Publications: Prof Patricia Munroe

van Duijvenboden S, Nelson CP, Raisi-Estabragh Z, Ramirez J, Orini M, Wang Q, Aung N, Codd V et al. ( 2024 ) . Leucocyte telomere length and conduction system ageing . Heart

Ramírez J, van Duijvenboden S, Orini M, Lambiase PD, Tinker A, Young WJ, Munroe PB ( 2024 ) . Prediction of Atrial and Ventricular Arrhythmias using Multiple Cardiovascular Risk Factor Polygenic Risk Scores . Heart Rhythm

Burns R, Young WJ, Aung N, Lopes LR, Elliott PM, Syrris P, Barriales-Villa R, Sohrabi C et al. ( 2024 ) . Genetic basis of right and left ventricular heart shape . Nature Communications vol. 15 , ( 1 )

Aung N, Nicholls HL, Chahal CAA, Khanji MY, Rauseo E, Chadalavada S, Petersen SE, Munroe PB et al. ( 2024 ) . Prevalence, Cardiac Phenotype, and Outcomes of Transthyretin Variants in the UK Biobank Population . JAMA Cardiology vol. 9 , ( 11 ) 964 - 972 .

Zhou B, Rayner AW, Gregg EW, Sheffer KE, Carrillo-Larco RM, Bennett JE, Shaw JE, Paciorek CJ et al. ( 2024 ) . Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants . The Lancet vol. 404 , ( 10467 ) 2077 - 2093 .

Gurumoorthi M, Hesse K, Asatryan B, Shah R, Dabbagh GS, Wolfe R, Sundar VS, Mohiddin S et al. ( 2024 ) . Abstract 4139238: A Multi-Population-First Approach Leveraging UK Biobank (UKBB) and All of Us (AoU) Datasets Reveals Higher Cardiomyopathy Variant Burden in Individuals with Myocarditis . Circulation . vol. 150 , a4139238 - a4139238 .

Dabbagh GS, Hesse K, Agnihotri R, Kaur G, Gurumoorthi M, Shah R, Asatryan B, Galanti K et al. ( 2024 ) . Abstract 4147050: Genetic Insights into Arrhythmogenic Mitral Valve Prolapse – A Case-Control Study from UK Biobank and NIH All of Us . Circulation vol. 150 , ( Suppl_1 ) a4147050 - a4147050 .

Shah R, Kirkby C, Ives C, Lowe M, Munroe PB, Lambiase PD, Young WJ ( 2024 ) . Can variants of genes associated with familial heart block predict conduction disease in the general population? A UK Biobank study . European Heart Journal vol. 45 , ( Supplement_1 )

Young W, Sanghvi MM, Ramirez J, Orini M, Tinker A, Warren HR, Lambiase PD, Munroe PB ( 2024 ) . Circulating metabolites associate with the QT interval in individuals without prevalent cardiovascular disease . European Heart Journal vol. 45 , ( Supplement_1 )

Rauseo E, Salih A, Cooper J, Abdulkareem M, Chadalavada S, Naderi H, Munroe PB, Aung N et al. ( 2024 ) . Clustering analysis based on clinically available data for improving risk stratification and outcome prediction of hypertension . European Heart Journal . vol. 45 ,

Naderi H, Ramirez J, Van Duijvenboden S, Pujadas ER, Aung N, Wang L, Chamling B, Dorr M et al. ( 2024 ) . Diagnostic and prognostic value of ECG-predicted hypertension mediated left ventricular hypertrophy using machine learning . European Heart Journal . vol. 45 ,

Misghina S, Rauseo E, Barrera CE, Vigmond EJ, Slabaugh G, Aung N, Petersen SE, Munroe PB et al. ( 2024 ) . In-silico insights into personalised therapy selection of anti-arrhythmic drugs and ablation using patient-specific biatrial models for atrial fibrillation . European Heart Journal . Conference: ESC 2024 vol. 45 , ehae666.3504 - ehae666.3504 .

Ramirez J, Martinez JP, Van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB et al. ( 2024 ) . Long-term time-to-ventricular arrhythmic event prediction using a deep learning based model on the electrocardiogram signal . European Heart Journal vol. 45 , ( Supplement_1 )

Sanghvi MM, Young WJ, Chadalavada S, Petersen SE, Aung N, Munroe PB ( 2024 ) . Non-lipid metabolomic biomarkers are associated with adverse cardiac remodelling and cardiovascular outcomes . European Heart Journal . vol. 45 ,

Sanghvi MM, Chadalavada S, Aung N, Munroe PB, Donos N, Petersen SE ( 2024 ) . The association between periodontal disease and coronary artery disease: insights from imaging, observational and genome-wide data . European Heart Journal . vol. 45 ,

Van Duijvenboden S, Nicholson G, Smith-Byrne K, Portas L, Atkins J, Ramirez J, Orini M, Young WJ et al. ( 2024 ) . The genetic architecture of exercise-induced ventricular ectopy . European Heart Journal vol. 45 , ( Supplement_1 )

Asatryan B, Murray B, Tadros R, Rieder M, Shah RA, Sharaf Dabbagh G, Landstrom AP, Dobner S et al. ( 2024 ) . Promise and Peril of a Genotype-First Approach to Mendelian Cardiovascular Disease . Journal of the American Heart Association vol. 13 , ( 21 )

Naderi H, Yang Y-H, Munroe PB, Petersen SE, Westwood M, Aung N ( 2024 ) . Health data science course for clinicians: Time to bridge the skills gap? . Perfusion

Sanghvi MM, Ramírez J, Chadalavada S, Aung N, Munroe PB, Donos N, Petersen SE ( 2024 ) . The Association Between Periodontal Disease and Cardiovascular Disease Insights From Imaging, Observational, and Genetic Data . JACC Advances vol. 3 , ( 10 )

Young WJ, van der Most PJ, Bartz TM, Bos MM, Biino G, Duong T, Foco L, Lominchar JT et al. ( 2024 ) . Genome-Wide Interaction Analyses of Serum Calcium on Ventricular Repolarization Time in 125 393 Participants . Journal of the American Heart Association vol. 13 , ( 17 )

Zhou B, Bennett JE, Wickham AP, Singleton RK, Mishra A, Carrillo-Larco RM, Ikeda N, Jain L et al. ( 2024 ) . General and abdominal adiposity and hypertension in eight world regions: a pooled analysis of 837 population-based studies with 7·5 million participants . The Lancet vol. 404 , ( 10455 ) 851 - 863 .

Gomez EA, De Matteis R, Udomjarumanee P, Team GAHR, Akhtar S, Anwar M, Arciero E, Asgar O et al. ( 2024 ) . An LGR6 frameshift variant abrogates receptor expression on select leukocyte subsets and is associated with viral infections . Blood vol. 144 , ( 4 ) 420 - 434 .

Ramírez J, van Duijvenboden S, Young WJ, Chen Y, Usman T, Orini M, Lambiase PD, Tinker A et al. ( 2024 ) . Fine mapping of candidate effector genes for heart rate . Human Genetics vol. 143 , ( 9-10 ) 1207 - 1221 .

Madrid J, Munroe P, Duijvenboden S, Mincholé A, Ramírez J ( 2024 ) . ECG-based unsupervised clustering in coronary artery disease associates with cardiovascular events . Journal of Electrocardiology vol. 85 , 3 - 4 .

Tsisanova E, Nobles M, Sebastian S, Ng K-E, Thomas A, Weinstein LS, Munroe PB, Tinker A ( 2024 ) . The ric-8b protein (resistance to inhibitors of cholinesterase 8b) is key to preserving contractile function in the adult heart . Journal of Biological Chemistry vol. 300 , ( 7 )

Nicholls HL, Vargas J, Chahal A, Khanji M, Petersen S, Munroe P, Aung N ( 2024 ) . Common and rare variant association study of left and right ventricular phenotypes identifies novel genetic loci and therapeutic targets for heart failure . Conference: European Society of Human Genetics ( Berlin, Germany ) from: 01/06/2024 to: 04/06/2024 ,

Nicholls H, Vargas J, Chahal A, Khanji M, Petersen S, Munroe P, Aung N ( 2024 ) . Common and rare variant association study of left and right ventricular phenotypes identifies novel genetic loci and therapeutic targets for heart failure . Conference: Londomics Symposium from: 20/05/2024 to: 20/05/2024 ,

Ramírez J, Young WJ, van Duijvenboden S, Munroe PB ( 2024 ) . PO-01-089 PREDICTION OF ATRIAL AND VENTRICULAR ARRHYTHMIAS USING MULTIPLE CARDIOVASCULAR RISK FACTOR POLYGENIC RISK SCORES . Heart Rhythm vol. 21 , ( 5 )

Madrid J, van Duijvenboden S, Munroe PB, Minchole A, Ramírez J ( 2024 ) . PO-02-049 ECG-BASED UNSUPERVISED CLUSTERING IN CORONARY ARTERY DISEASE DETECTS AND PREDICTS HEART FAILURE . Heart Rhythm vol. 21 , ( 5 )

Misghina SB, Solis-Lemus JA, Lopez-Barrera CE, Rauseo E, Vigmond EJ, Niederer SA, Aung N, Munroe PB et al. ( 2024 ) . PO-05-033 PATIENT-SPECIFIC BIATRIAL MODELLING FRAMEWORK FOR PREDICTING ATRIAL FIBRILLATION OUTCOMES . Heart Rhythm vol. 21 , ( 5 ) s565 - s566 .

Keaton JM, Kamali Z, Xie T, Vaez A, Williams A, Goleva SB, Ani A, Evangelou E et al. ( 2024 ) . Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits . Nature Genetics vol. 56 , ( 5 ) 778 - 791 .

Lau CE, Manou M, Markozannes G, Ala‐Korpela M, Ben‐Shlomo Y, Chaturvedi N, Engmann J, Gentry‐Maharaj A et al. ( 2024 ) . NMR metabolomic modeling of age and lifespan: A multicohort analysis . Aging Cell vol. 23 , ( 7 )

Breeyear JH, Mautz BS, Keaton JM, Hellwege JN, Torstenson ES, Liang J, Bray MJ, Giri A et al. ( 2024 ) . A new test for trait mean and variance detects unreported loci for blood-pressure variation . American Journal of Human Genetics vol. 111 , ( 5 ) 954 - 965 .

Ganji-Arjenaki M, Kamali Z, Pressure ICOB, Evangelou E, Warren HR, Gao H, Ntritsos G, Dimou N et al. ( 2024 ) . Prioritization of Kidney Cell Types Highlights Myofibroblast Cells in Regulating Human Blood Pressure . Kidney International Reports vol. 9 , ( 6 ) 1849 - 1859 .

Munroe PB, Aung N, Ramírez J ( 2024 ) . Genetic analysis of cardiac dynamic flow volumes identifies loci mapping aortic root size . Nature Genetics vol. 56 , ( 2 ) 197 - 199 .

Guirette M, Lan J, McKeown NM, Brown MR, Chen H, de Vries PS, Kim H, Rebholz CM et al. ( 2024 ) . Genome-Wide Interaction Analysis With DASH Diet Score Identified Novel Loci for Systolic Blood Pressure . Hypertension vol. 81 , ( 3 ) 552 - 560 .

Olczak K, Ahmed F, Munroe PB ( 2024 ) . Chapter 17 Disorders manifesting with systemic hypertension . Genomic and Molecular Cardiovascular Medicine , Elsevier

Sanghvi M, Ramirez J, Petersen S, Aung N, Munroe P ( 2024 ) . Kiosk 11R-TC-05 Investigation of the Modulatory Effect of Physical Activity on Genetic Variants Associated with Left Ventricular Mass . Journal of Cardiovascular Magnetic Resonance vol. 26 ,

Ramírez J, Miguel A, van Duijvenboden S, Orini M, Young WJ, Tinker A, Lambiase PD, Munroe PB et al. ( 2023 ) . A Multilayer CNN Using the ECG, Age and Sex Predicts Ventricular Arrhythmias in the General Population . 2016 Computing in Cardiology Conference (CinC) . Conference: 2023 Computing in Cardiology Conference (CinC) vol. 50 , 1 - 4 .

Madrid J, Munroe PB, van Duijvenboden S, Ramírez J, Mincholé A ( 2023 ) . ECG-Based Unsupervised Clustering in Coronary Artery Disease Associates with Ventricular Arrhythmia . 2016 Computing in Cardiology Conference (CinC) . Conference: 2023 Computing in Cardiology Conference (CinC) vol. 50 , 1 - 4 .

Orini M, van Duijvenboden S, Ramírez J, Young W, Tinker A, Munroe PB, Lambiase PD ( 2023 ) . Ultra-Short Beat-to-Beat Repolarization Variability Predicts Cardiovascular Events in Individuals Without Cardiovascular Disease . 2016 Computing in Cardiology Conference (CinC) . Conference: 2023 Computing in Cardiology Conference (CinC) vol. 50 , 1 - 4 .

Guirette M, Lan J, Mckeown N, Brown MR, Chen H, De Vries PS, Kim H, Rebholz CM et al. ( 2023 ) . Genome-Wide Interaction Analysis with DASH Diet Score Identified Novel Loci for Systolic Blood Pressure . vol. 4 , ( 11-20 )

Ramirez J, Martinez JP, Van Duijvenboden S, Tinker A, Lambiase P, Orini M, Munroe PB, Miguel A ( 2023 ) . Combining hypothesis-driven ECG indices with machine learning improves ventricular arrhythmic risk prediction in a low-risk population . European Heart Journal vol. 44 , ( Supplement_2 )

Orini M, Van Duijvenboden S, Young WJ, Ramirez J, Jones AR, Tinker A, Munroe PB, Lambiase PD ( 2023 ) . Ultra-short heart rate variability over 15 seconds is associated with increased long-term risk of cardiovascular disease . European Heart Journal vol. 44 , ( Supplement_2 )

Lau C-HE, Manou M, Markozannes G, Ala-Korpela M, Shlomo YB, Chaturvedi N, Engmann J, Gentry-Maharaj A et al. ( 2023 ) . NMR metabolomic modelling of age and lifespan: a multi-cohort analysis . vol. 4 , ( 11-20 )

Orini M, van Duijvenboden S, Young WJ, Ramírez J, Jones AR, Hughes AD, Tinker A, Munroe PB et al. ( 2023 ) . Long-term association of ultra-short heart rate variability with cardiovascular events . Scientific Reports vol. 13 , ( 1 )

de las Fuentes L, Schwander KL, Brown MR, Bentley AR, Winkler TW, Sung YJ, Munroe PB, Miller CL et al. ( 2023 ) . Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci . Frontiers in Genetics vol. 14 ,

Willems SM, Ng NHJ, Fernandez J, Fine RS, Wheeler E, Wessel J, Kitajima H, Marenne G et al. ( 2023 ) . Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization . Wellcome Open Research vol. 8 ,

van Duijvenboden S, Ramírez J, Orini M, Aung N, Petersen SE, Doherty A, Tinker A, Munroe PB et al. ( 2023 ) . Prognostic Significance of Different Ventricular Ectopic Burdens During Submaximal Exercise in Asymptomatic UK Biobank Subjects . Circulation vol. 148 , ( 24 ) 1932 - 1944 .

