Publications: Prof Patricia Munroe

Burns R, Young WJ, Aung N, Lopes LR, Elliott PM, Syrris P, Barriales-Villa R, Sohrabi C et al. ( 2024 ) . Genetic basis of right and left ventricular heart shape . Nature Communications vol. 15 , ( 1 )

Shah R, Kirkby C, Ives C, Lowe M, Munroe PB, Lambiase PD, Young WJ ( 2024 ) . Can variants of genes associated with familial heart block predict conduction disease in the general population? A UK Biobank study . European Heart Journal vol. 45 , ( Supplement_1 )

Young W, Sanghvi MM, Ramirez J, Orini M, Tinker A, Warren HR, Lambiase PD, Munroe PB ( 2024 ) . Circulating metabolites associate with the QT interval in individuals without prevalent cardiovascular disease . European Heart Journal vol. 45 , ( Supplement_1 )

Misghina S, Rauseo E, Barrera CE, Vigmond EJ, Slabaugh G, Aung N, Petersen SE, Munroe PB et al. ( 2024 ) . In-silico insights into personalised therapy selection of anti-arrhythmic drugs and ablation using patient-specific biatrial models for atrial fibrillation . European Heart Journal . vol. 45 ,

Ramirez J, Martinez JP, Van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB et al. ( 2024 ) . Long-term time-to-ventricular arrhythmic event prediction using a deep learning based model on the electrocardiogram signal . European Heart Journal vol. 45 , ( Supplement_1 )

Sanghvi MM, Young WJ, Chadalavada S, Petersen SE, Aung N, Munroe PB ( 2024 ) . Non-lipid metabolomic biomarkers are associated with adverse cardiac remodelling and cardiovascular outcomes . European Heart Journal . vol. 45 ,

Sanghvi MM, Chadalavada S, Aung N, Munroe PB, Donos N, Petersen SE ( 2024 ) . The association between periodontal disease and coronary artery disease: insights from imaging, observational and genome-wide data . European Heart Journal . vol. 45 ,

Van Duijvenboden S, Nicholson G, Smith-Byrne K, Portas L, Atkins J, Ramirez J, Orini M, Young WJ et al. ( 2024 ) . The genetic architecture of exercise-induced ventricular ectopy . European Heart Journal vol. 45 , ( Supplement_1 )

Asatryan B, Murray B, Tadros R, Rieder M, Shah RA, Sharaf Dabbagh G, Landstrom AP, Dobner S et al. ( 2024 ) . Promise and Peril of a Genotype-First Approach to Mendelian Cardiovascular Disease . Journal of the American Heart Association vol. 13 , ( 21 )

Naderi H, Yang Y-H, Munroe PB, Petersen SE, Westwood M, Aung N ( 2024 ) . Health data science course for clinicians: Time to bridge the skills gap? . Perfusion

Sanghvi MM, Ramírez J, Chadalavada S, Aung N, Munroe PB, Donos N, Petersen SE ( 2024 ) . The Association Between Periodontal Disease and Cardiovascular Disease Insights From Imaging, Observational, and Genetic Data . JACC Advances vol. 3 , ( 10 )

Young WJ, van der Most PJ, Bartz TM, Bos MM, Biino G, Duong T, Foco L, Lominchar JT et al. ( 2024 ) . Genome-Wide Interaction Analyses of Serum Calcium on Ventricular Repolarization Time in 125 393 Participants . Journal of the American Heart Association vol. 13 , ( 17 )

Aung N, Nicholls HL, Chahal CAA, Khanji MY, Rauseo E, Chadalavada S, Petersen SE, Munroe PB et al. ( 2024 ) . Prevalence, Cardiac Phenotype, and Outcomes of Transthyretin Variants in the UK Biobank Population . JAMA Cardiology vol. 9 , ( 11 )

Collaboration NRF, Zhou B, Bennett JE, Wickham AP, Singleton RK, Mishra A, Carrillo-Larco RM, Ikeda N et al. ( 2024 ) . General and abdominal adiposity and hypertension in eight world regions: a pooled analysis of 837 population-based studies with 7·5 million participants . The Lancet vol. 404 , ( 10455 ) 851 - 863 .

Gomez EA, De Matteis R, Udomjarumanee P, Team GAHR, Akhtar S, Anwar M, Arciero E, Asgar O et al. ( 2024 ) . An LGR6 frameshift variant abrogates receptor expression on select leukocyte subsets and is associated with viral infections . Blood vol. 144 , ( 4 ) 420 - 434 .

Ramírez J, van Duijvenboden S, Young WJ, Chen Y, Usman T, Orini M, Lambiase PD, Tinker A et al. ( 2024 ) . Fine mapping of candidate effector genes for heart rate . Human Genetics vol. 143 , ( 9-10 ) 1207 - 1221 .

Madrid J, Munroe P, Duijvenboden S, Mincholé A, Ramírez J ( 2024 ) . ECG-based unsupervised clustering in coronary artery disease associates with cardiovascular events . Journal of Electrocardiology vol. 85 , 3 - 4 .

Tsisanova E, Nobles M, Sebastian S, Ng K-E, Thomas A, Weinstein LS, Munroe PB, Tinker A ( 2024 ) . The ric-8b protein (resistance to inhibitors of cholinesterase 8b) is key to preserving contractile function in the adult heart . Journal of Biological Chemistry vol. 300 , ( 7 )

Nicholls HL, Vargas J, Chahal A, Khanji M, Petersen S, Munroe P, Aung N ( 2024 ) . Common and rare variant association study of left and right ventricular phenotypes identifies novel genetic loci and therapeutic targets for heart failure . Conference: European Society of Human Genetics ( Berlin, Germany ) from: 01/06/2024 to: 04/06/2024 ,

Nicholls H, Vargas J, Chahal A, Khanji M, Petersen S, Munroe P, Aung N ( 2024 ) . Common and rare variant association study of left and right ventricular phenotypes identifies novel genetic loci and therapeutic targets for heart failure . Conference: Londomics Symposium from: 20/05/2024 to: 20/05/2024 ,

Ramírez J, Young WJ, van Duijvenboden S, Munroe PB ( 2024 ) . PO-01-089 PREDICTION OF ATRIAL AND VENTRICULAR ARRHYTHMIAS USING MULTIPLE CARDIOVASCULAR RISK FACTOR POLYGENIC RISK SCORES . Heart Rhythm vol. 21 , ( 5 )

Madrid J, van Duijvenboden S, Munroe PB, Minchole A, Ramírez J ( 2024 ) . PO-02-049 ECG-BASED UNSUPERVISED CLUSTERING IN CORONARY ARTERY DISEASE DETECTS AND PREDICTS HEART FAILURE . Heart Rhythm vol. 21 , ( 5 )

Misghina SB, Solis-Lemus JA, Lopez-Barrera CE, Rauseo E, Vigmond EJ, Niederer SA, Aung N, Munroe PB et al. ( 2024 ) . PO-05-033 PATIENT-SPECIFIC BIATRIAL MODELLING FRAMEWORK FOR PREDICTING ATRIAL FIBRILLATION OUTCOMES . Heart Rhythm vol. 21 , ( 5 ) s565 - s566 .

Keaton JM, Kamali Z, Xie T, Vaez A, Williams A, Goleva SB, Ani A, Evangelou E et al. ( 2024 ) . Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits . Nature Genetics vol. 56 , ( 5 ) 778 - 791 .

Lau CE, Manou M, Markozannes G, Ala‐Korpela M, Ben‐Shlomo Y, Chaturvedi N, Engmann J, Gentry‐Maharaj A et al. ( 2024 ) . NMR metabolomic modeling of age and lifespan: A multicohort analysis . Aging Cell vol. 23 , ( 7 )

Breeyear JH, Mautz BS, Keaton JM, Hellwege JN, Torstenson ES, Liang J, Bray MJ, Giri A et al. ( 2024 ) . A new test for trait mean and variance detects unreported loci for blood-pressure variation . American Journal of Human Genetics vol. 111 , ( 5 ) 954 - 965 .

Ganji-Arjenaki M, Kamali Z, Pressure ICOB, Evangelou E, Warren HR, Gao H, Ntritsos G, Dimou N et al. ( 2024 ) . Prioritization of Kidney Cell Types Highlights Myofibroblast Cells in Regulating Human Blood Pressure . Kidney International Reports vol. 9 , ( 6 ) 1849 - 1859 .

Munroe PB, Aung N, Ramírez J ( 2024 ) . Genetic analysis of cardiac dynamic flow volumes identifies loci mapping aortic root size . Nature Genetics vol. 56 , ( 2 ) 197 - 199 .

Guirette M, Lan J, McKeown NM, Brown MR, Chen H, de Vries PS, Kim H, Rebholz CM et al. ( 2024 ) . Genome-Wide Interaction Analysis With DASH Diet Score Identified Novel Loci for Systolic Blood Pressure . Hypertension vol. 81 , ( 3 ) 552 - 560 .

Olczak K, Ahmed F, Munroe PB ( 2024 ) . Chapter 17 Disorders manifesting with systemic hypertension . Genomic and Molecular Cardiovascular Medicine , Elsevier

Sanghvi M, Ramirez J, Petersen S, Aung N, Munroe P ( 2024 ) . Kiosk 11R-TC-05 Investigation of the Modulatory Effect of Physical Activity on Genetic Variants Associated with Left Ventricular Mass . Journal of Cardiovascular Magnetic Resonance vol. 26 ,

Ramírez J, Miguel A, van Duijvenboden S, Orini M, Young WJ, Tinker A, Lambiase PD, Munroe PB et al. ( 2023 ) . A Multilayer CNN Using the ECG, Age and Sex Predicts Ventricular Arrhythmias in the General Population . 2016 Computing in Cardiology Conference (CinC) . Conference: 2023 Computing in Cardiology Conference (CinC) vol. 50 , 1 - 4 .

Madrid J, Munroe PB, van Duijvenboden S, Ramírez J, Mincholé A ( 2023 ) . ECG-Based Unsupervised Clustering in Coronary Artery Disease Associates with Ventricular Arrhythmia . 2016 Computing in Cardiology Conference (CinC) . Conference: 2023 Computing in Cardiology Conference (CinC) vol. 50 , 1 - 4 .

Orini M, van Duijvenboden S, Ramírez J, Young W, Tinker A, Munroe PB, Lambiase PD ( 2023 ) . Ultra-Short Beat-to-Beat Repolarization Variability Predicts Cardiovascular Events in Individuals Without Cardiovascular Disease . 2016 Computing in Cardiology Conference (CinC) . Conference: 2023 Computing in Cardiology Conference (CinC) vol. 50 , 1 - 4 .

Guirette M, Lan J, Mckeown N, Brown MR, Chen H, De Vries PS, Kim H, Rebholz CM et al. ( 2023 ) . Genome-Wide Interaction Analysis with DASH Diet Score Identified Novel Loci for Systolic Blood Pressure . vol. 4 , ( 11-20 )

Ramirez J, Martinez JP, Van Duijvenboden S, Tinker A, Lambiase P, Orini M, Munroe PB, Miguel A ( 2023 ) . Combining hypothesis-driven ECG indices with machine learning improves ventricular arrhythmic risk prediction in a low-risk population . European Heart Journal vol. 44 , ( Supplement_2 )

Orini M, Van Duijvenboden S, Young WJ, Ramirez J, Jones AR, Tinker A, Munroe PB, Lambiase PD ( 2023 ) . Ultra-short heart rate variability over 15 seconds is associated with increased long-term risk of cardiovascular disease . European Heart Journal vol. 44 , ( Supplement_2 )

Lau C-HE, Manou M, Markozannes G, Ala-Korpela M, Shlomo YB, Chaturvedi N, Engmann J, Gentry-Maharaj A et al. ( 2023 ) . NMR metabolomic modelling of age and lifespan: a multi-cohort analysis . vol. 4 , ( 11-20 )

Orini M, van Duijvenboden S, Young WJ, Ramírez J, Jones AR, Hughes AD, Tinker A, Munroe PB et al. ( 2023 ) . Long-term association of ultra-short heart rate variability with cardiovascular events . Scientific Reports vol. 13 , ( 1 )

de las Fuentes L, Schwander KL, Brown MR, Bentley AR, Winkler TW, Sung YJ, Munroe PB, Miller CL et al. ( 2023 ) . Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci . Frontiers in Genetics vol. 14 ,

Willems SM, Ng NHJ, Fernandez J, Fine RS, Wheeler E, Wessel J, Kitajima H, Marenne G et al. ( 2023 ) . Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization . Wellcome Open Research vol. 8 ,

van Duijvenboden S, Ramírez J, Orini M, Aung N, Petersen SE, Doherty A, Tinker A, Munroe PB et al. ( 2023 ) . Prognostic Significance of Different Ventricular Ectopic Burdens During Submaximal Exercise in Asymptomatic UK Biobank Subjects . Circulation vol. 148 , ( 24 ) 1932 - 1944 .

Simon J, Fung K, Raisi-Estabragh Z, Aung N, Khanji MY, Zsarnóczay E, Merkely B, Munroe PB et al. ( 2023 ) . Association between subclinical atherosclerosis and cardiac structure and function—results from the UK Biobank Study . European Heart Journal - Imaging Methods and Practice vol. 1 , ( 2 )

Asatryan B, Shah RA, Dabbagh GS, Landstrom AP, Darbar D, Khanji MY, Lopes LR, van Duijvenboden S et al. ( 2023 ) . Predicted Deleterious Variants in Cardiomyopathy Genes Prognosticate Mortality and Composite Outcomes in the UK Biobank . JACC Heart Failure vol. 12 , ( 5 ) 918 - 932 .

Lagou V, Jiang L, Ulrich A, Zudina L, González KSG, Balkhiyarova Z, Faggian A, Maina JG et al. ( 2023 ) . GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification . Nature Genetics vol. 55 , ( 9 ) 1448 - 1461 .

van Duijvenboden S, Ramírez J, Young WJ, Olczak KJ, Ahmed F, Alhammadi MJAY, Pressure ICOB, Bell CG et al. ( 2023 ) . Integration of genetic fine-mapping and multi-omics data reveals candidate effector genes for hypertension . American Journal of Human Genetics vol. 110 , ( 10 ) 1718 - 1734 .

van de Vegte YJ, Eppinga RN, van der Ende MY, Hagemeijer YP, Mahendran Y, Salfati E, Smith AV, Tan VY et al. ( 2023 ) . Genetic insights into resting heart rate and its role in cardiovascular disease . Nature Communications vol. 14 , ( 1 )

Petersen S, Aung N, Munroe P, Raisi Estabragh Z ( 2023 ) . Association of longer leukocyte telomere length with cardiac size, function, and heart failure . JAMA Cardiology

Rasooly D, Peloso GM, Pereira AC, Dashti H, Giambartolomei C, Wheeler E, Aung N, Ferolito BR et al. ( 2023 ) . Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure . Nature Communications vol. 14 , ( 1 )

Naderi H, Ramirez J, Van Duijvenboden S, Ruiz Pujadas E, Aung N, Wang L, Chahal CAA, Lekadir K et al. ( 2023 ) . Classifying hypertension mediated left ventricular hypertrophy phenotypes from the 12-lead electrocardiogram using machine learning . European Heart Journal - Cardiovascular Imaging vol. 24 , ( Supplement_1 )

Sanghvi MM, Aung N, Ramirez J, Munroe PB, Petersen SE ( 2023 ) . The association between non-lipid metabolomic biomarkers and prognostically important left ventricular phenotypes . European Heart Journal - Cardiovascular Imaging vol. 24 , ( Supplement_1 )

Munroe P ( 2023 ) . Predicting left ventricular hypertrophy from the 12-lead electrocardiogram in the UK Biobank imaging study using machine learning . European Heart Journal – Digital Health

Graham SE, Clarke SL, Wu K-HH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I et al. ( 2023 ) . Author Correction: The power of genetic diversity in genome-wide association studies of lipids . Nature vol. 618 , ( 7965 ) e19 - e20 .

Young WJ, Haessler J, Benjamins J-W, Repetto L, Yao J, Isaacs A, Harper AR, Ramirez J et al. ( 2023 ) . Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease . Nature Communications vol. 14 , ( 1 )

Orini M, van Duijvenboden S, Young WJ, Ramírez J, Jones AR, Tinker A, Munroe PB, Lambiase PD ( 2023 ) . Premature atrial and ventricular contractions detected on wearable-format electrocardiograms and prediction of cardiovascular events . European Heart Journal - Digital Health vol. 4 , ( 2 ) 112 - 118 .

Aung N, Lopes LR, van Duijvenboden S, Harper AR, Goel A, Grace C, Ho CY, Weintraub WS et al. ( 2023 ) . Genome-Wide Analysis of Left Ventricular Maximum Wall Thickness in the UK Biobank Cohort Reveals a Shared Genetic Background With Hypertrophic Cardiomyopathy . Circulation Genomic and Precision Medicine vol. 16 , ( 1 )

Orini M, van Duijvenboden S, Tinker A, Munroe P, Lambiase P ( 2022 ) . Association Between Photoplethysmography Pulse Upslope and Cardiovascular Events in over 170,000 UK Biobank Participants . 2016 Computing in Cardiology Conference (CinC) . Conference: 2022 Computing in Cardiology Conference (CinC) vol. 00 , 1 - 4 .

Orini M, van Duijvenboden S, Ramírez J, Tinker A, Munroe P, Lambiase P ( 2022 ) . Uncoupling Between Heart Rate Variability and Heart Rate During Exercise and Recovery as a Predictor of Cardiovascular Events . 2016 Computing in Cardiology Conference (CinC) . Conference: 2022 Computing in Cardiology Conference (CinC) vol. 498 , 1 - 4 .

Kanoni S, Graham SE, Wang Y, Surakka I, Ramdas S, Zhu X, Clarke SL, Bhatti KF et al. ( 2022 ) . Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis . Genome Biology vol. 23 , ( 1 )

Machlitt-Northen S, Keers R, Munroe PB, Howard DM, Pluess M ( 2022 ) . Polygenic risk scores for schizophrenia and major depression are associated with socio-economic indicators of adversity in two British community samples . Translational Psychiatry vol. 12 , ( 1 )

Sebastian S, Weinstein LS, Ludwig A, Munroe P, Tinker A ( 2022 ) . Slowing Heart Rate Protects Against Pathological Cardiac Hypertrophy . Function vol. 4 , ( 1 )

Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen AU et al. ( 2022 ) . A saturated map of common genetic variants associated with human height . Nature vol. 610 , ( 7933 ) 704 - 712 .

Petersen S, Raisi Estabragh Z, Munroe P ( 2022 ) . Incident clinical and mortality associations of myocardial native T1 in the UK Biobank: A prospective observational study . JACC: Cardiovascular Imaging

Young WJ, Lahrouchi N, Isaacs A, Duong T, Foco L, Ahmed F, Brody JA, Salman R et al. ( 2022 ) . Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways . Nature Communications vol. 13 , ( 1 )

Ramírez J, Kiviniemi A, van Duijvenboden S, Tinker A, Lambiase PD, Junttila J, Perkiömäki JS, Huikuri HV et al. ( 2022 ) . ECG T‐Wave Morphologic Variations Predict Ventricular Arrhythmic Risk in Low‐ and Moderate‐Risk Populations . Journal of the American Heart Association vol. 11 , ( 17 )

Ramdas S, Judd J, Graham SE, Kanoni S, Wang Y, Surakka I, Wenz B, Clarke SL et al. ( 2022 ) . A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids . American Journal of Human Genetics vol. 109 , ( 8 ) 1366 - 1387 .

Ramírez J, Van Duijvenboden S, Young W, Tinker A, Lambiase P, Orini M, Munroe P ( 2022 ) . Prediction of coronary artery disease and major adverse cardiovascular events using clinical and genetic risk scores for cardiovascular risk factors . Atherosclerosis vol. 355 , 3 - 4 .

Ramírez J, van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB ( 2022 ) . Prediction of Coronary Artery Disease and Major Adverse Cardiovascular Events Using Clinical and Genetic Risk Scores for Cardiovascular Risk Factors . Circulation Genomic and Precision Medicine vol. 15 , ( 5 ) e003441 - e003441 .

Machlitt‐Northen S, Keers R, Munroe PB, Howard DM, Trubetskoy V, Pluess M ( 2022 ) . Polygenic scores for schizophrenia and major depression are associated with psychosocial risk factors in children: evidence of gene–environment correlation . Journal of Child Psychology and Psychiatry vol. 63 , ( 10 ) 1140 - 1152 .

Machlitt-Northen S, Keers R, Munroe PB, Howard DM, Pluess M ( 2022 ) . Gene–Environment Correlation over Time: A Longitudinal Analysis of Polygenic Risk Scores for Schizophrenia and Major Depression in Three British Cohorts Studies . Genes vol. 13 , ( 7 )

Shah RA, Asatryan B, Dabbagh GS, Aung N, Khanji MY, Lopes LR, van Duijvenboden S, Holmes A et al. ( 2022 ) . Frequency, Penetrance, and Variable Expressivity of Dilated Cardiomyopathy–Associated Putative Pathogenic Gene Variants in UK Biobank Participants . Circulation vol. 146 , ( 2 ) 110 - 124 .

Raisi-Estabragh Z, McCracken C, Condurache DG, Aung N, Vargas JD, Naderi H, Munroe PB, Neubauer S et al. ( 2022 ) . Corrigendum to: Left atrial structure and function are associated with cardiovascular outcomes independent of left ventricular measures: a UK Biobank CMR study . European Heart Journal - Cardiovascular Imaging vol. 23 , ( 9 ) e331 - e331 .

Petersen S, Aung N, Munroe P ( 2022 ) . Genome-wide association analysis reveals insights into the genetic architecture of right ventricular structure and function . Nature Genetics

Rezaei MJ, Woodward JR, Ramirez J, Munroe P ( 2022 ) . Combination of Isolation Forest, SMOTE and Ensemble Learning for the classification of Atrial Fibrillation and Ventricular Arrhythmia . Conference: 2021 International Conference on Biomedical Innovations and Applications (BIA) vol. 1 , 45 - 50 .

Kelly TN, Sun X, He KY, Brown MR, Taliun SAG, Hellwege JN, Irvin MR, Mi X et al. ( 2022 ) . Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension . Hypertension vol. 79 , ( 8 ) 1656 - 1667 .

Naderi H, Ramírez J, Van Duijvenboden S, Aung N, Fung K, Young W, Petersen S, Munroe P ( 2022 ) . PREDICTING THE PATTERN OF ANATOMICAL LEFT VENTRICULAR HYPERTROPHY USING ELECTROPHYSIOLOGICAL BIOMARKERS FROM THE ECG QRS COMPLEX IN HYPERTENSIVE INDIVIDUALS FROM UK BIOBANK . Journal of Hypertension . vol. 40 ,

Shah R, Asatryan B, Dabbagh GS, Khanji M, van Duijvenboden S, Muser D, Landstrom AP, Semsarian C et al. ( 2022 ) . EN-571-02 SCREENING FOR PUTATIVE PATHOGENIC VARIANTS IN DILATED CARDIOMYOPATHY GENES IDENTIFIES EARLY DISEASE AND PREDICTS MORTALITY . Heart Rhythm vol. 19 , ( 5 ) s101 - s102 .

Calabrese C, Pyle A, Griffin H, Coxhead J, Hussain R, Braund PS, Li L, Burgess A et al. ( 2022 ) . Heteroplasmic mitochondrial DNA variants in cardiovascular diseases . PLOS Genetics vol. 18 , ( 4 )

Jepson RE, Warren H, Wallace MD, Syme HM, Elliott J, Munroe PB ( 2022 ) . First genome-wide association study investigating blood pressure and renal traits in domestic cats . Scientific Reports vol. 12 , ( 1 )

Taylor-Bateman V, Gill D, Georgakis MK, Malik R, Munroe P, Traylor M, Evangelou E, Warren HR et al. ( 2022 ) . Cardiovascular Risk Factors and MRI Markers of Cerebral Small Vessel Disease . Neurology vol. 98 , ( 4 ) e343 - e351 .

Petersen S, Aung N, Khanji M, Fung K, Raisi-Estabragh Z, Munroe P ( 2022 ) . Light to moderate coffee consumption is associated with lower risk of death: a UK Biobank study . European Journal of Preventive Cardiology

Trompet S, Postmus I, Warren HR, Noordam R, Smit RAJ, Theusch E, Li X, Arsenault B et al. ( 2022 ) . The Pharmacogenetics of Statin Therapy on Clinical Events: No Evidence that Genetic Variation Affects Statin Response on Myocardial Infarction . Frontiers in Pharmacology vol. 12 ,

Naderi H, Ramirez J, van Duijvenboden S, Ruiz Pujadas E, Wang L, Lekadir K, Petersen S, Munroe P ( 2022 ) . Classifying hypertension mediated left ventricular hypertrophy patterns from the electrocardiogram using machine learning . JOURNAL OF HUMAN HYPERTENSION . vol. 36 , 4 - 4 .

Warren H, Keaton J, Kamali Z, Vaez A, Xie T, Ani A, Evangelou E, Levy D et al. ( 2022 ) . Genome-wide analysis in over 1 million individuals reveals over 2,000 independent genetic signals for blood pressure . JOURNAL OF HUMAN HYPERTENSION . vol. 36 , 7 - 8 .

Olczak K, Aziz Q, Sebastian S, Rajeeve V, Otunsola R, Tinker A, Munroe P ( 2022 ) . Investigating the potential role of R-Ras in blood pressure control . JOURNAL OF HUMAN HYPERTENSION . vol. 36 , 2 - 3 .

Olczak KJ, Aziz Q, Sebastian S, Tinker A, Munroe PB ( 2022 ) . Investigating the potential role of the small GTPase R-Ras in mechanisms of blood pressure control . ACTA PHYSIOLOGICA . vol. 236 , 543 - 543 .

Ramirez J, van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB ( 2022 ) . Prediction of coronary artery disease: Do risk factor genetic risk scores add value? . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 30 , 188 - 189 .

Young WJ, Munroe PB, Tereshchenko L ( 2022 ) . Trans-ancestry GWAS of 118,780 individuals reveals biological mechanisms underlying the spatial QRS-T angle, a marker of arrhythmogenesis . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 30 , 599 - 599 .

Raisi-Estabragh Z, Harvey NC, Munroe P ( 2021 ) . Novel determinants of Cardiovascular disease: a population approach .

Raisi-Estabragh Z, Jaggi A, Gkontra P, McCracken C, Aung N, Munroe PB, Neubauer S, Harvey NC et al. ( 2021 ) . Cardiac Magnetic Resonance Radiomics Reveal Differential Impact of Sex, Age, and Vascular Risk Factors on Cardiac Structure and Myocardial Tissue . Frontiers in Cardiovascular Medicine vol. 8 ,

Petersen S, Munroe P, Aung N, Raisi-Estabragh Z ( 2021 ) . Left atrial structure and function are associated with cardiovascular outcomes independent of left ventricular measures: a UK Biobank CMR study . European Heart Journal: Cardiovascular Imaging

Graham SE, Clarke SL, Wu K-HH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I et al. ( 2021 ) . The power of genetic diversity in genome-wide association studies of lipids . Nature vol. 600 , ( 7890 ) 675 - 679 .

Shah R, Asatryan B, Dabbagh GS, Aung N, Khanji MY, Lopes LR, van Duijvenboden S, Holmes A et al. ( 2021 ) . The Frequency, Penetrance and Variable Expressivity of Dilated Cardiomyopathy-Associated Putative Pathogenic Gene Variants in UK Biobank Participants .

Fung K, Biasiolli L, Hann E, Lukaschuk E, Ramírez J, van Duijvenboden S, Aung N, Paiva JM et al. ( 2021 ) . 9 Identification of thirty novel loci for cardiovascular magnetic resonance derived aortic distensibility in the UK Biobank . Heart . Conference: BSCMR 2021 vol. 107 , a6 - a8 .

Simon J, Fung K, Raisi-Estabragh Z, Aung N, Khanji MY, Kolossvary M, Merkely B, Munroe PB et al. ( 2021 ) . Association of daily coffee consumption with cardiovascular health – results from the UK Biobank . European Heart Journal vol. 42 , ( Supplement_1 )

McDonough CW, Warren HR, Jack JR, Motsinger‐Reif AA, Armstrong ND, Bis JC, House JS, Singh S et al. ( 2021 ) . Adverse Cardiovascular Outcomes and Antihypertensive Treatment: A Genome‐Wide Interaction Meta‐Analysis in the International Consortium for Antihypertensive Pharmacogenomics Studies . Clinical Pharmacology & Therapeutics vol. 110 , ( 3 ) 723 - 732 .

Young W, Isaacs A, Lahrouchi N, Mifsud B, Munroe PB, Newton-Cheh CH, Sotoodehnia N, group OTCEW ( 2021 ) . B-011-01 TRANS-ANCESTRY GWAS OF 252,730 INDIVIDUALS IDENTIFIES 114 NOVEL LOCI ASSOCIATED WITH THE QT INTERVAL . Heart Rhythm vol. 18 , ( 8 )

Young W, Isaacs A, Lahrouchi N, Mifsud B, Munroe PB, Newton-Cheh CH, Sotoodehnia N, group OTCEW ( 2021 ) . B-AB13-01 TRANS-ANCESTRY GWAS OF 252,730 INDIVIDUALS IDENTIFIES 114 NOVEL LOCI ASSOCIATED WITH THE QT INTERVAL . Heart Rhythm vol. 18 , ( 8 )

van Duijvenboden S, Ramírez J, Young WJ, Orini M, Mifsud B, Tinker A, Lambiase PD, Munroe PB ( 2021 ) . Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders . Human Molecular Genetics vol. 30 , ( 24 ) 2513 - 2523 .

Olczak KJ, Taylor‐Bateman V, Nicholls HL, Traylor M, Cabrera CP, Munroe PB ( 2021 ) . Hypertension genetics past, present and future applications . Journal of Internal Medicine vol. 290 , ( 6 ) 1130 - 1152 .

Petersen S, Munroe P, Pugliese F, Lee A, Raisi-Estabragh Z ( 2021 ) . Automated quality-controlled cardiovascular magnetic resonance pericardial fat quantification using a convolutional neural network in the UK Biobank . Frontiers in Cardiovascular Medicine

Ramírez J, van Duijvenboden S, Young WJ, Orini M, Jones AR, Lambiase PD, Munroe PB, Tinker A ( 2021 ) . Analysing electrocardiographic traits and predicting cardiac risk in UK biobank . JRSM Cardiovascular Disease vol. 10 ,

Raisi-Estabragh Z, Martineau A, Curtis E, Moon R, Darling A, Lanham-New S, Ward K, Cooper C et al. ( 2021 ) . Vitamin D and coronavirus disease 2019 (COVID-19): rapid evidence review . Aging Clinical and Experimental Research

van Duijvenboden S, Ramirez J, Orini M, Tinker A, Munroe P, Lambiase P ( 2021 ) . 85 Prognostic value of premature ventricular complexes during exercise stress testing in 56,000 individuals without known structural heart disease from UK biobank: is a single ectopic prognostic? . Heart . Conference: Cardiac rhythm management vol. 107 , a68 - a68 .

Young W, Warren H, Mook-Kanamori D, Ramirez J, van Duijvenboden S, Orini M, Tinker A, van Heemst D et al. ( 2021 ) . BS8 Genetically-determined serum calcium levels influence markers of ventricular repolarisation: a mendelian randomisation study . Heart . Conference: Basic science vol. 107 , a159 - a160 .

Chen J, Spracklen CN, Marenne G, Varshney A, Corbin LJ, Luan J, Willems SM, Wu Y et al. ( 2021 ) . The trans-ancestral genomic architecture of glycemic traits . Nature Genetics vol. 53 , ( 6 ) 840 - 860 .

Manandhar I, Alimadadi A, Aryal S, Munroe P, Joe B, Cheng X ( 2021 ) . Machine Learning of Gut Microbiome Composition for Diagnostic Classification of Inflammatory Bowel Diseases . The FASEB Journal vol. 35 , ( S1 )

Raisi-Estabragh Z, Mccracken C, Gkontra P, Jaggi A, Ardissino M, Cooper J, Biasiolli L, Aung N et al. ( 2021 ) . Higher consumption of red and processed meat is associated with adverse cardiovascular magnetic resonance morpho-functional phenotypes: A study of 19,408 UK Biobank participants . European Journal of Preventive Cardiology . vol. 28 ,

Moksnes MR, Røsjø H, Richmond A, Lyngbakken MN, Graham SE, Hansen AF, Wolford BN, Taliun SAG et al. ( 2021 ) . Genome-wide association study of cardiac troponin I in the general population . Human Molecular Genetics vol. 30 , ( 21 ) 2027 - 2039 .

Petersen S, Munroe P, Aung N, Raisi-Estabragh Z ( 2021 ) . Associations of Meat and Fish Consumption With Conventional and Radiomics Cardiovascular Magnetic Resonance Phenotypes in the UK Biobank . Frontiers of Cardiovascular Medicine

Rezaei MJ, Woodward JR, Ramírez J, Munroe P ( 2021 ) . A Novel Two-Stage Heart Arrhythmia Ensemble Classifier . Computers vol. 10 , ( 5 )

Young WJ, Warren HR, Mook-Kanamori DO, Ramírez J, van Duijvenboden S, Orini M, Tinker A, van Heemst D et al. ( 2021 ) . Genetically Determined Serum Calcium Levels and Markers of Ventricular Repolarization . Circulation Genomic and Precision Medicine vol. 14 , ( 3 )

Wang H, Noordam R, Cade BE, Schwander K, Winkler TW, Lee J, Sung YJ, Bentley AR et al. ( 2021 ) . Multi-ancestry genome-wide gene–sleep interactions identify novel loci for blood pressure . Molecular Psychiatry vol. 26 , ( 11 ) 6293 - 6304 .

Petersen S, Munroe P, Aung N ( 2021 ) . Prevalence of hypertrophic cardiomyopathy in the UK Biobank population . JAMA Cardiology

Petersen S ( 2021 ) . Women with diabetes are at increased relative risk of heart failure compared to men: Insights from UK Biobank . Frontiers in Cardiovascular Medicine

Warren H, Garofalidou T, Singh S, Melander O, Hiltunen T, Glorioso N, Cooper-Dehoff R, Dominiczak A et al. ( 2021 ) . GENOME-WIDE ASSOCIATION STUDY FOR PHARMACOGENETIC RESPONSE OF BLOOD PRESURE TO BETA BLOCKER AND CALCIUM CHANNEL BLOCKER DRUGS . Journal of Hypertension vol. 39 , ( Supplement 1 ) e258 - e259 .

Warren H, Traylor M, Garofalidou T, Ng FL, Gupta A, Sever P, Caulfield M, Munroe P ( 2021 ) . HYPERTENSIVE PATIENTS WITH GREATER GENETIC RISK RESPOND LESS EFFECTIVELY TO TREATMENT AND ARE MORE LIKELY TO BE TREATMENT RESISTANT . Journal of Hypertension vol. 39 , ( Supplement 1 )

Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B et al. ( 2021 ) . Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals . Nature Genetics vol. 53 , ( 5 ) 762 - 762 .

Sebastian S, Nobles M, Tsisanova E, Ludwig A, Munroe PB, Tinker A ( 2021 ) . The role of resistance to inhibitors of cholinesterase 8b in the control of heart rate . Physiological Genomics vol. 53 , ( 4 ) 150 - 159 .

Raisi-Estabragh Z, McCracken C, Cooper J, Fung K, Paiva J, Khanji M, Rauseo E, Biasiolli L et al. ( 2021 ) . Adverse cardiovascular magnetic resonance phenotypes are associated with greater likelihood of incident coronavirus disease 2019: Findings from the UK Biobank . Aging Clinical and Experimental Research

Mensah-Kane J, Schmidt AF, Hingorani AD, Finan C, Chen Y, van Duijvenboden S, Orini M, Lambiase PD et al. ( 2021 ) . No Clinically Relevant Effect of Heart Rate Increase and Heart Rate Recovery During Exercise on Cardiovascular Disease: A Mendelian Randomization Analysis . Frontiers in Genetics vol. 12 ,

Lagou V, Mägi R, Hottenga J-J, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D et al. ( 2021 ) . Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability . Nature Communications vol. 12 , ( 1 )

Manandhar I, Alimadadi A, Aryal S, Munroe PB, Joe B, Cheng X ( 2021 ) . Gut microbiome-based supervised machine learning for clinical diagnosis of inflammatory bowel diseases . Am J Physiol Gastrointest Liver Physiol

Lagou V, Mägi R, Hottenga J-J, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D et al. ( 2021 ) . Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability . Nature Communications vol. 12 , ( 1 )

Magavern EF, Warren HR, Ng FL, Cabrera CP, Munroe PB, Caulfield MJ ( 2021 ) . An Academic Clinician’s Road Map to Hypertension Genomics . Hypertension vol. 77 , ( 2 ) 284 - 295 .

Raisi-Estabragh Z, Biasiolli L, Cooper J, Aung N, Fung K, Paiva J, Sanghvi M, Thomson R et al. ( 2021 ) . ASSOCIATIONS BETWEEN BONE AND VASCULAR HEALTH IN THE UK BIOBANK . OSTEOPOROSIS INTERNATIONAL . vol. 32 , S41 - S41 .

Ramirez J, van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB ( 2021 ) . Prediction of Coronary Artery Disease using Traditional and Genetic Risk Scores for Cardiovascular Risk Factors . GENETIC EPIDEMIOLOGY . vol. 45 , 783 - 783 .

