Publications: Prof Edel O'Toole

Wittmer AN, Nguyen CM, O'Toole E, Schwartz J, Evans H, Hansen D ( 2024 ) . Non‐pachyonychia congenita conditions in the International Pachyonychia Congenita Research Registry . International Journal of Dermatology

Coulombe PA, Hansen D, Hickerson R, Hovnanian A, O'Toole EA, Kelsell DP, Evans H, Schwartz J et al. ( 2024 ) . Celebrating 20 Years of the International Pachyonychia Congenita Consortium . Journal of Investigative Dermatology

O’Connor C, Passby L, Fields C, McGrath J, O’Toole EA, Rajan N ( 2024 ) . Mainstreaming genetic testing in dermatology in the UK . British Journal of Dermatology vol. 191 , ( 5 ) 832 - 833 .

de Brito M, O’Toole EA ( 2024 ) . Exploring the role of cytokeratin 17 in skin tumorigenesis and human papillomavirus persistence . British Journal of Dermatology vol. 191 , ( 6 ) 862 - 863 .

Clowes V, Ma X, Maude H, Dennis C, Gao Q, Quinn G, O’Toole EA, Batta K et al. ( 2024 ) . Homozygous HOXC13 Variant Causes Pure Hair and Nail Ectodermal Dysplasia via Reduction in Protein Stability . Human Mutation vol. 2024 , ( 1 )

McCarthy RL, de Brito M, O’Toole EA ( 2024 ) . Pachyonychia congenita: pathogenesis of pain and approaches to treatment . Clinical and Experimental Dermatology vol. 49 , ( 12 ) 1510 - 1517 .

Hughes AJ, Barbosa E, Cernova J, Thomas BR, O’Shaughnessy RFL, O’Toole EA ( 2024 ) . Loss-of-function FLG mutations are associated with reduced history of acne vulgaris in a cohort of patients with atopic eczema of Bangladeshi ancestry in East London . Clinical and Experimental Dermatology vol. 49 , ( 12 ) 1547 - 1553 .

Oldham J, O’Toole E ( 2024 ) . A case of Olmsted syndrome with dramatic response to erlotinib . Clinical and Experimental Dermatology vol. 49 , ( 12 ) 1755 - 1757 .

McCarthy RL, Schwartz J, Oldham J, Bodemer C, Greco C, Hovnanian A, Hansen CD, O’Toole EA ( 2024 ) . A cross-sectional study of erythromelalgia in patients with pachyonychia congenita . British Journal of Dermatology vol. 191 , ( 2 ) 300 - 302 .

Del Caño LR, South AP, O'Toole EA, Kelsell DP, Blaydon DC ( 2024 ) . A Role for Aquaporin-5 Variants in Regulation of the Actin Cytoskeleton in Non-Epidermolytic Palmoplantar Keratoderma . Journal of Investigative Dermatology vol. 144 , ( 9 ) 2092 - 2096 .

Papanikolaou M, Nattkemper L, Benzian-Olsson N, Liu L, Guy A, Lu H, Kadiyirire T, Hou P-C et al. ( 2024 ) . Th2 response drives itch in dystrophic epidermolysis bullosa pruriginosa: A case-control study . Journal of the American Academy of Dermatology vol. 91 , ( 1 ) 130 - 133 .

O'Toole EA, Kelsell DP, Caterina MJ, de Brito M, Hansen D, Hickerson RP, Hovnanian A, Kaspar R et al. ( 2023 ) . Pachyonychia Congenita: A Research Agenda Leading to New Therapeutic Approaches . Journal of Investigative Dermatology vol. 144 , ( 4 ) 748 - 754 .

McCarthy RL, Gnanappiragasam D, Scorer M, Taylor M, O’Toole EA ( 2023 ) . Cathepsin-C mutation in an individual with phenotypic features of Haim–Munk syndrome: a case report . Clinical and Experimental Dermatology vol. 48 , ( 11 ) 1298 - 1300 .

Valette C, Jonca N, Fischer J, Pernin‐Grandjean J, Tournier CG, Diociaiuti A, Neri I, Dreyfus I et al. ( 2023 ) . A retrospective study on the liver toxicity of oral retinoids in Chanarin–Dorfman syndrome . Journal of the European Academy of Dermatology and Venereology vol. 37 , ( 10 ) e1237 - e1241 .

McGeoghan F, Camera E, Maiellaro M, Menon M, Huang M, Dewan P, Ziaj S, Caley MP et al. ( 2023 ) . RNA sequencing and lipidomics uncovers novel pathomechanisms in recessive X-linked ichthyosis . Frontiers in Molecular Biosciences vol. 10 ,

Giusto E, Arbiser J, O'Toole E ( 2023 ) . 898 The proteasome inhibitor PTTC restores the lipid barrier in a harlequin ichthyosis in vitro skin model . Journal of Investigative Dermatology vol. 143 , ( 5 )

Junejo MH, Khan S, Larik EA, Akinkugbe A, O'Toole EA, Sethi A ( 2023 ) . Flooding and Climate Change and its Effect on Skin Disease . Journal of Investigative Dermatology vol. 143 , ( 8 ) 1348 - 1350 .

Smith CJ, Williams JL, Hall C, Casas J, Caley MP, O'Toole EA, Prasad R, Metherell LA ( 2023 ) . Ichthyosis linked to sphingosine 1-phosphate lyase insufficiency is due to aberrant sphingolipid and calcium regulation . Journal of Lipid Research vol. 64 , ( 4 )

Thomas BR, Tan XL, Van Duijvenboden S, Hogan SC, Hughes AJ, Tawfik SS, Dhoat S, Atkar R et al. ( 2023 ) . Deep palmar phenotyping in atopic eczema: patterns associated with filaggrin variants, disease severity and barrier function in a South Asian population . British Journal of Dermatology vol. 188 , ( 6 ) 785 - 792 .

Tawfik SS, Thomas BR, Kelsell DP, Grigg J, O’Toole EA ( 2022 ) . Dermatology Quality of Life Index scores in Bangladeshi patients with atopic eczema and their families in East London . British Journal of Dermatology vol. 188 , ( 4 ) 524 - 532 .

Kazmi A, Frewen J, McDonald B, Davison J, O'Toole E ( 2022 ) . Tuberous xanthoma secondary to homozygous familial hypercholesterolaemia: a life‐threatening diagnosis . Clinical and Experimental Dermatology vol. 47 , ( 12 ) 2336 - 2338 .

Mohamad J, Sarig O, Beattie P, Malovitski K, Assaf S, O’Toole E, Schwartz J, Evans H et al. ( 2022 ) . A unique skin phenotype resulting from a large heterozygous deletion spanning six keratin genes . British Journal of Dermatology vol. 187 , ( 5 ) 773 - 777 .

Steele L, Innes S, Oldham J, Cunningham M, Dhoat S, McDonald B, O’Toole EA ( 2022 ) . Safety outcomes for topical corticosteroid use in eczema herpeticum: a single-centre retrospective cohort study . British Journal of Dermatology vol. 188 , ( 2 ) 295 - 297 .

Smith CJ, Parkinson EK, Yang J, Pratten J, O'Toole EA, Caley MP, Braun KM ( 2022 ) . Investigating wound healing characteristics of gingival and skin keratinocytes in organotypic cultures . Journal of Dentistry vol. 125 ,

Tan XL, Thomas BR, Tan YJ, O’Toole EA ( 2022 ) . Effects of systemic therapies on pruritus in adults with atopic dermatitis: a systematic review and meta‐analysis . Clinical and Experimental Dermatology vol. 47 , ( 4 ) 658 - 666 .

Tan XL, Thomas BR, Steele L, Schwartz J, Hansen CD, O'Toole EA ( 2022 ) . Genotype-phenotype correlations of neurovascular structures on the feet in patients with pachyonychia congenita: A cross-sectional study . Journal of the American Academy of Dermatology . vol. 87 , 1172 - 1174 .

Steele L, Schwartz J, Hansen CD, O’Toole EA ( 2021 ) . Prevalence and Characterization of Itch in Pachyonychia Congenita . JAMA Dermatology vol. 157 , ( 11 ) 1378 - 1380 .

Thomas BR, Tan XL, Javadzadeh S, Robinson EJ, McDonald BS, Krupiczojc MA, Rahman SR, Rahman S et al. ( 2021 ) . Modelling of temporal exposure to the ambient environment and eczema severity . JID Innovations100062 - 100062 .

Heywood WE, Bliss E, Bahelil F, Cyrus T, Crescente M, Jones T, Iqbal S, Paredes LG et al. ( 2021 ) . Proteomic signatures for perioperative oxygen delivery in skin after major elective surgery: mechanistic sub-study of a randomised controlled trial . British Journal of Anaesthesia vol. 127 , ( 4 ) 511 - 520 .

Lincoln V, Chao L, Woodley DT, Murrell D, Kim M, O'Toole EA, Ly A, Cogan J et al. ( 2021 ) . Over‐expression of stromal periostin correlates with poor prognosis of cutaneous squamous cell carcinomas . Experimental Dermatology vol. 30 , ( 5 ) 698 - 704 .

Reynolds G, Vegh P, Fletcher J, Poyner EFM, Stephenson E, Goh I, Botting RA, Huang N et al. ( 2021 ) . Developmental cell programs are co-opted in inflammatory skin disease . Science vol. 371 , ( 6527 )

Langton AK, Ayer J, Griffiths TW, Rashdan E, Naidoo K, Caley MP, Birch‐Machin MA, O'Toole EA et al. ( 2020 ) . Distinctive clinical and histological characteristics of atrophic and hypertrophic facial photoageing . Journal of the European Academy of Dermatology and Venereology vol. 35 , ( 3 ) 762 - 768 .

Steele L, Tawfik SS, O'Toole EA ( 2020 ) . The Proteolytic Network in Palmoplantar Keratoderma: SERPINA12 Joins the Family . Journal of Investigative Dermatology vol. 140 , ( 11 ) 2111 - 2113 .

Steele L, Hong A, Balogh P, O'Toole EA, Harwood CA, Maruthappu T ( 2020 ) . Disseminated tinea incognita in a patient with ichthyosis vulgaris and eczema . Clinical and Experimental Dermatology vol. 46 , ( 1 ) 210 - 212 .

Caley MP, Martins VL, Moore K, Lashari M, Nissinen L, Kähäri V-M, Alexander S, Jones E et al. ( 2020 ) . Loss of Laminin α3 induces cell invasion and macrophage infiltration in cutaneous squamous cell carcinoma . British Journal of Dermatology

Bodemer C, Steijlen P, Mazereeuw‐Hautier J, O'Toole EA ( 2020 ) . Treatment of hereditary palmoplantar keratoderma: a review by analysis of the literature* . British Journal of Dermatology vol. 184 , ( 3 ) 393 - 400 .

Enjalbert F, Dewan P, Caley MP, Jones EM, Morse MA, Kelsell DP, Enright AJ, O'Toole EA ( 2020 ) . 3D model of harlequin ichthyosis reveals inflammatory therapeutic targets . Journal of Clinical Investigation

Mateo-Casas M, Reyes S, O'Toole EA, De Trane S, Yildiz O, Allen-Philbey K, Mathews J, Baker D et al. ( 2020 ) . Severe skin reactions associated with cladribine in people with multiple sclerosis . Multiple Sclerosis and Related Disorders . vol. 43 ,

Steele L, O'Toole EA ( 2020 ) . Pachyonychia congenita, a paradigm for rare skin disorders . British Journal of Dermatology vol. 182 , ( 3 ) 521 - 522 .