Simon J, Fung K, Raisi-Estabragh Z, Aung N, Khanji MY, Zsarnóczay E, Merkely B, Munroe PB et al. ( 2023 ) . Association between subclinical atherosclerosis and cardiac structure and function—results from the UK Biobank Study . European Heart Journal - Imaging Methods and Practice vol. 1 , ( 2 )

Asatryan B, Shah RA, Dabbagh GS, Landstrom AP, Darbar D, Khanji MY, Lopes LR, van Duijvenboden S et al. ( 2023 ) . Predicted Deleterious Variants in Cardiomyopathy Genes Prognosticate Mortality and Composite Outcomes in the UK Biobank . JACC Heart Failure vol. 12 , ( 5 ) 918 - 932 .

Lagou V, Jiang L, Ulrich A, Zudina L, González KSG, Balkhiyarova Z, Faggian A, Maina JG et al. ( 2023 ) . GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification . Nature Genetics vol. 55 , ( 9 ) 1448 - 1461 .

van Duijvenboden S, Ramírez J, Young WJ, Olczak KJ, Ahmed F, Alhammadi MJAY, Pressure ICOB, Bell CG et al. ( 2023 ) . Integration of genetic fine-mapping and multi-omics data reveals candidate effector genes for hypertension . American Journal of Human Genetics vol. 110 , ( 10 ) 1718 - 1734 .

van de Vegte YJ, Eppinga RN, van der Ende MY, Hagemeijer YP, Mahendran Y, Salfati E, Smith AV, Tan VY et al. ( 2023 ) . Genetic insights into resting heart rate and its role in cardiovascular disease . Nature Communications vol. 14 , ( 1 )

Petersen S, Aung N, Munroe P, Raisi Estabragh Z ( 2023 ) . Association of longer leukocyte telomere length with cardiac size, function, and heart failure . JAMA Cardiology

Rasooly D, Peloso GM, Pereira AC, Dashti H, Giambartolomei C, Wheeler E, Aung N, Ferolito BR et al. ( 2023 ) . Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure . Nature Communications vol. 14 , ( 1 )

Naderi H, Ramirez J, Van Duijvenboden S, Ruiz Pujadas E, Aung N, Wang L, Chahal CAA, Lekadir K et al. ( 2023 ) . Classifying hypertension mediated left ventricular hypertrophy phenotypes from the 12-lead electrocardiogram using machine learning . European Heart Journal - Cardiovascular Imaging vol. 24 , ( Supplement_1 )

Sanghvi MM, Aung N, Ramirez J, Munroe PB, Petersen SE ( 2023 ) . The association between non-lipid metabolomic biomarkers and prognostically important left ventricular phenotypes . European Heart Journal - Cardiovascular Imaging vol. 24 , ( Supplement_1 )

Munroe P ( 2023 ) . Predicting left ventricular hypertrophy from the 12-lead electrocardiogram in the UK Biobank imaging study using machine learning . European Heart Journal – Digital Health

Graham SE, Clarke SL, Wu K-HH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I et al. ( 2023 ) . Author Correction: The power of genetic diversity in genome-wide association studies of lipids . Nature vol. 618 , ( 7965 ) e19 - e20 .

Young WJ, Haessler J, Benjamins J-W, Repetto L, Yao J, Isaacs A, Harper AR, Ramirez J et al. ( 2023 ) . Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease . Nature Communications vol. 14 , ( 1 )

Orini M, van Duijvenboden S, Young WJ, Ramírez J, Jones AR, Tinker A, Munroe PB, Lambiase PD ( 2023 ) . Premature atrial and ventricular contractions detected on wearable-format electrocardiograms and prediction of cardiovascular events . European Heart Journal - Digital Health vol. 4 , ( 2 ) 112 - 118 .

Aung N, Lopes LR, van Duijvenboden S, Harper AR, Goel A, Grace C, Ho CY, Weintraub WS et al. ( 2023 ) . Genome-Wide Analysis of Left Ventricular Maximum Wall Thickness in the UK Biobank Cohort Reveals a Shared Genetic Background With Hypertrophic Cardiomyopathy . Circulation Genomic and Precision Medicine vol. 16 , ( 1 )

Orini M, van Duijvenboden S, Tinker A, Munroe P, Lambiase P ( 2022 ) . Association Between Photoplethysmography Pulse Upslope and Cardiovascular Events in over 170,000 UK Biobank Participants . 2016 Computing in Cardiology Conference (CinC) . Conference: 2022 Computing in Cardiology Conference (CinC) vol. 00 , 1 - 4 .

Orini M, van Duijvenboden S, Ramírez J, Tinker A, Munroe P, Lambiase P ( 2022 ) . Uncoupling Between Heart Rate Variability and Heart Rate During Exercise and Recovery as a Predictor of Cardiovascular Events . 2016 Computing in Cardiology Conference (CinC) . Conference: 2022 Computing in Cardiology Conference (CinC) vol. 498 , 1 - 4 .

Kanoni S, Graham SE, Wang Y, Surakka I, Ramdas S, Zhu X, Clarke SL, Bhatti KF et al. ( 2022 ) . Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis . Genome Biology vol. 23 , ( 1 )

Machlitt-Northen S, Keers R, Munroe PB, Howard DM, Pluess M ( 2022 ) . Polygenic risk scores for schizophrenia and major depression are associated with socio-economic indicators of adversity in two British community samples . Translational Psychiatry vol. 12 , ( 1 )

Sebastian S, Weinstein LS, Ludwig A, Munroe P, Tinker A ( 2022 ) . Slowing Heart Rate Protects Against Pathological Cardiac Hypertrophy . Function vol. 4 , ( 1 )

Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen AU et al. ( 2022 ) . A saturated map of common genetic variants associated with human height . Nature vol. 610 , ( 7933 ) 704 - 712 .

Petersen S, Raisi Estabragh Z, Munroe P ( 2022 ) . Incident clinical and mortality associations of myocardial native T1 in the UK Biobank: A prospective observational study . JACC: Cardiovascular Imaging

Young WJ, Lahrouchi N, Isaacs A, Duong T, Foco L, Ahmed F, Brody JA, Salman R et al. ( 2022 ) . Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways . Nature Communications vol. 13 , ( 1 )

Ramírez J, Kiviniemi A, van Duijvenboden S, Tinker A, Lambiase PD, Junttila J, Perkiömäki JS, Huikuri HV et al. ( 2022 ) . ECG T‐Wave Morphologic Variations Predict Ventricular Arrhythmic Risk in Low‐ and Moderate‐Risk Populations . Journal of the American Heart Association vol. 11 , ( 17 )

Ramdas S, Judd J, Graham SE, Kanoni S, Wang Y, Surakka I, Wenz B, Clarke SL et al. ( 2022 ) . A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids . American Journal of Human Genetics vol. 109 , ( 8 ) 1366 - 1387 .

Ramírez J, Van Duijvenboden S, Young W, Tinker A, Lambiase P, Orini M, Munroe P ( 2022 ) . Prediction of coronary artery disease and major adverse cardiovascular events using clinical and genetic risk scores for cardiovascular risk factors . Atherosclerosis vol. 355 , 3 - 4 .

Ramírez J, van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB ( 2022 ) . Prediction of Coronary Artery Disease and Major Adverse Cardiovascular Events Using Clinical and Genetic Risk Scores for Cardiovascular Risk Factors . Circulation Genomic and Precision Medicine vol. 15 , ( 5 ) e003441 - e003441 .

Machlitt‐Northen S, Keers R, Munroe PB, Howard DM, Trubetskoy V, Pluess M ( 2022 ) . Polygenic scores for schizophrenia and major depression are associated with psychosocial risk factors in children: evidence of gene–environment correlation . Journal of Child Psychology and Psychiatry vol. 63 , ( 10 ) 1140 - 1152 .

Machlitt-Northen S, Keers R, Munroe PB, Howard DM, Pluess M ( 2022 ) . Gene–Environment Correlation over Time: A Longitudinal Analysis of Polygenic Risk Scores for Schizophrenia and Major Depression in Three British Cohorts Studies . Genes vol. 13 , ( 7 )

Shah RA, Asatryan B, Dabbagh GS, Aung N, Khanji MY, Lopes LR, van Duijvenboden S, Holmes A et al. ( 2022 ) . Frequency, Penetrance, and Variable Expressivity of Dilated Cardiomyopathy–Associated Putative Pathogenic Gene Variants in UK Biobank Participants . Circulation vol. 146 , ( 2 ) 110 - 124 .

Raisi-Estabragh Z, McCracken C, Condurache DG, Aung N, Vargas JD, Naderi H, Munroe PB, Neubauer S et al. ( 2022 ) . Corrigendum to: Left atrial structure and function are associated with cardiovascular outcomes independent of left ventricular measures: a UK Biobank CMR study . European Heart Journal - Cardiovascular Imaging vol. 23 , ( 9 ) e331 - e331 .

Petersen S, Aung N, Munroe P ( 2022 ) . Genome-wide association analysis reveals insights into the genetic architecture of right ventricular structure and function . Nature Genetics

Rezaei MJ, Woodward JR, Ramirez J, Munroe P ( 2022 ) . Combination of Isolation Forest, SMOTE and Ensemble Learning for the classification of Atrial Fibrillation and Ventricular Arrhythmia . Conference: 2021 International Conference on Biomedical Innovations and Applications (BIA) vol. 1 , 45 - 50 .

Kelly TN, Sun X, He KY, Brown MR, Taliun SAG, Hellwege JN, Irvin MR, Mi X et al. ( 2022 ) . Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension . Hypertension vol. 79 , ( 8 ) 1656 - 1667 .

Naderi H, Ramírez J, Van Duijvenboden S, Aung N, Fung K, Young W, Petersen S, Munroe P ( 2022 ) . PREDICTING THE PATTERN OF ANATOMICAL LEFT VENTRICULAR HYPERTROPHY USING ELECTROPHYSIOLOGICAL BIOMARKERS FROM THE ECG QRS COMPLEX IN HYPERTENSIVE INDIVIDUALS FROM UK BIOBANK . Journal of Hypertension . vol. 40 ,

Shah R, Asatryan B, Dabbagh GS, Khanji M, van Duijvenboden S, Muser D, Landstrom AP, Semsarian C et al. ( 2022 ) . EN-571-02 SCREENING FOR PUTATIVE PATHOGENIC VARIANTS IN DILATED CARDIOMYOPATHY GENES IDENTIFIES EARLY DISEASE AND PREDICTS MORTALITY . Heart Rhythm vol. 19 , ( 5 ) s101 - s102 .

Calabrese C, Pyle A, Griffin H, Coxhead J, Hussain R, Braund PS, Li L, Burgess A et al. ( 2022 ) . Heteroplasmic mitochondrial DNA variants in cardiovascular diseases . PLOS Genetics vol. 18 , ( 4 )

Jepson RE, Warren H, Wallace MD, Syme HM, Elliott J, Munroe PB ( 2022 ) . First genome-wide association study investigating blood pressure and renal traits in domestic cats . Scientific Reports vol. 12 , ( 1 )

Taylor-Bateman V, Gill D, Georgakis MK, Malik R, Munroe P, Traylor M, Evangelou E, Warren HR et al. ( 2022 ) . Cardiovascular Risk Factors and MRI Markers of Cerebral Small Vessel Disease . Neurology vol. 98 , ( 4 ) e343 - e351 .

Petersen S, Aung N, Khanji M, Fung K, Raisi-Estabragh Z, Munroe P ( 2022 ) . Light to moderate coffee consumption is associated with lower risk of death: a UK Biobank study . European Journal of Preventive Cardiology

Trompet S, Postmus I, Warren HR, Noordam R, Smit RAJ, Theusch E, Li X, Arsenault B et al. ( 2022 ) . The Pharmacogenetics of Statin Therapy on Clinical Events: No Evidence that Genetic Variation Affects Statin Response on Myocardial Infarction . Frontiers in Pharmacology vol. 12 ,

Naderi H, Ramirez J, van Duijvenboden S, Ruiz Pujadas E, Wang L, Lekadir K, Petersen S, Munroe P ( 2022 ) . Classifying hypertension mediated left ventricular hypertrophy patterns from the electrocardiogram using machine learning . JOURNAL OF HUMAN HYPERTENSION . vol. 36 , 4 - 4 .

Warren H, Keaton J, Kamali Z, Vaez A, Xie T, Ani A, Evangelou E, Levy D et al. ( 2022 ) . Genome-wide analysis in over 1 million individuals reveals over 2,000 independent genetic signals for blood pressure . JOURNAL OF HUMAN HYPERTENSION . vol. 36 , 7 - 8 .

Olczak K, Aziz Q, Sebastian S, Rajeeve V, Otunsola R, Tinker A, Munroe P ( 2022 ) . Investigating the potential role of R-Ras in blood pressure control . JOURNAL OF HUMAN HYPERTENSION . vol. 36 , 2 - 3 .

Olczak KJ, Aziz Q, Sebastian S, Tinker A, Munroe PB ( 2022 ) . Investigating the potential role of the small GTPase R-Ras in mechanisms of blood pressure control . ACTA PHYSIOLOGICA . vol. 236 , 543 - 543 .

Ramirez J, van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB ( 2022 ) . Prediction of coronary artery disease: Do risk factor genetic risk scores add value? . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 30 , 188 - 189 .

Young WJ, Munroe PB, Tereshchenko L ( 2022 ) . Trans-ancestry GWAS of 118,780 individuals reveals biological mechanisms underlying the spatial QRS-T angle, a marker of arrhythmogenesis . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 30 , 599 - 599 .

Raisi-Estabragh Z, Harvey NC, Munroe P ( 2021 ) . Novel determinants of Cardiovascular disease: a population approach .

Raisi-Estabragh Z, Jaggi A, Gkontra P, McCracken C, Aung N, Munroe PB, Neubauer S, Harvey NC et al. ( 2021 ) . Cardiac Magnetic Resonance Radiomics Reveal Differential Impact of Sex, Age, and Vascular Risk Factors on Cardiac Structure and Myocardial Tissue . Frontiers in Cardiovascular Medicine vol. 8 ,

Petersen S, Munroe P, Aung N, Raisi-Estabragh Z ( 2021 ) . Left atrial structure and function are associated with cardiovascular outcomes independent of left ventricular measures: a UK Biobank CMR study . European Heart Journal: Cardiovascular Imaging

Graham SE, Clarke SL, Wu K-HH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I et al. ( 2021 ) . The power of genetic diversity in genome-wide association studies of lipids . Nature vol. 600 , ( 7890 ) 675 - 679 .

