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Publications:  Dr Ryan O'Shaughnessy

Tommasi C, Rogerson C, Depledge DP, Jones M, Naeem AS, Venturini C, Frampton D, Tutill HJ et al.(2020). Kallikrein-Mediated Cytokeratin 10 Degradation Is Required for Varicella Zoster Virus Propagation in Skin. Journal of Investigative Dermatology vol. 140, (4) 774-784.e11.
10.1016/j.jid.2019.08.448
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62237
O'Shaughnessy RFL(2019). Understanding actinic keratosis to reduce squamous cell carcinoma incidence. British Journal of Dermatology
10.1111/bjd.18529
https://qmro.qmul.ac.uk/xmlui/handle/123456789/61249
Shimomura Y, O'Shaughnessy R, Rajan N(2019). PLCD1 and Pilar Cysts. Journal of Investigative Dermatology vol. 139, (10) 2075-2077.
10.1016/j.jid.2019.05.027
Jones EM, Marsh S, O'Shaughnessy RF, Camera E, Picardo M, Aumailley M, O'Toole E, Caley M (2019). Junctional Epidermolysis Bullosa: Bottom Up Control Of The Skin Barrier?. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 139, S261-S261.
10.1016/j.jid.2019.07.708
Rogerson C, O'Shaughnessy RF (2019). Nuclear destruction during epidermal terminal differentiation requires actin cytoskeleton-mediated nuclear lamin dispersal and rapid nuclear volume reduction. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 139, S256-S256.
10.1016/j.jid.2019.07.247
Button R, Harwood C, O'Shaughnessy RF (2019). Understanding the roles of AKT1 loss and AKT2 activation during SCC progression. JOURNAL OF INVESTIGATIVE DERMATOLOGY. Conference: Melanoma and Other Skin Cancers vol. 139, S302-S302.
10.1016/j.jid.2019.07.560
https://qmro.qmul.ac.uk/xmlui/handle/123456789/64881
O'Shaughnessy R, Papaioannou E(2019). Sonic Hedgehog-signalling limits chronic dermatitis via Gli2-driven immune regulatory function. Journal of Clinical Investigation
10.1172/JCI125170
https://qmro.qmul.ac.uk/xmlui/handle/123456789/58853
Rogerson C, Odedra K, Landell-Mills A, O'Shaughnessy R (2019). Keratinocyte nuclear degradation requires Akt1-dependent lamin phosphorylation and the formation of lamin-containing cytoplasmic vesicles. BRITISH JOURNAL OF DERMATOLOGY. vol. 180, E184-E185.
Jones EM, Marsh ST, O'Shaughnessy RF, Aumailley M, Camera E, Picardo M, McGrath JA, O'Toole EA et al. (2019). Laminin 332: bottom-up control of the skin barrier?. BRITISH JOURNAL OF DERMATOLOGY. vol. 180, E185-E185.
Rogerson C, O'Shaughnessy R (2019). Epidermal nuclear degradation during terminal differentiation involves cytoplasmic dispersal of lamina proteins and rapid nuclear shrinkage. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 139, S59-S59.
O'Shaughnessy RFL(2019). Targeting tryptophan transport and breakdown in basal cell carcinoma. Br J Dermatol vol. 180, (1) 16-17.
10.1111/bjd.17316
https://qmro.qmul.ac.uk/xmlui/handle/123456789/54839
O'SHAUGHNESSY RFL(2018). Differential expression of secreted factors SOSTDC1 and ADAMTS8 cause profibrotic changes in linear morphoea fibroblasts. British Journal of Dermatology
10.1111/bjd.17352
https://qmro.qmul.ac.uk/xmlui/handle/123456789/49379
Tagoe HA, Hassan S, O'Shaughnessy R (2018). A Toll-like receptor-GATA3 signalling axis controls hyperkeratosis in severe ichthyoses. BRITISH JOURNAL OF DERMATOLOGY. vol. 178, E401-E401.
