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Publications:  Prof Costantino Pitzalis

Wei K, Korsunsky I, Marshall JL, Gao A, Watts GFM, Major T, Croft AP, Watts J et al.(2020). Notch signalling drives synovial fibroblast identity and arthritis pathology. Nature vol. 582, (7811) 259-264.
10.1038/s41586-020-2222-z
(2020). Increased plasma levels of Gas6 and its soluble tyrosine kinase receptors Mer and Axl are associated with immunological activity and severity of lupus nephritis. Clinical and experimental rheumatology
Rivellese F, Pontarini E, Pitzalis C(2020). Tertiary Lymphoid Organs in Rheumatoid Arthritis. Curr Top Microbiol Immunol
10.1007/82_2020_216
Svensson MND, Zoccheddu M, Yang S, Nygaard G, Secchi C, Doody KM, Slowikowski K, Mizoguchi F et al.(2020). Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal. Science Advances vol. 6, (26)
10.1126/sciadv.aba4353
Romão VC, Humby F, Kelly S, Di Cicco M, Mahto A, Lazarou I, Hands R, Rocher-Ros V et al.(2020). Treatment-resistant synovitis and radiographic progression are increased in elderly-onset rheumatoid arthritis patients: findings from a prospective observational longitudinal early arthritis cohort study. Semin Arthritis Rheum vol. 50, (4) 735-743.
10.1016/j.semarthrit.2020.03.018
Nerviani A, Di Cicco M, Mahto A, Lliso-Ribera G, Rivellese F, Thorborn G, Hands R, Bellan M et al.(2020). A Pauci-Immune Synovial Pathotype Predicts Inadequate Response to TNFα-Blockade in Rheumatoid Arthritis Patients. Frontiers in Immunology vol. 11,
10.3389/fimmu.2020.00845
Huizinga TWJ, Holers VM, Anolik J, Brenner MB, Buckley CD, Bykerk V, Connolly SE, Deane KD et al.(2020). Disruptive innovation in rheumatology: New networks of global public-private partnerships are needed to take advantage of scientific progress. Annals of the Rheumatic Diseases vol. 79, (5) 553-555.
10.1136/annrheumdis-2019-216846
Corsiero E, Carlotti E, Jagemann L, Perretti M, Pitzalis C, Bombardieri M(2020). H and L chain affinity maturation and/or Fab N-glycosylation influence immunoreactivity toward neutrophil extracellular trap antigens in rheumatoid arthritis synovial b cell clones. Journal of Immunology vol. 204, (9) 2374-2379.
10.4049/jimmunol.1901457
Lucchesi D, Coleby R, Pontarini E, Prediletto E, Rivellese F, Hill DG, Derrac Soria A, Jones SA et al.(2020). Impaired IL-27 Mediated Control of CD4+ T Cell Function Impacts on Ectopic Lymphoid Structure Formation in Patients with Sjögren's Syndrome. Arthritis Rheumatol
10.1002/art.41289
Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A et al. (2020). B CELL-RICH SYNOVITIS IN EARLY AND ESTABLISHED RHEUMATOID ARTHRITIS. RHEUMATOLOGY. vol. 59,
Nerviani A, Lliso-Ribera G, Boutet M-A, Goldmann K, Rivellese F, Kelly S, Bombardieri M, Lewis M et al. (2020). HISTOLOGICAL AND MOLECULAR FEATURES OF THE DISEASED SYNOVIUM IN EARLY UNTREATED PSA IN COMPARISON WITH RA. RHEUMATOLOGY. vol. 59,
Lucchesi D, Coleby R, Pontarini E, Prediletto E, Rivellese F, Hill D, Soria AD, Jones S et al. (2020). IL-27 REGULATES THE MAGNITUDE OF ECTOPIC GERMINAL CENTRES IN EXPERIMENTAL SIALADENITIS BUT FAILS TO MODULATE IL-17 AND IFNG PRODUCTION IN CD4 T CELLS FROM PATIENTS WITH SJOGREN'S SYNDROME. RHEUMATOLOGY. vol. 59,
Sciacca E, Alaimo S, Pulvirenti A, Latora V, Humby F, Ferro A, Lewis MJ, Pitzalis C (2020). MICRO-RNA ENRICHED PATHWAY IMPACT ANALYSIS APPLIED TO SYNOVIAL RNA-SEQ IN EARLY RHEUMATOID ARTHRITIS IDENTIFIES RESPONSE PREDICTION PATHWAYS. RHEUMATOLOGY. vol. 59,
MacBrayne ACB, Pott J, Petrovic V, Pitzalis C, Humby F (2020). PRELIMINARY RESULTS: DRIVING IMPROVEMENTS IN DISEASE OUTCOMES FOR RHEUMATOID ARTHRITIS PATIENTS USING REMOTE DISEASE ACTIVITY MONITORING VIA SMARTPHONE APP. RHEUMATOLOGY. vol. 59,
Humby FC, Lewis M, Durez P, Buch MH, Bombardieri M, Rizvi H, Rivellese F, Fossati L et al. (2020). RANDOMISED, OPEN LABELLED CLINICAL TRIAL TO INVESTIGATE SYNOVIAL MECHANISMS DETERMINING RESPONSE: RESISTANCE TO RITUXIMAB VERSUS TOCILIZUMAB IN RA PATIENTS FAILING TNF INHIBITOR THERAPY. RHEUMATOLOGY. vol. 59, 3-+.
Muñoz-Atienza E, Flak MB, Sirr J, Paramonov NA, Aduse-Opoku J, Pitzalis C, Curtis MA(2020). The P. gingivalis Autocitrullinome Is Not a Target for ACPA in Early Rheumatoid Arthritis. Journal of Dental Research vol. 99, (4) 456-462.
10.1177/0022034519898144
Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A et al.(2020). B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure. Arthritis and Rheumatology
10.1002/art.41184
https://qmro.qmul.ac.uk/xmlui/handle/123456789/63258
Pernicova I, Kelly S, Ajodha S, Sahdev A, Bestwick JP, Gabrovska P, Akanle O, Ajjan R et al.(2020). Metformin to reduce metabolic complications and inflammation in patients on systemic glucocorticoid therapy: a randomised, double-blind, placebo-controlled, proof-of-concept, phase 2 trial. Lancet Diabetes and Endocrinology
10.1016/S2213-8587(20)30021-8
https://qmro.qmul.ac.uk/xmlui/handle/123456789/63260
John CR, Watson D, Barnes MR, Pitzalis C, Lewis MJ(2020). Spectrum: Fast density-aware spectral clustering for single and multi-omic data. Bioinformatics vol. 36, (4) 1159-1166.
10.1093/bioinformatics/btz704
https://qmro.qmul.ac.uk/xmlui/handle/123456789/64588
John CR, Watson D, Russ D, Goldmann K, Ehrenstein M, Pitzalis C, Lewis M, Barnes M(2020). M3C: Monte Carlo reference-based consensus clustering. Scientific Reports vol. 10, (1)
10.1038/s41598-020-58766-1
https://qmro.qmul.ac.uk/xmlui/handle/123456789/63004
Pagani S, Bellan M, Mauro D, Castello LM, Avanzi GC, Lewis MJ, Sainaghi PP, Pitzalis C et al.(2020). New Insights into the Role of Tyro3, Axl, and Mer Receptors in Rheumatoid Arthritis. Disease Markers vol. 2020, Article 1614627,
10.1155/2020/1614627
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62984
Alivernini S, MacDonald L, Elmesmari A, Finlay S, Tolusso B, Gigante MR, Petricca L, Di Mario C et al.(2020). Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis. Nature Medicine
10.1038/s41591-020-0939-8
Lliso-Ribera G, Humby F, Lewis M, Nerviani A, Mauro D, Rivellese F, Kelly S, Hands R et al.(2019). Synovial tissue signatures enhance clinical classification and prognostic/treatment response algorithms in early inflammatory arthritis and predict requirement for subsequent biological therapy: Results from the pathobiology of early arthritis cohort (PEAC). Annals of the Rheumatic Diseases vol. 78, (12) 1642-1652.
10.1136/annrheumdis-2019-215751
https://qmro.qmul.ac.uk/xmlui/handle/123456789/63523
Pucino V, Certo M, Bulusu V, Cucchi D, Goldmann K, Pontarini E, Haas R, Smith J et al.(2019). Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring. Cell Metabolism
10.1016/j.cmet.2019.10.004
https://qmro.qmul.ac.uk/xmlui/handle/123456789/61253
Rodríguez-Ubreva J, De La Calle-Fabregat C, Li T, Ciudad L, Ballestar ML, Català-Moll F, Morante-Palacios O, Garcia-Gomez A et al.(2019). Inflammatory cytokines shape a changing DNA methylome in monocytes mirroring disease activity in rheumatoid arthritis. Annals of the Rheumatic Diseases vol. 78, (11) 1505-1516.
10.1136/annrheumdis-2019-215355
Humby F, Buch MH, Durez P, Lewis M, Bombardieri M, Rizvi H, Kelly S, Fosatti L et al. (2019). A Randomised, Open Labelled Clinical Trial to Investigate Synovial Mechanisms Determining Response - Resistance to Rituximab versus Tocilizumab in Rheumatoid Arthritis Patients Failing TNF Inhibitor Therapy. ARTHRITIS & RHEUMATOLOGY. vol. 71,
Corsiero E, Jagemann L, Perretti M, Pitzalis C, Bombardieri M (2019). Characterization of calreticulin, a stromal-derived autoantigens, recognized by RA synovial recombinant monoclonal antibodies. EUROPEAN JOURNAL OF IMMUNOLOGY. vol. 49, 773-774.
Pucino V, Certo M, Bulusu V, Goldmann K, Cucchi D, Haas R, Smith J, Blighe K et al. (2019). Lactate influx into human CD4+T-cells, via SLC5A12, causes STAT3-and fatty acid synthesis-mediated IL17 expression and tissue retention. EUROPEAN JOURNAL OF IMMUNOLOGY. vol. 49, 1276-1277.
Rivellese F, Lliso-Ribera G, Nerviani A, Humby F, Pitzalis C (2019). Persistence of B Cell-rich Synovitis Following Conventional Synthetic Disease Modifying Anti-Rheumatic Drug Treatment in Early Rheumatoid Arthritis Is Associated with Radiographic Progression Independently of Clinical Response. ARTHRITIS & RHEUMATOLOGY. vol. 71,
Tarn JR, Howard-Tripp N, Lendrem DW, Mariette X, Saraux A, Devauchelle-Pensec V, Seror R, Skelton AJ et al.(2019). Symptom-based stratification of patients with primary Sjögren's syndrome: multi-dimensional characterisation of international observational cohorts and reanalyses of randomised clinical trials. The Lancet Rheumatology vol. 1, (2) e85-e94.
10.1016/S2665-9913(19)30042-6
Prediletto E, Pontarini E, Lucchesi D, Corsiero E, Pratesi F, Migliorini P, Pitzalis C, Bombardieri M (2019). Synovial fluid fibroblast-like synoviocytes enhance long-term survival of EBV infected memory B cells in rheumatoid arthritis. EUROPEAN JOURNAL OF IMMUNOLOGY. vol. 49, 791-791.
Mauro D, Macaluso F, Nerviani A, Boutet M-A, Rizzo A, Alessandro R, Guggino G, Pitzalis C et al. (2019). The Deubiquitinase TRABID Is a Potential Therapeutic Target in Spondyloarthritis. ARTHRITIS & RHEUMATOLOGY. vol. 71,
Mattiola I, Tomay F, De Pizzol M, Silva-Gomes R, Savino B, Gulic T, Doni A, Lonardi S et al. (2019). The macrophage tetraspan MS4A4A enhances Dectin-1-dependent NK cell-mediated resistance to metastasis. EUROPEAN JOURNAL OF IMMUNOLOGY. vol. 49, 1517-1518.
Boutet M-A, Nerviani A, Lliso-Ribera G, Lucchesi D, Prediletto E, Ghirardi GM, Goldmann K, Lewis M et al.(2019). Interleukin-36 family dysregulation drives joint inflammation and therapy response in psoriatic arthritis. Rheumatology
10.1093/rheumatology/kez358
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62220
Colombo F, Durigutto P, De Maso L, Biffi S, Belmonte B, Tripodo C, Oliva R, Bardini P et al.(2019). Targeting CD34<sup>+</sup> cells of the inflamed synovial endothelium by guided nanoparticles for the treatment of rheumatoid arthritis. Journal of Autoimmunity vol. 103,
10.1016/j.jaut.2019.05.016
https://qmro.qmul.ac.uk/xmlui/handle/123456789/61552
Mattiola I, Tomay F, De Pizzol M, Silva-Gomes R, Savino B, Gulic T, Doni A, Lonardi S et al. (2019). The macrophage tetraspan MS4A4A enhances Dectin-1-dependent NK cell-mediated resistance to metastasis. EUROPEAN JOURNAL OF IMMUNOLOGY. vol. 49, 17-18.
Lewis MJ, Barnes MR, Blighe K, Goldmann K, Rana S, Hackney JA, Ramamoorthi N, John CR et al.(2019). Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes. Cell Reports vol. 28, 2455-2470.
10.1016/j.celrep.2019.07.091
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59563
Romão VC, Polido-Pereira J, Barros R, Luís R, Vidal B, Vieira-Sousa E, Vitorino E, Humby F et al.(2019). Efficacy, safety and sample quality of ultrasound-guided synovial needle biopsy in clinical practice and research: a prospective observational study. Arthritis Care and Research
10.1002/acr.24050
https://qmro.qmul.ac.uk/xmlui/handle/123456789/63102
Spiliopoulou A, Colombo M, Plant D, Nair N, Cui J, Coenen MJH, Ikari K, Yamanaka H et al.(2019). Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for CD40 and CD39. Annals of the Rheumatic Diseases vol. 78, (8) 1055-1061.
10.1136/annrheumdis-2018-214877
Mattiola I, Tomay F, De Pizzol M, Silva-Gomes R, Savino B, Gulic T, Doni A, Lonardi S et al.(2019). The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis. Nature Immunology vol. 20, (8) 1012-1022.
10.1038/s41590-019-0417-y
https://qmro.qmul.ac.uk/xmlui/handle/123456789/58603
Humby F, Lewis M, Townsend MJ, Pitzalis C(2019). Response to 'Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients' by Humby et al. Ann Rheum Dis
10.1136/annrheumdis-2019-215903
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59783
Flak MB, Colas RA, Muñoz-Atienza E, Curtis MA, Dalli J, Pitzalis C(2019). Inflammatory arthritis disrupts gut resolution mechanisms, promoting barrier breakdown by Porphyromonas gingivalis. JCI Insight vol. 4, (13)
10.1172/jci.insight.125191
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59622
El Shikh MEM, El Sayed R, Nerviani A, Goldmann K, John CR, Hands R, Fossati-Jimack L, Lewis MJ et al.(2019). Extracellular traps and PAD4 released by macrophages induce citrullination and auto-antibody production in autoimmune arthritis. Journal of Autoimmunity
10.1016/j.jaut.2019.06.008
https://qmro.qmul.ac.uk/xmlui/handle/123456789/58983
Zhang F, Wei K, Slowikowski K, Fonseka CY, Rao DA, Kelly S, Goodman SM, Tabechian D et al.(2019). Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry. Nature Immunology vol. 20, (7) 928-942.
10.1038/s41590-019-0378-1
Pontarini E, Brown WM, Croia C, Lucchesi D, Rivellese F, Fossati-Jimack L, Ruscitti P, Prediletto E et al. (2019). A UNIQUE IL-21 SIGNATURE CHARACTERIZES LESIONAL AND CIRCULATING T-FOLLICULAR HELPER CELLS IN SJOGREN'S SYNDROME PATIENTS WITH ECTOPIC GERMINAL CENTRES AND MALT LYMPHOMA. ANNALS OF THE RHEUMATIC DISEASES. vol. 78, 221-221.
10.1136/annrheumdis-2019-eular.7644
https://qmro.qmul.ac.uk/xmlui/handle/123456789/65013
Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Ribera GL, Nerviani A et al. (2019). B CELL SYNOVITIS AND CLINICAL PHENOTYPES IN RHEUMATOID ARTHRITIS AT DIFFERENT DISEASE STAGES. ANNALS OF THE RHEUMATIC DISEASES. vol. 78, 296-297.
10.1136/annrheumdis-2019-eular.1284
Ribera GL, Humby F, Nerviani A, Lewis M, Kelly S, Bombardieri M, Goldmann K, Hands R et al. (2019). BASELINE CELLULAR AND MOLECULAR CHARACTERISTICS OF SYNOVIAL TISSUE AND RELATION WITH TNFI RESPONSE. RESULTS FROM THE PATHOBIOLOGY OF THE EARLY ARTHRITIS COHORT (PEAC). ANNALS OF THE RHEUMATIC DISEASES. vol. 78, 134-134.
10.1136/annrheumdis-2019-eular.2617
Nerviani A, Humby F, Ribera GL, Rivellese F, Kelly S, Hands R, Pitzalis C (2019). DEFINING A LEARNING CURVE FOR CLINICIANS PERFORMING ULTRASOUND-GUIDED DEFINING A LEARNING CURVE FOR CLINICIANS PERFORMING ULTRASOUND-GUIDED NEEDLE SYNOVIAL BIOPSIES: A RETROSPECTIVE ANALYSIS OF THE EXPERIENCE AT THE EXPERIMENTAL MEDICINE AND RHEUMATOLOGY, QUEEN MARY UNIVERSITY OF LONDON. ANNALS OF THE RHEUMATIC DISEASES. vol. 78, 317-317.