Shah R, Asatryan B, Dabbagh GS, Aung N, Khanji MY, Lopes LR, van Duijvenboden S, Holmes A et al. ( 2021 ) . The Frequency, Penetrance and Variable Expressivity of Dilated Cardiomyopathy-Associated Putative Pathogenic Gene Variants in UK Biobank Participants .

Fung K, Biasiolli L, Hann E, Lukaschuk E, Ramírez J, van Duijvenboden S, Aung N, Paiva JM et al. ( 2021 ) . 9 Identification of thirty novel loci for cardiovascular magnetic resonance derived aortic distensibility in the UK Biobank . Heart . Conference: BSCMR 2021 vol. 107 , a6 - a8 .

Simon J, Fung K, Raisi-Estabragh Z, Aung N, Khanji MY, Kolossvary M, Merkely B, Munroe PB et al. ( 2021 ) . Association of daily coffee consumption with cardiovascular health – results from the UK Biobank . European Heart Journal vol. 42 , ( Supplement_1 )

McDonough CW, Warren HR, Jack JR, Motsinger‐Reif AA, Armstrong ND, Bis JC, House JS, Singh S et al. ( 2021 ) . Adverse Cardiovascular Outcomes and Antihypertensive Treatment: A Genome‐Wide Interaction Meta‐Analysis in the International Consortium for Antihypertensive Pharmacogenomics Studies . Clinical Pharmacology & Therapeutics vol. 110 , ( 3 ) 723 - 732 .

Young W, Isaacs A, Lahrouchi N, Mifsud B, Munroe PB, Newton-Cheh CH, Sotoodehnia N, group OTCEW ( 2021 ) . B-011-01 TRANS-ANCESTRY GWAS OF 252,730 INDIVIDUALS IDENTIFIES 114 NOVEL LOCI ASSOCIATED WITH THE QT INTERVAL . Heart Rhythm vol. 18 , ( 8 )

Young W, Isaacs A, Lahrouchi N, Mifsud B, Munroe PB, Newton-Cheh CH, Sotoodehnia N, group OTCEW ( 2021 ) . B-AB13-01 TRANS-ANCESTRY GWAS OF 252,730 INDIVIDUALS IDENTIFIES 114 NOVEL LOCI ASSOCIATED WITH THE QT INTERVAL . Heart Rhythm vol. 18 , ( 8 )

van Duijvenboden S, Ramírez J, Young WJ, Orini M, Mifsud B, Tinker A, Lambiase PD, Munroe PB ( 2021 ) . Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders . Human Molecular Genetics vol. 30 , ( 24 ) 2513 - 2523 .

Olczak KJ, Taylor‐Bateman V, Nicholls HL, Traylor M, Cabrera CP, Munroe PB ( 2021 ) . Hypertension genetics past, present and future applications . Journal of Internal Medicine vol. 290 , ( 6 ) 1130 - 1152 .

Petersen S, Munroe P, Pugliese F, Lee A, Raisi-Estabragh Z ( 2021 ) . Automated quality-controlled cardiovascular magnetic resonance pericardial fat quantification using a convolutional neural network in the UK Biobank . Frontiers in Cardiovascular Medicine

Ramírez J, van Duijvenboden S, Young WJ, Orini M, Jones AR, Lambiase PD, Munroe PB, Tinker A ( 2021 ) . Analysing electrocardiographic traits and predicting cardiac risk in UK biobank . JRSM Cardiovascular Disease vol. 10 ,

Raisi-Estabragh Z, Martineau A, Curtis E, Moon R, Darling A, Lanham-New S, Ward K, Cooper C et al. ( 2021 ) . Vitamin D and coronavirus disease 2019 (COVID-19): rapid evidence review . Aging Clinical and Experimental Research

van Duijvenboden S, Ramirez J, Orini M, Tinker A, Munroe P, Lambiase P ( 2021 ) . 85 Prognostic value of premature ventricular complexes during exercise stress testing in 56,000 individuals without known structural heart disease from UK biobank: is a single ectopic prognostic? . Heart . Conference: Cardiac rhythm management vol. 107 , a68 - a68 .

Young W, Warren H, Mook-Kanamori D, Ramirez J, van Duijvenboden S, Orini M, Tinker A, van Heemst D et al. ( 2021 ) . BS8 Genetically-determined serum calcium levels influence markers of ventricular repolarisation: a mendelian randomisation study . Heart . Conference: Basic science vol. 107 , a159 - a160 .

Chen J, Spracklen CN, Marenne G, Varshney A, Corbin LJ, Luan J, Willems SM, Wu Y et al. ( 2021 ) . The trans-ancestral genomic architecture of glycemic traits . Nature Genetics vol. 53 , ( 6 ) 840 - 860 .

Manandhar I, Alimadadi A, Aryal S, Munroe P, Joe B, Cheng X ( 2021 ) . Machine Learning of Gut Microbiome Composition for Diagnostic Classification of Inflammatory Bowel Diseases . The FASEB Journal vol. 35 , ( S1 )

Raisi-Estabragh Z, Mccracken C, Gkontra P, Jaggi A, Ardissino M, Cooper J, Biasiolli L, Aung N et al. ( 2021 ) . Higher consumption of red and processed meat is associated with adverse cardiovascular magnetic resonance morpho-functional phenotypes: A study of 19,408 UK Biobank participants . European Journal of Preventive Cardiology . vol. 28 ,

Moksnes MR, Røsjø H, Richmond A, Lyngbakken MN, Graham SE, Hansen AF, Wolford BN, Taliun SAG et al. ( 2021 ) . Genome-wide association study of cardiac troponin I in the general population . Human Molecular Genetics vol. 30 , ( 21 ) 2027 - 2039 .

Petersen S, Munroe P, Aung N, Raisi-Estabragh Z ( 2021 ) . Associations of Meat and Fish Consumption With Conventional and Radiomics Cardiovascular Magnetic Resonance Phenotypes in the UK Biobank . Frontiers of Cardiovascular Medicine

Rezaei MJ, Woodward JR, Ramírez J, Munroe P ( 2021 ) . A Novel Two-Stage Heart Arrhythmia Ensemble Classifier . Computers vol. 10 , ( 5 )

Young WJ, Warren HR, Mook-Kanamori DO, Ramírez J, van Duijvenboden S, Orini M, Tinker A, van Heemst D et al. ( 2021 ) . Genetically Determined Serum Calcium Levels and Markers of Ventricular Repolarization . Circulation Genomic and Precision Medicine vol. 14 , ( 3 )

Wang H, Noordam R, Cade BE, Schwander K, Winkler TW, Lee J, Sung YJ, Bentley AR et al. ( 2021 ) . Multi-ancestry genome-wide gene–sleep interactions identify novel loci for blood pressure . Molecular Psychiatry vol. 26 , ( 11 ) 6293 - 6304 .

Petersen S, Munroe P, Aung N ( 2021 ) . Prevalence of hypertrophic cardiomyopathy in the UK Biobank population . JAMA Cardiology

Petersen S ( 2021 ) . Women with diabetes are at increased relative risk of heart failure compared to men: Insights from UK Biobank . Frontiers in Cardiovascular Medicine

Warren H, Garofalidou T, Singh S, Melander O, Hiltunen T, Glorioso N, Cooper-Dehoff R, Dominiczak A et al. ( 2021 ) . GENOME-WIDE ASSOCIATION STUDY FOR PHARMACOGENETIC RESPONSE OF BLOOD PRESURE TO BETA BLOCKER AND CALCIUM CHANNEL BLOCKER DRUGS . Journal of Hypertension vol. 39 , ( Supplement 1 ) e258 - e259 .

Warren H, Traylor M, Garofalidou T, Ng FL, Gupta A, Sever P, Caulfield M, Munroe P ( 2021 ) . HYPERTENSIVE PATIENTS WITH GREATER GENETIC RISK RESPOND LESS EFFECTIVELY TO TREATMENT AND ARE MORE LIKELY TO BE TREATMENT RESISTANT . Journal of Hypertension vol. 39 , ( Supplement 1 )

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Sebastian S, Nobles M, Tsisanova E, Ludwig A, Munroe PB, Tinker A ( 2021 ) . The role of resistance to inhibitors of cholinesterase 8b in the control of heart rate . Physiological Genomics vol. 53 , ( 4 ) 150 - 159 .

Raisi-Estabragh Z, McCracken C, Cooper J, Fung K, Paiva J, Khanji M, Rauseo E, Biasiolli L et al. ( 2021 ) . Adverse cardiovascular magnetic resonance phenotypes are associated with greater likelihood of incident coronavirus disease 2019: Findings from the UK Biobank . Aging Clinical and Experimental Research

Mensah-Kane J, Schmidt AF, Hingorani AD, Finan C, Chen Y, van Duijvenboden S, Orini M, Lambiase PD et al. ( 2021 ) . No Clinically Relevant Effect of Heart Rate Increase and Heart Rate Recovery During Exercise on Cardiovascular Disease: A Mendelian Randomization Analysis . Frontiers in Genetics vol. 12 ,

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Manandhar I, Alimadadi A, Aryal S, Munroe PB, Joe B, Cheng X ( 2021 ) . Gut microbiome-based supervised machine learning for clinical diagnosis of inflammatory bowel diseases . Am J Physiol Gastrointest Liver Physiol

Lagou V, Mägi R, Hottenga J-J, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D et al. ( 2021 ) . Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability . Nature Communications vol. 12 , ( 1 )

Magavern EF, Warren HR, Ng FL, Cabrera CP, Munroe PB, Caulfield MJ ( 2021 ) . An Academic Clinician’s Road Map to Hypertension Genomics . Hypertension vol. 77 , ( 2 ) 284 - 295 .

Raisi-Estabragh Z, Biasiolli L, Cooper J, Aung N, Fung K, Paiva J, Sanghvi M, Thomson R et al. ( 2021 ) . ASSOCIATIONS BETWEEN BONE AND VASCULAR HEALTH IN THE UK BIOBANK . OSTEOPOROSIS INTERNATIONAL . vol. 32 , S41 - S41 .

Ramirez J, van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB ( 2021 ) . Prediction of Coronary Artery Disease using Traditional and Genetic Risk Scores for Cardiovascular Risk Factors . GENETIC EPIDEMIOLOGY . vol. 45 , 783 - 783 .

Young WJ, Srinivasan N, Tinker A, Munroe PB, Lambiase PD, Orini M ( 2020 ) . Comparisons of the Spatial QRS-T Angle With Intra-cardiac Markers of Depolarization and Repolarization . 2016 Computing in Cardiology Conference (CinC) . Conference: 2020 Computing in Cardiology Conference (CinC) vol. 00 , 1 - 4 .

van Duijvenboden S, Ramírez J, Young WJ, Tinker A, Munroe PB, Lambiase PD, Orini M ( 2020 ) . Evaluating the Impact of Physiological Variability in Genome-Wide Association Studies of Resting Heart Rate . 2016 Computing in Cardiology Conference (CinC) . Conference: 2020 Computing in Cardiology Conference (CinC) vol. 00 , 1 - 4 .

Aung N, Young WJ, van Duijvenboden S, Ramírez J, Petersen SE, Munroe PB ( 2020 ) . Genetic Architecture of Quantitative Cardiovascular Traits: Blood Pressure, ECG and Imaging Phenotypes . 2016 Computing in Cardiology Conference (CinC) . Conference: 2020 Computing in Cardiology Conference (CinC) vol. 00 , 1 - 4 .

Ramírez J, van Duijvenboden S, Tinker A, Lambiase PD, Munroe PB, Orini M ( 2020 ) . Sex Differences in the Morphology of RR-Matched T-waves . 2016 Computing in Cardiology Conference (CinC) . Conference: 2020 Computing in Cardiology Conference (CinC) vol. 00 , 1 - 4 .

Young WJ, Ramírez J, van Duijvenboden S, Tinker A, Lambiase PD, Munroe PB, Orini M ( 2020 ) . Will Genetic Data Significantly Change Cardiovascular Risk Prediction in Daily Practice? . 2016 Computing in Cardiology Conference (CinC) . Conference: 2020 Computing in Cardiology Conference (CinC) vol. 00 , 1 - 4 .

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Aung N, Sanghvi M, Piechnik SK, Naubauer S, Munroe P, Petersen S ( 2020 ) . The effect of lipids on the left ventricle: a Mendelian randomization study . JACC - Journal of the American College of Cardiology vol. 76 , ( 21 )

Aung N, Khanji MY, Munroe PB, Petersen SE ( 2020 ) . Causal Inference for Genetic Obesity, Cardiometabolic Profile and COVID-19 Susceptibility: A Mendelian Randomization Study . Frontiers in Genetics vol. 11 ,

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García-González J, Ramírez J, Howard DM, Brennan CH, Munroe PB, Keers R ( 2020 ) . The effects of polygenic risk for psychiatric disorders and smoking behaviour on psychotic experiences in UK Biobank . Translational Psychiatry vol. 10 , ( 1 )

Raisi‐Estabragh Z, Biasiolli L, Cooper J, Aung N, Fung K, Paiva JM, Sanghvi MM, Thomson RJ et al. ( 2020 ) . Poor Bone Quality is Associated With Greater Arterial Stiffness: Insights From the UK Biobank . Journal of Bone and Mineral Research vol. 36 , ( 1 ) 90 - 99 .

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Patel V, Asatryan B, Siripanthong B, Munroe PB, Tiku-Owens A, Lopes LR, Khanji MY, Protonotarios A et al. ( 2020 ) . State of the Art Review on Genetics and Precision Medicine in Arrhythmogenic Cardiomyopathy . International Journal of Molecular Sciences vol. 21 , ( 18 )

Alimadadi A, Manandhar I, Aryal S, Munroe PB, Joe B, Cheng X ( 2020 ) . Machine learning-based classification and diagnosis of clinical cardiomyopathies . Physiol Genomics vol. 52 , ( 9 ) 391 - 400 .

Cheng X, Alimadadi A, Manandhar I, Aryal S, Munroe PB, Joe B ( 2020 ) . Abstract P051: Application Of Artificial Intelligence In Transcriptome-based Diagnosis Of Cardiomyopathies . Hypertension vol. 76 , ( Suppl_1 )

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van Duijvenboden S, Ramírez J, Young WJ, Mifsud B, Orini M, Tinker A, Munroe PB, Lambiase PD ( 2020 ) . Genetic Basis and Prognostic Value of Exercise QT Dynamics . Circulation Genomic and Precision Medicine vol. 13 , ( 4 ) e002774 - e002774 .

