Publications: Dr Gareth Pryce
Licht-Mayer S, Campbell GR, Mehta AR, McGill K, Symonds A, Al-Azki S, Pryce G, Zandee S et al.
(
2022
)
.
Axonal response of mitochondria to demyelination and complex IV activity within demyelinated axons in experimental models of multiple sclerosis
.
Neuropathology and Applied Neurobiology
Marta M, Baker D, Creeke P, Pryce G, Gnanapavan S, Giovannoni G
(
2021
)
.
Antigen-specific tolerization in human autoimmunity: Inhibition of interferon-beta1a anti-drug antibodies in multiple sclerosis: A case report
.
Multiple Sclerosis and Related Disorders
vol.
56
,
Baker D, Roberts CAK, Pryce G, Kang AS, Marta M, Reyes S, Schmierer K, Giovannoni G et al.
(
2020
)
.
COVID-19 vaccine-readiness for anti-CD20-depleting therapy in autoimmune diseases
.
Clinical and Experimental Immunology
vol.
202
,
(
2
)
149
-
161
.
Saxena G, Moore JM, Jones M, Pryce G, Ali L, Leisegang GR, Vijay V, Loveless S et al.
(
2020
)
.
Detecting and predicting neutralization of alemtuzumab responses in MS
.
Neurology(R) neuroimmunology & neuroinflammation
vol.
7
,
(
4
)
Baker D
(
2020
)
.
Enhanced axonal response of mitochondria to demyelination offers neuroprotection: implications for multiple sclerosis
.
Acta Neuropathologica
Baker D, Pryce G, James LK, Marta M, Schmierer K
(
2020
)
.
The ocrelizumab phase II extension trial suggests the potential to improve the risk:benefit balance in multiple sclerosis
.
Multiple Sclerosis and Related Disorders
Article
102279
,
102279
-
102279
.
Baker D, Ali L, SAXENA G, Pryce G, Jones M, Schmierer K, Giovannoni G, Gnanapavan S et al.
(
2020
)
.
The irony of humanization: Alemtuzumab the first, but one of the most immunogenic, humanized monoclonal antibodies
.
Frontiers in Immunology
vol.
11
,
(
124
)
Baker D, Pryce G, James LK, Schmierer K, Giovannoni G
(
2020
)
.
Failed B cell survival factor trials support the importance of memory B cells in multiple sclerosis
.
European Journal of Neurology
vol.
27
,
(
2
)
221
-
228
.
Baker D, Pryce G, James LK, Marta M, Schmierer K
(
2020
)
.
The ocrelizumab phase II extension trial suggests the potential to improve the risk:benefit balance in multiple sclerosis
.
Multiple Sclerosis and Related Disorders2020.01.09.20016774
-
2020.01.09.20016774
.
Baker D, Pryce G, Herrod SS, Schmierer K
(
2019
)
.
Potential mechanisms of action related to the efficacy and safety of cladribine
.
Multiple Sclerosis and Related Disorders
vol.
30
,
176
-
186
.
Pryce G, Baker D
(
2019
)
.
CHAPTER 11 Cannabinoids as a Therapeutic Approach in Multiple Sclerosis
.
Emerging Drugs and Targets for Multiple Sclerosis
,
Pryce G, Baker D
(
2019
)
.
CHAPTER 11: Cannabinoids as a Therapeutic Approach in Multiple Sclerosis
.
RSC Drug Discovery Series
,
vol.
2019-January
,
BAKER D, GIOVANNONI G, PRYCE G, AMOR S, SCHMIERER K
(
2018
)
.
Learning from other autoimmunities to understand targeting of B cells to control multiple sclerosis
.
Brain
BO XUENONG, GUSHCHINA S, PRYCE G, YIP P, WU D, PALLIER P, GIOVANNONI G, BAKER D
(
2018
)
.
Increased expression of colony‐stimulating factor‐1 in mouse spinal cord with experimental autoimmune encephalomyelitis correlates with microglial activation and neuronal loss
.
Glia
vol.
66
,
(
10
)
2108
-
2125
.
BAKER D, Pryce, G
(
2018
)
.