Young WJ, Srinivasan N, Tinker A, Munroe PB, Lambiase PD, Orini M ( 2020 ) . Comparisons of the Spatial QRS-T Angle With Intra-cardiac Markers of Depolarization and Repolarization . 2016 Computing in Cardiology Conference (CinC) . Conference: 2020 Computing in Cardiology Conference (CinC) vol. 00 , 1 - 4 .

van Duijvenboden S, Ramírez J, Young WJ, Tinker A, Munroe PB, Lambiase PD, Orini M ( 2020 ) . Evaluating the Impact of Physiological Variability in Genome-Wide Association Studies of Resting Heart Rate . 2016 Computing in Cardiology Conference (CinC) . Conference: 2020 Computing in Cardiology Conference (CinC) vol. 00 , 1 - 4 .

Aung N, Young WJ, van Duijvenboden S, Ramírez J, Petersen SE, Munroe PB ( 2020 ) . Genetic Architecture of Quantitative Cardiovascular Traits: Blood Pressure, ECG and Imaging Phenotypes . 2016 Computing in Cardiology Conference (CinC) . Conference: 2020 Computing in Cardiology Conference (CinC) vol. 00 , 1 - 4 .

Ramírez J, van Duijvenboden S, Tinker A, Lambiase PD, Munroe PB, Orini M ( 2020 ) . Sex Differences in the Morphology of RR-Matched T-waves . 2016 Computing in Cardiology Conference (CinC) . Conference: 2020 Computing in Cardiology Conference (CinC) vol. 00 , 1 - 4 .

Young WJ, Ramírez J, van Duijvenboden S, Tinker A, Lambiase PD, Munroe PB, Orini M ( 2020 ) . Will Genetic Data Significantly Change Cardiovascular Risk Prediction in Daily Practice? . 2016 Computing in Cardiology Conference (CinC) . Conference: 2020 Computing in Cardiology Conference (CinC) vol. 00 , 1 - 4 .

Petersen S, Raisi-Estabragh Z ( 2020 ) . REPEATABILITY OF CARDIAC MAGNETIC RESONANCE RADIOMICS: A MULTICENTRE MULTI-VENDOR TEST-RETEST STUDY . Frontiers in Cardiovascular Medicine

Raisi-Estabragh Z, Jaggi A, Aung N, Neubauer S, Piechnik S, Munroe PB, Harvey NC, Lekadir K et al. ( 2020 ) . Variation of cardiac magnetic resonance radiomics features by age and sex in healthy participants from the UK Biobank . European Heart Journal . vol. 41 ,

Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B et al. ( 2020 ) . Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals . Nature Genetics vol. 52 , ( 12 ) 1314 - 1332 .

Aung N, Sanghvi M, Piechnik SK, Naubauer S, Munroe P, Petersen S ( 2020 ) . The effect of lipids on the left ventricle: a Mendelian randomization study . JACC - Journal of the American College of Cardiology vol. 76 , ( 21 )

Aung N, Khanji MY, Munroe PB, Petersen SE ( 2020 ) . Causal Inference for Genetic Obesity, Cardiometabolic Profile and COVID-19 Susceptibility: A Mendelian Randomization Study . Frontiers in Genetics vol. 11 ,

Rezaei MJ, Woodward JR, Ramírez J, Munroe P ( 2020 ) . Data Augmentation for Heart Arrhythmia Classification . Conference: 2020 IEEE 32nd International Conference on Tools with Artificial Intelligence (ICTAI) vol. 00 , 929 - 934 .

Young WJ, van Duijvenboden S, Ramírez J, Jones A, Tinker A, Munroe PB, Lambiase PD, Orini M ( 2020 ) . A Method to Minimise the Impact of ECG Marker Inaccuracies on the Spatial QRS-T angle: Evaluation on 1,512 Manually Annotated ECGs . Biomedical Signal Processing and Control vol. 64 ,

García-González J, Ramírez J, Howard DM, Brennan CH, Munroe PB, Keers R ( 2020 ) . The effects of polygenic risk for psychiatric disorders and smoking behaviour on psychotic experiences in UK Biobank . Translational Psychiatry vol. 10 , ( 1 )

Raisi‐Estabragh Z, Biasiolli L, Cooper J, Aung N, Fung K, Paiva JM, Sanghvi MM, Thomson RJ et al. ( 2020 ) . Poor Bone Quality is Associated With Greater Arterial Stiffness: Insights From the UK Biobank . Journal of Bone and Mineral Research vol. 36 , ( 1 ) 90 - 99 .

Ramirez J, Van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Munroe PB, Orini M ( 2020 ) . Interaction between ECG and Genetic Markers of Coronary Artery Disease . Computing in Cardiology . Conference: CinC 2020 from: 13/09/2020 to: 16/09/2020 , vol. 2020-September ,

Patel V, Asatryan B, Siripanthong B, Munroe PB, Tiku-Owens A, Lopes LR, Khanji MY, Protonotarios A et al. ( 2020 ) . State of the Art Review on Genetics and Precision Medicine in Arrhythmogenic Cardiomyopathy . International Journal of Molecular Sciences vol. 21 , ( 18 )

Alimadadi A, Manandhar I, Aryal S, Munroe PB, Joe B, Cheng X ( 2020 ) . Machine learning-based classification and diagnosis of clinical cardiomyopathies . Physiol Genomics vol. 52 , ( 9 ) 391 - 400 .

Cheng X, Alimadadi A, Manandhar I, Aryal S, Munroe PB, Joe B ( 2020 ) . Abstract P051: Application Of Artificial Intelligence In Transcriptome-based Diagnosis Of Cardiomyopathies . Hypertension vol. 76 , ( Suppl_1 )

Weng LC, Hall AW, Choi SH, Jurgens SJ, Haessler J, Bihlmeyer NA, Grarup N, Lin H et al. ( 2020 ) . Genetic determinants of electrocardiographic P-wave duration and relation to atrial fibrillation . Circulation: Genomic and Precision Medicine389 - 395 .

Raisi-Estabragh Z, McCracken C, Bethell MS, Cooper J, Cooper C, Caulfield MJ, Munroe PB, Harvey NC et al. ( 2020 ) . Greater risk of severe COVID-19 in Black, Asian and Minority Ethnic populations is not explained by cardiometabolic, socioeconomic or behavioural factors, or by 25(OH)-vitamin D status: study of 1326 cases from the UK Biobank . Journal of Public Health vol. 42 , ( 3 ) 451 - 460 .

van Duijvenboden S, Ramírez J, Young WJ, Mifsud B, Orini M, Tinker A, Munroe PB, Lambiase PD ( 2020 ) . Genetic Basis and Prognostic Value of Exercise QT Dynamics . Circulation Genomic and Precision Medicine vol. 13 , ( 4 ) e002774 - e002774 .

Raisi-Estabragh Z, McCracken C, Bethell MS, Cooper J, Cooper C, Caulfield MJ, Munroe PB, Harvey NC et al. ( 2020 ) . Greater risk of severe COVID-19 in non-White ethnicities is not explained by cardiometabolic, socioeconomic, or behavioural factors, or by 25(OH)-vitamin D status: study of 1,326 cases from the UK Biobank .

Raisi-Estabragh Z, Cooper J, Judge R, Khanji M, Munroe P, Cooper C, Harvey NC, Petersen S ( 2020 ) . Age, sex and disease-specific associations between resting heart rate and cardiovascular mortality in the UK BIOBANK . PLoS One

Raisi-Estabragh Z, Kenawy AAM, Aung N, Cooper J, Munroe PB, Harvey NC, Petersen SE, Khanji MY ( 2020 ) . Variation in left ventricular cardiac magnetic resonance normal reference ranges: systematic review and meta-analysis . European Heart Journal - Cardiovascular Imaging vol. 22 , ( 5 ) 494 - 504 .

Ntalla I, Weng L-C, Cartwright JH, Hall AW, Sveinbjornsson G, Tucker NR, Choi SH, Chaffin MD et al. ( 2020 ) . Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction . Nature Communications vol. 11 , ( 1 )

Ramírez J, van Duijvenboden S, Young WJ, Orini M, Lambiase PD, Munroe PB, Tinker A ( 2020 ) . Common Genetic Variants Modulate the Electrocardiographic Tpeak-to-Tend Interval . American Journal of Human Genetics vol. 106 , ( 6 ) 764 - 778 .

de las Fuentes L, Sung YJ, Noordam R, Winkler T, Feitosa MF, Schwander K, Bentley AR, Brown MR et al. ( 2020 ) . Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci . Molecular Psychiatry

Nicholls HL, John CR, Watson DS, Munroe PB, Barnes MR, Cabrera CP ( 2020 ) . Reaching the End-Game for GWAS: Machine Learning Approaches for the Prioritization of Complex Disease Loci . Frontiers in Genetics vol. 11 ,

Alimadadi A, Aryal S, Manandhar I, Munroe PB, Joe B, Cheng X ( 2020 ) . Artificial intelligence and machine learning to fight COVID-19 . Physiological Genomics vol. 52 , ( 4 ) 200 - 202 .

Fung K, Biasiolli L, Hann E, Ramirez J, Lukaschuk E, Aung N, Paiva J, Werys K et al. ( 2019 ) . 3.2 First Genome-Wide Association Study of Cardiovascular Magnetic Resonance Derived Aortic Distensibility Reveals 7 Loci . Artery Research . vol. 25 , s21 - s22 .

Aung N, Doimo S, Ricci F, Sanghvi MM, Pedrosa C, Woodbridge SP, Al-Balah A, Zemrak F et al. ( 2020 ) . Prognostic Significance of Left Ventricular Noncompaction . Circulation Cardiovascular Imaging vol. 13 , ( 1 ) e009712 - e009712 .

Alimadadi A, Munroe PB, Joe B, Cheng X ( 2020 ) . Meta-analysis of dilated cardiomyopathy using cardiac rna-seq transcriptomic datasets . Genes vol. 11 , ( 1 )

Garofalidou T, Munroe PB ( 2020 ) . Chapter 11 Molecular pathophysiology of systemic hypertension . Clinical Molecular Medicine , Elsevier

Cabrera CP, Pazoki R, Giri A, Hellwege JN, Evangelou E, Ramirez J, Wain LV, Tzoulaki I et al. ( 2020 ) . Multi-trait genome-wide association analysis of blood pressure identifies 45 additional loci . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 28 , 105 - 105 .

García-González J, Ramírez J, Howard DM, Brennan CH, Munroe PB, Keers R ( 2019 ) . The effects of polygenic risk for psychiatric disorders and smoking behaviour on psychotic experiences in UK Biobank .

Noordam R, Bos MM, Wang H, Winkler TW, Bentley AR, Kilpeläinen TO, de Vries PS, Sung YJ et al. ( 2019 ) . Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration . Nature Communications vol. 10 , ( 1 )

Clark DW, Okada Y, Moore KHS, Mason D, Pirastu N, Gandin I, Mattsson H, Barnes CLK et al. ( 2019 ) . Associations of autozygosity with a broad range of human phenotypes . Nature Communications vol. 10 , ( 1 ) 4957 - 4957 .

Timasheva Y, Zudina L, Balkhiyarova Z, Kaakinen M, Munroe P, Prokopenko I ( 2019 ) . P4411Analysis of cardiometabolic traits highlights shared biological pathways . European Heart Journal vol. 40 , ( Supplement_1 )

Teumer A, Trenkwalder T, Kessler T, Jamshidi Y, van den Berg ME, Kaess B, Nelson CP, Bastiaenen R et al. ( 2019 ) . KCND3 potassium channel gene variant confers susceptibility to electrocardiographic early repolarization pattern . JCI insight

Ramírez J, van Duijvenboden S, Aung N, Laguna P, Pueyo E, Tinker A, Lambiase PD, Orini M et al. ( 2019 ) . Cardiovascular Predictive Value and Genetic Basis of Ventricular Repolarization Dynamics . Circulation: Arrhythmia and Electrophysiology vol. 12 , ( 10 ) e007549 - e007549 .

Munroe PB, Ramírez J, van Duijvenboden S ( 2019 ) . Resting Heart Rate and Type 2 Diabetes A Complex Relationship in Need of Greater Understanding ∗ . Journal of the American College of Cardiology vol. 74 , ( 17 ) 2175 - 2177 .

Petersen S, Munroe P, Aung N, Fung K, Vargas J, Yang C, Cabrera CP, Warren H et al. ( 2019 ) . Genome-wide analysis of left ventricular image-derived phenotypes identifies fourteen loci associated with cardiac morphogenesis and heart failure development . Circulation

Noordam R, Young WJ, Munroe PB ( 2019 ) . Electrolytes and electrophysiology: What's next? . Aging vol. 11 , ( 18 ) 7329 - 7330 .

Iniesta R, Campbell D, Venturini C, Faconti L, Singh S, Irvin MR, Cooper-DeHoff RM, Johnson JA et al. ( 2019 ) . Gene Variants at Loci Related to Blood Pressure Account for Variation in Response to Antihypertensive Drugs Between Black and White Individuals . Hypertension vol. 74 , ( 3 ) 614 - 622 .

Singh S, Warren HR, Hiltunen TP, McDonough CW, El Rouby N, Salvi E, Wang Z, Garofalidou T et al. ( 2019 ) . Genome-Wide Meta-Analysis of Blood Pressure Response to β<inf>1</inf>-Blockers: Results From ICAPS (International Consortium of Antihypertensive Pharmacogenomics Studies) . Journal of the American Heart Association vol. 8 , ( 16 )

Cartwright JH, Aziz Q, Harmer SC, Thayyil S, Tinker A, Munroe PB ( 2019 ) . Genetic variants in TRPM7 associated with unexplained stillbirth modify ion channel function . Human Molecular Genetics vol. 29 , ( 11 ) 1797 - 1807 .

Cabrera CP, Ng F, Nicholls HL, Gupta A, Barnes MR, Munroe PB, Caulfield MJ ( 2019 ) . Over 1000 genetic loci influencing blood pressure with multiple systems and tissues implicated . Human Molecular Genetics vol. 28 , ( R2 ) R151 - R161 .

Thomas AM, Cabrera CP, Finlay M, Lall K, Nobles M, Schilling RJ, Wood K, Mein CA et al. ( 2019 ) . Differentially expressed genes for atrial fibrillation identified by RNA sequencing from paired human left and right atrial appendages . Physiol Genomics vol. 51 , ( 8 ) 323 - 332 .

Timasheva Y, Zudina L, Balkhiyarova Z, Kaakinen M, Munroe P, Prokopenko I ( 2019 ) . GENETICS OF HYPERTENSION ENDOPHENOTYPES AND METABOLIC TRAITS HIGHLIGHTS SHARED BIOLOGICAL PATHWAYS . Journal of Hypertension . vol. 37 ,

Fung K, Ramírez J, Warren HR, Aung N, Lee AM, Tzanis E, Petersen SE, Munroe PB ( 2019 ) . Genome-wide association study identifies loci for arterial stiffness index in 127,121 UK Biobank participants . Scientific Reports vol. 9 , ( 1 )

Aung N, Vargas JD, Manichaikul AW, Yang C, Cabrera CP, Warren HR, Fung K, Tzanis E et al. ( 2019 ) . 199Genetic architecture of left ventricular phenotypes derived from 17,000 CMR studies in the UK Biobank population imaging cohort . European Heart Journal - Cardiovascular Imaging . vol. 20 ,

Aung N, Vargas JD, Manichaikul AW, Yang CP, Cabrera CP, Warren HR, Fung K, Tzanis E et al. ( 2019 ) . P463Heritability and genotypic correlation of CMR-derived LV phenotypes in the UK Biobank population imaging study . European Heart Journal - Cardiovascular Imaging . vol. 20 ,

Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T et al. ( 2019 ) . Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity . Nature Genetics vol. 51 , ( 7 ) 1191 - 1192 .

Noordam R, Young WJ, Salman R, Kanters JK, van den Berg ME, van Heemst D, Lin HJ, Barreto SM et al. ( 2019 ) . Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals . Journal of the American College of Cardiology vol. 73 , ( 24 ) 3118 - 3131 .

Ramirez J, van Duijvenboden S, Tinker A, Lambiase P, Orini M, Munroe PB ( 2019 ) . 21 The cardiovascular predictive value and genetic basis of T-wave morphology . Heart . Conference: Cardiac rhythm management vol. 105 ,

van Duijvenboden S, Ramirez J, Orini M, Tinker A, Munroe PB, Lambiase P ( 2019 ) . 22 Cardiac repolarization during exercise reveals independent prognostic information for cardiovascular risk prediction . Heart . Conference: Cardiac Rhythm Management vol. 105 ,

Fung K, Biasiolli L, Hann E, Aung N, Paiva J, Lukaschuk E, Sanghvi M, Carapella V et al. ( 2019 ) . 9 Effect of coffee consumption on arterial stiffness from UK biobank imaging study . Heart . Conference: Imaging vol. 105 ,

Sung YJ, de las Fuentes L, Winkler TW, Chasman DI, Bentley AR, Kraja AT, Ntalla I, Warren HR et al. ( 2019 ) . A multi-ancestry genome-wide study incorporating gene–smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure . Human Molecular Genetics vol. 28 , ( 15 ) 2615 - 2633 .

Bentley AR, Sung YJ, Brown MR, Winkler TW, Kraja AT, Ntalla I, Schwander K, Chasman DI et al. ( 2019 ) . Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids . Nature Genetics vol. 51 , ( 4 ) 636 - 648 .

Justice AE, Karaderi T, Highland HM, Young KL, Graff M, Lu Y, Turcot V, Auer PL et al. ( 2019 ) . Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution . Nature Genetics vol. 51 , ( 3 ) 452 - 469 .

de Vries PS, Brown MR, Bentley AR, Sung YJ, Winkler TW, Ntalla I, Schwander K, Kraja AT et al. ( 2019 ) . Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions . American Journal of Epidemiology vol. 188 , ( 6 ) 1033 - 1054 .

van Setten J, Verweij N, Mbarek H, Niemeijer MN, Trompet S, Arking DE, Brody JA, Gandin I et al. ( 2019 ) . Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits . European Journal of Human Genetics vol. 27 , ( 6 ) 952 - 962 .

Kilpeläinen TO, Bentley AR, Noordam R, Sung YJ, Schwander K, Winkler TW, Jakupović H, Chasman DI et al. ( 2019 ) . Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity . Nature Communications vol. 10 , ( 1 )

Erzurumluoglu AM, Liu M, Jackson VE, Barnes DR, Datta G, Melbourne CA, Young R, Batini C et al. ( 2019 ) . Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci . Molecular Psychiatry vol. 25 , ( 10 ) 2392 - 2409 .

Timasheva Y, Zudina L, Balkhiyarova Z, Kaakinen M, Munroe P, Prokopenko I ( 2019 ) . Analysis of cardiometabolic traits highlights shared biological pathways . EUROPEAN HEART JOURNAL . vol. 40 , 2643 - 2643 .

McDonough CW, Warren HR, Jack JR, Motsinger-Reif AA, El Rouby NM, Gong Y, Mychaleckyj JC, Benavente OR et al. ( 2019 ) . DRUG-SNP INTERACTIONS AND CARDIOVASCULAR OUTCOMES: A GENOME-WIDE META-ANALYSIS IN THE INTERNATIONAL CONSORTIUM FOR ANTIHYPERTENSIVE PHARMACOGENOMICS STUDIES . CLINICAL PHARMACOLOGY & THERAPEUTICS . vol. 105 , S105 - S106 .

Singh S, Warren HR, Hiltunen TP, Salvi E, El Rouby N, Garofalidou T, Fyhrquist F, Kontula KK et al. ( 2019 ) . GENOME WIDE META-ANALYSIS OF BLOOD PRESSURE RESPONSE TO B-BLOCKERS: RESULTS FROM INTERNATIONAL CONSORTIUM OF ANTIHYPERTENSIVE PHARMACOGENOMICS STUDIES . CLINICAL PHARMACOLOGY & THERAPEUTICS . vol. 105 , S16 - S16 .

Singh S, Warren HR, Hiltunen TP, Salvi E, El Rouby N, Garofalidou T, Fyhrquist F, Kontula KK et al. ( 2019 ) . GENOME WIDE META-ANALYSIS OF BLOOD PRESSURE RESPONSE TO B-BLOCKERS: RESULTS FROM INTERNATIONAL CONSORTIUNI OF ANTIHYPERTENSIVE PHARMACOGENOMICS STUDIES . CLINICAL PHARMACOLOGY & THERAPEUTICS . vol. 105 , S27 - S27 .

Aung N, Vargas JD, Manichaikul AW, Yang C, Cabrera CP, Warren HR, Fung K, Tzanis E et al. ( 2019 ) . Genetic architecture of left ventricular phenotypes derived from 17,000 CMR studies in the UK Biobank population imaging cohort . EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING . vol. 20 , 155 - 156 .

Aung N, Vargas JD, Manichaikul AW, Yang CP, Cabrera CP, Warren HR, Fung K, Tzanis E et al. ( 2019 ) . Heritability and genotypic correlation of CMR-derived LV phenotypes in the UK Biobank population imaging study . EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING . vol. 20 , 377 - 378 .

Ramirez J, van Duijvenboden S, Ntalla I, Mifsud B, Warren HR, Tzanis E, Orini M, Tinker A et al. ( 2019 ) . Identification of novel loci for heart rate response to exercise and recovery . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 27 , 135 - 135 .

Ntalla I, Weng L, Warren HR, Jamshidi Y, Munroe PB, Lubitz SA ( 2019 ) . Multi-ancestry genome-wide association meta-analysis of 293,000 individuals identifies 217 regions for the electrocardiographic PR interval . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 27 , 158 - 159 .

Giri A, Hellwege JN, Keaton JM, Park J, Qiu C, Warren HR, Torstenson ES, Kovesdy CP et al. ( 2018 ) . Trans-ethnic association study of blood pressure determinants in over 750,000 individuals . Nature Genetics vol. 51 , ( 1 ) 51 - 62 .

Brazel DM, Jiang Y, Hughey JM, Turcot V, Zhan X, Gong J, Batini C, Weissenkampen JD et al. ( 2018 ) . Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use . Biological Psychiatry

Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N et al. ( 2018 ) . Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits . Nat Genet vol. 50 , ( 12 ) 1755 - 1755 .

Ramírez J, van Duijvenboden S, Orini M, Tinker A, Munroe PB, Lambiase PD ( 2018 ) . 23T-wave morphology restitution predicts arrhythmic risk in the UK biobank cohort . EP Europace vol. 20 , ( suppl_4 ) iv10 - iv11 .

van Duijvenboden S, Ramírez J, Orini M, Tinker A, Munroe PB, Lambiase PD ( 2018 ) . 2QT interval and exercise qt dynamics from 58,852 individuals in UK biobank predict ventricular arrhythmias and heart failure . EP Europace vol. 20 , ( suppl_4 ) iv1 - iv1 .

Bastiaenen R, Nolte IM, Munroe PB, Riese H, Nelson C, O'Connor H, Gang Y, Warren HR et al. ( 2018 ) . The narrow-sense and common single nucleotide polymorphism heritability of early repolarization . International Journal of Cardiology vol. 279 , 135 - 140 .

Pärn K, Pirinen M, Kals M, Mägi R, Salomaa V, Boehnke M, Hall I, Stitziel N et al. ( 2018 ) . Differences in the commonly used genotype imputation algorithms and their imputation accuracy estimates . Conference: 2018 IEEE 14th International Conference on e-Science (e-Science)293 - 294 .

Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N et al. ( 2018 ) . Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits . Nature Genetics vol. 50 , ( 10 ) 1412 - 1425 .

Ramirez J, Van Duijvenboden S, Laguna P, Pueyo E, Tinker A, Lambiase PD, Munroe PB, Orini M ( 2018 ) . Assessing a Warping Methodology for the Identification of Increased Cardiovascular Risk Based on the HR Profile Morphology . Computing in Cardiology . Conference: Computing in Cardiology ( Maastricht, The Netherlands ) from: 23/09/2018 to: 26/09/2018 , vol. 2018-September ,

PETERSEN SE, AUNG N, SANGHVI M, ZEMRAK F, LEE A, COOPER J, PAIVA J, Thomson R et al. ( 2018 ) . Association between ambient air pollution and cardiac morpho-functional phenotypes: Insights from the UK Biobank population imaging study . Circulation

van Setten J, Brody JA, Jamshidi Y, Swenson BR, Butler AM, Campbell H, Del Greco FM, Evans DS et al. ( 2018 ) . PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity . Nature Communications vol. 9 , ( 1 )

Prins BP, Mead TJ, Brody JA, Sveinbjornsson G, Ntalla I, Bihlmeyer NA, van den Berg M, Bork-Jensen J et al. ( 2018 ) . Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6 . Genome Biology vol. 19 , ( 1 )

Consortium TB, Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V et al. ( 2018 ) . Analysis of shared heritability in common disorders of the brain . Science vol. 360 , ( 6395 )

Ruderfer DM, Ripke S, McQuillin A, Boocock J, Stahl EA, Pavlides JMW, Mullins N, Charney AW et al. ( 2018 ) . Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes . Cell

Feitosa MF, Kraja AT, Chasman DI, Sung YJ, Winkler TW, Ntalla I, Guo X, Franceschini N et al. ( 2018 ) . Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries . PLoS One vol. 13 , ( 6 ) e0198166 - e0198166 .

Ramírez J, Duijvenboden SV, Ntalla I, Mifsud B, Warren HR, Tzanis E, Orini M, Tinker A et al. ( 2018 ) . Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system . Nature Communications vol. 9 , ( 1 )

Lin H, van Setten J, Smith AV, Bihlmeyer NA, Warren HR, Brody JA, Radmanesh F, Hall L et al. ( 2018 ) . Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval . Circulation Genomic and Precision Medicine vol. 11 , ( 5 )

Smith AJP, Deloukas P, Munroe PB ( 2018 ) . Emerging applications of genome-editing technology to examine functionality of GWAS-associated variants for complex traits . Physiol Genomics

Sung YJ, Winkler TW, de las Fuentes L, Bentley AR, Brown MR, Kraja AT, Schwander K, Ntalla I et al. ( 2018 ) . A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure . American Journal of Human Genetics vol. 102 , ( 3 ) 375 - 400 .

Orini M, Tinker A, Munroe PB, Lambiase PD ( 2018 ) . Correction: Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort . PLoS One vol. 13 , ( 2 ) e0193039 - e0193039 .

Munroe PB, Jahangir SNS, Caulfield MJ ( 2018 ) . Genetics and Genomics of Systemic Hypertension . Cardiovascular Genetics and Genomics , Springer Nature

Bihlmeyer NA, Brody JA, Smith AV, Warren HR, Lin H, Isaacs A, Liu C-T, Marten J et al. ( 2018 ) . ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals . Circulation Genomic and Precision Medicine vol. 11 , ( 1 ) e001758 - e001758 .

Munroe PB, Addison S, Abrams DJ, Sebire NJ, Cartwright J, Donaldson I, Cohen MM, Mein C et al. ( 2018 ) . Postmortem Genetic Testing for Cardiac Ion Channelopathies in Stillbirths . Circulation Genomic and Precision Medicine vol. 11 , ( 1 )

Munroe PB, Warren HR ( 2018 ) . Chapter 5 Hypertension . Genomic and Precision Medicine , Elsevier

Munroe PB, Warren HR ( 2018 ) . Hypertension . Genomic and Precision Medicine: Cardiovascular Disease: Third Edition ,

Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T et al. ( 2017 ) . Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity . Nature Genetics vol. 50 , ( 1 ) 26 - 41 .

McCarthy NS, Vangjeli C, Surendran P, Treumann A, Rooney C, Ho E, Sever P, Thom S et al. ( 2017 ) . Genetic variants in PPARGC1B and CNTN4 are associated with thromboxane A2 formation and with cardiovascular event free survival in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) . Atherosclerosis vol. 269 , 42 - 49 .

Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C et al. ( 2017 ) . Exome-wide association study of plasma lipids in >300,000 individuals . Nature Genetics vol. 49 , ( 12 ) 1758 - 1766 .

Ren M, Ng FL, Warren HR, Witkowska K, Baron M, Jia Z, Cabrera C, Zhang R et al. ( 2017 ) . The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle . Human Molecular Genetics vol. 27 , ( 1 ) 199 - 210 .

Warren H, Sun F, Stewart J, Broer L, Trompet S, Clarke H, Sitlani C, Noordam R et al. ( 2017 ) . Large-scale genome-wide pharmacogenetic meta-analysis of blood pressure response to antihypertensive drugs . vol. 31 , is. 10 , pp. 659 - 659 .

Kraja AT, Cook JP, Warren HR, Surendran P, Liu C, Evangelou E, Manning AK, Grarup N et al. ( 2017 ) . New Blood Pressure–Associated Loci Identified in Meta-Analyses of 475 000 Individuals . Circulation Genomic and Precision Medicine vol. 10 , ( 5 )

Little L, Kraja AT, Cook JP, Warren HR, Newton-Cheh C, Munroe PB, Howson JMM, BP CE et al. ( 2017 ) . New blood pressure associated loci identified in meta-analyses of 475,000 individuals using the Exome Chip . vol. 31 , is. 10 , pp. 665 - 666 .

Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, Ntalla I, Surendran P et al. ( 2017 ) . Corrigendum: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk . Nat Genet vol. 49 , ( 10 ) 1558 - 1558 .

Orini M, Tinker A, Munroe PB, Lambiase PD ( 2017 ) . Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort . PLoS One vol. 12 , ( 9 ) e0183732 - e0183732 .

Kraja AT, Feitosa MF, Chasman D, Sung YJ, Winkler TW, Ntalla I, Aschard H, Rice K et al. ( 2017 ) . Abstract P530: Pleiotropic Effects on Blood Pressure Traits Using Genome-wide Analysis of Gene-alcohol Interactions . Hypertension vol. 70 , ( suppl_1 )

Wain LV, Vaez A, Jansen R, Joehanes R, van der Most PJ, Erzurumluoglu AM, O'Reilly PF, Cabrera CP et al. ( 2017 ) . Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney . Hypertension vol. 70 , ( 3 ) e4 - e19 .

Munroe PB, Tinker A ( 2017 ) . Heritability of resting heart rate and association with mortality in middle-aged and elderly twins . Heart vol. 104 , ( 1 ) 6 - 7 .

Rao DC, Sung YJ, Winkler TW, Schwander K, Borecki I, Cupples LA, Gauderman WJ, Rice K et al. ( 2017 ) . Multiancestry Study of Gene–Lifestyle Interactions for Cardiovascular Traits in 610 475 Individuals From 124 Cohorts . Circulation Genomic and Precision Medicine vol. 10 , ( 3 )

Wu Y-T, Luben R, Wareham N, Griffin S, Jones AP ( 2017 ) . Weather, day length and physical activity in older adults: Cross-sectional results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Norfolk Cohort . PLoS One vol. 12 , ( 5 ) e0177767 - e0177767 .

Song C, Burgess S, Eicher JD, O'Donnell CJ, Johnson AD, Huang J, Sabater-Lleal M, Asselbergs FW et al. ( 2017 ) . Causal effect of plasminogen activator inhibitor type 1 on coronary heart disease . Journal of the American Heart Association vol. 6 , ( 6 )

Dale CE, Fatemifar G, Palmer TM, White J, Prieto-Merino D, Zabaneh D, Engmann JEL, Shah T et al. ( 2017 ) . Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus . Circulation vol. 135 , ( 24 ) 2373 - 2388 .

Cartwright J, Aziz Q, Harmer S, Tinker A, Munroe P ( 2017 ) . Functional Studies of TRPM7-a Candidate Gene for Stillbirth? . FASEB JOURNAL . Conference: EB vol. 31 ,

Justice AE, Winkler TW, Feitosa MF, Graff M, Fisher VA, Young K, Barata L, Deng X et al. ( 2017 ) . Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits . Nat Commun vol. 8 , 14977 - 14977 .

MUNROE PB, Caulfield M, Stirrups K, van den Berg M, Warren H, Cabrera CP ( 2017 ) . Discovery of novel heart rate-associated loci using the exome chip . Human Molecular Genetics

Munroe PB, Warren HR ( 2017 ) . Hypertension . Genomic and Precision Medicine: Primary Care: Third Edition ,

McLaughlin RL, Schijven D, Van Rheenen W, Van Eijk KR, O'Brien M, Kahn RS, Ophoff RA, Goris A et al. ( 2017 ) . Genetic correlation between amyotrophic lateral sclerosis and schizophrenia . Nature Communications vol. 8 ,

Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, Ntalla I, Surendran P et al. ( 2017 ) . Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk . Nat Genet vol. 49 , ( 3 ) 403 - 415 .

Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, Fine RS, Lu Y et al. ( 2017 ) . Rare and low-frequency coding variants alter human adult height . Nature vol. 542 , ( 7640 ) 186 - 190 .

Munroe PB, Warren HR ( 2017 ) . Chapter 7 Hypertension . Genomic and Precision Medicine , Elsevier

Kraja AT, Feitosa MF, Chasman D, Sung YJ, Winkler TW, Ntalla I, Aschard H, Rice K et al. ( 2017 ) . Pleiotropic Effects on Blood Pressure Traits Using Genome-wide Analysis of Gene-alcohol Interactions . HYPERTENSION . vol. 70 ,

Noordam R, Sitlani CM, Avery CL, Stewart JD, Gogarten SM, Wiggins KL, Trompet S, Warren HR et al. ( 2016 ) . A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium . J Med Genet

Yaghootkar H, Bancks MP, Jones SE, McDaid A, Beaumont R, Donnelly L, Wood AR, Campbell A et al. ( 2016 ) . Quantifying the extent to which index event biases influence large genetic association studies . Hum Mol Genet

Wang Y, Wu Z, Luo H, Peng J, Raelson J, Ehret GB, Munroe PB, Stoyanova E et al. ( 2016 ) . The role of GRIP1 and ephrin B3 in blood pressure control and vascular smooth muscle cell contractility . Sci Rep vol. 6 , 38976 - 38976 .

Gregson JM, Freitag DF, Surendran P, Stitziel NO, Chowdhury R, Burgess S, Kaptoge S, Gao P et al. ( 2016 ) . Genetic invalidation of Lp-PLA2 as a therapeutic target: Large-scale study of five functional Lp-PLA2-lowering alleles . Eur J Prev Cardiol

Hayat SA, Luben R, Dalzell N, Moore S, Anuj S, Matthews FE, Wareham N, Brayne C et al. ( 2016 ) . Cross Sectional Associations between Socio-Demographic Factors and Cognitive Performance in an Older British Population: The European Investigation of Cancer in Norfolk (EPIC-Norfolk) Study . PLoS One vol. 11 , ( 12 ) Article 0166779 , e0166779 - e0166779 .

Eppinga RN, Hagemeijer Y, Burgess S, Hinds DA, Stefansson K, Gudbjartsson DF, van Veldhuisen DJ, Munroe PB et al. ( 2016 ) . Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality . Nat Genet vol. 48 , ( 12 ) 1557 - 1563 .

Ried JS, Jeff M J, Chu AY, Bragg-Gresham JL, van Dongen J, Huffman JE, Ahluwalia TS, Cadby G et al. ( 2016 ) . A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape . Nature Communications vol. 7 , 13357 - 13357 .

Marshall CR, Howrigan DP, Merico D, Thiruvahindrapuram B, Wu W, Greer DS, Antaki D, Shetty A et al. ( 2016 ) . Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects . Nature Genetics vol. 49 , ( 1 ) 27 - 35 .

Warren HR, van den Berg ME, van der Harst P, Verweij N, Eijgelsheim M, Stricker BH, Munroe PB, Grp CHARGECEKGW ( 2016 ) . Discovery of Novel Loci Associated with Heart Rate from Exome Chip Analysis . GENETIC EPIDEMIOLOGY . Conference: International Genetic Epidemiology Society vol. 40 , 670 - 670 .

Jepson RE, Warren HR, Syme HM, Elliott J, Munroe PB ( 2016 ) . Uromodulin gene variants and their association with renal function and blood pressure in cats: a pilot study . J Small Anim Pract vol. 57 , ( 11 ) 580 - 588 .

Barban N, Jansen R, de Vlaming R, Vaez A, Mandemakers JJ, Tropf FC, Shen X, Wilson JF et al. ( 2016 ) . Genome-wide analysis identifies 12 loci influencing human reproductive behavior . Nature Genetics vol. 48 , ( 12 ) 1462 - 1472 .

Johnson EC, Bjelland DW, Howrigan DP, Abdellaoui A, Breen G, Borglum A, Cichon S, Degenhardt F et al. ( 2016 ) . No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study . PLoS Genet vol. 12 , ( 10 ) e1006343 - e1006343 .

Julian C, Lentjes MAH, Huybrechts I, Luben R, Wareham N, Moreno LA, Khaw K-T ( 2016 ) . Fracture Risk in Relation to Serum 25-Hydroxyvitamin D and Physical Activity: Results from the EPIC-Norfolk Cohort Study . PLoS One vol. 11 , ( 10 ) e0164160 - e0164160 .

Warren HR, Surendran P, Manning AK, van den Berg ME, van der Harst P, Verweij N, Eijgelsheim M, Stricker BHC et al. ( 2016 ) . Novel loci discovery for blood pressure and heart rate using the Exome chip . JOURNAL OF HUMAN HYPERTENSION vol. 30 , ( 10 ) 653 - 653 .

van der Harst P, van Setten J, Verweij N, Vogler G, Franke L, Maurano MT, Wang X, Mateo Leach I et al. ( 2016 ) . 52 Genetic Loci Influencing Myocardial Mass . J Am Coll Cardiol vol. 68 , ( 13 ) 1435 - 1448 .

