Publications: Prof Rupert Pearse

Vickery NJ, Fowler AJ, Prowle J, Pearse R ( 2024 ) . Association between multimorbidity and quality of life after hip replacement surgery: analysis of routinely collected patient-reported outcomes . British Journal of Anaesthesia

Giannas E, Dias P, Janssen H, Ackland G, Pearse R, Abbott T ( 2024 ) . Clinical management of stopping or continuing perioperative angiotensin II converting enzyme inhibitors and/or angiotensin receptor blockers: a survey of clinical opinion . BJA Open vol. 12 ,

Kifle F, Iverson KR, Belay E, Teko EB, Dawit A, Deneke A, Biccard B, Kifleyohanes T et al. ( 2024 ) . Towards Establishing a National Perioperative Quality Improvement Network in LMICs: Implementation Experiences From Ethiopia . Annals of Surgery Open vol. 5 , ( 3 ) e480 - e480 .

Watson S-L, Fowler AJ, Dias P, Biccard B, Wan YI, Pearse RM, Abbott TEF ( 2024 ) . The lifetime risk of surgery in England: a nationwide observational cohort study . British Journal of Anaesthesia vol. 133 , ( 4 ) 768 - 775 .

Hewitt-Smith A, Bulamba F, Patel A, Nanimambi J, Adong LR, Emacu B, Kabaleta M, Khanyalano J et al. ( 2024 ) . Family supplemented patient monitoring after surgery (SMARTER): a pilot stepped-wedge cluster-randomised trial . British Journal of Anaesthesia vol. 133 , ( 4 ) 846 - 852 .

Hussain N, Jovaisa T, Puthucheary Z, Pearse R, Phull MK ( 2024 ) . Peripherally administered vasopressors in critically ill adult patients: A survey of UK healthcare professional practices, attitudes and experiences . Journal of the Intensive Care Society

Yeung J, Jhanji S, Braun J, Dunn J, Eggleston L, Frempong S, Hiller L, Jacques C et al. ( 2024 ) . Volatile vs Total intravenous Anaesthesia for major non-cardiac surgery: a pragmatic randomised triaL (VITAL) . Trials vol. 25 , ( 1 )

Torborg A, Meyer H, El Fiky M, Fawzy M, Elhadi M, Ademuyiwa AO, Osinaike BB, Hewitt-Smith A et al. ( 2024 ) . Outcomes after surgery for children in Africa (ASOS-Paeds): a 14-day prospective observational cohort study . The Lancet vol. 403 , ( 10435 ) 1482 - 1492 .

Hughes G, Stephens TJ, Seuren LM, Pearse RM, Shaw SE ( 2024 ) . Clinical context and communication in shared decision-making about major surgery: Findings from a qualitative study with colorectal, orthopaedic and cardiac patients . Health An Interdisciplinary Journal for the Social Study of Health Illness and Medicine

Harji DP, Griffiths B, Stocken D, Pearse R, Blazeby J, Brown JM ( 2024 ) . Protocolized care pathways in emergency general surgery: a systematic review and meta-analysis . British Journal of Surgery vol. 111 , ( 3 )

Kachapila M, Monahan M, Ademuyiwa AO, Adinoyi YM, Biccard BM, George C, Ghosh DN, Glasbey J et al. ( 2024 ) . Erratum to ‘Exploring the cost-effectiveness of high versus low perioperative fraction of inspired oxygen in the prevention of surgical site infections among abdominal surgery patients in three low- and middle-income countries’ [BJA Open 7 (2023) 100207] . BJA Open vol. 10 ,

Janssen H, Jhanji S, Oliver NS, Ackland GL, Investigators FTG, Korbonits M, Henson S, Yeung J et al. ( 2024 ) . Ward monitoring 4.0: real-time metabolic insights from continuous glucose monitoring into perioperative organ dysfunction . British Journal of Anaesthesia vol. 132 , ( 5 ) 843 - 848 .

Davies TW, Watson N, Pilkington JJ, McClelland TJ, Azzopardi G, Pearse RM, Prowle J, Puthucheary Z ( 2024 ) . Creatine supplementation for optimization of physical function in the patient at risk of functional disability: A systematic review and meta‐analysis . Journal of Parenteral and Enteral Nutrition vol. 48 , ( 4 ) 389 - 405 .

Kachapila M, Monahan M, Ademuyiwa AO, Adinoyi YM, Biccard BM, George C, Ghosh DN, Glasbey J et al. ( 2024 ) . Erratum to “Exploring the cost-effectiveness of high versus low perioperative fraction of inspired oxygen in the prevention of surgical site infections among abdominal surgery patients in three low- and middle-income countries” [BJA Open 7 (2023) 100207] . BJA Open vol. 9 ,

del Arroyo AG, Patel A, Abbott TEF, Begum S, Dias P, Somanath S, Middleditch A, Cleland S et al. ( 2024 ) . Preoperative N-terminal pro-B-type natriuretic peptide and myocardial injury after stopping or continuing renin–angiotensin system inhibitors in noncardiac surgery: a prespecified analysis of a phase 2 randomised controlled multicentre trial . British Journal of Anaesthesia vol. 132 , ( 5 ) 857 - 866 .

Prowle JR, Croal B, Abbott TEF, Cuthbertson BH, Wijeysundera DN, Myles PS, Shulman MA, Wallace S et al. ( 2024 ) . Cystatin C or creatinine for pre-operative assessment of kidney function and risk of post-operative acute kidney injury: a secondary analysis of the METS cohort study . Clinical Kidney Journal vol. 17 , ( 1 )

Gerber C, Bishop DG, Dyer RA, Maswime S, Rodseth RN, van Dyk D, Kluyts H-L, Mbwele B et al. ( 2024 ) . Method of Anesthesia and Perioperative Risk Factors, Maternal Anesthesia Complications, and Neonatal Mortality Following Cesarean Delivery in Africa: A Substudy of a 7-Day Prospective Observational Cohort Study . Anesthesia & Analgesia vol. 138 , ( 6 ) 1275 - 1284 .

Booth J, Fowler AJ, Pearse R, Dias P, Wan YI, Witton R, Abbott TEF ( 2024 ) . Dental Surgical Activity in Hospitals during COVID-19: A Nationwide Observational Cohort Study . JDR Clinical & Translational Research vol. 9 , ( 4 ) 387 - 397 .

Page A, Langan A, Wan YI, McNelly A, Prowle J, Pearse R, Puthucheary Z ( 2023 ) . Association between energy surplus and intensive care unit length of stay in critically ill patients: A retrospective cohort study . Journal of Parenteral and Enteral Nutrition vol. 48 , ( 2 ) 206 - 214 .

McNelly A, Langan A, Bear DE, Page A, Martin T, Seidu F, Santos F, Rooney K et al. ( 2023 ) . A pilot study of alternative substrates in the critically Ill subject using a ketogenic feed . Nature Communications vol. 14 , ( 1 )

Hughes G, Shaw SE, Pearse RM, Stephens TJ ( 2023 ) . Opportunities for shared decision-making about major surgery with high-risk patients: the switch from ‘fixing the problem’ to undertaking shared decision-making. Response to Br J Anaesth 2023; 131: e152–3 . British Journal of Anaesthesia vol. 132 , ( 2 )

Ludwiczak A, Stephens TJ, Prowle J, Pearse R, Osman M ( 2023 ) . Supporting effective shared decision‐making in surgical context: Why framing of choices matters for high‐risk patients and clinicians . Colorectal Disease vol. 26 , ( 1 ) 110 - 119 .

Davies TW, Kelly E, van Gassel RJJ, van de Poll MCG, Gunst J, Casaer MP, Christopher KB, Preiser JC et al. ( 2023 ) . A systematic review and meta-analysis of the clinimetric properties of the core outcome measurement instruments for clinical effectiveness trials of nutritional and metabolic interventions in critical illness (CONCISE) . Critical Care vol. 27 , ( 1 )

van Lier F, Hoeks S, Pearse RM ( 2023 ) . Prediction, prognosis, and professionalism in perioperative medicine . British Journal of Anaesthesia vol. 132 , ( 1 ) 13 - 14 .

Ackland G ( 2023 ) . Discontinuation vs. continuation of renin–angiotensin system inhibition before non-cardiac surgery: the SPACE trial . European Heart Journal Article ehad716 ,

Wan YI, Smuk M, Pearse RM, Paparini S, Apea VJ, Orkin CM ( 2023 ) . Clinical research in the NHS: a cross-sectional study of research engagement during the monkeypox pandemic . BMJ Leader vol. 7 , ( Suppl 2 )

Roshanov PS, Chan MTV, Borges FK, Conen D, Wang CY, Xavier D, Berwanger O, Marcucci M et al. ( 2023 ) . One-year Outcomes after Discharge from Noncardiac Surgery and Association between Predischarge Complications and Death after Discharge: Analysis of the VISION Prospective Cohort Study . Anesthesiology vol. 140 , ( 1 ) 8 - 24 .

Harji D, Griffiths B, Stocken D, Pearse R, Blazeby J, Brown J ( 2023 ) . SP9.9 Protocolised Care Pathways in Emergency General Surgery: A systematic review and meta-analysis . British Journal of Surgery vol. 110 , ( Supplement_6 )

Torrance HD, Zhang P, Longbottom ER, Mi Y, Whalley JP, Allcock A, Kwok AJ, Cano-Gamez E et al. ( 2023 ) . A Transcriptomic Approach to Understand Patient Susceptibility to Pneumonia After Abdominal Surgery . Annals of Surgery vol. 279 , ( 3 ) 510 - 520 .

Andrew BY, Brookhart MA, Pearse R, Raghunathan K, Krishnamoorthy V ( 2023 ) . Propensity score methods in observational research: brief review and guide for authors . British Journal of Anaesthesia vol. 131 , ( 5 ) 805 - 809 .

Kachapila M, Monahan M, Ademuyiwa AO, Adinoyi YM, Biccard BM, George C, Ghosh DN, Glasbey J et al. ( 2023 ) . Exploring the cost-effectiveness of high versus low perioperative fraction of inspired oxygen in the prevention of surgical site infections among abdominal surgery patients in three low- and middle-income countries . BJA Open vol. 7 ,

Fowler AJ, Wahedally MAH, Abbott TEF, Prowle JR, Cromwell DA, Pearse RM ( 2023 ) . Long-term disease interactions amongst surgical patients: a population cohort study . British Journal of Anaesthesia vol. 131 , ( 2 ) 407 - 417 .

Fowler AJ, Brayne AB, Pearse RM, Prowle JR ( 2023 ) . Long-term healthcare use after postoperative complications: an analysis of linked primary and secondary care routine data . BJA Open vol. 7 ,

Haines RW, Fowler AJ, Liang K, Pearse RM, Larsson AO, Puthucheary Z, Prowle JR ( 2023 ) . Comparison of Cystatin C and Creatinine in the Assessment of Measured Kidney Function during Critical Illness . Clin J Am Soc Nephrol

Edwards MR, Forbes G, Walker N, Morton DG, Mythen MG, Murray D, Anderson I, Mihaylova B et al. ( 2023 ) . Fluid Optimisation in Emergency Laparotomy (FLO-ELA) Trial: study protocol for a multi-centre randomised trial of cardiac output-guided fluid therapy compared to usual care in patients undergoing major emergency gastrointestinal surgery . Trials vol. 24 , ( 1 )

Shaw SE, Hughes G, Pearse R, Avagliano E, Day JR, Edsell ME, Edwards JA, Everest L et al. ( 2023 ) . Opportunities for shared decision-making about major surgery with high-risk patients: a multi-method qualitative study . British Journal of Anaesthesia vol. 131 , ( 1 ) 56 - 66 .

Wan YI, Puthucheary ZA, Pearse RM, Prowle JR ( 2023 ) . Characterising biological mechanisms underlying ethnicity-associated outcomes in COVID-19 through biomarker trajectories: a multicentre registry analysis . British Journal of Anaesthesia vol. 131 , ( 3 ) 491 - 502 .

Abani O, Abbas A, Abbas F, Abbas J, Abbas K, Abbas M, Abbasi S, Abbass H et al. ( 2023 ) . Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial . The Lancet vol. 401 , ( 10387 ) 1499 - 1507 .

Duceppe E, Borges FK, Conen D, Tiboni M, Chan MTV, Patel A, Sessler DI, Kavsak PA et al. ( 2023 ) . Association of Preoperative Growth Differentiation Factor-15 Concentrations and Postoperative Cardiovascular Events after Major Noncardiac Surgery . Anesthesiology vol. 138 , ( 5 ) 508 - 522 .