10.1136/annrheumdis-2019-eular.7302
Lucchesi D, Coleby R, Pontarini E, Prediletto E, Hill D, Soria AD, Rivellese F, Pitzalis C et al. (2019). DENDRITIC CELL-DERIVED IL-27 REGULATES THE MAGNITUDE OF INDUCIBLE ECTOPIC GERMINAL CENTRES BUT FAILS TO DOWNMODULATE IL-17 PRODUCTION IN CD4 T CELLS FROM PATIENTS WITH SJOGREN'S SYNDROME. ANNALS OF THE RHEUMATIC DISEASES. vol. 78, 220-220.
10.1136/annrheumdis-2019-eular.5889
Nerviani A, Ribera GL, Boutet MA, Goldmann K, Kelly S, Bombardieri M, Lewis M, Humby F et al. (2019). HISTOLOGICAL AND MOLECULAR PORTRAIT OF THE SYNOVIAL TISSUE IN EARLY TREATMENT-NAIVE PSORIATIC ARTHRITIS IN COMPARISON WITH RHEUMATOID ARTHRITIS. ANNALS OF THE RHEUMATIC DISEASES. vol. 78, 130-131.
10.1136/annrheumdis-2019-eular.3634
Mauro D, Rivellese F, Manou-Stathopoulou S, Goldmann K, Pyne D, Ciccia F, Pitzalis C, Lewis M (2019). THE EFFECT OF DIMETHYL FUMARATE ON PLASMABLAST DIFFERENTIATION TRANSCRIPTIONAL PROGRAMMES IN SYSTEMIC LUPUS ERYTHEMATOSUS. ANNALS OF THE RHEUMATIC DISEASES. vol. 78, 1077-1077.
10.1136/annrheumdis-2019-eular.7792
Rivellese F, Manou-Stathopoulou S, Mauro D, Pontarini E, Lucchesi D, Congia M, Schafer P, Sutcliffe N et al. (2019). THE TRANSCRIPTION FACTORS IKAROS (IKZF1) AND AIOLOS (IKZF3) ARE EXPRESSED IN THE SALIVARY GLANDS OF SJOGREN'S SYNDROME PATIENTS WITH LYMPHOID AGGREGATES AND MODULATE B CELL ACTIVATION IN VITRO. ANNALS OF THE RHEUMATIC DISEASES. vol. 78, 394-395.
10.1136/annrheumdis-2019-eular.7333
Manou-Stathopoulou S, Rivellese F, Mauro D, Goldmann K, Pyne D, Schafer P, Bombardieri M, Pitzalis C et al. (2019). THE TRANSCRIPTION FACTORS IKZF1 AND IKZF3 CONTROL B CELL ACTIVATION AND DIFFERENTIATION IN SYSTEMIC LUPUS ERYTHEMATOSUS. ANNALS OF THE RHEUMATIC DISEASES. vol. 78, 1548-1548.
10.1136/annrheumdis-2019-eular.6343
Purkayastha N, Ismail S, Taylor PC, Pitzalis C, Kelly S (2019). ULTRASOUND POWER DOPPLER SEMI-QUANTITATIVE SCORING, IS IT TIME WE MOVED TO A RED PIXEL DENSITY ALGORITHMIC PROGRAM TO DETERMINE TRUE TREATMENT RESPONSE?. ANNALS OF THE RHEUMATIC DISEASES. vol. 78, 258-259.
10.1136/annrheumdis-2019-eular.1527
Bottini A, Wu DJ, Ai R, Le Roux M, Bartok B, Bombardieri M, Doody KM, Zhang V et al.(2019). PTPN14 phosphatase and YAP promote TGFβ signalling in rheumatoid synoviocytes. Annals of the Rheumatic Diseases vol. 78, (5) 600-609.
10.1136/annrheumdis-2018-213799
https://qmro.qmul.ac.uk/xmlui/handle/123456789/56182
Rivellese F, Rossi FW, Galdiero MR, Pitzalis C, de Paulis A(2019). Mast cells in early rheumatoid arthritis. International Journal of Molecular Sciences vol. 20, (8)
10.3390/ijms20082040
https://qmro.qmul.ac.uk/xmlui/handle/123456789/58683
Twohig JP, Cardus Figueras A, Andrews R, Wiede F, Cossins BC, Derrac Soria A, Lewis MJ, Townsend MJ et al.(2019). Activation of naïve CD4 <sup>+</sup> T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4 <sup>+</sup> T cells. Nature Immunology vol. 20, (4) 458-470.
10.1038/s41590-019-0350-0
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59555
Hackett KL, Davies K, Tarn J, Bragg R, Hargreaves B, Miyamoto S, McMeekin P, Mitchell S et al.(2019). Pain and depression are associated with both physical and mental fatigue independently of comorbidities and medications in primary Sjögren's syndrome. RMD Open vol. 5, (1)
10.1136/rmdopen-2018-000885
https://qmro.qmul.ac.uk/xmlui/handle/123456789/64687
Fisher BA, Emery P, Pitzalis C, Bombardieri M, Bowman SJ(2019). Response to: Can ultrasound of the major salivary glands assess histopathological changes induced by treatment with rituximab in primary Sjögren's syndrome?. Ann Rheum Dis vol. 78, (4)
10.1136/annrheumdis-2018-213340
HUMBY F(2019). Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients. Annals of the Rheumatic Diseases
10.1136/annrheumdis-2018-214539
https://qmro.qmul.ac.uk/xmlui/handle/123456789/58941
Boutet M-A, Nerviani A, Pitzalis C(2019). IL-36, IL-37, and IL-38 Cytokines in Skin and Joint Inflammation: A Comprehensive Review of Their Therapeutic Potential. Int J Mol Sci vol. 20, (6)
10.3390/ijms20061257
https://qmro.qmul.ac.uk/xmlui/handle/123456789/58681
Boutet M-A, Nerviani A, Lliso-Ribera G, Goldmann K, Lewis M, Pitzalis C (2019). IL-36 AXIS IS AN EMERGING THERAPEUTIC TARGET IN PSORIATIC ARTHRITIS SYNOVIAL TISSUE. ANNALS OF THE RHEUMATIC DISEASES. vol. 78, A56-A56.
10.1136/annrheumdis-2018-EWRR2019.113
Hensor EMA, McKeigue P, Ling SF, Colombo M, Barrett JH, Nam JL, Freeston J, Buch MH et al.(2019). Validity of a two-component imaging-derived disease activity score for improved assessment of synovitis in early rheumatoid arthritis. Rheumatology (Oxford)
10.1093/rheumatology/kez049
https://qmro.qmul.ac.uk/xmlui/handle/123456789/56623
PITZALIS C, CORSIERO E, DELVECCHIO F, BOMBARDIERI M(2019). B cells in the formation of Tertiary Lymphoid Organs in autoimmunity, transplantation and tumorigenesis. Current Opinion in Immunology vol. 57, 46-52.
10.1016/j.coi.2019.01.004
https://qmro.qmul.ac.uk/xmlui/handle/123456789/56179
Dorris ER, Tazzyman SJ, Moylett J, Ramamoorthi N, Hackney J, Townsend M, Muthana M, Lewis MJ et al.(2019). The autoimmune susceptibility gene C5orf30 regulates macrophage-mediated resolution of inflammation. Journal of Immunology vol. 202, (4) 1069-1078.
10.4049/jimmunol.1801155
https://qmro.qmul.ac.uk/xmlui/handle/123456789/55324
Cope AP, Barnes MR, Belson A, Binks M, Brockbank S, Bonachela-Capdevila F, Carini C, Fisher BA et al.(2018). The RA-MAP Consortium: a working model for academia-industry collaboration. Nat Rev Rheumatol vol. 14, (1) 53-60.
10.1038/nrrheum.2017.200
https://qmro.qmul.ac.uk/xmlui/handle/123456789/35063
Rivellese F, Mauro D, Nerviani A, Pagani S, Fossati-Jimack L, Messemaker T, Kurreeman FAS, Toes REM et al.(2018). Mast cells in early rheumatoid arthritis associate with disease severity and support B cell autoantibody production. Annals of the Rheumatic Diseases vol. 77, (12) 1773-1781.
10.1136/annrheumdis-2018-213418
https://qmro.qmul.ac.uk/xmlui/handle/123456789/44263
Cherlin S, Plant D, Taylor JC, Colombo M, Spiliopoulou A, Tzanis E, Morgan AW, Barnes MR et al.(2018). Prediction of treatment response in rheumatoid arthritis patients using genome-wide SNP data. Genetic Epidemiology vol. 42, (8) 754-771.
10.1002/gepi.22159
Just SA, Humby F, Lindegaard H, De Bellefon LM, Durez P, Vieira-Sousa E, Teixeira R, Stoenoiu M et al.(2018). Patient-reported outcomes and safety in patients undergoing synovial biopsy: Comparison of ultrasound-guided needle biopsy, ultrasound-guided portal and forceps and arthroscopic-guided synovial biopsy techniques in five centres across Europe. RMD Open vol. 4, (2)
10.1136/rmdopen-2018-000799
Cecchinato V, D'Agostino G, Raeli L, Nerviani A, Schiraldi M, Danelon G, Manzo A, Thelen M et al.(2018). Redox-Mediated Mechanisms Fuel Monocyte Responses to CXCL12/HMGB1 in Active Rheumatoid Arthritis. Frontiers in Immunology vol. 9, 2118-2118.
10.3389/fimmu.2018.02118
Nerviani A, Humby F, Ribera GL, Tan WS, Boutet MA, Goldmann K, Bene F, Hands R et al. (2018). Comparative Histologic and Molecular Analysis of Synovial Tissue in Early Treatment-Naive Psoriatic and Rheumatoid Arthritis. ARTHRITIS & RHEUMATOLOGY. vol. 70,
Rivellese F, Mauro D, Congia M, Pontarini E, Schafer P, Bombardieri M, Pitzalis C, Lewis MJ (2018). Expression and Functions of the Transcription Factors Ikaros and Aiolos in Sjogren's Syndrome and Systemic Lupus Erythematosus. ARTHRITIS & RHEUMATOLOGY. vol. 70,
Massey J, Plant D, Hyrich K, Morgan AW, Wilson AG, Spiliopoulou A, Colombo M, McKeigue P et al.(2018). Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis. Pharmacogenomics J vol. 18, (5) 657-664.
10.1038/s41397-018-0040-6
Ruiz-Romero C, Picchi F, Fernandez P, Gonzalez L, Hands R, Calamia V, Camacho M, Bessant C et al. (2018). Identification of a Panel of Circulating Proteins Associated to Synovial Pathotypes in Early Rheumatoid Arthritis Patients. ARTHRITIS & RHEUMATOLOGY. vol. 70,
Ruiz-Romero C, Picchi F, Gonzalez L, Hands R, Calamia V, Fernandez P, Camacho M, Paz R et al. (2018). Identification of a Protein Profile Useful to Predict Response to Methotrexate in Early Rheumatoid Arthritis Patients. ARTHRITIS & RHEUMATOLOGY. vol. 70,
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Lliso-Ribera G, Humby F, Kelly S, Bombardieri M, Lewis M, Hands R, Rocher V, Bene F et al. (2017). SYNOVIAL PATHOBIOLOGY CORRELATES WITH DIAGNOSTIC SUBGROUPS IN EARLY INFLAMMATORY ARTHRITIS: RESULTS FROM THE PATHOBIOLOGY OF EARLY ARTHRITIS COHORT (PEAC). ANNALS OF THE RHEUMATIC DISEASES. vol. 76, 511-511.
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Mandelin AM, Homan P, Cuda CM, Dominguez ST, Bridges SL, Bathon JM, Atkinson J, Fox D et al. (2017). THE PROMISE OF ULTRASOUND GUIDED MINIMALLY INVASIVE SYNOVIAL BIOPSIES IN THE UNITED STATES. ANNALS OF THE RHEUMATIC DISEASES. vol. 76, 1125-1125.
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Humby FC, Al Balushi F, Lliso G, Cauli A, Pitzalis C(2017). Can Synovial Pathobiology Integrate with Current Clinical and Imaging Prediction Models to Achieve Personalized Health Care in Rheumatoid Arthritis?. Front Med (Lausanne) vol. 4, 41-41.
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Thorup A-S, Eldridge SE, Caxaria S, Nalesso G, Thomas BL, Pitzalis C, Luyten F, Dell'Accio F (2017). A POTENCY ASSAY FOR ASSESSING THE CHONDROGENIC EFFICIENCY OF BIOACTIVE MOLECULES IN HUMAN CARTILAGE IN VIVO. OSTEOARTHRITIS AND CARTILAGE. vol. 25, S273-S273.
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Eldridge SE, Thomas BL, Shanmuganathan K, Strachan D, Ali A, Thorup A-S, Caxaria S, Nalesso G et al. (2017). AGRIN INHIBITS CANONICAL WNT SIGNALLING THROUGH LRP4. OSTEOARTHRITIS AND CARTILAGE. vol. 25, S165-S165.
10.1016/j.joca.2017.02.281
Kaneva MK, Greco KV, Headland SE, Montero-Melendez T, Mori P, Greenslade K, Pitzalis C, Moore A et al.(2017). Identification of novel chondroprotective mediators in resolving inflammatory exudates. Journal of Immunology vol. 198, (7) 2876-2885.
10.4049/jimmunol.1601111
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Caxaria S, Sherwood J, Roeder E, Luyten F, Pitzalis C, Dell'Accio F (2017). THE ROLE OF CXCL6 IN CARTILAGE DEVELOPMENT AND HOMEOSTASIS. OSTEOARTHRITIS AND CARTILAGE. vol. 25, S301-S301.
10.1016/j.joca.2017.02.507
Thomas BL, Nalesso G, Eldridge SE, Pitzalis C, Dell'accio F (2017). WNT16 IS UP-REGULATED IN THE JOINT FOLLOWING INFLAMMATION. OSTEOARTHRITIS AND CARTILAGE. vol. 25, S156-S156.
10.1016/j.joca.2017.02.264
Bowman SJ, Everett CC, O'Dwyer JL, Emery P, Pitzalis C, Ng W-F, Pease CT, Price EJ et al.(2017). Randomized Controlled Trial of Rituximab and cost-effectiveness analysis in treating fatigue and oral dryness in primary Sjogren's Syndrome. Arthritis Rheumatol
10.1002/art.40093
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Lucchesi D, Pontarini E, Pitzalis C, Mavilio D, Bombardieri M (2017). MYELOID CELLS DRIVE EARLY INFLAMMATION AND ORCHESTRATE SALIVARY GLANDS TERTIARY LYMPHOID STRUCTURES FORMATION IN A MODEL OF INDUCIBLE SIALADENITIS. ANNALS OF THE RHEUMATIC DISEASES. Conference: EWRR (Athens) from: 02/03/2017 to: 04/03/2017, vol. 76, A4-A4.
10.1136/annrheumdis-2016-211048.9
Corsiero E, Jagemann L, Prediletto E, Pitzalis C, Bombardieri M (2017). RA SYNOVIAL RECOMBINANT MONOCLONAL ANTIBODIES FROM SINGLE B CELLS TARGET CITRULLINATED CALRETICULIN. ANNALS OF THE RHEUMATIC DISEASES. vol. 76, A89-A90.
10.1136/annrheumdis-2016-211055.34
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Bombardieri M, Lewis M, Pitzalis C(2017). Ectopic lymphoid neogenesis in rheumatic autoimmune diseases. Nature Reviews Rheumatology
10.1038/nrrheum.2016.217
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Pucino V, Bombardieri M, Pitzalis C, Mauro C(2017). Lactate at the crossroads of metabolism, inflammation, and autoimmunity. European Journal of Immunology vol. 47, (1) 14-21.
10.1002/eji.201646477
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Taylor JC, Verstappen S, Wang J, Bongartz T, Scott I, Emery P, Pitzalis C, Barton A et al. (2016). Genome-Wide Meta-Analysis of Response to Methotrexate in Rheumatoid Arthritis Patients on behalf of the MATURA Consortium. GENETIC EPIDEMIOLOGY. vol. 40, 666-667.
Corsiero E, Nerviani A, Bombardieri M, Pitzalis C(2016). Ectopic Lymphoid Structures: Powerhouse of Autoimmunity. Front Immunol vol. 7, Article 00430, 430-430.
10.3389/fimmu.2016.00430
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Tan WSG, Kelly S, Pitzalis C(2016). Targeted therapies: what they teach us about the pathogenesis of psoriasis and psoriatic arthritis. Expert Rev Clin Immunol vol. 13, (3) 207-222.
