients. Ann Surg vol. 261, (4) 751-759.

MacDonald N, Ahmad T, Mohr O, Kirk-Bayley J, Moppett I, Hinds CJ, Pearse RM(2015). Dynamic preload markers to predict fluid responsiveness during and after major gastrointestinal surgery: An observational substudy of the OPTIMISE trial. British Journal of Anaesthesia vol. 114, (4) 598-604.

Ackland GL, Cecconi M, Pearse RM(2015). Individualised targeted haemodynamic therapy in high-risk surgical patients - authors' reply. The Lancet. Respiratory medicine vol. 3, (4) e14-e15.

Al-Khafaji A, Elder M, Lebovitz DJ, Murugan R, Souter M, Stuart S, Wahed AS, Keebler B et al.(2015). Protocolized fluid therapy in brain-dead donors: the multicenter randomized MOnIToR trial. Intensive Care Medicine vol. 41, (3) 418-426.

Jammer I, Wickboldt N, Sander M, Smith A, Schultz MJ, Pelosi P, Leva B, Rhodes A et al.(2015). Standards for definitions and use of outcome measures for clinical effectiveness research in perioperative medicine: European Perioperative Clinical Outcome (EPCO) definitions: a statement from the ESA-ESICM joint taskforce on perioperative outcome measures. Eur J Anaesthesiol vol. 32, (2) 88-105.

Moreno RP, Pearse R, Rhodes A(2015). American Society of Anesthesiologists Score: Still useful after 60 years? Results of the EuSOS Study. Revista Brasileira de Terapia Intensiva vol. 27, (2) 105-112.

Torrance HD, Vivian ME, Brohi K, Prowle JR, Pearse RM, Owen HC, Hinds CJ, O'Dwyer MJ(2015). Changes in gene expression following trauma are related to the age of transfused packed red blood cells. J Trauma Acute Care Surg vol. 78, (3) 535-542.

Sadique Z, Harrison DA, Grieve R, Rowan KM, Pearse RM, OPTIMISE study group(2015). Cost-effectiveness of a cardiac output-guided haemodynamic therapy algorithm in high-risk patients undergoing major gastrointestinal surgery. Perioper Med (Lond) vol. 4,

Owen HC, Torrance HDT, Jones TF, Pearse RM, Hinds CJ, Brohi K, O'Dwyer MJ(2015). Epigenetic regulatory pathways involving microRNAs may modulate the host immune response following major trauma. Journal of Trauma and Acute Care Surgery vol. 79, (5) 766-772.

Ackland GL, Iqbal S, Paredes LG, Toner A, Lyness C, Jenkins N, Bodger P, Karmali S et al.(2015). Individualised oxygen delivery targeted haemodynamic therapy in high-risk surgical patients: A multicentre, randomised, double-blind, controlled, mechanistic trial. The Lancet Respiratory Medicine vol. 3, (1) 33-41.

Ackland GL, Igbal S, Paredes LG, Toner A, Lyness C, Jenkins N, Bodger P, Karmali S et al.(2015). Individualised oxygen delivery targeted haemodynamic therapy in high-risk surgical patients: a multicentre, randomised, double-blind, controlled, mechanistic trial. LANCET RESPIRATORY MEDICINE vol. 3, (1) 33-41.

Vellinga NAR, Boerma EC, Koopmans M, Donati A, Dubin A, Shapiro NI, Pearse RM, Machado FR et al.(2015). International study on microcirculatory shock occurrence in acutely Ill patients. Critical Care Medicine vol. 43, (1) 48-56.

Pearse RM, Wijeysundera DN(2015). Steroids for cardiac surgery: Has the story finally ended?. The Lancet vol. 386, (10000) 1215-1216.

Pearse RM(2015). The whole truth and nothing but the truth: the need for full reporting of randomised trials. Perioperative medicine (London, England) vol. 4, 7-7.

Pearse RM(2014). Effect of a Perioperative, Cardiac Output-Guided Hemodynamic Therapy Algorithm on Outcomes Following Major Gastrointestinal Surgery: A Randomized Clinical Trial and Systematic Review (vol 311, pg 2181, 2014). JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION vol. 312, (14) 1473-1473.

Pearse RM, MacDonald N, Grocott MPW, OPTIMISE Study Group(2014). Use of hemodynamic algorithm after gastrointestinal surgery--reply. JAMA vol. 312, (14)

Baron DM, Hochrieser H, Posch M, Metnitz B, Rhodes A, Moreno RP, Pearse RM, Metnitz P et al.(2014). Preoperative anaemia is associated with poor clinical outcome in non-cardiac surgery patients. Br J Anaesth vol. 113, (3) 416-423.