Rogerson C, O'Shaughnessy R (2018). Nuclear degradation in epidermal keratinocytes involves dispersal of nuclear lamina components to cytoplasmic vesicles. BRITISH JOURNAL OF DERMATOLOGY. vol. 178, E414-E415.
Rogerson C, O'Shaughnessy RF(2018). Protein kinases involved in epidermal barrier formation: The AKT family and other animals. Exp Dermatol
10.1111/exd.13696
https://qmro.qmul.ac.uk/xmlui/handle/123456789/41164
Jones E, Marsh S, O'Shaughnessy R, Aumailley M, O'Toole EA, Caley MP (2018). A role for the basement membrane in skin lipid trafficking. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 138, S116-S116.
Tommasi C, Breuer J, O'Shaughnessy R (2018). Kallikrein 6 (KLK6) mediated keratin 10 degradation is required for VZV propagation in skin. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 138, S154-S154.
Gutowska-Owsiak D, De La Serna JB, Fritzsche M, Naeem A, Podobas EI, Leeming M, Colin-York H, O'Shaughnessy R et al.(2018). Orchestrated control of filaggrin-actin scaffolds underpins cornification. Cell Death and Disease vol. 9, (4)
10.1038/s41419-018-0407-2
https://qmro.qmul.ac.uk/xmlui/handle/123456789/36394
Rogerson C, Bergamaschi D, O'Shaughnessy RFL(2017). Uncovering mechanisms of nuclear degradation in keratinocytes: A paradigm for nuclear degradation in other tissues. Nucleus1-9.
10.1080/19491034.2017.1412027
https://qmro.qmul.ac.uk/xmlui/handle/123456789/31325
Zhu Y, Underwood J, Macmillan D, Shariff L, O'Shaughnessy R, Harper JI, Pickard C, Friedmann PS et al.(2017). Persistent kallikrein 5 activation induces atopic dermatitis-like skin architecture independent of PAR2 activity. Journal of Allergy and Clinical Immunology vol. 140, (5) 1310-1322.e5.
10.1016/j.jaci.2017.01.025
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59415
Janus JM, O¿Shaughnessy RFL, Harwood CA, Maffucci T(2017). Phosphoinositide 3-kinase-dependent signalling pathways in cutaneous squamous cell carcinomas. Cancers vol. 9, (7)
10.3390/cancers9070086
https://qmro.qmul.ac.uk/xmlui/handle/123456789/25106
Naeem AS, Tommasi C, Cole C, Brown SJ, Zhu Y, Way B, Willis Owen SAG, Moffatt M et al.(2017). A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis. Journal of Allergy and Clinical Immunology vol. 139, (4) 1228-1241.
10.1016/j.jaci.2016.09.052
https://qmro.qmul.ac.uk/xmlui/handle/123456789/25006
Duurland CL, Brown CC, O'Shaughnessy RFL, Wedderburn LR(2017). CD161<sup>+</sup> Tconv and CD161<sup>+</sup> treg share a transcriptional and functional phenotype despite limited overlap in TCRβ repertoire. Frontiers in Immunology vol. 8, (MAR)
10.3389/fimmu.2017.00103
https://qmro.qmul.ac.uk/xmlui/handle/123456789/25038
Akinduro O, Harwood CA, O'Shaughnessy R, Bergamaschi D (2016). Epidermal autophagy and nucleophagy. JOURNAL OF INVESTIGATIVE DERMATOLOGY. Conference: European Society of Investigative Dermatology vol. 136, S183-S183.
10.1016/j.jid.2016.06.149
https://qmro.qmul.ac.uk/xmlui/handle/123456789/51526
Akinduro O, Sully K, Patel A, Robinson DJ, Chikh A, McPhail G, Braun KM, Philpott MP et al.(2016). Constitutive Autophagy and Nucleophagy during Epidermal Differentiation. Journal of Investigative Dermatology vol. 136, (7) 1460-1470.