THOMAS BR, O’TOOLE EA ( 2020 ) . Diagnosis and Management of Inherited Palmoplantar Keratodermas . Acta Dermato Venereologica vol. 100 , ( 7 )

Kazmi A, O'Toole E, Maruthappu T ( 2020 ) . Not just skin deep: a complicated DRESS . BRITISH JOURNAL OF DERMATOLOGY . vol. 182 , E129 - E130 .

Funk T, Hansen CD, Paller A, O'Toole EA ( 2019 ) . Update on pachyonychia congenita research . British Journal of Dermatology vol. 182 , ( 3 ) 788 - 789 .

Thomas BR, Javadzadeh S, Robinson E, Ahmed R, Begum R, Rahman S, Khanam H, Kelsell DP et al. ( 2019 ) . 163 Eczema: Relationships between the environment, severity and the risk of admission to hospital . Journal of Investigative Dermatology . vol. 139 ,

Jones EM, Marsh S, O’Shaughnessy RF, CAMERA E, Picardo M, Aumailley M, O’Toole E, Caley M ( 2019 ) . 274 Junctional Epidermolysis Bullosa: Bottom Up Control Of The Skin Barrier? . Journal of Investigative Dermatology . vol. 139 ,

Caley M, Marsh S, Martins VL, Corbett-Jones T, Chen M, Di W, Sheer D, McGrath JA et al. ( 2019 ) . 298 Defective DNA Repair and Chromosomal Instability in RDEB . Journal of Investigative Dermatology . vol. 139 ,

Simpson JK, Martinez‐Queipo M, Onoufriadis A, Tso S, Glass E, Liu L, Higashino T, Scott W et al. ( 2019 ) . Genotype–phenotype correlation in a large English cohort of patients with autosomal recessive ichthyosis . British Journal of Dermatology vol. 182 , ( 3 ) 729 - 737 .

Theocharopoulos I, O'Toole EA ( 2019 ) . Stopping pachyonychia congenita plantar pain with a statin? . British Journal of Dermatology vol. 181 , ( 3 ) 446 - 447 .

Zamiri M, Wilson NJ, O'Toole EA, Smith FJD ( 2019 ) . Novel mutations in desmoglein 1: focal palmoplantar keratoderma in milder phenotypes . British Journal of Dermatology vol. 181 , ( 3 ) 618 - 620 .

Maruthappu T, Posafalvi A, Castelletti S, Delaney PJ, Syrris P, O'Toole EA, Green KJ, Elliott PM et al. ( 2019 ) . Loss‐of‐function desmoplakin I and II mutations underlie dominant arrhythmogenic cardiomyopathy with a hair and skin phenotype . British Journal of Dermatology vol. 180 , ( 5 ) 1114 - 1122 .

Javadzadeh S, O'Toole EA ( 2019 ) . Pyogenic granulomas as a side-effect of retinoid therapy, with ADAM17 as a potential key player: a case series . BRITISH JOURNAL OF DERMATOLOGY . vol. 181 , 83 - 83 .

Smith P, Dhillon‐Smith R, O'Toole E, Cooper N, Coomarasamy A, Clark T ( 2018 ) . Outcomes in prevention and management of miscarriage trials: a systematic review . BJOG An International Journal of Obstetrics & Gynaecology vol. 126 , ( 2 ) 176 - 189 .

Mazereeuw‐Hautier J, Vahlquist A, Traupe H, Bygum A, Amaro C, Aldwin M, Audouze A, Bodemer C et al. ( 2018 ) . Management of congenital ichthyoses: European guidelines of care, part one . British Journal of Dermatology vol. 180 , ( 2 ) 272 - 281 .

Mazereeuw‐Hautier J, Hernández‐Martín A, O'Toole EA, Bygum A, Amaro C, Aldwin M, Audouze A, Bodemer C et al. ( 2018 ) . Management of congenital ichthyoses: European guidelines of care, part two . British Journal of Dermatology vol. 180 , ( 3 ) 484 - 495 .

David J, O'Toole E, O'Reilly K, Thuery G, Assmann N, Finlay D, Harkin A ( 2018 ) . Inhibitors of the NMDA-Nitric Oxide Signaling Pathway Protect Against Neuronal Atrophy and Synapse Loss Provoked by l-alpha Aminoadipic Acid-treated Astrocytes . Neuroscience vol. 392 , 38 - 56 .

Castelletti S, Maruthappu T, Posafalvi A, Syrris P, O'Toole EA, Green KJ, Tinker A, McKenna WJ et al. ( 2018 ) . P5709Hair and cutaneous phenotypes linked to Arrhythmogenic Cardiomyopathy caused by Desmoplakin haploinsufficiency: an additional disease marker . European Heart Journal vol. 39 , ( suppl_1 )

Krupiczojc MA, O'Toole EA ( 2018 ) . Plantar pain in pachyonychia congenita . British Journal of Dermatology vol. 179 , ( 1 ) 11 - 12 .

KELSELL DP, O'TOOLE E, PIGORS M, SCOTT CA, Tabarra N, VAN HEEL DA ( 2018 ) . Exome sequencing and rare variant analysis reveals multiple filaggrin mutations in Bangladeshi atopic eczema families and novel risk genes . Journal of Investigative Dermatology

Bladen JC, Wang J, Sangaralingam A, Moosajee M, Fitchett C, Chelala C, Beaconsfield M, O’Toole EA et al. ( 2018 ) . MicroRNA and transcriptome analysis in periocular Sebaceous Gland Carcinoma . Scientific Reports vol. 8 , ( 1 )

Vodo D, O'Toole EA, Malchin N, Lahav A, Adir N, Sarig O, Green KJ, Smith FJD et al. ( 2018 ) . Striate palmoplantar keratoderma resulting from a missense mutation in DSG1 . British Journal of Dermatology vol. 179 , ( 3 ) 755 - 757 .

Enjalbert F, Dewan P, Caley MP, Fell B, Morse M, Kelsell D, Enright A, O'Toole EA ( 2018 ) . 661 Understanding the role of ABCA12 in the pathogenesis of harlequin ichthyosis . Journal of Investigative Dermatology . vol. 138 ,

Jones E, Marsh S, O'Shaughnessy R, Aumailley M, O'Toole EA, Caley MP ( 2018 ) . 680 A role for the basement membrane in skin lipid trafficking . Journal of Investigative Dermatology . vol. 138 ,

Marsh S, Caley MP, Martins V, Chen M, McGrath J, Barnes M, O'Toole EA ( 2018 ) . 812 Type VII collagen and Nesprin 2, LINCing the basement membrane to altered cell cycle and increased DNA damage . Journal of Investigative Dermatology . vol. 138 ,

Bladen JC, Moosajee M, Tracey-White D, Beaconsfield M, O’Toole EA, Philpott MP ( 2018 ) . Analysis of hedgehog signaling in periocular sebaceous carcinoma . Graefe's Archive for Clinical and Experimental Ophthalmology vol. 256 , ( 4 ) 853 - 860 .

McDonald BS, Pigors M, Kelsell DP, O'Toole EA, Burkitt‐Wright E, Kerr B, Batta K ( 2018 ) . Noonan syndrome with multiple lentigines and associated craniosynostosis . Clinical and Experimental Dermatology vol. 43 , ( 3 ) 357 - 359 .

Castelletti S, Maruthappu T, Posafalvi A, Syrris P, O'Toole EA, Green KJ, Tinker A, McKenna WJ et al. ( 2018 ) . Hair and cutaneous phenotypes linked to Arrhythmogenic Cardiomyopathy caused by Desmoplakin haploinsufficiency: an additional disease marker . EUROPEAN HEART JOURNAL . vol. 39 , 1206 - 1206 .

Smith CJ, Caley M, Parkinson EK, O'Toole EA, Pratten J, Yang J ( 2018 ) . INVESTIGATING THE DIFFERENCES IN THE WOUND HEALING RESPONSES OF SKIN AND GINGIVAL KERATINOCYTES . WOUND REPAIR AND REGENERATION . vol. 26 , A30 - A31 .

Wray EV, Wilson NJ, O'Toole E, Smith F, Zamiri M ( 2018 ) . Novel mutations in desmoglein 1: focal palmoplantar keratoderma in milder phenotypes . BRITISH JOURNAL OF DERMATOLOGY . vol. 179 , 82 - 83 .

Simpson J, Martinez-Queipo M, Onoufriadis A, Tso S, Glass E, Liu L, Higashino T, Scott W et al. ( 2018 ) . Phenotypic spectrum of 146 cases of autosomal recessive congenital ichthyosis in England . BRITISH JOURNAL OF DERMATOLOGY . vol. 179 , 80 - 81 .

Alexander SC, Marsh S, Caley M, O'Toole EA ( 2018 ) . Understanding Angiogenesis in Squamous Cell Carcinoma with Loss of Type VII Collagen . JOURNAL OF PATHOLOGY . vol. 246 , S44 - S44 .

Maruthappu T, McGinty LA, Blaydon DC, Fell B, Määttä A, Duit R, Hawkins T, Braun KM et al. ( 2017 ) . Recessive Mutation in FAM83G Associated with Palmoplantar Keratoderma and Exuberant Scalp Hair . Journal of Investigative Dermatology vol. 138 , ( 4 ) 984 - 987 .

Ip SCI, Cottle DL, Jones LK, Weir JM, Kelsell DP, O'Toole EA, Meikle PJ, Smyth IM ( 2017 ) . A profile of lipid dysregulation in harlequin ichthyosis . Br J Dermatol vol. 177 , ( 5 ) e217 - e219 .

Enjalbert F, Dewan P, Caley M, Fell B, Morse M, Kelsell DP, Enright A, O'Toole EA ( 2017 ) . Understanding the role of ABCA12 in the Pathogenesis of Harlequin Ichthyosis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . Conference: ESDR 2017 vol. 137 , S208 - S208 .

Thomas LJ, Freeman A, O'Toole EA, McGrath JA, Perrett CM ( 2017 ) . Inherited palmoplantar keratodermas: the heart of the matter . Clinical and Experimental Dermatology vol. 43 , ( 2 ) 228 - 230 .

Badowski C, Sim AYL, Verma C, Szeverényi I, Natesavelalar C, Terron-Kwiatkowski A, Harper J, O’Toole EA et al. ( 2017 ) . Modeling the Structure of Keratin 1 and 10 Terminal Domains and their Misassembly in Keratoderma . Journal of Investigative Dermatology vol. 137 , ( 9 ) 1914 - 1923 .

Kanapathy M, Hachach‐Haram N, Bystrzonowski N, Connelly JT, O'Toole EA, Becker DL, Mosahebi A, Richards T ( 2016 ) . Epidermal grafting for wound healing: a review on the harvesting systems, the ultrastructure of the graft and the mechanism of wound healing . International Wound Journal vol. 14 , ( 1 ) 16 - 23 .