Glasbey J, Glasbey J, Ademuyiwa A, Bhatt A, Biccard B, Blazeby J, Brocklehurst P, Chakrabortee S et al. ( 2023 ) . Adaptation of the Wound Healing Questionnaire universal-reporter outcome measure for use in global surgery trials (TALON-1 study): mixed-methods study and Rasch analysis . British Journal of Surgery vol. 110 , ( 6 ) 685 - 700 .

McClelland TJ, Fowler AJ, Davies TW, Pearse R, Prowle J, Puthucheary Z ( 2023 ) . Can pioglitazone be used for optimization of nutrition in critical illness? A systematic review . Journal of Parenteral and Enteral Nutrition vol. 47 , ( 4 ) 459 - 475 .

Borges FK, Duceppe E, Heels-Ansdell D, Patel A, Sessler DI, Tandon V, Chan M, Pearse R et al. ( 2023 ) . High-sensitivity Troponin I Predicts Major Cardiovascular Events after Non-Cardiac Surgery: A Vascular Events in Non-Cardiac Surgery Patients Cohort Evaluation (VISION) Substudy . Clinical Chemistry vol. 69 , ( 5 ) 492 - 499 .

Fowler AJ, Brayne A, Pearse RM, Prowle JR ( 2023 ) . Long-term healthcare use after postoperative complications: a prospective analysis of linked primary and secondary care routine data .

Jackson AIR, Boney O, Pearse RM, Kurz A, Cooper DJ, van Klei WA, Cabrini L, Miller TE et al. ( 2023 ) . Systematic reviews and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative: mortality, morbidity, and organ failure . British Journal of Anaesthesia vol. 130 , ( 4 ) 404 - 411 .

Duceppe E, Borges FK, Tiboni M, Pearse R, Chan MTV, Srinathan S, Kavsak PA, Garg AX et al. ( 2023 ) . High-Sensitivity Cardiac Troponin I Thresholds to Identify Myocardial Injury After Noncardiac Surgery: A Cohort Study . Canadian Journal of Cardiology vol. 39 , ( 3 ) 311 - 318 .

Toal CM, Fowler AJ, Pearse RM, Puthucheary Z, Prowle JR, Wan YI ( 2022 ) . Health Resource Utilisation and Disparities: an Ecological Study of Admission Patterns Across Ethnicity in England Between 2017 and 2020 . Journal of Racial and Ethnic Health Disparities vol. 10 , ( 6 ) 2872 - 2881 .

Kluyts H, Bedwell GJ, Bedada AG, Fadalla T, Hewitt‐Smith A, Mbwele BA, Mrara B, Omigbodun A et al. ( 2022 ) . Determining the Minimum Dataset for Surgical Patients in Africa: A Delphi Study . World Journal of Surgery vol. 47 , ( 3 ) 581 - 592 .

Glasbey J, ABBOTT T, Fowler A, Pearse R ( 2022 ) . Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries . The Lancet

Paterson A, Maswime S, Hardy A, Pearse RM, Biccard BM, group ICWTASOGAISO ( 2022 ) . Postoperative outcomes associated with surgical care for women in Africa: an international risk-adjusted analysis of prospective observational cohorts . BJA Open vol. 4 ,

Fowler AJ, Trivedi B, Boomla K, Pearse R, Prowle J ( 2022 ) . Change in healthcare utilisation after surgical treatment: observational study of routinely collected patient data from primary and secondary care . British Journal of Anaesthesia vol. 129 , ( 6 ) 889 - 897 .

Stephens TJ, Pearse RM ( 2022 ) . The limitations of shared decision-making in surgery . British Journal of Surgery vol. 109 , ( 11 ) 1051 - 1052 .

Bedwell GJ, Dias P, Hahnle L, Anaeli A, Baker T, Beane A, Biccard BM, Bulamba F et al. ( 2022 ) . Barriers to Quality Perioperative Care Delivery in Low- and Middle-Income Countries: A Qualitative Rapid Appraisal Study . Anesthesia & Analgesia vol. 135 , ( 6 ) 1217 - 1232 .

Hajjar LA, Quintão VC, Vieira APZ, Nakada LN, Pearse RM, Ramirez MBD, la Medina AR, Alvarez A et al. ( 2022 ) . Latin American surgical outcomes study: study protocol for a multicentre international observational cohort study of patient outcomes after surgery in Latin American countries . BJA Open vol. 3 ,

Fowler A, Wan Y, Prowle J, Pearse R, ABBOTT T ( 2022 ) . Long-term mortality following complications after elective surgery: a secondary analysis of pooled data from two prospective cohort studies . British Journal of Anaesthesia

Davies TW, van Gassel RJJ, van de Poll M, Gunst J, Casaer MP, Christopher KB, Preiser JC, Hill A et al. ( 2022 ) . Core outcome measures for clinical effectiveness trials of nutritional and metabolic interventions in critical illness: an international modified Delphi consensus study evaluation (CONCISE) . Critical Care vol. 26 , ( 1 )

Abani O, Abbas A, Abbas F, Abbas J, Abbas K, Abbas M, Abbasi S, Abbass H et al. ( 2022 ) . Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis . The Lancet vol. 400 , ( 10349 ) 359 - 368 .

Collaborative SCAT, Kouli O, Murray V, Bhatia S, Cambridge W, Kawka M, Shafi S, Knight et al. ( 2022 ) . Evaluation of prognostic risk models for postoperative pulmonary complications in adult patients undergoing major abdominal surgery: a systematic review and international external validation cohort study . The Lancet Digital Health vol. 4 , ( 7 ) e520 - e531 .

Glasbey J, Trout I, Adeyeye V, Ademuyiwa A, Adisa A, Bhatt A, Biccard B, Brocklehurst P et al. ( 2022 ) . Use of Telemedicine for Postdischarge Assessment of the Surgical Wound . Annals of Surgery vol. 277 , ( 6 ) e1331 - e1347 .

Patel J, Tolppa T, Biccard BM, Fazzini B, Haniffa R, Marletta D, Moonesinghe R, Pearse R et al. ( 2022 ) . Perioperative Care Pathways in Low‐ and Lower‐Middle‐Income Countries: Systematic Review and Narrative Synthesis . World Journal of Surgery vol. 46 , ( 9 ) 2102 - 2113 .

Calvache JA, Delgado M, Stefani LC, Biccard B, Pearse RM ( 2022 ) . The need for a joint response. Perioperative mortality in Latin America and the time for LASOS Study . Colombian Journal of Anesthesiology vol. 50 , ( 3 )

Fowler AJ, Dias P, Hui S, Cashmore R, Laloo R, Ahmad AN, Gillies MA, Wan YI et al. ( 2022 ) . Liberal or restrictive antimicrobial prophylaxis for surgical site infection: systematic review and meta-analysis of randomised trials . British Journal of Anaesthesia vol. 129 , ( 1 ) 104 - 113 .

Fazzini B, Fowler AJ, Pearse R, Puthucheary Z ( 2022 ) . Adjusting meta-analysis data to reduce heterogeneity: the need for objective evaluation of observational studies. Response to Br J Anaesth 2022; 128: e303-5 . British Journal of Anaesthesia vol. 129 , ( 1 ) e10 - e12 .

Ripollés-Melchor J, Abad-Motos A, Cecconi M, Pearse R, Jaber S, Slim K, Francis N, Spinelli A et al. ( 2022 ) . Association between use of enhanced recovery after surgery protocols and postoperative complications in colorectal surgery in Europe: The EuroPOWER international observational study . Journal of Clinical Anesthesia vol. 80 ,

Stefani LC, Hajjar L, Biccard B, Pearse RM ( 2022 ) . The need for data describing the surgical population in Latin America . British Journal of Anaesthesia vol. 129 , ( 1 ) 10 - 12 .

Wan YI, Apea VJ, Dhairyawan R, Puthucheary ZA, Pearse RM, Orkin CM, Prowle JR ( 2022 ) . Ethnic disparities in hospitalisation and hospital-outcomes during the second wave of COVID-19 infection in east London . Scientific Reports vol. 12 , ( 1 )

Haines RW, Fowler AJ, Wan YI, Flower L, Heyland DK, Day A, Pearse RM, Prowle JR et al. ( 2022 ) . Catabolism in Critical Illness: A Reanalysis of the REducing Deaths due to OXidative Stress (REDOXS) Trial . Crit Care Med

Stahlschmidt A, Passos SC, Cardoso GR, Schuh GJ, Gutierrez CS, Castro SMJ, Caumo W, Pearse RM et al. ( 2022 ) . Enhanced peri‐operative care to improve outcomes for high‐risk surgical patients in Brazil: a single‐centre before‐and‐after cohort study . Anaesthesia vol. 77 , ( 4 ) 416 - 427 .

Bien Z, Fowler AJ, Robbins AJ, Pearse RM, Prowle JR, Wan YI ( 2022 ) . Trends in Hospital Admissions Associated with an Acute Kidney Injury in England 1998–2020: a Repeated Cross-Sectional Study . SN Comprehensive Clinical Medicine vol. 4 , ( 1 ) 53 - 53 .

Savic LC, Savic S, Pearse RM ( 2022 ) . Mandatory vaccination of National Health Service staff against COVID-19: more harm than good? . British Journal of Anaesthesia vol. 128 , ( 4 ) 608 - 609 .

Abani O, Abbas A, Abbas F, Abbas M, Abbasi S, Abbass H, Abbott A, Abdallah N et al. ( 2022 ) . Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial . The Lancet vol. 399 , ( 10325 ) 665 - 676 .

Abbott T, Pearse R ( 2022 ) . Postoperative CPAP after major abdominal surgery – Authors' reply . The Lancet Respiratory Medicine vol. 10 , ( 2 ) e12 - e13 .

van der Merwe F, Vickery NJ, Kluyts H-L, Yang D, Han Y, Munlemvo DM, Ashebir DZ, Mbwele B et al. ( 2021 ) . Postoperative Outcomes Associated With Procedural Sedation Conducted by Physician and Nonphysician Anesthesia Providers: Findings From the Prospective, Observational African Surgical Outcomes Study . Anesthesia & Analgesia vol. 135 , ( 2 ) 250 - 263 .

Fowler A, Wahedally M, ABBOTT T, Smuk M, Prowle J, Pearse R, Cromwell D ( 2021 ) . Death following surgery among patients with long-term disease: Prospective study of routinely collected data in the English NHS . British Journal of Anaesthesia

Hui S, Fowler AJ, Cashmore RMJ, Fisher TJ, Schlautmann J, Body S, Lan-Pak-Kee V, Webb M et al. ( 2021 ) . Routine postoperative noninvasive respiratory support and pneumonia after elective surgery: a systematic review and meta-analysis of randomised trials . British Journal of Anaesthesia vol. 128 , ( 2 ) 363 - 374 .

Chew MS, Puelacher C, Patel A, Hammarskjöld F, Lyckner S, Kollind M, Jawad M, Andersson U et al. ( 2021 ) . Identification of myocardial injury using perioperative troponin surveillance in major noncardiac surgery and net benefit over the Revised Cardiac Risk Index . British Journal of Anaesthesia vol. 128 , ( 1 ) 26 - 36 .

Abani O, Abbas A, Abbas F, Abbas M, Abbasi S, Abbass H, Abbott A, Abdallah N et al. ( 2021 ) . Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial . The Lancet vol. 399 , ( 10320 ) 143 - 151 .

McLean KA, Kamarajah SK, Chaudhry D, Gujjuri RR, Raubenheimer K, Trout I, Al Ameer E, Creagh-Brown B et al. ( 2021 ) . Death following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic . British Journal of Surgery vol. 108 , ( 12 ) 1448 - 1464 .

Alphonsus CS, Kluyts H-L, Gobin V, Elkhogia A, Madzimbamuto FD, Tumukunde J, Omigbodun AO, Youssouf C et al. ( 2021 ) . Towards the quantification of perioperative cardiovascular risk in the African context: A sub-analysis of the South African Surgical Outcomes Study and the African Surgical Outcomes Study . South African Medical Journal vol. 111 , ( 11 ) 1065 - 1069 .