MUNROE PB ( 2016 ) . Fifty-two genetic loci influencing myocardial mass . Journal of the American College of Cardiology

MUNROE PB ( 2016 ) . Trans-ancestry meta-analyses identify novel rare and common variants associated with blood pressure and hypertension . Nature Genetics

MUNROE PB ( 2016 ) . The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals . Nature Genetics

Postmus I, Warren HR, Trompet S, Arsenault BJ, Avery CL, Bis JC, Chasman DI, de Keyser CE et al. ( 2016 ) . Meta-analysis of genome-wide association studies of HDL cholesterol response to statins . Journal of Medical Genetics

Yuyun MF, Khaw K-T, Luben R, Welch A, Bingham S, Day NE, Wareham NJ ( 2016 ) . Microalbuminuria, cardiovascular risk factors and cardiovascular morbidity in a British population: The EPIC-Norfolk Population-based Study . European Journal of Preventive Cardiology vol. 11 , ( 3 ) 207 - 213 .

Boekholdt SM, Sandhu MS, Day NE, Luben R, Bingham SA, Peters RJ, Wareham NJ, Khaw K-T ( 2016 ) . Physical activity, C-reactive protein levels and the risk of future coronary artery disease in apparently healthy men and women: the EPIC–Norfolk prospective population study . European Journal of Preventive Cardiology vol. 13 , ( 6 ) 970 - 976 .

Pinnock C, Yip JLY, Khawaja AP, Luben R, Hayat S, Broadway DC, Foster PJ, Khaw K-T et al. ( 2016 ) . Topical Beta-Blockers and Cardiovascular Mortality: Systematic Review and Meta-Analysis with Data from the EPIC-Norfolk Cohort Study . Ophthalmic Epidemiol vol. 23 , ( 5 ) 277 - 284 .

Basu N, Yang X, Luben RN, Whibley D, Macfarlane GJ, Wareham NJ, Khaw K-T, Myint PK ( 2016 ) . Fatigue is associated with excess mortality in the general population: results from the EPIC-Norfolk study . BMC Med vol. 14 , ( 1 ) 122 - 122 .

van der Laan SW, Fall T, Soumaré A, Teumer A, Sedaghat S, Baumert J, Zabaneh D, van Setten J et al. ( 2016 ) . Cystatin C and Cardiovascular Disease A Mendelian Randomization Study . Journal of the American College of Cardiology vol. 68 , ( 9 ) 934 - 945 .

Guo Y, Warren Andersen S, Shu X-O, Michailidou K, Bolla MK, Wang Q, Garcia-Closas M, Milne RL et al. ( 2016 ) . Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent . PLoS Med vol. 13 , ( 8 ) e1002105 - e1002105 .

Kanoni S, Masca NGD, Stirrups KE, Varga TV, Warren HR, Scott RA, Southam L, Zhang W et al. ( 2016 ) . Analysis with the exome array identifies multiple new independent variants in lipid loci . Human Molecular Genetics vol. 25 , ( 18 ) ddw227 - ddw227 .

Opstelten JL, Beelen RMJ, Leenders M, Hoek G, Brunekreef B, van Schaik FDM, Siersema PD, Eriksen KT et al. ( 2016 ) . Exposure to Ambient Air Pollution and the Risk of Inflammatory Bowel Disease: A European Nested Case-Control Study . Dig Dis Sci vol. 61 , ( 10 ) 2963 - 2971 .

Leng Y, Wainwright NWJ, Cappuccio FP, Surtees PG, Hayat S, Luben R, Brayne C, Khaw K-T ( 2016 ) . Daytime napping and increased risk of incident respiratory diseases: symptom, marker, or risk factor? . Sleep Med vol. 23 , 12 - 15 .

Leng Y, Cappuccio FP, Surtees PG, Luben R, Brayne C, Khaw K-T ( 2016 ) . Daytime napping, sleep duration and increased 8-year risk of type 2 diabetes in a British population . Nutrition Metabolism and Cardiovascular Diseases vol. 26 , ( 11 ) 996 - 1003 .

Prins BP, Abbasi A, Wong A, Vaez A, Nolte I, Franceschini N, Stuart PE, Guterriez Achury J et al. ( 2016 ) . Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study . PLOS Medicine vol. 13 , ( 6 ) e1001976 - e1001976 .

Bearden CE, Zandi P, Freimer NB ( 2016 ) . Molecular Architecture and Neurobiology of Bipolar Disorder . Genomics, Circuits, and Pathways in Clinical Neuropsychiatry ,

Scott RA, Freitag DF, Li L, Chu AY, Surendran P, Young R, Grarup N, Stancakova A et al. ( 2016 ) . A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease . Science Translational Medicine vol. 8 , ( 341 ) 341ra76 - 341ra76 .

Bodea CA, Neale BM, Ripke S, Daly MJ, Devlin B, Roeder K ( 2016 ) . A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies . American Journal of Human Genetics vol. 98 , ( 5 ) 857 - 868 .

Hemerich D, Tragante V, Harakalova M, Mokry M, Kerstens H, Munroe PB, Asselbergs FW ( 2016 ) . Fine mapping of blood pressure-related variants on epigenetic human data . European Journal of Clinical Investigation . Conference: 50th Annual Scientific Meeting of the European Society for Clinical Investigation ( Paris, France ) from: 27/04/2016 to: 29/04/2016 , vol. 46 , 120 - 120 .

Zhao Z, Wen W, Michailidou K, Bolla MK, Wang Q, Zhang B, Long J, Shu X-O et al. ( 2016 ) . Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry . Cancer Causes & Control vol. 27 , ( 5 ) 679 - 693 .

Fan Q, Verhoeven VJM, Wojciechowski R, Barathi VA, Hysi PG, Guggenheim JA, Höhn R, Vitart V et al. ( 2016 ) . Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error . Nature Communications vol. 7 , ( 1 )

Leusink M, der Zee AHM-V, Ding B, Drenos F, van Iperen EP, Warren HR, Caulfield MJ, Cupples LA et al. ( 2016 ) . A genetic risk score is associated with statin-induced low-density lipoprotein cholesterol lowering . Pharmacogenomics vol. 17 , ( 6 ) 583 - 591 .

Khawaja AP, Chan MPY, Yip JLY, Broadway DC, Garway-Heath DF, Luben R, Hayat S, Matthews FE et al. ( 2016 ) . Retinal Nerve Fiber Layer Measures and Cognitive Function in the EPIC-Norfolk Cohort Study . Invest Ophthalmol Vis Sci vol. 57 , ( 4 ) 1921 - 1926 .

Singh T, Kurki MI, Curtis D, Purcell SM, Crooks L, McRae J, Suvisaari J, Chheda H et al. ( 2016 ) . Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders . Nature Neuroscience vol. 19 , ( 4 ) 571 - 577 .

Noor NM, Banim PJR, Luben RN, Khaw K-T, Hart AR ( 2016 ) . Investigating Physical Activity in the Etiology of Pancreatic Cancer . Pancreas vol. 45 , ( 3 ) 388 - 393 .

Dunning AM, Michailidou K, Kuchenbaecker KB, Thompson D, French JD, Beesley J, Healey CS, Kar S et al. ( 2016 ) . Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170 . Nature Genetics vol. 48 , ( 4 ) 374 - 386 .

Easton DF, Lesueur F, Decker B, Michailidou K, Li J, Allen J, Luccarini C, Pooley KA et al. ( 2016 ) . No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing . Journal of Medical Genetics vol. 53 , ( 5 )

Diver LA, MacKenzie SM, Fraser R, McManus F, Freel EM, Alvarez-Madrazo S, McClure JD, Friel EC et al. ( 2016 ) . Common Polymorphisms at the CYP17A1 Locus Associate With Steroid Phenotype: Support for Blood Pressure Genome-Wide Association Study Signals at This Locus . Hypertension vol. 67 , ( 4 ) 724 - 732 .

Lessard S, Manning AK, Low-Kam C, Auer PL, Giri A, Graff M, Schurmann C, Yaghootkar H et al. ( 2016 ) . Testing the role of predicted gene knockouts in human anthropometric trait variation . Human Molecular Genetics vol. 25 , ( 10 ) 2082 - 2092 .

KEEVIL VL, COOPER AJM, WIJNDAELE K, LUBEN R, WAREHAM NJ, BRAGE S, KHAW K-T ( 2016 ) . Objective Sedentary Time, Moderate-to-Vigorous Physical Activity, and Physical Capability in a British Cohort . Medicine & Science in Sports & Exercise vol. 48 , ( 3 ) 421 - 429 .

Hibar DP, Westlye LT, van Erp TGM, Rasmussen J, Leonardo CD, Faskowitz J, Haukvik UK, Hartberg CB et al. ( 2016 ) . Subcortical volumetric abnormalities in bipolar disorder . Molecular Psychiatry vol. 21 , ( 12 ) 1710 - 1716 .

Franke B, Stein JL, Ripke S, Anttila V, Hibar DP, van Hulzen KJE, Arias-Vasquez A, Smoller JW et al. ( 2016 ) . Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept . Nature Neuroscience vol. 19 , ( 3 ) 420 - 431 .

Kwok CS, Loke YK, Welch AA, Luben RN, Lentjes MAH, Boekholdt SM, Pfister R, Mamas MA et al. ( 2016 ) . Habitual chocolate consumption and the risk of incident heart failure among healthy men and women . Nutrition Metabolism and Cardiovascular Diseases vol. 26 , ( 8 ) 722 - 734 .

Pattaro C, Teumer A, Gorski M, Chu AY, Li M, Mijatovic V, Garnaas M, Tin A et al. ( 2016 ) . Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function . Nature Communications vol. 7 , ( 1 )

Luben R, Hayat S, Wareham N, Khaw KT ( 2016 ) . Predicting admissions and time spent in hospital over a decade in a population-based record linkage study: the EPIC-Norfolk cohort . BMJ Open vol. 6 , ( 1 )

M'Rabet-Bensalah K, Aubert CE, Coslovsky M, Collet T-H, Baumgartner C, den Elzen WPJ, Luben R, Angelillo-Scherrer A et al. ( 2016 ) . Thyroid dysfunction and anaemia in a large population‐based study . Clinical Endocrinology vol. 84 , ( 4 ) 627 - 631 .

Berkemeyer K, Wijndaele K, White T, Cooper AJM, Luben R, Westgate K, Griffin SJ, Khaw KT et al. ( 2016 ) . The descriptive epidemiology of accelerometer-measured physical activity in older adults . International Journal of Behavioral Nutrition and Physical Activity vol. 13 , ( 1 )

Yaghootkar H, Bancks MP, Jones SE, McDaid AF, Beaumont R, Donnelly L, Wood AR, Campbell A et al. ( 2016 ) . Quantifying the Extent to Which Index Event Biases Influence Large Genetic Association Studies . HUMAN HEREDITY . vol. 81 , 214 - 214 .

Hayhoe RPG, Lentjes MAH, Luben RN, Khaw K-T, Welch AA ( 2016 ) . Reply to W Lin and R Wang . American Journal of Clinical Nutrition vol. 103 , ( 1 ) 290 - 291 .

Racine A, Carbonnel F, Chan SSM, Hart AR, Bueno-de-Mesquita HB, Oldenburg B, van Schaik FDM, Tjønneland A et al. ( 2015 ) . Dietary Patterns and Risk of Inflammatory Bowel Disease in Europe: Results from the EPIC Study . Inflammatory Bowel Diseases vol. 22 , ( 2 ) 345 - 354 .

Pagani L, St Clair PA, Teshiba TM, Service SK, Fears SC, Araya C, Araya X, Bejarano J et al. ( 2015 ) . Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorder . Proceedings of the National Academy of Sciences of the United States of America vol. 113 , ( 6 ) e754 - e761 .

Reppe S, Wang Y, Thompson WK, McEvoy LK, Schork AJ, Zuber V, LeBlanc M, Bettella F et al. ( 2015 ) . Genetic Sharing with Cardiovascular Disease Risk Factors and Diabetes Reveals Novel Bone Mineral Density Loci . PLOS ONE vol. 10 , ( 12 )

Stoekenbroek RM, Boekholdt SM, Luben R, Hovingh GK, Zwinderman AH, Wareham NJ, Khaw K-T, Peters RJG ( 2015 ) . Heterogeneous impact of classic atherosclerotic risk factors on different arterial territories: the EPIC-Norfolk prospective population study . European Heart Journal vol. 37 , ( 11 ) 880 - 889 .

Thompson DJ, O'Mara TA, Glubb DM, Painter JN, Cheng T, Folkerd E, Doody D, Dennis J et al. ( 2015 ) . CYP19A1 fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer . Endocrine Related Cancer vol. 23 , ( 2 ) 77 - 91 .

Bailey AL, Lauck M, Sibley SD, Friedrich TC, Kuhn JH, Freimer NB, Jasinska AJ, Phillips-Conroy JE et al. ( 2015 ) . Zoonotic Potential of Simian Arteriviruses . Journal of Virology vol. 90 , ( 2 ) 630 - 635 .

Finck H, Hart AR, Lentjes MAH, Jennings A, Luben RN, Khaw K-T, Welch AA ( 2015 ) . Cross-sectional and prospective associations between dietary and plasma vitamin C, heel bone ultrasound, and fracture risk in men and women in the European Prospective Investigation into Cancer in Norfolk cohort 1 . American Journal of Clinical Nutrition vol. 102 , ( 6 ) 1416 - 1424 .

Keevil VL, Luben R, Dalzell N, Hayat S, Sayer AA, Wareham NJ, Khaw K-T ( 2015 ) . Cross-sectional associations between different measures of obesity and muscle strength in men and women in a British cohort study . The journal of nutrition health & aging vol. 19 , ( 1 ) 3 - 11 .

Vilhjálmsson BJ, Yang J, Finucane HK, Gusev A, Lindström S, Ripke S, Genovese G, Loh P-R et al. ( 2015 ) . Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores . American Journal of Human Genetics vol. 97 , ( 4 ) 576 - 592 .

Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, Chu S, Czajkowski J, Esko T et al. ( 2015 ) . The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study . PLOS Genetics vol. 11 , ( 10 )

Wain LV, Shrine N, Miller S, Jackson VE, Ntalla I, Artigas MS, Billington CK, Kheirallah AK et al. ( 2015 ) . Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank . The Lancet Respiratory Medicine vol. 3 , ( 10 ) 769 - 781 .

Gallo V, Brayne C, Forsgren L, Barker RA, Petersson J, Hansson O, Lindqvist D, Ruffmann C et al. ( 2015 ) . Parkinson's Disease Case Ascertainment in the EPIC Cohort: The NeuroEPIC4PD Study . Neurodegenerative Diseases vol. 15 , ( 6 ) 331 - 338 .

Warren WC, Jasinska AJ, García-Pérez R, Svardal H, Tomlinson C, Rocchi M, Archidiacono N, Capozzi O et al. ( 2015 ) . The genome of the vervet (Chlorocebus aethiops sabaeus) . Genome Research vol. 25 , ( 12 ) 1921 - 1933 .

Lindström S, Thompson DJ, Paterson AD, Li J, Gierach GL, Scott C, Stone J, Douglas JA et al. ( 2015 ) . Erratum: Corrigendum: Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk . Nature Communications vol. 6 , ( 1 )

Lachman S, Peters RJ, Lentjes MA, Mulligan AA, Luben RN, Wareham NJ, Khaw K-T, Boekholdt SM ( 2015 ) . Ideal cardiovascular health and risk of cardiovascular events in the EPIC-Norfolk prospective population study . European Journal of Preventive Cardiology vol. 23 , ( 9 ) 986 - 994 .

MYINT PK, HAWKINS KR, CLARK AB, LUBEN RN, WAREHAM NJ, KHAW K-T, WILSON AM ( 2015 ) . Long-term mortality of hospitalized pneumonia in the EPIC-Norfolk cohort . Epidemiology and Infection vol. 144 , ( 4 ) 803 - 809 .

Haut KM, Karlsgodt KH, Bilder RM, Congdon E, Freimer NB, London ED, Sabb FW, Ventura J et al. ( 2015 ) . Memory systems in schizophrenia: Modularity is preserved but deficits are generalized . Schizophrenia Research vol. 168 , ( 1-2 ) 223 - 230 .

Lee SH, Byrne EM, Hultman CM, Kähler A, Vinkhuyzen AA, Ripke S, Andreassen OA, Frisell T et al. ( 2015 ) . New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis . International Journal of Epidemiology vol. 44 , ( 5 ) 1706 - 1721 .

Rudolph A, Fasching PA, Behrens S, Eilber U, Bolla MK, Wang Q, Thompson D, Czene K et al. ( 2015 ) . A comprehensive evaluation of interaction between genetic variants and use of menopausal hormone therapy on mammographic density . Breast Cancer Research vol. 17 , ( 1 )

Turner TR, Coetzer WG, Schmitt CA, Lorenz JG, Freimer NB, Grobler JP ( 2015 ) . Localized population divergence of vervet monkeys (Chlorocebus spp.) in South Africa: Evidence from mtDNA . American Journal of Biological Anthropology vol. 159 , ( 1 ) 17 - 30 .

Yip JLY, Khawaja AP, Chan MPY, Broadway DC, Peto T, Tufail A, Luben R, Hayat S et al. ( 2015 ) . Cross Sectional and Longitudinal Associations between Cardiovascular Risk Factors and Age Related Macular Degeneration in the EPIC-Norfolk Eye Study . PLOS ONE vol. 10 , ( 7 )

Hayhoe RPG, Lentjes MAH, Luben RN, Khaw K-T, Welch AA ( 2015 ) . Dietary magnesium and potassium intakes and circulating magnesium are associated with heel bone ultrasound attenuation and osteoporotic fracture risk in the EPIC-Norfolk cohort study 1 , 2 . American Journal of Clinical Nutrition vol. 102 , ( 2 ) 376 - 384 .

Joshi PK, Esko T, Mattsson H, Eklund N, Gandin I, Nutile T, Jackson AU, Schurmann C et al. ( 2015 ) . Directional dominance on stature and cognition in diverse human populations . Nature vol. 523 , ( 7561 ) 459 - 462 .

Khaw K-T, Luben R, Wareham N ( 2015 ) . Reply to WB Grant . American Journal of Clinical Nutrition vol. 102 , ( 1 ) 230 - 231 .

Munroe PB, Tinker A ( 2015 ) . Genome-wide association studies and contribution to cardiovascular physiology . Physiological Genomics vol. 47 , ( 9 ) 365 - 375 .

Huang YS, Ramensky V, Service SK, Jasinska AJ, Jung Y, Choi O-W, Cantor RM, Juretic N et al. ( 2015 ) . Sequencing strategies and characterization of 721 vervet monkey genomes for future genetic analyses of medically relevant traits . BMC Biology vol. 13 , ( 1 )

Kwok CS, Boekholdt SM, Lentjes MAH, Loke YK, Luben RN, Yeong JK, Wareham NJ, Myint PK et al. ( 2015 ) . Habitual chocolate consumption and risk of cardiovascular disease among healthy men and women . Heart vol. 101 , ( 16 )

Stone J, Thompson DJ, dos Santos Silva I, Scott C, Tamimi RM, Lindstrom S, Kraft P, Hazra A et al. ( 2015 ) . Novel Associations between Common Breast Cancer Susceptibility Variants and Risk-Predicting Mammographic Density Measures . Cancer Research vol. 75 , ( 12 ) 2457 - 2467 .

Darabi H, McCue K, Beesley J, Michailidou K, Nord S, Kar S, Humphreys K, Thompson D et al. ( 2015 ) . Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression . American Journal of Human Genetics vol. 97 , ( 1 ) 22 - 34 .

Bain LKM, Myint PK, Jennings A, Lentjes MAH, Luben RN, Khaw K-T, Wareham NJ, Welch AA ( 2015 ) . The relationship between dietary magnesium intake, stroke and its major risk factors, blood pressure and cholesterol, in the EPIC-Norfolk cohort . International Journal of Cardiology vol. 196 , 108 - 114 .

Cornelis MC, Byrne EM, Esko T, Nalls MA, Ganna A, Paynter N, Monda KL, Amin N et al. ( 2015 ) . Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption . Molecular Psychiatry vol. 20 , ( 5 ) 647 - 656 .

Saleheen D, Scott R, Javad S, Zhao W, Rodrigues A, Picataggi A, Lukmanova D, Mucksavage ML et al. ( 2015 ) . Association of HDL cholesterol efflux capacity with incident coronary heart disease events: a prospective case-control study . The Lancet Diabetes & Endocrinology vol. 3 , ( 7 ) 507 - 513 .

Kapusinszky B, Mulvaney U, Jasinska AJ, Deng X, Freimer N, Delwart E ( 2015 ) . Local Virus Extinctions following a Host Population Bottleneck . Journal of Virology vol. 89 , ( 16 ) 8152 - 8161 .

Vogiatzoglou A, Mulligan AA, Lentjes MAH, Luben RN, Spencer JPE, Schroeter H, Khaw K-T, Kuhnle GGC ( 2015 ) . Flavonoid Intake in European Adults (18 to 64 Years) . PLOS ONE vol. 10 , ( 5 )

Blum MR, Bauer DC, Collet T-H, Fink HA, Cappola AR, da Costa BR, Wirth CD, Peeters RP et al. ( 2015 ) . Subclinical Thyroid Dysfunction and Fracture Risk: A Meta-analysis . JAMA vol. 313 , ( 20 ) 2055 - 2065 .

Ahmadi-Abhari S, Kaptoge S, Luben RN, Wareham NJ, Khaw K-T ( 2015 ) . Longitudinal association of C-reactive protein and Haemoglobin A1c over 13 years: the European Prospective Investigation into Cancer - Norfolk study . Cardiovascular Diabetology vol. 14 , ( 1 )

Fears SC, Schür R, Sjouwerman R, Service SK, Araya C, Araya X, Bejarano J, Knowles E et al. ( 2015 ) . Brain structure–function associations in multi-generational families genetically enriched for bipolar disorder . Brain vol. 138 , ( 7 ) 2087 - 2102 .

Monsivais P, Scarborough P, Lloyd T, Mizdrak A, Luben R, Mulligan AA, Wareham NJ, Woodcock J ( 2015 ) . Greater accordance with the Dietary Approaches to Stop Hypertension dietary pattern is associated with lower diet-related greenhouse gas production but higher dietary costs in the United Kingdom 1 , 2 . American Journal of Clinical Nutrition vol. 102 , ( 1 ) 138 - 145 .

Yousaf N, Low WY, Onipinla A, Mein C, Caulfield M, Munroe PB, Chernajovsky Y ( 2015 ) . Differences between disease-associated endoplasmic reticulum aminopeptidase 1 (ERAP1) isoforms in cellular expression, interactions with tumour necrosis factor receptor 1 (TNF-R1) and regulation by cytokines . Clinical & Experimental Immunology vol. 180 , ( 2 ) 289 - 304 .

Chaker L, Baumgartner C, Elzen WPJD, Ikram MA, Blum MR, Collet T-H, Bakker SJL, Dehghan A et al. ( 2015 ) . Subclinical Hypothyroidism and the Risk of Stroke Events and Fatal Stroke: An Individual Participant Data Analysis . The Journal of Clinical Endocrinology & Metabolism vol. 100 , ( 6 ) 2181 - 2191 .

Mavaddat N, Pharoah PDP, Michailidou K, Tyrer J, Brook MN, Bolla MK, Wang Q, Dennis J et al. ( 2015 ) . Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants . Journal of the National Cancer Institute vol. 107 , ( 5 )

Hirschtritt ME, Lee PC, Pauls DL, Dion Y, Grados MA, Illmann C, King RA, Sandor P et al. ( 2015 ) . Lifetime Prevalence, Age of Risk, and Genetic Relationships of Comorbid Psychiatric Disorders in Tourette Syndrome . JAMA Psychiatry vol. 72 , ( 4 ) 325 - 333 .

Huffman JE, Albrecht E, Teumer A, Mangino M, Kapur K, Johnson T, Kutalik Z, Pirastu N et al. ( 2015 ) . Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans . PLOS ONE vol. 10 , ( 3 )

Huan T, Esko T, Peters MJ, Pilling LC, Schramm K, Schurmann C, Chen BH, Liu C et al. ( 2015 ) . A Meta-analysis of Gene Expression Signatures of Blood Pressure and Hypertension . PLOS Genetics vol. 11 , ( 3 )

Vogiatzoglou A, Mulligan AA, Bhaniani A, Lentjes MAH, McTaggart A, Luben RN, Heiss C, Kelm M et al. ( 2015 ) . Associations between flavan-3-ol intake and CVD risk in the Norfolk cohort of the European Prospective Investigation into Cancer (EPIC-Norfolk) . Free Radical Biology and Medicine vol. 84 , 1 - 10 .

KEEVIL VL, WIJNDAELE K, LUBEN R, SAYER AA, WAREHAM NJ, KHAW K-T ( 2015 ) . Television Viewing, Walking Speed, and Grip Strength in a Prospective Cohort Study . Medicine & Science in Sports & Exercise vol. 47 , ( 4 ) 735 - 742 .

Ligthart S, de Vries PS, Uitterlinden AG, Hofman A, Franco OH, Chasman DI, Dehghan A ( 2015 ) . Pleiotropy among Common Genetic Loci Identified for Cardiometabolic Disorders and C-Reactive Protein . PLOS ONE vol. 10 , ( 3 )

Fagerholm R, Schmidt MK, Khan S, Rafiq S, Tapper W, Aittomäki K, Greco D, Heikkinen T et al. ( 2015 ) . The SNP rs6500843 in 16p13.3 is associated with survival specifically among chemotherapy-treated breast cancer patients . Oncotarget vol. 6 , ( 10 ) 7390 - 7407 .

de Leeuw C, Goudriaan A, Smit AB, Yu D, Mathews CA, Scharf JM, Verheijen MHG, Posthuma D ( 2015 ) . Involvement of astrocyte metabolic coupling in Tourette syndrome pathogenesis . European Journal of Human Genetics vol. 23 , ( 11 ) 1519 - 1522 .

Leng Y, Cappuccio FP, Wainwright NWJ, Surtees PG, Luben R, Brayne C, Khaw K-T ( 2015 ) . Sleep duration and risk of fatal and nonfatal stroke . Neurology vol. 84 , ( 11 ) 1072 - 1079 .

Kuhnle GG, Tasevska N, Lentjes MA, Griffin JL, Sims MA, Richardson L, Aspinall SM, Mulligan AA et al. ( 2015 ) . Association between sucrose intake and risk of overweight and obesity in a prospective sub-cohort of the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) . Public Health Nutrition vol. 18 , ( 15 ) 2815 - 2824 .

Yip JLY, Khawaja AP, Chan MPY, Broadway DC, Peto T, Luben R, Hayat S, Bhaniani A et al. ( 2015 ) . Area deprivation and age related macular degeneration in the EPIC-Norfolk Eye Study . Public Health vol. 129 , ( 2 ) 103 - 109 .

Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S et al. ( 2015 ) . Genetic studies of body mass index yield new insights for obesity biology . Nature vol. 518 , ( 7538 ) 197 - 206 .

Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Mägi R, Strawbridge RJ, Pers TH et al. ( 2015 ) . New genetic loci link adipose and insulin biology to body fat distribution . Nature vol. 518 , ( 7538 ) 187 - 196 .

Lei J, Rudolph A, Moysich KB, Rafiq S, Behrens S, Goode EL, Pharoah PP, Seibold P et al. ( 2015 ) . Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with prognosis of estrogen receptor-negative breast cancer after chemotherapy . Breast Cancer Research vol. 17 , ( 1 )

Cabrera CP, Ng FL, Warren HR, Barnes MR, Munroe PB, Caulfield MJ ( 2015 ) . Exploring hypertension genome‐wide association studies findings and impact on pathophysiology, pathways, and pharmacogenetics . WIREs Mechanisms of Disease vol. 7 , ( 2 ) 73 - 90 .

Bulik-Sullivan BK, Loh P-R, Finucane HK, Ripke S, Yang J, Patterson N, Daly MJ, Price AL et al. ( 2015 ) . LD Score regression distinguishes confounding from polygenicity in genome-wide association studies . Nature Genetics vol. 47 , ( 3 ) 291 - 295 .

O'Dushlaine C, Rossin L, Lee PH, Duncan L, Parikshak NN, Newhouse S, Ripke S, Neale BM et al. ( 2015 ) . Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways . NATURE NEUROSCIENCE vol. 18 , ( 2 ) 199 - 209 .

Maier R, Moser G, Chen G-B, Ripke S, Consortium C-DWGOTPG, Absher D, Agartz I, Akil H et al. ( 2015 ) . Joint Analysis of Psychiatric Disorders Increases Accuracy of Risk Prediction for Schizophrenia, Bipolar Disorder, and Major Depressive Disorder . American Journal of Human Genetics vol. 96 , ( 2 ) 283 - 294 .

Rodríguez RL, Cramer JD, Schmitt CA, Gaetano TJ, Grobler JP, Freimer NB, Turner TR ( 2015 ) . Adult age confounds estimates of static allometric slopes in a vertebrate . Ethology Ecology & Evolution vol. 27 , ( 4 ) 412 - 421 .

Warren HR, Surendran P, Drenos F, Young R, Cook JP, Manning AK, Grarup N, Sim X et al. ( 2015 ) . Investigating the Association of Rare Genetic Variants with Blood Pressure traits . GENETIC EPIDEMIOLOGY . vol. 39 , 591 - 591 .

Warren H, Sever P, Poulter N, Stanton A, Caulfield M, Munroe P ( 2015 ) . Pharmacogenetic GWAS meta-analysis of response to antihypertensive drugs . JOURNAL OF HUMAN HYPERTENSION vol. 29 , ( 10 ) 627 - 627 .

Warren H, Sever P, Poulter N, Stantont A, Caulfield M, Munroe P ( 2015 ) . Pharmacogenetic Meta-Analysis of Response to Antihypertensive Drugs within ASCOT . HUMAN HEREDITY . vol. 79 , 49 - 49 .

Rodríguez RL, Cramer JD, Schmitt CA, Gaetano TJ, Grobler JP, Freimer NB, Turner TR ( 2014 ) . The static allometry of sexual and nonsexual traits in vervet monkeys . Biological Journal of the Linnean Society vol. 114 , ( 3 ) 527 - 537 .

Hayat SA, Luben R, Moore S, Dalzell N, Bhaniani A, Anuj S, Matthews FE, Wareham N et al. ( 2014 ) . Cognitive function in a general population of men and women: a cross sectional study in the European Investigation of Cancer–Norfolk cohort (EPIC-Norfolk) . BMC Geriatrics vol. 14 , ( 1 )

Yaghootkar H, Scott RA, White CC, Zhang W, Speliotes E, Munroe PB, Ehret GB, Bis JC et al. ( 2014 ) . Genetic evidence for a normal-weight "metabolically obese" phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes . Diabetes vol. 63 , ( 12 ) 4369 - 4377 .

McCarthy NS, Vangjeli C, Cavalleri GL, Delanty N, Shianna KV, Surendran P, O'Brien E, Munroe PB et al. ( 2014 ) . Two further blood pressure loci identified in ion channel genes with a gene-centric approach . Circ Cardiovasc Genet vol. 7 , ( 6 ) 873 - 879 .

Myint PK, Fox C, Kwok CS, Luben RN, Wareham NJ, Khaw K-T ( 2014 ) . Total anticholinergic burden and risk of mortality and cardiovascular disease over 10 years in 21,636 middle-aged and older men and women of EPIC-Norfolk prospective population study . Age and Ageing vol. 44 , ( 2 ) 219 - 225 .

Khan S, Greco D, Michailidou K, Milne RL, Muranen TA, Heikkinen T, Aaltonen K, Dennis J et al. ( 2014 ) . MicroRNA Related Polymorphisms and Breast Cancer Risk . PLOS ONE vol. 9 , ( 11 )

Cooper AJM, Sharp SJ, Luben RN, Khaw K-T, Wareham NJ, Forouhi NG ( 2014 ) . The association between a biomarker score for fruit and vegetable intake and incident type 2 diabetes: the EPIC-Norfolk study . European Journal of Clinical Nutrition vol. 69 , ( 4 ) 449 - 454 .

Leng Y, Ahmadi-Abhari S, Wainwright NWJ, Cappuccio FP, Surtees PG, Luben R, Brayne C, Khaw K-T ( 2014 ) . Daytime napping, sleep duration and serum C reactive protein: a population-based cohort study . BMJ Open vol. 4 , ( 11 )

Gusev A, Lee SH, Trynka G, Finucane H, Vilhjálmsson BJ, Xu H, Zang C, Ripke S et al. ( 2014 ) . Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases . American Journal of Human Genetics vol. 95 , ( 5 ) 535 - 552 .

Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K et al. ( 2014 ) . Defining the role of common variation in the genomic and biological architecture of adult human height . Nature Genetics vol. 46 , ( 11 ) 1173 - 1186 .

Pfister R, Michels G, Brägelmann J, Sharp SJ, Luben R, Wareham NJ, Khaw K-T ( 2014 ) . Plasma vitamin C and risk of hospitalisation with diagnosis of atrial fibrillation in men and women in EPIC-Norfolk prospective study . International Journal of Cardiology vol. 177 , ( 3 ) 830 - 835 .

Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K et al. ( 2014 ) . Defining the role of common variation in the genomic and biological architecture of adult human height . Nat Genet vol. 46 , ( 11 ) 1173 - 1186 .

Yu D, Mathews CA, Scharf JM, Neale BM, Davis LK, Gamazon ER, Derks EM, Evans P et al. ( 2014 ) . Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette’s Syndrome and OCD . American Journal of Psychiatry vol. 172 , ( 1 ) 82 - 93 .

Postmus I, Trompet S, Deshmukh HA, Barnes MR, Li X, Warren HR, Chasman DI, Zhou K et al. ( 2014 ) . Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins . Nat Commun vol. 5 ,

Lindström S, Thompson DJ, Paterson AD, Li J, Gierach GL, Scott C, Stone J, Douglas JA et al. ( 2014 ) . Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk . Nature Communications vol. 5 , ( 1 )

Pfister R, Michels G, Sharp SJ, Luben R, Wareham NJ, Khaw K-T ( 2014 ) . Inverse association between bone mineral density and risk of aortic stenosis in men and women in EPIC–Norfolk prospective study . International Journal of Cardiology vol. 178 , 29 - 30 .

Lentjes MAH, Welch AA, Mulligan AA, Luben RN, Wareham NJ, Khaw K-T ( 2014 ) . Cod Liver Oil Supplement Consumption and Health: Cross-sectional Results from the EPIC-Norfolk Cohort Study . Nutrients vol. 6 , ( 10 ) 4320 - 4337 .

Cornelis MC, Byrne EM, Esko T, Nalls MA, Ganna A, Paynter N, Monda KL, Amin N et al. ( 2014 ) . Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption . Molecular Psychiatry vol. 20 , ( 5 ) 647 - 656 .

( 2014 ) . Erratum . South African Journal of Wildlife Research vol. 44 , ( 2 ) 202 - 202 .

Chan SSM, Luben R, van Schaik F, Oldenburg B, Bueno-de-Mesquita HB, Hallmans G, Karling P, Lindgren S et al. ( 2014 ) . Carbohydrate Intake in the Etiology of Crohn's Disease and Ulcerative Colitis . Inflammatory Bowel Diseases vol. 20 , ( 11 ) 2013 - 2021 .

Pfister R, Michels G, Sharp SJ, Luben R, Wareham NJ, Khaw K-T ( 2014 ) . Reply The Importance of Ventricular-Vascular Uncoupling . JACC Heart Failure vol. 3 , ( 1 ) 95 - 96 .

Ghoussaini M, Edwards SL, Michailidou K, Nord S, Cowper-Sal·lari R, Desai K, Kar S, Hillman KM et al. ( 2014 ) . Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation . Nature Communications vol. 5 , ( 1 )

Khaw K-T, Luben R, Wareham N ( 2014 ) . Serum 25-hydroxyvitamin D, mortality, and incident cardiovascular disease, respiratory disease, cancers, and fractures: a 13-y prospective population study 1 , 2 , 3 , 4 . American Journal of Clinical Nutrition vol. 100 , ( 5 ) 1361 - 1370 .

Lentjes MAH, Mulligan AA, Welch AA, Bhaniani A, Luben RN, Khaw K-T ( 2014 ) . Contribution of cod liver oil‐related nutrients (vitamins A, D, E and eicosapentaenoic acid and docosahexaenoic acid) to daily nutrient intake and their associations with plasma concentrations in the EPIC‐Norfolk cohort . Journal of Human Nutrition and Dietetics vol. 28 , ( 6 ) 568 - 582 .

Shohaimi S, Boekholdt MS, Luben R, Wareham NJ, Khaw K-T ( 2014 ) . Distribution of lipid parameters according to different socio-economic indicators- the EPIC-Norfolk prospective population study . BMC Public Health vol. 14 , ( 1 )

Holmes MV, Frikke-Schmidt R, Melis D, Luben R, Asselbergs FW, Boer JMA, Cooper J, Palmen J et al. ( 2014 ) . A systematic review and meta-analysis of 130,000 individuals shows smoking does not modify the association of APOE genotype on risk of coronary heart disease . Atherosclerosis vol. 237 , ( 1 ) 5 - 12 .

Qi Q, Kilpeläinen TO, Downer MK, Tanaka T, Smith CE, Sluijs I, Sonestedt E, Chu AY et al. ( 2014 ) . FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals . Human Molecular Genetics vol. 23 , ( 25 ) 6961 - 6972 .

White CN, Congdon E, Mumford JA, Karlsgodt KH, Sabb FW, Freimer NB, London ED, Cannon TD et al. ( 2014 ) . Decomposing Decision Components in the Stop-signal Task: A Model-based Approach to Individual Differences in Inhibitory Control . Journal of Cognitive Neuroscience vol. 26 , ( 8 ) 1601 - 1614 .