Vivian M, Torrance HDT, Pearse R, Brohi K, Hinds CJ, O'Dwyer MJ (2014). THE AGE OF TRANSFUSED PACKED RED BLOOD CELLS CORRELATES WITH THE DEGREE OF IMMUNOSUPPRESSION AS ASSESSED BY GENE EXPRESSION PATTERNS IN SEVERELY INJURED TRAUMA PATIENTS. INTENSIVE CARE MEDICINE. vol. 40, S20-S20.

Torrance HDT, Brohi K, Pearse RM, Mein CA, Wozniak E, Prowle JR, Hinds CJ, O'Dwyer MJ (2014). Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured polytrauma patients. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. vol. 22,

Prowle JR, Kolic I, Purdell-Lewis J, Taylor R, Pearse RM, Kirwan CJ(2014). Serum creatinine changes associated with critical illness and detection of persistent renal dysfunction after AKI. Clin J Am Soc Nephrol vol. 9, (6) 1015-1023.

Pearse RM, Harrison DA, MacDonald N, Gillies MA, Blunt M, Ackland G, Grocott MPW, Ahern A et al.(2014). Effect of a perioperative, cardiac output-guided hemodynamic therapy algorithm on outcomes following major gastrointestinal surgery: a randomized clinical trial and systematic review. JAMA vol. 311, (21) 2181-2190.

Fragkou P, Torrance H, Ackland G, Hinds C, Pearse R, O'Dwyer MJ (2014). Major gastrointestinal surgery is associated with a specific gene expression profile that is quantitatively associated with infectious complications. EUROPEAN JOURNAL OF ANAESTHESIOLOGY. vol. 31, 14-14.

Fragkou P, Prowle J, Ackland G, Hinds C, Pearse R, O'Dwyer MJ (2014). Perioperative blood transfusion is associated with a characteristic immune response, excess infectious complications and death in patients undergoing scheduled major gastrointestinal surgery. EUROPEAN JOURNAL OF ANAESTHESIOLOGY. vol. 31, 91-91.

Jawad M, Pearse R, Rhodes A, Seeman-Lodding H, Baigi A, Chew MS, Grp SS (2014). Swedish Surgical Outcome Study (SweSOS), a sub study of the European Surgical Outcomes Study (EuSOS). Characteristics and outcome of the Swedish subset of EuSOS to identify the predictors of short-and long-term mortality in Sweden. Analytical, descriptive and prospective cohort study. EUROPEAN JOURNAL OF ANAESTHESIOLOGY. vol. 31, 248-249.

Reynolds TE, Pearse RM(2014). Cardiac troponins in sepsis: an indication for echocardiography?*. Crit Care Med vol. 42, (4) 975-976.

James S, Jhanji S, Smith A, O'Brien G, Fitzgibbon M, Pearse RM(2014). Comparison of the prognostic accuracy of scoring systems, cardiopulmonary exercise testing, and plasma biomarkers: a single-centre observational pilot study. Br J Anaesth vol. 112, (3) 491-497.

Torrance HDT, Brohi K, Pearse RM, Mein CA, Wozniak E, Prowle JR, Hinds CJ, O¿Dwyer MJ(2014). Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured polytrauma patients. Scandinavian journal of trauma, resuscitation and emergency medicine vol. 22, (Suppl 1) O7-O7.

Macdonald N, Pearse R (2014). Effect of a perioperative haemodynamic therapy algorithm on outcomes after major gastrointestinal surgery: a multi-centre randomized controlled trial. BRITISH JOURNAL OF ANAESTHESIA. vol. 112, 190P-190P.

Dreyer G, Tucker AT, Harwood SM, Pearse RM, Raftery MJ, Yaqoob MM(2014). Ergocalciferol and microcirculatory function in chronic kidney disease and concomitant vitamin d deficiency: an exploratory, double blind, randomised controlled trial. PLoS One vol. 9, (7)

Gillies MA, Habicher M, Jhanji S, Sander M, Mythen M, Hamilton M, Pearse RM(2014). Incidence of postoperative death and acute kidney injury associated with i.v. 6 hydroxyethyl starch use: systematic review and meta-analysis. BRITISH JOURNAL OF ANAESTHESIA vol. 112, (1) 25-34.