Dias P, Patel A, Rook W, Edwards MR, Pearse RM, Abbott TEF, SAPPHIRE Investigators ( 2021 ) . Contemporary use of antimicrobial prophylaxis for surgical patients: An observational cohort study . Eur J Anaesthesiol

Boney O, Moonesinghe SR, Myles PS, Grocott MPW, group TS-C, Bartoszko J, Beattie WS, Bellomo R et al. ( 2021 ) . Core Outcome Measures for Perioperative and Anaesthetic Care (COMPAC): a modified Delphi process to develop a core outcome set for trials in perioperative care and anaesthesia . British Journal of Anaesthesia vol. 128 , ( 1 ) 174 - 185 .

Fazzini B, Page A, Pearse R, Puthucheary Z ( 2021 ) . Prone positioning for non-intubated spontaneously breathing patients with acute hypoxaemic respiratory failure: a systematic review and meta-analysis . British Journal of Anaesthesia vol. 128 , ( 2 ) 352 - 362 .

Vickery N, Stephens T, du Toit L, van Straaten D, Pearse R, Torborg A, Rolt L, Puchert M et al. ( 2021 ) . Understanding the performance of a pan-African intervention to reduce postoperative mortality: a mixed-methods process evaluation of the ASOS-2 trial . British Journal of Anaesthesia vol. 127 , ( 5 ) 778 - 788 .

Pearse R ( 2021 ) . Enhanced postoperative surveillance versus standard of care to reduce mortality among adult surgical patients in Africa (ASOS-2): a cluster-randomised controlled trial . The Lancet Global Health

Wan YI, Robbins AJ, Apea VJ, Orkin CM, Pearse R, Puthucheary ZA, Prowle JR ( 2021 ) . Ethnicity and acute hospital admissions: Multi-center analysis of routine hospital data . EClinicalMedicine101077 - 101077 .

Kachapila M, Ademuyiwa AO, Biccard BM, Ghosh DN, Glasbey J, Monahan M, Moore R, Morton DG et al. ( 2021 ) . Preliminary model assessing the cost-effectiveness of preoperative chlorhexidine mouthwash at reducing postoperative pneumonia among abdominal surgery patients in South Africa . PLOS ONE vol. 16 , ( 8 )

( 2021 ) . Feasibility and diagnostic accuracy of Telephone Administration of an adapted wound heaLing QuestiONnaire for assessment for surgical site infection following abdominal surgery in low and middle-income countries (TALON): protocol for a study within a trial (SWAT) . Trials vol. 22 , ( 1 )

Ladha KS, Cuthbertson BH, Abbott TEF, Pearse RM, Wijeysundera DN ( 2021 ) . Functional decline after major elective non‐cardiac surgery: a multicentre prospective cohort study . Anaesthesia vol. 76 , ( 12 ) 1593 - 1599 .

Wan YI, Apea VJ, Dhairyawan R, Puthucheary ZA, Pearse RM, Orkin CM, Prowle JR ( 2021 ) . Ethnic disparities in hospitalisation and hospital-outcomes during the second wave of COVID-19 infection in east London . medrxiv

Abeles RD, Pearse R, Powell-Tuck J ( 2021 ) . Initiation of nutrition in the intensive care unit and the reasons for its delay: a prospective audit . Proceedings of The Nutrition Society vol. 67 , ( OCE3 )

Pearse R, ABBOTT T, Patel A, Dias P, Hewson R, Stephens T ( 2021 ) . Postoperative continuous positive airways pressure (CPAP) to prevent pneumonia, re-intubation and death after major abdominal surgery: An international randomised trial . The Lancet Respiratory Medicine

Dobbs TD, Gibson JAG, Fowler AJ, Abbott TE, Shahid T, Torabi F, Griffiths R, Lyons RA et al. ( 2021 ) . Surgical activity in England and Wales during the COVID-19 pandemic: a nationwide observational cohort study . British Journal of Anaesthesia vol. 127 , ( 2 ) 196 - 204 .

ABBOTT T, Fowler A, Dobbs T, Gibson J, Shahid T, Dias P, Akbari A, Whitaker I et al. ( 2021 ) . Mortality after surgery with SARS-CoV-2 infection in England: A population-wide epidemiological study . BJA: British Journal of Anaesthesia

Abani O, Abbas A, Abbas F, Abbas M, Abbasi S, Abbass H, Abbott A, Abdallah N et al. ( 2021 ) . Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial . The Lancet vol. 397 , ( 10289 ) 2049 - 2059 .

Prowle JR, Forni LG, Bell M, Chew MS, Edwards M, Grams ME, Grocott MPW, Liu KD et al. ( 2021 ) . Postoperative acute kidney injury in adult non-cardiac surgery: joint consensus report of the Acute Disease Quality Initiative and PeriOperative Quality Initiative . Nature Reviews Nephrology

Zenner D ( 2021 ) . The Barts Health NHS Trust COVID-19 cohort: characteristics, outcomes and risk scoring of patients in East London . International Journal of Tuberculosis and Lung Disease

Abani O, Abbas A, Abbas F, Abbas M, Abbasi S, Abbass H, Abbott A, Abdallah N et al. ( 2021 ) . Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial . The Lancet vol. 397 , ( 10285 ) 1637 - 1645 .

Pearse RM, Ackland GL, Asai T, Hemmings HC ( 2021 ) . Preprints in perioperative medicine: immediacy for the greater good . British Journal of Anaesthesia vol. 126 , ( 5 ) 915 - 918 .

Wan YI, Bien Z, Apea VJ, Orkin CM, Dhairyawan R, Kirwan CJ, Pearse RM, Puthucheary ZA et al. ( 2021 ) . Acute Kidney Injury in COVID-19: multicentre prospective analysis of registry data . Clinical Kidney Journalsfab071- - sfab071- .

Robbins AJ, Fowler AJ, Haines RW, Pearse RM, Prowle JR, Puthucheary Z ( 2021 ) . Emergency hospital admissions associated with non-communicable diseases 1998-2018 in England, Wales and Scotland: an ecological study . Clinical Medicine vol. 21 , ( 2 ) e179 - e185 .

Mazzinari G, Serpa Neto A, Hemmes SNT, Hedenstierna G, Jaber S, Hiesmayr M, Hollmann MW, Mills GH et al. ( 2021 ) . The Association of Intraoperative driving pressure with postoperative pulmonary complications in open versus closed abdominal surgery patients – a posthoc propensity score–weighted cohort analysis of the LAS VEGAS study . BMC Anesthesiology vol. 21 , ( 1 )

Dobbs TD, Gibson JAG, Fowler AJ, Abbott TE, Shahid T, Torabi F, Griffiths R, Lyons RA et al. ( 2021 ) . Surgical activity in England and Wales during the COVID-19 pandemic: a nationwide observational cohort study . MedRxiv

Abbott TEF, Fowler AJ, Dobbs TD, Gibson J, Shahid T, Dias P, Akbari A, Whitaker IS et al. ( 2021 ) . Mortality after surgery with SARS-CoV-2 infection in England: A population-wide epidemiological study . MedRxiv

Scheeren TWL, Bakker J, Kaufmann T, Annane D, Asfar P, Boerma EC, Cecconi M, Chew MS et al. ( 2021 ) . Current use of inotropes in circulatory shock . Annals of Intensive Care vol. 11 , ( 1 )

Wan YI, Patel A, Achary C, Hewson R, Phull M, Pearse RM, Group TISOS ( 2021 ) . Postoperative infection and mortality following elective surgery in the International Surgical Outcomes Study (ISOS) . British Journal of Surgery vol. 108 , ( 2 ) 220 - 227 .

Apea VJ, Wan YI, Dhairyawan R, Puthucheary ZA, Pearse RM, Orkin CM, Prowle JR ( 2021 ) . Ethnicity and outcomes in patients hospitalised with COVID-19 infection in East London: an observational cohort study . BMJ Open vol. 11 , ( 1 ) e042140 - e042140 .

Abbott TEF, Howell S, Pearse RM, Ackland GL ( 2021 ) . Mode of blood pressure monitoring and morbidity after noncardiac surgery: A prospective multicentre observational cohort study . European Journal of Anaesthesiology vol. 38 , ( 5 ) 468 - 476 .

Bulte CSE, Boer C, Hemmes SNT, Neto AS, Binnekade JM, Hedenstierna G, Jaber S, Hiesmayr M et al. ( 2021 ) . The effects of preoperative moderate to severe anaemia on length of hospital stay . European Journal of Anaesthesiology vol. 38 , ( 6 ) 571 - 581 .

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Mcnelly AS, Flower L, Stevens TJ, Fowler AJ, Pearse RM, Prowle J, Puthucheary ZA ( 2020 ) . Attitudes of multimorbid patients to surviving future acute illness and subsequent functional disability: A systematic review . medRxiv2020.06.03.20121293 - 2020.06.03.20121293 .

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Bangash MN, Abbott TEF, Patel NSA, Hinds C, Thiemermann C, Pearse R ( 2020 ) . The Effect of β2-Adrenoceptor Agonists on Leucocyte-Endothelial Adhesion in a Rodent Model of Laparotomy and Endotoxemia . Frontiers in Immunology vol. 11 ,

Wan Y, Apea V, Dhairyawan R, Orkin C, Pearse RM, Prowle JR ( 2020 ) . ETHICAL: Ethnic Disparities In COVID-19 Admissions in east London .

Shaw S, Hughes G, Stephens T, Pearse R, Prowle J, Ashcroft RE, Avagliano E, Day J et al. ( 2020 ) . Understanding decision making about major surgery: protocol for a qualitative study of shared decision making by high-risk patients and their clinical teams . BMJ open vol. 10 , ( 5 ) e033703 - e033703 .

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Ackland GL, ABBOTT T, Jones TF, Leuwer M, Pearse R, Niebrzegowska E, Wragg A, Archbold A et al. ( 2020 ) . Early elevation in plasma high-sensitivity troponin T and morbidity after elective noncardiac surgery: prospective multicentre observational cohort study . British Journal of Anaesthesia

Thomas S, Borges F, Bhandari M, De Beer J, Urrútia Cuchí G, Adili A, Winemaker M, Avram V et al. ( 2020 ) . Association Between Myocardial Injury and Cardiovascular Outcomes of Orthopaedic Surgery: A Vascular Events in Noncardiac Surgery Patients Cohort Evaluation (VISION) Substudy . Journal of Bone and Joint Surgery vol. 102 , ( 10 ) 880 - 888 .

Duceppe E, Borges FK, Tiboni M, Pearse R, Chan MTV, Srinathan S, Kavsak P, Szalay D et al. ( 2020 ) . ASSOCIATION BETWEEN HIGH-SENSITIVITY TROPONIN I AND MAJOR CARDIOVASCULAR EVENTS AFTER NON-CARDIAC SURGERY . Journal of the American College of Cardiology vol. 75 , ( 11 )

Duceppe E, Patel A, Chan MTV, Berwanger O, Ackland G, Kavsak PA, Rodseth R, Biccard B et al. ( 2020 ) . Preoperative n-terminal pro-b-type natriuretic peptide and cardiovascular events after noncardiac surgery: A cohort study . Annals of Internal Medicine vol. 172 , ( 2 ) 96 - 104 .

Delisle M, Pradarelli JC, Panda N, Koritsanszky L, Sonnay Y, Lipsitz S, Pearse R, Harrison EM et al. ( 2020 ) . Variation in global uptake of the Surgical Safety Checklist . British Journal of Surgery vol. 107 , ( 2 ) e151 - e160 .

Fowler A, Prowle J, Pearse R, Cromwell D ( 2020 ) . Chronic disease within the NHS surgical population: An epidemiological study statistical analysis plan .

Turan A, Artis AS, Hanline C, Saha P, Maheshwari K, Kurz A, Devereaux PJ, Duceppe E et al. ( 2020 ) . Preoperative Vitamin D Concentration and Cardiac, Renal, and Infectious Morbidity after Noncardiac Surgery . Anesthesiology vol. 132 , ( 1 ) 121 - 130 .

Wan Y, McGuckin D, Fowler A, Prowle J, Pearse R, Moonesinghe R ( 2020 ) . Socioeconomic deprivation and surgical outcomes: ISOS and VISION-UK sub-study (Statistical Analysis Plan) .