Arking DE, Pulit SL, Crotti L, van der Harst P, Munroe PB, Koopmann TT, Sotoodehnia N, Rossin EJ et al. ( 2014 ) . Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization . Nat Genet vol. 46 , ( 8 ) 826 - 836 .

Lim ET, Würtz P, Havulinna AS, Palta P, Tukiainen T, Rehnström K, Esko T, Mägi R et al. ( 2014 ) . Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population . PLOS Genetics vol. 10 , ( 7 )

Hoggart CJ, Venturini G, Mangino M, Gomez F, Ascari G, Zhao JH, Teumer A, Winkler TW et al. ( 2014 ) . Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index . PLOS Genetics vol. 10 , ( 7 )

Lentjes MA, Welch AA, Keogh RH, Luben RN, Khaw K-T ( 2014 ) . Opposites don’t attract: high spouse concordance for dietary supplement use in the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) cohort study . Public Health Nutrition vol. 18 , ( 6 ) 1060 - 1066 .

Pfister R, Brägelmann J, Michels G, Wareham NJ, Luben R, Khaw K-T ( 2014 ) . Performance of the CHARGE-AF risk model for incident atrial fibrillation in the EPIC Norfolk cohort . European Journal of Preventive Cardiology vol. 22 , ( 7 ) 932 - 939 .

( 2014 ) . Biological insights from 108 schizophrenia-associated genetic loci . Nature vol. 511 , ( 7510 ) 421 - 427 .

Paschou P, Yu D, Gerber G, Evans P, Tsetsos F, Davis LK, Karagiannidis I, Chaponis J et al. ( 2014 ) . Genetic association signal near NTN4 in Tourette syndrome . Annals of Neurology vol. 76 , ( 2 ) 310 - 315 .

Pfister R, Michels G, Sharp SJ, Luben R, Wareham NJ, Khaw K-T ( 2014 ) . Low Bone Mineral Density Predicts Incident Heart Failure in Men and Women The EPIC (European Prospective Investigation Into Cancer and Nutrition)–Norfolk Prospective Study . JACC Heart Failure vol. 2 , ( 4 ) 380 - 389 .

Ganesh SK, Chasman DI, Larson MG, Guo X, Verwoert G, Bis JC, Xiangjun GU, Smith AV et al. ( 2014 ) . Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations . American Journal of Human Genetics vol. 95 , ( 1 ) 49 - 65 .

Ganesh SK, Chasman DI, Larson MG, Guo X, Verwoert G, Bis JC, Gu X, Smith AV et al. ( 2014 ) . Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations . Am J Hum Genet vol. 95 , ( 1 ) 49 - 65 .

Patel PS, Cooper AJM, O'Connell TC, Kuhnle GGC, Kneale CK, Mulligan AM, Luben RN, Brage S et al. ( 2014 ) . Serum carbon and nitrogen stable isotopes as potential biomarkers of dietary intake and their relation with incident type 2 diabetes: the EPIC-Norfolk study 1 , 2 , 3 . American Journal of Clinical Nutrition vol. 100 , ( 2 ) 708 - 718 .

Nicodemus KK, Hargreaves A, Morris D, Anney R, Gill M, Corvin A, Donohoe G ( 2014 ) . Variability in Working Memory Performance Explained by Epistasis vs Polygenic Scores in the ZNF804A Pathway . JAMA Psychiatry vol. 71 , ( 7 ) 778 - 785 .

Myint PK, Kwok CS, Luben RN, Wareham NJ, Khaw K-T ( 2014 ) . Body fat percentage, body mass index and waist-to-hip ratio as predictors of mortality and cardiovascular disease . Heart vol. 100 , ( 20 )

McGrath LM, Yu D, Marshall C, Davis LK, Thiruvahindrapuram B, Li B, Cappi C, Gerber G et al. ( 2014 ) . Copy Number Variation in Obsessive-Compulsive Disorder and Tourette Syndrome: A Cross-Disorder Study . Journal of the American Academy of Child & Adolescent Psychiatry vol. 53 , ( 8 ) 910 - 919 .

Li J, Lindström LS, Foo JN, Rafiq S, Schmidt MK, Pharoah PDP, Michailidou K, Dennis J et al. ( 2014 ) . 2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy . Nature Communications vol. 5 , ( 1 )

Addison S, Munroe P, Mein C, Cohen M, Fowler D, Sebire NJ, Peebles D, Taylor A et al. ( 2014 ) . 8.2 cardiac ion channelopathies in unexplained stillbirths . Arch Dis Child Fetal Neonatal Ed vol. 99 Suppl 1 ,

Sotos-Prieto M, Luben R, Khaw K-T, Wareham NJ, Forouhi NG ( 2014 ) . The association between Mediterranean Diet Score and glucokinase regulatory protein gene variation on the markers of cardiometabolic risk: an analysis in the European Prospective Investigation into Cancer (EPIC)-Norfolk study . British Journal Of Nutrition vol. 112 , ( 1 ) 122 - 131 .

Khawaja AP, Chan MPY, Broadway DC, Garway-Heath DF, Luben R, Yip JLY, Hayat S, Wareham NJ et al. ( 2014 ) . Systemic Medication and Intraocular Pressure in a British Population The EPIC-Norfolk Eye Study . Ophthalmology vol. 121 , ( 8 ) 1501 - 1507 .

Gaetano TJ, Danzy J, Mtshali MS, Theron N, Schmitt CA, Grobler JP, Freimer N, Turner TR ( 2014 ) . Mapping Correlates of Parasitism in Wild South African Vervet Monkeys (Chlorocebus aethiops) . South African Journal of Wildlife Research vol. 44 , ( 1 ) 56 - 70 .

Fears SC, Service SK, Kremeyer B, Araya C, Araya X, Bejarano J, Ramirez M, Castrillón G et al. ( 2014 ) . Multisystem Component Phenotypes of Bipolar Disorder for Genetic Investigations of Extended Pedigrees . JAMA Psychiatry vol. 71 , ( 4 ) 375 - 387 .

Leng Y, Wainwright NWJ, Cappuccio FP, Surtees PG, Hayat S, Luben R, Brayne C, Khaw K-T ( 2014 ) . Daytime Napping and the Risk of All-Cause and Cause-Specific Mortality: A 13-Year Follow-up of a British Population . American Journal of Epidemiology vol. 179 , ( 9 ) 1115 - 1124 .

Mulligan AA, Luben RN, Bhaniani A, Parry-Smith DJ, O'Connor L, Khawaja AP, Forouhi NG, Khaw K-T et al. ( 2014 ) . A new tool for converting food frequency questionnaire data into nutrient and food group values: FETA research methods and availability . BMJ Open vol. 4 , ( 3 )

Ma D, Jasinska AJ, Feyertag F, Wijewardana V, Kristoff J, He T, Raehtz K, Schmitt CA et al. ( 2014 ) . Factors Associated with Siman Immunodeficiency Virus Transmission in a Natural African Nonhuman Primate Host in the Wild . Journal of Virology vol. 88 , ( 10 ) 5687 - 5705 .

Tragante V, Barnes MR, Ganesh SK, Lanktree MB, Guo W, Franceschini N, Smith EN, Johnson T et al. ( 2014 ) . Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci . Am J Hum Genet vol. 94 , ( 3 ) 349 - 360 .

Chan SSM, Luben R, Olsen A, Tjonneland A, Kaaks R, Lindgren S, Grip O, Bergmann MM et al. ( 2014 ) . Association between high dietary intake of the n−3 polyunsaturated fatty acid docosahexaenoic acid and reduced risk of Crohn's disease . Alimentary Pharmacology & Therapeutics vol. 39 , ( 8 ) 834 - 842 .

Pfister R, Michels G, Sharp SJ, Luben R, Wareham NJ, Khaw K ( 2014 ) . Resting heart rate and incident heart failure in apparently healthy men and women in the EPIC‐Norfolk study . European Journal of Heart Failure vol. 14 , ( 10 ) 1163 - 1170 .

O’Connor LM, Lentjes MAH, Luben RN, Khaw K-T, Wareham NJ, Forouhi NG ( 2014 ) . Dietary dairy product intake and incident type 2 diabetes: a prospective study using dietary data from a 7-day food diary . Diabetologia vol. 57 , ( 5 ) 909 - 917 .

Yates M, Cheong E, Luben R, Igali L, Fitzgerald R, Khaw K-T, Hart A ( 2014 ) . Body Mass Index, Smoking, and Alcohol and Risks of Barrett’s Esophagus and Esophageal Adenocarcinoma: A UK Prospective Cohort Study . Digestive Diseases and Sciences vol. 59 , ( 7 ) 1552 - 1559 .

Munroe P ( 2014 ) . Genome scans for hypertension . vol. 2014 , ( 2 )

Service SK, Teslovich TM, Fuchsberger C, Ramensky V, Yajnik P, Koboldt DC, Larson DE, Zhang Q et al. ( 2014 ) . Re-sequencing Expands Our Understanding of the Phenotypic Impact of Variants at GWAS Loci . PLOS Genetics vol. 10 , ( 1 )

Pfister R, Luben RN, Khaw K, Wareham NJ ( 2014 ) . Common genetic variants of the natriuretic peptide gene locus are not associated with heart failure risk in participants in the EPIC‐Norfolk study . European Journal of Heart Failure vol. 15 , ( 6 ) 624 - 627 .

Pfister R, Michels G, Sharp SJ, Luben R, Wareham NJ, Khaw K ( 2014 ) . Estimated urinary sodium excretion and risk of heart failure in men and women in the EPIC‐Norfolk study . European Journal of Heart Failure vol. 16 , ( 4 ) 394 - 402 .

Leng Y, Wainwright NWJ, Cappuccio FP, Surtees PG, Luben R, Wareham N, Brayne C, Khaw K-T ( 2014 ) . Self-reported sleep patterns in a British population cohort . Sleep Medicine vol. 15 , ( 3 ) 295 - 302 .

Moayyeri A, Hsu Y-H, Karasik D, Estrada K, Xiao S-M, Nielson C, Srikanth P, Giroux S et al. ( 2014 ) . Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium . Human Molecular Genetics vol. 23 , ( 11 ) 3054 - 3068 .

Thompson PM, Stein JL, Medland SE, Hibar DP, Vasquez AA, Renteria ME, Toro R, Jahanshad N et al. ( 2014 ) . The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data . Brain Imaging and Behavior vol. 8 , ( 2 ) 153 - 182 .

Myint PK, Clark AB, Kwok CS, Loke YK, Yeong JK-Y, Luben RN, Wareham NJ, Khaw K-T ( 2014 ) . Bone Mineral Density and Incidence of Stroke . Stroke vol. 45 , ( 2 ) 373 - 382 .

Khawaja AP, Chan MPY, Broadway DC, Garway-Heath DF, Luben R, Yip JLY, Hayat S, Khaw K-T et al. ( 2014 ) . Corneal Biomechanical Properties and Glaucoma-Related Quantitative Traits in the EPIC-Norfolk Eye StudyCorneal Hysteresis and Glaucoma-Related Traits . Investigative Ophthalmology & Visual Science vol. 55 , ( 1 ) 117 - 124 .

de Silva PSA, Luben R, Shrestha SS, Khaw KT, Hart AR ( 2014 ) . Dietary arachidonic and oleic acid intake in ulcerative colitis etiology . European Journal of Gastroenterology & Hepatology vol. 26 , ( 1 ) 11 - 18 .

Yoneyama S, Guo Y, Lanktree MB, Barnes MR, Elbers CC, Karczewski KJ, Padmanabhan S, Bauer F et al. ( 2014 ) . Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations . HUMAN MOLECULAR GENETICS vol. 23 , ( 9 ) 2498 - 2510 .

Yaghootkar H, Scott R, White CC, Zhang W, Speliotes EK, Munroe PB, Ehret GB, Bis JC et al. ( 2014 ) . Genetic Evidence for a Metabolically Obese, Normal Weight Phenotype That Links Insulin Resistance with Type 2 Diabetes, Hypertension, and Coronary Artery Disease . DIABETES . vol. 63 , A414 - A414 .

Dobson RJB, Munroe PB, Caulfield MJ, Saqi MAS ( 2014 ) . Protein interaction networks associated with cardiovascular disease and cancer: exploring the effect of bias on shared network properties . INTERNATIONAL JOURNAL OF DATA MINING AND BIOINFORMATICS vol. 9 , ( 4 ) 339 - 357 .

Kunutsor SK, Burgess S, Munroe PB, Khan H ( 2014 ) . Vitamin D and high blood pressure: causal association or epiphenomenon? . EUROPEAN JOURNAL OF EPIDEMIOLOGY vol. 29 , ( 1 ) 1 - 14 .

Oei L, Hsu Y-H, Styrkarsdottir U, Eussen BH, de Klein A, Peters MJ, Halldorsson B, Liu C-T et al. ( 2013 ) . A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus . Journal of Medical Genetics vol. 51 , ( 2 )

Vogiatzoglou A, Mulligan AA, Luben RN, Lentjes MAH, Heiss C, Kelm M, Merx MW, Spencer JPE et al. ( 2013 ) . Assessment of the dietary intake of total flavan-3-ols, monomeric flavan-3-ols, proanthocyanidins and theaflavins in the European Union . British Journal Of Nutrition vol. 111 , ( 8 ) 1463 - 1473 .

Yip JLY, Khawaja AP, Broadway D, Luben R, Hayat S, Dalzell N, Bhaniani A, Wareham N et al. ( 2013 ) . Visual acuity, self-reported vision and falls in the EPIC-Norfolk Eye study . British Journal of Ophthalmology vol. 98 , ( 3 )

Sahlqvist S, Goodman A, Simmons RK, Khaw K-T, Cavill N, Foster C, Luben R, Wareham NJ et al. ( 2013 ) . The association of cycling with all-cause, cardiovascular and cancer mortality: findings from the population-based EPIC-Norfolk cohort . BMJ Open vol. 3 , ( 11 )

Do R, Willer CJ, Schmidt EM, Sengupta S, Gao C, Peloso GM, Gustafsson S, Kanoni S et al. ( 2013 ) . Common variants associated with plasma triglycerides and risk for coronary artery disease . Nature Genetics vol. 45 , ( 11 ) 1345 - 1353 .

Do R, Willer CJ, Schmidt EM, Sengupta S, Gao C, Peloso GM, Gustafsson S, Kanoni S et al. ( 2013 ) . Common variants associated with plasma triglycerides and risk for coronary artery disease . Nat Genet vol. 45 , ( 11 ) 1345 - 1352 .

Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J et al. ( 2013 ) . Discovery and refinement of loci associated with lipid levels . Nat Genet vol. 45 , ( 11 ) 1274 - 1283 .

Yip JLY, Luben R, Hayat S, Khawaja AP, Broadway DC, Wareham N, Khaw KT, Foster PJ ( 2013 ) . Area deprivation, individual socioeconomic status and low vision in the EPIC-Norfolk Eye Study . Journal of Epidemiology & Community Health vol. 68 , ( 3 )

Davis LK, Yu D, Keenan CL, Gamazon ER, Konkashbaev AI, Derks EM, Neale BM, Yang J et al. ( 2013 ) . Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture . PLOS Genetics vol. 9 , ( 10 )

Khawaja AP, Chan MPY, Broadway DC, Garway-Heath DF, Luben R, Yip JLY, Hayat S, Khaw K-T et al. ( 2013 ) . Laser Scanning Tomography in the EPIC-Norfolk Eye Study: Principal Components and AssociationsHRT Measures in the EPIC-Norfolk Eye Study . Investigative Ophthalmology & Visual Science vol. 54 , ( 10 ) 6638 - 6645 .

Thorgeirsson TE, Gudbjartsson DF, Sulem P, Besenbacher S, Styrkarsdottir U, Thorleifsson G, Walters GB, Furberg H et al. ( 2013 ) . A common biological basis of obesity and nicotine addiction . Translational Psychiatry vol. 3 , ( 10 ) e308 - e308 .

Yadav S, Cotlarciuc I, Munroe PB, Khan MS, Nalls MA, Bevan S, Cheng Y-C, Chen W-M et al. ( 2013 ) . Genome-wide analysis of blood pressure variability and ischemic stroke . Stroke vol. 44 , ( 10 ) 2703 - 2709 .

Ahmadi-Abhari S, Kaptoge S, Luben RN, Wareham NJ, Khaw K-T ( 2013 ) . Longitudinal Association of C-Reactive Protein and Lung Function Over 13 Years . American Journal of Epidemiology vol. 179 , ( 1 ) 48 - 56 .

Keevil VL, Hayat S, Dalzell N, Moore S, Bhaniani A, Luben R, Wareham NJ, Khaw K-T ( 2013 ) . The physical capability of community-based men and women from a British cohort: the European Prospective Investigation into Cancer (EPIC)-Norfolk study . BMC Geriatrics vol. 13 , ( 1 )

Lentjes MAH, McTaggart A, Mulligan AA, Powell NA, Parry-Smith D, Luben RN, Bhaniani A, Welch AA et al. ( 2013 ) . Dietary intake measurement using 7 d diet diaries in British men and women in the European Prospective Investigation into Cancer-Norfolk study: a focus on methodological issues . British Journal Of Nutrition vol. 111 , ( 3 ) 516 - 526 .

Munroe PB, Johnson T ( 2013 ) . Hypertension . Genomic and Personalized Medicine , vol. 2 ,

( 2013 ) . Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs . Nature Genetics vol. 45 , ( 9 ) 984 - 994 .

Vogiatzoglou A, Heuer T, Mulligan AA, Lentjes MAH, Luben RN, Kuhnle GGC ( 2013 ) . Estimated dietary intakes and sources of flavanols in the German population (German National Nutrition Survey II) . European Journal of Nutrition vol. 53 , ( 2 ) 635 - 643 .

Stoll G, Pietiläinen OPH, Linder B, Suvisaari J, Brosi C, Hennah W, Leppä V, Torniainen M et al. ( 2013 ) . Deletion of TOP3β, a component of FMRP-containing mRNPs, contributes to neurodevelopmental disorders . Nature Neuroscience vol. 16 , ( 9 ) 1228 - 1237 .

Pooley KA, Bojesen SE, Weischer M, Nielsen SF, Thompson D, Al Olama AA, Michailidou K, Tyrer JP et al. ( 2013 ) . A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk . Human Molecular Genetics vol. 22 , ( 24 ) 5056 - 5064 .

Khawaja AP, Chan MPY, Garway-Heath DF, Broadway DC, Luben R, Sherwin JC, Hayat S, Khaw K-T et al. ( 2013 ) . Associations With Retinal Nerve Fiber Layer Measures in the EPIC-Norfolk Eye StudyRNFL Measures in the EPIC-Norfolk Eye Study . Investigative Ophthalmology & Visual Science vol. 54 , ( 7 ) 5028 - 5034 .

Hu Y-J, Berndt SI, Gustafsson S, Ganna A, Consortium GIOAT, Berndt SI, Gustafsson S, Mägi R et al. ( 2013 ) . Meta-analysis of Gene-Level Associations for Rare Variants Based on Single-Variant Statistics . American Journal of Human Genetics vol. 93 , ( 2 ) 236 - 248 .

Day AC, Khawaja AP, Peto T, Hayat S, Luben R, Broadway DC, Khaw K-T, Foster PJ ( 2013 ) . The small eye phenotype in the EPIC-Norfolk eye study: prevalence and visual impairment in microphthalmos and nanophthalmos . BMJ Open vol. 3 , ( 7 )

Ahmadi-Abhari S, Luben RN, Powell N, Bhaniani A, Chowdhury R, Wareham NJ, Forouhi NG, Khaw K-T ( 2013 ) . Dietary intake of carbohydrates and risk of type 2 diabetes: the European Prospective Investigation into Cancer-Norfolk study . British Journal Of Nutrition vol. 111 , ( 2 ) 342 - 352 .

Strange A, Bellenguez C, Sim X, Luben R, Hysi PG, Ramdas WD, van Koolwijk LME, Freeman C et al. ( 2013 ) . Genome-wide association study of intraocular pressure identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locus . Human Molecular Genetics vol. 22 , ( 22 ) 4653 - 4660 .

Ahmadi-Abhari S, Luben RN, Wareham NJ, Khaw K-T ( 2013 ) . Seventeen year risk of all-cause and cause-specific mortality associated with C-reactive protein, fibrinogen and leukocyte count in men and women: the EPIC-Norfolk study . European Journal of Epidemiology vol. 28 , ( 7 ) 541 - 550 .

( 2013 ) . Erratum . American Journal of Clinical Nutrition vol. 98 , ( 1 ) 246 - 258 .

Ahmadi‐Abhari S, Luben RN, Wareham NJ, Khaw K ( 2013 ) . Distribution and determinants of C‐reactive protein in the older adult population: European Prospective Investigation into Cancer‐Norfolk study . European Journal of Clinical Investigation vol. 43 , ( 9 ) 899 - 911 .

Hayat SA, Luben R, Keevil VL, Moore S, Dalzell N, Bhaniani A, Khawaja AP, Foster P et al. ( 2013 ) . Cohort Profile: A prospective cohort study of objective physical and cognitive capability and visual health in an ageing population of men and women in Norfolk (EPIC-Norfolk 3) . International Journal of Epidemiology vol. 43 , ( 4 ) 1063 - 1072 .

Ganesh SK, Tragante V, Guo W, Guo Y, Lanktree MB, Smith EN, Johnson T, Castillo BA et al. ( 2013 ) . Loci influencing blood pressure identified using a cardiovascular gene-centric array . Human Molecular Genetics vol. 22 , ( 16 ) 3394 - 3395 .

Lentjes MAH, Welch AA, Luben RN, Khaw K-T ( 2013 ) . Differences in Dietary Supplement Use and Secular and Seasonal Trends Assessed Using Three Different Instruments in the EPIC-Norfolk Population Study . Journal of Dietary Supplements vol. 10 , ( 2 ) 142 - 151 .

van der Linde RM, Mavaddat N, Luben R, Brayne C, Simmons RK, Khaw KT, Kinmonth AL ( 2013 ) . Self-Rated Health and Cardiovascular Disease Incidence: Results from a Longitudinal Population-Based Cohort in Norfolk, UK . PLOS ONE vol. 8 , ( 6 )

Den Hoed M, Eijgelsheim M, Esko T, Brundel BJJM, Peal DS, Evans DM, Nolte IM, Segrè AV et al. ( 2013 ) . Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders . Nature Genetics vol. 45 , ( 6 ) 621 - 631 .

Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, Kilpeläinen TO, Esko T et al. ( 2013 ) . Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits . PLoS Genetics vol. 9 , ( 6 )

Pfister R, Michels G, Wilfred J, Luben R, Wareham NJ, Khaw K-T ( 2013 ) . Does ICD-10 hospital discharge code I50 identify people with heart failure? A validation study within the EPIC-Norfolk study . International Journal of Cardiology vol. 168 , ( 4 ) 4413 - 4414 .

Ahmadi-Abhari S, Luben RN, Wareham NJ, Khaw K-T ( 2013 ) . C-reactive protein and fracture risk: European Prospective Investigation into Cancer Norfolk Study . Bone vol. 56 , ( 1 ) 67 - 72 .

Wainwright NW, Levy S, Pico J, Luben RN, Surtees PG, Khaw K-T ( 2013 ) . Social Adversity Experience and Blood Pressure Control Following Antihypertensive Medication Use in a Community Sample of Older Adults . International Journal of Behavioral Medicine vol. 21 , ( 3 ) 456 - 463 .

Munroe PB, Barnes MR, Caulfield MJ ( 2013 ) . Advances in blood pressure genomics . Circ Res vol. 112 , ( 10 ) 1365 - 1379 .

Voight BF, Kang HM, Ding J, Palmer CD, Sidore C, Chines PS, Burtt NLP, Fuchsberger C et al. ( 2013 ) . Correction: The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits . PLOS Genetics vol. 9 , ( 4 )

CRAMER JD, GAETANO T, GRAY JP, GROBLER P, LORENZ JG, FREIMER NB, SCHMITT CA, TURNER TR ( 2013 ) . Variation in Scrotal Color Among Widely Distributed Vervet Monkey Populations (Chlorocebus Aethiops Pygerythrus and Chlorocebus Aethiops Sabaeus) . American Journal of Primatology vol. 75 , ( 7 ) 752 - 762 .

Huertas-Vazquez A, Nelson CP, Guo X, Reinier K, Uy-Evanado A, Teodorescu C, Ayala J, Jerger K et al. ( 2013 ) . Novel Loci Associated with Increased Risk of Sudden Cardiac Death in the Context of Coronary Artery Disease . PLOS ONE vol. 8 , ( 4 )

Michailidou K, Hall P, Gonzalez-Neira A, Ghoussaini M, Dennis J, Milne RL, Schmidt MK, Chang-Claude J et al. ( 2013 ) . Large-scale genotyping identifies 41 new loci associated with breast cancer risk . Nature Genetics vol. 45 , ( 4 ) 353 - 361 .

Bojesen SE, Pooley KA, Johnatty SE, Beesley J, Michailidou K, Tyrer JP, Edwards SL, Pickett HA et al. ( 2013 ) . Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer . Nature Genetics vol. 45 , ( 4 ) 371 - 384 .

Nag A, Bochukova EG, Kremeyer B, Campbell DD, Muller H, Valencia-Duarte AV, Cardona J, Rivas IC et al. ( 2013 ) . CNV Analysis in Tourette Syndrome Implicates Large Genomic Rearrangements in COL8A1 and NRXN1 . PLOS ONE vol. 8 , ( 3 )

Khawaja AP, Chan MPY, Hayat S, Broadway DC, Luben R, Garway-Heath DF, Sherwin JC, Yip JLY et al. ( 2013 ) . The EPIC-Norfolk Eye Study: rationale, methods and a cross-sectional analysis of visual impairment in a population-based cohort . BMJ Open vol. 3 , ( 3 )

Lahiri M, Luben RN, Morgan C, Bunn DK, Marshall T, Lunt M, Verstappen SMM, Symmons DPM et al. ( 2013 ) . Using lifestyle factors to identify individuals at higher risk of inflammatory polyarthritis (results from the European Prospective Investigation of Cancer-Norfolk and the Norfolk Arthritis Register—the EPIC-2-NOAR Study) . Annals of the Rheumatic Diseases vol. 73 , ( 1 )

Day AC, Luben R, Khawaja AP, Low S, Hayat S, Dalzell N, Wareham NJ, Khaw K-T et al. ( 2013 ) . Genotype–phenotype analysis of SNPs associated with primary angle closure glaucoma (rs1015213, rs3753841 and rs11024102) and ocular biometry in the EPIC-Norfolk Eye Study . British Journal of Ophthalmology vol. 97 , ( 6 )

May AM, Barnes DR, Forouhi NG, Luben R, Khaw K, Wareham NJ, Peeters PHM, Sharp SJ ( 2013 ) . Prediction of measured weight from self‐reported weight was not improved after stratification by body mass index . Obesity vol. 21 , ( 1 ) e137 - e142 .

Gkrania-Klotsas E, Langenberg C, Sharp SJ, Luben R, Khaw K-T, Wareham NJ ( 2013 ) . Seropositivity and Higher Immunoglobulin G Antibody Levels Against Cytomegalovirus Are Associated With Mortality in the Population-Based European Prospective Investigation of Cancer–Norfolk Cohort . Clinical Infectious Diseases vol. 56 , ( 10 ) 1421 - 1427 .

van Scheltinga AFT, Bakker SC, van Haren NEM, Derks EM, Buizer-Voskamp JE, Cahn W, Ripke S, Ophoff RA et al. ( 2013 ) . Schizophrenia genetic variants are not associated with intelligence . Psychological Medicine vol. 43 , ( 12 ) 2563 - 2570 .

Vimaleswaran KS, Berry DJ, Lu C, Tikkanen E, Pilz S, Hiraki LT, Cooper JD, Dastani Z et al. ( 2013 ) . Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts . PLOS Medicine vol. 10 , ( 2 )

Köttgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark C, Pistis G, Ruggiero D et al. ( 2013 ) . Genome-wide association analyses identify 18 new loci associated with serum urate concentrations . Nature Genetics vol. 45 , ( 2 ) 145 - 154 .

Ma D, Jasinska A, Kristoff J, Grobler JP, Turner T, Jung Y, Schmitt C, Raehtz K et al. ( 2013 ) . SIVagm Infection in Wild African Green Monkeys from South Africa: Epidemiology, Natural History, and Evolutionary Considerations . PLOS Pathogens vol. 9 , ( 1 )

Chan SSM, Luben R, Olsen A, Tjonneland A, Kaaks R, Teucher B, Lindgren S, Grip O et al. ( 2013 ) . Body Mass Index and the Risk for Crohn's Disease and Ulcerative Colitis: Data From a European Prospective Cohort Study (The IBD in EPIC Study) . The American Journal of Gastroenterology vol. 108 , ( 4 )

Munroe PB, Johnson T ( 2013 ) . Chapter 44 Hypertension . Genomic and Personalized Medicine , Elsevier

Alvarez-Madrazo S, MacKenzie SM, Davies E, Fraser R, Lee W-K, Brown M, Caulfield MJ, Dominiczak AF et al. ( 2013 ) . Common Polymorphisms in the <i>CYP11B1</i> and <i>CYP11B2</i> Genes: Evidence for a Digenic Influence on Hypertension . HYPERTENSION vol. 61 , ( 1 ) 232 - + .

Verweij N, Mahmud H, Leach IM, de Boer RA, Brouwers FP, Yu H, Asselbergs FW, Struck J et al. ( 2013 ) . Genome-Wide Association Study on Plasma Levels of Midregional-Proadrenomedullin and C-Terminal-Pro-Endothelin-1 . HYPERTENSION vol. 61 , ( 3 ) 602 - + .

Koettgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark C, Pistis G, Ruggiero D et al. ( 2013 ) . Genome-wide association analyses identify 18 new loci associated with serum urate concentrations . NATURE GENETICS vol. 45 , ( 2 ) 145 - 154 .

Berndt SI, Gustafsson S, Maegi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL et al. ( 2013 ) . Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture . NATURE GENETICS vol. 45 , ( 5 ) 501 - U69 .

Ganesh SK, Tragante V, Guo W, Guo Y, Lanktree MB, Smith EN, Johnson T, Castillo BA et al. ( 2013 ) . Loci influencing blood pressure identified using a cardiovascular gene-centric array . HUMAN MOLECULAR GENETICS vol. 22 , ( 8 ) 1663 - 1678 .

O'Seaghdha CM, Wu H, Yang Q, Kapur K, Guessous I, Zuber AM, Koettgen A, Stoudmann C et al. ( 2013 ) . Meta-Analysis of Genome-Wide Association Studies Identifies Six New Loci for Serum Calcium Concentrations . PLOS GENETICS vol. 9 , ( 9 ) Article ARTN e1003796 ,

Jasinska AJ, Schmitt CA, Service SK, Cantor RM, Dewar K, Jentsch JD, Kaplan JR, Turner TR et al. ( 2013 ) . Systems Biology of the Vervet Monkey . ILAR Journal vol. 54 , ( 2 ) 122 - 143 .

Munroe PB, Johnson T ( 2012 ) . Hypertension . Genomic and Personalized Medicine ,

Eyre S, Bowes J, Diogo D, Lee A, Barton A, Martin P, Zhernakova A, Stahl E et al. ( 2012 ) . High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis . Nature Genetics vol. 44 , ( 12 ) 1336 - 1340 .

Reich D, Patterson N, Campbell D, Tandon A, Mazieres S, Ray N, Parra MV, Rojas W et al. ( 2012 ) . Correction: Corrigendum: Reconstructing Native American population history . Nature vol. 491 , ( 7423 ) 288 - 288 .

Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee JC, Philip Schumm L et al. ( 2012 ) . Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease . Nature vol. 491 , ( 7422 ) 119 - 124 .

Verstappen SMM, Lunt M, Luben RN, Chipping J, Marshall T, Khaw K-T, Wareham N, Dixon WG et al. ( 2012 ) . Demographic and disease-related predictors of abnormal lung function in patients with established inflammatory polyarthritis and a comparison with the general population . Annals of the Rheumatic Diseases vol. 72 , ( 9 )

Gurdasani D, Sjouke B, Tsimikas S, Hovingh GK, Luben RN, Wainwright NWJ, Pomilla C, Wareham NJ et al. ( 2012 ) . Lipoprotein(a) and Risk of Coronary, Cerebrovascular, and Peripheral Artery Disease . Arteriosclerosis Thrombosis and Vascular Biology vol. 32 , ( 12 ) 3058 - 3065 .

Gkrania-Klotsas E, Langenberg C, Sharp SJ, Luben R, Khaw K-T, Wareham NJ ( 2012 ) . Higher Immunoglobulin G Antibody Levels Against Cytomegalovirus Are Associated With Incident Ischemic Heart Disease in the Population-Based EPIC-Norfolk Cohort . The Journal of Infectious Diseases vol. 206 , ( 12 ) 1897 - 1903 .

Chen K, Budman CL, Herrera LD, Witkin JE, Weiss NT, Lowe TL, Freimer NB, Reus VI et al. ( 2012 ) . Prevalence and clinical correlates of explosive outbursts in Tourette Syndrome . Psychiatry Research vol. 205 , ( 3 ) 269 - 275 .

van Scheltinga AFT, Bakker SC, van Haren NEM, Derks EM, Buizer-Voskamp JE, Boos HBM, Cahn W, Pol HEH et al. ( 2012 ) . Genetic Schizophrenia Risk Variants Jointly Modulate Total Brain and White Matter Volume . Biological Psychiatry vol. 73 , ( 6 ) 525 - 531 .

Gay LJ, Mitrou PN, Keen J, Bowman R, Naguib A, Cooke J, Kuhnle GG, Burns PA et al. ( 2012 ) . Dietary, lifestyle and clinicopathological factors associated with APC mutations and promoter methylation in colorectal cancers from the EPIC‐Norfolk study . The Journal of Pathology vol. 228 , ( 3 ) 405 - 415 .

Guo Y, Lanktree MB, Taylor KC, Hakonarson H, Lange LA, Keating BJ, Consortium TIKSAB ( 2012 ) . Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals . Human Molecular Genetics vol. 22 , ( 1 ) 184 - 201 .

Canoy D, Wareham N, Luben R, Welch A, Bingham S, Day N, Khaw K ( 2012 ) . Cigarette Smoking and Fat Distribution in 21, 828 British Men and Women: A Population‐based Study . Obesity vol. 13 , ( 8 ) 1466 - 1475 .

Myint PK, Welch AA, Luben RN, Wainwright NWJ, Surtees PG, Bingham SA, Wareham NJ, Smith RD et al. ( 2012 ) . Obesity Indices and Self‐Reported Functional Health in Men and Women in the EPIC‐Norfolk . Obesity vol. 14 , ( 5 ) 884 - 893 .

Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, MäGi R, Strawbridge RJ et al. ( 2012 ) . Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways . Nature Genetics vol. 44 , ( 9 ) 991 - 1005 .

Cooper JD, Simmonds MJ, Walker NM, Burren O, Brand OJ, Guo H, Wallace C, Stevens H et al. ( 2012 ) . Seven newly identified loci for autoimmune thyroid disease . Human Molecular Genetics vol. 21 , ( 23 ) 5202 - 5208 .

Miettunen J, Isohanni M, Paunio T, Freimer N, Taanila A, Ekelund J, Järvelin M-R, Joukamaa M et al. ( 2012 ) . Predicting Depression with Psychopathology and Temperament Traits: The Northern Finland 1966 Birth Cohort . Depression Research and Treatment vol. 2012 , ( 1 )

Scharf JM, Yu D, Mathews CA, Neale BM, Stewart SE, Fagerness JA, Evans P, Gamazon E et al. ( 2012 ) . Genome-wide association study of Tourette's syndrome . Molecular Psychiatry vol. 18 , ( 6 ) 721 - 728 .

Bouloux PG, Kirk J, Munroe P, Duke V, Meindl A, Hilson A, Grant D, Carter N et al. ( 2012 ) . Deletion analysis maps ocular albinism proximal to the steroid sulphatase locus . Clinical Genetics vol. 43 , ( 4 ) 169 - 173 .

Pye SR, Marshall T, Gaffney K, Luben R, Khaw K-T, Silman AJ, Symmons DP, O’Neill TW ( 2012 ) . Influence of Inflammatory Polyarthritis on Quantitative Heel Ultrasound Measurements . BMC Musculoskeletal Disorders vol. 13 , ( 1 )

Banim PJR, Luben R, McTaggart A, Welch A, Wareham N, Khaw K-T, Hart AR ( 2012 ) . Dietary antioxidants and the aetiology of pancreatic cancer: a cohort study using data from food diaries and biomarkers . Gut vol. 62 , ( 10 )

McQuillan R, Eklund N, Pirastu N, Kuningas M, McEvoy BP, Esko T, Corre T, Davies G et al. ( 2012 ) . Evidence of Inbreeding Depression on Human Height . PLOS Genetics vol. 8 , ( 7 )

Gencer B, Collet T-H, Virgini V, Bauer DC, Gussekloo J, Cappola AR, Nanchen D, Elzen WPJD et al. ( 2012 ) . Subclinical Thyroid Dysfunction and the Risk of Heart Failure Events . Circulation vol. 126 , ( 9 ) 1040 - 1049 .

Congdon E, Service S, Wessman J, Seppänen JK, Schönauer S, Miettunen J, Turunen H, Koiranen M et al. ( 2012 ) . Early Environment and Neurobehavioral Development Predict Adult Temperament Clusters . PLOS ONE vol. 7 , ( 7 )

Wessman J, Schönauer S, Miettunen J, Turunen H, Parviainen P, Seppänen JK, Congdon E, Service S et al. ( 2012 ) . Temperament Clusters in a Normal Population: Implications for Health and Disease . PLOS ONE vol. 7 , ( 7 )

Okada Y, Sim X, Go MJ, Wu J-Y, Gu D, Takeuchi F, Takahashi A, Maeda S et al. ( 2012 ) . Meta-analysis identifies multiple loci associated with kidney function–related traits in east Asian populations . Nature Genetics vol. 44 , ( 8 ) 904 - 909 .