McGeoghan F, Menon M, Dewan P, Caley M, Donaldson M, O’Toole EA ( 2016 ) . 132 Identification of novel pathways linked to the pathogenesis of Recessive X-Linked Ichthyosis . Journal of Investigative Dermatology . vol. 136 ,

Enjalbert F, Dewan P, Caley M, Fell B, Donaldson M, Kelsell DP, O’Toole EA ( 2016 ) . 133 Understanding the role of ABCA12 in the pathogenesis of Harlequin Ichthyosis . Journal of Investigative Dermatology . vol. 136 ,

Maruthappu T, McGinty L, Blaydon D, Duit R, Maatta A, O’Toole E, Kelsell DP ( 2016 ) . 180 Mutations in FAM83G/PAWS1 cause autosomal recessive palmoplantar keratoderma with leukonychia and abundant curly hair . Journal of Investigative Dermatology . vol. 136 ,

Posafalvi A, Maruthappu T, Castelletti S, Syrris P, O’Toole E, McKenna WJ, Kelsell DP ( 2016 ) . 183 Clinical and genetic studies reveal cutaneous phenotypes linked to desmoplakin haploinsufficiency in arrhythmogenic cardiomyopathy . vol. 136 , is. 9 , Elsevier

Caley M, Martins V, Moore K, Lashari M, Kähäri V, Nissinen L, Donaldson M, Marshall J et al. ( 2016 ) . 472 Loss of Laminin α3 drives SCC invasion via ROCK signalling . Journal of Investigative Dermatology . vol. 136 ,

McGeoghan FT, O’Toole E, Caley M, Menon M, Dewan P, Donaldson M ( 2016 ) . 375 Modelling and understanding pathomechanisms of X-linked recessive ichthyosis in vitro . Journal of Investigative Dermatology . vol. 136 ,

Pigors M, Common JE, Wong C, Malik S, Scott CA, Foo J, Liu J, Margolis D et al. ( 2016 ) . 380 Exome sequencing and rare variant analysis reveals multiple filaggrin mutations in Bangladeshi atopic eczema families and novel risk genes . Journal of Investigative Dermatology . vol. 136 ,

Chao L, Gor V, Murrell DF, Kim M, O’Toole E, Ly A, Woodley D, Wysong A et al. ( 2016 ) . 421 Over-expression of periostin is associated with clinical outcomes and poor prognosis in cutaneous squamous cell carcinoma . Journal of Investigative Dermatology . vol. 136 ,

Krupiczojc MA, O'Toole EA ( 2016 ) . Management of cutaneous squamous cell carcinoma in patients with epidermolysis bullosa . British Journal of Dermatology vol. 174 , ( 1 ) 15 - 15 .

Badowski C, Sim AYL, Verma C, Szeverenyi I, Dang TT, Ng Y, Natesavelalar C, Benny P et al. ( 2016 ) . A new model for the structure of the head domains of keratins K1 and K10 and its implications for striate palmoplantar keratoderma . BRITISH JOURNAL OF DERMATOLOGY . vol. 174 , E45 - E45 .

Kenny F, Kao A, Barber A, O'Toole E, Connelly J ( 2016 ) . Epidermal growth factor signalling mediates keratinocyte mechanoregulation . BRITISH JOURNAL OF DERMATOLOGY . vol. 174 , E44 - E44 .

Pigors M, Common JEA, Wong C, Scott CA, Foo JN, Liu J, O'Toole E, Simpson MA et al. ( 2016 ) . Exome sequencing reveals multiple filaggrin mutations in Bangladeshi families with atopic eczema . BRITISH JOURNAL OF DERMATOLOGY . vol. 174 , E64 - E65 .

Kelsell DP, Rajpopat S, Thomas A, O'Toole EA ( 2016 ) . Harlequin Ichthyosis: genetic, functional and clinical investigations . BRITISH JOURNAL OF DERMATOLOGY . vol. 175 , 50 - 50 .

Ahmed A, McGinty L, Blaydon D, Kelsell DP, O'Toole EA, De Silva B ( 2016 ) . Mild arthrogryposis, renal dysfunction and cholestasis syndrome caused by a novel splice-site mutation in <i>VPS33B</i> . BRITISH JOURNAL OF DERMATOLOGY . vol. 175 , 81 - 82 .

McDonald B, Amieva M, Kelsell DP, O'Toole EA, Burkett-Wright E, Kerr B, Batta K ( 2016 ) . Noonan syndrome with multiple lentigines identified by next-generation sequencing . BRITISH JOURNAL OF DERMATOLOGY . vol. 175 , 163 - 163 .

Ziaj S, Pigors M, Scott C, Lewis F, Ali I, Roberts N, Kelsell DP, O'Toole EA ( 2016 ) . Novel mutations in <i>SLURP1</i> causing Mal de Meleda palmoplantar keratoderma with varying phenotypes . BRITISH JOURNAL OF DERMATOLOGY . vol. 175 , 81 - 81 .

O'Toole EA, Ruban EL, Balogun M, Martins VL, Caley MP, Falasca M ( 2016 ) . Phospholipase C beta4 is a therapeutic target in cutaneous squamous cell carcinoma . BRITISH JOURNAL OF DERMATOLOGY . vol. 175 , 56 - 57 .

Caley M, Martins V, Moore K, Lashari M, Donaldson M, Marshall JF, O'Toole EA ( 2016 ) . ROCK and Rac1 signalling in squamous cell carcinoma with loss of laminin 332 . BRITISH JOURNAL OF DERMATOLOGY . vol. 174 , E51 - E51 .

Muttardi K, Nitoiu D, Kelsell DP, O'Toole EA, Batta K ( 2015 ) . Acral peeling skin syndrome associated with a novel CSTA gene mutation . Clinical and Experimental Dermatology vol. 41 , ( 4 ) 394 - 398 .

Thomson J, O'Toole EA ( 2015 ) . The future of U.K. dermatology translational research through the Oracle of Delphi . British Journal of Dermatology vol. 173 , ( 5 ) 1122 - 1123 .

Hill DS, Robinson NDP, Caley MP, Chen M, O'Toole EA, Armstrong JL, Przyborski S, Lovat PE ( 2015 ) . A Novel Fully Humanized 3D Skin Equivalent to Model Early Melanoma Invasion . Molecular Cancer Therapeutics vol. 14 , ( 11 ) 2665 - 2673 .

Kopecki Z, Yang GN, Jackson JE, Melville EL, Calley MP, Murrell DF, Darby IA, O'Toole EA et al. ( 2015 ) . Cytoskeletal protein Flightless I inhibits apoptosis, enhances tumor cell invasion and promotes cutaneous squamous cell carcinoma progression . Oncotarget vol. 6 , ( 34 ) 36426 - 36440 .

Martins VL, Caley MP, Moore K, Szentpetery Z, Marsh ST, Murrell DF, Kim MH, Avari M et al. ( 2015 ) . Suppression of TGFβ and Angiogenesis by Type VII Collagen in Cutaneous SCC . J Natl Cancer Inst vol. 108 , ( 1 )

Wee JS, Smith FJD, Wilson NJ, O'Toole EA ( 2015 ) . Focal PPK secondary to a novel KRT6C mutation (Pachyonychia congenita‐K6c) . Journal of the European Academy of Dermatology and Venereology vol. 30 , ( 8 ) 1415 - 1416 .

Wilson NJ, Cole C, Milstone LM, Kiszewski AE, Hansen CD, O'Toole EA, Schwartz ME, McLean WHI et al. ( 2015 ) . Expanding the Phenotypic Spectrum of Olmsted Syndrome . Journal of Investigative Dermatology vol. 135 , ( 11 ) 2879 - 2883 .

Lin Z, Zhao J, Nitoiu D, Scott CA, Plagnol V, Smith FJD, Wilson NJ, Cole C et al. ( 2015 ) . Loss-of-Function Mutations in CAST Cause Peeling Skin, Leukonychia, Acral Punctate Keratoses, Cheilitis, and Knuckle Pads . American Journal of Human Genetics vol. 96 , ( 3 ) 440 - 447 .

Knöbel M, O’Toole EA, Smith FJD ( 2015 ) . Keratins and skin disease . Cell and Tissue Research vol. 360 , ( 3 ) 583 - 589 .

Chinthapalli S, Buckley D, Lin Z, Nitoiu D, Scott C, Smith F, Yang Y, Kelsell D et al. ( 2015 ) . A novel peeling skin syndrome . BRITISH JOURNAL OF DERMATOLOGY . vol. 173 , 78 - 78 .

Kenny F, Kao A, Barber A, O'Toole E, Connelly JT ( 2015 ) . Epidermal growth factor signalling mediates mechanoregulation of keratinocyte proliferation . BRITISH JOURNAL OF DERMATOLOGY . vol. 172 , E33 - E33 .

McGeoghan F, Dewan P, Caley M, Donaldson M, O'Toole E ( 2015 ) . Generation of an <i>in vitro</i> three-dimensional model of X-linked recessive ichthyosis . BRITISH JOURNAL OF DERMATOLOGY . vol. 172 , E40 - E40 .

Marsh S, Martins V, Caley M, Barnes M, Donaldson MJ, O'toole E ( 2015 ) . Loss of keratinocyte type VII collagen induces pro-carcinogenic transcriptomic pathways . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 135 , S44 - S44 .

McGeoghan FT, Derwin P, Caley M, Donaldson MJ, O'toole E ( 2015 ) . Modelling X-linked recessive ichthyosis <i>in vitro</i> . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 135 , S62 - S62 .

Martins V, Caley M, Moore K, Szentpetery Z, Marsh S, Murrell DF, Kaehaeri V, McGrath J et al. ( 2015 ) . Skin type VII collagen acts as a tumour suppressor by regulating TGFβ and angiogenesis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 135 , S28 - S28 .

Caley M, Martins V, Marsh S, Moore K, Lashari M, Donaldson MJ, Marshall J, O'toole E ( 2015 ) . Squamous Cell Carcinoma progression and Laminin 332 . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 135 , S23 - S23 .

O'Toole EA, Kaspar RL, Sprecher E, Schwartz ME, Rittié L ( 2014 ) . Pachyonychia congenita cornered: report on the 11th Annual International Pachyonychia Congenita Consortium Meeting . Br J Dermatol vol. 171 , ( 5 ) 974 - 977 .

Brooke MA, O'Toole EA, Kelsell DP ( 2014 ) . Exoming into rare skin disease: EGFR deficiency . J Invest Dermatol vol. 134 , ( 10 ) 2486 - 2488 .

Cichoń MA, Szentpetery Z, Caley MP, Papadakis ES, Mackenzie IC, Brennan CH, O'Toole EA ( 2014 ) . The receptor tyrosine kinase Axl regulates cell-cell adhesion and stemness in cutaneous squamous cell carcinoma . Oncogene vol. 33 , ( 32 ) 4185 - 4192 .

Brooke MA, Etheridge SL, Kaplan N, Simpson C, O'Toole EA, Ishida-Yamamoto A, Marches O, Getsios S et al. ( 2014 ) . iRHOM2-dependent regulation of ADAM17 in cutaneous disease and epidermal barrier function . Hum Mol Genet vol. 23 , ( 15 ) 4064 - 4076 .