10.1016/j.jid.2016.03.016
https://qmro.qmul.ac.uk/xmlui/handle/123456789/27303
Thomas AC, Zeng Z, Rivière JB, O'Shaughnessy R, Al-Olabi L, St.-Onge J, Atherton DJ, Aubert H et al.(2016). Mosaic Activating Mutations in GNA11 and GNAQ Are Associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis. Journal of Investigative Dermatology vol. 136, (4) 770-778.
10.1016/j.jid.2015.11.027
https://qmro.qmul.ac.uk/xmlui/handle/123456789/25589
Naeem AS, Zhu Y, Di WL, Marmiroli S, O'Shaughnessy RFL(2015). AKT1-mediated Lamin A/C degradation is required for nuclear degradation and normal epidermal terminal differentiation. Cell Death and Differentiation vol. 22, (12) 2123-2132.
10.1038/cdd.2015.62
https://qmro.qmul.ac.uk/xmlui/handle/123456789/34204
O'Shaughnessy RFL, Brown SJ(2015). Insight from the air-skin interface. Journal of Investigative Dermatology vol. 135, (2) 331-333.
10.1038/jid.2014.457
Kinsler VA, Drury S, Khan A, Waelchli R, Rukaite G, Barnicoat A, Lench N, Harper JI et al.(2015). A novel microdeletion in LOR causing autosomal dominant loricrin keratoderma. British Journal of Dermatology vol. 172, (1) 262-264.
10.1111/bjd.13361
https://qmro.qmul.ac.uk/xmlui/handle/123456789/28866
Youssef G, Ono M, Brown SJ, Kinsler VA, Sebire NJ, Harper JI, O'Shaughnessy RFL(2014). Identifying a hyperkeratosis signature in autosomal recessive congenital Ichthyosis: Mdm2 inhibition prevents hyperkeratosis in a rat ARCI model. Journal of Investigative Dermatology vol. 134, (3) 858-861.
10.1038/jid.2013.374
https://qmro.qmul.ac.uk/xmlui/handle/123456789/31683
Gerner L, Youssef G, O'Shaughnessy RFL(2013). The protein phosphatase 2A regulatory subunit Ppp2r2a is required for Connexin-43 dephosphorlyation during epidermal barrier acquisition. Experimental Dermatology vol. 22, (11) 754-756.
10.1111/exd.12234
Youssef G, Gerner L, Naeem AS, Ralph O, Ono M, O'Neill CA, O'Shaughnessy RFL(2013). Rab3Gap1 mediates exocytosis of Claudin-1 and tight junction formation during epidermal barrier acquisition. Developmental Biology vol. 380, (2) 274-285.
10.1016/j.ydbio.2013.04.034
Sully K, Akinduro O, Philpott MP, Naeem AS, Harwood CA, Reeve VE, O'Shaughnessy RF, Byrne C(2013). The mTOR inhibitor rapamycin opposes carcinogenic changes to epidermal Akt1/PKBα isoform signaling. Oncogene vol. 32, (27) 3254-3262.
10.1038/onc.2012.338
Akinduro O, Sully K, Chikh A, O'shaughnessy RF, Bergamaschi D, Harwood CA, Philpott MP, Byrne C (2013). Constitutive autophagy as a terminal differentiation mechanism. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 133, S127-S127.
O'shaughnessy RFL, Chaudhury I, Harper JI(2013). Insterleukin-1 alpha blockade prevents hyperkeratosis in an in vitro model of Lamellar ichthyosis. Human Molecular Genetics vol. 22, (5)
10.1093/hmg/dds511
Furmanski AL, O'Shaughnessy RFL, Saldana JI, Blundell MP, Thrasher AJ, Sebire NJ, Davies EG, Crompton T(2013). T-cell reconstitution after thymus xenotransplantation induces hair depigmentation and loss. Journal of Investigative Dermatology vol. 133, (5) 1221-1230.