Reich D, Patterson N, Campbell D, Tandon A, Mazieres S, Ray N, Parra MV, Rojas W et al. ( 2012 ) . Reconstructing Native American population history . Nature vol. 488 , ( 7411 ) 370 - 374 .

Vachon CM, Scott CG, Fasching PA, Hall P, Tamimi RM, Li J, Stone J, Apicella C et al. ( 2012 ) . Common Breast Cancer Susceptibility Variants in LSP1 and RAD51L1 Are Associated with Mammographic Density Measures that Predict Breast Cancer Risk . Cancer Epidemiology Biomarkers & Prevention vol. 21 , ( 7 ) 1156 - 1166 .

Khaw K-T, Friesen MD, Riboli E, Luben R, Wareham N ( 2012 ) . Plasma Phospholipid Fatty Acid Concentration and Incident Coronary Heart Disease in Men and Women: The EPIC-Norfolk Prospective Study . PLOS Medicine vol. 9 , ( 7 )

Derks EM, Vorstman JAS, Ripke S, Kahn RS, Ophoff RA ( 2012 ) . Investigation of the Genetic Association between Quantitative Measures of Psychosis and Schizophrenia: A Polygenic Risk Score Analysis . PLOS ONE vol. 7 , ( 6 )

Leng Y, Wainwright NWJ, Hayat S, Stephan BCM, Matthews FE, Luben R, Surtees PG, Khaw K-T et al. ( 2012 ) . The association between social stress and global cognitive function in a population-based study: the European Prospective Investigation into Cancer (EPIC)-Norfolk study . Psychological Medicine vol. 43 , ( 3 ) 655 - 666 .

Lanktree MB, Guo Y, Murtaza M, Glessner JT, Bailey SD, Onland-Moret NC, Lettre G, Ongen H et al. ( 2012 ) . Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height . American Journal of Human Genetics vol. 90 , ( 6 ) 1116 - 1117 .

Collet T-H, Gussekloo J, Bauer DC, Elzen WPJD, Cappola AR, Balmer P, Iervasi G, Åsvold BO et al. ( 2012 ) . Subclinical Hyperthyroidism and the Risk of Coronary Heart Disease and Mortality . JAMA Internal Medicine vol. 172 , ( 10 ) 799 - 809 .

Karayiorgou M, Flint J, Gogos JA, Malenka RC ( 2012 ) . The best of times, the worst of times for psychiatric disease . Nature Neuroscience vol. 15 , ( 6 ) 811 - 812 .

Levine AJ, Service S, Miller EN, Reynolds SM, Singer EJ, Shapshak P, Martin EM, Sacktor N et al. ( 2012 ) . Genome‐wide association study of neurocognitive impairment and dementia in HIV‐infected adults . American Journal of Medical Genetics Part B Neuropsychiatric Genetics vol. 159B , ( 6 ) 669 - 683 .

Service SK, Verweij KJH, Lahti J, Congdon E, Ekelund J, Hintsanen M, Räikkönen K, Lehtimäki T et al. ( 2012 ) . A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales . Translational Psychiatry vol. 2 , ( 5 ) e116 - e116 .

Cooper AJ, Sharp SJ, Lentjes MAH, Luben RN, Khaw K-T, Wareham NJ, Forouhi NG ( 2012 ) . A Prospective Study of the Association Between Quantity and Variety of Fruit and Vegetable Intake and Incident Type 2 Diabetes . Diabetes Care vol. 35 , ( 6 ) 1293 - 1300 .

Jasinska AJ, Lin MK, Service S, Choi O-W, DeYoung J, Grujic O, Kong S-Y, Jung Y et al. ( 2012 ) . A non-human primate system for large-scale genetic studies of complex traits . Human Molecular Genetics vol. 21 , ( 15 ) 3307 - 3316 .

Sherwin JC, Khawaja AP, Broadway D, Luben R, Hayat S, Dalzell N, Wareham NJ, Khaw K-T et al. ( 2012 ) . Uncorrected refractive error in older British adults: the EPIC-Norfolk Eye Study . British Journal of Ophthalmology vol. 96 , ( 7 )

Stevens KN, Lindstrom S, Scott CG, Thompson D, Sellers TA, Wang X, Wang A, Atkinson E et al. ( 2012 ) . Identification of a novel percent mammographic density locus at 12q24 . Human Molecular Genetics vol. 21 , ( 14 ) 3299 - 3305 .

Golubic R, Ekelund U, Wijndaele K, Luben R, Khaw K-T, Wareham NJ, Brage S ( 2012 ) . Rate of weight gain predicts change in physical activity levels: a longitudinal analysis of the EPIC-Norfolk cohort . International Journal of Obesity vol. 37 , ( 3 ) 404 - 409 .

Forouhi NG, Ye Z, Rickard AP, Khaw KT, Luben R, Langenberg C, Wareham NJ ( 2012 ) . Circulating 25-hydroxyvitamin D concentration and the risk of type 2 diabetes: results from the European Prospective Investigation into Cancer (EPIC)-Norfolk cohort and updated meta-analysis of prospective studies . Diabetologia vol. 55 , ( 8 ) 2173 - 2182 .

Estrada K, Styrkarsdottir U, Evangelou E, Hsu Y-H, Duncan EL, Ntzani EE, Oei L, Albagha OME et al. ( 2012 ) . Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture . Nature Genetics vol. 44 , ( 5 ) 491 - 501 .

Stein JL, Medland SE, Vasquez AA, Hibar DP, Senstad RE, Winkler AM, Toro R, Appel K et al. ( 2012 ) . Identification of common variants associated with human hippocampal and intracranial volumes . Nature Genetics vol. 44 , ( 5 ) 552 - 561 .

Keller MC, Simonson MA, Ripke S, Neale BM, Gejman PV, Howrigan DP, Lee SH, Lencz T et al. ( 2012 ) . Runs of Homozygosity Implicate Autozygosity as a Schizophrenia Risk Factor . PLOS Genetics vol. 8 , ( 4 )

Saxena R, Elbers CC, Guo Y, Peter I, Gaunt TR, Mega JL, Lanktree MB, Tare A et al. ( 2012 ) . Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci . American Journal of Human Genetics vol. 90 , ( 4 )

Dastani Z, Hivert M-F, Timpson N, Perry JRB, Yuan X, Scott RA, Henneman P, Heid IM et al. ( 2012 ) . Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals . PLOS Genetics vol. 8 , ( 3 )

Varghese JS, Thompson DJ, Michailidou K, Lindström S, Turnbull C, Brown J, Leyland J, Warren RML et al. ( 2012 ) . Mammographic Breast Density and Breast Cancer: Evidence of a Shared Genetic Basis . Cancer Research vol. 72 , ( 6 ) 1478 - 1484 .

Yoneyama S, Taylor KC, Fox CS, Keating BJ, Gong Y, Reiner AP, Shen H, Gorski M et al. ( 2012 ) . Abstract MP068: Association Study of SNPs and measures of adiposity among 51990 European and European American Identifies Three Novel Loci . Circulation vol. 125 , ( suppl_10 )

Xue F, Li S, Luan J, Yuan Z, Luben RN, Khaw K-T, Wareham NJ, Loos RJF et al. ( 2012 ) . A Latent Variable Partial Least Squares Path Modeling Approach to Regional Association and Polygenic Effect with Applications to a Human Obesity Study . PLOS ONE vol. 7 , ( 2 )

Melzer D, Osborne NJ, Henley WE, Cipelli R, Young A, Money C, McCormack P, Luben R et al. ( 2012 ) . Urinary Bisphenol A Concentration and Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women . Circulation vol. 125 , ( 12 ) 1482 - 1490 .

Angelakopoulou A, Shah T, Sofat R, Shah S, Berry DJ, Cooper J, Palmen J, Tzoulaki I et al. ( 2012 ) . Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration . Eur Heart J vol. 33 , ( 3 ) 393 - 407 .

Salvi E, Kutalik Z, Glorioso N, Benaglio P, Frau F, Kuznetsova T, Arima H, Hoggart C et al. ( 2012 ) . Genomewide association study using a high-density single nucleotide polymorphism array and case-control design identifies a novel essential hypertension susceptibility locus in the promoter region of endothelial NO synthase . Hypertension vol. 59 , ( 2 ) 248 - 255 .

Kettunen J, Tukiainen T, Sarin A-P, Ortega-Alonso A, Tikkanen E, Lyytikäinen L-P, Kangas AJ, Soininen P et al. ( 2012 ) . Genome-wide association study identifies multiple loci influencing human serum metabolite levels . Nature Genetics vol. 44 , ( 3 ) 269 - 276 .

Gkrania-Klotsas E, Langenberg C, Tauriainen S, Sharp SJ, Luben R, Forouhi NG, Khaw KT, Hyöty H et al. ( 2012 ) . The association between prior infection with five serotypes of Coxsackievirus B and incident type 2 diabetes mellitus in the EPIC-Norfolk study . Diabetologia vol. 55 , ( 4 ) 967 - 970 .

Brand JS, van der Schouw YT, Dowsett M, Folkerd E, Luben RN, Wareham NJ, Khaw K-T ( 2012 ) . Testosterone, SHBG and differential white blood cell count in middle-aged and older men . Maturitas vol. 71 , ( 3 ) 274 - 278 .

Jamshidi Y, Nolte IM, Dalageorgou C, Zheng D, Johnson T, Bastiaenen R, Ruddy S, Talbott D et al. ( 2012 ) . Common Variation in the <i>NOS1AP</i> Gene Is Associated With Drug-Induced QT Prolongation and Ventricular Arrhythmia . JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY vol. 60 , ( 9 ) 841 - 850 .

Surendran P, Vangjeli C, McCarthy N, Thom S, Sever P, O'Brien E, Poulter N, Mayet J et al. ( 2012 ) . Genome-wide association analysis identifies the MTHFR-CLCN6-NPPA-NPPB gene cluster as an important influence on BNP levels-implications for the use of BNP levels in the diagnosis and therapeutic monitoring of heart failure-an ASCOT sub study . JOURNAL OF HUMAN HYPERTENSION vol. 26 , ( 10 ) 620 - 620 .

Addison S, Sebire NJ, Taylor AM, Abrams D, Peebless D, Mein C, Munroe PB, Thayyil S ( 2012 ) . High quality genomic DNA extraction from postmortem fetal tissue . JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE vol. 25 , ( 11 ) 2467 - 2469 .

Friese RS, Ye C, Nievergelt CM, Schork AJ, Mahapatra NR, Rao F, Napolitan PS, Waalen J et al. ( 2012 ) . Integrated Computational and Experimental Analysis of the Neuroendocrine Transcriptome in Genetic Hypertension Identifies Novel Control Points for the Cardiometabolic Syndrome . CIRCULATION-CARDIOVASCULAR GENETICS vol. 5 , ( 4 ) 430 - 440 .

Saxena R, Elbers CC, Guo Y, Peter I, Gaunt TR, Mega JL, Lanktree MB, Tare A et al. ( 2012 ) . Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci . AMERICAN JOURNAL OF HUMAN GENETICS vol. 90 , ( 3 ) 410 - 425 .

Asselbergs FW, Guo Y, van Iperen EPA, Sivapalaratnam S, Tragante V, Lanktree MB, Lange LA, Almoguera B et al. ( 2012 ) . Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci . AMERICAN JOURNAL OF HUMAN GENETICS vol. 91 , ( 5 ) 823 - 838 .

Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, Mägi R, Strawbridge RJ et al. ( 2012 ) . Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways . Nature Genetics

Voight BF, Kang HM, Ding J, Palmer CD, Sidore C, Chines PS, Burtt NP, Fuchsberger C et al. ( 2012 ) . The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits . PLOS GENETICS vol. 8 , ( 8 ) Article ARTN e1002793 ,

Fears SC, Scheibel K, Abaryan Z, Lee C, Service SK, Jorgensen MJ, Fairbanks LA, Cantor RM et al. ( 2011 ) . Anatomic Brain Asymmetry in Vervet Monkeys . PLOS ONE vol. 6 , ( 12 )

Knaze V, Zamora-Ros R, Luján-Barroso L, Romieu I, Scalbert A, Slimani N, Riboli E, van Rossum CTM et al. ( 2011 ) . Intake estimation of total and individual flavan-3-ols, proanthocyanidins and theaflavins, their food sources and determinants in the European Prospective Investigation into Cancer and Nutrition (EPIC) study . British Journal Of Nutrition vol. 108 , ( 6 ) 1095 - 1108 .

Pfister R, Sharp SJ, Luben R, Wareham NJ, Khaw K-T ( 2011 ) . Differential white blood cell count and incident heart failure in men and women in the EPIC-Norfolk study . European Heart Journal vol. 33 , ( 4 ) 523 - 530 .

Johnson T, Gaunt TR, Newhouse SJ, Padmanabhan S, Tomaszewski M, Kumari M, Morris RW, Tzoulaki I et al. ( 2011 ) . Blood pressure loci identified with a gene-centric array . Am J Hum Genet vol. 89 , ( 6 ) 688 - 700 .

Surtees PG, Wainwright NWJ, Pooley KA, Luben RN, Khaw K-T, Easton DF, Dunning AM ( 2011 ) . Educational attainment and mean leukocyte telomere length in women in the European Prospective Investigation into Cancer (EPIC)-Norfolk population study . Brain Behavior and Immunity vol. 26 , ( 3 ) 414 - 418 .

Shah S, Nelson CP, Gaunt TR, van der Harst P, Barnes T, Braund PS, Lawlor DA, Casas J-P et al. ( 2011 ) . Four genetic loci influencing electrocardiographic indices of left ventricular hypertrophy . Circ Cardiovasc Genet vol. 4 , ( 6 ) 626 - 635 .

Freitas RN, Luben R, Wareham NJ, Khaw K-T ( 2011 ) . Relationship between plasma fibrinogen and fiber intake in the EPIC-Norfolk cohort . European Journal of Clinical Nutrition vol. 66 , ( 4 ) 443 - 451 .

Bown MJ, Jones GT, Harrison SC, Wright BJ, Bumpstead S, Baas AF, Gretarsdottir S, Badger SA et al. ( 2011 ) . Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1 . American Journal of Human Genetics vol. 89 , ( 5 ) 619 - 627 .

Ward HA, Keogh R, Lentjes M, Luben RN, Wareham NJ, Khaw K-T ( 2011 ) . Fibre intake in relation to serum total cholesterol levels and CHD risk: a comparison of dietary assessment methods . European Journal of Clinical Nutrition vol. 66 , ( 3 ) 296 - 304 .

Chambers JC, Zhang WH, Sehmi J, Li XZ, Wass MN, Van der Harst P, Holm H, Sanna S et al. ( 2011 ) . Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma . NAT GENET vol. 43 , ( 11 ) 1131 - U129 .

Addison S, Sebire NJ, Judge-Kronis L, Taylor AM, Abrams D, Scott R, Robertson NJ, Peebles D et al. ( 2011 ) . Genomic Deoxyribonucleic Acid Extraction from Post Mortem Fetal Tissue . Pediatric Research vol. 70 , ( Suppl 5 ) 406 - 406 .

Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, Thorleifsson G, Zillikens MC et al. ( 2011 ) . Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution . Nature Genetics vol. 43 , ( 11 ) 1164 - 1164 .

Pfister R, Sharp S, Luben R, Welsh P, Barroso I, Salomaa V, Meirhaeghe A, Khaw K-T et al. ( 2011 ) . Mendelian Randomization Study of B-Type Natriuretic Peptide and Type 2 Diabetes: Evidence of Causal Association from Population Studies . PLOS Medicine vol. 8 , ( 10 )

Surakka I, Isaacs A, Karssen LC, Laurila P-PP, Middelberg RPS, Tikkanen E, Ried JS, Lamina C et al. ( 2011 ) . A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol . PLOS Genetics vol. 7 , ( 10 )

Foster PJ, Broadway DC, Garway-Heath DF, Yip JLY, Luben R, Hayat S, Dalzell N, Wareham NJ et al. ( 2011 ) . Intraocular Pressure and Corneal Biomechanics in an Adult British Population: The EPIC-Norfolk Eye Study . Investigative Ophthalmology & Visual Science vol. 52 , ( 11 ) 8179 - 8185 .

Yip JLY, Broadway DC, Luben R, Garway-Heath DF, Hayat S, Dalzell N, Lee PS, Bhaniani A et al. ( 2011 ) . Physical Activity and Ocular Perfusion Pressure: The EPIC-Norfolk Eye Study . Investigative Ophthalmology & Visual Science vol. 52 , ( 11 ) 8186 - 8192 .

Wain LV, Verwoert GC, O'Reilly PF, Shi G, Johnson T, Munroe PB, Psaty BM, Caulfield MJ et al. ( 2011 ) . A large genome-wide association study of pulse pressure and mean arterial pressure reveals seven novel blood pressure LOCI . J HUM HYPERTENS vol. 25 , ( 10 ) 647 - 647 .

Dahm CC, Keogh RH, Lentjes MAH, Spencer EA, Key TJ, Greenwood DC, Cade JE, Burley VJ et al. ( 2011 ) . Erratum to “Intake of dietary fats and colorectal cancer risk: Prospective findings from the UK Dietary Cohort Consortium” [Cancer Epidemiol. 34 (2010) 562–567] . Cancer Epidemiology vol. 35 , ( 5 )

Wain LV, Verwoert GC, O'Reilly PF, Shi G, Johnson T, Johnson AD, Bochud M, Rice KM et al. ( 2011 ) . Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure . NAT GENET vol. 43 , ( 10 ) 1005 - U122 .

McCarthy N, Vangjeli C, Surendran P, Treumann A, Rooney C, Ho E, Sever P, Thom S et al. ( 2011 ) . PPARGC1 beta is a genetic determinant of the cardiovascular risk factor, Thromboxane A2-an Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) sub-study . J HUM HYPERTENS vol. 25 , ( 10 ) 625 - 625 .

Ehret G, Munroe PB, Rice K, Bochud M, Johnson A, Chasman D, Vernon-Smith A, Psaty B et al. ( 2011 ) . Sixteen novel loci influence blood pressure and cardiovascular risk . J HUM HYPERTENS vol. 25 , ( 10 ) 635 - 636 .

( 2011 ) . Genome-wide association study identifies five new schizophrenia loci . Nature Genetics vol. 43 , ( 10 ) 969 - 976 .

Strawbridge RJ, Dupuis J, Prokopenko I, Barker A, Ahlqvist E, Rybin D, Petrie JR, Travers ME et al. ( 2011 ) . Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes . Diabetes vol. 60 , ( 10 ) 2624 - 2634 .

International Consortium for Blood Pressure Genome-Wide Association Studies, Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV et al. ( 2011 ) . Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk . Nature vol. 478 , ( 7367 ) 103 - 109 .

Moayyeri A, Luben RN, Wareham NJ, Khaw K ( 2011 ) . Body fat mass is a predictor of risk of osteoporotic fractures in women but not in men: a prospective population study . Journal of Internal Medicine vol. 271 , ( 5 ) 472 - 480 .

Ricketts SL, Rensing KL, Holly JM, Chen L, Young EH, Luben R, Ashford S, Song K et al. ( 2011 ) . Prospective study of insulin-like growth factor-I, insulinlike growth factor-binding protein 3, genetic variants in the IGF1 and IGFBP3 genes and risk of coronary artery disease . International Journal of Molecular Epidemiology and Genetics vol. 2 , ( 3 ) 261 - 285 .

Gay LJ, Arends MJ, Mitrou PN, Bowman R, Ibrahim AE, Happerfield L, Luben R, McTaggart A et al. ( 2011 ) . MLH1 Promoter Methylation, Diet, and Lifestyle Factors in Mismatch Repair Deficient Colorectal Cancer Patients From EPIC-Norfolk . Nutrition and Cancer vol. 63 , ( 7 ) 1000 - 1010 .

Key TJ, Appleby PN, Cairns BJ, Luben R, Dahm CC, Akbaraly T, Brunner EJ, Burley V et al. ( 2011 ) . Dietary fat and breast cancer: comparison of results from food diaries and food-frequency questionnaires in the UK Dietary Cohort Consortium . American Journal of Clinical Nutrition vol. 94 , ( 4 ) 1043 - 1052 .

Brand JS, Chan M-F, Dowsett M, Folkerd E, Wareham NJ, Luben RN, van der Schouw YT, Khaw K-T ( 2011 ) . Cigarette Smoking and Endogenous Sex Hormones in Postmenopausal Women . The Journal of Clinical Endocrinology & Metabolism vol. 96 , ( 10 ) 3184 - 3192 .

Banim PJR, Luben RN, Bulluck H, Sharp SJ, Wareham NJ, Khaw K-T, Hart AR ( 2011 ) . The aetiology of symptomatic gallstones quantification of the effects of obesity, alcohol and serum lipids on risk. Epidemiological and biomarker data from a UK prospective cohort study (EPIC-Norfolk) . European Journal of Gastroenterology & Hepatology vol. 23 , ( 8 ) 733 - 740 .

Chan SSM, Luben R, Bergmann MM, Boeing H, Olsen A, Tjonneland A, Overvad K, Kaaks R et al. ( 2011 ) . Aspirin in the aetiology of Crohn’s disease and ulcerative colitis: a European prospective cohort study . Alimentary Pharmacology & Therapeutics vol. 34 , ( 6 ) 649 - 655 .

Surtees PG, Wainwright NWJ, Pooley KA, Luben RN, Khaw K-T, Easton DF, Dunning AM ( 2011 ) . Life Stress, Emotional Health, and Mean Telomere Length in the European Prospective Investigation into Cancer (EPIC)-Norfolk Population Study . The Journals of Gerontology Series A vol. 66A , ( 11 ) 1152 - 1162 .

Wegmann D, Kessner DE, Veeramah KR, Mathias RA, Nicolae DL, Yanek LR, Sun YV, Torgerson DG et al. ( 2011 ) . Recombination rates in admixed individuals identified by ancestry-based inference . Nature Genetics vol. 43 , ( 9 ) 847 - 853 .

Myint PK, Luben RN, Wareham NJ, Khaw K-T ( 2011 ) . Association Between Plasma Vitamin C Concentrations and Blood Pressure in the European Prospective Investigation Into Cancer-Norfolk Population-Based Study . Hypertension vol. 58 , ( 3 ) 372 - 379 .

Spencer EA, Key TJ, Appleby PN, Dahm CC, Keogh RH, Fentiman IS, Akbaraly T, Brunner EJ et al. ( 2011 ) . Erratum to: Meat, poultry and fish and risk of colorectal cancer: pooled analysis of data from the UK dietary cohort consortium . Cancer Causes & Control vol. 22 , ( 9 )

Pfister R, Sharp SJ, Luben R, Wareham NJ, Khaw K-T ( 2011 ) . Plasma vitamin C predicts incident heart failure in men and women in European Prospective Investigation into Cancer and Nutrition–Norfolk prospective study . American Heart Journal vol. 162 , ( 2 ) 246 - 253 .

Putku M, Kepp K, Org E, Sõber S, Comas D, Viigimaa M, Veldre G, Juhanson P et al. ( 2011 ) . Novel polymorphic AluYb8 insertion in the WNK1 gene is associated with blood pressure variation in Europeans . Hum Mutat vol. 32 , ( 7 ) 806 - 814 .

Pfister R, Barnes D, Luben R, Forouhi NG, Bochud M, Khaw K-T, Wareham NJ, Langenberg C ( 2011 ) . No evidence for a causal link between uric acid and type 2 diabetes: a Mendelian randomisation approach . Diabetologia vol. 54 , ( 10 ) 2561 - 2569 .

Kilpeläinen TO, Zillikens MC, Stančákova A, Finucane FM, Ried JS, Langenberg C, Zhang W, Beckmann JS et al. ( 2011 ) . Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile . Nature Genetics vol. 43 , ( 8 ) 753 - 760 .

Pfister R, Barnes D, Luben RN, Khaw K-T, Wareham NJ, Langenberg C ( 2011 ) . Individual and cumulative effect of type 2 diabetes genetic susceptibility variants on risk of coronary heart disease . Diabetologia vol. 54 , ( 9 ) 2283 - 2287 .

Nyman E, Miettunen J, Freimer N, Joukamaa M, Mäki P, Ekelund J, Peltonen L, Järvelin M-R et al. ( 2011 ) . Impact of temperament on depression and anxiety symptoms and depressive disorder in a population-based birth cohort . Journal of Affective Disorders vol. 131 , ( 1-3 ) 393 - 397 .

Myint PK, Smith RD, Luben RN, Surtees PG, Wainwright NWJ, Wareham NJ, Khaw K-T ( 2011 ) . Lifestyle behaviours and quality-adjusted life years in middle and older age . Age and Ageing vol. 40 , ( 5 ) 589 - 595 .

Wijndaele K, Brage S, Besson H, Khaw K-T, Sharp SJ, Luben R, Bhaniani A, Wareham NJ et al. ( 2011 ) . Television Viewing and Incident Cardiovascular Disease: Prospective Associations and Mediation Analysis in the EPIC Norfolk Study . PLOS ONE vol. 6 , ( 5 )

Mumby HS, Elks CE, Li S, Sharp SJ, Khaw K-T, Luben RN, Wareham NJ, Loos RJF et al. ( 2011 ) . Mendelian Randomisation Study of Childhood BMI and Early Menarche . Journal of Obesity vol. 2011 , ( 1 )

Kuhnle GGC, Ward HA, Vogiatzoglou A, Luben RN, Mulligan A, Wareham NJ, Forouhi NG, Khaw K-T ( 2011 ) . Association between dietary phyto-oestrogens and bone density in men and postmenopausal women . British Journal Of Nutrition vol. 106 , ( 7 ) 1063 - 1069 .

Pfister R, Sharp SJ, Luben R, Khaw K-T, Wareham NJ ( 2011 ) . No evidence of an increased mortality risk associated with low levels of glycated haemoglobin in a non-diabetic UK population . Diabetologia vol. 54 , ( 8 ) 2025 - 2032 .

( 2011 ) . Correction for Schumann et al., Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption . Proceedings of the National Academy of Sciences of the United States of America vol. 108 , ( 22 ) 9316 - 9316 .

Johnson AD, Newton-Cheh C, Chasman DI, Ehret GB, Johnson T, Rose L, Rice K, Verwoert GC et al. ( 2011 ) . Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals . Hypertension vol. 57 , ( 5 ) 903 - 910 .

Pietiläinen OPH, Rehnström K, Jakkula E, Service SK, Congdon E, Tilgmann C, Hartikainen A-L, Taanila A et al. ( 2011 ) . Phenotype mining in CNV carriers from a population cohort † . Human Molecular Genetics vol. 20 , ( 13 ) 2686 - 2695 .

Naguib A, Cooke JC, Happerfield L, Kerr L, Gay LJ, Luben RN, Ball RY, Mitrou PN et al. ( 2011 ) . Alterations in PTEN and PIK3CA in colorectal cancers in the EPIC Norfolk study: associations with clinicopathological and dietary factors . BMC Cancer vol. 11 , ( 1 )

Brand JS, Wareham NJ, Dowsett M, Folkerd E, van der Schouw YT, Luben RN, Khaw K ( 2011 ) . Associations of endogenous testosterone and SHBG with glycated haemoglobin in middle‐aged and older men . Clinical Endocrinology vol. 74 , ( 5 ) 572 - 578 .

Schumann G, Coin LJ, Lourdusamy A, Charoen P, Berger KH, Stacey D, Desrivières S, Aliev FA et al. ( 2011 ) . Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption . Proceedings of the National Academy of Sciences of the United States of America vol. 108 , ( 17 ) 7119 - 7124 .

Miettunen J, Veijola J, Isohanni M, Paunio T, Freimer N, Jääskeläinen E, Taanila A, Ekelund J et al. ( 2011 ) . Identifying Schizophrenia and Other Psychoses With Psychological Scales in the General Population . The Journal of Nervous and Mental Disease vol. 199 , ( 4 ) 230 - 238 .

Loh YH, Jakszyn P, Luben RN, Mulligan AA, Mitrou PN, Khaw K-T ( 2011 ) . N-nitroso compounds and cancer incidence: the European Prospective Investigation into Cancer and Nutrition (EPIC)–Norfolk Study . American Journal of Clinical Nutrition vol. 93 , ( 5 ) 1053 - 1061 .

Park JY, Mitrou PN, Keogh RH, Luben RN, Wareham NJ, Khaw K-T ( 2011 ) . Self-reported and measured anthropometric data and risk of colorectal cancer in the EPIC–Norfolk study . International Journal of Obesity vol. 36 , ( 1 ) 107 - 118 .

Chamnan P, Simmons RK, Forouhi NG, Luben RN, Khaw K-T, Wareham NJ, Griffin SJ ( 2011 ) . Incidence of Type 2 Diabetes Using Proposed HbA1c Diagnostic Criteria in the European Prospective Investigation of Cancer–Norfolk Cohort Implications for preventive strategies . Diabetes Care vol. 34 , ( 4 ) 950 - 956 .

Matthews FE, Stephan BCM, Khaw K-T, Hayat S, Luben R, Bhaniani A, Moore S, Brayne C ( 2011 ) . Full-scale scores of the Mini Mental State Examination can be generated from an abbreviated version . Journal of Clinical Epidemiology vol. 64 , ( 9 ) 1005 - 1013 .

Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, Gudnason V, Eiriksdottir G et al. ( 2011 ) . Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits . PLOS Genetics vol. 7 , ( 3 )

Fox ER, Young JH, Li Y, Dreisbach AW, Keating BJ, Musani SK, Liu K, Morrison AC et al. ( 2011 ) . Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study . Human Molecular Genetics vol. 20 , ( 11 ) 2273 - 2284 .

Dehghan A, Dupuis J, Barbalic M, Bis JC, Eiriksdottir G, Lu C, Pellikka N, Wallaschofski H et al. ( 2011 ) . Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels . Circulation vol. 123 , ( 7 ) 731 - 738 .

( 2011 ) . Correction . Hypertension vol. 57 , ( 2 )

Li S, Zhao JH, Luan J, Langenberg C, Luben RN, Khaw KT, Wareham NJ, Loos RJF ( 2011 ) . Genetic predisposition to obesity leads to increased risk of type 2 diabetes . Diabetologia vol. 54 , ( 4 ) 776 - 782 .

Lanktree MB, Guo YR, Murtaza M, Glessner JT, Bailey SD, Onland-Moret NC, Lettre G, Ongen H et al. ( 2011 ) . Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height . AM J HUM GENET vol. 88 , ( 1 ) 6 - 18 .

Park JY, Mitrou PN, Keogh RH, Luben RN, Wareham NJ, Khaw K-T ( 2010 ) . Effects of body size and sociodemographic characteristics on differences between self-reported and measured anthropometric data in middle-aged men and women: the EPIC-Norfolk study . European Journal of Clinical Nutrition vol. 65 , ( 3 ) 357 - 367 .

Ducci F, Kaakinen M, Pouta A, Hartikainen A-L, Veijola J, Isohanni M, Charoen P, Coin L et al. ( 2010 ) . TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 Influence Different Pathways Leading to Smoking Behavior from Adolescence to Mid-Adulthood . Biological Psychiatry vol. 69 , ( 7 ) 650 - 660 .

Sotoodehnia N, Isaacs A, de Bakker PIW, Dorr M, Newton-Cheh C, Nolte IM, van der Harst P, Muller M et al. ( 2010 ) . Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction . NAT GENET vol. 42 , ( 12 ) 1068 - U62 .

Dominiczak AF, Munroe PB ( 2010 ) . Genome-Wide Association Studies Will Unlock the Genetic Basis of Hypertension . Hypertension vol. 56 , ( 6 ) 1017 - 1020 .

Loh YH, Mitrou PN, Wood A, Luben RN, McTaggart A, Khaw K-T, Rodwell SA ( 2010 ) . SMAD7 and MGMT genotype variants and cancer incidence in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk Study . Cancer Epidemiology vol. 35 , ( 4 ) 369 - 374 .

Kremeyer B, García J, Müller H, Burley MW, Herzberg I, Parra MV, Duque C, Vega J et al. ( 2010 ) . Genome-Wide Linkage Scan of Bipolar Disorder in a Colombian Population Isolate Replicates Loci on Chromosomes 7p21–22, 1p31, 16p12 and 21q21–22 and Identifies a Novel Locus on Chromosome 12q . Human Heredity vol. 70 , ( 4 ) 255 - 268 .

Crane J, Fagerness J, Osiecki L, Gunnell B, Stewart SE, Pauls DL, Scharf JM, Genetics TTSICF ( 2010 ) . Family‐based genetic association study of DLGAP3 in Tourette Syndrome . American Journal of Medical Genetics Part B Neuropsychiatric Genetics vol. 156 , ( 1 ) 108 - 114 .

Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Lango Allen H, Lindgren CM et al. ( 2010 ) . Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index . Nat Genet vol. 42 , ( 11 ) 937 - 948 .

Lovell MJ, Yasin M, Lee KL, Cheung KK, Shintani Y, Collino M, Sivarajah A, Leung K-Y et al. ( 2010 ) . Bone marrow mononuclear cells reduce myocardial reperfusion injury by activating the PI3K/Akt survival pathway . Atherosclerosis vol. 213 , ( 1 ) 67 - 76 .

Tabara Y, Kohara K, Kita Y, Hirawa N, Katsuya T, Ohkubo T, Hiura Y, Tajima A et al. ( 2010 ) . Common variants in the ATP2B1 gene are associated with susceptibility to hypertension: the Japanese Millennium Genome Project . Hypertension vol. 56 , ( 5 ) 973 - 980 .

Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, Thorleifsson G, Zillikens MC et al. ( 2010 ) . Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution . Nat Genet vol. 42 , ( 11 ) 949 - 960 .

Padmanabhan S, Melander O, Johnson T, Di Blasio AM, Lee WK, Gentilini D, Hastie CE, Menni C et al. ( 2010 ) . Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension . PLoS Genet vol. 6 , ( 10 )

Sivapalaratnam S, Boekholdt SM, Trip MD, Sandhu MS, Luben R, Kastelein JJP, Wareham NJ, Khaw K-T ( 2010 ) . Family history of premature coronary heart disease and risk prediction in the EPIC-Norfolk prospective population study . Heart vol. 96 , ( 24 )

Gkrania-Klotsas E, Ye Z, Cooper AJ, Sharp SJ, Luben R, Biggs ML, Chen L-K, Gokulakrishnan K et al. ( 2010 ) . Differential White Blood Cell Count and Type 2 Diabetes: Systematic Review and Meta-Analysis of Cross-Sectional and Prospective Studies . PLOS ONE vol. 5 , ( 10 )

Allen HL, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F, Willer CJ, Jackson AU et al. ( 2010 ) . Hundreds of variants clustered in genomic loci and biological pathways affect human height . NATURE vol. 467 , ( 7317 ) 832 - 838 .

Woods RP, Fears SC, Jorgensen MJ, Fairbanks LA, Toga AW, Freimer NB ( 2010 ) . A web-based brain atlas of the vervet monkey, Chlorocebus aethiops . NeuroImage vol. 54 , ( 3 ) 1872 - 1880 .

Johnson T, Shaw-Hawkins S, Howard P, Lathrop M, Stanton A, Shields D, Poulter N, Sever P et al. ( 2010 ) . A novel gene locus for blood pressure variability identified by genomewide association scanning in the Anglo-Scandinavian Cardiac Outcome Trial . J HUM HYPERTENS vol. 24 , ( 10 ) 694 - 694 .

Hastie CE, Padmanabhan S, Melander O, Johnson T, Di Blasio AM, Munroe PB, Caulfield M, Zanchetti A et al. ( 2010 ) . Genome wide association study of blood pressure extremes identifies variant in uromodulin gene associated with hypertension . J HUM HYPERTENS vol. 24 , ( 10 ) 687 - 687 .

Munroe PB, Human CVD55 Blood Pressure Consort ( 2010 ) . Meta-analyses of the HumanCVD55 beadchip discovers new blood pressure genes . J HUM HYPERTENS vol. 24 , ( 10 ) 696 - 696 .

Congdon E, Poldrack RA, Freimer NB ( 2010 ) . Neurocognitive Phenotypes and Genetic Dissection of Disorders of Brain and Behavior . Neuron vol. 68 , ( 2 ) 218 - 230 .

Waterworth DM, Ricketts SL, Song K, Chen L, Zhao JH, Ripatti S, Aulchenko YS, Zhang W et al. ( 2010 ) . Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease . Arteriosclerosis Thrombosis and Vascular Biology vol. 30 , ( 11 ) 2264 - 2276 .

Patel PS, Sharp SJ, Jansen E, Luben RN, Khaw K-T, Wareham NJ, Forouhi NG ( 2010 ) . Fatty acids measured in plasma and erythrocyte-membrane phospholipids and derived by food-frequency questionnaire and the risk of new-onset type 2 diabetes: a pilot study in the European Prospective Investigation into Cancer and Nutrition (EPIC)–Norfolk cohort . American Journal of Clinical Nutrition vol. 92 , ( 5 ) 1214 - 1222 .

Li S, Zhao JH, Luan J, Ekelund U, Luben RN, Khaw K-T, Wareham NJ, Loos RJF ( 2010 ) . Physical Activity Attenuates the Genetic Predisposition to Obesity in 20,000 Men and Women from EPIC-Norfolk Prospective Population Study . PLOS Medicine vol. 7 , ( 8 )

Desrivières S, Lourdusamy A, Müller C, Ducci F, Wong CP, Kaakinen M, Pouta A, Hartikainen A et al. ( 2010 ) . Glucocorticoid receptor (NR3C1) gene polymorphisms and onset of alcohol abuse in adolescents . Addiction Biology vol. 16 , ( 3 ) 510 - 513 .