Ooi J, Chinthapalli S, O'Toole E, Alazawi W ( 2014 ) . PWE-142 Is Liver Disease Overlooked In Patients With Psoriasis? . Gut vol. 63 Suppl 1 ,

O'Toole EA ( 2014 ) . Type VII collagen and squamous cell carcinoma . Br J Dermatol vol. 170 , ( 6 )

Brown L, Waseem A, Cruz IN, Szary J, Gunic E, Mannan T, Unadkat M, Yang M et al. ( 2014 ) . Desmoglein 3 promotes cancer cell migration and invasion by regulating activator protein 1 and protein kinase C-dependent-Ezrin activation . Oncogene vol. 33 , ( 18 ) 2363 - 2374 .

Kulkarni M, O'Loughlin A, Vazquez R, Mashayekhi K, Rooney P, Greiser U, O'Toole E, O'Brien T et al. ( 2014 ) . Use of a fibrin-based system for enhancing angiogenesis and modulating inflammation in the treatment of hyperglycemic wounds . Biomaterials vol. 35 , ( 6 ) 2001 - 2010 .

Bladen J, Thaung C, Beaconsfield M, O'Toole E, Philpott M ( 2014 ) . Analysis of the Hedgehog signalling pathway in periocular sebaceous gland carcinoma . INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE . vol. 55 ,

Kopecki Z, Yang G, Jackson J, Melville E, Martin V, Caley M, Proby C, Pouniotis D et al. ( 2014 ) . Cytoskeletal protein Flii is elevated in human cSCCs and overexpression of Flii in mice leads to higher incidence and severity of tumour formation . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 134 , S28 - S28 .

Caley M, Martins V, Moore K, Marshall J, O'toole E ( 2014 ) . Diverse roles for laminin 332 subunits in squamous cell carcinoma . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 134 , S19 - S19 .

Caley M, Martins V, Moore K, Marshall J, O'Toole E ( 2014 ) . Diverse roles for laminin-332 subunits in squamous cell carcinoma . BRITISH JOURNAL OF DERMATOLOGY . vol. 170 , E26 - E26 .

Marsh S, Martins V, Caley M, Barnes M, Donaldson M, O'Toole E ( 2014 ) . Global transcriptomic changes in primary keratinocytes with loss of basement membrane genes . BRITISH JOURNAL OF DERMATOLOGY . vol. 170 , E37 - E38 .

Sommerlad M, Scott C, Harwood C, Kelsell D, O'Toole E ( 2014 ) . Ichthyosis with striate keratoderma caused by a compound heterozygous mutation in ichthyin/<i>NIPAL4</i> . BRITISH JOURNAL OF DERMATOLOGY . vol. 171 , 118 - 119 .

Lin Z, Nitoiu D, Scott C, Zhao J, Plagnol V, O'toole E, Kelsell D, Yang Y ( 2014 ) . Peeling skin, leukonychia, acral punctate keratoses, cheilitis and knuckle pads with milia caused by loss-of-function mutations in calpastatin . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 134 , S53 - S53 .

Muttardi K, Nitoiu D, Kelsell DP, O'Toole EA, Batta K ( 2014 ) . Peeling the surface of cystatin A defects . BRITISH JOURNAL OF DERMATOLOGY . vol. 171 , 117 - 118 .

Ruban EL, Balogun MA, Martins V, Caley M, Raimondi C, O'toole E, Falasca M ( 2014 ) . Phospholipase C beta4 regulates invasion and proliferation in cutaneous SCC <i>in vivo</i> . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 134 , S22 - S22 .

Marsh S, Martins V, Caley M, Barnes M, Donaldson M, O'toole E ( 2014 ) . RNA-Seqing the skin basement membrane . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 134 , S25 - S25 .

Jones M, Dry IR, Frampton D, Singh M, Kanda RK, Yee MB, Kellam P, Hollinshead M et al. ( 2014 ) . RNA-seq analysis of host and viral gene expression highlights interaction between varicella zoster virus and keratinocyte differentiation . PLoS Pathog vol. 10 , ( 1 )

Ahmed H, O'Toole EA ( 2014 ) . Recent advances in the genetics and management of harlequin ichthyosis . Pediatr Dermatol vol. 31 , ( 5 ) 539 - 546 .

Kopecki Z, Yang G, Jackson J, Melville E, Martin V, Matthew C, Proby C, Pouniotis D et al. ( 2014 ) . TREATMENT OF SCC WITH FLIGHTLESS NEUTRALIZING ANTIBODY BLOCKS CELL INVASION AND REDUCES TUMOR GROWTH IN MICE . WOUND REPAIR AND REGENERATION vol. 22 , ( 2 ) A49 - A49 .

Wilson NJ, O'Toole EA, Milstone LM, Hansen CD, Shepherd AA, Al-Asadi E, Schwartz ME, McLean WHI et al. ( 2014 ) . The molecular genetic analysis of the expanding pachyonychia congenita case collection . BRITISH JOURNAL OF DERMATOLOGY vol. 171 , ( 2 ) 343 - 355 .

Blaydon DC, Lind LK, Plagnol V, Linton KJ, Smith FJD, Wilson NJ, McLean WHI, Munro CS et al. ( 2013 ) . Mutations in AQP5, encoding a water-channel protein, cause autosomal-dominant diffuse nonepidermolytic palmoplantar keratoderma . Am J Hum Genet vol. 93 , ( 2 ) 330 - 335 .

O'TOOLE EA, GOEL M, WOODLEY DT ( 2013 ) . Hydrogen Peroxide Inhibits Human Keratinocyte Migration . Dermatologic Surgery vol. 22 , ( 6 ) 525 - 529 .

Martins VL, Caley M, O'Toole EA ( 2013 ) . Matrix metalloproteinases and epidermal wound repair . Cell Tissue Res vol. 351 , ( 2 ) 255 - 268 .

Scott CA, Plagnol V, Nitoiu D, Bland PJ, Blaydon DC, Chronnell CM, Poon DS, Bourn D et al. ( 2013 ) . Targeted sequence capture and high-throughput sequencing in the molecular diagnosis of ichthyosis and other skin diseases . J Invest Dermatol vol. 133 , ( 2 ) 573 - 576 .

Blaydon DC, Lind L, Plagnol V, Linton KJ, South AP, Leigh IM, O'Toole EA, Lundstrom A et al. ( 2013 ) . Aquaporin 5 (AQP5), a water channel protein, is mutated in autosomal dominant diffuse non-epidermolytic palmoplantar keratoderma . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 133 , S139 - S139 .

Caley MP, Martins V, Moore K, Marshall JF, O'Toole EA ( 2013 ) . Diverse roles for laminin 332 subunits in squamous cell carcinoma . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 133 , S64 - S64 .

Martins VL, Caley MP, Moore K, Szentpetery Z, Murrell DF, Kim MH, McGrath JA, Cerio R et al. ( 2013 ) . Loss of type VII collagen in cutaneous SCC increases angiogenesis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 133 , S158 - S158 .

Ruban EL, Martins VL, Caley M, Raimondi C, Falasca M, O'Toole EA ( 2013 ) . Phospholipase C-beta 4 regulates proliferation and invasion in cutaneous SCC . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 133 , S73 - S73 .

Marsh ST, Martins VL, Donaldson M, Braun K, O'Toole EA ( 2013 ) . Regulation of normal epidermal homeostasis by the basement membrane . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 133 , S157 - S157 .

Scott CA, Plagnol V, Nitoiu D, Bland PJ, Blaydon DC, Chronnell CM, Poon DS, Bourn D et al. ( 2013 ) . Targeted sequence capture and high-throughput sequencing in the molecular diagnosis of ichthyosis and other skin diseases . Journal of Investigative Dermatology vol. 133 , ( 2 ) 573 - 576 .

Szentpetery Z, Lovat PE, Bergamaschi D, O'Toole EA ( 2013 ) . The receptor tyrosine kinase, Axl, as a therapeutic target in malignant melanoma . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 133 , S240 - S240 .

Marsh ST, Caley MP, Kwan A, O'Toole EA, Donaldson M ( 2013 ) . Transcriptome profiling identifies novel functions of acitretin in human epidermis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 133 , S186 - S186 .

Scott CA, Tattersall D, O'Toole EA, Kelsell DP ( 2012 ) . Connexins in epidermal homeostasis and skin disease . Biochimica et Biophysica Acta - Biomembranes vol. 1818 , ( 8 ) 1952 - 1961 .

Tsang SM, Brown L, Lin K, Liu L, Piper K, O'Toole EA, Grose R, Hart IR et al. ( 2012 ) . Non-junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris . J Pathol vol. 227 , ( 1 ) 81 - 93 .

Wan H, Brown L, Gunic E, Mannan T, Tsang S, Valderrama F, O'Toole E ( 2012 ) . Desmoglein 3 Regulates Cancer Cell Migration Through PKC Dependent-ezrin Activation . EUROPEAN JOURNAL OF CANCER . vol. 48 , S45 - S46 .

Brown LE, Gunic E, Unadkat M, Mannan T, Tsang S, Ahmed W, Valderrama F, O'Toole EA et al. ( 2012 ) . Desmoglein 3 regulates cancer cell migration through Protein Kinase C dependent-ezrin activation . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 132 , S37 - S37 .

Kulkarni M, O'Loughlin A, Vazquez-Martinez R, Mashayekhi K, Greiser U, O'Toole E, O'Brien T, Malagon M et al. ( 2012 ) . Fibrin mediated proangiogenic and secretory control gene therapy for compromised wound healing . JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE vol. 6 , 291 - 291 .

Singh M, Caley M, Jones M, Breuer J, O'Toole E ( 2012 ) . Keratin 15 and VZV replication in skin . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 132 , S112 - S112 .

Martins V, Caley M, Moore K, Murrell DF, McGrath JA, Chen M, Marshall JF, O'Toole EA ( 2012 ) . Loss of keratinocyte type VII collagen in SCC increases TGF-beta signalling and angiogenesis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 132 , S45 - S45 .

Martins V, Caley M, Moore K, Chen M, Marshall J, O'Toole E ( 2012 ) . Loss of type VII collagen in squamous cell carcinoma increases angiogenesis <i>in vitro</i> and <i>in vivo</i> . BRITISH JOURNAL OF DERMATOLOGY . vol. 166 , e25 - e26 .

Tull T, Chu A, O'Toole E, Teixeira F, Schmid K, Punjabi S ( 2012 ) . Macrocephaly: Capillary malformation with the neuroradiologic features of Sturge-Weber syndrome: A syndrome overlap? . JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY . vol. 66 , AB95 - AB95 .

Scott C, Bland P, Plagnol V, Nitoiu D, Poon D, O'Toole E, Kelsell D ( 2012 ) . Next-generation sequencing in genetic diagnosis of skin disease . BRITISH JOURNAL OF DERMATOLOGY . vol. 166 , e34 - e34 .

Ruban EL, Martins VL, Falasca M, O'Toole EA ( 2012 ) . Phospholipase C signalling in cutaneous squamous cell carcinoma . BRITISH JOURNAL OF DERMATOLOGY . vol. 166 , e23 - e24 .

Szentpetery Z, Cichon M, Caley M, O'Toole E ( 2012 ) . The receptor tyrosine kinase Axl regulates intercellular adhesion, epithelial-mesenchymal transition and stemness in cutaneous squamous cell carcinoma . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 132 , S45 - S45 .

Marsh S, Martins V, Braun K, Donaldson M, O'Toole E ( 2012 ) . The role of the basement membrane in normal epidermal homeostasis . BRITISH JOURNAL OF DERMATOLOGY . vol. 166 , e32 - e32 .