10.1080/1744666X.2017.1241710
Guo Y, Walsh A, Fearon U, Smith MD, Wechalekar MD, Yin X, Cole S, Orr C et al. (2016). Gene Enrichment Analysis Identifies Active CD40-CD40L Signaling in Early and Established Rheumatoid Arthritis. ARTHRITIS & RHEUMATOLOGY. vol. 68,
Rivellese F, Humby F, Kelly S, de Paulis A, Marone G, Pitzalis C (2016). Synovial Mast Cells Associate with High Disease Activity and Predict Radiographic Progression at 12 Months in Patients with Early Rheumatoid Arthritis. ARTHRITIS & RHEUMATOLOGY. vol. 68,
Hensor EMA, McKeigue P, Conaghan PG, Buch MH, Barrett JH, Nam JL, Colombo M, Spiliopoulou A et al. (2016). Validity of a 2-Component Disease Activity Score for Accurate Assessment of Synovitis in Rheumatoid Arthritis. ARTHRITIS & RHEUMATOLOGY. vol. 68,
Jones GW, Bombardieri M, Greenhill CJ, McLeod L, Nerviani A, Rocher-Ros V, Cardus A, Williams AS et al. (2016). Interleukin-27 inhibits synovial lymphoid neogenesis in inflammatory arthritis. EUROPEAN JOURNAL OF IMMUNOLOGY. vol. 46, 1024-1024.
Murray-Brown W, Carlotti E, Floyd J, Sutcliffe N, Tappuni A, Vartoukian S, Fortune F, Mehr R et al. (2016). Next-generation sequencing demonstrates dynamic recirculation of B cell clones in ectopic lymphoid structures of Sjogren's syndrome. EUROPEAN JOURNAL OF IMMUNOLOGY. Conference: European League Against Rheumatism vol. 46, 939-940.
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Corsiero E, Carlotti E, Prediletto E, Jagemann L, Pitzalis C, Bombardieri M (2016). The role of somatic hypermutation and N-glycosylation in the anti-NET immunoreactivity of RA synovial monoclonal antibodies. EUROPEAN JOURNAL OF IMMUNOLOGY. vol. 46, 116-117.
Howard Tripp N, Tarn J, Natasari A, Gillespie C, Mitchell S, Hackett KL, Bowman SJ, Price E et al.(2016). Fatigue in primary Sjögren's syndrome is associated with lower levels of proinflammatory cytokines. RMD Open vol. 2, (2) e000282-e000282.
10.1136/rmdopen-2016-000282
Astorri E, Sutcliffe N, Richards PS, Suchak K, Pitzalis C, Bombardieri M, Tappuni AR(2016). Ultrasound of the salivary glands is a strong predictor of labial gland biopsy histopathology in patients with sicca symptoms. Journal of Oral Pathology and Medicine vol. 45, (6) 450-454.
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Astorri E, Lucchesi D, Pitzalis C, Bombardieri M(2016). Spontaneous and Inducible Animal Models of Sjögren's Syndrome. Sjogren's Syndrome: Novel Insights in Pathogenic, Clinical and Therapeutic Aspects,
Nerviani A, DiCicco M, Humby F, Kelly S, Zou L, Lewis M, Hands R, Rocher V et al. (2016). A BASELINE PREDICTION MODEL FOR RESPONSE TO CERTOLIZUMAB-PEGOL: ROLE OF SYNOVIAL HISTOPATHOLOGY. ANNALS OF THE RHEUMATIC DISEASES. vol. 75, 485-486.
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Eldridge S, Nalesso G, Ismail H, Vicente-Greco K, Kabouridis P, Ramachandran M, Niemeier A, Herz J et al.(2016). Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo. Annals of the Rheumatic Diseases vol. 75, (6) 1228-1235.
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Mauro D, Lewis MJ, Pullabhatla V, Vyse S, Simpson M, Cunninghame-Graham D, Syvanen AC, Pitzalis C et al. (2016). C1QTNF4 MUTATION IDENTIFIED BY EXOME SEQUENCING IS ASSOCIATED WITH SYSTEMIC LUPUS ERYTHEMATOSUS AND DYSREGULATION OF TNF-INDUCED APOPTOSIS. ANNALS OF THE RHEUMATIC DISEASES. Conference: Annual European Congress of Rheumatology EULAR 2016 vol. 75, 145-154.
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Nerviani A, Tan WS, Mahto A, Di Cicco M, Lazarou I, Ng N, Purkayastha N, Bellan M et al. (2016). HISTOPATHOLOGY OF TREATMENT-NAIVE PSORIATIC SYNOVITIS: A COMPARISON WITH EARLY RHEUMATOID ARTHRITIS. ANNALS OF THE RHEUMATIC DISEASES. vol. 75, 595-596.
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Genovese M, Fleischmann R, Furst D, Janssen N, Carter J, Dasgupta B, Pitzalis C, Vasyutin I et al. (2016). IMPROVEMENTS IN PATIENT-REPORTED OUTCOMES WITH OLOKIZUMAB TREATMENT IN PATIENTS WITH ACTIVE, MODERATE TO SEVERE RHEUMATOID ARTHRITIS WHO HAD FAILED PREVIOUS ANTI-TNF THERAPY: RESULTS FROM THE RA0056 DOUBLE-BLIND, RANDOMIZED CONTROLLED STUDY, AND RA0057, ITS OPEN-LABEL EXTENSION. ANNALS OF THE RHEUMATIC DISEASES. vol. 75, 718-719.
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Mahto A, Humby F, Gregoriadou S, Ng N, Blighe K, Zou L, Lewis M, Bombardieri M et al. (2016). SYNOVIAL B-CELL GENE SIGNATURE PREDICTS RESPONSE TO RITUXIMAB THERAPY. ANNALS OF THE RHEUMATIC DISEASES. vol. 75, 158-158.
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Rivellese F, Humby F, Kelly S, Nerviani A, Mauro D, Rocher-Ros V, El Shikh ME, de Paulis A et al. (2016). SYNOVIAL MAST CELLS CORRELATE WITH LOCAL AND SYSTEMIC INFLAMMATION AND ARE FUNCTIONALLY ASSOCIATED WITH ECTOPIC LYMPHOID STRUCTURES IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS. Presented at: EULAR 2016,
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Porter D, van Melckebeke J, Dale J, Messow CM, McConnachie A, Walker A, Munro R, McLaren J et al.(2016). Tumour necrosis factor inhibition versus rituximab for patients with rheumatoid arthritis who require biological treatment (ORBIT): an open-label, randomised controlled, non-inferiority, trial. Lancet vol. 388, (10041) 239-247.
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Nerviani A, DiCicco M, Kelly S, Humby F, Hands R, Zou L, Lewis M, Rocher V et al. (2016). FIBROID SYNOVIAL PATHOTYPE AND TYROSINE KINASE AXL CORRELATE WITH POOR CLINICAL RESPONSE TO CERTOLIZUMAB PEGOL IN RHEUMATOID ARTHRITIS PATIENTS. Rheumatology. Conference: Rheumatology 2016 from: 26/09/2016 to: 28/04/2016, vol. 55, 61-61.
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Lewis MJ, Vyse S, Shields AM, Zou L, Khamashta M, Gordon PA, Pitzalis C, Vyse TJ et al. (2016). CORRELATION OF SOLUBLE VASCULAR CELL ADHESION MOLECULE 1 WITH B CELL ACTIVATION AND PLASMA CELLS IN SYSTEMIC LUPUS ERYTHEMATOSUS. RHEUMATOLOGY. Conference: British Society for Rheumatology annual conference 2016 vol. 55, 145-146.
Eldridge SE, Petrycki E, Pitzalis C, Whiteford J, Dell'Accio F (2016). MMP3 CLEAVES AGRIN IN CARTILAGE AND REDUCES ITS CHONDROGENIC POTENCY. OSTEOARTHRITIS AND CARTILAGE. vol. 24, S379-S379.
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Pitzalis C (2016). STRATIFIED MEDICINE APPROACHES IN RHEUMATOID ARTHRITIS. RHEUMATOLOGY. vol. 55, 5-5.
DiCicco M, Humby F, Kelly S, Bombardieri M, Rebecca H, Rocher V, Zou L, Myles L et al. (2016). SYNOVIAL LYMPHOCYTIC AGGREGATES ASSOCIATE WITH HIGHLY ACTIVE RA AND PREDICT EROSIVE DISEASE PROGRESSION AT 12 MONTHS: RESULTS FROM THE PATHOBIOLOGY OF EARLY ARTHRITIS COHORT. RHEUMATOLOGY. vol. 55, 59-59.
Rivellese F, Humby F, Kelly S, Rocher V, Pitzalis C (2016). SYNOVIAL MAST CELLS CORRELATE WITH INFLAMMATION AND CELLULAR INFILTRATION AND ARE ASSOCIATED WITH ECTOPIC LYMPHOID STRUCTURES IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS. RHEUMATOLOGY. vol. 55, 89-90.
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Lepse N, Nerviani A, Pitzalis C, Bombardieri M (2016). T FOLLICULAR HELPER-LIKE CELLS IN THE RHEUMATOID ARTHRITIS SYNOVIUM ARE SELECTIVELY ASSOCIATED WITH INTERLEUKIN-21 PRODUCTION AND ECTOPIC LYMPHOID STRUCTURES. RHEUMATOLOGY. vol. 55, 89-89.
Nalesso G, Wagner K, Bertrand J, Sherwood JC, Thomas BL, Eldridge SE, Pitzalis C, Dell'Accio F (2016). Pharmacological Blockade of CAMKII is Detrimental for Osteoarthritis Progression. Osteoarthritis and Cartilage. Conference: 2016 OARSI World Congress on Osteoarthritis vol. 24 (Suppl 1), S149-S149.
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Oni C, Mitchell S, James K, Ng WF, Griffiths B, Hindmarsh V, Price E, Pease CT et al.(2016). Eligibility for clinical trials in primary Sjögren's syndrome: lessons from the UK Primary Sjögren's Syndrome Registry. Rheumatology (Oxford, England) vol. 55, (3) 544-552.
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Rivellese F, De Paulis A, Marone G, Pitzalis C, Toes REM(2016). Reply. Arthritis and Rheumatology vol. 68, (3) 769-770.
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Lepse N, Nerviani A, Pitzalis C, Bombardieri M (2016). TFH-LIKE CELLS IN THE RA SYNOVIUM ARE SELECTIVELY ASSOCIATED WITH IL-21 PRODUCTION AND ECTOPIC LYMPHOID STRUCTURES. ANNALS OF THE RHEUMATIC DISEASES. vol. 75, A27-A27.
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Corsiero E, Carlotti E, Prediletto E, Jagemann L, Pitzalis C, Bombardieri M (2016). THE ROLE OF SOMATIC HYPERMUTATION AND N-GLYCOSYLATION IN THE ANTI-NETS IMMUNOREACTIVITY OF RA SYNOVIAL MONOCLONAL ANTIBODIES. ANNALS OF THE RHEUMATIC DISEASES. vol. 75, A16-A16.
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De Groof A, Ducreux J, Humby F, Nzeusseu Toukap A, Badot V, Pitzalis C, Houssiau FA, Durez P et al.(2016). Higher expression of TNFaα-induced genes in the synovium of patients with early rheumatoid arthritis correlates with disease activity, and predicts absence of response to first line therapy. Arthritis Research and Therapy vol. 18, (1)
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Lewis MJ, Vyse S, Shields AM, Zou L, Khamashta M, Gordon PA, Pitzalis C, Vyse TJ et al.(2016). Improved monitoring of clinical response in Systemic Lupus Erythematosus by longitudinal trend in soluble vascular cell adhesion molecule-1. Arthritis Research and Therapy vol. 18, (1)
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Humby F, Kelly S, Bugatti S, Manzo A, Filer A, Mahto A, Fonseca JE, Lauwerys B et al.(2016). Evaluation of minimally invasive, ultrasound-guided synovial biopsy techniques by the OMERACT filter - Determining validation requirements. Journal of Rheumatology vol. 43, (1) 208-213.
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Ferrari M, Onuoha SC, Pitzalis C(2016). Going with the flow: harnessing the power of the vasculature for targeted therapy in rheumatoid arthritis. Drug Discov Today vol. 21, (1) 172-179.
10.1016/j.drudis.2015.10.014
Lazarou I, Kelly S, Humby F, DiCicco M, Zou L, Rocher-Ros V, Hands RE, Ng N et al.(2016). Ultrasound-guided synovial biopsy of the wrist does not alter subsequent clinical or ultrasound disease activity assessments: A prospective study for incorporation of imaging in clinical trials. Clinical and Experimental Rheumatology vol. 34, (5) 802-807.
Corsiero E, Bombardieri M, Carlotti E, Pratesi F, Robinson W, Migliorini P, Pitzalis C(2015). Single cell cloning and recombinant monoclonal antibodies generation from RA synovial B cells reveal frequent targeting of citrullinated histones of NETs. Annals of the Rheumatic Diseasesannrheumdis-2015-208-annrheumdis-2015-208.
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James K, Al-Ali S, Tarn J, Cockell SJ, Gillespie CS, Hindmarsh V, Locke J, Mitchell S et al.(2015). A transcriptional signature of fatigue derived from patients with primary Sjögren's syndrome. PLoS ONE vol. 10, (12)
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Headland SE, Jones HR, Norling LV, Kim A, Souza PR, Corsiero E, Gil CD, Nerviani A et al.(2015). Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis. Science Translational Medicine vol. 7, (315)
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Jones GW, Bombardieri M, Greenhill CJ, McLeod L, Nerviani A, Rocher-Ros V, Cardus A, Williams AS et al.(2015). Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis. Journal of Experimental Medicine vol. 212, (11) 1793-1802.
10.1084/jem.20132307
Murray-Brown W, Carlotti E, Tappuni A, Sutcliffe N, Pitzalis C, Bombardieri M(2015). Next-Generation Sequencing Demonstrates Dynamic Recirculation of B Cell Clones in Ectopic Lymphoid Structures of Sjogren's Syndrome. ARTHRITIS & RHEUMATOLOGY vol. 67,
Bowman S, Everett C, Bombardieri M, Busch R, Emery P, Hall F, Pease CT, Pitzalis C et al.(2015). Preliminary Results of a Double-Blind Randomised Trial of Rituximab Anti-B-Cell Therapy in Patients with Primary Sjogrens Syndrome. ARTHRITIS & RHEUMATOLOGY vol. 67,
Onuoha SC, Ferrari M, Sblattero D, Pitzalis C(2015). Rational design of antirheumatic prodrugs specific for sites of inflammation. Arthritis Rheumatol vol. 67, (10) 2661-2672.
10.1002/art.39232
DiCicco M, Humby F, Kelly S, Hands R, Ng N, Mahto A, Lazarou I, Rocher V et al.(2015). Synovial Lymphocytic Aggregates Associate with Highly Active RA and Predict Erosive Disease at 12 Months: Results from the Pathobiology of Early Arthritis Cohort. ARTHRITIS & RHEUMATOLOGY vol. 67,
Corsiero E, Carlotti E, Pitzalis C, Bombardieri M(2015). The Importance of Somatic Hypermutation for the Immunoreactivity Towards Neutrophil Extracellular Traps (NETs)-Citrullinated Autoantigens of RA Synovial Monoclonal Antibodies. ARTHRITIS & RHEUMATOLOGY vol. 67,
Humby F, Kelly S, Hands R, Rocher V, DiCicco M, Ng N, Zou L, Bugatti S et al.(2015). Use of ultrasound-guided small joint biopsy to evaluate the histopathologic response to rheumatoid arthritis therapy: recommendations for application to clinical trials. Arthritis Rheumatol vol. 67, (10) 2601-2610.
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Barone F, Nayara S, Camposa J, Cloakea T, Withers DR, Toellner KM, Zhang Y, Fouser L et al.(2015). IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs. Proceedings of the National Academy of Sciences of the United States of America vol. 112, (35) 11024-11029.
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Komarowska I, Coe D, Wang G, Haas R, Mauro C, Kishore M, Cooper D, Nadkarni S et al.(2015). Hepatocyte Growth Factor Receptor c-Met Instructs T Cell Cardiotropism and Promotes T Cell Migration to the Heart via Autocrine Chemokine Release. Immunity vol. 42, (6) 1087-1099.
10.1016/j.immuni.2015.05.014
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Nerviani A, Humby F, Kelly S, Bombardieri M, Pitzalis C (2015). A FUNCTIONAL INHIBITORY ROLE FOR THE GAS6/MERTK AXIS IN MODULATING SYNOVIAL INFLAMMATION IN RHEUMATOID ARTHRITIS. ANNALS OF THE RHEUMATIC DISEASES. vol. 74, 204-204.
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De Groof A, Humby F, Ducreux J, Kelly S, Toukap AN, Pitzalis C, Durez P, Lauwerys B (2015). HIGHER EXPRESSION OF TNF ALPHA-INDUCED GENES IN THE SYNOVIUM OF EARLY RA PATIENTS CORRELATES WITH DISEASE ACTIVITY, AND PREDICTS ABSENCE OF RESPONSE TO FIRST LINE THERAPY. ANNALS OF THE RHEUMATIC DISEASES. vol. 74, 117-117.
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Romao VC, DiCicco M, Lazarou I, Mahto A, Fonseca JE, Kelly S, Humby F, Pitzalis C (2015). HIGHER ULTRASOUND SYNOVITIS IN ELDERLY-ONSET RHEUMATOID ARTHRITIS AS COMPARED TO YOUNGER-ONSET: THE BARTS EARLY ARTHRITIS COHORT. ANNALS OF THE RHEUMATIC DISEASES. vol. 74, 236-236.
