Publications:  Prof Eric Parkinson

Houacine S, Kang A, Parkinson EK, Wan H, Fortune F(2020). Induction of p53 in keratinocyte cultures treated with Behçet's patient sera. Journal of Oral Pathology and Medicine vol. 49, (5) 435-442.

Lai SL, Tan ML, Hollows RJ, Robinson M, Ibrahim M, Margielewska S, Parkinson EK, Ramanathan A et al.(2019). Collagen induces a more proliferative, migratory and chemoresistant phenotype in head and neck cancer via DDR1. Cancers vol. 11, (11)

Wan H, Li X, Ahmad U, Huang Y, Uttagomol J, Rehman A, Zhou K, Warnes G et al.(2019). Desmoglein-3 acts as a pro-survival protein by suppressing reactive oxygen species and doming whilst augmenting the tight junctions in MDCK cells. Mechanisms of Ageing and Development

Rehman A, Cai Y, Hünefeld C, Jedli¿ková H, Huang Y, Teck Teh M, Sharif Ahmad U, Uttagomol J et al.(2019). The desmosomal cadherin desmoglein-3 acts as a keratinocyte anti-stress protein via suppression of p53. Cell Death and Disease vol. 10, (10)

Veeramachaneni R, Walker T, Revil T, Weck AD, Badescu D, O'Sullivan J, Higgins C, Elliott L et al.(2019). Analysis of head and neck carcinoma progression reveals novel and relevant stage-specific changes associated with immortalisation and malignancy. Sci Rep vol. 9, (1)

PARKINSON E, JAMES E, Bennett M(2018). The induction of the fibroblast extracellular senescence metabolome is a dynamic process. Scientific Reports

Tan ML, Parkinson EK, Yap LF, Paterson IC (2018). Relationship between autophagy, activation and senescence in normal and cancer-associated human oral fibroblasts. CANCER RESEARCH. vol. 78,

Smith CJ, Caley M, Parkinson EK, O'Toole EA, Pratten J, Yang J, Braun KM (2018). Investigating the differences in the wound healing responses of skin and gingival keratinocytes. BRITISH JOURNAL OF DERMATOLOGY. vol. 178, E416-E416.

Melling GE, Flannery SE, Abidin SA, Clemmens H, Prajapati P, Hinsley EE, Hunt S, Catto JWF et al.(2018). A miRNA-145/TGF-β1 negative feedback loop regulates the cancer-associated fibroblast phenotype. Carcinogenesis vol. 39, (6) 798-807.

Bergmeier LA, Parkinson EK(2018). Future directions of research in the oral mucosa. Oral Mucosa in Health and Disease: A Concise Handbook,

Smith CJ, Caley M, Parkinson EK, O'Toole EA, Pratten J, Yang J (2018). INVESTIGATING THE DIFFERENCES IN THE WOUND HEALING RESPONSES OF SKIN AND GINGIVAL KERATINOCYTES. WOUND REPAIR AND REGENERATION. vol. 26, A30-A31.

James EL, Lane JAE, Michalek RD, Karoly ED, Parkinson EK(2016). Replicatively senescent human fibroblasts reveal a distinct intracellular metabolic profile with alterations in NAD+ and nicotinamide metabolism. Scientific Reports vol. 6, 38489-38489.

Cirillo N, Hassona Y, Celentano A, Lim KP, Manchella S, Parkinson EK, Prime SS(2016). Cancer associated fibroblasts regulate keratinocyte cell-cell adhesion via TGF-ß-dependent pathways in genotype-specific oral cancer. Carcinogenesis

PARKINSON EK(2016). A miR‐335/COX‐2/PTEN axis regulates the secretory phenotype of senescent cancerassociated fibroblasts. Aging

Parkinson EK, James EL, Prime SS(2016). Senescence-Derived Extracellular Molecules as Modulators of Oral Cancer Development: A Mini-Review. Gerontology vol. 62, (4) 417-424.

Prime SS, Cirillo N, Hassona Y, Lambert DW, Paterson IC, Mellone M, Thomas GJ, James ENL et al.(2016). Fibroblast activation and senescence in oral cancer. Journal Of Oral Pathology and Medicine

Rehman A, Ali S, Lone MA, Atif M, Hassona Y, Prime SS, Pitiyage GN, James ELN et al.(2016). Areca nut alkaloids induce irreparable DNA damage and senescence in fibroblasts and may create a favourable environment for tumour progression. Journal of Oral Pathology and Medicine vol. 45, (5) 365-372.