Marsh ST, Martins V, Braun K, Donaldson M, O'Toole EA ( 2012 ) . The role of the basement membrane in stem cell maintenance and epidermal homeostasis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 132 , S34 - S34 .

Kulkarni M, O'loughlin A, Vazquez R, Mashayekhi K, Greiser U, O'toole EA, O'brien T, Malagon MM et al. ( 2011 ) . Spatiotemporally controlled proangiogenic and secretory control therapy for compromised wound healing . 24th European Conference on Biomaterials - Annual Conference of the European Society for Biomaterials .

Blaydon DC, Biancheri P, Di W-L, Plagnol V, Cabral RM, Brooke MA, van Heel DA, Ruschendorf F et al. ( 2011 ) . Inflammatory skin and bowel disease linked to ADAM17 deletion . N Engl J Med vol. 365 , ( 16 ) 1502 - 1508 .

Ruban E, Martins V, Falasca M, O'Toole E ( 2011 ) . Phospholipase C signalling in cutaneous squamous cell carcinoma . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 131 , S32 - S32 .

Marsh S, Martins V, O'Toole E ( 2011 ) . The role of the basement membrane in normal epidermal homeostasis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 131 , S33 - S33 .

Dewan P, Robinson J, O'Toole E, Paige DG, Goldsmith P ( 2011 ) . Need for transition in dermatology: a study from a London teaching hospital . BRITISH JOURNAL OF DERMATOLOGY . vol. 165 , 20 - 20 .

Dewan P, Terron-Kwiatkowski A, Rajpopat S, Dopping-Hepenstal PJ, McGrath JA, Baty D, O'Toole EA ( 2011 ) . Recessive epidermolytic palmoplantar keratoderma caused by a keratin 1 mutation . BRITISH JOURNAL OF DERMATOLOGY . vol. 165 , 120 - 120 .

Rajpopat S, Moss C, Mellerio J, Vahlquist A, Gånemo A, Hellstrom-Pigg M, Ilchyshyn A, Burrows N et al. ( 2011 ) . Harlequin ichthyosis: a review of clinical and molecular findings in 45 cases . Arch Dermatol vol. 147 , ( 6 ) 681 - 686 .

O'Toole EA, Kelsell DP ( 2011 ) . Collodion Baby . Harper's Textbook of Pediatric Dermatology , Wiley

O'Toole EA, Kelsell DP ( 2011 ) . Harlequin Ichthyosis . Harper's Textbook of Pediatric Dermatology , Wiley

Martinez-Levasseur LM, Gendron D, Knell RJ, O'Toole EA, Singh M, Acevedo-Whitehouse K ( 2011 ) . Acute sun damage and photoprotective responses in whales . Proc Biol Sci vol. 278 , ( 1711 ) 1581 - 1586 .

Cichon MA, Mackenzie IC, O'Toole EA ( 2011 ) . Axl plays a role in cell adhesion and 'stemness' in cutaneous SCC . BRITISH JOURNAL OF DERMATOLOGY . vol. 164 , 908 - 909 .

Martins VL, Moore K, Chen M, Marshall J, O'Toole EA ( 2011 ) . Loss of type VII collagen in SCC leads to increased invasion and TGF-beta signalling in vivo . BRITISH JOURNAL OF DERMATOLOGY . vol. 164 , 910 - 910 .

Ruban EL, Martins VL, Falasca M, O'Toole EA ( 2011 ) . Phospholipase C signalling in cutaneous squamous cell carcinoma . BRITISH JOURNAL OF DERMATOLOGY . vol. 164 , 935 - 935 .

Dewan P, Terron-Kwiatkowski A, Rajpopat S, Baty D, O'Toole EA ( 2011 ) . Recessive epidermolytic palmoplantar keratoderma caused by a keratin 1 mutation . BRITISH JOURNAL OF DERMATOLOGY . vol. 164 , 932 - 932 .

Wong S, Rizvi H, Cerio R, O'Toole EA ( 2011 ) . An unusual case of vulval papulonecrotic tuberculid . Clin Exp Dermatol vol. 36 , ( 3 ) 277 - 280 .

Martins V, Moore K, Chen M, Marshall J, O'Toole EA ( 2011 ) . Loss of type VII collagen in squamous cell carcinoma leads to increased invasion and TGF-beta signalling in vivo . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 131 , S33 - S33 .

Talsania N, Jolliffe V, O'Toole EA, Cerio R ( 2011 ) . Platelike osteoma cutis . J Am Acad Dermatol vol. 64 , ( 3 ) 613 - 615 .

Thomas KS, Koller K, Dean T, O'Leary CJ, Sach TH, Frost A, Pallett I, Crook AM et al. ( 2011 ) . A multicentre randomised controlled trial and economic evaluation of ion-exchange water softeners for the treatment of eczema in children: the Softened Water Eczema Trial (SWET) . Health Technology Assessment vol. 15 , ( 8 ) 1 - 156 .

Martinez-Levasseur LM, Gendron D, Knell RJ, O'Toole EA, Singh M, Acevedo-Whitehouse K ( 2011 ) . Acute sun damage and photoprotective responses in whales . Proceedings of the Royal Society B vol. 278 , ( 1711 ) 1581 - 1586 .

Scott CA, Tattersall D, O'Toole EA, Kelsell DP ( 2011 ) . Connexins in epidermal homeostasis and skin disease . Biochimica et Biophysica Acta - Biomembranes

Scott CA, O'Toole EA, Mohungoo MJ, Messenger A, Kelsell DP ( 2011 ) . Novel and recurrent connexin 30.3 and connexin 31 mutations associated with erythrokeratoderma variabilis . Clin Exp Dermatol vol. 36 , ( 1 ) 88 - 90 .

Martins V, Chen M, Purdie K, O'Toole E ( 2010 ) . Loss of type VII collagen in cutaneous SCC increases cell invasion through TGF-beta signalling . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 130 , S19 - S19 .

Ruban E, Martins V, Falasca M, O'Toole E ( 2010 ) . Phospholipase C signalling in cutaneous squamous cell carcinoma . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 130 , S31 - S31 .

Cichon M, Mackenzie I, O'Toole E ( 2010 ) . The role of the receptor tyrosine kinase Axl in intercellular adhesion and signalling in cutaneous squamous cell carcinoma . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 130 , S15 - S15 .

O'Toole EA ( 2010 ) . Molecular Biology . Rook's Textbook of Dermatology: Eighth Edition , vol. 1 ,

O'Toole EA, Mellerio JE ( 2010 ) . Wound Healing . Rook's Textbook of Dermatology: Eighth Edition , vol. 1 ,

Martins VL, Chen M, Purdie KJ, O'Toole EA ( 2010 ) . Inhibition of the transforming growth factor-beta pathway decreases cell movement in squamous cell carcinoma cells with loss of type VII collagen . BRITISH JOURNAL OF DERMATOLOGY . vol. 162 , 947 - 947 .

Rajpopat S, Poon DS, O'Toole EA, Kelsell DP ( 2010 ) . Loss of ABCA12 leads to dysregulated expression of the nuclear hormone receptor pathway molecules RXR-alpha, PPAR-delta and the lipid transporter ABCA1 . BRITISH JOURNAL OF DERMATOLOGY . vol. 162 , 939 - 939 .

Cichon MA, Mackenzie IC, O'Toole EA ( 2010 ) . The role of the receptor tyrosine kinase Axl in cell-cell adhesion and signaling in cancer . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 130 , S34 - S34 .

Cichon MA, Mackenzie IC, O'Toole EA ( 2010 ) . The role of the receptor tyrosine kinase Axl in intercellular adhesion and signalling in cancer . BRITISH JOURNAL OF DERMATOLOGY . vol. 162 , 922 - 922 .

Singh M, Breuer J, Heseltine R, Cerio R, Millar J, Philpott MP, O'Toole EA ( 2010 ) . Varicella-zoster replication and its association with keratin 15 expression and Wnt signalling . BRITISH JOURNAL OF DERMATOLOGY . vol. 162 , 914 - 915 .

Majmudar V, Herath D, O'Toole EA, Harrison A ( 2010 ) . Bullous pemphigoid of childhood: a rare disease with diagnostic and management challenges . CLIN EXP DERMATOL vol. 35 , ( 2 ) 213 - 214 .

Wilson NJ, Messenger AG, Leachman SA, O'Toole EA, Lane EB, McLean WHI, Smith FJD ( 2010 ) . Keratin K6c Mutations Cause Focal Palmoplantar Keratoderma . J INVEST DERMATOL vol. 130 , ( 2 ) 425 - 429 .

Papadakis ES, Cichon M, Vyas JJ, Patel N, Ghali L, Cerio R, Storey A, O'Toole EA ( 2010 ) . Axl Promotes Cutaneous Squamous Cell Carcinoma Survival Through Negative Regulation of Pro-Apoptotic Bcl-2 Family Members . Journal of Investigative Dermatology vol. 131 , 509 - 517 .

South AP, O'Toole EA ( 2010 ) . Understanding the Pathogenesis of Recessive Dystrophic Epidermolysis Bullosa Squamous Cell Carcinoma . DERMATOL CLIN vol. 28 , ( 1 ) 171 - + .

Talsania N, O'Toole EA ( 2009 ) . Severe hypersensitivity reaction to minocycline in association with lymphomatoid papulosis . Clin Exp Dermatol vol. 34 , ( 7 ) e397 - e398 .

Papadakis ES, Storey A, O'Toole EA ( 2009 ) . A role for the receptor tyrosine kinase Axl in regulating NF-kappa B activity in cutaneous squamous cell carcinomas . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 129 , S72 - S72 .

Rajpopat S, O'Toole EA, Kelsell DP ( 2009 ) . Harlequin ichthyosis: prenatal diagnosis and a review of the clinical outcome of survivors . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 129 , S52 - S52 .

Martins VL, Chen M, Purdie K, McGrath JA, O Toole EA ( 2009 ) . Increased invasive behaviour in cutaneous squamous cell carcinoma with loss of type VII collagen . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 129 , S82 - S82 .

Cichon MA, Papadakis ES, Mackenzie IC, O'Toole EA ( 2009 ) . The role of the receptor tyrosine kinase, Axl, in intercellular adhesion and signalling in cutaneous squamous cell carcinoma . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 129 , S79 - S79 .

Vlachou C, O'Toole EA, Kelsell DP, Batta K ( 2009 ) . A new autosomal dominant pure hair-nail ectodermal dysplasia showing variable expression within a family . BRITISH JOURNAL OF DERMATOLOGY . vol. 161 , 126 - 126 .

Singh M, Heseltine R, Millar J, Cerio R, Breuer J, O'Toole EA ( 2009 ) . Localization of varicella-zoster virus reactivation in neuronal and adnexal structures in skin . BRITISH JOURNAL OF DERMATOLOGY . vol. 161 , 88 - 88 .

Martins VL, Vyas JJ, Chen M, Purdie K, Mein CA, South AP, Storey A, McGrath JA et al. ( 2009 ) . Increased invasive behaviour in cutaneous squamous cell carcinoma with loss of basement-membrane type VII collagen . J Cell Sci vol. 122 , ( Pt 11 ) 1788 - 1799 .