Raisi-Estabragh Z, McCracken C, Bethell MS, Cooper J, Cooper C, Caulfield MJ, Munroe PB, Harvey NC et al. ( 2020 ) . Greater risk of severe COVID-19 in non-White ethnicities is not explained by cardiometabolic, socioeconomic, or behavioural factors, or by 25(OH)-vitamin D status: study of 1,326 cases from the UK Biobank .

Raisi-Estabragh Z, Cooper J, Judge R, Khanji M, Munroe P, Cooper C, Harvey NC, Petersen S ( 2020 ) . Age, sex and disease-specific associations between resting heart rate and cardiovascular mortality in the UK BIOBANK . PLoS One

Raisi-Estabragh Z, Kenawy AAM, Aung N, Cooper J, Munroe PB, Harvey NC, Petersen SE, Khanji MY ( 2020 ) . Variation in left ventricular cardiac magnetic resonance normal reference ranges: systematic review and meta-analysis . European Heart Journal - Cardiovascular Imaging vol. 22 , ( 5 ) 494 - 504 .

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Ramírez J, van Duijvenboden S, Young WJ, Orini M, Lambiase PD, Munroe PB, Tinker A ( 2020 ) . Common Genetic Variants Modulate the Electrocardiographic Tpeak-to-Tend Interval . American Journal of Human Genetics vol. 106 , ( 6 ) 764 - 778 .

de las Fuentes L, Sung YJ, Noordam R, Winkler T, Feitosa MF, Schwander K, Bentley AR, Brown MR et al. ( 2020 ) . Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci . Molecular Psychiatry

Nicholls HL, John CR, Watson DS, Munroe PB, Barnes MR, Cabrera CP ( 2020 ) . Reaching the End-Game for GWAS: Machine Learning Approaches for the Prioritization of Complex Disease Loci . Frontiers in Genetics vol. 11 ,

Alimadadi A, Aryal S, Manandhar I, Munroe PB, Joe B, Cheng X ( 2020 ) . Artificial intelligence and machine learning to fight COVID-19 . Physiological Genomics vol. 52 , ( 4 ) 200 - 202 .

Fung K, Biasiolli L, Hann E, Ramirez J, Lukaschuk E, Aung N, Paiva J, Werys K et al. ( 2019 ) . 3.2 First Genome-Wide Association Study of Cardiovascular Magnetic Resonance Derived Aortic Distensibility Reveals 7 Loci . Artery Research . vol. 25 , s21 - s22 .

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Alimadadi A, Munroe PB, Joe B, Cheng X ( 2020 ) . Meta-analysis of dilated cardiomyopathy using cardiac rna-seq transcriptomic datasets . Genes vol. 11 , ( 1 )

Garofalidou T, Munroe PB ( 2020 ) . Chapter 11 Molecular pathophysiology of systemic hypertension . Clinical Molecular Medicine , Elsevier

Cabrera CP, Pazoki R, Giri A, Hellwege JN, Evangelou E, Ramirez J, Wain LV, Tzoulaki I et al. ( 2020 ) . Multi-trait genome-wide association analysis of blood pressure identifies 45 additional loci . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 28 , 105 - 105 .

García-González J, Ramírez J, Howard DM, Brennan CH, Munroe PB, Keers R ( 2019 ) . The effects of polygenic risk for psychiatric disorders and smoking behaviour on psychotic experiences in UK Biobank .

Noordam R, Bos MM, Wang H, Winkler TW, Bentley AR, Kilpeläinen TO, de Vries PS, Sung YJ et al. ( 2019 ) . Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration . Nature Communications vol. 10 , ( 1 )

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Timasheva Y, Zudina L, Balkhiyarova Z, Kaakinen M, Munroe P, Prokopenko I ( 2019 ) . P4411Analysis of cardiometabolic traits highlights shared biological pathways . European Heart Journal vol. 40 , ( Supplement_1 )

Teumer A, Trenkwalder T, Kessler T, Jamshidi Y, van den Berg ME, Kaess B, Nelson CP, Bastiaenen R et al. ( 2019 ) . KCND3 potassium channel gene variant confers susceptibility to electrocardiographic early repolarization pattern . JCI insight

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Munroe PB, Ramírez J, van Duijvenboden S ( 2019 ) . Resting Heart Rate and Type 2 Diabetes A Complex Relationship in Need of Greater Understanding ∗ . Journal of the American College of Cardiology vol. 74 , ( 17 ) 2175 - 2177 .

Petersen S, Munroe P, Aung N, Fung K, Vargas J, Yang C, Cabrera CP, Warren H et al. ( 2019 ) . Genome-wide analysis of left ventricular image-derived phenotypes identifies fourteen loci associated with cardiac morphogenesis and heart failure development . Circulation

Noordam R, Young WJ, Munroe PB ( 2019 ) . Electrolytes and electrophysiology: What's next? . Aging vol. 11 , ( 18 ) 7329 - 7330 .

Iniesta R, Campbell D, Venturini C, Faconti L, Singh S, Irvin MR, Cooper-DeHoff RM, Johnson JA et al. ( 2019 ) . Gene Variants at Loci Related to Blood Pressure Account for Variation in Response to Antihypertensive Drugs Between Black and White Individuals . Hypertension vol. 74 , ( 3 ) 614 - 622 .

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Cabrera CP, Ng F, Nicholls HL, Gupta A, Barnes MR, Munroe PB, Caulfield MJ ( 2019 ) . Over 1000 genetic loci influencing blood pressure with multiple systems and tissues implicated . Human Molecular Genetics vol. 28 , ( R2 ) R151 - R161 .

Thomas AM, Cabrera CP, Finlay M, Lall K, Nobles M, Schilling RJ, Wood K, Mein CA et al. ( 2019 ) . Differentially expressed genes for atrial fibrillation identified by RNA sequencing from paired human left and right atrial appendages . Physiol Genomics vol. 51 , ( 8 ) 323 - 332 .

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Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N et al. ( 2018 ) . Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits . Nat Genet vol. 50 , ( 12 ) 1755 - 1755 .

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van Duijvenboden S, Ramírez J, Orini M, Tinker A, Munroe PB, Lambiase PD ( 2018 ) . 2QT interval and exercise qt dynamics from 58,852 individuals in UK biobank predict ventricular arrhythmias and heart failure . EP Europace vol. 20 , ( suppl_4 ) iv1 - iv1 .

Bastiaenen R, Nolte IM, Munroe PB, Riese H, Nelson C, O'Connor H, Gang Y, Warren HR et al. ( 2018 ) . The narrow-sense and common single nucleotide polymorphism heritability of early repolarization . International Journal of Cardiology vol. 279 , 135 - 140 .

Pärn K, Pirinen M, Kals M, Mägi R, Salomaa V, Boehnke M, Hall I, Stitziel N et al. ( 2018 ) . Differences in the commonly used genotype imputation algorithms and their imputation accuracy estimates . Conference: 2018 IEEE 14th International Conference on e-Science (e-Science)293 - 294 .

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Munroe PB, Jahangir SNS, Caulfield MJ ( 2018 ) . Genetics and Genomics of Systemic Hypertension . Cardiovascular Genetics and Genomics , Springer Nature

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Munroe PB, Warren HR ( 2018 ) . Chapter 5 Hypertension . Genomic and Precision Medicine , Elsevier

Munroe PB, Warren HR ( 2018 ) . Hypertension . Genomic and Precision Medicine: Cardiovascular Disease: Third Edition ,

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Munroe PB, Johnson T ( 2013 ) . Chapter 44 Hypertension . Genomic and Personalized Medicine , Elsevier

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Xue MZ, Wallace C, Dobson R, Garcia E, Kazeem G, Gardener G, Needham E, Mattu R et al. ( 2005 ) . Variants and haplotypes of the angiotensinogen gene are associated with hypertension in the Caerphilly Prospective Study . HYPERTENSION . vol. 46 , 904 - 904 .

Surtees PG, Wainwright NWJ, Willis-Owen SAG, Luben R, Day NE, Flint J ( 2005 ) . Social Adversity, the Serotonin Transporter (5-HTTLPR) Polymorphism and Major Depressive Disorder . Biological Psychiatry vol. 59 , ( 3 ) 224 - 229 .

Freimer NB, Sabatti C ( 2005 ) . Guidelines for association studies in Human Molecular Genetics . Human Molecular Genetics vol. 14 , ( 17 ) 2481 - 2483 .

Sandhu MS, Heude B, Young EH, Luben R, Luan J, Khaw K-T, Todd J, Wareham NJ ( 2005 ) . INS VNTR Class Genotype and Indexes of Body Size and Obesity Population-Based Studies of 7,999 Middle-Aged Men and Women . Diabetes vol. 54 , ( 9 ) 2812 - 2815 .

Myint PK, Luben RN, Surtees PG, Wainwright NWJ, Welch AA, Bingham SA, Wareham NJ, Day NE et al. ( 2005 ) . Respiratory function and self-reported functional health: EPIC-Norfolk population study . European Respiratory Journal vol. 26 , ( 3 ) 494 - 502 .

Ishihara LS, Khaw K-T, Luben R, Bingham S, Welch A, Day N, Brayne C ( 2005 ) . Self-reported parkinsonian symptoms in the EPIC-Norfolk cohort . BMC Neurology vol. 5 , ( 1 )

Cebrian A, Lesueur F, Martin S, Leyland J, Ahmed S, Luccarini C, Smith PL, Luben R et al. ( 2005 ) . Polymorphisms in the Initiators of RET (Rearranged during Transfection) Signaling Pathway and Susceptibility to Sporadic Medullary Thyroid Carcinoma . The Journal of Clinical Endocrinology & Metabolism vol. 90 , ( 11 ) 6268 - 6274 .

Benusiglio PR, Lesueur F, Luccarini C, McIntosh J, Luben RN, Smith P, Dunning A, Easton DF et al. ( 2005 ) . Common variation in EMSYand risk of breast and ovarian cancer: a case-control study using HapMap tagging SNPs . BMC Cancer vol. 5 , ( 1 )

Jenab M, Bingham S, Ferrari P, Friesen MD, Al-Delaimy WK, Luben R, Wareham N, Khaw K-T et al. ( 2005 ) . Long-term Cryoconservation and Stability of Vitamin C in Serum Samples of the European Prospective Investigation into Cancer and Nutrition . Cancer Epidemiology Biomarkers & Prevention vol. 14 , ( 7 ) 1837 - 1840 .

( 2005 ) . Epidemiology of Hypertension . Hypertension , Taylor & Francis

Lesueur F, Pharoah PD, Laing S, Ahmed S, Jordan C, Smith PL, Luben R, Wareham NJ et al. ( 2005 ) . Allelic association of the human homologue of the mouse modifier Ptprj with breast cancer . Human Molecular Genetics vol. 14 , ( 16 ) 2349 - 2356 .

Myint PK, Luben RN, Surtees PG, Wainwright NWJ, Welch AA, Bingham SA, Day NE, Wareham NJ et al. ( 2005 ) . Relation Between Self-Reported Physical Functional Health and Chronic Disease Mortality in Men And Women in the European Prospective Investigation Into Cancer (EPIC–Norfolk): A Prospective Population Study . Annals of Epidemiology vol. 16 , ( 6 ) 492 - 500 .

Newhouse SJ, Wallace C, Dobson R, Mein C, Pembroke J, Farrall M, Clayton D, Brown M et al. ( 2005 ) . Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study . Hum Mol Genet vol. 14 , ( 13 ) 1805 - 1814 .

Marcano ACB, Onipinla AK, Caulfield MJ, Munroe PB ( 2005 ) . Recent advances in the identification of genes for human hypertension . Expert Rev Cardiovasc Ther vol. 3 , ( 4 ) 733 - 741 .

Munroe PB, Mitchison HM, Dooley TP, Gardiner RM, Mole SE ( 1995 ) . Analysis of Batten disease candidate genes STP and STM . American Journal of Medical Genetics . vol. 57 , 324 - 326 .

Michels KB, Welch AA, Luben R, Bingham SA, Day NE ( 2005 ) . Measurement of Fruit and Vegetable Consumption with Diet Questionnaires and Implications for Analyses and Interpretation . American Journal of Epidemiology vol. 161 , ( 10 ) 987 - 994 .

Sinha S, Luben RN, Welch A, Bingham S, Wareham NJ, Day NE, Khaw K-T ( 2005 ) . Fibrinogen and cigarette smoking in men and women in the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) population . European Journal of Preventive Cardiology vol. 12 , ( 2 ) 144 - 150 .

Surtees PG, Wainwright NWJ, Luben R, Day NE, Khaw K-T ( 2005 ) . Prospective cohort study of hostility and the risk of cardiovascular disease mortality . International Journal of Cardiology vol. 100 , ( 1 ) 155 - 161 .

Welch AA, Luben R, Khaw KT, Bingham SA ( 2005 ) . The CAFE computer program for nutritional analysis of the EPIC‐Norfolk food frequency questionnaire and identification of extreme nutrient values . Journal of Human Nutrition and Dietetics vol. 18 , ( 2 ) 99 - 116 .

Hu SP, Day NE, Li DR, Luben RN, Cai KL, Ou-Yang T, Li B, Lu XZ et al. ( 2005 ) . Further evidence for an HLA-related recessive mutation in nasopharyngeal carcinoma among the Chinese . British Journal of Cancer vol. 92 , ( 5 ) 967 - 970 .

Boekholdt SM, Keller TT, Wareham NJ, Luben R, Bingham SA, Day NE, Sandhu MS, Jukema JW et al. ( 2005 ) . Serum Levels of Type II Secretory Phospholipase A2 and the Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women . Arteriosclerosis Thrombosis and Vascular Biology vol. 25 , ( 4 ) 839 - 846 .

Low Y-L, Taylor JI, Grace PB, Dowsett M, Scollen S, Dunning AM, Mulligan AA, Welch AA et al. ( 2005 ) . Phytoestrogen Exposure Correlation with Plasma Estradiol in Postmenopausal Women in European Prospective Investigation of Cancer and Nutrition-Norfolk May Involve Diet-Gene Interactions . Cancer Epidemiology Biomarkers & Prevention vol. 14 , ( 1 ) 213 - 220 .

De Castro F, Moron FJ, Montoro L, Galan JJ, Real LM, Ruiz A ( 2005 ) . Re: Polymorphisms Associated With Circulating Sex Hormone Levels in Postmenopausal Women . Journal of the National Cancer Institute vol. 97 , ( 2 ) 152 - 153 .

Mein CA, Caulfield MJ, Munroe PB ( 2005 ) . Selection of candidate genes in hypertension . vol. 108 ,

Pattison DJ, Symmons DPM, Lunt M, Welch A, Luben R, Bingham SA, Khaw K, Day NE et al. ( 2004 ) . Dietary risk factors for the development of inflammatory polyarthritis: Evidence for a role of high level of red meat consumption . Arthritis & Rheumatism vol. 50 , ( 12 ) 3804 - 3812 .