James EL, Michalek RD, Pitiyage GN, De Castro AM, Vignola KS, Jones J, Mohney RP, Karoly ED et al.(2015). Senescent human fibroblasts show increased glycolysis and redox homeostasis with extracellular metabolomes that overlap with those of irreparable DNA damage, aging, and disease. Journal of Proteome Research vol. 14, (4) 1854-1871.

Dale TP, de Castro A, Kuiper NJ, Parkinson EK, Forsyth NR(2015). Immortalisation with hTERT Impacts on Sulphated Glycosaminoglycan Secretion and Immunophenotype in a Variable and Cell Specific Manner. PLoS One vol. 10, (7)

James EL, Parkinson EK(2015). Serum metabolomics in animal models and human disease. Current Opinion in Clinical Nutrition and Metabolic Care vol. 18, (5) 478-483.

Hassona Y, Cirillo N, Heesom K, Parkinson EK, Prime SS(2014). Senescent cancer-associated fibroblasts secrete active MMP-2 that promotes keratinocyte dis-cohesion and invasion. Br J Cancer vol. 111, (6) 1230-1237.

Dale TP, De Castro A, Parkinson EK, Kuiper NJ, Forsyth NR(2014). Immortalisation with hTERT impacts on sulphated glycosaminoglycan secretion and chondrogenic potential in a variable and cell specific manner. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE vol. 8, 366-366.

de Castro A, Minty F, Hattinger E, Wolf R, Parkinson EK(2014). The secreted protein S100A7 (psoriasin) is induced by telomere dysfunction in human keratinocytes independently of a DNA damage response and cell cycle regulators. Longev Healthspan vol. 3,

Nikolakopoulou Z, Nteliopoulos G, Michael-Titus AT, Parkinson EK(2013). Omega-3 polyunsaturated fatty acids selectively inhibit growth in neoplastic oral keratinocytes by differentially activating ERK1/2. Carcinogenesis vol. N/A, Article N/A, 1-38.

Hassona Y, Cirillo N, Lim KP, Herman A, Mellone M, Thomas GJ, Pitiyage GN, Parkinson EK et al.(2013). Progression of genotype-specific oral cancer leads to senescence of cancer-associated fibroblasts and is mediated by oxidative stress and TGF-β. Carcinogenesis vol. 34, (6) 1286-1295.

Nikolakopoulou Z, Shaikh MH, Dehlawi H, Michael-Titus AT, Parkinson EK(2013). The induction of apoptosis in pre-malignant keratinocytes by omega-3 polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) is inhibited by albumin. Toxicol Lett vol. 218, (2) 150-158.

Pitiyage GN, Lim KP, Gemenitzidis E, Teh M-T, Waseem A, Prime SS, Tilakaratne WM, Fortune F et al.(2012). Increased secretion of tissue inhibitors of metalloproteinases 1 and 2 (TIMPs -1 and -2) in fibroblasts are early indicators of oral sub-mucous fibrosis and ageing. J Oral Pathol Med vol. 41, (6) 454-462.

Pitiyage GN, Slijepcevic P, Gabrani A, Chianea YG, Lim KP, Prime SS, Tilakaratne WM, Fortune F et al.(2011). Senescent mesenchymal cells accumulate in human fibrosis by a telomere-independent mechanism and ameliorate fibrosis through matrix metalloproteinases. J Pathol vol. 223, (5) 604-617.

Lim KP, Cirillo N, Hassona Y, Wei WB, Thurlow JK, Cheong SC, Pitiyage G, Parkinson EK et al.(2011). Fibroblast gene expression profile reflects the stage of tumour progression in oral squamous cell carcinoma. J PATHOL vol. 223, (4) 459-469.

Teh M-T, Parkinson EK, Thurlow JK, Liu F, Fortune F, Wan H(2011). A molecular study of desmosomes identifies a desmoglein isoform switch in head and neck squamous cell carcinoma. J Oral Pathol Med vol. 40, (1) 67-76.

Parkinson EK(2010). Senescence as a modulator of oral squamous cell carcinoma development. Oral Oncol vol. 46, (12) 840-853.