Oligoclonal bands in multiple sclerosis; functional significance and therapeutic implications. Does the specificity matter?
.
multiple sclerosis and related disorders
Dubuisson N, Baker D, Kang AS, Pryce G, Marta M, Visser LH, Hofmann WE, Gnanapavan S et al.
(
2018
)
.
Alemtuzumab depletion failure can occur in multiple sclerosis
.
Immunology
vol.
154
,
(
2
)
253
-
260
.
Schmierer K, Marta M, Pryce G, Giovannoni G, Baker D
(
2017
)
.
PO150 Memory b cells are key for immunotherapy in multiple sclerosis
.
Journal of Neurology Neurosurgery & Psychiatry
.
vol.
88
,
a52
-
a52
.
Pryce G, Baker D
(
2017
)
.
Antidote to cannabinoid intoxication: the CB<inf>1</inf> receptor inverse agonist, AM251, reverses hypothermic effects of the CB<inf>1</inf> receptor agonist, CB-13, in mice
.
British Journal of Pharmacology
vol.
174
,
(
21
)
3790
-
3794
.
Pryce G, Sisay S, Petrova N, Giovannonni G, Selwood DL, Baker D
(
2017
)
.
Neuroprotection in an experimental model of multiple sclerosis, via opening of big conductance, calcium-activated potassium channels
.
MULTIPLE SCLEROSIS JOURNAL
.
vol.
23
,
621
-
622
.
BAKER D
(
2017
)
.
Big conductance calcium-activated potassium channel openers control spasticity without sedation
.
British Journal of Pharmcology
BAKER D, Giovannoni G, Sefia E, Pryce G, Meier U
(
2017
)
.
Depletion of CD20 B cells fails to inhibit relapsing mouse experimental autoimmune encephalomyelitis
.
Multiple Sclerosis and Related Disorders
von Kutzleben S, Pryce G, Giovannoni G, Baker D
(
2017
)
.
Depletion of CD52-positive cells inhibits the development of central nervous system autoimmune disease, but deletes an immunetolerance promoting CD8 t-cell population. Implications for secondary autoimmunity of alemtuzumab in multiple sclerosis
.
Immunology
vol.
150
,
(
4
)
444
-
455
.
Baker D, Marta M, Pryce G, Giovannoni G, Schmierer K
(
2017
)
.
Memory B Cells are Major Targets for Effective Immunotherapy in Relapsing Multiple Sclerosis
.
EBioMedicine
vol.
16
,
41
-
50
.
Williams T, Pryce G, Giovannoni G, Selwood D, Baker D
(
2016
)
.
VSN16R-A NOVEL TREATMENT FOR SPASTICITY IN EXPERIMENTAL MULTIPLE SCLEROSIS
.
vol.
87
,
is.
12
,
Abstract:
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,
Peferoen LAN, Breur M, van de Berg S, Peferoen-Baert R, Boddeke EHWGM, van der Valk P, Pryce G, van Noort JM et al.
(
2016
)
.
Ageing and recurrent episodes of neuroinflammation promote progressive experimental autoimmune encephalomyelitis in Biozzi ABH mice
.
Immunology
vol.
149
,
(
2
)
146
-
156
.
Sevastou I, Pryce G, Baker D, Selwood DL
(
2016
)
.
Characterisation of Transcriptional Changes in the Spinal Cord of the Progressive Experimental Autoimmune Encephalomyelitis Biozzi ABH Mouse Model by RNA Sequencing
.
PLOS ONE
vol.
11
,
(
6
)
e0157754
-
e0157754
.
Ummenthum K, Peferoen LAN, Finardi A, Baker D, Pryce G, Mantovani A, Bsibsi M, Bottazzi B et al.
(
2016
)
.
Pentraxin-3 is upregulated in the central nervous system during MS and EAE, but does not modulate experimental neurological disease
.
European Journal of Immunology
vol.
46
,
(
3
)
701
-
711
.
Warne J, Pryce G, Hill JM, Shi X, Lennerås F, Puentes F, Kip M, Hilditch L et al.
(
2016
)
.
Selective inhibition of the mitochondrial permeability transition pore protects against neurodegeneration in experimental multiple sclerosis
.