Botto F, Alonso-Coello P, Chan MTV, Villar JC, Xavier D, Srinathan S, Guyatt G, Cruz P et al.(2014). Myocardial Injury after Noncardiac Surgery: A Large, International, Prospective Cohort Study Establishing Diagnostic Criteria, Characteristics, Predictors, and 30-day Outcomes. Anesthesiology vol. 120, (3) 564-578.

Cullen MR, Jhanji S, Pearse RM, Fitzgibbon MC(2014). Neutrophil gelatinase-associated lipocalin and albuminuria as predictors of acute kidney injury in patients treated with goal-directed haemodynamic therapy after major abdominal surgery. Annals of Clinical Biochemistry vol. 51, (3) 392-399.

Kam E, Pearse R(2014). Patient outcome following major surgery. Paradise Lost and the Cosmological Revolution,

Lee GR, Jhanji S, Tarrant H, James S, Pearse RM, Fitzgibbon M(2014). Peri-operative troponin monitoring using a prototype high-sensitivity cardiac troponin I (hs-cTnI) assay: Comparisons with hs-cTnT and contemporary cTnI assays. Annals of Clinical Biochemistry vol. 51, (2) 258-268.

Fragkou PC, Torrance HD, Pearse RM, Ackland GL, Prowle JR, Owen HC, Hinds CJ, O'Dwyer MJ(2014). Perioperative blood transfusion is associated with a gene transcription profile characteristic of immunosuppression: a prospective cohort study. Crit Care vol. 18, (5) 014-0541.

Cannesson M, Pearse R(2014). Perioperative hemodynamic monitoring and goal directed therapy: From theory to practice.

Pearse R, Hoeft A, Moreno RP, Pelosi P, Rhodes A(2013). Mortality after surgery in Ireland - Authors' reply. Lancet vol. 382, (9910) 2063-2064.

Torrance HDT, Brohi K, Pearse RM, Fragkou P, Hinds CJ, O'Dwyer MJ (2013). BLOOD TRANSFUSION FOLLOWING SEVERE TRAUMA IS ASSOCIATED WITH THE DEVELOPMENT OF AN EARLY ANTI-INFLAMMATORY RESPONSE. INTENSIVE CARE MEDICINE. vol. 39, S386-S387.

Baron DM, Hochrieser H, Metnitz B, Rhodes A, Moreno RP, Pearse RM, Metnitz P, Investigators E (2013). PREOPERATIVE ANEMIA AND POLYCYTHEMIA ARE ASSOCIATED WITH A HIGHER IN-HOSPITAL MORTALITY IN NON-CARDIAC SURGERY PATIENTS. INTENSIVE CARE MEDICINE. vol. 39, S285-S285.

Cecconi M, Hochrieser H, Metnitz B, Moreno R, Pearse R, Metnitz P, Rhodes A, Investigators E (2013). PREOPERATVE SERUM SODIUM AND POSTOPERATIVE MORTALITY: A EUSOS SUBSTUDY. INTENSIVE CARE MEDICINE. vol. 39, S337-S338.

Walsh TS, Boyd JA, Watson D, Hope D, Lewis S, Krishan A, Forbes JF, Ramsay P et al.(2013). Restrictive versus liberal transfusion strategies for older mechanically ventilated critically ill patients: A randomized pilot trial. Critical Care Medicine vol. 41, (10) 2354-2363.

Pearse RM, van Zaane B, Moreno RP, Buhre WF, van Klei WA, Rhodes A, Med ESIC, Anaesthesiology ES (2013). START TIMES OF EMERGENCY SURGERY AND IN HOSPITAL MORTALITY: A COHORT STUDY ON THE EUSOS DATABASE COMPARING MORTALITY AFTER DAY SHIFT, EVENING SHIFT AND NIGHT SHIFT PROCTDURES. INTENSIVE CARE MEDICINE. vol. 39, S349-S349.

Diogo AC, Iannuccelli F, Rhodes A, Pearse R, Moreno R (2013). THE RELATIONSHIP BETWEEN THE ASA SCORE AND OUTCOME FROM SURGERY. RESULTS FROM THE EUSOS STUDY. INTENSIVE CARE MEDICINE. vol. 39, S349-S349.

Al-Khafaji A, Murugan R, Wahed AS, Lebovitz DJ, Souter MJ, Kellum JA, MOnIToR study investigators(2013). Monitoring Organ Donors to Improve Transplantation Results (MOnIToR) trial methodology. Crit Care Resusc vol. 15, (3) 234-240.