Ward H, Luben RN, Wareham NJ, Khaw K-T ( 2010 ) . CHD risk in relation to alcohol intake from categorical and open-ended dietary instruments . Public Health Nutrition vol. 14 , ( 3 ) 402 - 409 .

Dahm CC, Keogh RH, Lentjes MAH, Spencer EA, Key TJ, Greenwood DC, Cade JE, Burley VJ et al. ( 2010 ) . Intake of dietary fats and colorectal cancer risk: Prospective findings from the UK Dietary Cohort Consortium . Cancer Epidemiology vol. 34 , ( 5 ) 562 - 567 .

Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP, Ripatti S et al. ( 2010 ) . Biological, clinical and population relevance of 95 loci for blood lipids . NATURE vol. 466 , ( 7307 ) 707 - 713 .

Banim PJR, Luben RN, Wareham NJ, Sharp SJ, Khaw K-T, Hart AR ( 2010 ) . Physical activity reduces the risk of symptomatic gallstones: a prospective cohort study . European Journal of Gastroenterology & Hepatology vol. 22 , ( 8 ) 983 - 988 .

Park JY, Dahm CC, Keogh RH, Mitrou PN, Cairns BJ, Greenwood DC, Spencer EA, Fentiman IS et al. ( 2010 ) . Alcohol intake and risk of colorectal cancer: Results from the UK Dietary Cohort Consortium . British Journal of Cancer vol. 103 , ( 5 ) 747 - 756 .

Surtees PG, Wainwright NWJ, Luben R, Wareham NJ, Bingham SA, Khaw K-T ( 2010 ) . Mastery Is Associated With Cardiovascular Disease Mortality in Men and Women at Apparently Low Risk . Health Psychology vol. 29 , ( 4 ) 412 - 420 .

Foster PJ, Broadway DC, Hayat S, Luben R, Dalzell N, Bingham S, Wareham NJ, Khaw K-T ( 2010 ) . Refractive error, axial length and anterior chamber depth of the eye in British adults: the EPIC-Norfolk Eye Study . British Journal of Ophthalmology vol. 94 , ( 7 )

Moayyeri A, Besson H, Luben RN, Wareham NJ, Khaw K-T ( 2010 ) . The association between physical activity in different domains of life and risk of osteoporotic fractures . Bone vol. 47 , ( 3 ) 693 - 700 .

Wijndaele K, Brage S, Besson H, Khaw K-T, Sharp SJ, Luben R, Wareham NJ, Ekelund U ( 2010 ) . Television viewing time independently predicts all-cause and cardiovascular mortality: the EPIC Norfolk Study . International Journal of Epidemiology vol. 40 , ( 1 ) 150 - 159 .

Freitas RN, Khaw K-T, Wu K, Bowman R, Jeffery H, Luben R, Wareham NJ, Bingham SA ( 2010 ) . A single nucleotide polymorphism in the 3-hydroxy-3-methylglutaryl-coenzyme A reductase gene (HMGCR) influences the serum triacylglycerol relationship with dietary fat and fibre in the European Prospective Investigation into Cancer and Nutrition in Norfolk (EPIC-Norfolk) study . British Journal Of Nutrition vol. 104 , ( 5 ) 765 - 772 .

Padmanabhan S, Melander O, Johnson T, Di Blasio AM, Lee WK, Navis G, Bochud M, Munroe PB et al. ( 2010 ) . GENOME WIDE ASSOCIATION STUDY OF BLOOD PRESSURE EXTREMES IDENTIFIES VARIANT IN UMOD ASSOCIATED WITH HYPERTENSION . JOURNAL OF HYPERTENSION . vol. 28 , E237 - E237 .

Alvarez-Madrazo S, Padmanabhan S, Friel E, MacKenzie SM, Brown MJ, Caulfield MJ, Munroe PB, Farrall M et al. ( 2010 ) . Validation of Association of Hypertension at the CYP11B1/B2 Locus in Caucasians . ENDOCRINE REVIEWS . vol. 31 ,

Miettunen J, Veijola J, Freimer N, Lichtermann D, Peltonen L, Paunio T, Isohanni M, Joukamaa M et al. ( 2010 ) . Data on schizotypy and affective scales are gender and education dependent — Study in the Northern Finland 1966 Birth Cohort . Psychiatry Research vol. 178 , ( 2 ) 408 - 413 .

Bilder RM, Poldrack RA, Parker DS, Reise SP, Jentsch JD, Cannon T, London E, Sabb FW et al. ( 2010 ) . Cognitive phenomics . The Neuropsychology of Mental Illness , Cambridge University Press (CUP)

John S, Luben R, Shrestha SS, Welch A, Khaw K-T, Hart AR ( 2010 ) . Dietary n-3 polyunsaturated fatty acids and the aetiology of ulcerative colitis: a UK prospective cohort study . European Journal of Gastroenterology & Hepatology vol. 22 , ( 5 ) 602 - 606 .

Chambers JC, Zhang WH, Lord GM, van der Harst P, Lawlor DA, Sehmi JS, Gale DP, Wass MN et al. ( 2010 ) . Genetic loci influencing kidney function and chronic kidney disease . NAT GENET vol. 42 , ( 5 ) 373 - 375 .

Spencer EA, Key TJ, Appleby PN, Dahm CC, Keogh RH, Fentiman IS, Akbaraly T, Brunner EJ et al. ( 2010 ) . Meat, poultry and fish and risk of colorectal cancer: pooled analysis of data from the UK dietary cohort consortium . Cancer Causes & Control vol. 21 , ( 9 ) 1417 - 1425 .

Liu JZ, Tozzi F, Waterworth DM, Pillai SG, Muglia P, Middleton L, Berrettini W, Knouff CW et al. ( 2010 ) . Meta-analysis and imputation refines the association of 15q25 with smoking quantity . NAT GENET vol. 42 , ( 5 ) 436 - U75 .

Myint PK, Luben RN, Surtees PG, Wainwright NW, Wareham NJ, Khaw K-T ( 2010 ) . Physical functional health predicts the incidence of coronary heart disease in the European Prospective Investigation into Cancer-Norfolk prospective population-based study . International Journal of Epidemiology vol. 39 , ( 4 ) 996 - 1003 .

Dahm CC, Keogh RH, Spencer EA, Greenwood DC, Key TJ, Fentiman IS, Shipley MJ, Brunner EJ et al. ( 2010 ) . Dietary Fiber and Colorectal Cancer Risk: A Nested Case–Control Study Using Food Diaries . Journal of the National Cancer Institute vol. 102 , ( 9 ) 614 - 626 .

Widén E, Ripatti S, Cousminer DL, Surakka I, Lappalainen T, Järvelin M-R, Eriksson JG, Raitakari O et al. ( 2010 ) . Distinct Variants at LIN28B Influence Growth in Height from Birth to Adulthood . American Journal of Human Genetics vol. 86 , ( 5 ) 773 - 782 .

Pooley KA, Sandhu MS, Tyrer J, Shah M, Driver KE, Luben RN, Bingham SA, Ponder BAJ et al. ( 2010 ) . Telomere Length in Prospective and Retrospective Cancer Case-Control Studies . Cancer Research vol. 70 , ( 8 ) 3170 - 3176 .

Pawlikowska L, Strautnieks S, Jankowska I, Czubkowski P, Emerick K, Antoniou A, Wanty C, Fischler B et al. ( 2010 ) . Differences in presentation and progression between severe FIC1 and BSEP deficiencies . Journal of Hepatology vol. 53 , ( 1 ) 170 - 178 .

Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, Qi L, Speliotes EK, Thorleifsson G et al. ( 2010 ) . Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution . PLOS GENET vol. 6 , ( 4 ) Article e1000508 ,

Craddock N, Hurles ME, Cardin N, Pearson RD, Plagnol V, Robson S, Vukcevic D, Barnes C et al. ( 2010 ) . Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls . NATURE vol. 464 , ( 7289 ) 713 - U86 .

Udler MS, Ahmed S, Healey CS, Meyer K, Struewing J, Maranian M, Kwon EM, Zhang J et al. ( 2010 ) . Fine scale mapping of the breast cancer 16q12 locus . Human Molecular Genetics vol. 19 , ( 12 ) 2507 - 2515 .

Naguib A, Mitrou PN, Gay LJ, Cooke JC, Luben RN, Ball RY, McTaggart A, Arends MJ et al. ( 2010 ) . Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study . BMC Cancer vol. 10 , ( 1 )

Park JY, Mitrou PN, Keen J, Dahm CC, Gay LJ, Luben RN, McTaggart A, Khaw K-T et al. ( 2010 ) . Lifestyle factors and p53 mutation patterns in colorectal cancer patients in the EPIC-Norfolk study . Mutagenesis vol. 25 , ( 4 ) 351 - 358 .

Kang HM, Sul JH, Service SK, Zaitlen NA, Kong S-Y, Freimer NB, Sabatti C, Eskin E ( 2010 ) . Variance component model to account for sample structure in genome-wide association studies . Nature Genetics vol. 42 , ( 4 ) 348 - 354 .

Pillas D, Hoggart CJ, Evans DM, O'Reilly PF, Sipilä K, Lähdesmäki R, Millwood IY, Kaakinen M et al. ( 2010 ) . Genome-Wide Association Study Reveals Multiple Loci Associated with Primary Tooth Development during Infancy . PLOS Genetics vol. 6 , ( 2 )

Knight S, Coon H, Johnson M, Leppert MF, Camp NJ, McMahon WM, Genetics TSAICF ( 2010 ) . Linkage analysis of Tourette syndrome in a large utah pedigree . American Journal of Medical Genetics Part B Neuropsychiatric Genetics vol. 153B , ( 2 ) 656 - 662 .

Boekholdt SM, Titan SM, Wiersinga WM, Chatterjee K, Basart DCG, Luben R, Wareham NJ, Khaw K ( 2010 ) . Initial thyroid status and cardiovascular risk factors: The EPIC‐Norfolk prospective population study . Clinical Endocrinology vol. 72 , ( 3 ) 404 - 410 .

Freitas RN, Khaw K-T, Wu K, Bowman R, Jeffery H, Luben R, Wareham NJ, Rodwell S ( 2010 ) . HMGCR gene polymorphism is associated with stroke risk in the EPIC-Norfolk study . European Journal of Preventive Cardiology vol. 17 , ( 1 ) 89 - 93 .

Loh YH, Mitrou PN, Bowman R, Wood A, Jeffery H, Luben RN, Lentjes MAH, Khaw K-T et al. ( 2010 ) . MGMT Ile143Val polymorphism, dietary factors and the risk of breast, colorectal and prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk study . DNA Repair vol. 9 , ( 4 ) 421 - 428 .

Steinberg S, Mors O, Børglum AD, Gustafsson O, Werge T, Mortensen PB, Andreassen OA, Sigurdsson E et al. ( 2010 ) . Expanding the range of ZNF804A variants conferring risk of psychosis . Molecular Psychiatry vol. 16 , ( 1 ) 59 - 66 .

Ward HA, Kuhnle GGC, Mulligan AA, Lentjes MAH, Luben RN, Khaw K-T ( 2009 ) . Breast, colorectal, and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition–Norfolk in relation to phytoestrogen intake derived from an improved database . American Journal of Clinical Nutrition vol. 91 , ( 2 ) 440 - 448 .

Moayyeri A, Kaptoge S, Dalzell N, Bingham S, Luben RN, Wareham NJ, Reeve J, Khaw KT ( 2009 ) . Is QUS or DXA Better for Predicting the 10‐Year Absolute Risk of Fracture?1* . Journal of Bone and Mineral Research vol. 24 , ( 7 ) 1319 - 1325 .

Moayyeri A, Luben RN, Bingham SA, Welch AA, Wareham NJ, Khaw K ( 2009 ) . Measured Height Loss Predicts Fractures in Middle‐Aged and Older Men and Women: The EPIC‐Norfolk Prospective Population Study* . Journal of Bone and Mineral Research vol. 23 , ( 3 ) 425 - 432 .

Moayyeri A, Bingham SA, Luben RN, Wareham NJ, Khaw K ( 2009 ) . Respiratory Function as a Marker of Bone Health and Fracture Risk in an Older Population* . Journal of Bone and Mineral Research vol. 24 , ( 5 ) 956 - 963 .

Park JY, Mitrou PN, Dahm CC, Luben RN, Wareham NJ, Khaw K-T, Rodwell SA ( 2009 ) . Baseline alcohol consumption, type of alcoholic beverage and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition-Norfolk study . Cancer Epidemiology vol. 33 , ( 5 ) 347 - 354 .

Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J et al. ( 2009 ) . Gene-centric Association Signals for Lipids and Apolipoproteins Identified via the HumanCVD BeadChip . AM J HUM GENET vol. 85 , ( 5 ) 628 - 642 .

Munroe PB, Johnson T, Caulfield MJ ( 2009 ) . The genetic architecture of blood pressure variation . Current Cardiovascular Risk Reports vol. 3 , ( 6 )

Lakshman R, Forouhi NG, Sharp SJ, Luben R, Bingham SA, Khaw K-T, Wareham NJ, Ong KK ( 2009 ) . Early Age at Menarche Associated with Cardiovascular Disease and Mortality . The Journal of Clinical Endocrinology & Metabolism vol. 94 , ( 12 ) 4953 - 4960 .

Chambers JC, Zhang W, Li Y, Sehmi J, Wass MN, Zabaneh D, Hoggart C, Bayele H et al. ( 2009 ) . Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels . Nature Genetics vol. 41 , ( 11 ) 1170 - 1172 .

Li S, Zhao JH, Luan J, Luben RN, Rodwell SA, Khaw K-T, Ong KK, Wareham NJ et al. ( 2009 ) . Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies . American Journal of Clinical Nutrition vol. 91 , ( 1 ) 184 - 190 .

Jasinska AJ, Freimer NB ( 2009 ) . The complex genetic basis of simple behavior . BMC Biology vol. 8 , ( 8 )

Dobson RJB, Munroe PB, Caulfield MJ, Saqi MAS ( 2009 ) . Global sequence properties for superfamily prediction: a machine learning approach . J Integr Bioinform vol. 6 , ( 1 )

Nyman ES, Loukola A, Varilo T, Ekelund J, Veijola J, Joukamaa M, Taanila A, Pouta A et al. ( 2009 ) . Impact of the dopamine receptor gene family on temperament traits in a population‐based birth cohort . American Journal of Medical Genetics Part B Neuropsychiatric Genetics vol. 150B , ( 6 ) 854 - 865 .

Jasinska AJ, Service S, Choi O-W, DeYoung J, Grujic O, Kong S-Y, Jorgensen MJ, Bailey J et al. ( 2009 ) . Identification of brain transcriptional variation reproduced in peripheral blood: an approach for mapping brain expression traits . Human Molecular Genetics vol. 18 , ( 22 ) 4415 - 4427 .

Myint PK, Smith RD, Luben RN, Surtees PG, Wainwright NWJ, Wareham NJ, Bingham SA, Khaw K-T ( 2009 ) . The Short-Form Six-Dimension utility index predicted mortality in the European Prospective Investigation into Cancer-Norfolk prospective population-based study . Journal of Clinical Epidemiology vol. 63 , ( 2 ) 192 - 198 .

Ward H, Mitrou PN, Bowman R, Luben R, Wareham NJ, Khaw K-T, Bingham S ( 2009 ) . APOE Genotype, Lipids, and Coronary Heart Disease Risk: A Prospective Population Study . JAMA Internal Medicine vol. 169 , ( 15 ) 1424 - 1429 .

Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, Qi L, Speliotes EK, Thorleifsson G et al. ( 2009 ) . Correction: Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution . PLOS Genetics vol. 5 , ( 7 )

Tjonneland A, Overvad K, Bergmann MM, Nagel G, Linseisen J, Hallmans G, Palmqvist R, Sjodin H et al. ( 2009 ) . Linoleic acid, a dietary n-6 polyunsaturated fatty acid, and the aetiology of ulcerative colitis: a nested case–control study within a European prospective cohort study . Gut vol. 58 , ( 12 )

Patel PS, Sharp SJ, Luben RN, Khaw K-T, Bingham SA, Wareham NJ, Forouhi NG ( 2009 ) . Association Between Type of Dietary Fish and Seafood Intake and the Risk of Incident Type 2 Diabetes The European Prospective Investigation of Cancer (EPIC)-Norfolk cohort study . Diabetes Care vol. 32 , ( 10 ) 1857 - 1863 .

Nolte IM, Wallace C, Newhouse SJ, Waggott D, Fu J, Soranzo N, Gwilliam R, Deloukas P et al. ( 2009 ) . Common Genetic Variation Near the Phospholamban Gene Is Associated with Cardiac Repolarisation: Meta-Analysis of Three Genome-Wide Association Studies . PLOS ONE vol. 4 , ( 7 )

Eksandh L, Ponjavic V, Munroe PB, Eiberg H, Uvebrant P, Ehinger B, Mole SE, Andréasson S ( 2009 ) . Full-field ERG in patients with Batten/Spielmeyer-Vogt disease caused by mutations in the CLN3 gene . Ophthalmic Genetics vol. 21 , ( 2 ) 69 - 77 .

Surtees PG, Wainwright NWJ, Luben RN, Khaw K-T, Bingham SA ( 2009 ) . No evidence that social stress is associated with breast cancer incidence . Breast Cancer Research and Treatment vol. 120 , ( 1 ) 169 - 174 .

Freitas RN, Khaw K-T, Wu K, Bowman R, Jeffery H, Luben R, Wareham NJ, Bingham SA ( 2009 ) . A HMGCR polymorphism is associated with relations between blood pressure and urinary sodium and potassium ratio in the Epic-Norfolk Study . International Journal of Cardiology Cardiovascular Risk and Prevention vol. 3 , ( 4 ) 238 - 244 .

Bilder RM, Sabb FW, Parker DS, Kalar D, Chu WW, Fox J, Freimer NB, Poldrack RA ( 2009 ) . Cognitive ontologies for neuropsychiatric phenomics research . Cognitive Neuropsychiatry vol. 14 , ( 4-5 ) 419 - 450 .

Stefansson H, Ophoff RA, Steinberg S, Andreassen OA, Cichon S, Rujescu D, Werge T, Pietiläinen OPH et al. ( 2009 ) . Common variants conferring risk of schizophrenia . Nature vol. 460 , ( 7256 ) 744 - 747 .

Elliott P, Chambers JC, Zhang W, Clarke R, Hopewell JC, Peden JF, Erdmann J, Braund P et al. ( 2009 ) . Genetic Loci Associated With C-Reactive Protein Levels and Risk of Coronary Heart Disease . JAMA vol. 302 , ( 1 ) 37 - 48 .

Sõber S, Org E, Kepp K, Juhanson P, Eyheramendy S, Gieger C, Lichtner P, Klopp N et al. ( 2009 ) . Targeting 160 Candidate Genes for Blood Pressure Regulation with a Genome-Wide Genotyping Array . PLOS ONE vol. 4 , ( 6 )

Org E, Eyheramendy S, Juhanson P, Gieger C, Lichtner P, Klopp N, Veldre G, Doring A et al. ( 2009 ) . Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations . HUM MOL GENET vol. 18 , ( 12 ) 2288 - 2296 .

Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, Qi L, Speliotes EK, Thorleifsson G et al. ( 2009 ) . Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution . PLOS GENET vol. 5 , ( 6 ) Article e1000508 ,

Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L, Najjar SS, Zhao JH et al. ( 2009 ) . Genome-wide association study identifies eight loci associated with blood pressure . NAT GENET vol. 41 , ( 6 ) 666 - 676 .

Kolz M, Johnson T, Sanna S, Teumer A, Vitart V, Perola M, Mangino M, Albrecht E et al. ( 2009 ) . Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations . PLOS GENET vol. 5 , ( 6 ) Article e1000504 ,

Sabb FW, Burggren AC, Higier RG, Fox J, He J, Parker DS, Poldrack RA, Chu W et al. ( 2009 ) . Challenges in phenotype definition in the whole-genome era: multivariate models of memory and intelligence . Neuroscience vol. 164 , ( 1 ) 88 - 107 .

Ong KK, Elks CE, Li S, Zhao JH, Luan J, Andersen LB, Bingham SA, Brage S et al. ( 2009 ) . Genetic variation in LIN28B is associated with the timing of puberty . Nature Genetics vol. 41 , ( 6 ) 729 - 733 .

Moayyeri A, Kaptoge S, Dalzell N, Luben RN, Wareham NJ, Bingham S, Reeve J, Khaw KT ( 2009 ) . The effect of including quantitative heel ultrasound in models for estimation of 10-year absolute risk of fracture . Bone vol. 45 , ( 2 ) 180 - 184 .

Myint PK, Luben RN, Surtees PG, Wainwright NWJ, Bingham SA, Wareham NJ, Khaw K-T ( 2009 ) . Effect of Age and Sex on the Relationship Between Different Socioeconomic Indices and Self-Reported Functional Health in the EPIC-Norfolk Population-Based Study . Annals of Epidemiology vol. 19 , ( 5 ) 289 - 297 .

Moayyeri A, Kaptoge S, Luben RN, Wareham NJ, Bingham S, Reeve J, Khaw KT ( 2009 ) . Estimation of absolute fracture risk among middle-aged and older men and women: the EPIC-Norfolk population cohort study . European Journal of Epidemiology vol. 24 , ( 5 )

Bearden CE, Jasinska AJ, Freimer NB ( 2009 ) . Methodological Issues in Molecular Genetic Studies of Mental Disorders . Annual Reviews

Ahmed S, Thomas G, Ghoussaini M, Healey CS, Humphreys MK, Platte R, Morrison J, Maranian M et al. ( 2009 ) . Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2 . Nature Genetics vol. 41 , ( 5 ) 585 - 590 .

Lee CC, Adler AI, Sandhu MS, Sharp SJ, Forouhi NG, Erqou S, Luben R, Bingham S et al. ( 2009 ) . Association of C-reactive protein with type 2 diabetes: prospective analysis and meta-analysis . Diabetologia vol. 52 , ( 6 ) 1040 - 1047 .

McFadden E, Luben R, Khaw K-T ( 2009 ) . Different measures of social class in women and mortality . European Journal of Epidemiology vol. 24 , ( 5 ) 231 - 236 .

Semb AG, Ueland T, Aukrust P, Wareham NJ, Luben R, Gullestad L, Kastelein JJP, Khaw K-T et al. ( 2009 ) . Osteoprotegerin and Soluble Receptor Activator of Nuclear Factor-&kgr;B Ligand and Risk for Coronary Events . Arteriosclerosis Thrombosis and Vascular Biology vol. 29 , ( 6 ) 975 - 980 .

Jasinska AJ, Service S, Jawaheer D, DeYoung J, Levinson M, Zhang Z, Kremeyer B, Muller H et al. ( 2009 ) . A narrow and highly significant linkage signal for severe bipolar disorder in the chromosome 5q33 region in Latin American pedigrees . American Journal of Medical Genetics Part B Neuropsychiatric Genetics vol. 150B , ( 7 ) 998 - 1006 .

McFadden E, Luben R, Wareham N, Bingham S, Khaw K-T ( 2009 ) . How far can we explain the social class differential in respiratory function? A cross-sectional population study of 21,991 men and women from EPIC-Norfolk . European Journal of Epidemiology vol. 24 , ( 4 ) 193 - 201 .

Sovio U, Bennett AJ, Millwood IY, Molitor J, O'Reilly PF, Timpson NJ, Kaakinen M, Laitinen J et al. ( 2009 ) . Genetic Determinants of Height Growth Assessed Longitudinally from Infancy to Adulthood in the Northern Finland Birth Cohort 1966 . PLOS Genetics vol. 5 , ( 3 )

Fears SC, Melega WP, Service SK, Lee C, Chen K, Tu Z, Jorgensen MJ, Fairbanks LA et al. ( 2009 ) . Identifying Heritable Brain Phenotypes in an Extended Pedigree of Vervet Monkeys . Journal of Neuroscience vol. 29 , ( 9 ) 2867 - 2875 .

Myint PK, Luben RN, Wareham NJ, Bingham SA, Khaw K-T ( 2009 ) . Combined effect of health behaviours and risk of first ever stroke in 20 040 men and women over 11 years’ follow-up in Norfolk cohort of European Prospective Investigation of Cancer (EPIC Norfolk): prospective population study . The BMJ vol. 338 , ( feb19 2 )

McFadden E, Luben R, Wareham N, Bingham S, Khaw K-T ( 2009 ) . Social Class, Risk Factors, and Stroke Incidence in Men and Women . Stroke vol. 40 , ( 4 ) 1070 - 1077 .

Udler MS, Meyer KB, Pooley KA, Karlins E, Struewing JP, Zhang J, Doody DR, MacArthur S et al. ( 2009 ) . FGFR2 variants and breast cancer risk: fine-scale mapping using African American studies and analysis of chromatin conformation . Human Molecular Genetics vol. 18 , ( 9 ) 1692 - 1703 .

Bilder RM, Sabb FW, Cannon TD, London ED, Jentsch JD, Parker DS, Poldrack RA, Evans C et al. ( 2009 ) . Phenomics: the systematic study of phenotypes on a genome-wide scale . Neuroscience vol. 164 , ( 1 ) 30 - 42 .

McFadden E, Luben R, Bingham S, Wareham N, Kinmonth A-L, Khaw K-T ( 2009 ) . Self-rated health does not explain the socioeconomic differential in mortality: a prospective study in the EPIC-Norfolk cohort . Journal of Epidemiology & Community Health vol. 63 , ( 4 )

Surtees PG, Wainwright NWJ, Bowman R, Luben RN, Wareham NJ, Khaw K-T, Bingham SA ( 2009 ) . No association between APOE and major depressive disorder in a community sample of 17,507 adults . Journal of Psychiatric Research vol. 43 , ( 9 ) 843 - 847 .

Newhouse S, Farrall M, Wallace C, Hoti M, Burke B, Howard P, Onipinla A, Lee K et al. ( 2009 ) . Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion . PLoS One vol. 4 , ( 4 )

Willer CJ, Speliotes EK, Loos RJF, Li SX, Lindgren CM, Heid IM, Berndt SI, Elliott AL et al. ( 2009 ) . Six new loci associated with body mass index highlight a neuronal influence on body weight regulation . NAT GENET vol. 41 , ( 1 ) 25 - 34 .

Thompson DJ, Healey CS, Baynes C, Kalmyrzaev B, Ahmed S, Dowsett M, Folkerd E, Luben RN et al. ( 2008 ) . Identification of Common Variants in the SHBG Gene Affecting Sex Hormone-Binding Globulin Levels and Breast Cancer Risk in Postmenopausal Women . Cancer Epidemiology Biomarkers & Prevention vol. 17 , ( 12 ) 3490 - 3498 .

Sabatti C, Service SK, Hartikainen A-L, Pouta A, Ripatti S, Brodsky J, Jones CG, Zaitlen NA et al. ( 2008 ) . Genome-wide association analysis of metabolic traits in a birth cohort from a founder population . Nature Genetics vol. 41 , ( 1 ) 35 - 46 .

( 2008 ) . Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts . Nature Genetics vol. 41 , ( 1 ) 47 - 55 .

Prokopenko I, Langenberg C, Florez JC, Saxena R, Soranzo N, Thorleifsson G, Loos RJF, Manning AK et al. ( 2008 ) . Variants in MTNR1B influence fasting glucose levels . Nature Genetics vol. 41 , ( 1 ) 77 - 81 .

Bingham S, Luben R, Welch A, Low YL, Khaw KT, Wareham N, Day N ( 2008 ) . Author's Response . International Journal of Epidemiology vol. 38 , ( 3 ) 885 - 885 .

Myint PK, Sinha S, Luben RN, Bingham SA, Wareham NJ, Khaw K-T ( 2008 ) . Risk factors for first-ever stroke in the EPIC-Norfolk prospective population-based study . European Journal of Preventive Cardiology vol. 15 , ( 6 ) 663 - 669 .

Jakkula E, Rehnström K, Varilo T, Pietiläinen OPH, Paunio T, Pedersen NL, deFaire U, Järvelin M-R et al. ( 2008 ) . The Genome-wide Patterns of Variation Expose Significant Substructure in a Founder Population . American Journal of Human Genetics vol. 83 , ( 6 ) 787 - 794 .

McFadden E, Luben R, Bingham S, Wareham N, Kinmonth A-L, Khaw K-T ( 2008 ) . Does the association between self-rated health and mortality vary by social class? . Social Science & Medicine vol. 68 , ( 2 ) 275 - 280 .

Park JY, Mitrou PN, Luben R, Khaw K-T, Bingham SA ( 2008 ) . Is bowel habit linked to colorectal cancer? – Results from the EPIC-Norfolk study . European Journal of Cancer vol. 45 , ( 1 ) 139 - 145 .

Sinha S, Myint PK, Luben RN, Khaw K-T ( 2008 ) . Accuracy of death certification and hospital record linkage for identification of incident stroke . BMC Medical Research Methodology vol. 8 , ( 1 )

Cotton RGH, Auerbach AD, Axton M, Barash CI, Berkovic SF, Brookes AJ, Burn J, Cutting G et al. ( 2008 ) . The Human Variome Project . Science vol. 322 , ( 5903 ) 861 - 862 .

BESSON H, EKELUND U, BRAGE S, LUBEN R, BINGHAM S, KHAW K-T, WAREHAM NJ ( 2008 ) . Relationship between Subdomains of Total Physical Activity and Mortality . Medicine & Science in Sports & Exercise vol. 40 , ( 11 ) 1909 - 1915 .

Keating BJ, Tischfield S, Murray SS, Bhangale T, Price TS, Glessner JT, Galver L, Barrett JC et al. ( 2008 ) . Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies . PLOS ONE vol. 3 , ( 10 ) Article e3583 ,

Mallat Z, Simon T, Benessiano J, Clément K, Taleb S, Wareham NJ, Luben R, Khaw K-T et al. ( 2008 ) . Retinol-Binding Protein 4 and Prediction of Incident Coronary Events in Healthy Men and Women . The Journal of Clinical Endocrinology & Metabolism vol. 94 , ( 1 ) 255 - 260 .

Ward H, Chapelais G, Kuhnle GGC, Luben R, Khaw K-T, Bingham S ( 2008 ) . Lack of Prospective Associations between Plasma and Urinary Phytoestrogens and Risk of Prostate or Colorectal Cancer in the European Prospective into Cancer-Norfolk Study . Cancer Epidemiology Biomarkers & Prevention vol. 17 , ( 10 ) 2891 - 2894 .

Caulfield MJ, Munroe PB, O'Neill D, Witkowska K, Charchar FJ, Doblado M, Evans S, Eyheramendy S et al. ( 2008 ) . SLC2A9 is a high-capacity urate transporter in humans . PLoS Med vol. 5 , ( 10 )

Ishihara‐Paul L, Wainwright NWJ, Khaw K, Luben RN, Welch AA, Day NE, Brayne C, Surtees PG ( 2008 ) . Prospective association between emotional health and clinical evidence of Parkinson’s disease . European Journal of Neurology vol. 15 , ( 11 ) 1148 - 1154 .

Huq SM, Oldapo MNJ, Wang Y, Li J, Loo RL, Braund P, Tobin M, Barton P et al. ( 2008 ) . High glucose and low lactate: a metabolic signature of hypertension in human serum? . HYPERTENSION . vol. 52 , 758 - 759 .

Hoti M, Newhouse S, Clayton D, Samani NJ, Dominiczak AF, Brown MJ, Webster J, Lathrop M et al. ( 2008 ) . WNK1 - functional analyses of variants associated with blood pressure and essential hypertension . J HUM HYPERTENS . vol. 22 , 722 - 722 .

Hoti M, Newhouse S, Clayton D, Samani NJ, Dominiczak AF, Brown MJ, Webster J, Lathrop M et al. ( 2008 ) . WNK1-functional analyses of variants associated with blood pressure and essential hypertension . HYPERTENSION . vol. 52 , 764 - 764 .

Stefansson H, Rujescu D, Cichon S, Pietiläinen OPH, Ingason A, Steinberg S, Fossdal R, Sigurdsson E et al. ( 2008 ) . Large recurrent microdeletions associated with schizophrenia . Nature vol. 455 , ( 7210 ) 232 - 236 .

Surtees PG, Wainwright NWJ, Boekholdt SM, Luben RN, Wareham NJ, Khaw K-T ( 2008 ) . Major Depression, C-Reactive Protein, and Incident Ischemic Heart Disease in Healthy Men and Women . Psychosomatic Medicine vol. 70 , ( 8 ) 850 - 855 .

Wainwright NWJ, Surtees PG, Welch AA, Luben RN, Khaw K-T, Bingham SA ( 2008 ) . Sense of coherence, lifestyle choices and mortality . Journal of Epidemiology & Community Health vol. 62 , ( 9 )

Wang J, Luben R, Khaw K-T, Bingham S, Wareham NJ, Forouhi NG ( 2008 ) . Dietary Energy Density Predicts the Risk of Incident Type 2 Diabetes The European Prospective Investigation of Cancer (EPIC)-Norfolk Study . Diabetes Care vol. 31 , ( 11 ) 2120 - 2125 .

Norat T, Bowman R, Luben R, Welch A, Khaw KT, Wareham N, Bingham S ( 2008 ) . Blood pressure and interactions between the angiotensin polymorphism AGT M235T and sodium intake: a cross-sectional population study . American Journal of Clinical Nutrition vol. 88 , ( 2 ) 392 - 397 .

Harding A-H, Wareham NJ, Bingham SA, Khaw K, Luben R, Welch A, Forouhi NG ( 2008 ) . Plasma Vitamin C Level, Fruit and Vegetable Consumption, and the Risk of New-Onset Type 2 Diabetes Mellitus: The European Prospective Investigation of Cancer–Norfolk Prospective Study . JAMA Internal Medicine vol. 168 , ( 14 ) 1493 - 1499 .

McFadden E, Luben R, Bingham S, Wareham N, Kinmonth A-L, Khaw K-T ( 2008 ) . Social inequalities in self-rated health by age: Cross-sectional study of 22 457 middle-aged men and women . BMC Public Health vol. 8 , ( 1 )

Delles C, Padmanabhan S, Lee WK, Miller WH, McBride MW, McClure JD, Brain NJ, Wallace C et al. ( 2008 ) . Glutathione S-transferase variants and hypertension . J HYPERTENS vol. 26 , ( 7 ) 1343 - 1352 .

Bingham S, Luben R, Welch A, Low YL, Khaw KT, Wareham N, Day N ( 2008 ) . Associations between dietary methods and biomarkers, and between fruits and vegetables and risk of ischaemic heart disease, in the EPIC Norfolk Cohort Study . International Journal of Epidemiology vol. 37 , ( 5 ) 978 - 987 .

McFadden E, Luben R, Wareham N, Bingham S, Khaw K-T ( 2008 ) . Occupational social class, educational level, smoking and body mass index, and cause-specific mortality in men and women: a prospective study in the European Prospective Investigation of Cancer and Nutrition in Norfolk (EPIC-Norfolk) cohort . European Journal of Epidemiology vol. 23 , ( 8 )

Munafò MR, Freimer NB, Ng W, Ophoff R, Veijola J, Miettunen J, Järvelin M, Taanila A et al. ( 2008 ) . 5‐HTTLPR genotype and anxiety‐related personality traits: A meta‐analysis and new data . American Journal of Medical Genetics Part B Neuropsychiatric Genetics vol. 150B , ( 2 ) 271 - 281 .

Lee C-TC, Adler AI, Forouhi NG, Luben R, Welch A, Khaw K-T, Bingham S, Wareham NJ ( 2008 ) . Cross-sectional Association Between Fish Consumption and Albuminuria: The European Prospective Investigation of Cancer–Norfolk Study . American Journal of Kidney Diseases vol. 52 , ( 5 ) 876 - 886 .

Khaw K-T, Wareham N, Bingham S, Welch A, Luben R, Day N ( 2008 ) . Combined Impact of Health Behaviours and Mortality in Men and Women: The EPIC-Norfolk Prospective Population Study . Obstetrical & Gynecological Survey vol. 63 , ( 6 ) 376 - 377 .

Loos RJF, Lindgren CM, Li SX, Wheeler E, Zhao JH, Prokopenko I, Inouye M, Freathy RM et al. ( 2008 ) . Common variants near MC4R are associated with fat mass, weight and risk of obesity . NAT GENET vol. 40 , ( 6 ) 768 - 775 .

McFadden E, Luben R, Wareham N, Bingham S, Khaw K-T ( 2008 ) . Occupational social class, risk factors and cardiovascular disease incidence in men and women: a prospective study in the European Prospective Investigation of Cancer and Nutrition in Norfolk (EPIC-Norfolk) cohort . European Journal of Epidemiology vol. 23 , ( 7 )

Service S, Molina J, DeYoung J, Jawaheer D, Aldana I, Vu T, Araya C, Araya X et al. ( 2008 ) . Results of a SNP genome screen in a large Costa Rican Pedigree segregating for severe bipolar disorder . American Journal of Medical Genetics Part B Neuropsychiatric Genetics vol. 147B , ( 4 ) 540 - 540 .

Kerner B, Jasinska AJ, DeYoung J, Almonte M, Choi O, Freimer NB ( 2008 ) . Polymorphisms in the GRIA1 gene region in psychotic bipolar disorder . American Journal of Medical Genetics Part B Neuropsychiatric Genetics vol. 150B , ( 1 ) 24 - 32 .