Sinclair C, O'Toole EA, Paige D, El Bashir H, Robinson J, Dobson R, Lench N, Stevens HP et al. ( 2009 ) . Filaggrin mutations are associated with ichthyosis vulgaris in the Bangladeshi population . Br J Dermatol vol. 160 , ( 5 ) 1113 - 1115 .

Papadakis ES, Vyas JJ, Patel N, Ghali L, Storey A, O'Toole EA ( 2009 ) . An antiapoptotic role for the receptor tyrosine kinase Axl in cutaneous squamous cell carcinoma . BRITISH JOURNAL OF DERMATOLOGY . vol. 160 , 924 - 924 .

Martins VL, Vyas JJ, Chen M, Purdie KJ, South AP, Storey A, McGrath JA, O'Toole EA ( 2009 ) . Mechanisms of increased invasion of cutaneous squamous cell carcinoma cells with loss of type VII collagen . BRITISH JOURNAL OF DERMATOLOGY . vol. 160 , 906 - 906 .

Rajpopat S, O'Toole EA, Kelsell DP ( 2009 ) . Prenatal diagnosis of harlequin ichthyosis, the search for novel mutations and a review of clinical outcome . BRITISH JOURNAL OF DERMATOLOGY . vol. 160 , 923 - 923 .

Cichon MA, Papadakis ES, MacKenzie IC, O'Toole EA ( 2009 ) . The role of the receptor tyrosine kinase, Axl, intercellular adhesion and signalling in cancer . BRITISH JOURNAL OF DERMATOLOGY . vol. 160 , 914 - 914 .

Amarasingham EN, Martins VL, Papadakis ES, O'Toole EA ( 2009 ) . The role of type VII collagen in apoptosis in skin . BRITISH JOURNAL OF DERMATOLOGY . vol. 160 , 913 - 914 .

Singh M, Breuer J, Heseltine R, Millar J, Philpott MP, O'Toole EA ( 2009 ) . Varicella-zoster virus infection in skin shows prominent involvement of adnexal stem cell compartments . BRITISH JOURNAL OF DERMATOLOGY . vol. 160 , 904 - 904 .

Thomas AC, Tattersall D, Norgett EE, O'Toole EA, Kelsell DP ( 2009 ) . Premature terminal differentiation and a reduction in specific proteases associated with loss of ABCA12 in Harlequin ichthyosis . Am J Pathol vol. 174 , ( 3 ) 970 - 978 .

O'Toole E ( 2008 ) . Epidermal basement membrane-mesenchymal interactions . EXP DERMATOL vol. 17 , ( 10 ) 880 - 881 .

Majmudar V, O'Toole E, Khorshid M, Harrison A ( 2008 ) . Birt-Hogg-Dube syndrome: a systemic syndrome with initial presentation to dermatologists . BRITISH JOURNAL OF DERMATOLOGY . vol. 159 , 93 - 93 .

O'Toole EA, Deasy P, Watson R ( 2008 ) . Cutis Marmorata Telangiectatica Congenita Associated with a Double Aortic Arch . Pediatric Dermatology vol. 12 , ( 4 ) 348 - 350 .

O'Toole EA, Gormally S, Drumm B, Monaghan H, Watson R ( 2008 ) . Unilateral Beau's Lines in Childhood Reflex Sympathetic Dystrophy . Pediatric Dermatology vol. 12 , ( 3 ) 245 - 247 .

Papadakis ES, Vyas JJ, Storey A, O'Toole EA ( 2008 ) . A role for the receptor tyrosine kinase, Axl, in cutaneous squamous cell carcinoma survival . BRITISH JOURNAL OF DERMATOLOGY . vol. 158 , 883 - 883 .

Papadakis ES, Vyas JJ, Storey A, O'Toole EA ( 2008 ) . A role for the receptor tyrosine kinase, Axl, in squamous cell carcinoma invasion and survival . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 128 , S37 - S37 .

Tattersall D, Thomas AC, O'Toole EA, Kelsell DP ( 2008 ) . Elucidating the role of ABCA12 in harlequin ichthyosis . BRITISH JOURNAL OF DERMATOLOGY . vol. 158 , 890 - 890 .

Neill GW, Harrison WJ, Ikram MS, Williams TDL, Bianchi LS, Nadendla SK, Green JL, Ghali L et al. ( 2008 ) . GLI1 repression of ERK activity correlates with colony formation and impaired migration in human epidermal keratinocytes . Carcinogenesis vol. 29 , ( 4 ) 738 - 746 .

Neill GW, Harrison W, Ikram M, Williams T, Bianchi L, Nadendla S, O'Toole EA, Aberger F et al. ( 2008 ) . GLI1 repression of epidermal growth factor receptor extracellular signal-regulated kinase signalling may account for the poor metastatic potential of basal cell carcinoma . BRITISH JOURNAL OF DERMATOLOGY . vol. 158 , 884 - 884 .

Webber NK, Elston CM, O'Toole EA ( 2008 ) . Generalized pustular psoriasis and cryptogenic organizing pneumonia . Br J Dermatol vol. 158 , ( 4 ) 853 - 854 .

Kelsell DP, Thomas AC, Tattersall D, O'Toole EA ( 2008 ) . Genetic and functional mechanisms in harlequin ichthyosis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 128 , S116 - S116 .

Singh M, Breuer J, Cerio R, Millar J, Philpott MP, O'Toole EA ( 2008 ) . Immunohistochemical study of varicella-zoster virus infection in skin confirms prominent involvement of the follicular epithelium . BRITISH JOURNAL OF DERMATOLOGY . vol. 158 , 892 - 892 .

Martins VL, Vyas JJ, Purdie KJ, Chen M, McGrath JA, Storey A, South AP, O'Toole EA ( 2008 ) . Loss of type VII collagen in squamous cell carcinoma results in increased invasion with disorganized epithelial differentiation and epithelial-mesenchymal transition . BRITISH JOURNAL OF DERMATOLOGY . vol. 158 , 882 - 882 .

Martin VI, Vyas JJ, Chen M, Purdie K, South AP, Storey A, McGrath JA, O'Toole EA ( 2008 ) . Mechanisms of increased invasion of cutaneous squamous cell carcinoma with loss of type VII collagen . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 128 , S37 - S37 .

Singh M, Breuer J, Cerio R, Millar J, Philpott MP, O'Toole EA ( 2008 ) . Varicella zoster virus colocalizes within adnexal stem cell compartments of skin . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 128 , S194 - S194 .

Thomas AC, Sinclair C, Mahmud N, Cullup T, Mellerio JE, Harper J, Dale BA, Turc-Carel C et al. ( 2008 ) . Novel and recurring ABCA12 mutations associated with harlequin ichthyosis: implications for prenatal diagnosis . Br J Dermatol vol. 158 , ( 3 ) 611 - 613 .

Webber N, O'Toole EA, Paige DG, Rosser E ( 2008 ) . Cutaneous features associated with microcephalic osteodysplastic primordial dwarfism type II . Pediatr Dermatol vol. 25 , ( 3 ) 401 - 402 .

O'Toole EA, van Koningsveld R, Chen M, Woodley DT ( 2008 ) . Hypoxia induces epidermal keratinocyte matrix metalloproteinase-9 secretion via the protein kinase C pathway . J Cell Physiol vol. 214 , ( 1 ) 47 - 55 .

Papadakis E, Vyas JJ, O'Toole EA, Storey A ( 2007 ) . A role for the receptor tyrosine kinase, Axl, in cutaneous squamous cell carcinoma survival . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 127 , S96 - S96 .

Neill W, Harrison WJ, Ikram MS, Williams TDL, Green JL, Ghali L, Frischauf AM, O'Toole EA et al. ( 2007 ) . Attenuation of EGFR-ERK signalling by GLI1 highlights a mechanism to promote the epithelial phenotype and may account for the poor metastatic potential of basal cell carcinoma . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 127 , S91 - S91 .

Pourreyron C, Cox G, Mao X, Volz A, Baksh N, Wong T, Fassihi H, Arita K et al. ( 2007 ) . Patients with recessive dystrophic epidermolysis bullosa develop squamous-cell carcinoma regardless of type VII collagen expression . J Invest Dermatol vol. 127 , ( 10 ) 2438 - 2444 .

Man YKS, Trolove C, Tattersall D, Thomas AC, Papakonstantinopoulou A, Patel D, Scott C, Chong J et al. ( 2007 ) . A deafness-associated mutant human connexin 26 improves the epithelial barrier in vitro . J Membr Biol vol. 218 , ( 1-3 ) 29 - 37 .

Majmudar V, Herath D, O'Toole EA, Harrison AP ( 2007 ) . Childhood bullous pemphigoid: a rare disease with management challenges . BRITISH JOURNAL OF DERMATOLOGY . vol. 157 , 126 - 126 .

Cox GA, Pourreyron C, Volz A, O'Toole EA, Chen M, Bruckner-Tuderman L, Salas-Alanis JC, Leigh IM et al. ( 2007 ) . Does the presence or absence of type VII collagen expression in individuals with recessive dystrophic epidermolysis bullosa have implications for the risk of developing squamous cell carcinoma? . BRITISH JOURNAL OF DERMATOLOGY . vol. 157 , 12 - 13 .

Sinclair C, O'Toole EA, Paige D, Mein CA, Kelsell DP ( 2007 ) . A comprehensive survey of 28 candidate genes for atopic dermatitis using a hapTAG approach in a unique Bangladeshi population of East London . BRITISH JOURNAL OF DERMATOLOGY . vol. 156 , 1103 - 1103 .

Wan H, Yuan M, Simpson C, Allen K, Gavins FNE, Ikram MS, Basu S, Baksh N et al. ( 2007 ) . Stem/progenitor cell-like properties of desmoglein 3dim cells in primary and immortalized keratinocyte lines . Stem Cells vol. 25 , ( 5 ) 1286 - 1297 .

van Koningsveld R, Fitchett CJ, Rugg EL, Kelsell DP, O'Toole EA ( 2007 ) . The effect of pachyonychia congenita type 1 mutations in keratinocyte adhesion and desmosome formation and associated signal transduction . BRITISH JOURNAL OF DERMATOLOGY . vol. 156 , 1099 - 1099 .

Martins VL, Vyas JJ, Purdie KJ, Chen M, McGrath JA, Storey A, South AP, O'Toole EA ( 2007 ) . The role of type VII collagen in squamous cell carcinoma invasion in recessive dystrophic epidermolysis bullosa . BRITISH JOURNAL OF DERMATOLOGY . vol. 156 , 1103 - 1104 .

Martins VL, Vyas JJ, Purdie KJ, Chen M, McGrath JA, Storey A, South AP, O'Toole EA ( 2007 ) . Knock-down of type VII collagen in squamous cell carcinoma increases migration and invasion with loss of differentiation . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 127 , S35 - S35 .

Wan H, Yuan M, Simpson C, Allen K, Gavins FN, Ikram MS, Basu S, Baksh N et al. ( 2007 ) . Stem/progenitor cell-like properties of Desmoglein 3dim cells in primary and immortalized keratinocyte lines . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 127 , S66 - S66 .

Thomas AC, Cullup T, Norgett EE, Hill T, Barton S, Dale BA, Sprecher E, Sheridan E et al. ( 2006 ) . ABCA12 is the major harlequin ichthyosis gene . J Invest Dermatol vol. 126 , ( 11 ) 2408 - 2413 .