Wijeysundera D, Beattie WS, Hillis G, ABBOTT T, Shulman M, Ackland G, Mazer D, Myles P et al. ( 2019 ) . Integration of the Duke Activity Status Index into Preoperative Risk Evaluation: A Multicentre Prospective Cohort Study . British Journal of Anaesthesia

Ackland GL, Abbott TEF, Minto G, Clark M, Owen T, Prabhu P, May SM, Reynolds JA et al. ( 2019 ) . Correction: Heart rate recovery and morbidity after noncardiac surgery: Planned secondary analysis of two prospective, multi-centre, blinded observational studies . PLOS ONE vol. 14 , ( 12 )

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Macdonald N, Pearse RM, Murray PT, Inzitari R, Doran P, Prowle JR ( 2019 ) . The role of goal-directed therapy in the prevention of acute kidney injury after major gastrointestinal surgery: Substudy of the OPTIMISE trial . European Journal of Anaesthesiology vol. 36 , ( 12 ) 924 - 932 .

Yang F, Walker S, Richardson G, Stephens T, Phull M, Thompson A, Pearse RM, Enhanced Peri-Operative Care for High-risk patients (EPOCH) trial group ( 2019 ) . Cost-effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery: Learning from 15,856 patients . International Journal of Surgery vol. 72 , 25 - 31 .

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Stephens TJ, Peden CJ, Haines R, Grocott MPW, Murray D, Cromwell D, Johnston C, Hare S et al. ( 2019 ) . Hospital-level evaluation of the effect of a national quality improvement programme: time-series analysis of registry data . BMJ Quality and Safety

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Fowler AJ, ABBOTT T, PROWLE J, PEARSE R ( 2019 ) . Age of patients undergoing surgery . British Journal of Surgery

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ABBOTT TEF, PEARSE RM, beattie S, Phull M, Beilstein C, Raj A, Grocott M, Cuthbertson B et al. ( 2019 ) . Chronotropic incompetence and myocardial injury after non-cardiac surgery: planned secondary analysis of a prospective observational international cohort study . BJA: British Journal of Anaesthesia vol. 123 , ( 1 ) 17 - 26 .

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Manou-Stathopoulou V, Abbott TEF, May SM, Cuthbertson BH, Wijeysundera DN, Pearse RM, Ackland GL ( 2019 ) . Perioperative plasma cortisol levels and myocardial injury after non-cardiac surgery . British Journal of Anaesthesia . vol. 122 , e45 - e46 .

May SM, Abbott TEF, Del Arroyo AG, Cuthbertson BH, Wijeysundera DN, Pearse RM, Ackland GL ( 2019 ) . Serum microRNAs and perioperative myocardial injury . British Journal of Anaesthesia . vol. 122 ,

Kocman D, Stöckelová T, Pearse R, Martin G ( 2019 ) . Neither magic bullet nor a mere tool: negotiating multiple logics of the checklist in healthcare quality improvement . Sociology of Health & Illness vol. 41 , ( 4 ) 755 - 771 .

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Abbott TEF, Pearse RM, Cuthbertson BH, Wijeysundera DN, Ackland GL ( 2019 ) . Cardiac vagal dysfunction and myocardial injury after non-cardiac surgery: a planned secondary analysis of the measurement of Exercise Tolerance before surgery study . British Journal of Anaesthesia

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Edwards MR, Pearse RM ( 2019 ) . Perioperative Haemodynamic Optimisation . Hemodynamic Monitoring , Springer Nature

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Fowler AJ, AHMAD T, ABBOTT T, TORRANCE H, PEARSE R, Wouters PF, De Hert S, Lobo SM et al. ( 2018 ) . Association of preoperative anaemia with postoperative morbidity and mortality: an observational cohort study in low-, middle-, and high-income countries . British Journal of Anaesthesia vol. 121 , ( 6 ) 1227 - 1235 .

Bloom B, Thomas S, Ahrensberg JM, Weaver R, Fowler A, Bestwick J, Harris T, Pearse R ( 2018 ) . A systematic review and meta-analysis of return to work after mild Traumatic brain injury . Brain Inj1 - 14 .

Shulman MA, Cuthbertson BH, Wijeysundera DN, Pearse RM, Thompson B, Torres E, Ambosta A, Wallace S et al. ( 2018 ) . Using the 6-minute walk test to predict disability-free survival after major surgery . British Journal of Anaesthesia vol. 122 , ( 1 ) 111 - 119 .

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TORRANCE H, LONGBOTTOM R, VIVIAN M, Lalabekyan B, ABBOTT TEF, ACKLAND GL, HINDS CJ, PEARSE RM et al. ( 2018 ) . Post-operative immune suppression is mediated via reversible, Interleukin-10 dependent pathways in circulating monocytes following major abdominal surgery . PLoS ONE vol. 13 , ( 9 )

Hewitt Smith A, Bulamba F, Olupot C, Musana F, Ochieng JP, Lipnick MS, Pearse RM ( 2018 ) . Surgical outcomes in eastern Uganda: A one-year cohort study . Southern African Journal of Anaesthesia and Analgesia vol. 24 , ( 5 ) 122 - 127 .

Neto AS, da Costa LGV, Hemmes SNT, Canet J, Hedenstierna G, Jaber S, Hiesmayr M, Hollmann MW et al. ( 2018 ) . The LAS VEGAS risk score for prediction of postoperative pulmonary complications . European Journal of Anaesthesiology vol. 35 , ( 9 ) 691 - 701 .

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Wijeysundera D, PEARSE R, shulman M, ABBOTT TEF, Torres E, Ambosta A, Bernard C, Granton J et al. ( 2018 ) . Assessment of functional capacity before major non-cardiac surgery: an international, prospective cohort study . Lancet vol. 391 , ( 10140 ) 2631 - 2640 .

WALKER S, ABBOTT TEF, Brown K, PEARSE R, ACKLAND G ( 2018 ) . Perioperative management of angiotensin-converting enzyme inhibitors and/or angiotensin receptor blockers: a survey of perioperative medicine practitioners . PeerJ

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Lurati Buse G, Manns B, Lamy A, Guyatt G, Polanczyk CA, Chan MTV, Wang CY, Villar JC et al. ( 2018 ) . Troponin T monitoring to detect myocardial injury after noncardiac surgery: a cost–consequence analysis . Canadian Journal of Surgery vol. 61 , ( 3 ) 185 - 194 .

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Buggy DJ, Freeman J, Johnson MZ, Leslie K, Riedel B, Sessler DI, Kurz A, Gottumukkala V et al. ( 2018 ) . Systematic review and consensus definitions for standardised endpoints in perioperative medicine: postoperative cancer outcomes . British Journal of Anaesthesia

ABBOTT TEF, Fowler A, Pelosi P, Garna de Abru M, Moller A, Canet J, Creagh-Brown B, Mythen M et al. ( 2018 ) . A systematic review and consensus definitions for standardised end-points in perioperative medicine: pulmonary complications . British Journal of Anaesthesia

Yeung J, Gillies MA, Pearse RM ( 2018 ) . Pragmatic trials in peri-operative medicine: why, when and how? . Anaesthesia

Simonis FD, Barbas CSV, Artigas-Raventós A, Canet J, Determann RM, Anstey J, Hedenstierna G, Hemmes SNT et al. ( 2018 ) . Potentially modifiable respiratory variables contributing to outcome in ICU patients without ARDS: a secondary analysis of PRoVENT . Annals of Intensive Care vol. 8 , ( 1 )

de Nadal M, Pérez-Hoyos S, Montejo-González JC, Pearse R, Aldecoa C, Spain OBOTESOSI ( 2018 ) . Intensive care admission and hospital mortality in the elderly after non-cardiac surgery . Medicina Intensiva (English Edition) vol. 42 , ( 8 ) 463 - 472 .

PROWLE JR ( 2018 ) . Acute Kidney Injury in Trauma Patients Admitted to Critical Care: Development and Validation of a Diagnostic Prediction Model . Scientific Reports

Vincent J-L, Einav S, Pearse R, Jaber S, Kranke P, Overdyk FJ, Whitaker DK, Gordo F et al. ( 2018 ) . Improving detection of patient deterioration in the general hospital ward environment . European Journal of Anaesthesiology vol. 35 , ( 5 ) 325 - 333 .

Kahan BC, Morris TP, Harris E, Pearse R, Hooper R, Eldridge S ( 2018 ) . Re-randomization increased recruitment and provided similar treatment estimates as parallel designs in trials of febrile neutropenia . Journal of Clinical Epidemiology vol. 97 , 14 - 19 .

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Wijeysundera DN, Pearse R, Shulman M, Abbott T, Grocott MP, Myles P, Cuthbertson B ( 2018 ) . ASSESSMENT OF FUNCTIONAL CAPACITY BEFORE MAJOR ELECTIVE NONCARDIAC SURGERY: AN INTERNATIONAL MULTICENTER PROSPECTIVE COHORT STUDY . ANESTHESIA AND ANALGESIA . vol. 126 , 585 - 587 .

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ABBOTT T, Ahmad T, Phull M, Fowler A, Hewson R, Biccard B, Chew M, Gillies M et al. ( 2018 ) . The surgical safety checklist and patient outcomes after surgery: a prospective observational cohort study, systematic review and meta-analysis . British Journal of Anaesthesia vol. 120 , ( 1 ) 146 - 155 .

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Skinner DL, de Vasconcellos K, Wise R, Esterhuizen TM, Fourie C, Mahomed AG, Gopalan PD, Joubert I et al. ( 2017 ) . Critical care admission of South African (SA) surgical patients: Results of the SA Surgical Outcomes Study . South African Medical Journal vol. 107 , ( 5 ) 411 - 419 .

Gillies MA, Lone NI, Pearse RM, Haddow C, Smyth L, Parks RW, Walsh TS, Harrison EM ( 2017 ) . Effect of day of the week on short- and long-term mortality after emergency general surgery . British Journal of Surgery vol. 104 , ( 7 ) 936 - 945 .

O'Connor ME, Hewson RW, Kirwan CJ, Ackland GL, Pearse RM, Prowle JR ( 2017 ) . Acute kidney injury and mortality 1 year after major non-cardiac surgery . British Journal of Surgery

Pearse RM, ABBOTT T, Haslop R, Ahmad T, Kahan BC, Filippini C, Rhodes A, Ranieri M ( 2017 ) . Prevention of Respiratory Insufficiency after Surgical Management (PRISM) trial: report of the protocol for a pragmatic randomised controlled trial of Continuous Positive Airway Pressure (CPAP) to prevent respiratory complications and improve survival following major abdominal surgery . Minerva Anestesiol vol. 83 , ( 2 ) 175 - 182 .

Bloom BM, Kinsella K, Pott J, Patel HC, Harris T, Lecky F, Pearse R ( 2017 ) . Short-term neurocognitive and symptomatic outcomes following mild traumatic brain injury: A prospective multi-centre observational cohort study . Brain Inj vol. 31 , ( 3 ) 304 - 311 .

Davenport RA, Guerreiro M, Frith D, Rourke C, Platton S, Cohen M, Pearse R, Thiemermann C et al. ( 2017 ) . Activated Protein C Drives the Hyperfibrinolysis of Acute Traumatic Coagulopathy . Anesthesiology vol. 126 , ( 1 ) 115 - 127 .

Gillies MA, Harrison EM, Pearse RM, Garrioch S, Haddow C, Smyth L, Parks R, Walsh TS et al. ( 2017 ) . Intensive care utilization and outcomes after high-risk surgery in Scotland: a population-based cohort study . British Journal of Anaesthesia vol. 118 , ( 1 ) 123 - 131 .

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Neto AS, Barbas CSV, Simonis FD, Artigas-Raventós A, Canet J, Determann RM, Anstey J, Hedenstierna G et al. ( 2016 ) . Epidemiological characteristics, practice of ventilation, and clinical outcome in patients at risk of acute respiratory distress syndrome in intensive care units from 16 countries (PRoVENT): an international, multicentre, prospective study . The Lancet Respiratory Medicine vol. 4 , ( 11 ) 882 - 893 .

Bos L, Schouten L, van Vught L, Wiewel M, Ong D, Cremer O, Artigas A, Martin-Loeches I et al. ( 2016 ) . ESICM LIVES 2016: part one . Intensive Care Medicine Experimental vol. 4 , ( Suppl 1 )

Longbottom ER, Torrance HDT, Owen HC, Fragkou PC, Hinds CJ, Pearse RM, O’Dwyer MJ ( 2016 ) . Features of Postoperative Immune Suppression Are Reversible With Interferon Gamma and Independent of Interleukin-6 Pathways . Annals of Surgery vol. 264 , ( 2 ) 370 - 377 .