Weedon MN, Lango H, Lindgren CM, Wallace C, Evans DM, Mangino M, Freathy RM, Perry JRB et al. ( 2008 ) . Genome-wide association analysis identifies 20 loci that influence adult height . NAT GENET vol. 40 , ( 5 ) 575 - 583 .

Ward H, Chapelais G, Kuhnle GG, Luben R, Khaw K-T, Bingham S ( 2008 ) . Breast cancer risk in relation to urinary and serum biomarkers of phytoestrogen exposure in the European Prospective into Cancer-Norfolk cohort study . Breast Cancer Research vol. 10 , ( 2 )

Scharf JM, Moorjani P, Fagerness J, Platko JV, Illmann C, Galloway B, Jenike E, Stewart SE et al. ( 2008 ) . Lack of association between SLITRK1var321 and tourette syndrome in a large family-based sample . Neurology vol. 70 , ( 16, Part 2 of 2 ) 1495 - 1496 .

Bowman R, Joosen AMCP, Welch AA, Luben RN, Khaw K-T, Wareham NJ, Bingham SA ( 2008 ) . Factor VII, blood lipids and fat intake: gene–nutrient interaction and risk of coronary heart disease with the factor VII R353Q polymorphism . European Journal of Clinical Nutrition vol. 63 , ( 6 ) 771 - 777 .

Purslow LR, Young EH, Wareham NJ, Forouhi N, Brunner EJ, Luben RN, Welch AA, Khaw K-T et al. ( 2008 ) . Socioeconomic position and risk of short-term weight gain: Prospective study of 14,619 middle-aged men and women . BMC Public Health vol. 8 , ( 1 )

Khaw K-T, Wareham N, Bingham S, Welch A, Luben R, Day N ( 2008 ) . Correction: Combined Impact of Health Behaviours and Mortality in Men and Women: The EPIC-Norfolk Prospective Population Study . PLOS Medicine vol. 5 , ( 3 )

Wang S, Ray N, Rojas W, Parra MV, Bedoya G, Gallo C, Poletti G, Mazzotti G et al. ( 2008 ) . Geographic Patterns of Genome Admixture in Latin American Mestizos . PLOS Genetics vol. 4 , ( 3 )

Hart AR, Luben R, Olsen A, Tjonneland A, Linseisen J, Nagel G, Berglund G, Lindgren S et al. ( 2008 ) . Diet in the Aetiology of Ulcerative Colitis: A European Prospective Cohort Study . Digestion vol. 77 , ( 1 ) 57 - 64 .

Lakshman R, Forouhi N, Luben R, Bingham S, Khaw K, Wareham N, Ong KK ( 2008 ) . Association between age at menarche and risk of diabetes in adults: results from the EPIC-Norfolk cohort study . Diabetologia vol. 51 , ( 5 ) 781 - 786 .

Surtees PG, Wainwright NWJ, Luben RN, Wareham NJ, Bingham SA, Khaw K-T ( 2008 ) . Psychological distress, major depressive disorder, and risk of strokeSYMBOL . Neurology vol. 70 , ( 10 ) 788 - 794 .

Surtees PG, Wainwright NWJ, Luben RN, Wareham NJ, Bingham SA, Khaw K-T ( 2008 ) . Depression and Ischemic Heart Disease Mortality: Evidence From the EPIC-Norfolk United Kingdom Prospective Cohort Study . American Journal of Psychiatry vol. 165 , ( 4 ) 515 - 523 .

Sandhu MS, Waterworth DM, Debenham SL, Wheeler E, Papadakis K, Zhao JH, Song K, Yuan X et al. ( 2008 ) . LDL-cholesterol concentrations: a genome-wide association study . The Lancet vol. 371 , ( 9611 ) 483 - 491 .

Hunninghake GM, Lasky-Su J, Soto-Quirós ME, Avila L, Liang C, Lake SL, Hudson TJ, Spesny M et al. ( 2008 ) . Sex-stratified Linkage Analysis Identifies a Female-specific Locus for IgE to Cockroach in Costa Ricans . American Journal of Respiratory and Critical Care Medicine vol. 177 , ( 8 ) 830 - 836 .

Hart AR, Luben R, Welch A, Bingham S, Khaw K-T ( 2008 ) . Hormone Replacement Therapy and Symptomatic Gallstones – A Prospective Population Study in the EPIC-Norfolk Cohort . Digestion vol. 77 , ( 1 ) 4 - 9 .

Sabb FW, Bearden CE, Glahn DC, Parker DS, Freimer N, Bilder RM ( 2008 ) . A collaborative knowledge base for cognitive phenomics . Molecular Psychiatry vol. 13 , ( 4 ) 350 - 360 .

Khaw K-T, Wareham N, Bingham S, Welch A, Luben R, Day N ( 2008 ) . Combined Impact of Health Behaviours and Mortality in Men and Women: The EPIC-Norfolk Prospective Population Study . PLOS Medicine vol. 5 , ( 1 )

Jarvik L, LaRue A, Blacker D, Gatz M, Kawas C, McArdle JJ, Morris JC, Mortimer JA et al. ( 2008 ) . Children of Persons With Alzheimer Disease . Alzheimer Disease & Associated Disorders vol. 22 , ( 1 ) 6 - 20 .

Dobson RJB, Munroe PB, Mein CA, Caulfield MJ, Saqi MAS ( 2008 ) . Combining protein-protein interaction (PPI) network and sequence attributes for predicting hypertension related proteins . BIOINFORMATICS RESEARCH AND DEVELOPMENT, PROCEEDINGS . Editors: Elloumi, M, Kung, J, Linial, M, Murphy, RF et al. , vol. 13 , 377 - 391 .

Doblado M, Munroe PB, O'Neill D, Witkowska K, Charchar F, Evans S, Caulfield MJ, Cheeseman CI et al. ( 2008 ) . Functional studies identify a glucose transporter SLC2A9 as a novel urate transporter . DIABETES . vol. 57 , A356 - A356 .

Wallace C, Newhouse SJ, Braund P, Zhang F, Tobin M, Falchi M, Ahmadi K, Dobson RJ et al. ( 2008 ) . Genome-wide association study identifies genes for biomarkers of cardiovascular disease: Serum urate and dyslipiclemia . AM J HUM GENET vol. 82 , ( 1 ) 139 - 149 .

Myint PK, Luben RN, Welch AA, Bingham SA, Wareham NJ, Khaw K-T ( 2008 ) . Plasma vitamin C concentrations predict risk of incident stroke over 10 y in 20 649 participants of the European Prospective Investigation into Cancer–Norfolk prospective population study . American Journal of Clinical Nutrition vol. 87 , ( 1 ) 64 - 69 .

Peters TM, Ekelund U, Leitzmann M, Easton D, Warren R, Luben R, Bingham S, Khaw K-T et al. ( 2007 ) . Physical Activity and Mammographic Breast Density in the EPIC-Norfolk Cohort Study . American Journal of Epidemiology vol. 167 , ( 5 ) 579 - 585 .

Myint PK, Surtees PG, Wainwright NWJ, Luben RN, Welch AA, Bingham SA, Wareham NJ, Khaw K-T ( 2007 ) . Physical health-related quality of life predicts stroke in the EPIC-Norfolk . Neurology vol. 69 , ( 24 ) 2243 - 2248 .

Canoy D, Boekholdt SM, Wareham N, Luben R, Welch A, Bingham S, Buchan I, Day N et al. ( 2007 ) . Body Fat Distribution and Risk of Coronary Heart Disease in Men and Women in the European Prospective Investigation Into Cancer and Nutrition in Norfolk Cohort . Circulation vol. 116 , ( 25 ) 2933 - 2943 .

Freel EM, Ingram M, Friel EC, Fraser R, Brown M, Samani NJ, Caulfield M, Munroe P et al. ( 2007 ) . Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study . CLIN ENDOCRINOL vol. 67 , ( 6 ) 832 - 838 .

Wallace C, Newhouse SJ, Braund P, Zhang F, Tobin M, Falchi M, Ahmadi K, Dobson RJ et al. ( 2007 ) . Discovery of novel genes for serum urate and low-density lipoprotein cholesterol - Two biomarkers of cardiovascular disease . CIRCULATION RESEARCH . vol. 101 , 1208 - 1208 .

Khaw K-T, Dowsett M, Folkerd E, Bingham S, Wareham N, Luben R, Welch A, Day N ( 2007 ) . Endogenous Testosterone and Mortality Due to All Causes, Cardiovascular Disease, and Cancer in Men . Circulation vol. 116 , ( 23 ) 2694 - 2701 .

Newhouse SJ, Wallace C, Hoti M, Dobson RJ, Farrall M, Brown M, Samani NJ, Dominiczak A et al. ( 2007 ) . Novel associations of the Wnk1 gene with risk for essential hypertension and electrolyte homeostasis . CIRCULATION RESEARCH . vol. 101 , 1208 - 1208 .

Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, Kwiatkowski DP, McCarthy MI et al. ( 2007 ) . Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A . Nature vol. 450 , ( 7171 ) 887 - 892 .

Thomson W, Barton A, Ke X, Eyre S, Hinks A, Bowes J, Donn R, Symmons D et al. ( 2007 ) . Rheumatoid arthritis association at 6q23 . Nature Genetics vol. 39 , ( 12 ) 1431 - 1433 .

HITMAN GA, Todd JA, Samani NJ, Ouwehand WH, Kwiatkowski DP, Deloukas P, Craddock N, Cardon LR et al. ( 2007 ) . Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants . Nat Genet vol. 39 , 129 - 1337 .

Wallace C, Dobson RJ, Munroe PB, Caulfield MJ ( 2007 ) . Information capture using SNPs from HapMap and whole-genome chips differs in a sample of inflammatory and cardiovascular gene-centric regions from genome-wide estimates . Genome Res vol. 17 , ( 11 ) 1596 - 1602 .

Myint PK, Luben RN, Wareham NJ, Welch AA, Bingham SA, Khaw K-T ( 2007 ) . Physical activity and fibrinogen concentrations in 23,201 men and women in the EPIC-Norfolk population-based study . Atherosclerosis vol. 198 , ( 2 ) 419 - 425 .

Barrett JC, Burton PR, Davison D, Donnelly P, Easton D, Evans DM, Leung H-T, Marchini JL et al. ( 2007 ) . Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants . Nature Genetics vol. 39 , ( 11 ) 1329 - 1337 .

Wu K, Bowman R, Welch AA, Luben RN, Wareham N, Khaw K-T, Bingham SA ( 2007 ) . Apolipoprotein E polymorphisms, dietary fat and fibre, and serum lipids: the EPIC Norfolk study . European Heart Journal vol. 28 , ( 23 ) 2930 - 2936 .

Arsenault BJ, Lemieux I, Després J-P, Wareham NJ, Luben R, Kastelein JJP, Khaw K-T, Boekholdt SM ( 2007 ) . Cholesterol levels in small LDL particles predict the risk of coronary heart disease in the EPIC-Norfolk prospective population study . European Heart Journal vol. 28 , ( 22 ) 2770 - 2777 .

Purslow LR, Sandhu MS, Forouhi N, Young EH, Luben RN, Welch AA, Khaw K-T, Bingham SA et al. ( 2007 ) . Energy Intake at Breakfast and Weight Change: Prospective Study of 6,764 Middle-aged Men and Women . American Journal of Epidemiology vol. 167 , ( 2 ) 188 - 192 .

Birjmohun RS, Dallinga-Thie GM, Kuivenhoven JA, Stroes ESG, Otvos JD, Wareham NJ, Luben R, Kastelein JJP et al. ( 2007 ) . Apolipoprotein A-II Is Inversely Associated With Risk of Future Coronary Artery Disease . Circulation vol. 116 , ( 18 ) 2029 - 2035 .

Freimer NB, Service SK, Ophoff RA, Jasinska AJ, McKee K, Villeneuve A, Belisle A, Bailey JN et al. ( 2007 ) . A quantitative trait locus for variation in dopamine metabolism mapped in a primate model using reference sequences from related species . Proceedings of the National Academy of Sciences of the United States of America vol. 104 , ( 40 ) 15811 - 15816 .

Padmanabhan S, Davies E, MacKenzie SM, Lim W, Barr M, Friel EC, Munroe PB, Brown MJ et al. ( 2007 ) . Association of the CYP11B1 and CYP11B2 gene polymorphisms with hypertension in the British Genetics of Hypertension case-control study . J HUM HYPERTENS vol. 21 , ( 10 ) 837 - 837 .

Newhouse S, Wallace C, Hoti M, Burke B, Marcano A, Onipinla A, Dobson R, Mein C et al. ( 2007 ) . Association of the WNK1 gene with essential hypertension, blood pressure variability and serum and urine electrolytes . J HUM HYPERTENS . vol. 21 , 831 - 831 .

Rana JS, Boekholdt SM, Ridker PM, Jukema JW, Luben R, Bingham SA, Day NE, Wareham NJ et al. ( 2007 ) . Differential leucocyte count and the risk of future coronary artery disease in healthy men and women: the EPIC‐Norfolk Prospective Population Study . Journal of Internal Medicine vol. 262 , ( 6 ) 678 - 689 .

Padmanabhan S, Menni C, Delles C, Munroe PB, Brown MJ, Samani NJ, Farrall M, Dobson R et al. ( 2007 ) . Urinary albumin excretion in hypertensive siblings in the British Genetics of Hypertension study . J HUM HYPERTENS . vol. 21 , 843 - 843 .

Freimer NB, Slatkin M ( 2007 ) . Microsatellites: Evolution and Mutational Processes . Novartis Foundation Symposia vol. 197 , 51 - 72 .

Wainwright NWJ, Surtees PG, Welch AA, Luben RN, Khaw K-T, Bingham SA ( 2007 ) . Healthy lifestyle choices: could sense of coherence aid health promotion? . Journal of Epidemiology & Community Health vol. 61 , ( 10 )

Athos EA, Levinson B, Kistler A, Zemansky J, Bostrom A, Freimer N, Gitschier J ( 2007 ) . Dichotomy and perceptual distortions in absolute pitch ability . Proceedings of the National Academy of Sciences of the United States of America vol. 104 , ( 37 ) 14795 - 14800 .

Marcano ACB, Burke B, Gungadoo J, Wallace C, Kaisaki PJ, Woon PY, Farrall M, Clayton D et al. ( 2007 ) . Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension . J MED GENET vol. 44 , ( 9 ) Article 603 ,

Bingham S, Luben R, Welch A, Tasevska N, Wareham N, Khaw KT ( 2007 ) . Epidemiologic Assessment of Sugars Consumption Using Biomarkers: Comparisons of Obese and Nonobese Individuals in the European Prospective Investigation of Cancer Norfolk . Cancer Epidemiology Biomarkers & Prevention vol. 16 , ( 8 ) 1651 - 1654 .

Jasinska AJ, Service S, Levinson M, Slaten E, Lee O, Sobel E, Fairbanks LA, Bailey JN et al. ( 2007 ) . A genetic linkage map of the vervet monkey (Chlorocebus aethiops sabaeus) . Mammalian Genome vol. 18 , ( 5 ) 347 - 360 .

Chan M-F, Dowsett M, Folkerd E, Wareham N, Luben R, Welch A, Bingham S, Khaw K-T ( 2007 ) . Past oral contraceptive and hormone therapy use and endogenous hormone concentrations in postmenopausal women . Menopause The Journal of The North American Menopause Society vol. 15 , ( 2 ) 332 - 339 .

Easton DF, Pooley KA, Dunning AM, Pharoah PDP, Thompson D, Ballinger DG, Struewing JP, Morrison J et al. ( 2007 ) . Genome-wide association study identifies novel breast cancer susceptibility loci . Nature vol. 447 , ( 7148 ) 1087 - 1093 .

Meuwese MC, Stroes ESG, Hazen SL, van Miert JN, Kuivenhoven JA, Schaub RG, Wareham NJ, Luben R et al. ( 2007 ) . Serum Myeloperoxidase Levels Are Associated With the Future Risk of Coronary Artery Disease in Apparently Healthy Individuals The EPIC-Norfolk Prospective Population Study . Journal of the American College of Cardiology vol. 50 , ( 2 ) 159 - 165 .

Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, Kwiatkowski DP, McCarthy MI et al. ( 2007 ) . Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls . NATURE vol. 447 , ( 7145 ) 661 - 678 .

( 2007 ) . Replicating genotype–phenotype associations . Nature vol. 447 , ( 7145 ) 655 - 660 .

Myint PK, Luben RN, Surtees PG, Wainwright NWJ, Welch AA, Bingham SA, Wareham NJ, Smith RD et al. ( 2007 ) . Self-Reported Mental Health-Related Quality of Life and Mortality in Men and Women in the European Prospective Investigation into Cancer (EPIC-Norfolk): A Prospective Population Study . Psychosomatic Medicine vol. 69 , ( 5 ) 410 - 414 .

Low Y-L, Dunning AM, Dowsett M, Folkerd E, Doody D, Taylor J, Bhaniani A, Luben R et al. ( 2007 ) . Phytoestrogen Exposure Is Associated with Circulating Sex Hormone Levels in Postmenopausal Women and Interact with ESR1 and NR1I2 Gene Variants . Cancer Epidemiology Biomarkers & Prevention vol. 16 , ( 5 ) 1009 - 1016 .

Chan M-F, Dowsett M, Folkerd E, Bingham S, Wareham N, Luben R, Welch A, Khaw K-T ( 2007 ) . Usual Physical Activity and Endogenous Sex Hormones in Postmenopausal Women: The European Prospective Investigation into Cancer–Norfolk Population Study . Cancer Epidemiology Biomarkers & Prevention vol. 16 , ( 5 ) 900 - 905 .

Heude B, Ong KK, Luben R, Wareham NJ, Sandhu MS ( 2007 ) . Study of Association between Common Variation in the Insulin-Like Growth Factor 2 Gene and Indices of Obesity and Body Size in Middle-Aged Men and Women . The Journal of Clinical Endocrinology & Metabolism vol. 92 , ( 7 ) 2734 - 2738 .

van der Steeg WA, Boekholdt SM, Stein EA, El-Harchaoui K, Stroes ESG, Sandhu MS, Wareham NJ, Jukema JW et al. ( 2007 ) . Role of the apolipoprotein B-apolipoprotein A-I ratio in cardiovascular risk assessment: a case-control analysis in EPIC-Norfolk . Annals of Internal Medicine vol. 146 , ( 9 ) 640 - 648 .

Baynes C, Healey CS, Pooley KA, Scollen S, Luben RN, Thompson DJ, Pharoah PD, Easton DF et al. ( 2007 ) . Common variants in the ATM, BRCA1, BRCA2, CHEK2 and TP53 cancer susceptibility genes are unlikely to increase breast cancer risk . Breast Cancer Research vol. 9 , ( 2 )

Samuelson DJ, Hesselson SE, Aperavich BA, Zan Y, Haag JD, Trentham-Dietz A, Hampton JM, Mau B et al. ( 2007 ) . Rat Mcs5a is a compound quantitative trait locus with orthologous human loci that associate with breast cancer risk . Proceedings of the National Academy of Sciences of the United States of America vol. 104 , ( 15 ) 6299 - 6304 .

Melzer D, Frayling TM, Murray A, Hurst AJ, Harries LW, Song H, Khaw K, Luben R et al. ( 2007 ) . A common variant of the p16INK4a genetic region is associated with physical function in older people . Mechanisms of Ageing and Development vol. 128 , ( 5-6 ) 370 - 377 .

Pharoah PDP, Tyrer J, Dunning AM, Easton DF, Ponder BAJ ( 2007 ) . Association between Common Variation in 120 Candidate Genes and Breast Cancer Risk . PLOS Genetics vol. 3 , ( 3 )

Surtees PG, Wainwright NWJ, Luben RL, Wareham NJ, Bingham SA, Khaw K-T ( 2007 ) . Adaptation to Social Adversity Is Associated With Stroke Incidence: Evidence From the EPIC-Norfolk Prospective Cohort Study . Stroke vol. 38 , ( 5 ) 1447 - 1453 .

Munroe P, O'Rawe A, Mitchison H, Järvelä I, Santavuori P, Lerner T, Taschner P, Gardiner R et al. ( 2007 ) . Strategy for Mutation Detection in CLN3: Characterisation of Two Finnish Mutations . Neuropediatrics vol. 28 , ( 01 ) 15 - 17 .

Mitchison H, Taschner P, Kremmidiotis C, Callen D, Doggett N, Lemer T, Janes R, Wallace B et al. ( 2007 ) . Structure of the CLN3 Gene and Predicted Structure, Location and Function of CLN3 Protein . Neuropediatrics vol. 28 , ( 01 ) 12 - 14 .

Boekholdt SM, Meuwese MC, Day NE, Luben R, Welch A, Wareham NJ, Khaw K-T ( 2007 ) . Plasma concentrations of ascorbic acid and C-reactive protein, and risk of future coronary artery disease, in apparently healthy men and women: the EPIC-Norfolk prospective population study . British Journal Of Nutrition vol. 96 , ( 3 ) 516 - 522 .

Forouhi NG, Harding AH, Allison M, Sandhu MS, Welch A, Luben R, Bingham S, Khaw KT et al. ( 2007 ) . Elevated serum ferritin levels predict new-onset type 2 diabetes: results from the EPIC-Norfolk prospective study . Diabetologia vol. 50 , ( 5 ) 949 - 956 .

Service S, Sabatti C, Freimer N ( 2007 ) . Tag SNPs chosen from HapMap perform well in several population isolates . Genetic Epidemiology vol. 31 , ( 3 ) 189 - 194 .

Mallat Z, Benessiano J, Simon T, Ederhy S, Sebella-Arguelles C, Cohen A, Huart V, Wareham NJ et al. ( 2007 ) . Circulating Secretory Phospholipase A2 Activity and Risk of Incident Coronary Events in Healthy Men and Women . Arteriosclerosis Thrombosis and Vascular Biology vol. 27 , ( 5 ) 1177 - 1183 .

Freimer NB, Sabatti C ( 2007 ) . Variants in common diseases . Nature vol. 445 , ( 7130 ) 828 - 829 .

Genetics TTSAICF ( 2007 ) . Genome Scan for Tourette Disorder in Affected-Sibling-Pair and Multigenerational Families . American Journal of Human Genetics vol. 80 , ( 2 ) 265 - 272 .

Myint PK, Sinha S, Wareham NJ, Bingham SA, Luben RN, Welch AA, Khaw K-T ( 2007 ) . Glycated Hemoglobin and Risk of Stroke in People Without Known Diabetes in the European Prospective Investigation Into Cancer (EPIC)–Norfolk Prospective Population Study . Stroke vol. 38 , ( 2 ) 271 - 275 .

Welch A, McTaggart A, Mulligan A, Luben R, Walker N, Khaw K, Day N, Bingham ( 2007 ) . DINER (Data Into Nutrients for Epidemiological Research) – a new data-entry program for nutritional analysis in the EPIC–Norfolk cohort and the 7-day diary method . Public Health Nutrition vol. 4 , ( 6 ) 1253 - 1265 .

Myint PK, Welch AA, Bingham SA, Luben RN, Wareham NJ, Day NE, Khaw K-T ( 2007 ) . Habitual fish consumption and risk of incident stroke: the European Prospective Investigation into Cancer (EPIC)–Norfolk prospective population study . Public Health Nutrition vol. 9 , ( 7 ) 882 - 888 .

Bingham SA, Welch AA, McTaggart A, Mulligan AA, Runswick SA, Luben R, Oakes S, Khaw KT et al. ( 2007 ) . Nutritional methods in the European Prospective Investigation of Cancer in Norfolk . Public Health Nutrition vol. 4 , ( 3 ) 847 - 858 .

Sieri S, Agudo A, Kesse E, Klipstein-Grobusch K, San-José B, Welch A, Krogh V, Luben R et al. ( 2007 ) . Patterns of alcohol consumption in 10 European countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) project . Public Health Nutrition vol. 5 , ( 6b ) 1287 - 1296 .

Welch A, Lund E, Amiano P, Dorronsoro M, Brustad M, Kumle M, Rodriguez M, Lasheras C et al. ( 2007 ) . Variability of fish consumption within the 10 European countries participating in the European Investigation into Cancer and Nutrition (EPIC) study . Public Health Nutrition vol. 5 , ( 6b ) 1273 - 1285 .

Burke B, Gungadoo J, Marçano ACB, Newhouse SJ, Shiel J, Caulfield MJ, Munroe PB ( 2007 ) . Chapter 36 Monogenic Forms of Human Hypertension . Comprehensive Hypertension , Elsevier

Myint PK, Welch AA, Bingham SA, Surtees PG, Wainwright NW, Luben RN, Wareham NJ, Smith RD et al. ( 2007 ) . Fruit and vegetable consumption and self-reported functional health in men and women in the European Prospective Investigation into Cancer–Norfolk (EPIC–Norfolk): a population-based cross-sectional study . Public Health Nutrition vol. 10 , ( 1 ) 34 - 41 .

Burke B, Gungadoo J, Marçano ACB, Newhouse SJ, Shiel J, Caulfield MJ, Munroe PB ( 2007 ) . Monogenic Forms of Human Hypertension . Comprehensive Hypertension ,

Barr M, MacKenzie SM, Friel EC, Holloway CD, Wilkinson DM, Brain NJR, Ingram MC, Fraser R et al. ( 2007 ) . Polymorphic variation in the 11 beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency . HYPERTENSION vol. 49 , ( 1 ) 113 - 119 .

CAULFIELD M, BOULOUX P, MUNROE P ( 1997 ) . Progress in Determining the Genes for Hypertension, Insulin Resistance, and Dyslipidemiaa . Annals of the New York Academy of Sciences . vol. 827 , 110 - 117 .

Wang H, Lin C-H, Service S, Chen Y, Freimer N, Sabatti C ( 2006 ) . Linkage Disequilibrium and Haplotype Homozygosity in Population Samples Genotyped at a High Marker Density . Human Heredity vol. 62 , ( 4 ) 175 - 189 .

( 2006 ) . CORRIGENDUM . Journal of Thrombosis and Haemostasis vol. 4 , ( 12 )

Raby BA, Soto-Quiros ME, Avila L, Lake SL, Murphy A, Liang C, Fournier E, Spesny M et al. ( 2006 ) . Sex-specific linkage to total serum immunoglobulin E in families of children with asthma in Costa Rica . Human Molecular Genetics vol. 16 , ( 3 ) 243 - 253 .

Benusiglio PR, Pharoah PD, Smith PL, Lesueur F, Conroy D, Luben RN, Dew G, Jordan C et al. ( 2006 ) . HapMap-based study of the 17q21 ERBB2 amplicon in susceptibility to breast cancer . British Journal of Cancer vol. 95 , ( 12 ) 1689 - 1695 .

Hersh CP, Soto-Quirós ME, Avila L, Lake SL, Liang C, Fournier E, Spesny M, Sylvia JS et al. ( 2006 ) . Genome-wide linkage analysis of pulmonary function in families of children with asthma in Costa Rica . Thorax vol. 62 , ( 3 )

Mehan MR, Almonte M, Slaten E, Freimer NB, Rao PN, Ophoff RA ( 2006 ) . Analysis of segmental duplications reveals a distinct pattern of continuation-of-synteny between human and mouse genomes . Human Genetics vol. 121 , ( 1 ) 93 - 100 .

Pinedo S, Vissers MN, von Bergmann K, Elharchaoui K, Lütjohann D, Luben R, Wareham NJ, Kastelein JJP et al. ( 2006 ) . Plasma levels of plant sterols and the risk of coronary artery disease: the prospective EPIC-Norfolk Population Study . Journal of Lipid Research vol. 48 , ( 1 ) 139 - 144 .

Myint PK, Luben RN, Wareham NJ, Welch AA, Bingham SA, Day NE, Khaw K-T ( 2006 ) . Combined Work and Leisure Physical Activity and Risk of Stroke in Men and Women in the European Prospective Investigation into Cancer-Norfolk Prospective Population Study . Neuroepidemiology vol. 27 , ( 3 ) 122 - 129 .

Myint PK, Surtees PG, Wainwright NWJ, Wareham NJ, Bingham SA, Luben RN, Welch AA, Smith RD et al. ( 2006 ) . Modifiable lifestyle behaviors and functional health in the European Prospective Investigation into Cancer (EPIC)-Norfolk population study . Preventive Medicine vol. 44 , ( 2 ) 109 - 116 .

Keen-Kim D, Mathews CA, Reus VI, Lowe TL, Herrera LD, Budman CL, Gross-Tsur V, Pulver AE et al. ( 2006 ) . Overrepresentation of rare variants in a specific ethnic group may confuse interpretation of association analyses . Human Molecular Genetics vol. 15 , ( 22 ) 3324 - 3328 .

Delles C, Braga-Marcano AC, Munroe PB, Padmanabhan S, McClure JD, Brain NJ, Brown MJ, Samani NJ et al. ( 2006 ) . Association between variants of the human GSTM gene family and hypertension . HYPERTENSION . vol. 48 , E27 - E27 .

Padmanabhan S, Hastie CE, Wallace C, Munroe PB, Dobson R, Brown M, Samani NJ, Clayton D et al. ( 2006 ) . Familial atherosclerotic disease and hypertension localised to chromosome 7p in the British genetics of hypertension study . HYPERTENSION . vol. 48 , E98 - E98 .

Celedón JC, Soto-Quiros ME, Avila L, Lake SL, Liang C, Fournier E, Spesny M, Hersh CP et al. ( 2006 ) . Significant linkage to airway responsiveness on chromosome 12q24 in families of children with asthma in Costa Rica . Human Genetics vol. 120 , ( 5 ) 691 - 699 .

Herzberg I, Jasinska A, García J, Jawaheer D, Service S, Kremeyer B, Duque C, Parra MV et al. ( 2006 ) . Convergent linkage evidence from two Latin-American population isolates supports the presence of a susceptibility locus for bipolar disorder in 5q31–34 . Human Molecular Genetics vol. 15 , ( 21 ) 3146 - 3153 .

Low Y-L, Dunning AM, Dowsett M, Luben RN, Khaw K-T, Wareham NJ, Bingham SA ( 2006 ) . Implications of Gene-Environment Interaction in Studies of Gene Variants in Breast Cancer: An Example of Dietary Isoflavones and the D356N Polymorphism in the Sex Hormone-Binding Globulin Gene . Cancer Research vol. 66 , ( 18 ) 8980 - 8983 .

Kerner B, Brugman DL, Freimer NB ( 2006 ) . Evidence of linkage to psychosis on chromosome 5q33‐34 in pedigrees ascertained for bipolar disorder . American Journal of Medical Genetics Part B Neuropsychiatric Genetics vol. 144B , ( 1 ) 74 - 78 .

Low Y-L, Taylor JI, Grace PB, Mulligan AA, Welch AA, Scollen S, Dunning AM, Luben RN et al. ( 2006 ) . Phytoestrogen Exposure, Polymorphisms in COMT, CYP19, ESR1, and SHBG Genes, and Their Associations With Prostate Cancer Risk . Nutrition and Cancer vol. 56 , ( 1 ) 31 - 39 .

Keller TT, Choi D, Nagel C, Te Velthuis H, Gerdes VEA, Wareham NJ, Bingham SA, Luben R et al. ( 2006 ) . Tissue factor serum levels and the risk of future coronary artery disease in apparently healthy men and women: the EPIC‐Norfolk prospective population study . Journal of Thrombosis and Haemostasis vol. 4 , ( 11 ) 2391 - 2396 .

Keller TT, van Leuven SI, Meuwese MC, Wareham NJ, Luben R, Stroes ES, Hack CE, Levi M et al. ( 2006 ) . Serum Levels of Mannose-Binding Lectin and the Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women . Arteriosclerosis Thrombosis and Vascular Biology vol. 26 , ( 10 ) 2345 - 2350 .

Warren R, Skinner J, Sala E, Denton E, Dowsett M, Folkerd E, Healey CS, Dunning A et al. ( 2006 ) . Associations among Mammographic Density, Circulating Sex Hormones, and Polymorphisms in Sex Hormone Metabolism Genes in Postmenopausal Women . Cancer Epidemiology Biomarkers & Prevention vol. 15 , ( 8 ) 1502 - 1508 .

BOEKHOLDT SM, SANDHU MS, WAREHAM NJ, LUBEN R, REITSMA PH, KHAW K ( 2006 ) . Fibrinogen plasma levels modify the association between the factor XIII Val34Leu variant and risk of coronary artery disease: the EPIC‐Norfolk prospective population study . Journal of Thrombosis and Haemostasis vol. 4 , ( 10 ) 2204 - 2209 .

Keen-Kim D, Freimer NB ( 2006 ) . Genetics and Epidemiology of Tourette Syndrome . Journal of Child Neurology vol. 21 , ( 8 ) 665 - 671 .

Wallace C, Xue M-Z, Newhouse SJ, Marcano ACB, Onipinla AK, Burke B, Gungadoo J, Dobson RJ et al. ( 2006 ) . Linkage analysis using co-phenotypes in the BRIGHT study reveals novel potential susceptibility loci for hypertension . Am J Hum Genet vol. 79 , ( 2 ) 323 - 331 .

Surtees PG, Wainwright NWJ, Willis-Owen SAG, Sandhu MS, Luben R, Day NE, Flint J ( 2006 ) . The brain-derived neurotrophic factor Val66Met polymorphism is associated with sense of coherence in a non-clinical community sample of 7335 adults . Journal of Psychiatric Research vol. 41 , ( 8 ) 707 - 710 .

Kataoka M, Warren R, Luben R, Camus J, Denton E, Sala E, Day N, Khaw K-T ( 2006 ) . How predictive is breast arterial calcification of cardiovascular disease and risk factors when found at screening mammography? . American Journal of Roentgenology vol. 187 , ( 1 ) 73 - 80 .

Munroe PB, Wallace C, Xue M-Z, Marçano ACB, Dobson RJ, Onipinla AK, Burke B, Gungadoo J et al. ( 2006 ) . Increased support for linkage of a novel locus on chromosome 5q13 for essential hypertension in the British Genetics of Hypertension Study . Hypertension vol. 48 , ( 1 ) 105 - 111 .

Vaessen SFC, Schaap FG, Kuivenhoven J-A, Groen AK, Hutten BA, Boekholdt SM, Hattori H, Sandhu MS et al. ( 2006 ) . Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study . Journal of Lipid Research vol. 47 , ( 9 ) 2064 - 2070 .

Mathews CA, Bimson B, Lowe TL, Herrera LD, Budman CL, Erenberg G, Naarden A, Bruun RD et al. ( 2006 ) . Association Between Maternal Smoking and Increased Symptom Severity in Tourettes Syndrome . American Journal of Psychiatry vol. 163 , ( 6 ) 1066 - 1073 .

Padmanabhan S, Wallace C, McBride MW, Munroe PB, Dobson R, Brown M, Samani NJ, Clayton D et al. ( 2006 ) . Genomewide linkage analysis for loci affecting electrocardiographic LV mass . JOURNAL OF HYPERTENSION . vol. 24 , S330 - S330 .

Delles C, Marcano ACB, Munroe PB, Padmanabhan S, McClure JD, Brain NJ, Brown MJ, Samani NJ et al. ( 2006 ) . Variants of the human mu type glutathione-s-transferase (GSTM) gene family are associated with hypertension . JOURNAL OF HYPERTENSION . vol. 24 , S13 - S13 .

Khaw K-T, Jakes R, Bingham S, Welch A, Luben R, Day N, Wareham N ( 2006 ) . Work and leisure time physical activity assessed using a simple, pragmatic, validated questionnaire and incident cardiovascular disease and all-cause mortality in men and women: The European Prospective Investigation into Cancer in Norfolk prospective population study . International Journal of Epidemiology vol. 35 , ( 4 ) 1034 - 1043 .

Bearden CE, Freimer NB ( 2006 ) . Endophenotypes for psychiatric disorders: ready for primetime? . Trends in Genetics vol. 22 , ( 6 ) 306 - 313 .

Woods RP, Freimer NB, De Young JA, Fears SC, Sicotte NL, Service SK, Valentino DJ, Toga AW et al. ( 2006 ) . Normal variants of Microcephalin and ASPM do not account for brain size variability . Human Molecular Genetics vol. 15 , ( 12 ) 2025 - 2029 .

Lesueur F, Song H, Ahmed S, Luccarini C, Jordan C, Luben R, Easton DF, Dunning AM et al. ( 2006 ) . Single-nucleotide polymorphisms in the RB1 gene and association with breast cancer in the British population . British Journal of Cancer vol. 94 , ( 12 ) 1921 - 1926 .

Service S, Molina J, Deyoung J, Jawaheer D, Aldana I, Vu T, Araya C, Araya X et al. ( 2006 ) . Results of a SNP genome screen in a large Costa Rican pedigree segregating for severe bipolar disorder . American Journal of Medical Genetics Part B Neuropsychiatric Genetics vol. 141B , ( 4 ) 367 - 373 .

Dobson RJ, Munroe PB, Caulfield MJ, Saqi MA ( 2006 ) . Predicting deleterious nsSNPs: an analysis of sequence and structural attributes . BMC Bioinformatics vol. 7 ,

Bell JT, Wallace C, Dobson R, Wiltshire S, Mein C, Pembroke J, Brown M, Clayton D et al. ( 2006 ) . Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension . HUM MOL GENET vol. 15 , ( 8 ) 1365 - 1374 .

Mathews CA, Jang KL, Herrera LD, Lowe TL, Budman CL, Erenberg G, Naarden A, Bruun RD et al. ( 2006 ) . Tic Symptom Profiles in Subjects with Tourette Syndrome from two Genetically Isolated Populations . Biological Psychiatry vol. 61 , ( 3 ) 292 - 300 .