Munroe PB, Dobson R, Pembroke J, Wilson S, Pheby J, Colville-Stewart S, Gilmour K, Macdade M et al. ( 2004 ) . The MRC BRIGHT study: Demographic and biochemical characteristics of the sibling-pair resource . BRITISH JOURNAL OF CLINICAL PHARMACOLOGY . vol. 58 , 688 - 688 .

Khaw K-T, Bingham S, Welch A, Luben R, O'Brien E, Wareham N, Day N ( 2004 ) . Blood pressure and urinary sodium in men and women: the Norfolk Cohort of the European Prospective Investigation into Cancer (EPIC-Norfolk) . American Journal of Clinical Nutrition vol. 80 , ( 5 ) 1397 - 1403 .

Canoy D, Luben R, Welch A, Bingham S, Wareham N, Day N, Khaw K-T ( 2004 ) . Fat distribution, body mass index and blood pressure in 22 090 men and women in the Norfolk cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Norfolk) study . Journal of Hypertension vol. 22 , ( 11 ) 2067 - 2074 .

Lee YW, Oh VMS, Garcia E, Taylor EA, Wu HM, Yap EPH, Kazeem GR, Caulfield MJ et al. ( 2004 ) . Haplotypes of the beta 2-adrenegic receptor gene are associated with essential hypertension in a Singaporean Chinese population . J HYPERTENS vol. 22 , ( 11 ) 2111 - 2116 .

DiCioccio RA, Song H, Waterfall C, Kimura MT, Nagase H, McGuire V, Hogdall E, Shah MN et al. ( 2004 ) . STK15 Polymorphisms and Association with Risk of Invasive Ovarian Cancer . Cancer Epidemiology Biomarkers & Prevention vol. 13 , ( 10 ) 1589 - 1594 .

Freimer N, Sabatti C ( 2004 ) . The use of pedigree, sib-pair and association studies of common diseases for genetic mapping and epidemiology . Nature Genetics vol. 36 , ( 10 ) 1045 - 1051 .

Khaw K-T, Wareham N, Bingham S, Luben R, Welch A, Day N ( 2004 ) . Association of hemoglobin A1c with cardiovascular disease and mortality in adults: the European prospective investigation into cancer in Norfolk . Annals of Internal Medicine vol. 141 , ( 6 ) 413 - 420 .

Boekholdt SM, Peters RJG, Day NE, Luben R, Bingham SA, Wareham NJ, Hack CE, Reitsma PH et al. ( 2004 ) . Macrophage migration inhibitory factor and the risk of myocardial infarction or death due to coronary artery disease in adults without prior myocardial infarction or stroke: The EPIC-Norfolk Prospective Population study . The American Journal of Medicine vol. 117 , ( 6 ) 390 - 397 .

Burman J, Tran CH, Glatt C, Freimer NB, Edwards RH ( 2004 ) . The effect of rare human sequence variants on the function of vesicular monoamine transporter 2 . Pharmacogenetics and Genomics vol. 14 , ( 9 ) 587 - 594 .

Boekholdt SM, Kuivenhoven J-A, Wareham NJ, Peters RJG, Jukema JW, Luben R, Bingham SA, Day NE et al. ( 2004 ) . Plasma Levels of Cholesteryl Ester Transfer Protein and the Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women . Circulation vol. 110 , ( 11 ) 1418 - 1423 .

Jakes RW, Day NE, Luben R, Welch A, Bingham S, Mitchell J, Hennings S, Rennie K et al. ( 2004 ) . Adjusting for energy intake—what measure to use in nutritional epidemiological studies? . International Journal of Epidemiology vol. 33 , ( 6 ) 1382 - 1386 .

Day NE, Wong MY, Bingham S, Khaw KT, Luben R, Michels KB, Welch A, Wareham NJ ( 2004 ) . Correlated measurement error—implications for nutritional epidemiology . International Journal of Epidemiology vol. 33 , ( 6 ) 1373 - 1381 .

Mehan MR, Freimer NB, Ophoff RA ( 2004 ) . A genome-wide survey of segmental duplications that mediate common human genetic variation of chromosomal architecture . Human Genomics vol. 1 , ( 5 )

Patel BD, Luben RN, Welch AA, Bingham SA, Khaw K-T, Day NE, Lomas DA, Wareham NJ ( 2004 ) . Childhood smoking is an independent risk factor for obstructive airways disease in women . Thorax vol. 59 , ( 8 )

Mathews CA, Waller J, Glidden D, Lowe TL, Herrera LD, Budman CL, Erenberg G, Naarden A et al. ( 2004 ) . Self injurious behaviour in Tourette syndrome: correlates with impulsivity and impulse control . Journal of Neurology Neurosurgery & Psychiatry vol. 75 , ( 8 )

Shohaimi S, Welch A, Bingham S, Luben R, Day N, Wareham N, Khaw K-T ( 2004 ) . Residential area deprivation predicts fruit and vegetable consumption independently of individual educational level and occupational social class: a cross sectional population study in the Norfolk cohort of the European Prospective Investigation into Cancer (EPIC-Norfolk) . Journal of Epidemiology & Community Health vol. 58 , ( 8 )

Miettunen J, Kantojärvi L, Ekelund J, Veijola J, Karvonen JT, Peltonen L, Järvelin MR, Freimer N et al. ( 2004 ) . A large population cohort provides normative data for investigation of temperament . Acta Psychiatrica Scandinavica vol. 110 , ( 2 ) 150 - 157 .

Shohaimi S, Welch A, Bingham S, Luben R, Day N, Wareham N, Khaw K ( 2004 ) . Area deprivation predicts lung function independently of education and social class . European Respiratory Journal vol. 24 , ( 1 ) 157 - 161 .

Michels KB, Bingham SA, Luben R, Welch AA, Day NE ( 2004 ) . The Effect of Correlated Measurement Error in Multivariate Models of Diet . American Journal of Epidemiology vol. 160 , ( 1 ) 59 - 67 .

Klomp LWJ, Vargas JC, van Mil SWC, Pawlikowska L, Strautnieks SS, van Eijk MJT, Juijn JA, Pabón‐Peña C et al. ( 2004 ) . Characterization of mutations in ATP8B1 associated with hereditary cholestasis . Hepatology vol. 40 , ( 1 ) 27 - 38 .

Dunning AM, Dowsett M, Healey CS, Tee L, Luben RN, Folkerd E, Novik KL, Kelemen L et al. ( 2004 ) . Polymorphisms Associated With Circulating Sex Hormone Levels in Postmenopausal Women . Journal of the National Cancer Institute vol. 96 , ( 12 ) 936 - 945 .

Macleod J, Smith GD, Lynch J ( 2004 ) . RE: “SENSE OF COHERENCE AND MORTALITY IN MEN AND WOMEN IN THE EPIC-NORFOLK UNITED KINGDOM PROSPECTIVE COHORT STUDY” . American Journal of Epidemiology vol. 159 , ( 12 ) 1202 - 1203 .

Tjønneland AM, Overvad K, Bingham SA, Day NE, Luben R, Ferrari P, Slimani N, Norat T et al. ( 2004 ) . Dietary fibers in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study . Ugeskrift for Laeger vol. 166 , ( 25 ) 2458 - 2460 .

Pattison DJ, Silman AJ, Goodson NJ, Lunt M, Bunn D, Luben R, Welch A, Bingham S et al. ( 2004 ) . Vitamin C and the risk of developing inflammatory polyarthritis: prospective nested case-control study . Annals of the Rheumatic Diseases vol. 63 , ( 7 )

Canoy D, Luben R, Welch A, Bingham S, Wareham N, Day N, Khaw KT ( 2004 ) . Abdominal Obesity and Respiratory Function in Men and Women in the EPIC-Norfolk Study, United Kingdom . American Journal of Epidemiology vol. 159 , ( 12 ) 1140 - 1149 .

Khaw K-T, Wareham N, Bingham S, Luben R, Welch A, Day N ( 2004 ) . Preliminary Communication: Glycated Hemoglobin, Diabetes, and Incident Colorectal Cancer in Men and Women: A Prospective Analysis from the European Prospective Investigation into Cancer–Norfolk Study . Cancer Epidemiology Biomarkers & Prevention vol. 13 , ( 6 ) 915 - 919 .

Boekholdt SM, Peters RJG, Hack CE, Day NE, Luben R, Bingham SA, Wareham NJ, Reitsma PH et al. ( 2004 ) . IL-8 Plasma Concentrations and the Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women . Arteriosclerosis Thrombosis and Vascular Biology vol. 24 , ( 8 ) 1503 - 1508 .

Newhouse S, Dobson R, Wallace C, Pembroke J, Garcia E, Mein C, Clayton D, Samani N et al. ( 2004 ) . No association of the WNK1 gene with essential hypertension in the MRC BRIGHT study . JOURNAL OF HYPERTENSION . vol. 22 , S212 - S212 .

Bearden CE, Reus VI, Freimer NB ( 2004 ) . Why genetic investigation of psychiatric disorders is so difficult . Current Opinion in Genetics & Development vol. 14 , ( 3 ) 280 - 286 .

Grace PB, Taylor JI, Low Y-L, Luben RN, Mulligan AA, Botting NP, Dowsett M, Welch AA et al. ( 2004 ) . Phytoestrogen Concentrations in Serum and Spot Urine as Biomarkers for Dietary Phytoestrogen Intake and Their Relation to Breast Cancer Risk in European Prospective Investigation of Cancer and Nutrition-Norfolk . Cancer Epidemiology Biomarkers & Prevention vol. 13 , ( 5 ) 698 - 708 .

Rahman P, Jones A, Curtis J, Bartlett S, Peddle L, Fernandez BA, Freimer NB ( 2004 ) . The Newfoundland population: a unique resource for genetic investigation of complex diseases . Human Molecular Genetics vol. 13 , ( 12 ) 1287 - 1287 .

Mein CA, Caulfield MJ, Dobson RJ, Munroe PB ( 2004 ) . Genetics of essential hypertension . Human Molecular Genetics vol. 13 , ( REV. ISS. 1 )

Mein CA, Caulfield MJ, Dobson RJ, Munroe PB ( 2004 ) . Genetics of essential hypertension . Hum Mol Genet vol. 13 Spec No 1 , R169 - R175 .

Shohaimi S, Bingham S, Welch A, Luben R, Day N, Wareham N, Khaw K-T ( 2004 ) . Occupational social class, educational level and area deprivation independently predict plasma ascorbic acid concentration: a cross-sectional population based study in the Norfolk cohort of the European Prospective Investigation into Cancer (EPIC-Norfolk) . European Journal of Clinical Nutrition vol. 58 , ( 10 ) 1432 - 1435 .

Goodson NJ, Silman AJ, Pattison DJ, Lunt M, Bunn D, Luben R, Day N, Khaw K-T et al. ( 2004 ) . Traditional cardiovascular risk factors measured prior to the onset of inflammatory polyarthritis . Rheumatology vol. 43 , ( 6 ) 731 - 736 .

Mathews CA, Reus VI, Bejarano J, Escamilla MA, Fournier E, Herrera LD, Lowe TL, McInnes LA et al. ( 2004 ) . Genetic studies of neuropsychiatric disorders in Costa Rica: a model for the use of isolated populations . Psychiatric Genetics vol. 14 , ( 1 ) 13 - 23 .

Pawlikowska L, Groen A, Eppens EF, Kunne C, Ottenhoff R, Looije N, Knisely AS, Killeen NP et al. ( 2004 ) . A mouse genetic model for familial cholestasis caused by ATP8B1 mutations reveals perturbed bile salt homeostasis but no impairment in bile secretion . Human Molecular Genetics vol. 13 , ( 8 ) 881 - 892 .

Yuyun MF, Khaw K-T, Luben R, Welch A, Bingham S, Day NE, Wareham NJ ( 2004 ) . A Prospective Study of Microalbuminuria and Incident Coronary Heart Disease and Its Prognostic Significance in a British Population . American Journal of Epidemiology vol. 159 , ( 3 ) 284 - 293 .

Yuyun MF, Khaw K-T, Luben R, Welch A, Bingham S, Day NE, Wareham NJ ( 2004 ) . Microalbuminuria independently predicts all-cause and cardiovascular mortality in a British population: The European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) population study . International Journal of Epidemiology vol. 33 , ( 1 ) 189 - 198 .

Harding A-H, Day NE, Khaw K-T, Bingham SA, Luben RN, Welsh A, Wareham NJ ( 2004 ) . Habitual fish consumption and glycated haemoglobin: The EPIC-Norfolk Study . European Journal of Clinical Nutrition vol. 58 , ( 2 ) 277 - 284 .

Yuyun MF, Khaw K, Luben R, Welch A, Bingham S, Day NE, Wareham NJ ( 2004 ) . Microalbuminuria and stroke in a British population: the European Prospective Investigation into Cancer in Norfolk (EPIC‐Norfolk) population study . Journal of Internal Medicine vol. 255 , ( 2 ) 247 - 256 .

Harding A-H, Day NE, Khaw K-T, Bingham S, Luben R, Welsh A, Wareham NJ ( 2004 ) . Dietary Fat and the Risk of Clinical Type 2 Diabetes . American Journal of Epidemiology vol. 159 , ( 1 ) 73 - 82 .

Khaw K-T, Reeve J, Luben R, Bingham S, Welch A, Wareham N, Oakes S, Day N ( 2004 ) . Prediction of total and hip fracture risk in men and women by quantitative ultrasound of the calcaneus: EPIC-Norfolk prospective population study . The Lancet vol. 363 , ( 9404 ) 197 - 202 .

Wolkoff AW, Suchy FJ, Moseley RH, Meier PJ, Gollan JL, Freimer N, Fitz JG, Boyer JL et al. ( 1998 ) . Advances in hepatic transport: Molecular mechanisms, genetic disorders, and treatment. A summary of the 1998 AASLD single topic conference . Hepatology . vol. 28 , 1713 - 1719 .

Bull LN, Carlton VE, Stricker NL, Baharloo S, DeYoung JA, Freimer NB, Magid MS, Kahn E et al. ( 2003 ) . Genetic and morphological findings in progressive familial intrahepatic cholestasis (Byler disease [PFIC‐1] and Byler syndrome): Evidence for heterogeneity . Hepatology vol. 26 , ( 1 ) 155 - 164 .

Knisely AS, Freimer NB ( 2003 ) . Insight into bile duct differentiation takes (notched) wings . Hepatology vol. 27 , ( 1 ) 298 - 298 .

Surtees P, Wainwright N, Luben R, Khaw K-T, Day N ( 2003 ) . Sense of Coherence and Mortality in Men and Women in the EPIC-Norfolk United Kingdom Prospective Cohort Study . American Journal of Epidemiology vol. 158 , ( 12 ) 1202 - 1209 .