Abbott TEF, Ackland GL, Archbold RA, Wragg A, Kam E, Ahmad T, Khan AW, Niebrzegowska E et al. ( 2016 ) . Preoperative heart rate and myocardial injury after non-cardiac surgery: results of a predefined secondary analysis of the VISION study . British Journal of Anaesthesia vol. 117 , ( 2 ) 172 - 181 .

Prowle JR, Kam EPY, Ahmad T, Smith NCE, Protopapa K, Pearse RM ( 2016 ) . Preoperative renal dysfunction and mortality after non-cardiac surgery . British Journal of Surgery vol. 103 , ( 10 ) 1316 - 1325 .

STARSurg Collaborative ( 2016 ) . Multicentre prospective cohort study of body mass index and postoperative complications following gastrointestinal surgery . British Journal of Surgery vol. 103 , ( 9 ) 1157 - 1172 .

Torrance HDT, Pearse RM, O'Dwyer MJ ( 2016 ) . Does major surgery induce immune suppression and increase the risk of postoperative infection? . Curr Opin Anaesthesiol vol. 29 , ( 3 ) 376 - 383 .

Jawad M, Baigi A, Oldner A, Pearse RM, Rhodes A, Seeman-Lodding H, Chew MS ( 2016 ) . Swedish surgical outcomes study (SweSOS) . European Journal of Anaesthesiology vol. 33 , ( 5 ) 317 - 325 .

Wijeysundera DN, Pearse RM, Shulman MA ( 2016 ) . Correction . BMJ Open vol. 6 , ( 4 )

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Wijeysundera DN, Pearse RM, Shulman MA, Abbott TEF, Torres E, Croal BL, Granton JT, Thorpe KE et al. ( 2016 ) . Measurement of Exercise Tolerance before Surgery (METS) study: a protocol for an international multicentre prospective cohort study of cardiopulmonary exercise testing prior to major non-cardiac surgery . BMJ Open vol. 6 , ( 3 ) e010359 - e010359 .

Ozdemir BA, Sinha S, Karthikesalingam A, Poloniecki JD, Pearse RM, Grocott MPW, Thompson MM, Holt PJE ( 2016 ) . Mortality of emergency general surgical patients and associations with hospital structures and processes . British Journal of Anaesthesia vol. 116 , ( 1 ) 54 - 62 .

Cecconi M, Hochrieser H, Chew M, Grocott M, Hoeft A, Hoste A, Jammer I, Posch M et al. ( 2016 ) . Preoperative abnormalities in serum sodium concentrations are associated with higher in-hospital mortality in patients undergoing major surgery . British Journal of Anaesthesia vol. 116 , ( 1 ) 63 - 69 .

Garrioch S, Lone N, Walsh T, Parks R, Pearse R, Smyth L, Haddow C, Gillies M ( 2016 ) . Short and long term outcome, critical care usage and predictors of mortality following emergency laparotomy in Scotland . ANAESTHESIA . vol. 71 , 64 - 64 .

Sadique Z, Harrison DA, Grieve R, Rowan KM, Pearse RM, for the OPTIMISE study group ( 2015 ) . Cost-effectiveness of a cardiac output-guided haemodynamic therapy algorithm in high-risk patients undergoing major gastrointestinal surgery . Perioperative Medicine vol. 4 , ( 1 )

Abbott T, Ackland GL, Wragg A, Rodseth R, Archbold A, Pearse RM ( 2015 ) . Association between intraoperative heart rate and postoperative myocardial injury in patients following non-cardiac surgery . Intensive Care Med Exp vol. 3 , ( Suppl 1 ) A751 - A751 .

Abbott T, Ackland G, Wragg A, Archbold A, Devereaux P, Pearse R ( 2015 ) . Association of preoperative heart rate with postoperative myocardial injury . BRITISH JOURNAL OF ANAESTHESIA . vol. 115 , E958 - E959 .

Jammer I, Ahmad T, Aldecoa C, Koulenti D, Goranovic T, Grigoras I, Mazul-Sunko B, Matas R et al. ( 2015 ) . Point Prevalence of Surgical Checklist Use in Europe . Survey of Anesthesiology vol. 59 , ( 6 ) 298 - 299 .

O’Connor ME, Kirwan CJ, Pearse RM, Prowle JR ( 2015 ) . Incidence and associations of acute kidney injury after major abdominal surgery . Intensive Care Medicine vol. 42 , ( 4 ) 521 - 530 .

Owen HC, Torrance HDT, Jones TF, Pearse RM, Hinds CJ, Brohi K, O’Dwyer MJ ( 2015 ) . Epigenetic regulatory pathways involving microRNAs may modulate the host immune response following major trauma . Journal of Trauma and Acute Care Surgery vol. 79 , ( 5 ) 766 - 772 .

Bloom BM, Maimaris C, Lecky F, Pearse R ( 2015 ) . Letter in Response to ‘Classification of Traumatic Brain Injury Severity Using Informed Data Reduction in a Series of Binary Classifier Algorithms’ . IEEE Transactions on Neural Systems and Rehabilitation Engineering vol. 24 , ( 5 ) 616 - 616 .

Raja M, Torrance H, Longbottom E, Stroud A, Vivian M, Zolfaghari P, Pearse R, Hinds C et al. ( 2015 ) . Long-Term Follow-Up of Sepsis Induced Immunoparalysis . Intensive Care Medicine Experimental vol. 3 , ( Suppl 1 )

Longbottom E, Torrance H, Owen H, Hinds C, Pearse R, O'Dwyer M ( 2015 ) . Post-operative immune suppression is reversible with interferon gamma and independent of IL-6 pathways . Intensive Care Medicine Experimental vol. 3 , ( Suppl 1 )

AHMAD T ( 2015 ) . Variation in haemodynamic monitoring for major surgery in European nations: secondary analysis of the EuSOS dataset . Perioperative Medicine vol. 4 , ( 8 )

Fowler AJ, Ahmad T, Phull MK, Allard S, Gillies MA, Pearse RM ( 2015 ) . Meta-analysis of the association between preoperative anaemia and mortality after surgery . British Journal of Surgery vol. 102 , ( 11 ) 1314 - 1324 .

Pearse RM, Wijeysundera DN ( 2015 ) . Steroids for cardiac surgery: has the story finally ended? . The Lancet vol. 386 , ( 10000 ) 1215 - 1216 .

Gillies MA, Shah AS, Mullenheim J, Tricklebank S, Owen T, Antonelli J, Strachan F, Mills NL et al. ( 2015 ) . Perioperative myocardial injury in patients receiving cardiac output-guided haemodynamic therapy: a substudy of the OPTIMISE Trial . British journal of anaesthesia vol. 115 , ( 2 ) 227 - 233 .

Gillies MA, Power GS, Harrison DA, Fleming A, Cook B, Walsh TS, Pearse RM, Rowan KM ( 2015 ) . Regional variation in critical care provision and outcome after high-risk surgery . Intensive Care Medicine vol. 41 , ( 10 ) 1809 - 1816 .

Abbott T, Rodseth R, Le Manach Y, Ackland G, Archbold A, Wragg A, Devereaux P, Pearse R ( 2015 ) . Association between preoperative resting heart rate and postoperative myocardial injury in patients undergoing non-cardiac surgery . ANAESTHESIA . vol. 70 , 28 - 28 .

Baron DM, Hochrieser H, Posch M, Metnitz B, Rhodes A, Moreno RP, Pearse RM, Metnitz P ( 2015 ) . Preoperative Anaemia Is Associated With Poor Clinical Outcome in Non-cardiac Surgery Patients . Survey of Anesthesiology vol. 59 , ( 3 )

van Zaane B, van Klei WA, Buhre WF, Bauer P, Boerma EC, Hoeft A, Metnitz P, Moreno RP et al. ( 2015 ) . Nonelective surgery at night and in-hospital mortality: Prospective observational data from the European Surgical Outcomes Study . European journal of anaesthesiology vol. 32 , ( 7 ) 477 - 485 .

Vincent J-L, Pelosi P, Pearse R, Payen D, Perel A, Hoeft A, Romagnoli S, Ranieri VM et al. ( 2015 ) . Perioperative cardiovascular monitoring of high-risk patients: a consensus of 12 . CRITICAL CARE vol. 19 , Article ARTN 224 ,

Bloom BM, Maimaris C, Lecky F, Pearse R ( 2015 ) . Letter in response to 'Classification algorithms for the identification of structural injury in TBI using brain electrical activity' . Computers in biology and medicine

Freund Y, Bloom B, Bokobza J, Baarir N, Laribi S, Harris T, Navarro V, Bernard M et al. ( 2015 ) . Predictive value of S100-B and copeptin for outcomes following seizure: the BISTRO International Cohort Study . PloS one vol. 10 , ( 4 ) e0122405 - e0122405 .

Torrance HD, Brohi K, Pearse RM, Mein CA, Wozniak E, Prowle JR, Hinds CJ, O'Dwyer MJ ( 2015 ) . Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured polytrauma patients . Annals of Surgery vol. 261 , ( 4 ) 751 - 759 .

Torrance HD, Brohi K, Pearse RM, Mein CA, Wozniak E, Prowle JR, Hinds CJ, OʼDwyer MJ ( 2015 ) . Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured polytrauma patients . Ann Surg vol. 261 , ( 4 ) 751 - 759 .

Ackland GL, Cecconi M, Pearse RM ( 2015 ) . Individualised targeted haemodynamic therapy in high-risk surgical patients - authors' reply . The Lancet. Respiratory medicine vol. 3 , ( 4 ) e14 - e15 .

Jammer I, Wickboldt N, Sander M, Smith A, Schultz MJ, Pelosi P, Leva B, Rhodes A et al. ( 2015 ) . Standards for definitions and use of outcome measures for clinical effectiveness research in perioperative medicine: European Perioperative Clinical Outcome (EPCO) definitions: a statement from the ESA-ESICM joint taskforce on perioperative outcome measures . Eur J Anaesthesiol vol. 32 , ( 2 ) 88 - 105 .

Jammer I, Ahmad T, Aldecoa C, Koulenti D, Goranović T, Grigoras I, Mazul-Sunko B, Matos R et al. ( 2015 ) . Point prevalence of surgical checklist use in Europe: relationship with hospital mortality . British Journal of Anaesthesia vol. 114 , ( 5 ) 801 - 807 .

Al-Khafaji A, Elder M, Lebovitz DJ, Murugan R, Souter M, Stuart S, Wahed AS, Keebler B et al. ( 2015 ) . Protocolized fluid therapy in brain-dead donors: the multicenter randomized MOnIToR trial . Intensive Care Medicine vol. 41 , ( 3 ) 418 - 426 .

Torrance HD, Vivian ME, Brohi K, Prowle JR, Pearse RM, Owen HC, Hinds CJ, O'Dwyer MJ ( 2015 ) . Changes in gene expression following trauma are related to the age of transfused packed red blood cells . J Trauma Acute Care Surg vol. 78 , ( 3 ) 535 - 542 .

Vellinga NAR, Boerma EC, Koopmans M, Donati A, Dubin A, Shapiro NI, Pearse RM, Machado FR et al. ( 2015 ) . International Study on Microcirculatory Shock Occurrence in Acutely Ill Patients* . Critical Care Medicine vol. 43 , ( 1 ) 48 - 56 .

Moreno RP, Pearse R, Rhodes A ( 2015 ) . O escore da American Society of Anesthesiologists: ainda útil após 60 anos? Resultados do estudo EuSOS . Revista Brasileira de Terapia Intensiva vol. 27 , ( 2 ) 105 - 112 .

Pearse RM ( 2015 ) . The whole truth and nothing but the truth: the need for full reporting of randomised trials . Perioperative medicine (London, England) vol. 4 , 7 - 7 .

Ackland GL, Iqbal S, Paredes LG, Toner A, Lyness C, Jenkins N, Bodger P, Karmali S et al. ( 2014 ) . Individualised oxygen delivery targeted haemodynamic therapy in high-risk surgical patients: a multicentre, randomised, double-blind, controlled, mechanistic trial . The Lancet Respiratory Medicine vol. 3 , ( 1 ) 33 - 41 .

MacDonald N, Ahmad T, Mohr O, Kirk-Bayley J, Moppett I, Hinds CJ, Pearse RM ( 2014 ) . Dynamic preload markers to predict fluid responsiveness during and after major gastrointestinal surgery: an observational substudy of the OPTIMISE trial . British Journal of Anaesthesia vol. 114 , ( 4 ) 598 - 604 .