Reynolds T, Vivian-Smith A, Jhanji S, Pearse RM(2013). Observational study of the effects of age, diabetes mellitus, cirrhosis and chronic kidney disease on sublingual microvascular flow. Perioper Med (Lond) vol. 2, (1)

Bangash MN, Patel NSA, Benetti E, Collino M, Hinds CJ, Thiemermann C, Pearse RM(2013). Dopexamine can attenuate the inflammatory response and protect against organ injury in the absence of significant effects on hemodynamics or regional microvascular flow. Crit Care vol. 17, (2)

Prowle JR, Pearse RM(2013). Is it the end of the road for synthetic starches in critical illness?. BMJ (Online) vol. 346, (7900)

Retter A, Wyncoll D, Pearse R, Carson D, Mckechnie S, Stanworth S, Allard S, Thomas D et al.(2013). Guidelines on the management of anaemia and red cell transfusion in adult critically ill patients. British Journal of Haematology vol. 160, (4) 445-464.

Pearse R, Moreno RP, Bauer P, Pelosi P, Metnitz P, Spies C, Vallet B, Vincent JL et al.(2013). Mortality after surgery in Europe. The Lancet vol. 381, (9864) 370-371.

Ford SR, Pearse RM(2012). Do integrated care pathways have a place in critical care?. Curr Opin Crit Care vol. 18, (6) 683-687.

Pearse RM, Moreno RP, Bauer P, Pelosi P, Metnitz P, Spies C, Vallet B, Vincent J-L et al.(2012). Mortality after surgery in Europe: a 7 day cohort study. Lancet vol. 380, (9847) 1059-1065.

Vellinga NAR, Boerma EC, Koopmans M, Donati A, Dubin A, Shapiro NI, Pearse RM, Bakker J et al.(2012). Study design of the microcirculatory shock occurrence in acutely Ill patients (microSOAP): An international multicenter observational study of sublingual microcirculatory alterations in intensive care patients. Critical Care Research and Practice vol. 2012,

Young EL, Huddart S, Pearse RP, Karthikesalingam A, Hinchliffe RJ, Loftus IM, Thompson MM, Holt PJE(2012). Reply to 'Comment on a systematic review of the role of cardiopulmonary exercise testing in vascular surgery'. European Journal of Vascular and Endovascular Surgery vol. 44, (3) 350-351.

Pearse RM, Ackland GL(2012). [Perioperative fluid therapy]. Praxis (Bern 1994) vol. 101, (17) 1113-1118.

McGinley A, Pearse RM(2012). A national early warning score for acutely ill patients. BMJ (Online) vol. 345, (7869)

Young EL, Karthikesalingam A, Huddart S, Pearse RM, Hinchliffe RJ, Loftus IM, Thompson MM, Holt PJE(2012). A systematic review of the role of cardiopulmonary exercise testing in vascular surgery. European Journal of Vascular and Endovascular Surgery vol. 44, (1) 64-71.

Devereaux PJ, Chan MT, Alonso-Coello P, Walsh M, Berwanger O, Villar JC, Wang CY, Garutti RI et al.(2012). Association between postoperative troponin levels and 30-day mortality among patients undergoing noncardiac surgery (Journal of the American Medical Association (2012) 307, 21 (2295-2304)). JAMA - Journal of the American Medical Association vol. 307, (24)

Grocott MPW, Pearse RM(2012). Perioperative medicine: the future of anaesthesia?. BRITISH JOURNAL OF ANAESTHESIA vol. 108, (5) 723-726.

Pearse RM, Ackland GL(2012). Perioperative fluid therapy. BMJ vol. 344,

Bangash MN, Kong M-L, Pearse RM(2012). Use of inotropes and vasopressor agents in critically ill patients. Br J Pharmacol vol. 165, (7) 2015-2033.

Devereaux PJ, Chan MT, Alonso-Coello P, Walsh M, Berwanger O, Villar JC, Wang CY, Garutti RI et al.(2012). Association between postoperative troponin levels and 30-day mortality among patients undergoing noncardiac surgery. JAMA: Journal of the American Medical Association vol. 307, (21) 2295-2304.

Frith D, Guerreiro M, Pearse R, Thiemermann C, Brohi K (2012). EXPERIMENTAL ACUTE TRAUMATIC COAGULOPATHY IS ASSOCIATED WITH MODERATE IMPAIRMENT OF THROMBIN GENERATION AND DYSFIBRINOGENEMIA. SHOCK. vol. 37, 34-34.