10.1038/jid.2012.492
https://qmro.qmul.ac.uk/xmlui/handle/123456789/25472
Akinduro O, Sully K, O'Shaughnessy R, Harwood CA, Bergamaschi D, Byrne C (2012). A Novel Mechanism of Keratinocyte Terminal Differentiation - Autophagy?. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 132, S78-S78.
Ekeowa-Anderson AL, Purdie KJ, Gibbon K, Byrne CR, Arbeit JM, Harwood CA, O'Shaughnessy RFL(2012). AKT1 loss correlates with episomal HPV16 in Vulval intraepithelial neoplasia. PLoS ONE vol. 7, (6)
10.1371/journal.pone.0038608
https://qmro.qmul.ac.uk/xmlui/handle/123456789/4840
Akinduro O, Sully K, O'Shaughnessy RFL, Harwood CA, Bergamaschi D, Byrne C (2012). Autophagy in epidermis. BRITISH JOURNAL OF DERMATOLOGY. vol. 166, e31-e31.
Jackson B, Brown SJ, Avilion AA, O'Shaughnessy RFL, Sully K, Akinduro O, Murphy M, Cleary ML et al.(2011). TALE homeodomain proteins regulate site-specific terminal differentiation, LCE genes and epidermal barrier. Development vol. 138, (11) 1681-1690.
Jackson B, Brown SJ, Avilion AA, O'Shaughnessy RFL, Sully K, Akinduro O, Murphy M, Cleary ML et al.(2011). TALE homeodomain proteins regulate site-specific terminal differentiation, LCE genes and epidermal barrier. J Cell Sci vol. 124, (Pt 10) 1681-1690.
10.1242/jcs.077552
Sully K, Akinduro O, O'Shaughnessy RF, Harwood CA, Byrne C (2011). Understanding the tumour-suppressing role of rapamycin in epidermis. BRITISH JOURNAL OF DERMATOLOGY. vol. 164, 909-909.
Sully K, Akinduro OA, Philpott MP, Harwood CA, O'Shaughnessy RF, Byrne C (2011). Rapamycin treatment increases mTORC2 activity and selectively activates the AKT1 isoform in epidermis by inhibition of the mTORC1-dependent feedback loop to IRS-1. MOLECULAR BIOLOGY OF THE CELL. vol. 22,
O'Shaughnessy RFL, Choudhary I, Harper JI(2010). Interleukin-1 alpha blockade prevents hyperkeratosis in an in vitro model of lamellar ichthyosis. Human Molecular Genetics vol. 19, (13) 2594-2605.
10.1093/hmg/ddq145
Byrne C, Avilion AA, O'Shaughnessy RF, Welti JC, Hardman MJ(2010). Whole-mount assays for gene induction and barrier formation in the developing epidermis. Methods Mol Biol vol. 585, 271-286.
10.1007/978-1-60761-380-0_19
https://qmro.qmul.ac.uk/xmlui/handle/123456789/1002
O'Shaughnessy RFL, Welti JC, Sully K, Byrne C(2009). Akt-dependent Pp2a activity is required for epidermal barrier formation during late embryonic development. Development vol. 136, (20) 3423-3431.
10.1242/dev.037010
https://qmro.qmul.ac.uk/xmlui/handle/123456789/248
O'Shaughnessy RFL, Welti JC, Byrne CR (2009). AKT-dependent protein phosphatase 2A activity is necessary for epidermal barrier function and the correct formation of the cornified layer. BRITISH JOURNAL OF DERMATOLOGY. vol. 160, 903-903.
O'Shaughnessy RFL, Welti JC, Byrne CR (2008). Akt-dependent, protein phosphatase 2A-mediated formation of tight junctions is an initial component of the epidermal permeability barrier. BRITISH JOURNAL OF DERMATOLOGY. vol. 158, 879-879.