Pearse RM, MacDonald N, Grocott MPW, OPTIMISE Study Group ( 2014 ) . Use of hemodynamic algorithm after gastrointestinal surgery--reply . JAMA vol. 312 , ( 14 )

Freund Y, Blooom B, Bokobza J, Baarir N, Laribi S, Harris T, Navarro V, Pearse R et al. ( 2014 ) . 19 Short Term Recurrence and Severe Outcome Following Emergency Department Visit for Seizure: Results from the BISTRO International Prospective Trial . Annals of Emergency Medicine vol. 64 , ( 4 )

Chappell D, Jacob M ( 2014 ) . A rational approach to fluid and volume management . Perioperative Hemodynamic Monitoring and Goal Directed Therapy , Cambridge University Press (CUP)

Edison E, Rhodes A ( 2014 ) . Goal directed therapy in the perioperative setting: what is the evidence? . Perioperative Hemodynamic Monitoring and Goal Directed Therapy , Cambridge University Press (CUP)

Kam E, Pearse R ( 2014 ) . Patient outcome following major surgery . Perioperative Hemodynamic Monitoring and Goal Directed Therapy , Cambridge University Press (CUP)

Carter A, Pearse R ( 2014 ) . ScvO2 monitoring . Perioperative Hemodynamic Monitoring and Goal Directed Therapy , Cambridge University Press (CUP)

Baron DM, Hochrieser H, Posch M, Metnitz B, Rhodes A, Moreno RP, Pearse RM, Metnitz P et al. ( 2014 ) . Preoperative anaemia is associated with poor clinical outcome in non-cardiac surgery patients . Br J Anaesth vol. 113 , ( 3 ) 416 - 423 .

Torrance HD, Brohi K, Pearse RM, Mein CA, Wozniak E, Prowle JR, Hinds CJ, O’Dwyer MJ ( 2014 ) . Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured polytrauma patients . Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine . vol. 22 ,

Prowle JR, Kolic I, Purdell-Lewis J, Taylor R, Pearse RM, Kirwan CJ ( 2014 ) . Serum creatinine changes associated with critical illness and detection of persistent renal dysfunction after AKI . Clin J Am Soc Nephrol vol. 9 , ( 6 ) 1015 - 1023 .

Pearse RM, Harrison DA, MacDonald N, Gillies MA, Blunt M, Ackland G, Grocott MPW, Ahern A et al. ( 2014 ) . Effect of a perioperative, cardiac output-guided hemodynamic therapy algorithm on outcomes following major gastrointestinal surgery: a randomized clinical trial and systematic review . JAMA vol. 311 , ( 21 ) 2181 - 2190 .

Hemmes SNT, Gama de Abreu M, Pelosi P, Schultz MJ ( 2014 ) . High versus low positive end-expiratory pressure during general anaesthesia for open abdominal surgery (PROVHILO trial): a multicentre randomised controlled trial . The Lancet vol. 384 , ( 9942 ) 495 - 503 .

Fragkou P, Torrance H, Ackland G, Hinds C, Pearse R, O'Dwyer MJ ( 2014 ) . Major gastrointestinal surgery is associated with a specific gene expression profile that is quantitatively associated with infectious complications . European Journal of Anaesthesiology . vol. 31 ,

Fragkou P, Prowle J, Ackland G, Hinds C, Pearse R, O'Dwyer MJ ( 2014 ) . Perioperative blood transfusion is associated with a characteristic immune response, excess infectious complications and death in patients undergoing scheduled major gastrointestinal surgery . European Journal of Anaesthesiology . vol. 31 ,

Jawad M, Pearse R, Rhodes A, SeemanLodding H, Baigi A, Chew MS ( 2014 ) . Swedish Surgical Outcome Study (SweSOS), a sub study of the European Surgical Outcomes Study (EuSOS). Characteristics and outcome of the Swedish subset of EuSOS to identify the predictors of short- and long-term mortality in Sweden. Analytical, descriptive and prospective cohort study . European Journal of Anaesthesiology . vol. 31 , 248 - 249 .

Reynolds TE, Pearse RM ( 2014 ) . Cardiac troponins in sepsis: an indication for echocardiography?* . Crit Care Med vol. 42 , ( 4 ) 975 - 976 .

James S, Jhanji S, Smith A, O'Brien G, Fitzgibbon M, Pearse RM ( 2014 ) . Comparison of the prognostic accuracy of scoring systems, cardiopulmonary exercise testing, and plasma biomarkers: a single-centre observational pilot study . Br J Anaesth vol. 112 , ( 3 ) 491 - 497 .

Botto F, Alonso-Coello P, Chan MTV, Villar JC, Xavier D, Srinathan S, Guyatt G, Cruz P et al. ( 2014 ) . Myocardial Injury after Noncardiac Surgery . Anesthesiology vol. 120 , ( 3 ) 564 - 578 .

Torrance HDT, Brohi K, Pearse RM, Mein CA, Wozniak E, Prowle JR, Hinds CJ, O’Dwyer MJ ( 2014 ) . Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured polytrauma patients . Scandinavian journal of trauma, resuscitation and emergency medicine vol. 22 , ( Suppl 1 ) O7 - O7 .

Pearse RM ( 2014 ) . Effect of a Perioperative, Cardiac Output-Guided Hemodynamic Therapy Algorithm on Outcomes Following Major Gastrointestinal Surgery: A Randomized Clinical Trial and Systematic Review (vol 311, pg 2181, 2014) . JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION vol. 312 , ( 14 ) 1473 - 1473 .

Macdonald N, Pearse R ( 2014 ) . Effect of a perioperative haemodynamic therapy algorithm on outcomes after major gastrointestinal surgery: a multi-centre randomized controlled trial . BRITISH JOURNAL OF ANAESTHESIA . vol. 112 , 190P - 190P .

Dreyer G, Tucker AT, Harwood SM, Pearse RM, Raftery MJ, Yaqoob MM ( 2014 ) . Ergocalciferol and microcirculatory function in chronic kidney disease and concomitant vitamin d deficiency: an exploratory, double blind, randomised controlled trial . PLoS One vol. 9 , ( 7 )

Gillies MA, Habicher M, Jhanji S, Sander M, Mythen M, Hamilton M, Pearse RM ( 2014 ) . Incidence of postoperative death and acute kidney injury associated with i.v. 6 hydroxyethyl starch use: systematic review and meta-analysis . BRITISH JOURNAL OF ANAESTHESIA vol. 112 , ( 1 ) 25 - 34 .

Kam E, Pearse R ( 2014 ) . Patient outcome following major surgery . Paradise Lost and the Cosmological Revolution ,

Fragkou PC, Torrance HD, Pearse RM, Ackland GL, Prowle JR, Owen HC, Hinds CJ, O'Dwyer MJ ( 2014 ) . Perioperative blood transfusion is associated with a gene transcription profile characteristic of immunosuppression: a prospective cohort study . Crit Care vol. 18 , ( 5 ) 014 - 0541 .

Cannesson M, Pearse R ( 2014 ) . Perioperative hemodynamic monitoring and goal directed therapy: From theory to practice .

Vivian M, Torrance HDT, Pearse R, Brohi K, Hinds CJ, O'Dwyer MJ ( 2014 ) . THE AGE OF TRANSFUSED PACKED RED BLOOD CELLS CORRELATES WITH THE DEGREE OF IMMUNOSUPPRESSION AS ASSESSED BY GENE EXPRESSION PATTERNS IN SEVERELY INJURED TRAUMA PATIENTS . INTENSIVE CARE MEDICINE . vol. 40 , S20 - S20 .

Pearse R, Hoeft A, Moreno RP, Pelosi P, Rhodes A ( 2013 ) . Mortality after surgery in Ireland - Authors' reply . Lancet vol. 382 , ( 9910 ) 2063 - 2064 .

Al-Khafaji A, Murugan R, Wahed AS, Lebovitz DJ, Souter MJ, Kellum JA ( 2013 ) . Monitoring Organ Donors to Improve Transplantation Results (MOnIToR) trial methodology . Critical Care and Resuscitation vol. 15 , ( 3 ) 234 - 240 .

Cullen, Jhanji S, Pearse R, Fitzgibbon M ( 2013 ) . Neutrophil gelatinase-associated lipocalin and albuminuria as predictors of acute kidney injury in patients treated with goal-directed haemodynamic therapy after major abdominal surgery . Annals of Clinical Biochemistry International Journal of Laboratory Medicine vol. 51 , ( 3 ) 392 - 399 .

Walsh TS, Boyd JA, Watson D, Hope D, Lewis S, Krishan A, Forbes JF, Ramsay P et al. ( 2013 ) . Restrictive Versus Liberal Transfusion Strategies for Older Mechanically Ventilated Critically Ill Patients . Critical Care Medicine vol. 41 , ( 10 ) 2354 - 2363 .

Lee GR, Jhanji S, Tarrant H, James S, Pearse RM, Fitzgibbon M ( 2013 ) . Peri-operative troponin monitoring using a prototype high-sensitivity cardiac troponin I (hs-cTnI) assay: comparisons with hs-cTnT and contemporary cTnI assays . Annals of Clinical Biochemistry International Journal of Laboratory Medicine vol. 51 , ( 2 ) 258 - 268 .

Reynolds T, Vivian-Smith A, Jhanji S, Pearse RM ( 2013 ) . Observational study of the effects of age, diabetes mellitus, cirrhosis and chronic kidney disease on sublingual microvascular flow . Perioper Med (Lond) vol. 2 , ( 1 )

Bangash MN, Patel NSA, Benetti E, Collino M, Hinds CJ, Thiemermann C, Pearse RM ( 2013 ) . Dopexamine can attenuate the inflammatory response and protect against organ injury in the absence of significant effects on hemodynamics or regional microvascular flow . Crit Care vol. 17 , ( 2 )

Prowle JR, Pearse RM ( 2013 ) . Is it the end of the road for synthetic starches in critical illness? . The BMJ vol. 346 , ( mar20 1 )

Reynolds T, Jhanji S, Vivian-Smith A, Pearse R ( 2013 ) . Observational study of the effects of age, diabetes mellitus, cirrhosis and chronic kidney disease on sublingual microvascular flow . Critical Care vol. 17 , ( Suppl 2 )

Pearse R, Moreno RP, Bauer P, Pelosi P, Metnitz P, Spies C, Vallet B, Vincent J-L et al. ( 2013 ) . Mortality after surgery in Europe – Authors' reply . The Lancet vol. 381 , ( 9864 ) 370 - 371 .

Torrance HDT, Brohi K, Pearse RM, Fragkou P, Hinds CJ, O'Dwyer MJ ( 2013 ) . BLOOD TRANSFUSION FOLLOWING SEVERE TRAUMA IS ASSOCIATED WITH THE DEVELOPMENT OF AN EARLY ANTI-INFLAMMATORY RESPONSE . INTENSIVE CARE MEDICINE . vol. 39 , S386 - S387 .

Baron DM, Hochrieser H, Metnitz B, Rhodes A, Moreno RP, Pearse RM, Metnitz P ( 2013 ) . PREOPERATIVE ANEMIA AND POLYCYTHEMIA ARE ASSOCIATED WITH A HIGHER IN-HOSPITAL MORTALITY IN NON-CARDIAC SURGERY PATIENTS . INTENSIVE CARE MEDICINE . vol. 39 , S285 - S285 .

Cecconi M, Hochrieser H, Metnitz B, Moreno R, Pearse R, Metnitz P, Rhodes A ( 2013 ) . PREOPERATVE SERUM SODIUM AND POSTOPERATIVE MORTALITY: A EUSOS SUBSTUDY . INTENSIVE CARE MEDICINE . vol. 39 , S337 - S338 .

Pearse RM, van Zaane B, Moreno RP, Buhre WF, van Klei WA, Rhodes A ( 2013 ) . START TIMES OF EMERGENCY SURGERY AND IN HOSPITAL MORTALITY: A COHORT STUDY ON THE EUSOS DATABASE COMPARING MORTALITY AFTER DAY SHIFT, EVENING SHIFT AND NIGHT SHIFT PROCTDURES . INTENSIVE CARE MEDICINE . vol. 39 , S349 - S349 .

Diogo AC, Iannuccelli F, Rhodes A, Pearse R, Moreno R ( 2013 ) . THE RELATIONSHIP BETWEEN THE ASA SCORE AND OUTCOME FROM SURGERY. RESULTS FROM THE EUSOS STUDY . INTENSIVE CARE MEDICINE . vol. 39 , S349 - S349 .