Journal of Biological Chemistry
vol.
291
,
(
9
)
4356
-
4373
.
Pryce G, Riddall DR, Selwood DL, Giovannoni G, Baker D
(
2015
)
.
Neuroprotection in Experimental Autoimmune Encephalomyelitis and Progressive Multiple Sclerosis by Cannabis-Based Cannabinoids
.
Journal of Neuroimmune Pharmacology
vol.
10
,
(
2
)
281
-
292
.
Pryce G, Baker D
(
2015
)
.
Endocannabinoids in multiple sclerosis and amyotrophic lateral sclerosis
.
vol.
231
,
213
-
231
.
Pryce G, Baker D
(
2015
)
.
Cannabinoids fail to show evidence of slowing down the progression of multiple sclerosis
.
Evidence-Based Medicine
vol.
20
,
(
4
)
Vainchtein I, Vinet J, Al-Izki S, Pryce G, Grit C, Brouwer N, Amor S, Baker D et al.
(
2015
)
.
Microglia are involved in apoptotic clearance during chronic-relapsing EAE
.
GLIA
.
vol.
63
,
E353
-
E353
.
Wu D, Cerutti C, Lopez-Ramirez MA, Pryce G, King-Robson J, Simpson JE, Van Der Pol SMA, Hirst MC et al.
(
2015
)
.
Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation
.
Journal of Cerebral Blood Flow and Metabolism
vol.
35
,
(
3
)
412
-
423
.
Pryce G, Riddall DR, Selwood DL, Giovannoni G, Baker D
(
2014
)
.
Neuroprotection in Experimental Autoimmune Encephalomyelitis and Progressive Multiple Sclerosis by Cannabis-Based Cannabinoids
.
Journal of Neuroimmune Pharmacology
Von Kutzleben S, Pryce G, Chretien N, Turner M, Siders W, Baker D
(
2014
)
.
Inhibition of relapsing experimental autoimmune encephalomyelitis in Biozzi ABH mice using a mouse CD52-specific monoclonal antibody
.
Journal of Neuroimmunology
.
vol.
275
,
Lopez-Ramirez MA, Wu D, Pryce G, Simpson JE, Reijerkerk A, King-Robson J, Kay O, de Vries HE et al.
(
2014
)
.
MicroRNA-155 negatively affects blood-brain barrier function during neuroinflammation
.
FASEB J
vol.
28
,
(
6
)
2551
-
2565
.
Hampton DW, Serio A, Pryce G, Al-Izki S, Franklin RJM, Giovannoni G, Baker D, Chandran S
(
2014
)
.
Neurodegeneration progresses despite complete elimination of clinical relapses in a mouse model of multiple sclerosis
.
Acta Neuropathologica Communications
vol.
2
,
(
1
)
Pryce G, Visintin C, Ramagopalan SV, Al-Izki S, De Faveri LE, Nuamah RA, Mein CA, Montpetit A et al.
(
2014
)
.
Control of spasticity in a multiple sclerosis model using central nervous system-excluded CB1 cannabinoid receptor agonists
.
FASEB J
vol.
28
,
(
1
)
117
-
130
.
Mullen L, Rigby A, Sclanders M, Adams G, Mittal G, Colston J, Fatah R, Subang C et al.
(
2014
)
.
Latency can be conferred to a variety of cytokines by fusion with latency-associated peptide from TGF-β
.
Expert Opin Drug Deliv
vol.
11
,
(
1
)
5
-
16
.
Al-Izki S, Pryce G, Hankey DJR, Lidster K, von Kutzleben SM, Browne L, Clutterbuck L, Posada C et al.
(
2014
)
.
Lesional-targeting of neuroprotection to the inflammatory penumbra in experimental multiple sclerosis
.
Brain
vol.
137
,
(
Pt 1
)
92
-
108
.
Pryce G, Cabranes A, Fernández-Ruiz J, Bisogno T, Di Marzo V, Long JZ, Cravatt BF, Giovannoni G et al.
(
2013
)
.
Control of experimental spasticity by targeting the degradation of endocannabinoids using selective fatty acid amide hydrolase inhibitors
.