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Rivellese F, Suurmond J, Habets K, Dorjee AL, de Paulis A, Marone G, Pitzalis C, Huizinga TW et al. (2015). HUMAN MAST CELLS STIMULATED WITH IL-33 AND IMMUNE COMPLEXES DOWN-REGULATE MONOCYTE ACTIVATION IN RHEUMATOID ARTHRITIS. ANNALS OF THE RHEUMATIC DISEASES. vol. 74, 201-201.
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Nayar S, Campos J, Cloake T, Bowman S, Bombardieri M, Pitzalis C, Luther S, Buckley C et al. (2015). IL22 REGULATES AUTOANTIBODY PRODUCTION BY INDUCING LYMPHOID CHEMOKINE EXPRESSION IN TERTIARY LYMPHOID ORGANS. ANNALS OF THE RHEUMATIC DISEASES. vol. 74, 651-651.
10.1136/annrheumdis-2015-eular.5049
Carlotti E, Floyd J, Murray-Brown W, Barnes M, Mehr R, Bombardieri M, Pitzalis C (2015). LONGITUDINAL ANALYSIS OF THE IGH-VH GENE BY HIGH-THROUGHPUT SEQUENCING IN EARLY RHEUMATOID ARTHRITIS PAIRED BIOPSIES AND ITS ASSOCIATION WITH RESPONSE TO DMARDS. ANNALS OF THE RHEUMATIC DISEASES. vol. 74, 422-422.
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Ferrari M, Onuoha SC, Sblattero D, Pitzalis C (2015). SYNOVIAL SPECIFIC PRODRUG FOR THE NEXT GENERATION OF ANTI-TNF THERAPY IN RHEUMATOID ARTHRITIS. ANNALS OF THE RHEUMATIC DISEASES. vol. 74, 456-457.
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Corsiero E, Carlotti E, Pitzalis C, Bombardieri M (2015). THE IMPORTANCE OF SOMATIC HYPERMUTATION FOR THE IMMUNOREACTIVITY TOWARDS NEUTROPHIL EXTRACELLULAR TRAPS (NETS)-CITRULLINATED AUTOANTIGENS OF RA SYNOVIAL MONOCLONAL ANTIBODIES. ANNALS OF THE RHEUMATIC DISEASES. vol. 74, 422-422.
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Ferrari M, Onuoha SC, Pitzalis C(2015). Trojan horses and guided missiles: targeted therapies in the war on arthritis. Nat Rev Rheumatol vol. 11, (6) 328-337.
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Astorri E, Nerviani A, Bombardieri M, Pitzalis C(2015). Towards a stratified targeted approach with biologic treatments in rheumatoid arthritis: Role of synovial pathobiology. Current Pharmaceutical Design vol. 21, (17) 2216-2224.
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Sin W, Tan G, Di Cicco M, Mahto A, Lazarou I, Hands R, Kelly S, Pitzalis C (2015). A COMPARISON OF CLINICAL AND SYNOVIAL IMMUNOHISTOCHEMICAL CHARACTERISTICS BETWEEN PSORIATIC ARTHRITIS AND RHEUMATOID ARTHRITIS IN AN EARLY ARTHRITIS COHORT. RHEUMATOLOGY. vol. 54, 138-138.
Mahto A, Lazarou I, Ng N, DiCicco M, Tan G, Humby F, Pitzalis C, Kelly S (2015). AN ESSENTIAL PART OF THE RHEUMATOLOGIST'S TOOLKIT? AN AUDIT OF A RHEUMATOLOGY LED ULTRASOUND GUIDED SYNOVIAL BIOPSY SERVICE. RHEUMATOLOGY. vol. 54, 93-94.
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Shields AM, Vyse S, Walczak H, Lehner PH, Pitzalis C, Spector TD, Vyse TJ, Lewis MJ (2015). THE AUTOIMMUNE RISK GENE UBE2L3 IS HIGHLY EXPRESSED DURING B CELL PROLIFERATION AND IS CORRELATED WITH PLASMABLAST AND PLASMA CELL EXPANSION IN SLE. RHEUMATOLOGY. vol. 54, 41-41.
Kelly S, Bombardieri M, Humby F, Ng N, Marrelli A, Riahi S, DiCicco M, Mahto A et al.(2015). Angiogenic gene expression and vascular density are reflected in ultrasonographic features of synovitis in early rheumatoid arthritis: An observational study. Arthritis Research and Therapy
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Romao VC, DiCicco M, Mahto A, Lazarou I, Fonseca JE, Kelly S, Humby F, Pitzalis C (2015). CLINICAL AND PATHOLOGICAL DIFFERENCES OF ELDERLY- AND YOUNGER-ONSET RHEUMATOID ARTHRITIS IN AN EARLY ARTHRITIS COHORT. ANNALS OF THE RHEUMATIC DISEASES. vol. 74, A76-A77.
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Ferrari M, Onuoha SC, Sblattero D, Pitzalis C (2015). TISSUE SPECIFIC PRO-DRUG FOR THE NEXT GENERATION OF ANTI-TNF THERAPY IN RHEUMATOID ARTHRITIS. ANNALS OF THE RHEUMATIC DISEASES. vol. 74, A88-A89.
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Kelly S, Humby F, Filer A, Ng N, Di Cicco M, Hands RE, Rocher V, Bombardieri M et al.(2015). Ultrasound-guided synovial biopsy: a safe, well-tolerated and reliable technique for obtaining high-quality synovial tissue from both large and small joints in early arthritis patients. Ann Rheum Dis vol. 74, (3) 611-617.
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Haas R, Smith J, Rocher-Ros V, Nadkarni S, Montero-Melendez T, D¿Acquisto F, Bland EJ, Bombardieri M et al.(2015). Lactate regulates metabolic and proinflammatory circuits in control of T cell migration and effector functions. PLoS Biology vol. 13, (7)
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Romão VC, Pitzalis C(2015). Synovial heterogeneity in rheumatoid arthritis: the key for rational patient stratification?. Acta Reumatol Port vol. 40, (1) 6-8.
Corsiero E, Bombardieri M, Carlotti E, Pratesi F, Robinson W, Migliorini P, Pitzalis C(2014). Citrullinated histones from neutrophil extracellular traps (NETs) fuel ectopic germinal centre responses and ACPA production in rheumatoid joints. IMMUNOLOGY vol. 143, 43-43.
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Haas R, Smith J, Rocher-Ros V, Montero-Melendez T, D'Acquisto F, Bland EJ, Bombardieri M, Pitzalis C et al.(2014). How the microenvironment contributes to the establishment of chronic inflammatory diseases: lactate regulates metabolic and pro-inflammatory circuits in control of T cell migration and functions. IMMUNOLOGY vol. 143, 151-151.
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Lucchesi D, Pontarini E, Pitzalis C, Bombardieri M(2014). Innate immune system early activation precedes the formation of functional tertiary lymphoid structures in a novel model of salivary gland ectopic lymphoid neogenesis. IMMUNOLOGY vol. 143, 95-95.
Bugatti S, Manzo A, Vitolo B, Benaglio F, Binda E, Scarabelli M, Humby F, Caporali R et al.(2014). High expression levels of the B cell chemoattractant CXCL13 in rheumatoid synovium are a marker of severe disease. Rheumatology (Oxford) vol. 53, (10) 1886-1895.
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Ng N, Kelly S, Humby F, DiCicco M, Rocher V, Hands R, Bombardieri M, Pitzalis C(2014). Ultrasound Synovitis Reflects Synovial Inflammation at a Histopathological Level. ARTHRITIS & RHEUMATOLOGY vol. 66, S400-S400.
Genovese MC, Fleischmann R, Furst D, Janssen N, Carter J, Dasgupta B, Bryson J, Duncan B et al.(2014). Efficacy and safety of olokizumab in patients with rheumatoid arthritis with an inadequate response to TNF inhibitor therapy: outcomes of a randomised Phase IIb study. Ann Rheum Dis vol. 73, (9) 1607-1615.
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Croia C, Astorri E, Murray-Brown W, Willis A, Brokstad KA, Sutcliffe N, Piper K, Jonsson R et al.(2014). Implication of Epstein-Barr virus infection in disease-specific autoreactive B cell activation in ectopic lymphoid structures of Sjögren's syndrome. Arthritis Rheumatol vol. 66, (9) 2545-2557.
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Pitzalis C(2014). Pathogenesis of rheumatoid arthritis: from systemic autoimmunity to localised joint disease. Drug Discov Today vol. 19, (8) 1152-1154.
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Corsiero E, Pitzalis C, Bombardieri M(2014). Peripheral and synovial mechanisms of humoral autoimmunity in rheumatoid arthritis. Drug Discov Today vol. 19, (8) 1161-1165.
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Ahmed TJ, Kaneva MK, Pitzalis C, Cooper D, Perretti M(2014). Resolution of inflammation: examples of peptidergic players and pathways. Drug Discov Today vol. 19, (8) 1166-1171.
10.1016/j.drudis.2014.05.020
Pitzalis C, Jones GW, Bombardieri M, Jones SA(2014). Ectopic lymphoid-like structures in infection, cancer and autoimmunity. Nat Rev Immunol vol. 14, (7) 447-462.
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Lendrem D, Mitchell S, McMeekin P, Bowman S, Price E, T Pease C, Emery P, Andrews J et al.(2014). Health-related utility values of patients with primary Sjögren's syndrome and its predictors. Annals of the Rheumatic Diseases vol. 73, (7) 1362-1368.
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Astorri E, Tappuni A, Sutcliffe N, Richards P, Pitzalis C, Bombardieri M (2014). A NEGATIVE HIGH-RESOLUTION SALIVARY GLAND ULTRASOUND IS HIGHLY PREDICTIVE OF NEGATIVE LABIAL GLAND BIOPSY IN PATIENTS WITH SICCA SYMPTOMS. ANNALS OF THE RHEUMATIC DISEASES. vol. 73, 179-179.
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Eldridge S, Vicente-Greco K, Nalesso G, Pitzalis C, Perretti M, Kabouridis P, Dell'Accio F (2014). Agrin expression is downregulated in OA and is required for chondrocyte differentiation. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 95, A8-A9.
Mahto A, Humby F, Ng N, DiCicco M, Rocher V, Lazarou I, Hands R, Gregoriadou S et al. (2014). BASELINE SYNOVIAL B-CELL STATUS PREDICTS RESPONSE TO RITUXIMAB THERAPY IN RA. ANNALS OF THE RHEUMATIC DISEASES. vol. 73, 72-72.
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Corsiero E, Carlotti E, Pratesi F, Wardemann H, Robinson W, Migliorini P, Pitzalis C, Bombardieri M (2014). MONOCLONAL ANTIBODIES DERIVED FROM SINGLE CD19+SYNOVIAL B CELLS OF RA PATIENTS WITH TERTIARY LYMPHOID STRUCTURES DISPLAY PREFERENTIAL IMMUNOREACTIVITY TOWARDS CITRULLINATED PROTEINS OF NETS. ANNALS OF THE RHEUMATIC DISEASES. vol. 73, 162-162.
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Di Cicco M, Humby F, Kelly S, Ng N, Mahto A, Hands R, Rocher V, Bombardieri M et al. (2014). PRESENCE OF SYNOVIAL LYMPHOCYTE AGGREGATES CORRELATES WITH A MORE SEVERE CLINICAL PHENOTYPE IN PATIENTS WITH EARLY INFLAMMATORY ARTHRITIS. ANNALS OF THE RHEUMATIC DISEASES. vol. 73, 847-847.
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Di Cicco M, Humby FC, Kelly S, Ng N, Mahto A, Hands R, Rocher V, Zou L et al. (2014). PRESENCE OF SYNOVIAL LYMPHOCYTE AGGREGATES PREDICTS CLINICAL RESPONSE TO DMARD THERAPY IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS. ANNALS OF THE RHEUMATIC DISEASES. vol. 73, 388-388.
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Di Cicco M, Kelly S, Humby F, Ng N, Nerviani A, Rocher V, Hands R, Bombardieri M et al. (2014). SYNOVIAL LYMPHOCYTIC AGGREGATES PREDICT CLINICAL RESPONSE TO CERTOLIZUMAB PEGOL IN RHEUMATOID ARTHRITIS (CLINICAL AND PATHOLOGICAL RESPONSE TO CERTOLIZUMAB-PEGOL (CLIP-CERT) STUDY). ANNALS OF THE RHEUMATIC DISEASES. vol. 73, 606-607.
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Nalesso G, Thomas B, Wagner K, Bertrand J, Sherwood J, Eldridge S, Pap T, Achan P et al. (2014). The WNT/CaMKII pathway is activated in human and experimental osteoarthritis and promotes chondrocyte de-differentiation. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 95, A25-A26.
Ng N, Kelly S, Humby F, DiCicco M, Rocher V, Hands R, Bombardieri M, Pitzalis C (2014). ULTRASOUND SYNOVITIS REFLECTS SYNOVIAL INFLAMMATION AT A HISTOPATHOLOGICAL LEVEL. ANNALS OF THE RHEUMATIC DISEASES. vol. 73, 81-81.
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Lazarou I, Zou L, Mahto A, Di Cicco M, Ng N, Humby F, Pitzalis C, Kelly S (2014). ULTRASOUND-GUIDED SYNOVIAL BIOPSY DOES NOT ALTER SUBSEQUENT ULTRASOUND ASSESSMENTS. ANNALS OF THE RHEUMATIC DISEASES. vol. 73, 471-471.
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Headland S, Norling L, Patel H, Dalli J, Kelly S, Pitzalis C, Dell'Accio F, Perretti M (2014). A novel mechanism for protecting the arthritic joint: microparticles deliver Annexin A1 into cartilage. FASEB JOURNAL. vol. 28,
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Lucchesi D, Pitzalis C, Bombardieri M(2014). EBV and other viruses as triggers of tertiary lymphoid structures in primary Sjögren's syndrome. Expert Rev Clin Immunol vol. 10, (4) 445-455.
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Pitzalis C (2014). FROM THE DISEASE TISSUE TO THE WHOLE PATIENT: THE ROLE OF PATHOBIOLOGY IN PATIENT STRATIFICATION. RHEUMATOLOGY. vol. 53, 22-23.
Al-Mousawi AZ, El Shikh MEM, Pitzalis C (2014). IMMUNE COMPLEX RETENTION BY SYNOVIAL FIBROBLASTS IN RHEUMATOID ARTHRITIS. RHEUMATOLOGY. vol. 53, 84-84.
Di Cicco M, Humby F, Kelly S, Ng N, Mahto A, Hands RE, Rocher V, Buckley C et al. (2014). PRESENCE OF SYNOVIAL LYMPHOCYTE AGGREGATES CORRELATES WITH A MORE SEVERE CLINICAL PHENOTYPE IN PATIENTS WITH EARLY INFLAMMATORY ARTHRITIS. RHEUMATOLOGY. vol. 53, 48-48.
Mahto A, Ng N, DiCicco M, Rocher V, Hands R, Kelly S, Humby F, Pitzalis C (2014). SYNOVIAL B-CELLS PREDICT RESPONSE/RESISTANCE TO RITUXIMAB THERAPY IN RHEUMATOID ARTHRITIS: PRELIMINARY RESULTS FROM A PILOT STUDY. RHEUMATOLOGY. vol. 53, 98-98.
Di Cicco M, Kelly S, Humby F, Ng N, Hands RE, Rocher V, Nerviani A, Zou L et al. (2014). SYNOVIAL ECTOPIC LYMPHONEOGENESIS PREDICTS PRIMARY CLINICAL RESPONSE TO CERTOLIZUMAB PEGOL IN PATIENTS WITH RHEUMATOID ARTHRITIS. RHEUMATOLOGY. vol. 53, 95-95.
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Ahmed TJ, Perretti M, Pitzalis C (2014). TRANSLATIONAL MEDICINE IN RHEUMATOID ARTHRITIS: EXPLOITING MELANOCORTIN RECEPTORS. RHEUMATOLOGY. vol. 53, 85-86.
Ng N, Kelly S, Humby F, Di Cicco M, Rocher V, Hands RE, Bombardieri M, Pitzalis C (2014). ULTRASOUND MEASURES OF SYNOVITIS REFLECTS HISTOLOGICAL SYNOVIAL INFLAMMATION IN EARLY ARTHRITIS PATIENTS. RHEUMATOLOGY. vol. 53, 45-45.
Ng N, Humby F, Di Cicco M, Deidda S, Mahto A, Pyne D, Kidd B, Bombardieri M et al. (2014). ULTRASOUND-GUIDED DIAGNOSTIC SYNOVIAL BIOPSIES: AN AUDIT OF A RHEUMATOLOGY-LED SERVICE. RHEUMATOLOGY. vol. 53, 105-106.
Nalesso G, Thomas BL, Sherwood J, Schett G, Dale L, Addimanda O, Eltawil N, Pitzalis C et al. (2014). WNT16 IS INDUCED BY OXIDATIVE STRESS FOLLOWING CARTILAGE INJURY AND CONTRIBUTES TO CARTILAGE HOMEOSTASIS IN OSTEOARTHRITIS. OSTEOARTHRITIS AND CARTILAGE. vol. 22, S8-S9.