Retter A, Wyncoll D, Pearse R, Carson D, McKechnie S, Stanworth S, Allard S, Thomas D et al. ( 2012 ) . Guidelines on the management of anaemia and red cell transfusion in adult critically ill patients . British Journal of Haematology vol. 160 , ( 4 ) 445 - 464 .

Ford SR, Pearse RM ( 2012 ) . Do integrated care pathways have a place in critical care? . Curr Opin Crit Care vol. 18 , ( 6 ) 683 - 687 .

Pearse RM, Moreno RP, Bauer P, Pelosi P, Metnitz P, Spies C, Vallet B, Vincent J-L et al. ( 2012 ) . Mortality after surgery in Europe: a 7 day cohort study . Lancet vol. 380 , ( 9847 ) 1059 - 1065 .

Young EL, Huddart S, Pearse RP, Karthikesalingam A, Hinchliffe RJ, Loftus IM, Thompson MM, Holt PJE ( 2012 ) . Reply to ‘Comment on a Systematic Review of the Role of Cardiopulmonary Exercise Testing in Vascular Surgery’ . European Journal of Vascular and Endovascular Surgery vol. 44 , ( 3 ) 350 - 351 .

Pearse RM, Ackland GL ( 2012 ) . [Perioperative fluid therapy] . Praxis (Bern 1994) vol. 101 , ( 17 ) 1113 - 1118 .

McGinley A, Pearse RM ( 2012 ) . A national early warning score for acutely ill patients . The BMJ vol. 345 , ( aug08 1 )

( 2012 ) . Error in Viewpoint in: Statin Therapy for Healthy Men Identified as ‘Increased Risk,’ . JAMA vol. 307 , ( 24 ) 2590 - 2590 .

( 2012 ) . Incomplete Results Data in: Association Between Postoperative Troponin Levels and 30-Day Mortality Among Patients Undergoing Noncardiac Surgery . JAMA vol. 307 , ( 24 ) 2590 - 2590 .

Vellinga NAR, Boerma EC, Koopmans M, Donati A, Dubin A, Shapiro NI, Pearse RM, Bakker J et al. ( 2012 ) . Study Design of the Microcirculatory Shock Occurrence in Acutely Ill Patients (microSOAP): an International Multicenter Observational Study of Sublingual Microcirculatory Alterations in Intensive Care Patients . Critical Care Research and Practice vol. 2012 , ( 1 )

Pearse RM, Ackland GL ( 2012 ) . Perioperative fluid therapy . BMJ vol. 344 ,

Young EL, Karthikesalingam A, Huddart S, Pearse RM, Hinchliffe RJ, Loftus IM, Thompson MM, Holt PJE ( 2012 ) . A Systematic Review of the Role of Cardiopulmonary Exercise Testing in Vascular Surgery . European Journal of Vascular and Endovascular Surgery vol. 44 , ( 1 ) 64 - 71 .

Bangash MN, Kong M-L, Pearse RM ( 2012 ) . Use of inotropes and vasopressor agents in critically ill patients . Br J Pharmacol vol. 165 , ( 7 ) 2015 - 2033 .

Devereaux PJ, Chan MT, Alonso-Coello P, Walsh M, Berwanger O, Villar JC, Wang CY, Garutti RI et al. ( 2012 ) . Association between postoperative troponin levels and 30-day mortality among patients undergoing noncardiac surgery . JAMA: Journal of the American Medical Association vol. 307 , ( 21 ) 2295 - 2304 .

Frith D, Guerreiro M, Pearse R, Thiemermann C, Brohi K ( 2012 ) . EXPERIMENTAL ACUTE TRAUMATIC COAGULOPATHY IS ASSOCIATED WITH MODERATE IMPAIRMENT OF THROMBIN GENERATION AND DYSFIBRINOGENEMIA . SHOCK . vol. 37 , 34 - 34 .

( 2012 ) . IC . Encyclopedia of Intensive Care Medicine , Springer Nature

Hewson R, Pearse RM ( 2012 ) . Inotropic Therapy . Encyclopedia of Intensive Care Medicine , Springer Nature

Bangash MN, Pearse RM ( 2012 ) . Microcirculation . Encyclopedia of Intensive Care Medicine , Springer Nature

Grocott MPW, Pearse RM ( 2012 ) . Perioperative medicine: the future of anaesthesia? . BRITISH JOURNAL OF ANAESTHESIA vol. 108 , ( 5 ) 723 - 726 .

Terblanche M, Kruger P, di Gangi S, Gearay S, Gilfeather L, Ferguson ND, Pearse R, Beale R et al. ( 2012 ) . Risk factors for acute organ failure in intensive care unit patients who receive respiratory support in the absence of non-respiratory organ failure: an international prospective cohort study . CRITICAL CARE vol. 16 , ( 2 ) Article ARTN R61 ,

Davenport R, Manson J, De'Ath H, Platton S, Coates A, Allard S, Hart D, Pearse R et al. ( 2011 ) . Functional definition and characterization of acute traumatic coagulopathy . Crit Care Med vol. 39 , ( 12 ) 2652 - 2658 .

Pearse R, Holt P, Grocott M ( 2011 ) . Authors' reply to Petros and colleagues . BMJ (Online) vol. 343 , ( 7833 )

Pearse RM, Holt PJE, Grocott MPW ( 2011 ) . Managing perioperative risk in patients undergoing elective non-cardiac surgery . BMJ vol. 343 ,

MacDonald N, Pearse RM ( 2011 ) . Peri-operative hemodynamic therapy: only large clinical trials can resolve our uncertainty . Crit Care vol. 15 , ( 3 )

Pearse RM, Rhodes A, Moreno R, Pelosi P, Spies C, Vallet B, Metnitz P, Bauer P et al. ( 2011 ) . EuSOS: European surgical outcomes study . Eur J Anaesthesiol vol. 28 , ( 6 ) 454 - 456 .

Kavsak PA, Walsh M, Srinathan S, Thorlacius L, Buse GL, Botto F, Pettit S, McQueen MJ et al. ( 2011 ) . High sensitivity troponin T concentrations in patients undergoing noncardiac surgery: A prospective cohort study . Clinical Biochemistry vol. 44 , ( 12 ) 1021 - 1024 .

Correa T, Kindler R, Brandt S, Gorrasi J, Regueira T, Bracht H, Porta F, Takala J et al. ( 2011 ) . Impact of hepatic venous oxygen efflux and carotid blood flow on the difference between mixed and central venous oxygen saturation . Critical Care vol. 15 , ( Suppl 1 )

Pearse R, Holt P, Grocott M ( 2011 ) . Authors' reply to Petros and colleagues . BMJ vol. 343 ,

Frith D, Baptista ML, Cohen MJ, Pearse R, Thiemermann C, Brohi K ( 2011 ) . EXPERIMENTAL ACUTE TRAUMATIC COAGULOPATHY: INITIATED BY HYPOPERFUSION, MODULATED BY THE PROTEIN C PATHWAY . SHOCK vol. 36 , 16 - 17 .

Frith D, Baptista ML, Cohen M, Pearse R, Thiemermann C, Brohi K ( 2011 ) . Experimental acute traumatic coagulopathy is due to systemic activation of protein c during hypoperfusion . JOURNAL OF THROMBOSIS AND HAEMOSTASIS vol. 9 , 481 - 481 .

Davenport R, Curry N, Manson J, De'Ath H, Coates A, Rourke C, Pearse R, Stanworth S et al. ( 2011 ) . Hemostatic effects of fresh frozen plasma may be maximal at red cell ratios of 1:2 . J Trauma vol. 70 , ( 1 ) 90 - 95 .

James S, Jhanji S, Niebrzegowska E, Tarrell T, Smith AV, Pearse R ( 2011 ) . PERI-OPERATIVE MICROVASCULAR FLOW AND CARDIO-PULMONARY EXERCISE TESTLNG IN HIGH RISK SURGICAL PATIENTS . INTENSIVE CARE MEDICINE . vol. 37 , S132 - S132 .

Davenport R, Manson J, De'Ath H, Platton S, Coates A, Allard S, Hart D, Pearse R et al. ( 2011 ) . Point of care diagnostics for the rapid identification of acute traumatic coagulopathy and prediction of massive trauma haemorrhage . BRITISH JOURNAL OF SURGERY . vol. 98 , 7 - 7 .

Martin-Loeches I, Lisboa T, Rhodes A, Moreno RP, Silva E, Sprung C, Chiche JD, Barahona D et al. ( 2010 ) . Use of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1)v influenza A infection . Intensive Care Medicine vol. 37 , ( 2 ) 272 - 283 .

Grocott MPW, Pearse RM ( 2010 ) . Prognostic studies of perioperative risk: robust methodology is needed . British Journal of Anaesthesia vol. 105 , ( 3 ) 243 - 245 .

Pearse RM ( 2010 ) . Another inconvenient truth: meeting the challenge of preventing poor surgical outcomes . Current Opinion in Critical Care vol. 16 , ( 4 ) 337 - 338 .

( 2010 ) . Editorial introductions . Current Opinion in Critical Care vol. 16 , ( 4 )

Rampal T, Jhanji S, Pearse RM ( 2010 ) . Using oxygen delivery targets to optimize resuscitation in critically ill patients . Curr Opin Crit Care vol. 16 , ( 3 ) 244 - 249 .

Spanos A, Jhanji S, Vivian-Smith A, Harris T, Pearse RM ( 2010 ) . EARLY MICROVASCULAR CHANGES IN SEPSIS AND SEVERE SEPSIS . SHOCK vol. 33 , ( 4 ) 387 - 391 .

Pearse RM ( 2010 ) . Water, taken in moderation, cannot hurt anybody (Mark Twain 1835-1910) . J PHYSIOL-LONDON vol. 588 , ( 2 ) 281 - 282 .

Frith D, Stanworth S, Gaarder C, Maegele M, Goslings C, Johansson P, Allard S, Cohen M et al. ( 2010 ) . Acute traumatic coagulopathy is dependent upon injury load and shock . BRITISH JOURNAL OF SURGERY vol. 97 , 39 - 40 .

Jhanji S, Vivian-Smith A, Lucena-Amaro S, Watson D, Hinds CJ, Pearse RM ( 2010 ) . Haemodynamic optimisation improves tissue microvascular flow and oxygenation after major surgery: a randomised controlled trial . Crit Care vol. 14 , ( 4 )

Frith D, Cohen M, Pearse R, Thiemermann C, Brohi K ( 2010 ) . Rodent coagulation responses to trauma and haemorrhagic shock . INFLAMMATION RESEARCH . vol. 59 , S26 - S27 .

Martin-Loeches I, Lisboa T, Rhodes A, Moreno R, Silva E, Sprung C, Chiche J, Barahona D et al. ( 2010 ) . USE OF CORTICOSTEROID THERAPY IN PATIENTS AFFECTED BY SEVERE PANDEMIC (H1N1)V INFLUENZA A INFECTION . INTENSIVE CARE MEDICINE . vol. 36 , S319 - S319 .

Pearse R, Bennett D, Hinds C ( 2009 ) . Dopexamine and survival: areas of consistency . Anaesthesia vol. 64 , ( 11 ) 1258 - 1258 .

Jhanji S, Vivian-Smith A, Lucena-Amaro S, Watson D, Hinds CJ, Pearse RM ( 2009 ) . A RANDOMISED CONTROLLED TRIAL OF THE EFFECTS OF POST-OPERATIVE HAEMODYNAMIC OPTIMISATION ON MICROVASCULAR FLOW, TISSUE OXYGENATION AND INFLAMMATORY MARKERS AFTER MAJOR ABDOMINAL SURGERY . INTENSIVE CARE MEDICINE . vol. 35 , 213 - 213 .

Shepherd SJ, Pearse RM ( 2009 ) . Role of Central and Mixed Venous Oxygen Saturation Measurement in Perioperative Care . ANESTHESIOLOGY vol. 111 , ( 3 ) 649 - 656 .

Jhanji S, Pearse RM ( 2009 ) . The use of early intervention to prevent postoperative complications . Curr Opin Crit Care vol. 15 , ( 4 ) 349 - 354 .

Powell-Tuck J, Gosling P, Lobo DN, Carlson GL, Allison SP, Gore M, Lewington AJ, Pearse RL et al. ( 2009 ) . Authors of guideline respond . The BMJ vol. 339 , ( jul28 3 )

Jhanji S, Stirling S, Patel N, Hinds CJ, Pearse RM ( 2009 ) . The effect of increasing doses of norepinephrine on tissue oxygenation and microvascular flow in patients with septic shock . Crit Care Med vol. 37 , ( 6 ) 1961 - 1966 .