Mult Scler
vol.
19
,
(
14
)
1896
-
1904
.
Puentes F, van der Star BJ, Victor M, Kipp M, Beyer C, Peferoen-Baert R, Ummenthum K, Pryce G et al.
(
2013
)
.
Characterization of immune response to neurofilament light in experimental autoimmune encephalomyelitis
.
Journal of Neuroinflammation
vol.
10
,
Baker D, Lidster K, Al-Izki S, Pryce G, Giovannoni G
(
2013
)
.
Animal models of progressive disability in MS
.
IRISH JOURNAL OF MEDICAL SCIENCE
vol.
182
,
S5
-
S6
.
Sisay S, Pryce G, Jackson SJ, Tanner C, Ross RA, Michael GJ, Selwood DL, Giovannoni G et al.
(
2013
)
.
Genetic background can result in a marked or minimal effect of gene knockout (GPR55 and CB2 receptor) in experimental autoimmune encephalomyelitis models of multiple sclerosis
.
PLoS One
vol.
8
,
(
10
)
Lopez-Ramirez MA, Wu D, Pryce G, Simpson JE, Reijerkerk A, King-Robson J, de Vries HE, Hirst MC et al.
(
2012
)
.
Endothelial miR-155 promotes blood brain barrier dysfunction in neuroinflammation
.
JOURNAL OF NEUROIMMUNOLOGY
.
vol.
253
,
3
-
4
.
Pryce G, Baker D
(
2012
)
.
Potential control of multiple sclerosis by cannabis and the endocannabinoid system
.
CNS Neurol Disord Drug Targets
vol.
11
,
(
5
)
624
-
641
.
Gnanapavan S, Grant D, Pryce G, Jackson S, Baker D, Giovannoni G
(
2012
)
.
Neurofilament a biomarker of neurodegeneration in autoimmune encephalomyelitis
.
Autoimmunity
vol.
45
,
(
4
)
298
-
303
.
Baker D, Pryce G, Jackson SJ, Bolton C, Giovannoni G
(
2012
)
.
The biology that underpins the therapeutic potential of cannabis-based medicines for the control of spasticity in multiple sclerosis
.
Multiple Sclerosis and Related Disorders
vol.
1
,
(
2
)
64
-
75
.
Hilliard A, Stott C, Wright S, Guy G, Pryce G, Al-Izki S, Bolton C, Giovannoni G
(
2012
)
.
Evaluation of the Effects of Sativex (THC BDS: CBD BDS) on Inhibition of Spasticity in a Chronic Relapsing Experimental Allergic Autoimmune Encephalomyelitis: A Model of Multiple Sclerosis
.
ISRN Neurol
vol.
2012
,
Al-Izki S, Pryce G, O'Neill JK, Butter C, Giovannoni G, Amor S, Baker D
(
2012
)
.
Practical guide to the induction of relapsing progressive experimental autoimmune encephalomyelitis in the Biozzi ABH mouse
.
Multiple Sclerosis and Related Disorders
vol.
1
,
(
1
)
29
-
38
.
Graves RS, Pryce G, Cabranes A, Fernandez-Ruiz J, Bisogno T, Di Marzo V, Cravatt BF, Michael GJ et al.
(
2011
)
.
Fatty acid amide hydrolase as a target for neuroprotection
.
MULTIPLE SCLEROSIS JOURNAL
vol.
17
,
S431
-
S431
.
Al-Izki S, Pryce G, Amor S, Gerritsen W, Garthwaite J, Giovannoni G, Selwood DL, Baker D
(
2011
)
.
Selective targeting of neuroprotection to MS lesions: sodium channel blockers in experimental autoimmune encephalomyelitis
.
MULTIPLE SCLEROSIS JOURNAL
vol.
17
,
S209
-
S210
.
Pryce G, Visintin C, Lutz B, Marsicano G, Giovannoni G, Selwood DL, Baker D
(
2011
)
.
Selective targeting of spasticity by CNS-excluded cannabinoids
.
MULTIPLE SCLEROSIS JOURNAL
vol.
17
,
S247
-
S247
.