10.1016/j.joca.2014.02.037
Thomas BL, Nalesso G, Sherwood J, Bertrand J, Achan P, Pitzalis C, Dell'Accio F (2014). WNT16 SUPPORTS THE PHENOTYPE OF THE SUPERFICIAL ZONE CELLS IN CARTILAGE. OSTEOARTHRITIS AND CARTILAGE. vol. 22, S160-S160.
10.1016/j.joca.2014.02.298
Kam NW, Brentano F, Kyburz D, Gay S, Filer A, Buckley C, Pitzalis C, Bombardieri M(2014). A1.12 Endogenous SLPI released by rheumatoid synovial fibroblasts control BAFF-dependent-B cell activation in vitro and in the CIA and RA/SCID-arthritis models. Ann Rheum Dis vol. 73 Suppl 1,
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Ferrari M, Onuoha S, Sblattero D, Pitzalis C (2014). DEVELOPMENT OF A NOVEL BISPECIFIC THERAPEUTIC FOR RHEUMATOID ARTHRITIS. ANNALS OF THE RHEUMATIC DISEASES. vol. 73, A23-A23.
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Corsiero E, Carlotti E, Wardemann H, Robinson W, Migliorini P, Pratesi F, Pitzalis C, Bombardieri M (2014). MONOCLONAL ANTIBODIES FROM CD19(+) SYNOVIAL B CELLS OF RA PATIENTS WITH TERTIARY LYMPHOID STRUCTURES DISPLAY A STRONG IMMUNOREACTIVITY TOWARDS CITRULLINATED HISTONES FROM NEUTROPHILS NETS. ANNALS OF THE RHEUMATIC DISEASES. vol. 73, A13-A13.
10.1136/annrheumdis-2013-205124.30
Brown S, Coy NN, Pitzalis C, Emery P, Pavitt S, Gray J, Hulme C, Hall F et al.(2014). The TRACTISS Protocol: a randomised double blind placebo controlled clinical TRial of Anti-B-Cell Therapy In patients with primary Sjogren's Syndrome. BMC MUSCULOSKELETAL DISORDERS vol. 15, Article ARTN 21,
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Corsiero E, Sutcliffe N, Pitzalis C, Bombardieri M(2014). Accumulation of self-reactive naïve and memory B cell reveals sequential defects in B cell tolerance checkpoints in Sjögren's syndrome. PLoS One vol. 9, (12)
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Juarez M, Toms TE, De Pablo P, Mitchell S, Bowman S, Nightingale P, Price EJ, Griffiths B et al.(2014). Cardiovascular risk factors in women with primary Sjögren's syndrome: United Kingdom primary Sjögren's syndrome registry results. Arthritis Care and Research vol. 66, (5) 757-764.
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Nordmark G, Wang C, Vasaitis L, Eriksson P, Theander E, Kvarnström M, Forsblad-d'Elia H, Jazebi H et al.(2013). Association of genes in the NF-κB pathway with antibody-positive primary Sjögren's syndrome. Scand J Immunol vol. 78, (5) 447-454.
10.1111/sji.12101
El Shikh ME, Kmieciak M, Manjili MH, Szakal AK, Pitzalis C, Tew JG(2013). Multi-therapeutic potential of autoantibodies induced by immune complexes trapped on follicular dendritic cells. Hum Vaccin Immunother vol. 9, (11) 2434-2444.
10.4161/hv.25596
Ferrari M, Onuoha S, Kamalati T, Sblattero D, Pitzalis C (2013). Development Of a Novel Bispecific Therapeutic For Arthritic Diseases. ARTHRITIS AND RHEUMATISM. vol. 65, S218-S218.
Murray-Brown W, Croia C, Sutcliffe N, Tappuni A, Pitzalis C, Bombardieri M (2013). Lesional Intereukin-21 Expression Correlates With Functional Germinal Center Formation and T Follicular Helper Cell Infiltration In The Salivary Glands Of Sjogren's Syndrome. ARTHRITIS AND RHEUMATISM. vol. 65, S634-S634.
Corsiero E, Bombardieri M, Carlotti E, Wardemann H, Robinson WH, Pitzalis C (2013). Recombinant Monoclonal Antibodies Derived From Single CD19+Synovial B Cells Of RA Patients With Tertiary Lymphoid Structures Display a Strong Immunoreactivity Towards Citrullinated Histones. ARTHRITIS AND RHEUMATISM. vol. 65, S1127-S1128.
Kam YNW, Filer A, Buckley CD, Pitzalis C, Bombardieri M (2013). Secretory Leukocyte Protease Inhibitor Released By Rheumatoid Synovial Fibroblasts Exerts a Negative Control Of BAFF-Dependent B Cell Activation In Vitro and In Vivo In The Collagen-Induced and Chimeric RA/SCID Arthritis Models. ARTHRITIS AND RHEUMATISM. vol. 65, S1029-S1029.
Di Cicco M, Kelly S, Humby F, Ng N, Dadoun S, Hands R, Rocher V, Nerviani A et al. (2013). Synovial Ectopic Lymphoneogenesis Predicts Clinical Response To Certolizumab Pegol In Patients With Rheumatoid Arthritis. ARTHRITIS AND RHEUMATISM. vol. 65, S556-S556.
Croia C, Serafini B, Bombardieri M, Kelly S, Humby F, Severa M, Rizzo F, Coccia EM et al.(2013). Epstein-Barr virus persistence and infection of autoreactive plasma cells in synovial lymphoid structures in rheumatoid arthritis. Ann Rheum Dis vol. 72, (9) 1559-1568.
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Jones GW, Bombardieri M, Greenhill CJ, McLeod L, Rocher V, Williams AS, Pitzalis C, Jenkins BJ et al. (2013). Interleukin-27 as a novel antagonist of ectopic lymphoid-like structure development in early inflammatory arthritis. CYTOKINE. vol. 63, 274-274.
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Lendrem D, Mitchell S, McMeekin P, Bowman S, Price E, Pease CT, Emery P, Andrews J et al.(2013). Health-related utility values of patients with primary Sjögren's syndrome and its predictors. Annals of the Rheumatic Diseases
10.1136/annrheumdis-2012-202863
Pitzalis C(2013). "HUMAN SCID CHIMERAS: MODELS TO DISSECT AUTOIMMUNITY AND INFLAMMATION". ANNALS OF THE RHEUMATIC DISEASES vol. 71, 40-40.
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Sherwood J, Nalesso G, Bertrand J, Achan P, Brandolini L, Pap T, Pitzalis C, Dell'Accio F(2013). A NOVEL ROLE FOR ELR plus CXC CHEMOKINE SIGNALING IN CARTILAGE HOMEOSTASIS. ANNALS OF THE RHEUMATIC DISEASES vol. 71, 161-161.
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Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M(2013). ACCUMULATION OF CIRCULATING AUTOREACTIVE NAIVE B CELLS REVEAL DEFECTS OF EARLY B CELL TOLERANCE CHECKPOINTS IN PATIENTS WITH SJOGREN'S SYNDROME. ANNALS OF THE RHEUMATIC DISEASES vol. 72, 792-792.
Croia C, Serafini B, Tappuni A, Aloisi F, Sutcliffe N, Pitzalis C, Bombardieri M(2013). ECTOPIC LYMPHOID STRUCTURES SUPPORT EPSTEIN-BARR VIRUS PERSISTENCE AND AUTOREACTIVE PLASMA CELL INFECTION IN SJOGREN'S SYNDROME SALIVARY GLANDS. ANNALS OF THE RHEUMATIC DISEASES vol. 72, 462-462.
Ng W-F, Lendrem D, Mitchell S, Bowman S, Price E, Pease C, Emery P, Andrews J et al.(2013). EVALUATING HEALTH STATUS OF 620 PATIENTS WITH PRIMARY SJOGREN'S SYNDROME USING EQ-5D. ANNALS OF THE RHEUMATIC DISEASES vol. 71, 466-466.
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Nayar S, Cloake T, Lane P, Pitzalis C, Coles M, Luther S, Buckley C, Barone F(2013). IL-22 REGULATES LYMPHOID STROMAL CELL EXPANSION, DEVELOPMENT OF GERMINAL CENTERS AND HUMORAL RESPONSE IN MUCOSAL ECTOPIC LYMPHONEOGENESIS. ANNALS OF THE RHEUMATIC DISEASES vol. 72, 140-140.
Murray-Brown W, Croia C, Sutcliffe N, Tappuni A, Vartoukian S, Fortune F, Pitzalis C, Bombardieri M(2013). LESIONAL IL-21 EXPRESSION CORRELATES WITH FUNCTIONAL GERMINAL CENTER FORMATION AND T FOLLICULAR HELPER CELL INFILTRATION IN THE SALIVARY GLANDS OF SJOGREN'S SYNDROME. ANNALS OF THE RHEUMATIC DISEASES vol. 72, 77-77.
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Bombardieri M, Rocher V, Mittereder N, Carlesso G, Herbst R, Sleeman M, Pitzalis C(2013). MAVRILIMUMAB REDUCES PRO-INFLAMMATORY CYTOKINES AND CD68 POSITIVE MACROPHAGES IN SYNOVIAL EXPLANTS FROM RHEUMATOID ARTHRITIS SUBJECTS ENGRAFTED INTO SCID/BEIGE MICE. ANNALS OF THE RHEUMATIC DISEASES vol. 72, 156-157.
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El Shikh ME, Biggioggero M, El Sayed R, Kmieciak M, Manjili M, Szakal A, Meroni PL, Pitzalis C et al.(2013). REGULATION OF AUTO-ANTIBODY PRODUCTION BY AUTO-IMMUNE COMPLEXES ON FOLLICULAR DENDRITIC CELLS. ANNALS OF THE RHEUMATIC DISEASES vol. 71, 129-129.
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Ng N, Humby F, Kelly S, Di Cicco M, Dadoun S, Bombardieri M, Hands R, Rocher V et al.(2013). RHEUMATOID ARTHRITIS PATIENT CHARACTERISTICS AT DIFFERENT THERAPEUTIC TIMEPOINTS. ANNALS OF THE RHEUMATIC DISEASES vol. 72, 862-862.
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Pitzalis C, Kelly S, Humby F(2013). New learnings on the pathophysiology of RA from synovial biopsies. Curr Opin Rheumatol vol. 25, (3) 334-344.
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Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M (2013). ACCUMULATION OF CIRCULATING AUTOREACTIVE NAIVE B CELLS REVEALS DEFECTS OF EARLY B-CELL TOLERANCE CHECKPOINTS IN PATIENTS WITH SJOGREN'S SYNDROME. RHEUMATOLOGY. vol. 52, 159-159.
Eldridge S, Vicent-Greco K, Nalesso G, Pitzalis C, Perretti M, Kabouridis P, Dell'Accio F(2013). AGRIN EXPRESSION IS DOWNREGULATED IN OA AND IS REQUIRED FOR CHONDROCYTE DIFFERENTIATION. OSTEOARTHRITIS AND CARTILAGE vol. 21, S112-S113.
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Kam NW, Filter A, Buckley C, Pitzalis C, Bombardieri M (2013). MEMBRANE-BOUND AND SOLUBLE BAFF EXPRESSION BY HUMAN RHEUMATOID FIBROBLAST-LIKE SYNOVIOCYTES IN RESPONSE TO TLR STIMULATION. RHEUMATOLOGY. vol. 52, 80-80.
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Sherwood J, Bertrand J, Nalesso G, Achan P, Pitzalis C, Pap T, Dell'Accio F (2013). THE ROLE OF CXCR2 SIGNALING IN ARTICULAR CARTILAGE HOMEOSTASIS. OSTEOARTHRITIS AND CARTILAGE. vol. 21, S19-S20.
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Lucchesi D, Bombardieri M, Barone F, Nayar S, Proctor G, Buckley CD, Pitzalis C (2013). INDUCIBLE TERTIARY LYMPHOID STRUCTURES AND AUTOIMMUNITY IN A NOVEL MODEL OF SIALOADENITIS IN WILD-TYPE MICE. ANNALS OF THE RHEUMATIC DISEASES. vol. 72, A42-A42.
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Bombardieri M, Barone F, Lucchesi D, Nayar S, van den Berg WB, Proctor G, Buckley CD, Pitzalis C(2012). Inducible tertiary lymphoid structures, autoimmunity, and exocrine dysfunction in a novel model of salivary gland inflammation in C57BL/6 mice. J Immunol vol. 189, (7) 3767-3776.
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Jones GW, Greenhill CJ, Williams AS, Nowell MA, Bombardieri M, Pitzalis C, Jenkins BJ, Jones SA (2012). IL-27 control of ectopic lymphoid structures in inflammatory arthritis. IMMUNOLOGY. vol. 137, 44-44.
Lucchesi D, Bombardieri M, Barone F, Nayar S, Proctor G, Buckley CD, Pitzalis C (2012). Inducible tertiary lymphoid structures formation in a novel model of sialoadenitis in wild-type mice is preceded by ectopic expression of lymphoid chemokines. IMMUNOLOGY. vol. 137, 189-189.
Murray-Brown W, Croia C, Sutcliffe N, Tappuni A, Vartoukian S, Fortune F, Pitzalis C, Bombardieri M (2012). Lesional IL-21 expression correlates with functional germinal center formation and T follicular helper cell infiltration in the salivary glands of Sjogren's syndrome. IMMUNOLOGY. vol. 137, 491-491.
Nayar S, Chung MM, Rankin P, Cloake T, Pitzalis C, Lane P, Buckley C, Barone F (2012). Lymphotoxin beta regulates lymphatic vessel expansion in mucosal ectopic lymphoneogenesis. IMMUNOLOGY. vol. 137, 430-430.
Kam NW, Filer A, Buckley C, Bombardieri M, Pitzalis C (2012). Membrane-bound and soluble BAFF expression by human rheumatoid fibroblast-like synoviocytes in response to TLR stimulation. IMMUNOLOGY. vol. 137, 583-584.
Sherwood J, Nalesso G, Bertrand J, Pap T, Achan P, Pitzalis C, Dell'Accio F (2012). ELR plus CXC chemokine signaling is required for phenotypic stability of human articular chondrocytes. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 93, A6-A7.
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Nalesso G, Sherwood J, Bertrand J, Pap T, Ramachandran M, De Bari C, Pitzalis C, Dell'Accio F (2012). WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 93, A8-A8.
Corsiero E, Bombardieri M, Manzo A, Bugatti S, Uguccioni M, Pitzalis C(2012). Role of lymphoid chemokines in the development of functional ectopic lymphoid structures in rheumatic autoimmune diseases. Immunol Lett vol. 145, (1-2) 62-67.
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Patel HB, Kornerup KN, Sampaio ALFS, D'Acquisto F, Seed MP, Girol AP, Gray M, Pitzalis C et al.(2012). The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis. Annals of the Rheumatic Diseases
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Pitzalis C (2012). ADVANCES IN PATHOGENESIS: THE RHEUMATOLOGY VIEW: WHAT BIOLOGICAL PROCESSES DRIVE DIFFERENT DISEASE EXPRESSIONS IN PSA?. RHEUMATOLOGY. vol. 51, 15-15.
Croia C, Bombardieri M, Francesca A, Serafini B, Humby F, Kelly S, Migliorini P, Pitzalis C (2012). ANTI-VCA AND EBNA1 ANTIBODIES ARE PRODUCED IN THE RHEUMATOID SYNOVIUM IN THE PRESENCE OF ECTOPIC LYMPHOID STRUCTURES AND CORRELATE WITH ACPA PRODUCTION. RHEUMATOLOGY. vol. 51, 43-43.
Ferrari M, Kamalati T, Pitzalis C (2012). DEVELOPMENT OF A NOVEL RECOMBINANT BIOTHERAPEUTIC WITH APPLICATIONS IN TARGETED THERAPY OF HUMAN ARTHRITIS. RHEUMATOLOGY. vol. 51, 123-123.
Nayar S, Cloake T, Bombardieri M, Pitzalis C, Buckley C, Barone F (2012). ECTOPIC LYMPHONEOGENESIS IN A NOVEL MURINE MODEL OF SALIVARY GLANDS SIALOADENITIS IS CHARACTERIZED BY ASYNCHRONY IN THE LYMPHANGIOGENETIC AND ANGIOGENETIC PROGRAM. RHEUMATOLOGY. vol. 51, 143-144.
Lendrem D, Mitchell S, Bowman S, Price E, Pease CT, Emery P, Andrews J, Bombardieri M et al. (2012). EVALUATING HEALTH STATUS OF 620 PATIENTS WITH PRIMARY SJOGREN'S SYNDROME USING EQ-5D. RHEUMATOLOGY. vol. 51, 171-171.
Lendrem D, Mitchell S, Bowman S, Price E, Pease CT, Emery P, Andrews J, Bombardieri M et al. (2012). HOW GOOD ARE THE EULAR SJOGREN'S SYNDROME DISEASE ACTIVITY INDEX, AND EULAR SJOGREN'S SYNDROME PATIENTS REPORTED INDEX IN PREDICTING HEALTH STATUS IN PRIMARY SJOGREN'S SYNDROME?. RHEUMATOLOGY. vol. 51, 176-176.
Whitehead MA, Bombardieri M, Pitzalis C, Vanhaesebroeck B(2012). Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter. Biochem J vol. 443, (3) 857-867.