Surtees P, Wainwright N, Khaw K-T, Luben R, Brayne C, Day N ( 2003 ) . Inflammatory dispositions: a population-based study of the association between hostility and peripheral leukocyte counts . Personality and Individual Differences vol. 35 , ( 6 ) 1271 - 1284 .

Glatt CE, Tampilic M, Christie C, DeYoung J, Freimer NB ( 2003 ) . Re‐Screening serotonin receptors for genetic variants identifies population and molecular genetic complexity . American Journal of Medical Genetics Part B Neuropsychiatric Genetics vol. 124B , ( 1 ) 92 - 100 .

Surtees P, Wainwright N, Day N, Brayne C, Luben R, Khaw K-T ( 2003 ) . Adverse experience in childhood as a developmental risk factor for altered immune status in adulthood . International Journal of Behavioral Medicine vol. 10 , ( 3 ) 251 - 268 .

( 2003 ) . DEPARTMENT OF ERROR . The Lancet vol. 362 , ( 9388 )

Caulfield M, Munroe P, Pembroke J, Study. FTMBGOH ( 2003 ) . Genome-wide mapping of human loci for essential hypertension . ACC Current Journal Review vol. 12 , ( 5 ) 32 - 33 .

Jakes RW, Day NE, Khaw K-T, Luben R, Oakes S, Welch A, Bingham S, Wareham NJ ( 2003 ) . Television viewing and low participation in vigorous recreation are independently associated with obesity and markers of cardiovascular disease risk: EPIC-Norfolk population-based study . European Journal of Clinical Nutrition vol. 57 , ( 9 ) 1089 - 1096 .

Hong KS, McInnes LA, Service SK, Song T, Lucas J, Silva S, Fournier E, León P et al. ( 2003 ) . Genetic mapping using haplotype and model‐free linkage analysis supports previous evidence for a locus predisposing to severe bipolar disorder at 5q31‐33 . American Journal of Medical Genetics Part B Neuropsychiatric Genetics vol. 125B , ( 1 ) 83 - 86 .

Rahman P, Jones A, Curtis J, Bartlett S, Peddle L, Fernandez BA, Freimer NB ( 2003 ) . The Newfoundland population: a unique resource for genetic investigation of complex diseases† . Human Molecular Genetics vol. 12 , ( suppl_2 ) r167 - r172 .

Newhouse SJ, Garcia E, Caulfield M, Munroe P ( 2003 ) . Haplotype structure of the WNK1 gene and association studies in hypertensive populations . BRITISH JOURNAL OF CLINICAL PHARMACOLOGY . vol. 56 , 245 - 245 .

Smith MR, Kinmonth A-L, Luben RN, Bingham S, Day NE, Wareham NJ, Welch A, Khaw K-T ( 2003 ) . Smoking status and differential white cell count in men and women in the EPIC-Norfolk population . Atherosclerosis vol. 169 , ( 2 ) 331 - 337 .

Bingham SA, Luben R, Welch A, Wareham N, Khaw K-T, Day N ( 2003 ) . Are imprecise methods obscuring a relation between fat and breast cancer? . The Lancet vol. 362 , ( 9379 ) 212 - 214 .

Munroe PB, Editorial Board ( 2003 ) . Hypercholesterolaemia and vascular function: is the p22phox gene the missing link? . Clin Sci (Lond) vol. 105 , ( 1 ) 11 - 12 .

Caulfield M, Munroe P, Pembroke J, Samani N, Dominiczak A, Brown M, Benjamin N, Webster J et al. ( 2003 ) . Genome-wide mapping of human loci for essential hypertension . Lancet vol. 361 , ( 9375 ) 2118 - 2123 .

Segurado R, Detera-Wadleigh SD, Levinson DF, Lewis CM, Gill M, Nurnberger JI, Craddock N, DePaulo JR et al. ( 2003 ) . Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part III: Bipolar Disorder . American Journal of Human Genetics vol. 73 , ( 1 ) 49 - 62 .

Sabatti C, Service S, Freimer N ( 2003 ) . False Discovery Rate in Linkage and Association Genome Screens for Complex Disorders . Genetics vol. 164 , ( 2 ) 829 - 833 .

Dunning AM, Ellis PD, McBride S, Kirschenlohr HL, Healey CS, Kemp PR, Luben RN, Chang-Claude J et al. ( 2003 ) . A transforming growth factorbeta1 signal peptide variant increases secretion in vitro and is associated with increased incidence of invasive breast cancer . Cancer Research vol. 63 , ( 10 ) 2610 - 2615 .

Bingham SA, Day NE, Luben R, Ferrari P, Slimani N, Norat T, Clavel-Chapelon F, Kesse E et al. ( 2003 ) . Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study . The Lancet vol. 361 , ( 9368 ) 1496 - 1501 .

Freimer N, Sabatti C ( 2003 ) . The Human Phenome Project . Nature Genetics vol. 34 , ( 1 ) 15 - 21 .

Service SK, Sandkuijl LA, Freimer NB ( 2003 ) . Cost-Effective Designs for Linkage Disequilibrium Mapping of Complex Traits . American Journal of Human Genetics vol. 72 , ( 5 ) 1213 - 1220 .

Surtees P, Wainwright N, Day N, Luben R, Brayne C, Khaw K-T ( 2003 ) . Association of depression with peripheral leukocyte counts in EPIC-Norfolk—role of sex and cigarette smoking . Journal of Psychosomatic Research vol. 54 , ( 4 ) 303 - 306 .

Shohaimi S, Luben R, Wareham N, Day N, Bingham S, Welch A, Oakes S, Khaw K-T ( 2003 ) . Residential area deprivation predicts smoking habit independently of individual educational level and occupational social class. A cross sectional study in the Norfolk cohort of the European Investigation into Cancer (EPIC-Norfolk) . Journal of Epidemiology & Community Health vol. 57 , ( 4 )

Knight J, Munroe PB, Pembroke JC, Caulfield MJ ( 2003 ) . Human chromosome 17 in essential hypertension . Ann Hum Genet vol. 67 , ( Pt 2 ) 193 - 206 .

Carvajal-Carmona LG, Ophoff R, Service S, Hartiala J, Molina J, Leon P, Ospina J, Bedoya G et al. ( 2003 ) . Genetic demography of Antioquia (Colombia) and the Central Valley of Costa Rica . Human Genetics vol. 112 , ( 5-6 ) 534 - 541 .

Garcia EA, Newhouse S, Caulfield MJ, Munroe PB ( 2003 ) . Genes and hypertension . Curr Pharm Des vol. 9 , ( 21 ) 1679 - 1689 .

Garcia EA, Aristizabal D, McEwen J, Mendez J, Munroe P, Caulfield M ( 2002 ) . Guanine nucleotide binding 3 (GNB3) haplotype analysis in the Venecia-Colombia Latin-American blood pressure study . AMERICAN JOURNAL OF HUMAN GENETICS . vol. 71 , 366 - 366 .

Harding A-H, Sargeant L, Khaw K-T, Welch A, Oakes S, Luben R, Bingham S, Day N et al. ( 2002 ) . Cross-sectional association between total level and type of alcohol consumption and glycosylated haemoglobin level: the EPIC-Norfolk Study . European Journal of Clinical Nutrition vol. 56 , ( 9 ) 882 - 890 .

Escamilla MA, Batki S, Reus VI, Spesny M, Molina J, Service S, Vinogradov S, Neylan T et al. ( 2002 ) . Comorbidity of bipolar disorder and substance abuse in Costa Rica: pedigree- and population-based studies . Journal of Affective Disorders vol. 71 , ( 1-3 ) 71 - 83 .

Merikangas KR, Chakravarti A, Moldin SO, Araj H, Blangero J, Burmeister M, Crabbe JC, Depaulo JR et al. ( 2002 ) . Future of genetics of mood disorders research . Biological Psychiatry vol. 52 , ( 6 ) 457 - 477 .

Sandhu MS, Luben R, Day NE, Khaw K-T ( 2002 ) . Self-reported birth weight and subsequent risk of colorectal cancer . Cancer Epidemiology Biomarkers & Prevention vol. 11 , ( 9 ) 935 - 938 .

Ophoff RA, Escamilla MA, Service SK, Spesny M, Meshi DB, Poon W, Molina J, Fournier E et al. ( 2002 ) . Genomewide Linkage Disequilibrium Mapping of Severe Bipolar Disorder in a Population Isolate . American Journal of Human Genetics vol. 71 , ( 3 ) 565 - 574 .

Jakes RW, Day NE, Patel B, Khaw K-T, Oakes S, Luben R, Welch A, Bingham S et al. ( 2002 ) . Physical Inactivity Is Associated with Lower Forced Expiratory Volume in 1 Second . American Journal of Epidemiology vol. 156 , ( 2 ) 139 - 147 .

Glatt CE, Freimer NB ( 2002 ) . Association analysis of candidate genes for neuropsychiatric disease: the perpetual campaign . Trends in Genetics vol. 18 , ( 6 ) 307 - 312 .

Caulfield M, Pembroke J, Dominiczak A, Samani N, Brown M, Clayton D, Ratcliffe P, Lathrop M et al. ( 2002 ) . The MRC British Genetics of Hypertension Study - Genome-wide screen results . JOURNAL OF HYPERTENSION . vol. 20 , S7 - S7 .

Mulligan AA, Luben RN, Welch AA, Bingham SA ( 2002 ) . Daidzein and genistein intakes in England (the EPIC Norfolk cohort) . IARC Scientific Publications vol. 156 , 369 - 370 .

Bingham SA, Luben R, Day NE, Riboli E ( 2002 ) . Plant polysaccharides, meat and colorectal cancer . IARC Scientific Publications vol. 156 , 349 - 352 .

Luben R, Khaw KT, Welch A, Bingham S, Wareham N, Oakes S, Day NE ( 2002 ) . Plasma vitamin C, cancer mortality and incidence in men and women: a prospective study . IARC Scientific Publications vol. 156 , 117 - 118 .

Titan SMO, Bingham S, Welch A, Luben R, Oakes S, Day N, Khaw K-T ( 2001 ) . Frequency of eating and concentrations of serum cholesterol in the Norfolk population of the European prospective investigation into cancer (EPIC-Norfolk): cross sectional study . The BMJ vol. 323 , ( 7324 )

Harding A-H, Sargeant LA, Welch A, Oakes S, Luben RN, Bingham S, Day NE, Khaw K-T et al. ( 2001 ) . Fat Consumption and HbA1c Levels The EPIC-Norfolk Study . Diabetes Care vol. 24 , ( 11 ) 1911 - 1916 .

Basham VM, Pharoah PD, Healey CS, Luben RN, Day NE, Easton DF, Ponder BA, Dunning AM ( 2001 ) . Polymorphisms in CYP1A1 and smoking: no association with breast cancer risk . Carcinogenesis vol. 22 , ( 11 ) 1797 - 1800 .

Sandhu MS, Luben R, Khaw KT ( 2001 ) . Self reported non-insulin dependent diabetes, family history, and risk of prevalent colorectal cancer: population based, cross sectional study . Journal of Epidemiology & Community Health vol. 55 , ( 11 )

McInnes LA, Service SK, Reus VI, Barnes G, Charlat O, Jawahar S, Lewitzky S, Yang Q et al. ( 2001 ) . Fine-scale mapping of a locus for severe bipolar mood disorder on chromosome 18p11.3 in the Costa Rican population . Proceedings of the National Academy of Sciences of the United States of America vol. 98 , ( 20 ) 11485 - 11490 .

Metherell LA, Akker SA, Munroe PB, Rose SJ, Caulfield M, Savage MO, Chew SL, Clark AJ ( 2001 ) . Pseudoexon activation as a novel mechanism for disease resulting in atypical growth-hormone insensitivity . Am J Hum Genet vol. 69 , ( 3 ) 641 - 646 .

Faham M, Baharloo S, Tomitaka S, DeYoung J, Freimer NB ( 2001 ) . Mismatch repair detection (MRD): high-throughput scanning for DNA variations . Human Molecular Genetics vol. 10 , ( 16 ) 1657 - 1664 .

McKeown NM, Day NE, Welch AA, Runswick SA, Luben RN, Mulligan AA, McTaggart A, Bingham SA ( 2001 ) . Use of biological markers to validate self-reported dietary intake in a random sample of the European Prospective Investigation into Cancer United Kingdom Norfolk cohort 1 , 2 , 3 . American Journal of Clinical Nutrition vol. 74 , ( 2 ) 188 - 196 .

Ophoff RA, DeYoung J, Service SK, Joosse M, Caffo NA, Sandkuijl LA, Terwindt GM, Haan J et al. ( 2001 ) . Hereditary Vascular Retinopathy, Cerebroretinal Vasculopathy, and Hereditary Endotheliopathy with Retinopathy, Nephropathy, and Stroke Map to a Single Locus on Chromosome 3p21.1-p21.3 . American Journal of Human Genetics vol. 69 , ( 2 ) 447 - 453 .

Sargeant L, Khaw K, Bingham S, Day N, Luben R, Oakes S, Welch A, Wareham N ( 2001 ) . Fruit and vegetable intake and population glycosylated haemoglobin levels: the EPIC-Norfolk Study . European Journal of Clinical Nutrition vol. 55 , ( 5 ) 342 - 348 .

Sargeant LA, Khaw KT, Bingham S, Day NE, Luben RN, Oakes S, Welch A, Wareham NJ ( 2001 ) . Cigarette smoking and glycaemia: the EPIC-Norfolk Study . International Journal of Epidemiology vol. 30 , ( 3 ) 547 - 554 .

Sala E, Warren R, McCann J, Duffy S, Luben R, Day N ( 2001 ) . Mammographic parenchymal patterns and breast cancer natural history--a case-control study . Acta Oncologica vol. 40 , ( 4 ) 461 - 465 .

Sandhu MS, Luben R, Khaw K-T ( 2001 ) . Prevalence and family history of colorectal cancer: implications for screening . Journal of Medical Screening vol. 8 , ( 2 ) 69 - 72 .

Leung KY, Greene ND, Munroe PB, Mole SE ( 2001 ) . Identification of a transactivation motif in the CLN3 protein . IUBMB Life vol. 51 , ( 5 ) 295 - 298 .

MATHEWS CA, AMIGHETTI LDH, LOWE TL, VAN DE WETERING BJM, FREIMER NB, REUS VI ( 2001 ) . Cultural Influences on Diagnosis and Perception of Tourette Syndrome in Costa Rica . Journal of the American Academy of Child & Adolescent Psychiatry vol. 40 , ( 4 ) 456 - 463 .

Glatt CE, DeYoung JA, Delgado S, Service SK, Giacomini KM, Edwards RH, Risch N, Freimer NB ( 2001 ) . Screening a large reference sample to identify very low frequency sequence variants: comparisons between two genes . Nature Genetics vol. 27 , ( 4 ) 435 - 438 .