Baker D, Pryce G, Visintin C, Pertwee RG, Tanner C, Ross R, Irving A, Sisay S et al.
(
2011
)
.
VSN16R a novel agent for the control of spasticity
.
MULTIPLE SCLEROSIS JOURNAL
vol.
17
,
S243
-
S243
.
Ayoub SS, Pryce G, Seed MP, Bolton C, Flower RJ, Baker D
(
2011
)
.
Paracetamol-induced hypothermia is independent of cannabinoids and transient receptor potential vanilloid-1 and is not mediated by AM404
.
Drug Metab Dispos
vol.
39
,
(
9
)
1689
-
1695
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Al-Izki S, Pryce G, Jackson SJ, Giovannoni G, Baker D
(
2011
)
.
Immunosuppression with FTY720 is insufficient to prevent secondary progressive neurodegeneration in experimental autoimmune encephalomyelitis
.
Mult Scler
vol.
17
,
(
8
)
939
-
948
.
Al-Izki S, Pryce G, Giovannoni G, Baker D
(
2009
)
.
Evaluating potential therapies for bladder dysfunction in a mouse model of multiple sclerosis with high-resolution ultrasonography
.
Mult Scler
vol.
15
,
(
7
)
795
-
801
.
Hampton DW, Anderson J, Pryce G, Irvine KA, Giovannoni G, Fawcett JW, Compston A, Franklin RJM et al.
(
2008
)
.
An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination, axonal and neuronal loss
.
J NEUROIMMUNOL
vol.
201
,
200
-
211
.
Jackson S, Al-Izik S, Pryce G, Giovannoni G, Baker D
(
2008
)
.
Fingolimod reduces axonal loss in relapsing secondary progressive experimental autoimmune encephalomyelitis
.
MULTIPLE SCLEROSIS
.
vol.
14
,
S80
-
S81
.
Parkes H, Shorter S, So PW, Baker D, Pryce G, Giovannoni G, Schmierer K
(
2008
)
.
High resolution 1H nuclear magnetic resonance spectroscopic-based metabolomic urine analysis of experimental autoimmune encephalitis, a model disease of multiple sclerosis
.
MULTIPLE SCLEROSIS
.
vol.
14
,
S86
-
S87
.
Al-Izki S, Pryce G, Jackson S, Giovannoni G, Baker D
(
2008
)
.
Neuroprotective effects of omega-3 fatty acids in a mouse model of multiple sclerosis
.
JOURNAL OF NEUROIMMUNOLOGY
.
vol.
197
,
173
-
173
.
Anderson JM, Hampton DW, Patani R, Pryce G, Crowther RA, Reynolds R, Franklin RJM, Giovannoni G et al.
(
2008
)
.
Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis
.
BRAIN
vol.
131
,
1736
-
1748
.
East E, Gverić D, Baker D, Pryce G, Lijnen HR, Cuzner ML
(
2008
)
.
Chronic relapsing experimental allergic encephalomyelitis (CREAE) in plasminogen activator inhibitor-1 knockout mice: the effect of fibrinolysis during neuroinflammation
.
Neuropathol Appl Neurobiol
vol.
34
,
(
2
)
216
-
230
.
Croxford JL, Pryce G, Jackson SJ, Ledent C, Giovannoni G, Pertwee RG, Yamamura T, Baker D
(
2008
)
.
Cannabinoid-mediated neuroprotection, not immuno suppression, may be more relevant to multiple sclerosis
.
J NEUROIMMUNOL
vol.
193
,
(
1-2
)
120
-
129
.
Pryce G, Jackson SJ, Baker D
(
2008
)
.
Cannabinoids for the control of multiple sclerosis
.
Cannabinoids and the Brain
,
Baker D, Pryce G
(
2008
)
.
The endocannabinoid system and multiple sclerosis
.
Curr Pharm Des
vol.
14
,
(
23
)
2326
-
2336
.
Baker D, Jackson SJ, Pryce G
(
2007
)
.
Cannabinoid control of neuroinflammation related to multiple sclerosis
.
Br J Pharmacol
vol.
152
,
(
5
)
649
-
654
.