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Murray-Brown W, Priori R, Tappuni T, Vartoukian S, Seoudi N, Picarelli G, Fortune F, Valesini G et al. (2012). MONOCYTE-DERIVED IL-32 EXPRESSION CORRELATES WITH THE LEVEL OF INFLAMMATION IN SALIVARY GLANDS OF SJOGREN'S SYNDROME. RHEUMATOLOGY. vol. 51, 176-176.
Vila J, Mitchell S, Bowman S, Price E, Pease CT, Emery P, Andrews J, Bombardieri M et al. (2012). THE CLINICAL RELEVANCE OF ANTI-RO52 AND ANTI-RO60 IN PATIENTS IN THE UNITED KINGDOM PRIMARY SJOGREN'S SYNDROME REGISTRY (UKPSSR). RHEUMATOLOGY. vol. 51, 35-35.
DiCicco M, Humby F, Kelly S, Hands R, Buckley C, McInnes I, Taylor P, Bombardieri M et al. (2012). THE PATHOBIOLOGY OF EARLY ARTHRITIS COHORT: A PRELIMINARY ANALYSIS CORRELATING HISTOMORPHOLOGY AND DISEASE ACTIVITY. RHEUMATOLOGY. vol. 51, 149-149.
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Bombardieri M, Lucchesi D, Barone F, Nayar S, Proctor G, Buckley CD, Pitzalis C (2011). Inducible functional tertiary lymphoid structures, autoimmunity and exocrine dysfunction in wild-type mouse salivary glands via local adenoviral delivery. IMMUNOLOGY. vol. 135, 167-167.
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Croia C, Bombardieri M, Serafini B, Coccia EM, Severa M, Kelly S, Aloisi F, Pitzalis C (2011). EBV Infection In the Rheumatoid Synovium: Relationship with Ectopic Lymphoid Structures, In Situ Autoantobody Production and CD8 T Cell Activation. ARTHRITIS AND RHEUMATISM. vol. 63, S140-S140.
Bugatti S, Manzo A, Bombardieri M, Vitolo B, Humby F, Kelly S, Montecucco C, Pitzalis C(2011). Synovial Tissue Heterogeneity and Peripheral Blood Biomarkers. CURRENT RHEUMATOLOGY REPORTS vol. 13, (5) 440-448.
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de Hair MJH, Harty LC, Gerlag DM, Pitzalis C, Veale DJ, Tak PP(2011). Synovial Tissue Analysis for the Discovery of Diagnostic and Prognostic Biomarkers in Patients with Early Arthritis. J RHEUMATOL vol. 38, (9) 2068-2072.
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Macor P, Durigutto P, De Maso L, Fischetti F, Cortini A, Edomi P, Pitzalis C, Tedesco F (2011). Treatment of antigen-induced and collagen-induced arthritis by targeting synovial endothelium with a neutralizing recombinant antibody to C5. MOLECULAR IMMUNOLOGY. vol. 48, 1676-1676.
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Nalesso G, Sherwood J, Bertrand J, Pap T, Ramachandran M, De Bari C, Pitzalis C, Dell'accio F(2011). WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways. J Cell Biol vol. 193, (3) 551-564.
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El Shikh ME, El Sayed R, Kmieciak M, Manjili M, Szakal A, Pitzalis C, Tew J (2011). BREAKAGE OF B CELL TOLERANCE BY ANTIGENS ON FOLLICULAR DENDRITIC CELLS. RHEUMATOLOGY. vol. 50, 51-51.
Pitzalis C (2011). CAN PATHOBIOLOGY INFORM DISEASE OUTCOME AND RESPONSE TO THERAPY?. RHEUMATOLOGY. vol. 50, 22-22.
Marrelli A, Bombardieri M, Kelly S, Cipriani P, Giacomelli R, Pitzalis C (2011). DIGITAL IMAGE ANALYSIS FOR THE EVALUATION OF BLOOD VESSEL DENSITY IN RHEUMATOID SYNOVIUM: CORRELATION WITH QUANTITATIVE REAL-TIME PCR EXPRESSION OF ENDOTHELIAL ANTIGEN AND ANGIOGENIC GROWTH FACTORS. RHEUMATOLOGY. vol. 50, 75-75.
Croia C, Serafini B, Bombardieri M, Kelly S, Coccia EM, Severa M, Francesca A, Pitzalis C (2011). EBV INFECTION IN THE RHEUMATOID ARTHRITIS SYNOVIUM: RELATIONSHIP TO ECTOPIC LYMPHOID STRUCTURES AND CD8 T CELL ACTIVATION. RHEUMATOLOGY. vol. 50, 75-75.
Astorri E, Bombardi M, Peakman M, Pozzilli P, Pitzalis C (2011). EVOLUTION OF ECTOPIC LYMPHOID NEOGENESIS AND IN SITU AUTOANTIBODY PRODUCTION IN AUTOIMMUNE DIABETIC NOD MICE: CELLULAR AND MOLECULAR CHARACTERIZATION OF TERTIARY LYMPHOID STRUCTURES IN PANCREATIC ISLETS. RHEUMATOLOGY. vol. 50, 52-53.
Priori R, Barone F, Alessandri C, Colafrancesco S, McInnes IB, Pitzalis C, Valesini G, Bombardieri M(2011). Markedly increased IL-18 liver expression in adult-onset Still's disease-related hepatitis. Rheumatology (Oxford) vol. 50, (4) 776-780.
10.1093/rheumatology/keq397
Kurunadalingam H, Parwaiz I, Kumar K, Howlett K, Hands B, Raza K, Pitzalis C, Buckley C et al. (2011). THE SAFETY AND ACCEPTABILITY OF ULTRASOUND-GUIDED BIOPSY IN EARLY ARTHRITIS PATIENTS. RHEUMATOLOGY. vol. 50, 101-101.
Mahoney DJ, Swales C, Athanasou NA, Bombardieri M, Pitzalis C, Kliskey K, Sharif M, Day AJ et al.(2011). TSG-6 Inhibits Osteoclast Activity via an Autocrine Mechanism and Is Functionally Synergistic With Osteoprotegerin. ARTHRITIS RHEUM-US vol. 63, (4) 1034-1043.
10.1002/art.30201
Bugatti S, Manzo A, Vitolo B, Fusetti C, Humby F, Caporali R, Pitzalis C, Montecucco C (2011). B CELL DISTRIBUTION AND ACTIVATION-INDUCED CYTIDINE DEAMINASE EXPRESSION IN RHEUMATOID SYNOVITIS: CLINICAL AND BIO-MOLECULAR CORRELATES. ANNALS OF THE RHEUMATIC DISEASES. vol. 70, A55-A55.
10.1136/ard.2010.148999.4
El Shikh ME, El Sayed RM, Kmieciak M, Manjili M, Szakal A, Pitzalis C, Tew J (2011). BREAKAGE OF B CELL TOLERANCE BY ANTIGENS ON FOLLICULAR DENDRITIC CELLS. ANNALS OF THE RHEUMATIC DISEASES. vol. 70,
10.1136/ard.2010.148999.9
Astorri E, Bombardieri M, Gabba S, Peakman M, Pozzilli P, Pitzalis C (2011). EVOLUTION OF ECTOPIC LYMPHOID NEOGENESIS AND IN SITU AUTOANTIBODIES PRODUCTION IN AUTOIMMUNE DIABETIC NOD MICE: CELLULAR AND MOLECULAR CHARACTERISATION OF TERTIARY LYMPHOID STRUCTURES IN PANCREATIC ISLETS. ANNALS OF THE RHEUMATIC DISEASES. vol. 70,
10.1136/ard.2010.148999.2
de Sande MGHV, Gerlag DM, Lodde BM, van Baarsen LGM, Alivernini S, Codullo V, Felea I, Vieira-Sousa E et al.(2011). Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trials. ANN RHEUM DIS vol. 70, (3) 423-427.
10.1136/ard.2010.139550
Astorri E (2011). Interplay between inflammation, autoimmunity and regeneration in the NOD mouse model of type 1 diabetes and Sjogren’s syndrome. Supervisors: Pitzalis, C, Bombardieri, M,
Humby F (2011). The clinical and immunological significance of ectopic lymphoneogenesis within the rheumatoid synovial membrane. Supervisors: Pitzalis, C, Kirkham, B,
Pitzalis C(2011). THE ROLE OF SYNOVIAL BIOPSY IN THE DIAGNOSIS OF INFLAMMATORY ARTHRITIS. CLIN EXP RHEUMATOL vol. 29, (1) 154-154.
Ng W-F, Bowman SJ, Griffiths B, UKPSSR study group(2011). United Kingdom Primary Sjogren's Syndrome Registry--a united effort to tackle an orphan rheumatic disease. Rheumatology (Oxford) vol. 50, (1) 32-39.
10.1093/rheumatology/keq240
Patel HB, Bombardieri M, Sampaio ALF, D'Acquisto F, Gray M, Grieco P, Getting SJ, Pitzalis C et al.(2010). Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis. FASEB J vol. 24, (12) 4835-4843.
10.1096/fj.10-167759
Corsiero E, Bombardieri M, Humby F, Manzo A, Kelly S, Pitzalis C (2010). Characterization of inter follicular large B cells, a new subpopulation of B lymphocytes, in tertiary lymphoid organs in rheumatic autoimmune diseases. IMMUNOLOGY. vol. 131, 33-33.
Astorri E, Guglielmi C, Bombardieri M, Alessandri C, Buzzetti R, Maggi D, Valesini G, Pitzalis C et al.(2010). Circulating Reg1α proteins and autoantibodies to Reg1α proteins as biomarkers of β-cell regeneration and damage in type 1 diabetes. Horm Metab Res vol. 42, (13) 955-960.
10.1055/s-0030-1267206
Croia C, Serafini B, Bombardieri M, Kelly S, Coccia EM, Severa M, Aloisi F, Pitzalis C (2010). EBV infection in the rheumatoid arthritis synovium: relationship to tertiary lymphoid structures and CD8 T cell activation. IMMUNOLOGY. vol. 131, 124-124.
Astorri E, Bombardieri M, Gabba S, Peakman M, Pozzilli P, Pitzalis C (2010). Evolution of ectopic lymphoid neogenesis and in-situ autoantibodies production in autoimmune diabetic NOD mice: cellular and molecular characterization of tertiary lymphoid structures in pancreatic islet. IMMUNOLOGY. vol. 131, 63-63.
Lucchesi D, Astorri E, Bombardieri M, Corsiero E, Barone F, Proctor G, Pitzalis C (2010). Molecular and cellular evolution of functional tertiary lymphoid structures in salivary glands of NOD mice. IMMUNOLOGY. vol. 131, 59-59.
Kam NW, Bombardieri M, Brentano F, Choi K, Kyburz D, Gay S, Mclnnes IB, Pitzalis C (2010). Rheumatoid synovial fibroblasts support AID expression and Ig class-switching in B cells via a Baff-dependent TLR3-stimulated pathway. IMMUNOLOGY. vol. 131, 71-71.
Ciccia F, Bombardieri M, Rizzo A, Principato A, Giardina AR, Raiata F, Peralta S, Ferrante A et al.(2010). Over-expression of paneth cell-derived anti-microbial peptides in the gut of patients with ankylosing spondylitis and subclinical intestinal inflammation. Rheumatology (Oxford) vol. 49, (11) 2076-2083.
10.1093/rheumatology/keq239
Sherwood J, Key S, Achan P, Nalesso G, Pitzalis C, Dell'Accio F (2010). CXCR1 AND CXCR2 SIGNALLING IS REQUIRED BUT IS NOT SUFFICIENT TO MAINTAIN THE PHENOTYPIC STABILITY OF HUMAN ARTICULAR CHONDROCYTES. OSTEOARTHRITIS AND CARTILAGE. vol. 18, S96-S96.
10.1016/S1063-4584(10)60230-0
Nalesso G, Achan P, Pitzalis C, Dell'Accio F (2010). WNT3A MODULATES CHONDROCYTE PHENOTYPE THROUGH ACTIVATION OF BOTH CANONICAL AND NON-CANONICAL PATHWAYS. OSTEOARTHRITIS AND CARTILAGE. vol. 18, S104-S105.
10.1016/S1063-4584(10)60252-X
Astorri E, Bombardieri M, Gabba S, Peakman M, Pozzilli P, Pitzalis C(2010). Evolution of ectopic lymphoid neogenesis and in situ autoantibody production in autoimmune nonobese diabetic mice: cellular and molecular characterization of tertiary lymphoid structures in pancreatic islets. J Immunol vol. 185, (6) 3359-3368.
10.4049/jimmunol.1001836
Shirlaw P, Hullah E, Barone F, Panayi G, Kirkham B, Larkin G, Pitzalis C, Cook R et al.(2010). Changes in parameters of Sjogrens syndrome (SS) assessed after 10 years on a combined SS clinic. ORAL DIS vol. 16, (6) 539-539.
Connolly M, Marrelli A, Blades M, McCormick J, Maderna P, Godson C, Mullan R, FitzGerald O et al.(2010). Acute Serum Amyloid A Induces Migration, Angiogenesis, and Inflammation in Synovial Cells In Vitro and in a Human Rheumatoid Arthritis/SCID Mouse Chimera Model. J IMMUNOL vol. 184, (11) 6427-6437.
10.4049/jimmunol.0902941
Sherwood JC, Achan P, Ramachandran M, Pitzalis C, Dell'Accio F (2010). CXCR1/2 SIGNALLING IS REQUIRED FOR THE PHENOTYPIC STABILITY OF HUMAN ARTICULAR CHONDROCYTES. RHEUMATOLOGY. vol. 49, I13-I13.
Sherwood JC, Pitzalis C, Dell'Accio F (2010). CXCR1/2 signalling in the phenotypic stability of in vitro expanded adult human articular chondrocytes. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 91, A40-A40.
Nalesso G, Eltawil NM, Pitzalis C, Dell'Accio F (2010). Effects of the modulation of Wnt-canonical pathway on the phenotypic stability of human articular chondrocytes. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 91, A40-A41.
Astorri E, Bombardieri M, Corsiero E, Gabba S, Barone F, Proctor G, Pitzalis C (2010). MOLECULAR AND CELLULAR EVOLUTION OF FUNCTIONAL TERTIARY LYMPHOID STRUCTURES IN SALIVARY GLANDS OF NOD MICE. RHEUMATOLOGY. vol. 49, I28-I28.
10.1093/rheumatology/keq710
Eltawil N, Pitzalis C, Dell'Accio F (2010). Molecular response of articular cartilage to injury: Wnt signaling in an in vivo model of joint surface injury. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 91, A29-A29.
Bombardieri M, Kam YNW, Brentano F, Choi K, Kyburz D, Gay S, McInnes IB, Pitzalis C (2010). RHEUMATOID SYNOVIAL FIBROBLASTS SUPPORT AID EXPRESSION AND IG CLASS-SWITCHING IN B CELLS VIA A BAFF-DEPENDENT TLR3-STIMULATED PATHWAY. RHEUMATOLOGY. vol. 49, I26-I27.
Swales C, Mahoney DJ, Athanasou NA, Bombardieri M, Pitzalis C, Sharif O, Day AJ, Milner CM et al. (2010). TSG-6: AN AUTOCRINE REGULATOR OF INFLAMMATORY JOINT DISEASE?. RHEUMATOLOGY. vol. 49, I27-I27.
Ritchlin CT, Qureshi AA, de Vlam K, Pitzalis C, Helliwell PS, Mease PJ, Gladman DD, Krueger GG et al.(2010). Biomarkers in psoriasis and psoriatic arthritis: GRAPPA 2008. J Rheumatol vol. 37, (2) 462-467.
10.3899/jrheum.090957
Bombardieri M, Astorri E, Corsiero E, Gabba S, Barone F, Proctor G, Pitzalis C (2010). MOLECULAR AND CELLULAR EVOLUTION OF FUNCTIONAL TERTIARY LYMPHOID STRUCTURES IN SALIVARY GLANDS OF NOD MICE. ANNALS OF THE RHEUMATIC DISEASES. vol. 69,
10.1136/ard.2010.129585e
Burmester GR, Lipsky PE, Dörner T, Kitasato Meeting Faculty(2010). Kitasato Symposium 2010: new prospects for cytokines. Arthritis Res Ther vol. 12, (6)
10.1186/ar3196
Manzo A, Bombardieri M, Humby F, Pitzalis C(2010). Secondary and ectopic lymphoid tissue responses in rheumatoid arthritis: from inflammation to autoimmunity and tissue damage/remodeling. IMMUNOL REV vol. 233, 267-285.
10.1111/j.0105-2896.2009.00861.x
Duchene J, Cayla C, Vessillier S, Scotland R, Yamashiro K, Lecomte F, Syed I, Vo P et al.(2009). Laminar shear stress regulates endothelial kinin B1 receptor expression and function: potential implication in atherogenesis. Arterioscler Thromb Vasc Biol vol. 29, (11) 1757-1763.
10.1161/ATVBAHA.109.191775
Scheiermann C, Colom B, Meda P, Patel NSA, Voisin M-B, Marrelli A, Woodfin A, Pitzalis C et al.(2009). Junctional adhesion molecule-C mediates leukocyte infiltration in response to ischemia reperfusion injury. Arterioscler Thromb Vasc Biol vol. 29, (10) 1509-1515.