Couto E, Harrison D, Duffy S, Myles J, Sala E, Warren R, Day N, Luben R et al. ( 2001 ) . Estimation of disease progression parameters from case-control data: application to mammographic patterns and breast cancer natural history . Journal of Cancer Epidemiology and Prevention vol. 6 , ( 2 ) 235 - 242 .

Khaw K-T, Bingham S, Welch A, Luben R, Wareham N, Oakes S, Day N ( 2001 ) . Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study . The Lancet vol. 357 , ( 9257 ) 657 - 663 .

Service SK, Ophoff RA, Freimer NB ( 2001 ) . The genome-wide distribution of background linkage disequilibrium in a population isolate . Human Molecular Genetics vol. 10 , ( 5 ) 545 - 551 .

Garner C, McInnes LA, Service SK, Spesny M, Fournier E, Leon P, Freimer NB ( 2001 ) . Linkage Analysis of a Complex Pedigree with Severe Bipolar Disorder, Using a Markov Chain Monte Carlo Method . American Journal of Human Genetics vol. 68 , ( 4 ) 1061 - 1064 .

Jakes RW, Khaw K-T, Day NE, Bingham S, Welch A, Oakes S, Luben R, Dalzell N et al. ( 2001 ) . Patterns of physical activity and ultrasound attenuation by heel bone among Norfolk cohort of European Prospective Investigation of Cancer (EPIC Norfolk): population based study . The BMJ vol. 322 , ( 7279 )

Khaw K-T, Wareham N, Luben R, Bingham S, Oakes S, Welch A, Day N ( 2001 ) . Glycated haemoglobin, diabetes, and mortality in men in Norfolk cohort of European Prospective Investigation of Cancer and Nutrition (EPIC-Norfolk) . The BMJ vol. 322 , ( 7277 )

Leung KY, Greene ND, Munroe PB, Mole SE ( 2001 ) . Analysis of CLN3-protein interactions using the yeast two-hybrid system . Eur J Paediatr Neurol vol. 5 Suppl A , 89 - 93 .

Escamilla MA, McInnes LA, Service SK, Spesny M, Reus VI, Molina J, Gallegos A, Fournier E et al. ( 2001 ) . Genome screening for linkage disequilibrium in a Costa Rican sample of patients with bipolar‐I disorder: A follow‐up study on chromosome 18 . American Journal of Medical Genetics vol. 105 , ( 2 ) 207 - 213 .

Alsanea O, Wada N, Ain K, Wong M, Taylor K, Ituarte PHG, Treseler PA, Weier H-U et al. ( 2000 ) . Is familial non-medullary thyroid carcinoma more aggressive than sporadic thyroid cancer? A multicenter series . Surgery vol. 128 , ( 6 ) 1043 - 1051 .

Dunning AM, Durocher F, Healey CS, Teare MD, McBride SE, Carlomagno F, Xu C-F, Dawson E et al. ( 2000 ) . The Extent of Linkage Disequilibrium in Four Populations with Distinct Demographic Histories . American Journal of Human Genetics vol. 67 , ( 6 ) 1544 - 1554 .

Healey CS, Dunning AM, Dawn Teare M, Chase D, Parker L, Burn J, Chang-Claude J, Mannermaa A et al. ( 2000 ) . A common variant in BRCA2 is associated with both breast cancer risk and prenatal viability . Nature Genetics vol. 26 , ( 3 ) 362 - 364 .

Ospina-Duque J, Duque C, Carvajal-Carmona L, Ortiz-Barrientos D, Soto I, Pineda N, Cuartas M, Calle J et al. ( 2000 ) . An association study of bipolar mood disorder (type I) with the 5-HTTLPR serotonin transporter polymorphism in a human population isolate from Colombia . Neuroscience Letters vol. 292 , ( 3 ) 199 - 202 .

Bull LN, Roche E, Song EJ, Pedersen J, Knisely AS, van der Hagen CB, Eiklid K, Aagenaes Ø et al. ( 2000 ) . Mapping of the Locus for Cholestasis-Lymphedema Syndrome (Aagenaes Syndrome) to a 6.6-cM Interval on Chromosome 15q . American Journal of Human Genetics vol. 67 , ( 4 ) 994 - 999 .

Ospina-Duque J, Carvajal-Carmona L, Calle J, López C, Ochoa L, García J, Cuartas M, Ortiz-Barrientos D et al. ( 2000 ) . A search for genetic loci involved in predisposition to bipolar mood disorder in the population of Antioquia, Colombia . American Journal of Medical Genetics - Neuropsychiatric Genetics vol. 96 , ( 4 )

Ospina-Duque J, Duque C, Carvajal-Carmona L, Cuartas M, Ortiz-Barrientos D, Soto I, Pineda N, Calle J et al. ( 2000 ) . Lack of association between a serotonin transporter promoter polymorphism and BP1 in Antioquia, Colombia . American Journal of Medical Genetics - Neuropsychiatric Genetics vol. 96 , ( 4 ) 490 - 491 .

Sala E, Warren R, McCann J, Duffy S, Luben R, Day N ( 2000 ) . High-risk mammographic parenchymal patterns, hormone replacement therapy and other risk factors: a case-control study . International Journal of Epidemiology vol. 29 , ( 4 ) 629 - 636 .

Baharloo S, Service SK, Risch N, Gitschier J, Freimer NB ( 2000 ) . Familial Aggregation of Absolute Pitch . American Journal of Human Genetics vol. 67 , ( 3 ) 755 - 758 .

Sala E, Warren R, Duffy S, Welch A, Luben R, Day N ( 2000 ) . High risk mammographic parenchymal patterns and diet: a case–control study . British Journal of Cancer vol. 83 , ( 1 ) 121 - 126 .

Munroe PB, Caulfield MJ ( 2000 ) . Genetics of hypertension . Current Opinion in Genetics & Development vol. 10 , ( 3 ) 325 - 329 .

Sargeant LA, Wareham NJ, Bingham S, Day NE, Luben RN, Oakes S, Welch A, Khaw KT ( 2000 ) . Vitamin C and hyperglycemia in the European Prospective Investigation into Cancer--Norfolk (EPIC-Norfolk) study: a population-based study . Diabetes Care vol. 23 , ( 6 ) 726 - 732 .

Munroe PB, Knight J, Caulfield MJ ( 2000 ) . 1990-2000: progress in determining high blood pressure genes . Annals, Academy of Medicine, Singapore vol. 29 , ( 3 ) 357 - 363 .

Escamilla MA, DeMille MC, Benavides E, Roche E, Almasy L, Pittman S, Hauser J, Lew DF et al. ( 2000 ) . A Minimalist Approach to Gene Mapping: Locating the Gene for Acheiropodia, by Homozygosity Analysis . American Journal of Human Genetics vol. 66 , ( 6 ) 1995 - 2000 .

Healey CS, Dunning AM, Durocher F, Teare D, Pharoah PDP, Luben RN, Easton DF, Ponder BAJ ( 2000 ) . Polymorphisms in the human aromatase cytochrome P450 gene (CYP19) and breast cancer risk . Carcinogenesis vol. 21 , ( 2 ) 189 - 193 .

Sala E, Warren R, McCann J, Duffy S, Luben R, Day N ( 2000 ) . Smoking and high-risk mammographic parenchymal patterns: a case-control study . Breast Cancer Research vol. 2 , ( 1 )

Caulfield M, Papp J, Pembroke J, Munroe P, Farrall M, Dominiczak A, Clayton D, Ratcliffe P et al. ( 2000 ) . A new tool for checks of data precision within the MRC British genetics of hypertension study . J HYPERTENS . vol. 18 , S180 - S180 .

Munroe P, Sandhu M, Jadhav D, Knight J, Clark A, Caulfield M ( 2000 ) . No association of the epithelial sodium channel beta-subunit T594M variant with essential hypertension in an African Caribbean population . J HYPERTENS vol. 18 , S178 - S178 .

Sala E, Solomon L, Warren R, McCann J, Duffy S, Luben R, Day N ( 2000 ) . Size, node status and grade of breast tumours: association with mammographic parenchymal patterns . European Radiology vol. 10 , ( 1 ) 157 - 161 .

Fraser GE, Welch A, Luben R, Bingham SA, Day NE ( 2000 ) . The Effect of Age, Sex, and Education on Food Consumption of a Middle-Aged English Cohort—EPIC in East Anglia . Preventive Medicine vol. 30 , ( 1 ) 26 - 34 .

Janes RW, Munroe PB, Mitchison HM, Gardiner RM, Mole SE, Wallace BA ( 1999 ) . A model for Batten disease protein CLN3: Functional implications from homology and mutations . FEBS Letters vol. 399 , ( 1-2 ) 75 - 77 .

Sala E, Warren R, McCann J, Duffy S, Luben R, Day N ( 1999 ) . High-risk mammographic parenchymal patterns and anthropometric measures: A case–control study . British Journal of Cancer vol. 81 , ( 7 ) 1257 - 1261 .

Dunning AM, McBride S, Gregory J, Durocher F, Foster NA, Healey CS, Smith N, Pharoah PDP et al. ( 1999 ) . No association between androgen or vitamin D receptor gene polymorphisms and risk of breast cancer . Carcinogenesis vol. 20 , ( 11 ) 2131 - 2135 .

Mole SE, Mitchison HM, Munroe PB ( 1999 ) . Molecular basis of the neuronal ceroid lipofuscinoses: Mutations in CLN1, CLN2, CLN3, and CLN5 . Human Mutation vol. 14 , ( 3 ) 199 - 215 .

Bull LN, Pabón-Peña CR, Freimer NB ( 1999 ) . Compound Microsatellite Repeats: Practical and Theoretical Features . Genome Research vol. 9 , ( 9 ) 830 - 838 .

Day N, Oakes S, Luben R, Khaw KT, Bingham S, Welch A, Wareham N ( 1999 ) . EPIC-Norfolk: study design and characteristics of the cohort. European Prospective Investigation of Cancer . British Journal of Cancer . vol. 80 Suppl 1 , 95 - 103 .

Not Available NA ( 1999 ) . Erratum: Hum Genet (1999) 104 : 241–248 . Human Genetics vol. 104 , ( 6 ) 528 - 528 .

Escamilla MA, McInnes LA, Spesny M, Reus VI, Service SK, Shimayoshi N, Tyler DJ, Silva S et al. ( 1999 ) . Assessing the Feasibility of Linkage Disequilibrium Methods for Mapping Complex Traits: An Initial Screen for Bipolar Disorder Loci on Chromosome 18 . American Journal of Human Genetics vol. 64 , ( 6 ) 1670 - 1678 .

Service SK, Lang DWT, Freimer NB, Sandkuijl LA ( 1999 ) . Linkage-Disequilibrium Mapping of Disease Genes by Reconstruction of Ancestral Haplotypes in Founder Populations . American Journal of Human Genetics vol. 64 , ( 6 ) 1728 - 1738 .

Bull LN, Juijn JA, Liao M, van Eijk MJT, Sinke RJ, Stricker NL, DeYoung JA, Carlton VEH et al. ( 1999 ) . Fine-resolution mapping by haplotype evaluation: the examples of PFIC1 and BRIC . Human Genetics vol. 104 , ( 3 ) 241 - 248 .

Stephenson JBP, Greene NDE, Leung KY, Munroe PB, Mole SE, Gardiner RM, Taschner PEM, O'Regan M et al. ( 1999 ) . The Molecular Basis of GROD-Storing Neuronal Ceroid Lipofuscinoses in Scotland . Molecular Genetics and Metabolism . vol. 66 , 245 - 247 .

Lauronen L, Munroe PB, Järvelä I, Autti T, Mitchison HM, O’Rawe AM, Gardiner RM, Mole SE et al. ( 1999 ) . Delayed classic and protracted phenotypes of compound heterozygous juvenile neuronal ceroid lipofuscinosis . Neurology vol. 52 , ( 2 ) 360 - 365 .

Munroe PB, Olgunturk RO, Fryns J-P, Maldergem LV, Ziereisen F, Yuksel B, Gardiner RM, Chung E ( 1999 ) . Mutations in the gene encoding the human matrix Gla protein cause Keutel syndrome . Nature Genetics vol. 21 , ( 1 ) 142 - 144 .

Freimer NB, Reus VI, Escamilla M, Spesny M, Smith L, Service S, Gallegos A, Meza L et al. ( 1998 ) . An approach to investigating linkage for bipolar disorder using large Costa Rican pedigrees . American Journal of Medical Genetics vol. 67 , ( 3 ) 254 - 263 .

Knowles JA, Fyer AJ, Vieland VJ, Weissman MM, Hodge SE, Heiman GA, Haghighi F, de Jesus GM et al. ( 1998 ) . Results of a genome‐wide genetic screen for panic disorder . American Journal of Medical Genetics vol. 81 , ( 2 ) 139 - 147 .

Escamilla MA, Spesny M, Reus VI, Gallegos A, Meza L, Molina J, Sandkuijl LA, Fournier E et al. ( 1998 ) . Use of linkage disequilibrium approaches to map genes for bipolar disorder in the Costa Rican population . American Journal of Medical Genetics vol. 67 , ( 3 ) 244 - 253 .

Sala E, Warren R, McCann J, Duffy S, Day N, Luben R ( 1998 ) . Mammographic parenchymal patterns and mode of detection: implications for the breast screening programme . Journal of Medical Screening vol. 5 , ( 4 ) 207 - 212 .

Strautnieks SS, Bull LN, Knisely AS, Kocoshis SA, Dahl N, Arnell H, Sokal E, Dahan K et al. ( 1998 ) . A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis . Nature Genetics vol. 20 , ( 3 ) 233 - 238 .

Munroe PB, Greene ND, Leung KY, Mole SE, Gardiner RM, Mitchison HM, Stephenson JB, Crow YJ ( 1998 ) . Sharing of PPT mutations between distinct clinical forms of neuronal ceroid lipofuscinoses in patients from Scotland . Journal of Medical Genetics vol. 35 , ( 9 )

Munroe PB, Strautnieks SS, Farrall M, Daniel HI, Lawson M, DeFreitas P, Fogarty P, Gardiner RM et al. ( 1998 ) . Absence of Linkage of the Epithelial Sodium Channel to Hypertension in Black Caribbeans* . American Journal of Hypertension vol. 11 , ( 8 ) 942 - 945 .

McInnes LA, Reus VI, Freimer NB ( 1998 ) . Mapping genes for psychiatric disorders and behavioral traits . Current Opinion in Genetics & Development vol. 8 , ( 3 ) 287 - 292 .