Terblanche M, Kruger P, di Gangi S, Gearay S, Gilfeather L, Ferguson ND, Pearse R, Beale R et al.(2012). Risk factors for acute organ failure in intensive care unit patients who receive respiratory support in the absence of non-respiratory organ failure: an international prospective cohort study. CRITICAL CARE vol. 16, (2) Article ARTN R61,

Davenport R, Manson J, De'Ath H, Platton S, Coates A, Allard S, Hart D, Pearse R et al.(2011). Functional definition and characterization of acute traumatic coagulopathy. Crit Care Med vol. 39, (12) 2652-2658.

Pearse R, Holt P, Grocott M(2011). Authors' reply to Petros and colleagues. BMJ (Online) vol. 343, (7833)

Pearse RM, Holt PJE, Grocott MPW(2011). Managing perioperative risk in patients undergoing elective non-cardiac surgery. BMJ vol. 343,

James S, Jhanji S, Niebrzegowska E, Tarrell T, Smith AV, Pearse R (2011). PERI-OPERATIVE MICROVASCULAR FLOW AND CARDIO-PULMONARY EXERCISE TESTLNG IN HIGH RISK SURGICAL PATIENTS. INTENSIVE CARE MEDICINE. vol. 37, S132-S132.

Kavsak PA, Walsh M, Srinathan S, Thorlacius L, Buse GL, Botto F, Pettit S, McQueen MJ et al.(2011). High sensitivity troponin T concentrations in patients undergoing noncardiac surgery: A prospective cohort study. Clinical Biochemistry vol. 44, (12) 1021-1024.

Frith D, Baptista ML, Cohen M, Pearse R, Thiemermann C, Brohi K(2011). Experimental acute traumatic coagulopathy is due to systemic activation of protein c during hypoperfusion. JOURNAL OF THROMBOSIS AND HAEMOSTASIS vol. 9, 481-481.

MacDonald N, Pearse RM(2011). Peri-operative hemodynamic therapy: only large clinical trials can resolve our uncertainty. Crit Care vol. 15, (3)

Pearse RM, Rhodes A, Moreno R, Pelosi P, Spies C, Vallet B, Metnitz P, Bauer P et al.(2011). EuSOS: European surgical outcomes study. Eur J Anaesthesiol vol. 28, (6) 454-456.

Davenport R, Manson J, De'Ath H, Platton S, Coates A, Allard S, Hart D, Pearse R et al. (2011). Point of care diagnostics for the rapid identification of acute traumatic coagulopathy and prediction of massive trauma haemorrhage. BRITISH JOURNAL OF SURGERY. vol. 98, 7-7.

Pearse R, Holt P, Grocott M(2011). Authors' reply to Petros and colleagues. BMJ vol. 343,

Frith D, Baptista ML, Cohen MJ, Pearse R, Thiemermann C, Brohi K(2011). EXPERIMENTAL ACUTE TRAUMATIC COAGULOPATHY: INITIATED BY HYPOPERFUSION, MODULATED BY THE PROTEIN C PATHWAY. SHOCK vol. 36, 16-17.

Davenport R, Curry N, Manson J, De'Ath H, Coates A, Rourke C, Pearse R, Stanworth S et al.(2011). Hemostatic effects of fresh frozen plasma may be maximal at red cell ratios of 1:2. J Trauma vol. 70, (1) 90-95.

Correa T, Kindler R, Brandt S, Gorrasi J, Regueira T, Bracht H, Porta F, Takala J et al.(2011). Impact of hepatic venous oxygen efflux and carotid blood flow on the difference between mixed and central venous oxygen saturation. Critical care (London, England) vol. 15, (Suppl 1) P35-P35.

Martin-Loeches I, Lisboa T, Rhodes A, Moreno RP, Silva E, Sprung C, Chiche JD, Barahona D et al.(2011). Use of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1)v influenza A infection. Intensive Care Medicine vol. 37, (2) 272-283.

Frith D, Stanworth S, Gaarder C, Maegele M, Goslings C, Johansson P, Allard S, Cohen M et al.(2010). Acute traumatic coagulopathy is dependent upon injury load and shock. BRITISH JOURNAL OF SURGERY vol. 97, 39-40.

Martin-Loeches I, Lisboa T, Rhodes A, Moreno R, Silva E, Sprung C, Chiche J, Barahona D et al. (2010). USE OF CORTICOSTEROID THERAPY IN PATIENTS AFFECTED BY SEVERE PANDEMIC (H1N1)V INFLUENZA A INFECTION. INTENSIVE CARE MEDICINE. vol. 36, S319-S319.