Maresz K, Pryce G, Ponomarev ED, Marsicano G, Croxford JL, Shriver LP, Ledent C, Cheng XD et al.
(
2007
)
.
Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells
.
NAT MED
vol.
13
,
(
4
)
492
-
497
.
Pryce G, Baker D
(
2007
)
.
Control of spasticity in a multiple sclerosis model is mediated by CB1, not CB2, cannabinoid receptors
.
BRIT J PHARMACOL
vol.
150
,
(
4
)
519
-
525
.
Baker D, Croxford JL, Pryce G, Jackson SM, Ledent C, Marsicano G, Lutz B, Giovannoni G et al.
(
2006
)
.
Cannabinoid-mediated immunosuppression in experimental allergic encephalomyelitis
.
JOURNAL OF NEUROIMMUNOLOGY
.
vol.
178
,
90
-
91
.
Cabranes A, Pryce G, Baker D, Fernandez-Ruiz J
(
2006
)
.
Changes in CB1 receptors in motor-related brain structures of chronic relapsing experimental allergic encephalomyelitis mice
.
BRAIN RES
vol.
1107
,
199
-
205
.
Bilsland LG, Dick JRT, Pryce G, Petrosino S, Di Marzo V, Baker D, Greensmith L
(
2006
)
.
Increasing cannabinoid levels by pharmacological and genetic manipulation delay disease progression in SOD1 mice
.
FASEB J
vol.
20
,
(
7
)
1003
-
+
.
Baker D, Pryce G, Croxford JL, Yamamura T
(
2006
)
.
Cannabinoid-mediated immunosuppression in experimental allergic encephalomyelitits
.
CURRENT TOPICS IN NEUROIMMUNOLOGY
.
Editors:
Tabira, T, Yamamura, T, Kira, J
,
109
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116
.
Cristino L, De Petrocellis L, Pryce G, Baker D, Guglielmotti V, Di Marzo V
(
2006
)
.
Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain
.
NEUROSCIENCE
vol.
139
,
(
4
)
1405
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1415
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Baker D, Pryce G, Davies WL, Hiley CR
(
2006
)
.
In silico patent searching reveals a new cannabinoid receptor
.
Trends Pharmacol Sci
vol.
27
,
(
1
)
1
-
4
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Ligresti A, Cascio MG, Pryce G, Kulasegram S, Beletskaya I, De Petrocellis L, Saha B, Mahadevan A et al.
(
2006
)
.
New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis
.
BRIT J PHARMACOL
vol.
147
,
(
1
)
83
-
91
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de Lago E, Fernandez-Ruiz J, Ortega-Gutierrez S, Cabranes A, Pryce G, Baker D, Lopez-Rodriguez M, Ramos JA
(
2006
)
.
UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders
.
EUR NEUROPSYCHOPHARM
vol.
16
,
(
1
)
7
-
18
.
Heijmans N, Smith PA, Morris-Downes MM, Pryce G, Baker D, Donaldson AVJ, 't Hart B, Amor S
(
2005
)
.
Encephalitogenic and tolerogenic potential of altered peptide ligands of MOG and PLP in Biozzi ABH mice
.
J NEUROIMMUNOL
vol.
167
,
(
1-2
)
23
-
33
.
East E, Baker D, Pryce G, Lijnen HR, Cuzner ML, Gverić D
(
2005
)
.
A role for the plasminogen activator system in inflammation and neurodegeneration in the central nervous system during experimental allergic encephalomyelitis
.
Am J Pathol
vol.
167
,
(
2
)
545
-
554
.
Pryce G, O'Neill JK, Croxford JL, Amor S, Hankey DJ, East E, Giovannoni G, Baker D
(
2005
)
.
Autoimmune tolerance eliminates relapses but fails to halt progression in a model of multiple sclerosis
.
J NEUROIMMUNOL
vol.
165
,
(
1-2
)
41
-
52
.
Jackson SJ, Pryce G, Diemel LT, Cuzner ML, Baker D
(
2005
)
.
Cannabinoid-receptor 1 null mice are susceptible to neurofilament damage and caspase 3 activation
.
Neuroscience
vol.
134
,
(
1
)
261
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