10.1161/ATVBAHA.109.187559
Macor P, Durigutto P, De Maso L, Cortini A, Garrovo C, Edomi P, Pitzalis C, Tedesco F (2009). Prevention of antigen-induced arthritis by targeting synovial endothelium with a neutralizing recombinant antibody to C5. MOLECULAR IMMUNOLOGY. vol. 46, 2837-2837.
10.1016/j.molimm.2009.05.239
Garrood T, Blades M, Haskard DO, Mather S, Pitzalis C(2009). A novel model for the pre-clinical imaging of inflamed human synovial vasculature. Rheumatology (Oxford) vol. 48, (8) 926-931.
10.1093/rheumatology/kep117
Robinson H, Kelly S, Pitzalis C (2009). Basic synovial biology and immunopathology in psoriatic arthritis. J Rheumatol Suppl. vol. 83, 14-16.
10.3899/jrheum.090212
Eltawil NM, De Bari C, Achan P, Pitzalis C, Dell'accio F(2009). A novel in vivo murine model of cartilage regeneration. Age and strain-dependent outcome after joint surface injury. Osteoarthritis Cartilage vol. 17, (6) 695-704.
10.1016/j.joca.2008.11.003
Evans HG, Gullick NJ, Kelly S, Pitzalis C, Lord GM, Kirkham BW, Taams LS(2009). In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses. Proc Natl Acad Sci U S A vol. 106, (15) 6232-6237.
10.1073/pnas.0808144106
Patel HB, Bombardieri M, Pitzalis C, Perretti M(2009). Activation of melanocortin receptor type 3 as a new strategy to control experimental and rheumatoid arthritis. EUR J CLIN INVEST vol. 39, 29-29.
Colom B, Scheiermann C, Woodfin A, Meda P, Patel N, Marrelli A, Pitzalis C, Thiemermann C et al.(2009). Effect of soluble JAM-C on leukocyte transmigration in models of ischemia/reperfusion injury. FASEB JOURNAL vol. 23,
Bombardieri M, Ciccia F, Principato A, Tripodo C, Peralta S, Triolo G, Pitzalis C (2009). IL-23 OVEREXPRESSION AS IMMUNOLOGICAL SIGNATURE OF SUBCLINICAL INTESTINAL INFLAMMATION IN ANKYLOSING SPONDYLITIS. RHEUMATOLOGY. vol. 48, I6-I6.
Ciccia F, Bombardieri M, Principato A, Giardina A, Tripodo C, Porcasi R, Peralta S, Franco V et al.(2009). Overexpression of Interleukin-23, but Not Interleukin-17, as an Immunologic Signature of Subdinical Intestinal Inflammation in Ankylosing Spondylitis. ARTHRITIS RHEUM vol. 60, (4) 955-965.
10.1002/art.24389
Garrood T, Lee L, Blades M, Kamperidis P, Pitzalis C (2009). TNF-ALPHA MODULATES TISSUE-SPECIFIC VASCULAR DETERMINANTS RECOGNIZED IN VIVO BY A PHAGE CLONE DISPLAYING A SYNOVIAL-HOMING PEPTIDE IN THE HUMAN/SCID MOUSE TRANSPLANTATION MODEL. RHEUMATOLOGY. vol. 48, I39-I39.
Conigliaro P, Priori R, Bombardieri M, Alessandri C, Barone F, Pitzalis C, McInnes IB, Valesini G(2009). Lymph node IL-18 expression in adult-onset Still's disease. Ann Rheum Dis vol. 68, (3) 442-443.
10.1136/ard.2008.093781
Dell'Accio F, Eltawil NM, De Bari C, Pitzalis C (2009). WNT16 in joint surface injury and osteoarthritis. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 90, A84-A84.
Kamperidis P (2009). Identification of Single-Chain Antibody Fragments Specific for Human Synovial Microvasclar Endothelium by In-Vivo Phage Display. Supervisors: Pitzalis, C, Nissim, A, George, A,
Humby F, Bombardieri M, Manzo A, Kelly S, Blades MC, Kirkham B, Spencer J, Pitzalis C(2009). Ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synovium. PLoS Med vol. 6, (1)
10.1371/journal.pmed.0060001
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6360
Evans HG, Gullick NJ, Kelly S, Pitzalis C, Lord GM, Kirkham BW, Taams LS (2008). Potent induction of Th17 cells by synovial monocytes from active rheumatoid arthritis patients. IMMUNOLOGY. vol. 125, 59-59.
Manzo A, Vitolo B, Humby F, Caporali R, Jarrossay D, Dell'Accio F, Ciardelli L, Uguccioni M et al.(2008). Mature Antigen-Experienced T Helper Cells Synthesize and Secrete the B Cell Chemoattractant CXCL13 in the Inflammatory Environment of the Rheumatoid Joint. ARTHRITIS RHEUM vol. 58, (11) 3377-3387.
10.1002/art.23966
El Tawil NM, De Bari C, Pitzalis C, Dell'Accio F (2008). A mouse model of joint surface injury and repair in mice. Age and strain-dependent outcome. ARTHRITIS AND RHEUMATISM. vol. 58, S647-S647.
Connolly M, McCormick J, Marelli A, Blades M, FitzGerald O, Bresnihan B, Pitzalis C, Veale D et al. (2008). A-SAA induces rho GTPase-dependent cytoskeletal rearrangement and in vivo migration of fluorochrome labelled monocytic (u937) cells in a human RA/SCID mice chimera model. ARTHRITIS AND RHEUMATISM. vol. 58, S627-S627.
Astorri E, Bombardieri M, Guglielmi C, Pitzalis C, Pozzilli P(2008). Beta cell regeneration in type 1 diabetes: the role of Reg genes in NOD mice. DIABETOLOGIA vol. 51, S186-S186.
Humby F, Bombardieri M, Antonio M, Blades M, Bruce K, Spencer J, Pitzalis C (2008). Ectopic lymphoid structures expressing AID drive self sustained in situ prodction of autoantibodies in rheumatoid synovium. ARTHRITIS AND RHEUMATISM. vol. 58, S633-S634.
Bugatti S, Manzo A, Caporali R, Scire CA, Vitolo B, Codullo V, Epis OM, Fusetti C et al. (2008). Lymphocyte organisation and lymphatic angiogenesis in rheumatoid synovitis: Clinical and radiographic correlates. ARTHRITIS AND RHEUMATISM. vol. 58, S767-S768.
Evans HG, Gullick NJ, Kelly S, Pitzalis C, Kirkham B, Taams LS (2008). Potent induction of Th17 cells by synovial monocytes from active rheumatoid arthritis patients. ARTHRITIS AND RHEUMATISM. vol. 58, S634-S634.
Evans HG, Gullick NJ, Kelly S, Pitzalis C, Lord GM, Kirkham BW, Taams LS (2008). Potent induction of th17 cells by synovial monocytes from active rheumatoid arthritis patients. ARTHRITIS AND RHEUMATISM. vol. 58, S165-S166.
Humby F, Gullick N, Kelly S, Pitzalis C, Oakley SP(2008). A synovial pathergy reaction leading to a pseudo-septic arthritis and a diagnosis of Behcet's disease. RHEUMATOLOGY vol. 47, (8) 1255-1256.
10.1093/rheumatology/ken194
Kelly S, Taylor P, Pitzalis C(2008). Ultrasound imaging in spondyloathropathies: from imaging to diagnostic intervention. Curr Opin Rheumatol vol. 20, (4) 408-415.
10.1097/BOR.0b013e328303e1ad
Choy EHS, Smith CM, Farewell V, Walker D, Hassell A, Chau L, Scott DL, CARDERA (Combination Anti-Rheumatic Drugs in Early Rheumatoid Arhritis) Trial Group(2008). Factorial randomised controlled trial of glucocorticoids and combination disease modifying drugs in early rheumatoid arthritis. Ann Rheum Dis vol. 67, (5) 656-663.
10.1136/ard.2007.076299
Dell'accio F, De Bari C, Eltawil NM, Vanhummelen P, Pitzalis C(2008). Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis. Arthritis Rheum vol. 58, (5) 1410-1421.
10.1002/art.23444
Bombardieri M, Barone F, Humby F, Morgan P, Challacombe S, Spencer J, Pitzalis C (2008). Activation-induced cytidine deaminase expression supports functionality of ectopic lymphoid neogenesis in patients with and animal models of Sjogren's syndrome. RHEUMATOLOGY. vol. 47, II85-II85.
Humby F, Bombardieri M, Manzo A, Blades M, Kirkham B, Spencer J, Pitzalis C (2008). Activation-induced cytidine deaminase supports self sustained autoantibody production within RA synovium. RHEUMATOLOGY. vol. 47, II59-II59.
Barone F, Bombardieri M, Rosado MM, Morgan PR, Challacombe SJ, De Vita S, Carsetti R, Spencer J et al.(2008). CXCL13, CCL21, and CXCL12 expression in salivary glands of patients with Sjogren's syndrome and MALT lymphoma: Association with reactive and malignant areas of lymphoid organization. J IMMUNOL vol. 180, (7) 5130-5140.
10.4049/jimmunol.180.7.5130
Garrood T, Blades M, Mather S, Haskard D, Pitzalis C (2008). Imaging E-selectin expression in human synovium in a scid mouse transplantation model. RHEUMATOLOGY. vol. 47, II55-II55.
Evans HG, Gullick NJ, Kelly S, Pitzalis C, Lord GM, Kirkham BW, Taams LS (2008). Potent induction of interleukin-17 producing CD4+ T cells (TH17 cells) by synovial monocytes from active RA patients. RHEUMATOLOGY. vol. 47, II59-II59.
Dell'Accio F, Eltawil NM, De Bari C, Pitzalis C (2008). Wnt16 in joint surface injury and osteoarthritis. RHEUMATOLOGY. vol. 47, II177-II178.
Bombardieri M, Barone F, Pitzalis C(2008). Response to comment on "Activation-Induced Cyridine Deaminase Expression in Follicular Dendritic Cell Networks and Interfollicular Large B Cells Supports Functionality of Ectopic Lymphoid Neogenesis in Autoimmune Sialoadenitis aud MALT Lymphoma in Sjogren's Syndrome". J IMMUNOL vol. 180, (4) 2008-2009.
10.4049/jimmunol.180.4.2008
De Bari C, Dell'Accio F, Karystinou A, Guillot PV, Fisk NM, Jones EA, McGonagle D, Khan IM et al.(2008). A biomarker-based mathematical model to predict bone-forming potency of human synovial and periosteal mesenchymal stem cells. Arthritis Rheum vol. 58, (1) 240-250.
10.1002/art.23143
Gerli R, Lunardi C, Bocci EB, Bobbio-Pallavicini F, Schillaci G, Caporali R, Bistoni O, Pirro M et al.(2008). Anti-tumor necrosis factor-alpha response in rheumatoid arthritis is associated with an increase in serum soluble CD30. J Rheumatol vol. 35, (1) 14-19.
Evans H, Gullick N, Kelly S, Pitzalis C, Lord G, Kirkham B, Taams L (2008). Potent induction of interleukin-17 producing CD4+T cells (Th17 cells) by synovial monocytes from active RA patients. CLINICAL IMMUNOLOGY. vol. 127, S20-S20.
10.1016/j.clim.2008.03.497
Manzo A (2008). Re-programming of the CXCL13-CCL21 Lymphoid Chemokine System in Ectopic Lymphoid Neogenesis during Chronic Arthritis. Supervisors: Pitzalis, C, Hayday, A,
Quartuccio L, Fabris M, Moretti M, Barone F, Bombardieri M, Rupolo M, Lombardi S, Pitzalis C et al.(2008). Resistance to rituximab therapy and local BAFF overexpression in Sjögren's syndrome-related myoepithelial sialadenitis and low-grade parotid B-cell lymphoma. Open Rheumatol J vol. 2, 38-43.
10.2174/1874312900802010038
Manzo A, Bugatti S, Caporali R, Prevo R, Jackson DG, Uguccioni M, Buckley CD, Montecucco C et al.(2007). CCL21 expression pattern of human secondary lymphoid organ stroma is conserved in inflammatory lesions with lymphoid neogenesis. AM J PATHOL vol. 171, (5) 1549-1562.
10.2353/ajpath.2007.061275
Manzo A, Pitzalis C(2007). Lymphoid tissue reactions in rheumatoid arthritis. Autoimmun Rev vol. 7, (1) 30-34.
10.1016/j.autrev.2007.03.006
Bombardieri M, Barone F, Humby F, Kelly S, McGurk M, Morgan P, Challacombe S, De Vita S et al.(2007). Activation-induced cytidine deaminase expression in follicular dendritic cell networks and interfollicular large B cells supports functionality of ectopic lymphoid neogenesis in autoimmune sialoadenitis and MALT lymphoma in Sjögren's syndrome. J Immunol vol. 179, (7) 4929-4938.
10.4049/jimmunol.179.7.4929
Brunton F, Lee L, Nissim A, Grigoriadis AE, Pitzalis C (2007). Targeting osteoclasts in rheumatoid arthritis via the alpha(v)beta(3) integrin. JOURNAL OF BONE AND MINERAL RESEARCH. vol. 22, 1113-1113.
Kamperidis PS, Lee L, Blades M, Garrood T, Nissim A, George A, Pitzalis C (2007). Identification of single-chain antibody fragments specific for human synovial microvascular endothelium by in vivo phage display. ANNALS OF THE RHEUMATIC DISEASES. vol. 66, A12-A13.
Brunton F, Lee L, Nissim A, Grigoriadis A, Pitzalis C (2007). Modulating osteoclast function by targeting the alphavbeta3 integrin. ANNALS OF THE RHEUMATIC DISEASES. vol. 66, A19-A19.
Humby F, Manzo A, Kirkham B, Pitzalis C(2007). The synovial membrane as a prognostic tool in rheumatoid arthritis. Autoimmun Rev vol. 6, (4) 248-252.
10.1016/j.autrev.2006.08.013
Barone F, Bombardieri M, Spencer J, Isaacson P, Humby F, Morgan P, Challacombe S, Valesini G et al.(2007). CXCL13, CCL21 and CXCL12 are upregulated in mucosal-associated lymphoid tissue lymphomas in patients with Sjorgen's syndrome and cooperate in the maintenance of the immune response and malignant cell survival. Arthritis research & therapy vol. 9, (Suppl 3) P15-P15.
10.1186/ar2241
Scire CA, Epis O, Codullo V, Humby F, Morbini P, Manzo A, Caporali R, Pitzalis C et al.(2007). Immunohistological assessment of the synovial tissue in small joints in rheumatoid arthritis: validation of a minimally invasive ultrasound-guided synovial biopsy procedure. ARTHRITIS RES THER vol. 9, (5) Article R101,
10.1186/ar2302
https://qmro.qmul.ac.uk/xmlui/handle/123456789/32323
Tyndall A, Walker UA, Cope A, Dazzi F, De Bari C, Fibbe W, Guiducci S, Jones S et al.(2007). Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005. Arthritis Res Ther vol. 9, (1)
10.1186/ar2103
Lee L, Garrood T, Pitzalis C(2007). In vivo phage display selection in the human/SCID mouse chimera model for defining synovial specific determinants. Methods Mol Med vol. 136, 369-394.
10.1007/978-1-59745-402-5_26
Bombardieri M, McInnes IB, Pitzalis C(2007). Interleukin-18 as a potential therapeutic target in chronic autoimmune/inflammatory conditions. Expert Opin Biol Ther vol. 7, (1) 31-40.
10.1517/14712598.7.1.31
DELL'ACCIO F, Pitzalis C, Barone F, Mitsiadis T, De Bari C(2006). Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury. Arthritis Research & Therapy vol. 8, (5) R139-R139.
10.1186/ar2029
https://qmro.qmul.ac.uk/xmlui/handle/123456789/18411
Filer A, Pitzalis C, Buckley CD(2006). Targeting the stromal microenvironment in chronic inflammation. Curr Opin Pharmacol vol. 6, (4) 393-400.
10.1016/j.coph.2006.03.007
Pitzalis C, Garrood T(2006). From ubiquitous antigens to joint-specific inflammation: could local vascular permeability be the missing link?. Trends Immunol vol. 27, (7) 299-302.
10.1016/j.it.2006.05.005
PITZALIS C, Barone F, Peakman M, Lozanoska-Ochser B(2006). Atorvastatin fails to prevent the development of autoimmune diabetes despite inhibition of pathogenic beta-cell-specific CD8 T-cells. Diabetes vol. 55, (4) 1004-1010.
10.2337/diabetes.55.04.06.db05-1261
De Bari C, Dell'Accio F, Vanlauwe J, Eyckmans J, Khan IM, Archer CW, Jones EA, McGonagle D et al.(2006). Mesenchymal multipotency of adult human periosteal cells demonstrated by single-cell lineage analysis. Arthritis Rheum vol. 54, (4) 1209-1221.
10.1002/art.21753
Garrood T, Pitzalis C(2006). Targeting the inflamed synovium: the quest for specificity. Arthritis Rheum vol. 54, (4) 1055-1060.
10.1002/art.21720
Garrood T, Lee L, Pitzalis C(2006). Molecular mechanisms of cell recruitment to inflammatory sites: general and tissue-specific pathways. Rheumatology (Oxford) vol. 45, (3) 250-260.