Pearse RM(2010). Another inconvenient truth: Meeting the challenge of preventing poor surgical outcomes. Current Opinion in Critical Care vol. 16, (4) 337-338.

Martin GS, Pearse R(2010). Current Opinion in Critical Care: Editorial introductions. Current Opinion in Critical Care vol. 16, (4)

Rampal T, Jhanji S, Pearse RM(2010). Using oxygen delivery targets to optimize resuscitation in critically ill patients. Curr Opin Crit Care vol. 16, (3) 244-249.

Spanos A, Jhanji S, Vivian-Smith A, Harris T, Pearse RM(2010). EARLY MICROVASCULAR CHANGES IN SEPSIS AND SEVERE SEPSIS. SHOCK vol. 33, (4) 387-391.

Pearse RM(2010). Water, taken in moderation, cannot hurt anybody (Mark Twain 1835-1910). J PHYSIOL-LONDON vol. 588, (2) 281-282.

Jhanji S, Vivian-Smith A, Lucena-Amaro S, Watson D, Hinds CJ, Pearse RM(2010). Haemodynamic optimisation improves tissue microvascular flow and oxygenation after major surgery: a randomised controlled trial. Crit Care vol. 14, (4)

Grocott MPW, Pearse RM(2010). Prognostic studies of perioperative risk: Robust methodology is needed. British Journal of Anaesthesia vol. 105, (3) 243-245.

Frith D, Cohen M, Pearse R, Thiemermann C, Brohi K (2010). Rodent coagulation responses to trauma and haemorrhagic shock. INFLAMMATION RESEARCH. vol. 59, S26-S27.

Pearse R, Bennett D, Hinds C(2009). Dopexamine and survival: Areas of consistency. Anaesthesia vol. 64, (11)

Jhanji S, Vivian-Smith A, Lucena-Amaro S, Watson D, Hinds CJ, Pearse RM (2009). A RANDOMISED CONTROLLED TRIAL OF THE EFFECTS OF POST-OPERATIVE HAEMODYNAMIC OPTIMISATION ON MICROVASCULAR FLOW, TISSUE OXYGENATION AND INFLAMMATORY MARKERS AFTER MAJOR ABDOMINAL SURGERY. INTENSIVE CARE MEDICINE. vol. 35, 213-213.

Shepherd SJ, Pearse RM(2009). Role of Central and Mixed Venous Oxygen Saturation Measurement in Perioperative Care. ANESTHESIOLOGY vol. 111, (3) 649-656.

Powell-Tuck J, Gosling P, Lobo DN, Carlson GL, Allison SP, Gore M, Lewington AJ, Pearse RL et al.(2009). Intravenous fluids in surgery: Authors of guideline respond. BMJ (Online) vol. 339, (7715)

Jhanji S, Pearse RM(2009). The use of early intervention to prevent postoperative complications. Curr Opin Crit Care vol. 15, (4) 349-354.

Jhanji S, Stirling S, Patel N, Hinds CJ, Pearse RM(2009). The effect of increasing doses of norepinephrine on tissue oxygenation and microvascular flow in patients with septic shock. Crit Care Med vol. 37, (6) 1961-1966.

Jhanji S, Lee C, Watson D, Hinds C, Pearse RM(2009). Microvascular flow and tissue oxygenation after major abdominal surgery: association with post-operative complications. Intensive Care Med vol. 35, (4) 671-677.

Frith D, Chesebro B, Pittet JF, Cohen MJ, Thiemermann C, Pearse R, Brohi K (2009). ACUTE TRAUMATIC COAGULOPATHY IS DRIVEN BY SYSTEMIC HYPOPERFUSION INDEPENDENT OF HYPOTENSION AND HAEMORRHAGE VOLUME. SHOCK. vol. 32, 9-9.

Maddison B, Wolff C, Findlay G, Radermacher P, Hinds C, Pearse RM(2009). Comparison of three methods of extravascular lung water volume measurement in patients after cardiac surgery. Crit Care vol. 13, (4)

Jhanji S, Stirling S, Patel NSA, Hinds CJ, Pearse RM (2009). EFFECT OF INCREASING DOSES OF NOREPINEPHRINE ON TISSUE OXYGENATION AND MICROVASCULAR PERFUSION IN SEPTIC SHOCK. SHOCK. vol. 32, 2-2.

Pearse RM(2009). Extending the role of lactate measurement into the prehospital environment. Crit Care vol. 13, (1)

Morris CG, Pearse RM(2009). Pro-con debate: We should not measure cardiac output in critical care. Media, War and Conflict vol. 10, (1) 8-12.