Thurlow JK, Peña Murillo CL, Hunter KD, Buffa FM, Patiar S, Betts G, West CML, Harris AL et al.(2010). Spectral clustering of microarray data elucidates the roles of microenvironment remodeling and immune responses in survival of head and neck squamous cell carcinoma. J Clin Oncol vol. 28, (17) 2881-2888.

Gemenetzidis E, Elena-Costea D, Parkinson EK, Waseem A, Wan H, Teh MT(2010). Induction of Human Epithelial Stem/Progenitor Expansion by FOXM1. Cancer Research vol. 70, (22) Article N/A, 9515-9526.

Nikolakopoulou Z, Michael-Titus AT, Parkinson EK (2009). The selective effect of omega-3 polyunsaturated fatty acids on normal and neoplastic oral keratinocyte apoptosis. MOLECULAR CANCER THERAPEUTICS. vol. 8,

Syed ML, Syed S, Minty F, Harrower S, Singh J, Chin A, McLellan DR, Parkinson EK et al.(2009). Gamma tubulin: A promising indicator of recurrence in squamous cell carcinoma of the larynx. OTOLARYNG HEAD NECK vol. 140, (4) 498-504.

Gemenetzidis E, Bose A, Riaz AM, Chaplin T, Young BD, Ali M, Sugden D, Thurlow JK et al.(2009). FOXM1 upregulation is an early event in human squamous cell carcinoma and it is enhanced by nicotine during malignant transformation. PLoS One vol. 4, (3)

Maclntyre A, Brouilette SW, Lamb K, Radhakrishnan K, McGlynn L, Chee MM, Parkinson EK, Freeman D et al.(2008). Association of increased telomere lengths in limited scleroderma, with a lack of age-related telomere erosion. ANN RHEUM DIS vol. 67, (12) 1780-1782.

Minty F, Thurlow JK, Harrison PR, Parkinson EK(2008). Telomere dysfunction in human keratinocytes elicits senescence and a novel transcription profile. Exp Cell Res vol. 314, (13) 2434-2447.

Tilakaratne WM, Iqbal Z, Teh MT, Ariyawardana A, Pitiyage G, Cruchley A, Stewart JE, Hagi-Pavli E et al.(2008). Upregulation of HIF-1 alpha in malignant transformation of oral submucous fibrosis. J ORAL PATHOL MED vol. 37, (6) 372-377.

Lalli A, Tilakaratne WM, Ariyawardana A, Fitchett C, Leigh IM, Hagi-Pavli E, Cruchley AT, Parkinson EK et al.(2008). An altered keratinocyte phenotype in oral submucous fibrosis: correlation of keratin K17 expression with disease severity. J ORAL PATHOL MED vol. 37, (4) 211-220.

McCaul JA, Gordon KE, Minty F, Fleming J, Parkinson EK(2008). Telomere dysfunction is related to the intrinsic radio-resistance of human oral cancer cells. Oral Oncol vol. 44, (3) 261-269.

Parkinson EK, Fitchett C, Cereser B(2008). Dissecting the non-canonical functions of telomerase. Cytogenet Genome Res vol. 122, (3-4) 273-280.

Parkinson EK, Minty F(2007). Anticancer therapy targeting telomeres and telomerase : current status. BioDrugs vol. 21, (6) 375-385.

Hunter KD, Thurlow JK, Fleming J, Drake PJH, Vass JK, Kalna G, Higham DJ, Herzyk P et al.(2006). Divergent routes to oral cancer. Cancer Res vol. 66, (15) 7405-7413.

Pring M, Prime S, Parkinson EK, Paterson I(2006). Dysregulated TGF-beta 1-induced Smad signalling occurs as a result of defects in multiple components of the TGF-beta signalling pathway in human head and neck carcinoma cell lines. INT J ONCOL vol. 28, (5) 1279-1285.

Sedghizadeh PP, Mallery SR, Thompson SJ, Kresty L, Beck FM, Parkinson EK, Biancamano J, Lang JC(2006). Expression of the serine protease Desc1 correlates directly with normal keratinocyte differentiation and inversely with head and neck squamous cell carcinoma progression. HEAD NECK-J SCI SPEC vol. 28, (5) 432-440.

Hunter KD, Parkinson EK, Harrison PR(2005). Profiling early head and neck cancer. Nat Rev Cancer vol. 5, (2) 127-135.