Sheth N, Bull R, Cerio R, Harwood C, O'Toole E, Paige D, Goldsmith P ( 2006 ) . Fatal erosive lichen planus . Br J Dermatol vol. 155 , ( 5 ) 1075 - 1076 .

Blaydon DC, Ishii Y, O'Toole EA, Unsworth HC, Teh M-T, Rüschendorf F, Sinclair C, Hopsu-Havu VK et al. ( 2006 ) . The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia . Nat Genet vol. 38 , ( 11 ) 1245 - 1247 .

Man S, Unsworth H, Aasen T, Trolove C, Tattersall D, Thomas A, O'Toole E, Navsaria H et al. ( 2006 ) . Connexins have isoform and tissue specific functions and are critical for skin differentiation, migration, wound healing and bacterial invasion . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 126 , 10 - 10 .

Sinclair C, O'Toole E, Leigh I, Paige D, Elbashir H, Stevens H, Booy R, Mein C et al. ( 2006 ) . Filaggrin mutation is not a genetic risk factor for atopic dermatitis in the Bangladeshi population . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 126 , 40 - 40 .

Van Koningsveld R, Fitchett CJ, Rugg EL, O'Toole EA ( 2006 ) . Functional effects of pachyonychia congenita type I mutations on keratinocyte migration and the actin cytoskeleton . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 126 , 3 - 3 .

Pourreyron C, Jones C, Volz A, O'Toole EA, Chen M, Hart IR, Bruckner-Tuderman L, Salis-Alanis JC et al. ( 2006 ) . Patients with recessive dystrophic epidermolysis bullosa develop squamous cell carcinoma regardless of type VII collagen NC1 domain expression . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 126 , 32 - 32 .

Blaydon DC, Ishii Y, O'Toole EA, Teh MT, Hopsu-Havu VK, Moss C, Ruschendorf F, Wajid M et al. ( 2006 ) . R-spondin 4 (RSPO4), a novel secreted protein implicated in Wnt signalling, is mutated in inherited anonychia . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 126 , 31 - 31 .

Vyas JJ, Green J, Proby CM, Storey A, O'Toole EA ( 2006 ) . Signalling mechanisms in squamous cell carcinoma migration and invasion . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 126 , 87 - 87 .

Martins VL, Vyas JJ, Purdie KJ, Chen M, McGrath JA, Storey A, South AP, O'Toole EA ( 2006 ) . Type VII collagen regulates squamous cell carcinoma cell migration and proteinase expression . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 126 , 87 - 87 .

Vyas JJ, Ahmed W, Martins VLC, Storey A, O'Toole EA ( 2006 ) . Axl expression in keratinocytes promotes invasion with degradation of the basement membrane . BRITISH JOURNAL OF DERMATOLOGY . vol. 155 , 243 - 244 .

Fitchett CJ, Van Koningsveld R, Rugg EL, O'Toole EA ( 2006 ) . Functional effects of pachyonychia congenita type I mutations on keratinocyte migration . BRITISH JOURNAL OF DERMATOLOGY . vol. 155 , 235 - 236 .

Thomas AC, Norgett EE, Cullup T, O'Toole EA, Kelsell DP ( 2006 ) . Genetic and functional mechanisms of ABCA12-associated harlequin ichthyosis . BRITISH JOURNAL OF DERMATOLOGY . vol. 155 , 236 - 236 .

Vyas JJ, Proby CM, Storey A, O'Toole EA ( 2006 ) . Signalling mechanisms of squamous cell carcinoma in an in vitro model of squamous cell carcinogenesis . BRITISH JOURNAL OF DERMATOLOGY . vol. 155 , 237 - 237 .

( 2006 ) . Séance conjointe entre la Société Française de Dermatologie Pédiatrique, la Société Française de Dermatologie et la British Society of Paediatric Dermatology . Annales de Dermatologie et de Vénéréologie vol. 133 , ( 6-7 )

Green J, Ikram M, Vyas J, Patel N, Proby CM, Ghali L, Leigh IM, O'Toole EA et al. ( 2006 ) . Overexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumours . Br J Cancer vol. 94 , ( 10 ) 1446 - 1451 .

Rajpopat S, O'Tooele E, Paige D ( 2006 ) . Harlequin ichthyosis: A new understanding . JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY . vol. 54 , AB123 - AB123 .

Common JEA, O'Toole EA, Leigh IM, Thomas A, Griffiths WAD, Venning V, Grabczynska S, Peris Z et al. ( 2005 ) . Clinical and genetic heterogeneity of erythrokeratoderma variabilis . J Invest Dermatol vol. 125 , ( 5 ) 920 - 927 .

Common JEA, Bitner-Glindzicz M, O'Toole EA, Barnes MR, Jenkins L, Forge A, Kelsell DP ( 2005 ) . Specific loss of connexin 26 expression in ductal sweat gland epithelium associated with the deletion mutation del(GJB6-D13S1830) . Clin Exp Dermatol vol. 30 , ( 6 ) 688 - 693 .

Leachman SA, Kaspar RL, Fleckman P, Florell SR, Smith FJD, McLean WHI, Lunny DP, Milstone LM et al. ( 2005 ) . Clinical and pathological features of pachyonychia congenita . J Investig Dermatol Symp Proc . vol. 10 , 3 - 17 .

Lau KG, Hattori Y, Chopra S, O'Toole EA, Storey A, Nagai T, Maitani Y ( 2005 ) . Ultra-deformable liposomes containing bleomycin: in vitro stability and toxicity on human cutaneous keratinocyte cell lines . Int J Pharm vol. 300 , ( 1-2 ) 4 - 12 .

Kelsell DP, Norgett EE, Unsworth H, Teh MT, Cullup T, Mein CA, Dopping-Hepenstal PJ, Kennedy CT et al. ( 2005 ) . Clinical and molecular features of Harlequin ichthyosis . BRITISH JOURNAL OF DERMATOLOGY . vol. 153 , 5 - 5 .

Thein M, Khorshid SM, Cerio R, O'Toole EA ( 2005 ) . Unusual histopathology in cutaneous sarcoidosis mimicking late secondary syphilis . BRITISH JOURNAL OF DERMATOLOGY . vol. 153 , 70 - 70 .

Ismail F, O'Toole EA, McGregor JM, Khorshid SM ( 2005 ) . Unusual distribution of punctate dysplastic keratoses and skin cancers in sunbed users: a report of three cases . Br J Dermatol vol. 152 , ( 6 ) 1374 - 1376 .

Kelsell DP, Norgett EE, Unsworth H, Teh M-T, Cullup T, Mein CA, Dopping-Hepenstal PJ, Dale BA et al. ( 2005 ) . Mutations in ABCA12 underlie the severe congenital skin disease harlequin ichthyosis . Am J Hum Genet vol. 76 , ( 5 ) 794 - 803 .

Di W-L, Gu Y, Common JEA, Aasen T, O'Toole EA, Kelsell DP, Zicha D ( 2005 ) . Connexin interaction patterns in keratinocytes revealed morphologically and by FRET analysis . J Cell Sci vol. 118 , ( Pt 7 ) 1505 - 1514 .

Common JEA, Thomas AC, O'Toole EA, Kelsell DP ( 2005 ) . Evidence for a key role of Connexin 26 in early epidermal differentiation . BRITISH JOURNAL OF DERMATOLOGY . vol. 152 , 855 - 855 .

Fitchett CJ, Rugg EL, Gilfillan N, Leigh IM, O'Toole EA ( 2005 ) . Functional effects of pachyonychia congenita type I mutations on keratinocyte migration and proliferation . BRITISH JOURNAL OF DERMATOLOGY . vol. 152 , 835 - 835 .

Fitchett CJ, Rugg EL, Gilfillan N, Leigh IM, O'Toole EA ( 2005 ) . Functional effects of pachyonychia congenital type I mutations on keratinocyte motility and proliferation . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 124 , A95 - A95 .

Neill GW, Kasper M, Williams T, Ikram M, Ghali L, Green J, Quinn A, Frischauf A et al. ( 2005 ) . Gli1 co-operates with EGFR signalling to induce a neuronal phenotype in keratinocytes . BRITISH JOURNAL OF DERMATOLOGY . vol. 152 , 844 - 844 .

Patel N, Vyas J, Ghali L, Green J, Cerio R, Storey A, O'Toole EA ( 2005 ) . Increased Axl expression in invasive squamous cell carcinoma . BRITISH JOURNAL OF DERMATOLOGY . vol. 152 , 843 - 843 .

Ong C, Di WL, O'Toole EA, Green A, Callard R, Harper J ( 2005 ) . LEKTI is required for skin barrier integrity and acts via the PAR-2 signalling pathway . BRITISH JOURNAL OF DERMATOLOGY . vol. 152 , 851 - 852 .

Vyas J, Ahmed W, Jayazeri M, Marshall JF, Proby CM, Storey A, O'Toole EA ( 2005 ) . Mechanisms of migration and invasion of squamous cell carcinoma in an in vitro model of squamous cell carcinogenesis . BRITISH JOURNAL OF DERMATOLOGY . vol. 152 , 843 - 843 .

Vyas JJ, Ahmed W, Jayazeri M, Baksh N, Marshall JF, Proby CM, Storey A, O'Toole EA ( 2005 ) . Migration and invasion mechanisms in an in vitro model of squamous cell carcinogenesis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 124 , A22 - A22 .

Ong C, O'Toole EA, Ghali L, Malone M, Smith VV, Callard R, Harper JI ( 2004 ) . LEKTI demonstrable by immunohistochemistry of the skin: a potential diagnostic skin test for Netherton syndrome . Br J Dermatol vol. 151 , ( 6 ) 1253 - 1257 .

Ong C, Di WL, Mazereeuw J, Callard R, O'Toole E, Harper J ( 2004 ) . LEKTI, terminal differentiation of keratinocytes and skin barrier formation . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 123 ,

Neill G, Ikram MS, Green JL, Quinn AG, O'Toole E, Philpott MP ( 2004 ) . Gli1 co-operates with EGFR-Sre signalling to induce a fibroblastoid phenotype in primary keratinocytes . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 122 , A17 - A17 .

Ismail FF, Khorshid SM, O'Toole EA, McGregor JM ( 2004 ) . Sunbed related dysplastic keratosis - A report of three cases . JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY . vol. 50 , P122 - P122 .

Jolliffe VM, O'Toole EA, Common JE, Kelsell DP, Yell JA, Paige DG, McKenna KE, Leigh IM ( 2003 ) . Clinical and molecular features of keratitis-ichthyosis-deafness syndrome . BRITISH JOURNAL OF DERMATOLOGY . vol. 149 , 80 - 80 .

O'Toole E, Lyons I ( 2003 ) . Migration and proteolysis in a cell culture model of squamous epidermal carcinogenesis . BRITISH JOURNAL OF DERMATOLOGY . vol. 148 , 858 - 858 .

Eisman S, O'Toole EA, Jones A, Whittaker SJ ( 2003 ) . Granulomatous mycosis fungoides presenting as an acquired ichthyosis . Clin Exp Dermatol vol. 28 , ( 2 ) 174 - 176 .