Powell-Tuck J, Allison SP, Gosling P, Lobo DN, Carlson GL, Gore M, Lewington AJ, Pearse RM et al.(2009). Summary of the British Consensus Guidelines on Intravenous Fluid Therapy for Adult Surgical Patients (GIFTASUP) - For comment. Media, War and Conflict vol. 10, (1) 13-15.

Davenport R, Coates A, Allard S, Pasi J, MacCallum P, Stanworth S, Thiemermann C, Pearse R et al. (2009). TRAUMA HAEMORRHAGE: EVOLVING ROLE OF ROTEM FOR PREDICTING TRANSFUSION REQUIREMENTS. SHOCK. vol. 32, 15-15.

Maddison B, Giudici R, Calzia E, Wolff C, Hinds C, Radermacher P, Pearse RM(2008). Extravascular lung water volume measurement by a novel lithium-thermal indicator dilution method: comparison of three techniques to post-mortem gravimetry. Intensive Care Med vol. 34, (11) 2106-2111.

Jhanji S, Thomas B, Ely A, Watson D, Hinds CJ, Pearse RM(2008). Mortality and utilisation of critical care resources amongst high-risk surgical patients in a large NHS trust. Anaesthesia vol. 63, (7) 695-700.

Pearse RM, Belsey JD, Cole JN, Bennett ED(2008). Effect of dopexamine infusion on mortality following major surgery: Individual patient data meta-regression analysis of published clinical trials. CRIT CARE MED vol. 36, (4) 1323-1329.

Jhanji S, Dawson J, Pearse RM(2008). Cardiac output monitoring: basic science and clinical application. Anaesthesia vol. 63, (2) 172-181.

Maddison B, Findlay G, Radermacher P, Hinds C, Pearse RM (2008). Intrathoracic blood volume measurement: A comparison of transpulmonary lithium indicator dilution with indocyanine green indicator dilution. SHOCK. vol. 29, 63-63.

Maddison B, Wolff C, Findlay G, Calzia E, Hinds C, Pearse R(2008). Intrathoracic blood volume measurement: comparison of transpulmonary lithium indicator dilution with indocyanine green indicator dilution. Critical care (London, England) vol. 12, (Suppl 2) P103-P103.

Jhanji S, Lee C, Watson D, Hinds CJ, Pearse RM (2008). Tissue oxygenation and microvascular flow after major abdominal surgery. SHOCK. vol. 29, 64-64.

Frith D, Chesebro B, Patel N, Thiemermann C, Brohi K, Cohen M, Pearse R (2008). Towards a mouse model for acute coagulopathy of trauma/shock. SHOCK. vol. 29, 6-6.

Pearse RM, Young JD(2007). Steroids to prevent postextubation laryngeal oedema. Lancet vol. 369, (9567) 1060-1061.

Pearse RM, Dawson D, Fawcett J, Rhodes A, Grounds RM, Bennett D(2007). The incidence of myocardial injury following post-operative Goal Directed Therapy. BMC Cardiovasc Disord vol. 7,

Belsey J, Pearse R, Cole J, Bennet D(2007). An individual patient meta-analysis of clinical trials using dopexamine to increase oxygen delivery in high-risk surgical patients. Critical care (London, England) vol. 11, (Suppl 2) P315-P315.

McGinley A, Pearse RM(2007). Medical emergency teams: implementation and outcome measurement. Critical care (London, England) vol. 11, (2) 307-307.

Maddison B, Best T, Wolff C, Jones P, Hinds C, Pearse R(2007). Transpulmonary lithium indicator dilution: a new method of intrathoracic blood volume measurement. Critical care (London, England) vol. 11, (Suppl 2) P295-P295.

Collinson PO, Wort S, Bruce H, Rhodes A, Pearse R, Bennett ED (2006). Plasma DNA concentration as a predictor of mortality and sepsis in general intensive care patients. CLINICAL CHEMISTRY. vol. 52, A12-A12.

Pearse RM, Harrison DA, James P, Watson D, Hinds C, Rhodes A, Grounds RM, Bennett ED(2006). Identification and characterisation of the high-risk surgical population in the United Kingdom. Crit Care vol. 10, (3)

Pearse RM, Hinds CJ(2006). Should we use central venous saturation to guide management in high-risk surgical patients?. Crit Care vol. 10, (6)

Wort SJ, Rhodes A, Thomas H, Pearse R, Collinson P, Bennett ED (2005). The role of plasma DNA concentration as a predictor of mortality and sepsis in critically ill patients. THORAX. vol. 60, II116-II116.