Munro J, Barr NI, Ireland H, Morrison V, Parkinson EK(2004). Histone deacetylase inhibitors induce a senescence-like state in human cells by a p16-dependent mechanism that is independent of a mitotic clock. Exp Cell Res vol. 295, (2) 525-538.

Scott LA, Vass JK, Parkinson EK, Gillespie DAF, Winnie JN, Ozanne BW(2004). Invasion of normal human fibroblasts induced by v-Fos is independent of proliferation, immortalization, and the tumor suppressors p16INK4a and p53. Mol Cell Biol vol. 24, (4) 1540-1559.

Gordon KE, Parkinson EK(2004). Analysis of telomerase activity and telomere function in cancer. Methods Mol Biol vol. 281, 333-348.

Muntoni A, Fleming J, Gordon KE, Hunter K, McGregor F, Parkinson EK, Harrison PR(2003). Senescing oral dysplasias are not immortalized by ectopic expression of hTERT alone without other molecular changes, such as loss of INK4A and/or retinoic acid receptor-beta: but p53 mutations are not necessarily required. Oncogene vol. 22, (49) 7804-7808.

Wootton M, Steeghs K, Watt D, Munro J, Gordon K, Ireland H, Morrison V, Behan W et al.(2003). Telomerase alone extends the replicative life span of human skeletal muscle cells without compromising genomic stability. HUM GENE THER vol. 14, (15) 1473-1487.

Fitzsimmons SA, Ireland H, Barr NI, Cuthbert AP, Going JJ, Newbold RF, Parkinson EK(2003). Human squamous cell carcinomas lose a mortality gene from chromosome 6q14.3 to q15. Oncogene vol. 22, (11) 1737-1746.

Gordon KE, Ireland H, Roberts M, Steeghs K, McCaul JA, MacDonald DG, Parkinson EK(2003). High levels of telomere dysfunction bestow a selective disadvantage during the progression of human oral squamous cell carcinoma. Cancer Res vol. 63, (2) 458-467.

Parkinson EK(2003). Telomerase as a novel and potentially selective target for cancer chemotherapy. Ann Med vol. 35, (7) 466-475.

Bryce SD, Morrison V, Craig NJ, Forsyth NR, Fitzsimmons SA, Ireland H, Cuthbert AP, Newbold RF et al.(2002). A mortality gene(s) for the human adenocarcinoma line HeLa maps to a 130-kb region of human chromosome 4q22-q23. Neoplasia vol. 4, (6) 544-550.

McGregor F, Muntoni A, Fleming J, Brown J, Felix DH, MacDonald DG, Parkinson EK, Harrison PR(2002). Molecular changes associated with oral dysplasia progression and acquisition of immortality: potential for its reversal by 5-azacytidine. Cancer Res vol. 62, (16) 4757-4766.

Forsyth NR, Morrison V, Craig NJ, Fitzsimmons SA, Barr NI, Ireland H, Gordon KE, Dowen S et al.(2002). Functional evidence for a squamous cell carcinoma mortality gene(s) on human chromosome 4. Oncogene vol. 21, (33) 5135-5147.

McCaul JA, Gordon KE, Clark LJ, Parkinson EK(2002). Telomerase inhibition and the future management of head-and-neck cancer. Lancet Oncol vol. 3, (5) 280-288.

Paterson IC, Davies M, Stone A, Huntley S, Smith E, Pring M, Eveson JW, Robinson CM et al.(2002). TGF-beta 1 acts as a tumor suppressor of human malignant keratinocytes independently of Smad 4 expression and ligand-induced G(1) arrest. ONCOGENE vol. 21, (10) 1616-1624.

Snaddon J, Parkinson EK, Craft JA, Bartholomew C, Fulton R(2001). Detection of functional PTEN lipid phosphatase protein and enzyme activity in squamous cell carcinomas of the head and neck, despite loss of heterozygosity at this locus. BRIT J CANCER vol. 84, (12) 1630-1634.

Munro J, Steeghs K, Morrison V, Ireland H, Parkinson EK(2001). Human fibroblast replicative senescence can occur in the absence of extensive cell division and short telomeres. Oncogene vol. 20, (27) 3541-3552.

Paterson IC, Matthews JB, Huntley S, Robinson CM, Fahey M, Parkinson EK, Prime SS(2001). Decreased expression of TGF-beta cell surface receptors during progression of human oral squamous cell carcinoma. J PATHOL vol. 193, (4) 458-467.