10.1093/rheumatology/kei207
De Bari C, Pitzalis C, Dell'Accio F(2006). Reparative medicine: from tissue engineering to joint surface regeneration. Regen Med vol. 1, (1) 59-69.
10.2217/17460751.1.1.59
Bugatti S, Caporali R, Manzo A, Vitolo B, Pitzalis C, Montecucco C(2005). Involvement of subchondral bone marrow in rheumatoid arthritis: lymphoid neogenesis and in situ relationship to subchondral bone marrow osteoclast recruitment. Arthritis Rheum vol. 52, (11) 3448-3459.
10.1002/art.21377
PITZALIS C, Manzo A, Bombardieri M, Valesini G, Challacombe SJ, Morgan PR, Barone F, Blades MC(2005). Association of CXCL13 and CCL21 Expression With the Progressive Organization of Lymphoid-like Structures in Sjogren’s Syndrome. Arthritis & Rheumatism vol. 52, (6) 1773-1784.
10.1002/art.21062
PITZALIS C, Manzo A, Uguccioni M, Caporali R, Bresnihan B, Blades MC, Barone F, Yanni G et al.(2005). Systematic microanatomical analysis of CXCL13 and CCL21 in situ production and progressive lymphoid organization in rheumatoid synovitis. Eur J Immunol vol. 35, 1347-1359.
10.1002/eji.200425830
Keeble J, Blades M, Pitzalis C, Castro da Rocha FA, Brain SD(2005). The role of substance P in microvascular responses in murine joint inflammation. Br J Pharmacol vol. 144, (8) 1059-1066.
10.1038/sj.bjp.0706131
Manzo A, Bugatti S, Buckley C, Jackson D, Caporali R, Montecucco C, Pitzalis C(2005). CCL21 relationship with lymphoid neogenesis and lymphatic vascular system in chronically inflamed synovium. Arthritis research & therapy vol. 7, (Suppl 1) P139-P139.
10.1186/ar1660
De Bari C, Dell'Accio F, Vanlauwe J, Pitzalis C, Luyten FP(2005). Distinct biological properties of human mesenchymal stem cells from different sources. Arthritis research & therapy vol. 7, (Suppl 1) P107-P107.
10.1186/ar1628
Bombardieri M, Barone F, Proctor G, van de Loo FA, van den Berg WB, Valesini G, McInnes IB, Pitzalis C(2005). Efficient IL-18 and IL-18BPc adenoviral gene transfer to cultured murine submandibular gland epithelial cells and successful murine retrograde submandibular duct cannulation to modulate IL-18 function in the salivary gland of animal models of Sjogren's syndrome. Arthritis research & therapy vol. 7, (Suppl 1) P94-P94.
10.1186/ar1615
Dell'Accio F, De Bari C, Pitzalis C(2005). Molecular response to cartilage injury. Arthritis research & therapy vol. 7, (Suppl 1) P131-P131.
10.1186/ar1652
Pipitone N, Pitzalis C(2004). [Arthritides in the elderly]. Recenti Prog Med vol. 95, (9) 432-442.
Pipitone N, Pitzalis C(2004). Recent advances in the treatment of psoriatic arthritis. Expert Opin Ther Pat vol. 14, (4) 509-525.
10.1517/13543776.14.4.509
Bombardieri M, Barone F, Pittoni V, Alessandri C, Conigliaro P, Blades MC, Priori R, McInnes IB et al.(2004). Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjögren's syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate. Arthritis Res Ther vol. 6, (5) R447-R456.
10.1186/ar1209
Barone F, Bombardieri M, Blades MC, Manzo A, Morgan P, Challacombe S, Valesini G, Pitzalis C(2004). Lymphoid chemokine expression in Sjogren's syndrome: relationship with the lymphoid organization of the periductal inflammatory aggregates. Arthritis research & therapy vol. 6, (Suppl 3) 94-94.
10.1186/ar1409
Pipitone N, Kingsley GH, Manzo A, Scott DL, Pitzalis C(2003). Current concepts and new developments in the treatment of psoriatic arthritis. Rheumatology (Oxford) vol. 42, (10) 1138-1148.
10.1093/rheumatology/keg363
De Benedetti F, Pignatti P, Biffi M, Bono E, Wahid S, Ingegnoli F, Chang S-YP, Alexander H et al.(2003). Increased expression of alpha(1,3)-fucosyltransferase-VII and P-selectin binding of synovial fluid T cells in juvenile idiopathic arthritis. J Rheumatol vol. 30, (7) 1611-1615.
Manzo A, Caporali R, Montecucco C, Pitzalis C(2003). Role of chemokines and chemokine receptors in regulating specific leukocyte trafficking in the immune/inflammatory response. Clin Exp Rheumatol vol. 21, (4) 501-508.
George AJT, Lee L, Pitzalis C(2003). Isolating ligands specific for human vasculature using in vivo phage selection. Trends Biotechnol vol. 21, (5) 199-203.
10.1016/S0167-7799(03)00079-9
Manzo A, Carulli M, Paoletti S, Blades M, Barone F, Yanni G, Caporali R, Montecucco C et al.(2003). BCA-1 (CXCL13) and SLC (CCL21) production and lymphoid neogenesis in rheumatoid synovitis. Arthritis research & therapy vol. 5, (Suppl 1) 105-105.
10.1186/ar735
Barone F, Blades M, Manzo A, Morgan P, Montecucco M, Valesini G, Pitzalis C(2003). CXCL13 and CCL21 play a key role in ectopic lymphoneogenesis in Sjögren's syndrome. Arthritis research & therapy vol. 5, (Suppl 1) 92-92.
10.1186/ar722
Lee L, Buckley C, Blades M, Panayi G, George AJ, Pitzalis C(2003). Identification of homing peptides specific for human synovium by phage display selection. Arthritis research & therapy vol. 5, (Suppl 1) 103-103.
10.1186/ar733
Pitzalis C, Manzo A, Paoletti S, Barone F, Caporali R, Montecucco CM, Uguccioni M(2003). Lymphoid neogenesis in chronic inflammation. Arthritis research & therapy vol. 5, (Suppl 3) 116-116.
10.1186/ar917
Gerli R, Lunardi C, Pitzalis C(2002). Unmasking the anti-inflammatory cytokine response in rheumatoid synovitis. Rheumatology (Oxford) vol. 41, (12) 1341-1345.
10.1093/rheumatology/41.12.1341
Gerli R, Pitzalis C, Lunardi C(2002). The role of T cell cytokines in modulating joint inflammation in rheumatoid arthritis. Isr Med Assoc J vol. 4, (11 Suppl) 949-952.
Perretti M, Ingegnoli F, Wheller SK, Blades MC, Solito E, Pitzalis C(2002). Annexin 1 modulates monocyte-endothelial cell interaction in vitro and cell migration in vivo in the human SCID mouse transplantation model. J Immunol vol. 169, (4) 2085-2092.
10.4049/jimmunol.169.4.2085
PITZALIS C, Lee L, Panayi G, Buckley C, Blades MC(2002). Identification of Synovium-Specific Homing Peptides by In Vivo Phage Display Selection. Arthritis & Rheumatism vol. 46, (8) 2109-2120.
10.1002/art.10464
Blades MC, Manzo A, Ingegnoli F, Taylor PR, Panayi GS, Irjala H, Jalkanen S, Haskard DO et al.(2002). Stromal cell-derived factor 1 (CXCL12) induces human cell migration into human lymph nodes transplanted into SCID mice. J IMMUNOL vol. 168, (9) 4308-4317.
10.4049/jimmunol.168.9.4308
Perretti M, Blades MC, Wheller SK, Wahid S, Solito E, Pitzalis C (2002). Monocytic cells over-expressing annexin 1 have reduced transmigration in vitro and elicitation in vivo. FASEB J. vol. 16, A598-A598.
Blades MC, Ingegnoli F, Wheller SK, Manzo A, Wahid S, Panayi GS, Perretti M, Pitzalis C(2002). Stromal cell-derived factor 1 (CXCL12) induces monocyte migration into human synovium transplanted onto SCID mice. ARTHRITIS RHEUM vol. 46, (3) 824-836.
10.1002/art.10102
Matsuno H, Yudoh K, Katayama R, Nakazawa F, Uzuki M, Sawai T, Yonezawa T, Saeki Y et al.(2002). The role of TNF-alpha in the pathogenesis of inflammation and joint destruction in rheumatoid arthritis (RA): a study using a human RA/SCID mouse chimera. Rheumatology (Oxford) vol. 41, (3) 329-337.
10.1093/rheumatology/41.3.329
Lee L, Buckley C, Blades MC, Panayi G, George AJT, Pitzalis C(2002). Identification of homing peptides specific for synovial microvascular endothelium using phage display selection. Arthritis research vol. 4, (Suppl 1) 33-33.
10.1186/ar474
Pitzalis C, Pipitone N, Perretti M (2002). Regulation of leukocyte-endothelial interactions by glucocorticoids. NEUROENDOCRINE IMMUNE BASIS OF THE RHEUMATIC DISEASES II, PROCEEDINGS. Editors: Cutolo, M, Bijlsma, JWJ, Lahita, RG, Masi, AT et al., vol. 966, 108-118.
10.1111/j.1749-6632.2002.tb04208.x
Ingegnoli F, Blades M, Manzo A, Wahid S, Perretti M, Panayi G, Pitzalis C(2002). Role of cell migration in the pathogenesis of rheumatoid arthritis: in vivo studies in SCID mice transplanted with human synovial membrane. Reumatismo vol. 54, (2) 128-132.
10.4081/reumatismo.2002.128
Blades MC, Manzo A, Ingegnoli F, Taylor P, Irjala H, Jalkanen S, Haskard DO, Perretti M et al. (2002). Stromal cell derived factor-1 (CXCL12) induces cell migration into lymph nodes transplanted into SCID MICE. An investigation of lymphocyte migration to secondary lymphoid organs. Arthritis research. vol. 4, 32-32.
10.1186/ar473
Ingegnoli F, Manzo A, Fantini F, Caporali R, Montecucco C, Pipitone N, Pitzalis C(2002). [Role of chemokines in the pathogenesis of chronic synovitis during rheumatoid arthritis]. Reumatismo vol. 54, (1) 12-18.
10.4081/reumatismo.2002.12
Pipitone N, Sinha M, Theodoridis E, Goulding N, Hall M, Lanchbury J, Corrigall V, Panayi G et al.(2001). The glucocorticoid inhibition of LFA-1 and CD2 expression by human mononuclear cells is reversed by IL-2, IL-7 and IL-15. EUR J IMMUNOL vol. 31, (7) 2135-2142.
10.1002/1521-4141(200107)31:7<2135::aid-immu2135>3.0.co;2-s
Pipitone N, Pipitone V, Pitzalis C(2001). [Glucocorticoids at the threshold of the new millennium: recent findings on the anti-inflammatory and immunomodulator mechanisms of action and future perspectives]. Ann Ital Med Int vol. 16, (3) 141-154.
Panayi GS, Corrigall VM, Pitzalis C(2001). Pathogenesis of rheumatoid arthritis. The role of T cells and other beasts. Rheum Dis Clin North Am vol. 27, (2) 317-334.
10.1016/s0889-857x(05)70204-0
Pitzalis C, Pipitone N, Pipitone V, Fioravanti A, Marcolongo R(2001). [Rheumatoid arthritis. Recent findings and new pathogenic concepts]. Recenti Prog Med vol. 92, (3) 217-222.
Gerli R, Lunardi C, Vinante F, Bistoni O, Pizzolo G, Pitzalis C(2001). Role of CD30+ T cells in rheumatoid arthritis: a counter-regulatory paradigm for Th1-driven diseases. Trends Immunol vol. 22, (2) 72-77.
10.1016/s1471-4906(00)01829-9
Pipitone N, Fioravanti A, Marcolongo R, Pitzalis C(2001). [Articular involvement in the course of primary hypogammaglobulinemia]. Recenti Prog Med vol. 92, (1) 63-67.
Pitzalis C(2001). selection of synovial specific targets using phage display technology. Arthritis research vol. 3, (Suppl 1) P6-P6.
10.1186/ar372
Huizinga TW, Keijsers V, Yanni G, Hall M, Ramage W, Lanchbury J, Pitzalis C, Drossaers-Bakker WK et al.(2000). Are differences in interleukin 10 production associated with joint damage?. Rheumatology (Oxford) vol. 39, (11) 1180-1188.
10.1093/rheumatology/39.11.1180
Pipitone N, Jolliffe VA, Cauli A, Scott DG, Pitzalis C(2000). Do B cells influence disease progression in chronic synovitis? Lessons from primary hypogammaglobulinaemia. Rheumatology (Oxford) vol. 39, (11) 1280-1285.
10.1093/rheumatology/39.11.1280
Pitzalis C, Koch A(2000). The vascular endothelial system in the pathogenesis of inflammation and systemic rheumatic diseases: relation to the neuroendocrine system. Rheum Dis Clin North Am vol. 26, (4) 765-773.
10.1016/s0889-857x(05)70168-x
Wahid S, Blades MC, De Lord D, Brown I, Blake G, Yanni G, Haskard DO, Panayi GS et al.(2000). Tumour necrosis factor-alpha (TNF-alpha) enhances lymphocyte migration into rheumatoid synovial tissue transplanted into severe combined immunodeficient (SCID) mice. Clin Exp Immunol vol. 122, (1) 133-142.
10.1046/j.1365-2249.2000.01342.x
Pitzalis C, Pipitone N(2000). Psoriatic arthritis. J R Soc Med vol. 93, (8) 412-415.
10.1177/014107680009300806
Cauli A, Pitzalis C, Yanni G, Awad M, Panayi GS(2000). CD1 expression in psoriatic and rheumatoid arthritis. Rheumatology (Oxford) vol. 39, (6) 666-673.
10.1093/rheumatology/39.6.666
Gerli R, Pitzalis C, Bistoni O, Falini B, Costantini V, Russano A, Lunardi C(2000). CD30+ T cells in rheumatoid synovitis: mechanisms of recruitment and functional role. J Immunol vol. 164, (8) 4399-4407.
10.4049/jimmunol.164.8.4399
Gerli R, Bistoni O, Lunardi C, Giacomelli R, Tomassini C, Biagini P, Pitzalis C(1999). Soluble CD30 in early rheumatoid arthritis as a predictor of good response to second-line therapy. Rheumatology (Oxford) vol. 38, (12) 1282-1284.
10.1093/rheumatology/38.12.1282
Goulding NJ, Ogbourn S, Pipitone N, Biagini P, Gerli R, Pitzalis C(1999). The inhibitory effect of dexamethasone on lymphocyte adhesion molecule expression and intercellular aggregation is not mediated by lipocortin 1. Clin Exp Immunol vol. 118, (3) 376-383.
10.1046/j.1365-2249.1999.01059.x
Masi AT, Bijlsma JW, Chikanza IC, Pitzalis C, Cutolo M(1999). Neuroendocrine, immunologic, and microvascular systems interactions in rheumatoid arthritis: physiopathogenetic and therapeutic perspectives. Semin Arthritis Rheum vol. 29, (2) 65-81.
10.1016/s0049-0172(99)80039-0
Perretti M, Wheller SK, Flower RJ, Wahid S, Pitzalis C(1999). Modulation of cellular annexin I in human leukocytes infiltrating DTH skin reactions. Journal of Leukocyte Biology vol. 65, (5) 583-589.
10.1002/jlb.65.5.583
Howie D, Spencer J, DeLord D, Pitzalis C, Wathen NC, Dogan A, Akbar A, MacDonald TT(1998). Extrathymic T cell differentiation in the human intestine early in life. J Immunol vol. 161, (11) 5862-5872.
Choy EH, Schantz A, Pitzalis C, Kingsley GH, Panayi GS(1998). The pharmacokinetics and human anti-mouse antibody response in rheumatoid arthritis patients treated with a chimeric anti-CD4 monoclonal antibody. Br J Rheumatol vol. 37, (7) 801-802.
10.1093/rheumatology/37.7.801
Pitzalis C(1998). Skin and joint disease in psoriatic arthritis: what is the link?. Br J Rheumatol vol. 37, (5) 480-483.
10.1093/rheumatology/37.5.480
Pitzalis C, Choy E (1998). Fourth International Symposium on the Immunotherapy of the Rheumatic Diseases. 21-25 May 1997, Cyprus. Ann Rheum Dis. vol. 57,
Pitzalis C, Pipitone N, Bajocchi G, Hall M, Goulding N, Lee A, Kingsley G, Lanchbury J et al.(1997). Corticosteroids inhibit lymphocyte binding to endothelium and intercellular adhesion: an additional mechanism for their anti-inflammatory and immunosuppressive effect. J Immunol vol. 158, (10) 5007-5016.
Pitzalis C, Sharrack B, Gray IA, Lee A, Hughes RA(1997). Comparison of the effects of oral versus intravenous methylprednisolone regimens on peripheral blood T lymphocyte adhesion molecule expression, T cell subsets distribution and TNF alpha concentrations in multiple sclerosis. J Neuroimmunol vol. 74, (1-2) 62-68.
10.1016/s0165-5728(96)00206-8
Pitzalis C, Pipitone N, Marcolongo R, Galeazzi M(1997). [Monoclonal antibody therapy]. Recenti Prog Med vol. 88, (3) 128-133.
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