O'Shaughnessy RFL, Akg¿l B, Storey A, Pfister H, Harwood CA, Byrne C(2007). Cutaneous human papillomaviruses down-regulate AKT1, whereas AKT2 up-regulation and activation associates with tumors. Cancer Res vol. 67, (17) 8207-8215.
10.1158/0008-5472.CAN-07-0755
O'Shaughnessy RFL, Welti JC, Cooke JC, Avilion AA, Monks B, Birnbaum MJ, Byrne C(2007). AKT-dependent HspB1 (Hsp27) activity in epidermal differentiation. J Biol Chem vol. 282, (23) 17297-17305.
10.1074/jbc.M610386200
O'Shaughnessy RFL, Akgul B, Storey A, Pfister H, Harwood CA, Byrne C (2007). Cutaneous human papillomavirus early genes downregulate serine phosphorylated Akt1 while upregulating Akt2 expression. BRITISH JOURNAL OF DERMATOLOGY. vol. 156, 1109-1110.
Welti JC, O'Shaughnessy RFL, Byrne C (2007). Epidermal AKT signalling regulates SREBP transcription, epidermal lipogenesis and skin barrier activity. BRITISH JOURNAL OF DERMATOLOGY. vol. 156, 1101-1102.
O'Shaughnessy R, Welti J, Pfister H, Harwood C, Byrne C (2006). Cutaneous HPV early genes target epidermal AKT activity, altering heat-shock protein regulation of cornification. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 126, 108-108.
O'Shaughnessy RFL, Yeo W, Gautier J, Jahoda CAB, Christiano AM(2004). The WNT signalling modulator, Wise, is expressed in an interaction-dependent manner during hair-follicle cycling. J Invest Dermatol vol. 123, (4) 613-621.
10.1111/j.0022-202X.2004.23410.x
O'Shaughnessy RFL, Christiano AM, Jahoda CAB(2004). The role of BMP signalling in the control of ID3 expression in the hair follicle. Experimental Dermatology vol. 13, (10) 621-629.
10.1111/j.0906-6705.2004.00206.x
O'Shaughnessy RFL, Christiano AM(2004). Inherited disorders of the skin in human and mouse: From development to differentiation. International Journal of Developmental Biology vol. 48, (2-3) 171-179.
10.1387/ijdb.15272382
Jahoda CAB, Kljuic A, O'Shaughnessy R, Crossley N, Whitehouse CJ, Robinson M, Reynolds AJ, Demarchez M et al.(2004). The lanceolate hair rat phenotype results from a missense mutation in a calcium coordinating site of the desmoglein 4 gene. Genomics vol. 83, (5) 747-756.
10.1016/j.ygeno.2003.11.015
Kljuic A, Bazzi H, Sundberg JP, Martinez-Mir A, O'Shaughnessy R, Mahoney MG, Levy M, Montagutelli X et al.(2003). Desmoglein 4 in hair follicle differentiation and epidermal adhesion: Evidence from inherited hypotrichosis and acquired pemphigus vulgaris. Cell vol. 113, (2) 249-260.
10.1016/S0092-8674(03)00273-3
O'Shaughnessy RFL, Christiano AM(2001). Stem cells in the epidermis. Skin Pharmacology and Applied Skin Physiology vol. 14, (6) 350-357.
10.1159/000056368
Aberger F, Costa-Pereira AP, Schlaak JF, Williams TM, O'Shaughnessy RFL, Hollaus G, Kerr IM, Frischauf AMM(2001). Analysis of gene expression using high-density and IFN-γ-specific low-density cDNA arrays. Genomics vol. 77, (1-2) 50-57.
10.1006/geno.2001.6623
O'Shaughnessy RFL, Seery JP, Celis JE, Frischauf AM, Watt FM(2000). PA-FABP, a novel marker of human epidermal transit amplifying cells revealed by 2D protein gel electrophoresis and cDNA array hybridisation. FEBS Letters vol. 486, (2) 149-154.
10.1016/S0014-5793(00)02252-3
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