Bates CJ, Pearse R(2005). Use of hydrogen peroxide vapour for environmental control during a Serratia outbreak in a neonatal intensive care unit. J Hosp Infect vol. 61, (4) 364-366.

Jin DK, Young LM, Vincent L, Gelbshtein U, Pekle K, Lam G, Shido K, Cho HJ et al. (2005). Multimodular analysis of angiogenic biomarkers in the primary treatment of multiple myeloma: Correlative studies of the BiRD trial. BLOOD. vol. 106, 972A-972A.

Pearse R, Dawson D, Fawcett J, Rhodes A, Grounds RM, Bennett ED(2005). Changes in central venous saturation after major surgery, and association with outcome. Critical care (London, England) vol. 9, (6)

Pearse R, Dawson D, Fawcett J, Rhodes A, Grounds M, Bennnett D(2005). Early goal directed therapy reduces morbidity and length of hospital stay following high-risk surgery. Critical care (London, England) vol. 9, (Suppl 1) P45-P45.

Pearse R, Dawson D, Fawcett J, Rhodes A, Grounds RM, Bennett ED(2005). Early goal-directed therapy after major surgery reduces complications and duration of hospital stay. A randomised, controlled trial [ISRCTN38797445]. Critical care (London, England) vol. 9, (6)

Pearse RM, Rhodes A, Grounds RM(2004). Clinical review: How to optimize management of high-risk surgical patients. Critical Care vol. 8, (6) 503-507.

Pearse RM(2004). Equipment review. Critical Care vol. 8, (3) 193-195.

Pearse RM, Ikram K, Barry J(2004). Equipment review: An appraisal of the LiDCO™ plus method of measuring cardiac output. Critical Care vol. 8, (3) 190-193.

Pearse R, Wort SJ(2004). Acute respiratory distress syndrome (ARDS). Clinical Intensive Care vol. 15, (1) 37-42.

Wort S, Rhodes A, Thomas H, Pearse R, Collinson P(2004). Plasma DNA concentration as a predictor of mortality and sepsis in critically ill patients. Critical care (London, England) vol. 8, (Suppl 1) P187-P187.

Pearse R, Dawson D, Fawcett J, Wort S, Rhodes A, Grounds R(2004). The relationship between central venous saturation and outcome following high-risk surgery. Critical care (London, England) vol. 8, (Suppl 1) P51-P51.

Pearse R, Wort SJ, Terblanche M, Rhodes A(2003). Critical care clinical conundrums. Clinical Intensive Care vol. 14, (3-4) 149-155.

Pearse RM, Dawson D, Rhodes A, Grounds RM, Bennett ED (2003). Low central venous saturation predicts post-operative mortality. INTENSIVE CARE MEDICINE. vol. 29, S15-S15.

Dawson D, Pearse R, Rhodes A, Bennett D (2003). Reliability of venous blood gas measurements in the recognition of the acutely ill patient. INTENSIVE CARE MEDICINE. vol. 29, S178-S178.

Pearse RM, Draper A, Grounds RM(2003). Non-invasive ventilation to avoid tracheal intubation in a patient with Guillain-Barré syndrome. British Journal of Anaesthesia vol. 91, (6) 913-916.

Pearse RM, Dana EC, Lanigan CJ, Pook JAR(2001). Organisational failures in urgent and emergency surgery: A potential peri-operative risk factor. Anaesthesia vol. 56, (7) 684-689.

Pearse R(2001). Inadequate pre-operative evaluation and preparation 1. Anaesthesia vol. 56, (4)

Pearse RM, Mitra AV, Heymann TD(1999). What the SHO really does. Journal of the Royal College of Physicians of London vol. 33, (6) 553-556.

Pearse R, Rajakulendran Y(1999). Pre-operative fasting and administration of regular medications in adult patients presenting for elective surgery. Has the new evidence changed practice?. European Journal of Anaesthesiology vol. 16, (8) 565-568.

Lee CN, Vasilakis C, Kearney D, Pearse R, Millard PH(1998). An analysis of admission, discharge and bed occupancy of stroke patients aged 65 and over in English hospitals. Health Care Management Science vol. 1, (2) 151-157.

Kelly RI, Pearse R, Bull RH, Leveque JL, de Rigal J, Mortimer PS(1995). The effects of aging on the cutaneous microvasculature. Journal of the American Academy of Dermatology vol. 33, (5 PART 1) 749-756.