Jhanji S, Lee C, Watson D, Hinds C, Pearse RM ( 2009 ) . Microvascular flow and tissue oxygenation after major abdominal surgery: association with post-operative complications . Intensive Care Med vol. 35 , ( 4 ) 671 - 677 .

Frith D, Chesebro B, Pittet JF, Cohen MJ, Thiemermann C, Pearse R, Brohi K ( 2009 ) . ACUTE TRAUMATIC COAGULOPATHY IS DRIVEN BY SYSTEMIC HYPOPERFUSION INDEPENDENT OF HYPOTENSION AND HAEMORRHAGE VOLUME . SHOCK . vol. 32 , 9 - 9 .

Maddison B, Wolff C, Findlay G, Radermacher P, Hinds C, Pearse RM ( 2009 ) . Comparison of three methods of extravascular lung water volume measurement in patients after cardiac surgery . Crit Care vol. 13 , ( 4 )

Jhanji S, Stirling S, Patel NSA, Hinds CJ, Pearse RM ( 2009 ) . EFFECT OF INCREASING DOSES OF NOREPINEPHRINE ON TISSUE OXYGENATION AND MICROVASCULAR PERFUSION IN SEPTIC SHOCK . SHOCK . vol. 32 , 2 - 2 .

Pearse RM ( 2009 ) . Extending the role of lactate measurement into the prehospital environment . Crit Care vol. 13 , ( 1 )

Morris CG, Pearse RM ( 2009 ) . Pro-Con Debate: We should not Measure Cardiac output in Critical Care . Journal of the Intensive Care Society vol. 10 , ( 1 ) 8 - 12 .

Powell-Tuck J, Allison SP, Gosling P, Lobo DN, Carlson GL, Gore M, Lewington AJ, Pearse RM et al. ( 2009 ) . Summary of the British Consensus Guidelines on Intravenous Fluid Therapy for Adult Surgical Patients (GIFTASUP) – For Comment . Journal of the Intensive Care Society vol. 10 , ( 1 ) 13 - 15 .

Davenport R, Coates A, Allard S, Pasi J, MacCallum P, Stanworth S, Thiemermann C, Pearse R et al. ( 2009 ) . TRAUMA HAEMORRHAGE: EVOLVING ROLE OF ROTEM FOR PREDICTING TRANSFUSION REQUIREMENTS . SHOCK . vol. 32 , 15 - 15 .

Maddison B, Giudici R, Calzia E, Wolff C, Hinds C, Radermacher P, Pearse RM ( 2008 ) . Extravascular lung water volume measurement by a novel lithium-thermal indicator dilution method: comparison of three techniques to post-mortem gravimetry . Intensive Care Med vol. 34 , ( 11 ) 2106 - 2111 .

Pearse R ( 2008 ) . Inadequate pre‐operative evaluation and preparation 1 . Anaesthesia vol. 56 , ( 4 ) 374 - 374 .

Nourse S, Hurding A, McGinley A, Mandersloot G, Pearse R ( 2008 ) . Association between Cardiac Index and Mortality in Patients Assessed on the Ward by a Nurse-Led Critical Care Outreach Team . Journal of the Intensive Care Society vol. 9 , ( 2 ) 118 - 123 .

Jhanji S, Thomas B, Ely A, Watson D, Hinds CJ, Pearse RM ( 2008 ) . Mortality and utilisation of critical care resources amongst high-risk surgical patients in a large NHS trust . Anaesthesia vol. 63 , ( 7 ) 695 - 700 .

Pearse RM, Belsey JD, Cole JN, Bennett ED ( 2008 ) . Effect of dopexamine infusion on mortality following major surgery: Individual patient data meta-regression analysis of published clinical trials . CRIT CARE MED vol. 36 , ( 4 ) 1323 - 1329 .

Maddison B, Wolff C, Findlay G, Calzia E, Hinds C, Pearse R ( 2008 ) . Intrathoracic blood volume measurement: comparison of transpulmonary lithium indicator dilution with indocyanine green indicator dilution . Critical Care vol. 12 , ( Suppl 2 )

Jhanji S, Dawson J, Pearse RM ( 2008 ) . Cardiac output monitoring: basic science and clinical application . Anaesthesia vol. 63 , ( 2 ) 172 - 181 .

Maddison B, Findlay G, Radermacher P, Hinds C, Pearse RM ( 2008 ) . Intrathoracic blood volume measurement: A comparison of transpulmonary lithium indicator dilution with indocyanine green indicator dilution . SHOCK . vol. 29 , 63 - 63 .

Pearse RM, Langford RM ( 2008 ) . Perioperative management of the high-risk surgical patient . Bailey & Love's Short Practice of Surgery ,

Jhanji S, Lee C, Watson D, Hinds CJ, Pearse RM ( 2008 ) . Tissue oxygenation and microvascular flow after major abdominal surgery . SHOCK . vol. 29 , 64 - 64 .

Frith D, Chesebro B, Patel N, Thiemermann C, Brohi K, Cohen M, Pearse R ( 2008 ) . Towards a mouse model for acute coagulopathy of trauma/shock . SHOCK . vol. 29 , 6 - 6 .

McGinley A, Pearse RM ( 2007 ) . DeVita MA, Hillman K, Bellomo R (Eds): Medical Emergency Teams: Implementation and Outcome Measurement,1st edition. New York: Springer . Critical Care vol. 11 , ( 2 )

Pearse RM, Young JD ( 2007 ) . Steroids to prevent postextubation laryngeal oedema . Lancet vol. 369 , ( 9567 ) 1060 - 1061 .

Belsey J, Pearse R, Cole J, Bennet D ( 2007 ) . An individual patient meta-analysis of clinical trials using dopexamine to increase oxygen delivery in high-risk surgical patients . Critical Care vol. 11 , ( Suppl 2 )

Maddison B, Best T, Wolff C, Jones P, Hinds C, Pearse R ( 2007 ) . Transpulmonary lithium indicator dilution: a new method of intrathoracic blood volume measurement . Critical Care vol. 11 , ( Suppl 2 )

Pearse RM, Dawson D, Fawcett J, Rhodes A, Grounds RM, Bennett D ( 2007 ) . The incidence of myocardial injury following post-operative Goal Directed Therapy . BMC Cardiovasc Disord vol. 7 ,

Maddison B, Best T, Pearse RM ( 2007 ) . Extravascular Lung Water Measurement . Intensive Care Medicine , Springer Nature

Pearse RM, Harrison DA, James P, Watson D, Hinds C, Rhodes A, Grounds RM, Bennett ED ( 2006 ) . Identification and characterisation of the high-risk surgical population in the United Kingdom . Crit Care vol. 10 , ( 3 )

Collinson PO, Wort S, Bruce H, Rhodes A, Pearse R, Bennett ED ( 2006 ) . Plasma DNA concentration as a predictor of mortality and sepsis in general intensive care patients . CLINICAL CHEMISTRY . vol. 52 , A12 - A12 .

Pearse RM, Hinds CJ ( 2006 ) . Should we use central venous saturation to guide management in high-risk surgical patients? . Crit Care vol. 10 , ( 6 )

Pearse R, Dawson D, Fawcett J, Rhodes A, Grounds RM, Bennett ED ( 2005 ) . Changes in central venous saturation after major surgery, and association with outcome . Critical Care vol. 9 , ( 6 )

Pearse R, Dawson D, Fawcett J, Rhodes A, Grounds RM, Bennett ED ( 2005 ) . Early goal-directed therapy after major surgery reduces complications and duration of hospital stay. A randomised, controlled trial [ISRCTN38797445] . Critical Care vol. 9 , ( 6 )

Bates CJ, Pearse R ( 2005 ) . Use of hydrogen peroxide vapour for environmental control during a Serratia outbreak in a neonatal intensive care unit . Journal of Hospital Infection vol. 61 , ( 4 ) 364 - 366 .

Pearse R, Dawson D, Fawcett J, Rhodes A, Grounds M, Bennnett D ( 2005 ) . Early goal directed therapy reduces morbidity and length of hospital stay following high-risk surgery . Critical Care vol. 9 , ( Suppl 1 )

Jin DK, Young LM, Vincent L, Gelbshtein U, Pekle K, Lam G, Shido K, Cho HJ et al. ( 2005 ) . Multimodular analysis of angiogenic biomarkers in the primary treatment of multiple myeloma: Correlative studies of the BiRD trial . BLOOD . vol. 106 , 972A - 972A .

Wort SJ, Rhodes A, Thomas H, Pearse R, Collinson P, Bennett ED ( 2005 ) . The role of plasma DNA concentration as a predictor of mortality and sepsis in critically ill patients . THORAX . vol. 60 , II116 - II116 .

Pearse RM, Rhodes A, Grounds R ( 2004 ) . Clinical review: How to optimize management of high-risk surgical patients . Critical Care vol. 8 , ( 6 )

Pearse RM ( 2004 ) . Equipment review . Critical Care vol. 8 , ( 3 ) 193 - 195 .

Pearse RM, Ikram K, Barry J ( 2004 ) . Equipment review: An appraisal of the LiDCO™plus method of measuring cardiac output . Critical Care vol. 8 , ( 3 )

Wort S, Rhodes A, Thomas H, Pearse R, Collinson P ( 2004 ) . Plasma DNA concentration as a predictor of mortality and sepsis in critically ill patients . Critical Care vol. 8 , ( Suppl 1 )

Pearse R, Dawson D, Fawcett J, Wort S, Rhodes A, Grounds R ( 2004 ) . The relationship between central venous saturation and outcome following high-risk surgery . Critical Care vol. 8 , ( Suppl 1 )

Pearse R, Wort S ( 2004 ) . Acute respiratory distress syndrome (ARDS) . Clinical Intensive Care vol. 15 , ( 1 ) 37 - 42 .

Pearse RM, Draper A, Grounds RM ( 2003 ) . Non-invasive ventilation to avoid tracheal intubation in a patient with Guillain-Barré syndrome . British Journal of Anaesthesia vol. 91 , ( 6 ) 913 - 916 .

R P, SJ W, M T, A R ( 2003 ) . Critical care clinical conundrums . Clinical Intensive Care vol. 14 , ( 3-4 ) 149 - 155 .

Pearse RM, Dawson D, Rhodes A, Grounds RM, Bennett ED ( 2003 ) . Low central venous saturation predicts post-operative mortality . INTENSIVE CARE MEDICINE . vol. 29 , S15 - S15 .

Dawson D, Pearse R, Rhodes A, Bennett D ( 2003 ) . Reliability of venous blood gas measurements in the recognition of the acutely ill patient . INTENSIVE CARE MEDICINE . vol. 29 , S178 - S178 .

Pearse RM, Dana EC, Lanigan CJ, Pook JAR ( 2002 ) . Organisational failures in urgent and emergency surgeryA potential peri‐operative risk factor . Anaesthesia vol. 56 , ( 7 ) 684 - 689 .

Pearse R, Rajakulendran Y ( 2001 ) . Pre‐operative fasting and administration of regular medications in adult patients presenting for elective surgery. Has the new evidence changed practice? . European Journal of Anaesthesiology vol. 16 , ( 8 ) 565 - 568 .

Pearse R, Rajakulendran Y ( 1999 ) . Pre-operative fasting and administration of regular medications in adult patients presenting for elective surgery. Has the new evidence changed practice? . European Journal of Anaesthesiology vol. 16 , ( 8 ) 565 - 568 .

Pearse RM, Mitra AV, Heymann TD ( 1999 ) . What the SHO really does . Clinical Medicine vol. 33 , ( 6 ) 553 - 556 .

Lee CN, Vasilakis C, Kearney D, Pearse R, Millard PH ( 1998 ) . An analysis of admission, discharge and bed occupancy of stroke patients aged 65 and over in English hospitals . Health Care Management Science vol. 1 , ( 2 ) 151 - 157 .

Cottee MA, Lee CN, Pearse R, MacKinnon A, Millard PH ( 1998 ) . The Value of Albert's Test and Line Bisection in Geriatric Patients . Age and Ageing vol. 27 , ( suppl_2 )

Kelly RI, Pearse R, Bull RH, Leveque J-L, de Rigal J, Mortimer PS ( 1995 ) . The effects of aging on the cutaneous microvasculature . Journal of the American Academy of Dermatology vol. 33 , ( 5 ) 749 - 756 .