Common JEA, Di W-L, Davies D, Galvin H, Leigh IM, O'Toole EA, Kelsell DP ( 2003 ) . Cellular mechanisms of mutant connexins in skin disease and hearing loss . Cell Commun Adhes . vol. 10 , 347 - 351 .

Common JEA, Becker D, Di W-L, Leigh IM, O'Toole EA, Kelsell DP ( 2002 ) . Functional studies of human skin disease- and deafness-associated connexin 30 mutations . Biochem Biophys Res Commun vol. 298 , ( 5 ) 651 - 656 .

Hunt SJ, O'toole E, Philips W, Hardman C, Wakelin SH, Walters S ( 2002 ) . A case of childhood sarcoidosis . Clin Exp Dermatol vol. 27 , ( 6 ) 448 - 450 .

Chen M, O'Toole EA, Sanghavi J, Mahmud N, Kelleher D, Weir D, Fairley JA, Woodley DT ( 2002 ) . The epidermolysis bullosa acquisita antigen (type VII collagen) is present in human colon and patients with crohn's disease have autoantibodies to type VII collagen . J Invest Dermatol vol. 118 , ( 6 ) 1059 - 1064 .

O’Toole EA, Mak LL, Guitart J, Woodley DT, Hashimoto T, Amagai M, Chan LS ( 2002 ) . Induction of keratinocyte IL-8 expression and secretion by IgG autoantibodies as a novel mechanism of epidermal neutrophil recruitment in a pemphigus variant . Clinical & Experimental Immunology vol. 119 , ( 1 ) 217 - 224 .

Jean-Baptiste S, O'Toole EA, Chen M, Guitart J, Paller A, Chan LS ( 2002 ) . Expression of eotaxin, an eosinophil-selective chemokine, parallels eosinophil accumulation in the vesiculobullous stage of incontinentia pigmenti . Clin Exp Immunol vol. 127 , ( 3 ) 470 - 478 .

Jones J, O'Toole EA, Rustin MHA, Whittaker SJ ( 2002 ) . Case 1. Systematic lupus erythematosus (SLE) . Clin Exp Dermatol vol. 27 , ( 1 ) 78 - 79 .

O'TOOLE EA, Woodley DT, Yurko MA ( 2002 ) . Phosphorylation of focal adhesion kinase (pp125(FAK)) is increased in human keratinocytes induced to migrate by extracellular matrices . Journal of Cellular Physiology vol. 188 , ( 1 ) 24 - 32 .

O'Toole, Powell, Barnes ( 2001 ) . Jessner's lymphocytic infiltrate and probable discoid lupus erythematosus occurring separately in two sisters . Clinical and Experimental Dermatology vol. 24 , ( 2 ) 90 - 93 .

Orteu CH, Rustin MHA, O'toole E, Sabin C, Salmon M, Poulter LW, Akbar AN ( 2001 ) . The inhibition of cutaneous T cell apoptosis may prevent resolution of inflammation in atopic eczema . Clinical & Experimental Immunology vol. 122 , ( 2 ) 150 - 156 .

O'Toole EA ( 2001 ) . Extracellular matrix and keratinocyte migration . Clin Exp Dermatol vol. 26 , ( 6 ) 525 - 530 .

O'Toole EA, Di WL, Common J, Leigh IM, Kelsell DP ( 2001 ) . Heterogeneity of genetic mutations in erythrokeratodermas . J INVEST DERMATOL vol. 117 , ( 3 ) 797 - 797 .

Yurko MA, O'Toole EA, Woodley DT ( 2001 ) . Phosphorylation of focal adhesion kinase (pp125(FAK)) is increased in human keratinocytes induced to migrate by extracellular matrices . J Cell Physiol vol. 188 , ( 1 ) 24 - 32 .

Eisman S, O'Toole EA, Collis C, Rustin MH ( 2001 ) . Zosteriform Kaposi's sarcoma . Clin Exp Dermatol vol. 26 , ( 5 ) 402 - 404 .

Chen M, O'Toole EA, Muellenhoff M, Medina E, Kasahara N, Woodley DT ( 2000 ) . Development and Characterization of A Recombinant Truncated Type VII Collagen “Minigene” IMPLICATION FOR GENE THERAPY OF DYSTROPHIC EPIDERMOLYSIS BULLOSA* . Journal of Biological Chemistry vol. 275 , ( 32 ) 24429 - 24435 .

Xu L, O’Toole EA, Olivry T, Hernandez C, Peng J, Chen M, Chan LS ( 2000 ) . Molecular cloning of canine bullous pemphigoid antigen 2 cDNA and immunomapping of NC16A domain by canine bullous pemphigoid autoantibodies1This paper was presented in part, as an abstract, at the Annual Meeting of the Society for Investigative Dermatology, April 23–27, 1997, Washington, DC.1 . Biochimica et Biophysica Acta vol. 1500 , ( 1 ) 97 - 107 .

O’Toole EA, Palicharla P, West DP, Woodley DT, Nasca MR ( 1999 ) . Thalidomide Increases Human Keratinocyte Migration and Proliferation . Journal of Investigative Dermatology vol. 113 , ( 5 ) 720 - 724 .

Chen M, O'Toole EA, Li Y-Y, Woodley DT ( 1999 ) . α2β1 Integrin Mediates Dermal Fibroblast Attachment to Type VII Collagen via a 158-Amino-Acid Segment of the NC1 Domain . Experimental Cell Research vol. 249 , ( 2 ) 231 - 239 .

Fishman DA, Kearns A, Chilukuri K, Bafetti LM, O’Toole EA, Georgacopoulos J, Ravosa MJ, Stack MS ( 1999 ) . Metastatic Dissemination of Human Ovarian Epithelial Carcinoma Is Promoted by α2β1-Integrin-Mediated Interaction with Type I Collagen . Invasion and Metastasis vol. 18 , ( 1 ) 15 - 26 .

Chen M, Jones JCR, O'Toole EA, Li Y-Y, Woodley DT, Marinkovich MP ( 1999 ) . NC1 Domain of Type VII Collagen Binds to the β3 Chain of Laminin 5 Via a Unique Subdomain Within the Fibronectin-Like Repeats . Journal of Investigative Dermatology vol. 112 , ( 2 ) 177 - 183 .

O'TOOLE EA, KENNEDY U, NOLAN JJ, YOUNG MM, ROGERS S, BARNES L ( 1999 ) . Necrobiosis lipoidica: only a minority of patients have diabetes mellitus . British Journal of Dermatology vol. 140 , ( 2 ) 283 - 286 .

Xu L, Chen M, Peng J, O’Toole EA, Woodley DT, Chan LS ( 1998 ) . Molecular cloning and characterization of a cDNA encoding canine type VII collagen non-collagenous (NC1) domain, the target antigen of autoimmune disease epidermolysis bullosa acquisita (EBA) . Biochimica et Biophysica Acta vol. 1408 , ( 1 ) 25 - 34 .

Sung C-C, O'Toole EA, Lannutti BJ, Hunt J, O'Gorman M, Woodley DT, Paller AS ( 1998 ) . Integrin α5β1 Expression Is Required for Inhibition of Keratinocyte Migration by Ganglioside GT1b . Experimental Cell Research vol. 239 , ( 2 ) 311 - 319 .

O'Toole EA, Marinkovich MP, Peavey CL, Amieva MR, Furthmayr H, Mustoe TA, Woodley DT ( 1997 ) . Hypoxia increases human keratinocyte motility on connective tissue . Journal of Clinical Investigation vol. 100 , ( 11 ) 2881 - 2891 .

O'Toole EA, Nasca MR, Palicharla P, West DP, Woodley DT ( 1997 ) . Thalidomide increases keratinocyte proliferation and chemokine secretion in vitro . Clinical Pharmacology and Therapeutics vol. 61 , ( 2 )

O’Toole EA, Mooney EE, Walsh JB, Sweeney EC, Barnes L ( 1997 ) . Disseminated herpes zoster in the elderly . Irish Journal of Medical Science vol. 166 , ( 3 ) 141 - 142 .

Chen M, Marinkovich MP, Veis A, Cai X, Rao CN, O'Toole EA, Woodley DT ( 1997 ) . Interactions of the Amino-terminal Noncollagenous (NC1) Domain of Type VII Collagen with Extracellular Matrix Components A POTENTIAL ROLE IN EPIDERMAL-DERMAL ADHERENCE IN HUMAN SKIN* . Journal of Biological Chemistry vol. 272 , ( 23 ) 14516 - 14522 .

O'Toole EA, Marinkovich MP, Hoeffler WK, Furthmayr H, Woodley DT ( 1997 ) . Laminin-5 Inhibits Human Keratinocyte Migration . Experimental Cell Research vol. 233 , ( 2 ) 330 - 339 .

Chen M, Goyal S, Cai X, O'Toole EA, Woodley DT ( 1997 ) . Modulation of type VII collagen (anchoring fibril) expression by retinoids in human skin cells . Biochimica et Biophysica Acta vol. 1351 , ( 3 ) 333 - 340 .

Chen M, Petersen MJ, Li H-L, Cai X-Y, O'Toole EA, Woodley DT ( 1997 ) . Ultraviolet A Irradiation Upregulates Type VII Collagen Expression in Human Dermal Fibroblasts . Journal of Investigative Dermatology vol. 108 , ( 2 ) 125 - 128 .

Chen M, Chan LS, Cai X, O'Toole EA, Sample JC, Woodley DT ( 1997 ) . Development of an ELISA for Rapid Detection of Anti-Type VII Collagen Autoantibodies in Epidermolysis Bullosa Acquisita . Journal of Investigative Dermatology vol. 108 , ( 1 ) 68 - 72 .

Rao CN, Reddy P, Liu Y, O'toole E, Reeder D, Foster DC, Kisiel W, Woodley DT ( 1996 ) . Extracellular Matrix-Associated Serine Protease Inhibitors (Mr33,000, 31,000, and 27,000) Are Single-Gene Products with Differential Glycosylation: cDNA Cloning of the 33-kDa Inhibitor Reveals Its Identity to Tissue Factor Pathway Inhibitor-2 . Archives of Biochemistry and Biophysics vol. 335 , ( 1 ) 82 - 92 .

Cha D, O'Brien P, O'Toole EA, Woodley DT, Hudson LG ( 1996 ) . Enhanced Modulation of Keratinocyte Motility by Transforming Growth Factor-α (TGF-α) Relative to Epidermal Growth Factor (EGF) . Journal of Investigative Dermatology vol. 106 , ( 4 ) 590 - 597 .

O'Toole EA, Stephens R, Young MM, Tanner A, Barnes L ( 1995 ) . Subungual melanoma: A relation to direct injury? . Journal of the American Academy of Dermatology vol. 33 , ( 3 ) 525 - 528 .

Stinson J, O'Toole E, Cooke T, D'Arcy G, Hall M, Barnes L, Feely J ( 1995 ) . Cholesterol and lipoprotein (a) levels in psoriasis . Irish Medical Journal vol. 88 , ( 4 ) 128 - 129 .

Buckley D, Rogers S, O’Connor W, Murphy G, Darby C, O’Moore R, Mulcahy F, Barnes L et al. ( 1994 ) . Annual Jacob Medal Meeting Proceedings of Meeting held 13th May, 1994 . Irish Journal of Medical Science vol. 163 , ( 8 ) 400 - 401 .