Bull LN, van Eijk MJT, Pawlikowska L, DeYoung JA, Juijn JA, Liao M, Klomp LWJ, Lomri N et al. ( 1998 ) . A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis . Nature Genetics vol. 18 , ( 3 ) 219 - 224 .

Baharloo S, Johnston PA, Service SK, Gitschier J, Freimer NB ( 1998 ) . Absolute Pitch: An Approach for Identification of Genetic and Nongenetic Components . American Journal of Human Genetics vol. 62 , ( 2 ) 224 - 231 .

Mitchison HM, Hofmann SL, Becerra CHR, Munroe PB, Lake BD, Crow YJ, Stephenson JBP, Williams RE et al. ( 1998 ) . Mutations in the Palmitoyl-Protein Thioesterase Gene (PPT; CLN1) Causing Juvenile Neuronal Ceroid Lipofuscinosis with Granular Osmiophilic Deposits . Human Molecular Genetics vol. 7 , ( 2 ) 291 - 297 .

Mitchison HM, Hofmann SL, Becerra CHR, Munroe PB, Lake BD, Crow YJ, Stephenson JBP, Williams RE et al. ( 1998 ) . Corrigendum: Mutations in the palmitoyl-protein thioesterase gene (PPT; CLN1) causing juvenile neuronal ceroid lipofuscinosis with granular osmiophilic deposits (Human Molecular Genetics (1998) 7 (291-297)) . Human Molecular Genetics vol. 7 , ( 4 )

Bull LN, Freimer NB, Balistreri WF, O'Connell N, Setchell KDR, Kocoshis SA, Putnam PE, Agostini RM et al. ( 1997 ) . A non-Amish infant with true Byler disease . Pediatric Pathology and Laboratory Medicine vol. 17 , ( 3 ) 522 - 523 .

Freimer NB, Service SK, Slatkin M ( 1997 ) . Expanding on population studies . Nature Genetics vol. 17 , ( 4 ) 371 - 373 .

Strautnieks SS, Kagalwalla AF, Tanner MS, Knisely AS, Bull L, Freimer N, Kocoshis SA, Gardiner RM et al. ( 1997 ) . Identification of a Locus for Progressive Familial Intrahepatic Cholestasis PFIC2on Chromosome 2q24 . American Journal of Human Genetics vol. 61 , ( 3 ) 630 - 633 .

Sinke RJ, Carlton VEH, Juijn JA, Delhaas T, Bull L, Henegouwen GPB, van Hattum J, Keller KM et al. ( 1997 ) . Benign recurrent intrahepatic cholestasis (BRIC): evidence of genetic heterogeneity and delimitation of the BRIC locus to a 7-cM interval between D18S69 and D18S64 . Human Genetics vol. 100 , ( 3-4 ) 382 - 387 .

Munroe PB, Mitchison HM, O'Rawe AM, Anderson JW, Boustany R-M, Lerner TJ, Taschner PEM, de Vos N et al. ( 1997 ) . Spectrum of Mutations in the Batten Disease Gene, CLN3 . American Journal of Human Genetics vol. 61 , ( 2 ) 310 - 316 .

Reus VI, Freimer NB ( 1997 ) . Understanding the Genetic Basis of Mood Disorders: Where Do We Stand? . American Journal of Human Genetics vol. 60 , ( 6 ) 1283 - 1288 .

Munroe PB, Strautnieks SS, Farrall M, Daniel HI, Kamdar S, Lawson M, DeFreitas P, Fogarty P et al. ( 1997 ) . Investigation of the epithelial sodium channel (hENaC) as a candidate gene for essential hypertension (EH) in African Caribbeans . American Journal of Hypertension vol. 10 , ( S2 ) 5a - 5a .

Mitchison HM, Munroe PB, O'Rawe AM, Taschner PEM, de Vos N, Kremmidiotis G, Lensink I, Munk AC et al. ( 1997 ) . Genomic Structure and Complete Nucleotide Sequence of the Batten Disease Gene,CLN3 . Genomics vol. 40 , ( 2 ) 346 - 350 .

Daniel H, Munroe P, Kamdar S, Lawson M, Lavender P, Forgaty P, Caulfield M ( 1997 ) . The atrial natriuretic peptide gene and essential hypertension in African-Caribbeans from St Vincent and the Grenadines . Journal of Human Hypertension vol. 11 , ( 2 ) 113 - 117 .

Sela-Herman S, Bull L, Lomri N, Rahmaoui C, Luther T, Hammerman P, Genant J, Freimer N et al. ( 1996 ) . In Search of a Gene for Hereditary Cholestasis . Molecular Genetics and Metabolism vol. 59 , ( 2 ) 98 - 103 .

Järvelä I, Mitchison HM, Munroe PB, O'Rawe AM, Mole SE, Syvänen AC ( 1996 ) . Rapid diagnostic test for the major mutation underlying Batten disease . Journal of Medical Genetics vol. 33 , ( 12 )

McInnes LA, Escamilla MA, Service SK, Reus VI, Leon P, Silva S, Rojas E, Spesny M et al. ( 1996 ) . A complete genome screen for genes predisposing to severe bipolar disorder in two Costa Rican pedigrees . Proceedings of the National Academy of Sciences of the United States of America vol. 93 , ( 23 ) 13060 - 13065 .

Scanlon TJ, Luben R, Lyle P ( 1996 ) . Comparing hypertension guidelines . The BMJ vol. 313 , ( 7066 )

Scanlon TJ, Luben R, Lyle P ( 1996 ) . Comparing hypertension guidelines. Guidelines are based on evidence from trials, not normal practice . BMJ vol. 313 , ( 7066 )

Knisely AS, Kocoshis S, O'Connell N, Setchell KD, Bull LN, Freimer NB ( 1996 ) . 36 DEFICIENCY OF CHENODEOXYCHOLIC ACID IN BILE: BYLER DISEASE AND BYLER SYNDROME . Journal of Pediatric Gastroenterology and Nutrition vol. 23 , ( 3 )

Crouau-Roy B, Service S, Slatkin M, Freimer N ( 1996 ) . A Fine-Scale Comparison of the Human and Chimpanzee Genomes: Linkage, Linkage Disequilibrium and Sequence Analysis . Human Molecular Genetics vol. 5 , ( 8 ) 1131 - 1137 .

Smith LB, Sapers B, Reus VI, Freimer NB ( 1996 ) . Attitudes towards bipolar disorder and predictive genetic testing among patients and providers . Journal of Medical Genetics vol. 33 , ( 7 )

Houwen RHJ, Sinke R, Juyn J, Freimer N, Berger R ( 1996 ) . 22 MAPPING OF THE GENE FOR BRIC AND BYLER DISEASE . Journal of Pediatric Gastroenterology and Nutrition vol. 22 , ( 4 )

Freimer NB, Reus VI, Escamilla MA, Mclnnes LA, Spesny M, Leon P, Service SK, Smith LB et al. ( 1996 ) . Genetic mapping using haplotype, association and linkage methods suggests a locus for severe bipolar disorder (BPI) at 18q22-q23 . Nature Genetics vol. 12 , ( 4 ) 436 - 441 .

Freimer NB, Blower S, Slatkin M ( 1996 ) . Pathogens & strain diversity: Is sex disruptive? . Nature Medicine vol. 2 , ( 4 ) 401 - 403 .

Munroe PB, Mitchison HM, Mole SE, Gardiner RM, Rapola J, Mustonen A, Järvelä I ( 1996 ) . Prenatal diagnosis of Batten's disease . The Lancet vol. 347 , ( 9007 ) 1014 - 1015 .

Garza JC, Freimer NB ( 1996 ) . Homoplasy for size at microsatellite loci in humans and chimpanzees . Genome Research vol. 6 , ( 3 ) 211 - 217 .

Di Rienzo A, Peterson AC, Freimer NB ( 1995 ) . Amplification with Arbitrary Primers . Methods in Molecular Biology vol. 54 , 123 - 129 .

JÄRVELÄ IE, MITCHISON HM, O'RAWE AM, MUNROE PB, TASCHNER PEM, DEVOS N, LERNER TJ, D'ARIGO KL et al. ( 1995 ) . YAC and Cosmid Contigs Spanning the Batten Disease (CLN3) Region at 16p12.1–p11.2 . Genomics vol. 29 , ( 2 ) 478 - 489 .

Munroe PB, Daniel HI, Farrall M, Lawson M, Bouloux PM, Caulfield MJ ( 1995 ) . Absence of genetic linkage between polymorphisms of the insulin receptor gene and essential hypertension . Journal of Human Hypertension . vol. 9 , 669 - 670 .

Garza JC, Slatkin M, Freimer NB ( 1995 ) . Microsatellite allele frequencies in humans and chimpanzees, with implications for constraints on allele size . Molecular Biology and Evolution vol. 12 , ( 4 ) 594 - 603 .

McInnes LA, Freimer NB ( 1995 ) . Mapping genes for psychiatric disorders and behavioral traits . Current Opinion in Genetics & Development vol. 5 , ( 3 ) 376 - 381 .

Carlton VEH, Knisely AS, Freimer NB ( 1995 ) . Mapping of a locus for progressive familial intrahepatic cholestasis (Byler disease) to 18q21-q22, the benign recurrent intrahepatic cholestasis region . Human Molecular Genetics vol. 4 , ( 6 ) 1049 - 1053 .

Peterson AC, Di Rienzo A, Lehesjokl A-E, de la Chapelle A, Slatkin M, Frelmer NB ( 1995 ) . The distribution of linkage disequilibrium over anonymous genome regions . Human Molecular Genetics vol. 4 , ( 5 ) 887 - 894 .

Houwen RHJ, Baharloo S, Blankenship K, Raeymaekers P, Juyn J, Sandkuijl LA, Freimer NB ( 1994 ) . Genome screening by searching for shared segments: mapping a gene for benign recurrent intrahepatic cholestasis . Nature Genetics vol. 8 , ( 4 ) 380 - 386 .

Dooley TP, Probst P, Munroe PB, Mole SE, Liu Z, Doggett NA ( 1994 ) . Genomic Organization and DNA Sequence of the Human Catecholamine-Sulfating Phenol Sulfotransferase Gene (STM) . Biochemical and Biophysical Research Communications vol. 205 , ( 2 ) 1325 - 1332 .

Dooley TP, Mitchison HM, Munroe PB, Probst P, Neal M, Siciliano MJ, Deng ZM, Doggett NA et al. ( 1994 ) . Mapping of Two Phenol Sulfotransferase Genes, STP and STM, to 16p: Candidate Genes for Batten Disease . Biochemical and Biophysical Research Communications vol. 205 , ( 1 ) 482 - 489 .

Kamdar S, Daniel H, Fogarty P, Lawson M, Munroe P, Caulfield M ( 1994 ) . ACE insertion/deletion (I/D) polymorphism in Vincentian African Caribbeans with essential hypertension . Journal of Human Hypertension . vol. 8 ,

Munroe PB, Johnston A, Duke VM, Daniel HI, Bouloux PM, Lawson M, Caulfield MJ ( 1994 ) . Investigation of lipoprotein lipase (LPL) as a candidate gene for dyslipidaemic hypertension . Journal of Human Hypertension . vol. 8 , 613 - 614 .

Daniel HI, Munroe PB, Lawson M, Fogarty P, Kamdar SM, Caulfield MJ ( 1994 ) . Investigation of the renin gene as a putative locus for essential hypertension (EH) in Vincentian African Caribbeans . Journal of Human Hypertension . vol. 8 , 609 - 610 .

Caulfield M, Lavender P, Farrall M, Munroe P, Lawson M, Turner P, Clark A ( 1994 ) . Linkage of the Angiotensinogen Gene to Essential Hypertension . New England Journal of Medicine vol. 330 , ( 23 ) 1629 - 1633 .

Di Rienzo A, Peterson AC, Garza JC, Valdes AM, Slatkin M, Freimer NB ( 1994 ) . Mutational processes of simple-sequence repeat loci in human populations . Proceedings of the National Academy of Sciences of the United States of America vol. 91 , ( 8 ) 3166 - 3170 .

Scanlon TJ, Luben RN, Scanlon FL, Singleton N ( 1993 ) . Is Friday the 13th bad for your health? . The BMJ vol. 307 , ( 6919 )

Di Rienzo A, Peterson A, Das S, Freimer NB ( 1993 ) . Genome mapping by arbitrary amplification of yeast artificial chromosomes . Mammalian Genome vol. 4 , ( 7 ) 359 - 363 .

Freimer NB, Sandkuijl LA, Blower SM ( 1993 ) . Incorrect specification of marker allele frequencies: effects on linkage analysis . American Journal of Human Genetics vol. 52 , ( 6 ) 1102 - 1110 .

Valdes AM, Slatkin M, Freimer NB ( 1993 ) . Allele frequencies at microsatellite loci: the stepwise mutation model revisited . Genetics vol. 133 , ( 3 ) 737 - 749 .

Munroe PB, Caulfield M, Daniel H, Lawson M, Bouloux PMG, Turner P ( 1993 ) . Analysis of the insulin receptor RsaI polymorphism in essential hypertension . British Journal of Clinical Pharmacology . vol. 35 ,

Bouloux PM, Munroe P, Kirk J, Besser GM ( 1992 ) . Sex and smell – an enigma resolved . Journal of Endocrinology vol. 133 , ( 3 ) 323 - 326 .

Consalez GG, Stayton CL, Freimer NB, Goonewardena P, Brown WT, Gilliam TC, Warren ST ( 1992 ) . Isolation and characterization of a highly polymorphic human locus (DXS455) in proximal Xq28 . Genomics vol. 12 , ( 4 ) 710 - 714 .

Bouloux P-MG, Hardelin J-P, Munroe P, Kirk JMW, Legouis R, Levilliers J, Hazan J, Weissenbach J et al. ( 1991 ) . A dinucleotide repeat polymorphism at the Kallmann locus (Xp22.3) . Nucleic Acids Research vol. 19 , ( 19 ) 5453 - 5453 .

Kleyn PW, Brzustowicz LM, Wilhelmsen KC, Freimer NB, Miller JM, Munsat TL, Gilliam TC ( 1991 ) . Spinal muscular atrophy is not the result of mutations at the beta-hexosaminidase or GM2-activator locus . Neurology vol. 41 , ( 9 ) 1418 - 1422 .

Gilliam TC, Freimer NB, Kaufmann CA, Powchik PP, Bassett AS, Bengtsson U, Wasmuth JJ ( 1989 ) . Deletion mapping of DNA markers to a region of chromosome 5 that cosegregates with schizophrenia . Genomics vol. 5 , ( 4 ) 940 - 944 .

Freimer N, Lu F, Chen J ( 1989 ) . Posttraumatic Stress and Conversion Disorders in a Laotian Refugee Veteran: Use of Amobarbital Interviews . The Journal of Nervous and Mental Disease vol. 177 , ( 7 ) 432 - 433 .