Service S, DeYoung J, Karayiorgou M, Roos JL, Pretorious H, Bedoya G, Ospina J, Ruiz-Linares A et al. ( 2006 ) . Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies . Nature Genetics vol. 38 , ( 5 ) 556 - 560 .

Jakszyn P, Bingham S, Pera G, Agudo A, Luben R, Welch A, Boeing H, Del Giudice G et al. ( 2006 ) . Endogenous versus exogenous exposure to N -nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study . Carcinogenesis vol. 27 , ( 7 ) 1497 - 1501 .

Glatt C, Almonte M, Taylor T, Edwards RH, Freimer N, Tanner C, Group TPS ( 2006 ) . Structural variants in the vesicular monoamine transporter do not contribute to sporadic Parkinson's disease . Movement Disorders vol. 21 , ( 3 ) 426 - 427 .

Padmanabhan S, Wallace C, Munroe PB, Dobson R, Brown M, Samani N, Clayton D, Farrall M et al. ( 2006 ) . Chromosome 2p shows significant linkage to antihypertensive response in the British Genetics of Hypertension Study . Hypertension . vol. 47 , 603 - 608 .

Padmanabhan S, Wallace C, Munroe PB, Dobson R, Brown M, Samani N, Clayton D, Farrall M et al. ( 2006 ) . Chromosome 2p shows significant linkage to antihypertensive response in the British genetics of hypertension study . HYPERTENSION . vol. 47 , 603 - 608 .

Binder A, Garcia E, Wallace C, Kazeem G, Ben-Shlomo Y, Yarnell J, Brown P, Caulfield M et al. ( 2006 ) . Haplotypes of the beta-2 adrenergic receptor associate with high diastolic blood pressure in the Caerphilly prospective study . J HYPERTENS vol. 24 , ( 3 ) 471 - 477 .

Cebrian A, Pharoah PD, Ahmed S, Ropero S, Fraga MF, Smith PL, Conroy D, Luben R et al. ( 2006 ) . Genetic variants in epigenetic genes and breast cancer risk . Carcinogenesis vol. 27 , ( 8 ) 1661 - 1669 .

Surtees PG, Wainwright NWJ, Willis-Owen SAG, Sandhu MS, Luben R, Day NE, Flint J ( 2006 ) . No association between the BDNF Val66Met polymorphism and mood status in a non-clinical community sample of 7389 older adults . Journal of Psychiatric Research vol. 41 , ( 5 ) 404 - 409 .

Patel BD, Welch AA, Bingham SA, Luben RN, Day NE, Khaw K-T, Lomas DA, Wareham NJ ( 2006 ) . Dietary antioxidants and asthma in adults . Thorax vol. 61 , ( 5 )

Myint PK, Luben RN, Welch AA, Bingham SA, Wareham NJ, Khaw K-T ( 2006 ) . Effect of Age on the Relationship of Occupational Social Class with Prevalence of Modifiable Cardiovascular Risk Factors and Cardiovascular Diseases . Gerontology vol. 52 , ( 1 ) 51 - 58 .

Canoy D, Wareham N, Luben R, Welch A, Bingham S, Day N, Khaw K-T ( 2006 ) . Serum lipid concentration in relation to anthropometric indices of central and peripheral fat distribution in 20,021 British men and women: Results from the EPIC-Norfolk population-based cohort study . Atherosclerosis vol. 189 , ( 2 ) 420 - 427 .

Cebrian A, Pharoah PD, Ahmed S, Smith PL, Luccarini C, Luben R, Redman K, Munday H et al. ( 2006 ) . Tagging Single-Nucleotide Polymorphisms in Antioxidant Defense Enzymes and Susceptibility to Breast Cancer . Cancer Research vol. 66 , ( 2 ) 1225 - 1233 .

Myint PK, Welch AA, Bingham SA, Luben RN, Wareham NJ, Day NE, Khaw K-T ( 2006 ) . Smoking predicts long-term mortality in stroke: The European Prospective Investigation into Cancer (EPIC)-Norfolk prospective population study . Preventive Medicine vol. 42 , ( 2 ) 128 - 131 .

Surtees PG, Wainwright NWJ, Luben R, Khaw K-T, Day NE ( 2006 ) . Mastery, Sense of Coherence, and Mortality: Evidence of Independent Associations From the EPIC-Norfolk Prospective Cohort Study . Health Psychology vol. 25 , ( 1 ) 102 - 110 .

Al-Zahrani A, Sandhu MS, Luben RN, Thompson D, Baynes C, Pooley KA, Luccarini C, Munday H et al. ( 2005 ) . IGF1 and IGFBP3 tagging polymorphisms are associated with circulating levels of IGF1, IGFBP3 and risk of breast cancer . Human Molecular Genetics vol. 15 , ( 1 ) 1 - 10 .

Rip J, Nierman MC, Wareham NJ, Luben R, Bingham SA, Day NE, van Miert JNI, Hutten BA et al. ( 2005 ) . Serum Lipoprotein Lipase Concentration and Risk for Future Coronary Artery Disease . Arteriosclerosis Thrombosis and Vascular Biology vol. 26 , ( 3 ) 637 - 642 .

Jarvik LF, La Rue A, Gokhman I, Harrison T, Holt L, Steh B, Harker J, Larson S et al. ( 2005 ) . Middle-Aged Children of Alzheimer Parents, A Pilot Study: Stable Neurocognitive Performance at 20-Year Follow-up . Journal of Geriatric Psychiatry and Neurology . vol. 18 , 187 - 191 .

Canoy D, Wareham N, Welch A, Bingham S, Luben R, Day N, Khaw K-T ( 2005 ) . Plasma ascorbic acid concentrations and fat distribution in 19 068 British men and women in the European Prospective Investigation into Cancer and Nutrition Norfolk cohort study 2 . American Journal of Clinical Nutrition vol. 82 , ( 6 ) 1203 - 1209 .

( 2005 ) . “Respiratory function and self-reported functional health: EPIC-Norfolk population study”. P.K. Myint, R.N. Luben, P.G. Surtees, N.W.J. Wainwright, A.A. Welch, S.A. Bingham, N.J. Wareham, N.E. Day and K-T. Khaw. Eur Respir J 2005; 26: 494–502 . European Respiratory Journal vol. 26 , ( 6 ) 1191 - 1191 .

Tobin MD, Raleigh SM, Newhouse S, Braund P, Bodycote C, Ogleby J, Cross D, Gracey J et al. ( 2005 ) . Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population . CIRCULATION vol. 112 , ( 22 ) 3423 - 3429 .

Padmanabhan S, Wallace C, Munroe PB, Brown M, Samani N, Clayton D, Farrall M, Webster J et al. ( 2005 ) . Chromosome 2p shows genome wide significant linkage to of anti-hypertensive medication response in the British genetics of hypertension (BRIGHT) study . HYPERTENSION . vol. 46 , 886 - 886 .

Wallace C, Xue MZ, Dobson R, Marcano C, Gungadoo J, Burke B, Onipinla A, Newhouse S et al. ( 2005 ) . Loci on chromosomes 5p and 20q are linked to multiple hypertension phenotypes in the BRItish genetics of Hypertension (BRIGHT) study . HYPERTENSION . vol. 46 , 877 - 877 .

Low Y-L, Taylor JI, Grace PB, Dowsett M, Folkerd E, Doody D, Dunning AM, Scollen S et al. ( 2005 ) . Polymorphisms in the CYP19 Gene May Affect the Positive Correlations between Serum and Urine Phytoestrogen Metabolites and Plasma Androgen Concentrations in Men 1 . Journal of Nutrition vol. 135 , ( 11 ) 2680 - 2686 .

Boekholdt SM, Hack CE, Sandhu MS, Luben R, Bingham SA, Wareham NJ, Peters RJG, Jukema JW et al. ( 2005 ) . C-reactive protein levels and coronary artery disease incidence and mortality in apparently healthy men and women: The EPIC-Norfolk prospective population study 1993–2003 . Atherosclerosis vol. 187 , ( 2 ) 415 - 422 .

Padmanabhan S, Munroe PB, Brown M, Clayton D, Farrall M, Webster J, Lathrop M, Caulfield M et al. ( 2005 ) . Chromosome 2p shows genome wide significant linkage to anti-hypertensive medication response in the British genetics hypertension (BRIGHT) study . HYPERTENSION . vol. 46 , 886 - 886 .

Munroe PB, Wallace C, Mein C, Dobson R, Xue M, Marcano C, Burke B, Gungadoo J et al. ( 2005 ) . Enhanced support for linkage to chromosome 5q13.1 and hypertension in the British Genetics of Hypertension (BRIGHT) study . HYPERTENSION . vol. 46 , 892 - 892 .

Wallace C, Xue MZ, Dobson R, Marcano C, Gungadoo J, Burke B, Onipinla A, Newhouse S et al. ( 2005 ) . Loci on chromosomes 5p and 20q are linked to multiple hypertension phenotypes in the BRItish Genetics of HyperTension (BRIGHT) study . HYPERTENSION . vol. 46 , 877 - 877 .

Xue MZ, Wallace C, Dobson R, Garcia E, Kazeem G, Gardener G, Needham E, Mattu R et al. ( 2005 ) . Variants and haplotypes of the angiotensinogen gene are associated with hypertension in the Caerphilly Prospective Study . HYPERTENSION . vol. 46 , 904 - 904 .

Surtees PG, Wainwright NWJ, Willis-Owen SAG, Luben R, Day NE, Flint J ( 2005 ) . Social Adversity, the Serotonin Transporter (5-HTTLPR) Polymorphism and Major Depressive Disorder . Biological Psychiatry vol. 59 , ( 3 ) 224 - 229 .

Freimer NB, Sabatti C ( 2005 ) . Guidelines for association studies in Human Molecular Genetics . Human Molecular Genetics vol. 14 , ( 17 ) 2481 - 2483 .

Sandhu MS, Heude B, Young EH, Luben R, Luan J, Khaw K-T, Todd J, Wareham NJ ( 2005 ) . INS VNTR Class Genotype and Indexes of Body Size and Obesity Population-Based Studies of 7,999 Middle-Aged Men and Women . Diabetes vol. 54 , ( 9 ) 2812 - 2815 .

Myint PK, Luben RN, Surtees PG, Wainwright NWJ, Welch AA, Bingham SA, Wareham NJ, Day NE et al. ( 2005 ) . Respiratory function and self-reported functional health: EPIC-Norfolk population study . European Respiratory Journal vol. 26 , ( 3 ) 494 - 502 .

Ishihara LS, Khaw K-T, Luben R, Bingham S, Welch A, Day N, Brayne C ( 2005 ) . Self-reported parkinsonian symptoms in the EPIC-Norfolk cohort . BMC Neurology vol. 5 , ( 1 )

Cebrian A, Lesueur F, Martin S, Leyland J, Ahmed S, Luccarini C, Smith PL, Luben R et al. ( 2005 ) . Polymorphisms in the Initiators of RET (Rearranged during Transfection) Signaling Pathway and Susceptibility to Sporadic Medullary Thyroid Carcinoma . The Journal of Clinical Endocrinology & Metabolism vol. 90 , ( 11 ) 6268 - 6274 .

Benusiglio PR, Lesueur F, Luccarini C, McIntosh J, Luben RN, Smith P, Dunning A, Easton DF et al. ( 2005 ) . Common variation in EMSYand risk of breast and ovarian cancer: a case-control study using HapMap tagging SNPs . BMC Cancer vol. 5 , ( 1 )

Jenab M, Bingham S, Ferrari P, Friesen MD, Al-Delaimy WK, Luben R, Wareham N, Khaw K-T et al. ( 2005 ) . Long-term Cryoconservation and Stability of Vitamin C in Serum Samples of the European Prospective Investigation into Cancer and Nutrition . Cancer Epidemiology Biomarkers & Prevention vol. 14 , ( 7 ) 1837 - 1840 .

( 2005 ) . Epidemiology of Hypertension . Hypertension , Taylor & Francis

Lesueur F, Pharoah PD, Laing S, Ahmed S, Jordan C, Smith PL, Luben R, Wareham NJ et al. ( 2005 ) . Allelic association of the human homologue of the mouse modifier Ptprj with breast cancer . Human Molecular Genetics vol. 14 , ( 16 ) 2349 - 2356 .

Myint PK, Luben RN, Surtees PG, Wainwright NWJ, Welch AA, Bingham SA, Day NE, Wareham NJ et al. ( 2005 ) . Relation Between Self-Reported Physical Functional Health and Chronic Disease Mortality in Men And Women in the European Prospective Investigation Into Cancer (EPIC–Norfolk): A Prospective Population Study . Annals of Epidemiology vol. 16 , ( 6 ) 492 - 500 .

Newhouse SJ, Wallace C, Dobson R, Mein C, Pembroke J, Farrall M, Clayton D, Brown M et al. ( 2005 ) . Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study . Hum Mol Genet vol. 14 , ( 13 ) 1805 - 1814 .

Marcano ACB, Onipinla AK, Caulfield MJ, Munroe PB ( 2005 ) . Recent advances in the identification of genes for human hypertension . Expert Rev Cardiovasc Ther vol. 3 , ( 4 ) 733 - 741 .

Munroe PB, Mitchison HM, Dooley TP, Gardiner RM, Mole SE ( 1995 ) . Analysis of Batten disease candidate genes STP and STM . American Journal of Medical Genetics . vol. 57 , 324 - 326 .

Michels KB, Welch AA, Luben R, Bingham SA, Day NE ( 2005 ) . Measurement of Fruit and Vegetable Consumption with Diet Questionnaires and Implications for Analyses and Interpretation . American Journal of Epidemiology vol. 161 , ( 10 ) 987 - 994 .

Sinha S, Luben RN, Welch A, Bingham S, Wareham NJ, Day NE, Khaw K-T ( 2005 ) . Fibrinogen and cigarette smoking in men and women in the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) population . European Journal of Preventive Cardiology vol. 12 , ( 2 ) 144 - 150 .

Surtees PG, Wainwright NWJ, Luben R, Day NE, Khaw K-T ( 2005 ) . Prospective cohort study of hostility and the risk of cardiovascular disease mortality . International Journal of Cardiology vol. 100 , ( 1 ) 155 - 161 .

Welch AA, Luben R, Khaw KT, Bingham SA ( 2005 ) . The CAFE computer program for nutritional analysis of the EPIC‐Norfolk food frequency questionnaire and identification of extreme nutrient values . Journal of Human Nutrition and Dietetics vol. 18 , ( 2 ) 99 - 116 .

Hu SP, Day NE, Li DR, Luben RN, Cai KL, Ou-Yang T, Li B, Lu XZ et al. ( 2005 ) . Further evidence for an HLA-related recessive mutation in nasopharyngeal carcinoma among the Chinese . British Journal of Cancer vol. 92 , ( 5 ) 967 - 970 .

Boekholdt SM, Keller TT, Wareham NJ, Luben R, Bingham SA, Day NE, Sandhu MS, Jukema JW et al. ( 2005 ) . Serum Levels of Type II Secretory Phospholipase A2 and the Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women . Arteriosclerosis Thrombosis and Vascular Biology vol. 25 , ( 4 ) 839 - 846 .

Low Y-L, Taylor JI, Grace PB, Dowsett M, Scollen S, Dunning AM, Mulligan AA, Welch AA et al. ( 2005 ) . Phytoestrogen Exposure Correlation with Plasma Estradiol in Postmenopausal Women in European Prospective Investigation of Cancer and Nutrition-Norfolk May Involve Diet-Gene Interactions . Cancer Epidemiology Biomarkers & Prevention vol. 14 , ( 1 ) 213 - 220 .

De Castro F, Moron FJ, Montoro L, Galan JJ, Real LM, Ruiz A ( 2005 ) . Re: Polymorphisms Associated With Circulating Sex Hormone Levels in Postmenopausal Women . Journal of the National Cancer Institute vol. 97 , ( 2 ) 152 - 153 .

Mein CA, Caulfield MJ, Munroe PB ( 2005 ) . Selection of candidate genes in hypertension . vol. 108 ,

Pattison DJ, Symmons DPM, Lunt M, Welch A, Luben R, Bingham SA, Khaw K, Day NE et al. ( 2004 ) . Dietary risk factors for the development of inflammatory polyarthritis: Evidence for a role of high level of red meat consumption . Arthritis & Rheumatism vol. 50 , ( 12 ) 3804 - 3812 .

Munroe PB, Dobson R, Pembroke J, Wilson S, Pheby J, Colville-Stewart S, Gilmour K, Macdade M et al. ( 2004 ) . The MRC BRIGHT study: Demographic and biochemical characteristics of the sibling-pair resource . BRITISH JOURNAL OF CLINICAL PHARMACOLOGY . vol. 58 , 688 - 688 .

Khaw K-T, Bingham S, Welch A, Luben R, O'Brien E, Wareham N, Day N ( 2004 ) . Blood pressure and urinary sodium in men and women: the Norfolk Cohort of the European Prospective Investigation into Cancer (EPIC-Norfolk) . American Journal of Clinical Nutrition vol. 80 , ( 5 ) 1397 - 1403 .

Canoy D, Luben R, Welch A, Bingham S, Wareham N, Day N, Khaw K-T ( 2004 ) . Fat distribution, body mass index and blood pressure in 22 090 men and women in the Norfolk cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Norfolk) study . Journal of Hypertension vol. 22 , ( 11 ) 2067 - 2074 .

Lee YW, Oh VMS, Garcia E, Taylor EA, Wu HM, Yap EPH, Kazeem GR, Caulfield MJ et al. ( 2004 ) . Haplotypes of the beta 2-adrenegic receptor gene are associated with essential hypertension in a Singaporean Chinese population . J HYPERTENS vol. 22 , ( 11 ) 2111 - 2116 .

DiCioccio RA, Song H, Waterfall C, Kimura MT, Nagase H, McGuire V, Hogdall E, Shah MN et al. ( 2004 ) . STK15 Polymorphisms and Association with Risk of Invasive Ovarian Cancer . Cancer Epidemiology Biomarkers & Prevention vol. 13 , ( 10 ) 1589 - 1594 .

Freimer N, Sabatti C ( 2004 ) . The use of pedigree, sib-pair and association studies of common diseases for genetic mapping and epidemiology . Nature Genetics vol. 36 , ( 10 ) 1045 - 1051 .

Khaw K-T, Wareham N, Bingham S, Luben R, Welch A, Day N ( 2004 ) . Association of hemoglobin A1c with cardiovascular disease and mortality in adults: the European prospective investigation into cancer in Norfolk . Annals of Internal Medicine vol. 141 , ( 6 ) 413 - 420 .

Boekholdt SM, Peters RJG, Day NE, Luben R, Bingham SA, Wareham NJ, Hack CE, Reitsma PH et al. ( 2004 ) . Macrophage migration inhibitory factor and the risk of myocardial infarction or death due to coronary artery disease in adults without prior myocardial infarction or stroke: The EPIC-Norfolk Prospective Population study . The American Journal of Medicine vol. 117 , ( 6 ) 390 - 397 .

Burman J, Tran CH, Glatt C, Freimer NB, Edwards RH ( 2004 ) . The effect of rare human sequence variants on the function of vesicular monoamine transporter 2 . Pharmacogenetics and Genomics vol. 14 , ( 9 ) 587 - 594 .

Boekholdt SM, Kuivenhoven J-A, Wareham NJ, Peters RJG, Jukema JW, Luben R, Bingham SA, Day NE et al. ( 2004 ) . Plasma Levels of Cholesteryl Ester Transfer Protein and the Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women . Circulation vol. 110 , ( 11 ) 1418 - 1423 .

Jakes RW, Day NE, Luben R, Welch A, Bingham S, Mitchell J, Hennings S, Rennie K et al. ( 2004 ) . Adjusting for energy intake—what measure to use in nutritional epidemiological studies? . International Journal of Epidemiology vol. 33 , ( 6 ) 1382 - 1386 .

Day NE, Wong MY, Bingham S, Khaw KT, Luben R, Michels KB, Welch A, Wareham NJ ( 2004 ) . Correlated measurement error—implications for nutritional epidemiology . International Journal of Epidemiology vol. 33 , ( 6 ) 1373 - 1381 .

Mehan MR, Freimer NB, Ophoff RA ( 2004 ) . A genome-wide survey of segmental duplications that mediate common human genetic variation of chromosomal architecture . Human Genomics vol. 1 , ( 5 )

Patel BD, Luben RN, Welch AA, Bingham SA, Khaw K-T, Day NE, Lomas DA, Wareham NJ ( 2004 ) . Childhood smoking is an independent risk factor for obstructive airways disease in women . Thorax vol. 59 , ( 8 )

Mathews CA, Waller J, Glidden D, Lowe TL, Herrera LD, Budman CL, Erenberg G, Naarden A et al. ( 2004 ) . Self injurious behaviour in Tourette syndrome: correlates with impulsivity and impulse control . Journal of Neurology Neurosurgery & Psychiatry vol. 75 , ( 8 )

Shohaimi S, Welch A, Bingham S, Luben R, Day N, Wareham N, Khaw K-T ( 2004 ) . Residential area deprivation predicts fruit and vegetable consumption independently of individual educational level and occupational social class: a cross sectional population study in the Norfolk cohort of the European Prospective Investigation into Cancer (EPIC-Norfolk) . Journal of Epidemiology & Community Health vol. 58 , ( 8 )

Miettunen J, Kantojärvi L, Ekelund J, Veijola J, Karvonen JT, Peltonen L, Järvelin MR, Freimer N et al. ( 2004 ) . A large population cohort provides normative data for investigation of temperament . Acta Psychiatrica Scandinavica vol. 110 , ( 2 ) 150 - 157 .

Shohaimi S, Welch A, Bingham S, Luben R, Day N, Wareham N, Khaw K ( 2004 ) . Area deprivation predicts lung function independently of education and social class . European Respiratory Journal vol. 24 , ( 1 ) 157 - 161 .

Michels KB, Bingham SA, Luben R, Welch AA, Day NE ( 2004 ) . The Effect of Correlated Measurement Error in Multivariate Models of Diet . American Journal of Epidemiology vol. 160 , ( 1 ) 59 - 67 .

Klomp LWJ, Vargas JC, van Mil SWC, Pawlikowska L, Strautnieks SS, van Eijk MJT, Juijn JA, Pabón‐Peña C et al. ( 2004 ) . Characterization of mutations in ATP8B1 associated with hereditary cholestasis . Hepatology vol. 40 , ( 1 ) 27 - 38 .

Dunning AM, Dowsett M, Healey CS, Tee L, Luben RN, Folkerd E, Novik KL, Kelemen L et al. ( 2004 ) . Polymorphisms Associated With Circulating Sex Hormone Levels in Postmenopausal Women . Journal of the National Cancer Institute vol. 96 , ( 12 ) 936 - 945 .

Macleod J, Smith GD, Lynch J ( 2004 ) . RE: “SENSE OF COHERENCE AND MORTALITY IN MEN AND WOMEN IN THE EPIC-NORFOLK UNITED KINGDOM PROSPECTIVE COHORT STUDY” . American Journal of Epidemiology vol. 159 , ( 12 ) 1202 - 1203 .

Tjønneland AM, Overvad K, Bingham SA, Day NE, Luben R, Ferrari P, Slimani N, Norat T et al. ( 2004 ) . Dietary fibers in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study . Ugeskrift for Laeger vol. 166 , ( 25 ) 2458 - 2460 .

Pattison DJ, Silman AJ, Goodson NJ, Lunt M, Bunn D, Luben R, Welch A, Bingham S et al. ( 2004 ) . Vitamin C and the risk of developing inflammatory polyarthritis: prospective nested case-control study . Annals of the Rheumatic Diseases vol. 63 , ( 7 )

Canoy D, Luben R, Welch A, Bingham S, Wareham N, Day N, Khaw KT ( 2004 ) . Abdominal Obesity and Respiratory Function in Men and Women in the EPIC-Norfolk Study, United Kingdom . American Journal of Epidemiology vol. 159 , ( 12 ) 1140 - 1149 .

Khaw K-T, Wareham N, Bingham S, Luben R, Welch A, Day N ( 2004 ) . Preliminary Communication: Glycated Hemoglobin, Diabetes, and Incident Colorectal Cancer in Men and Women: A Prospective Analysis from the European Prospective Investigation into Cancer–Norfolk Study . Cancer Epidemiology Biomarkers & Prevention vol. 13 , ( 6 ) 915 - 919 .

Boekholdt SM, Peters RJG, Hack CE, Day NE, Luben R, Bingham SA, Wareham NJ, Reitsma PH et al. ( 2004 ) . IL-8 Plasma Concentrations and the Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women . Arteriosclerosis Thrombosis and Vascular Biology vol. 24 , ( 8 ) 1503 - 1508 .

Newhouse S, Dobson R, Wallace C, Pembroke J, Garcia E, Mein C, Clayton D, Samani N et al. ( 2004 ) . No association of the WNK1 gene with essential hypertension in the MRC BRIGHT study . JOURNAL OF HYPERTENSION . vol. 22 , S212 - S212 .

Bearden CE, Reus VI, Freimer NB ( 2004 ) . Why genetic investigation of psychiatric disorders is so difficult . Current Opinion in Genetics & Development vol. 14 , ( 3 ) 280 - 286 .

Grace PB, Taylor JI, Low Y-L, Luben RN, Mulligan AA, Botting NP, Dowsett M, Welch AA et al. ( 2004 ) . Phytoestrogen Concentrations in Serum and Spot Urine as Biomarkers for Dietary Phytoestrogen Intake and Their Relation to Breast Cancer Risk in European Prospective Investigation of Cancer and Nutrition-Norfolk . Cancer Epidemiology Biomarkers & Prevention vol. 13 , ( 5 ) 698 - 708 .

Rahman P, Jones A, Curtis J, Bartlett S, Peddle L, Fernandez BA, Freimer NB ( 2004 ) . The Newfoundland population: a unique resource for genetic investigation of complex diseases . Human Molecular Genetics vol. 13 , ( 12 ) 1287 - 1287 .

Mein CA, Caulfield MJ, Dobson RJ, Munroe PB ( 2004 ) . Genetics of essential hypertension . Human Molecular Genetics vol. 13 , ( REV. ISS. 1 )

Mein CA, Caulfield MJ, Dobson RJ, Munroe PB ( 2004 ) . Genetics of essential hypertension . Hum Mol Genet vol. 13 Spec No 1 , R169 - R175 .

Shohaimi S, Bingham S, Welch A, Luben R, Day N, Wareham N, Khaw K-T ( 2004 ) . Occupational social class, educational level and area deprivation independently predict plasma ascorbic acid concentration: a cross-sectional population based study in the Norfolk cohort of the European Prospective Investigation into Cancer (EPIC-Norfolk) . European Journal of Clinical Nutrition vol. 58 , ( 10 ) 1432 - 1435 .

Goodson NJ, Silman AJ, Pattison DJ, Lunt M, Bunn D, Luben R, Day N, Khaw K-T et al. ( 2004 ) . Traditional cardiovascular risk factors measured prior to the onset of inflammatory polyarthritis . Rheumatology vol. 43 , ( 6 ) 731 - 736 .

Mathews CA, Reus VI, Bejarano J, Escamilla MA, Fournier E, Herrera LD, Lowe TL, McInnes LA et al. ( 2004 ) . Genetic studies of neuropsychiatric disorders in Costa Rica: a model for the use of isolated populations . Psychiatric Genetics vol. 14 , ( 1 ) 13 - 23 .

Pawlikowska L, Groen A, Eppens EF, Kunne C, Ottenhoff R, Looije N, Knisely AS, Killeen NP et al. ( 2004 ) . A mouse genetic model for familial cholestasis caused by ATP8B1 mutations reveals perturbed bile salt homeostasis but no impairment in bile secretion . Human Molecular Genetics vol. 13 , ( 8 ) 881 - 892 .

Yuyun MF, Khaw K-T, Luben R, Welch A, Bingham S, Day NE, Wareham NJ ( 2004 ) . A Prospective Study of Microalbuminuria and Incident Coronary Heart Disease and Its Prognostic Significance in a British Population . American Journal of Epidemiology vol. 159 , ( 3 ) 284 - 293 .

Yuyun MF, Khaw K-T, Luben R, Welch A, Bingham S, Day NE, Wareham NJ ( 2004 ) . Microalbuminuria independently predicts all-cause and cardiovascular mortality in a British population: The European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) population study . International Journal of Epidemiology vol. 33 , ( 1 ) 189 - 198 .

Harding A-H, Day NE, Khaw K-T, Bingham SA, Luben RN, Welsh A, Wareham NJ ( 2004 ) . Habitual fish consumption and glycated haemoglobin: The EPIC-Norfolk Study . European Journal of Clinical Nutrition vol. 58 , ( 2 ) 277 - 284 .

Yuyun MF, Khaw K, Luben R, Welch A, Bingham S, Day NE, Wareham NJ ( 2004 ) . Microalbuminuria and stroke in a British population: the European Prospective Investigation into Cancer in Norfolk (EPIC‐Norfolk) population study . Journal of Internal Medicine vol. 255 , ( 2 ) 247 - 256 .

Harding A-H, Day NE, Khaw K-T, Bingham S, Luben R, Welsh A, Wareham NJ ( 2004 ) . Dietary Fat and the Risk of Clinical Type 2 Diabetes . American Journal of Epidemiology vol. 159 , ( 1 ) 73 - 82 .

Khaw K-T, Reeve J, Luben R, Bingham S, Welch A, Wareham N, Oakes S, Day N ( 2004 ) . Prediction of total and hip fracture risk in men and women by quantitative ultrasound of the calcaneus: EPIC-Norfolk prospective population study . The Lancet vol. 363 , ( 9404 ) 197 - 202 .

Wolkoff AW, Suchy FJ, Moseley RH, Meier PJ, Gollan JL, Freimer N, Fitz JG, Boyer JL et al. ( 1998 ) . Advances in hepatic transport: Molecular mechanisms, genetic disorders, and treatment. A summary of the 1998 AASLD single topic conference . Hepatology . vol. 28 , 1713 - 1719 .

Bull LN, Carlton VE, Stricker NL, Baharloo S, DeYoung JA, Freimer NB, Magid MS, Kahn E et al. ( 2003 ) . Genetic and morphological findings in progressive familial intrahepatic cholestasis (Byler disease [PFIC‐1] and Byler syndrome): Evidence for heterogeneity . Hepatology vol. 26 , ( 1 ) 155 - 164 .

Knisely AS, Freimer NB ( 2003 ) . Insight into bile duct differentiation takes (notched) wings . Hepatology vol. 27 , ( 1 ) 298 - 298 .

Surtees P, Wainwright N, Luben R, Khaw K-T, Day N ( 2003 ) . Sense of Coherence and Mortality in Men and Women in the EPIC-Norfolk United Kingdom Prospective Cohort Study . American Journal of Epidemiology vol. 158 , ( 12 ) 1202 - 1209 .

Surtees P, Wainwright N, Khaw K-T, Luben R, Brayne C, Day N ( 2003 ) . Inflammatory dispositions: a population-based study of the association between hostility and peripheral leukocyte counts . Personality and Individual Differences vol. 35 , ( 6 ) 1271 - 1284 .

Glatt CE, Tampilic M, Christie C, DeYoung J, Freimer NB ( 2003 ) . Re‐Screening serotonin receptors for genetic variants identifies population and molecular genetic complexity . American Journal of Medical Genetics Part B Neuropsychiatric Genetics vol. 124B , ( 1 ) 92 - 100 .

Surtees P, Wainwright N, Day N, Brayne C, Luben R, Khaw K-T ( 2003 ) . Adverse experience in childhood as a developmental risk factor for altered immune status in adulthood . International Journal of Behavioral Medicine vol. 10 , ( 3 ) 251 - 268 .

( 2003 ) . DEPARTMENT OF ERROR . The Lancet vol. 362 , ( 9388 )

Caulfield M, Munroe P, Pembroke J, Study. FTMBGOH ( 2003 ) . Genome-wide mapping of human loci for essential hypertension . ACC Current Journal Review vol. 12 , ( 5 ) 32 - 33 .

Jakes RW, Day NE, Khaw K-T, Luben R, Oakes S, Welch A, Bingham S, Wareham NJ ( 2003 ) . Television viewing and low participation in vigorous recreation are independently associated with obesity and markers of cardiovascular disease risk: EPIC-Norfolk population-based study . European Journal of Clinical Nutrition vol. 57 , ( 9 ) 1089 - 1096 .

Hong KS, McInnes LA, Service SK, Song T, Lucas J, Silva S, Fournier E, León P et al. ( 2003 ) . Genetic mapping using haplotype and model‐free linkage analysis supports previous evidence for a locus predisposing to severe bipolar disorder at 5q31‐33 . American Journal of Medical Genetics Part B Neuropsychiatric Genetics vol. 125B , ( 1 ) 83 - 86 .

Rahman P, Jones A, Curtis J, Bartlett S, Peddle L, Fernandez BA, Freimer NB ( 2003 ) . The Newfoundland population: a unique resource for genetic investigation of complex diseases† . Human Molecular Genetics vol. 12 , ( suppl_2 ) r167 - r172 .

Newhouse SJ, Garcia E, Caulfield M, Munroe P ( 2003 ) . Haplotype structure of the WNK1 gene and association studies in hypertensive populations . BRITISH JOURNAL OF CLINICAL PHARMACOLOGY . vol. 56 , 245 - 245 .

Smith MR, Kinmonth A-L, Luben RN, Bingham S, Day NE, Wareham NJ, Welch A, Khaw K-T ( 2003 ) . Smoking status and differential white cell count in men and women in the EPIC-Norfolk population . Atherosclerosis vol. 169 , ( 2 ) 331 - 337 .

Bingham SA, Luben R, Welch A, Wareham N, Khaw K-T, Day N ( 2003 ) . Are imprecise methods obscuring a relation between fat and breast cancer? . The Lancet vol. 362 , ( 9379 ) 212 - 214 .

Munroe PB, Editorial Board ( 2003 ) . Hypercholesterolaemia and vascular function: is the p22phox gene the missing link? . Clin Sci (Lond) vol. 105 , ( 1 ) 11 - 12 .

Caulfield M, Munroe P, Pembroke J, Samani N, Dominiczak A, Brown M, Benjamin N, Webster J et al. ( 2003 ) . Genome-wide mapping of human loci for essential hypertension . Lancet vol. 361 , ( 9375 ) 2118 - 2123 .

Segurado R, Detera-Wadleigh SD, Levinson DF, Lewis CM, Gill M, Nurnberger JI, Craddock N, DePaulo JR et al. ( 2003 ) . Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part III: Bipolar Disorder . American Journal of Human Genetics vol. 73 , ( 1 ) 49 - 62 .

Sabatti C, Service S, Freimer N ( 2003 ) . False Discovery Rate in Linkage and Association Genome Screens for Complex Disorders . Genetics vol. 164 , ( 2 ) 829 - 833 .

Dunning AM, Ellis PD, McBride S, Kirschenlohr HL, Healey CS, Kemp PR, Luben RN, Chang-Claude J et al. ( 2003 ) . A transforming growth factorbeta1 signal peptide variant increases secretion in vitro and is associated with increased incidence of invasive breast cancer . Cancer Research vol. 63 , ( 10 ) 2610 - 2615 .

Bingham SA, Day NE, Luben R, Ferrari P, Slimani N, Norat T, Clavel-Chapelon F, Kesse E et al. ( 2003 ) . Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study . The Lancet vol. 361 , ( 9368 ) 1496 - 1501 .

Freimer N, Sabatti C ( 2003 ) . The Human Phenome Project . Nature Genetics vol. 34 , ( 1 ) 15 - 21 .

Service SK, Sandkuijl LA, Freimer NB ( 2003 ) . Cost-Effective Designs for Linkage Disequilibrium Mapping of Complex Traits . American Journal of Human Genetics vol. 72 , ( 5 ) 1213 - 1220 .

Surtees P, Wainwright N, Day N, Luben R, Brayne C, Khaw K-T ( 2003 ) . Association of depression with peripheral leukocyte counts in EPIC-Norfolk—role of sex and cigarette smoking . Journal of Psychosomatic Research vol. 54 , ( 4 ) 303 - 306 .

Shohaimi S, Luben R, Wareham N, Day N, Bingham S, Welch A, Oakes S, Khaw K-T ( 2003 ) . Residential area deprivation predicts smoking habit independently of individual educational level and occupational social class. A cross sectional study in the Norfolk cohort of the European Investigation into Cancer (EPIC-Norfolk) . Journal of Epidemiology & Community Health vol. 57 , ( 4 )

Knight J, Munroe PB, Pembroke JC, Caulfield MJ ( 2003 ) . Human chromosome 17 in essential hypertension . Ann Hum Genet vol. 67 , ( Pt 2 ) 193 - 206 .

Carvajal-Carmona LG, Ophoff R, Service S, Hartiala J, Molina J, Leon P, Ospina J, Bedoya G et al. ( 2003 ) . Genetic demography of Antioquia (Colombia) and the Central Valley of Costa Rica . Human Genetics vol. 112 , ( 5-6 ) 534 - 541 .

Garcia EA, Newhouse S, Caulfield MJ, Munroe PB ( 2003 ) . Genes and hypertension . Curr Pharm Des vol. 9 , ( 21 ) 1679 - 1689 .

Garcia EA, Aristizabal D, McEwen J, Mendez J, Munroe P, Caulfield M ( 2002 ) . Guanine nucleotide binding 3 (GNB3) haplotype analysis in the Venecia-Colombia Latin-American blood pressure study . AMERICAN JOURNAL OF HUMAN GENETICS . vol. 71 , 366 - 366 .

Harding A-H, Sargeant L, Khaw K-T, Welch A, Oakes S, Luben R, Bingham S, Day N et al. ( 2002 ) . Cross-sectional association between total level and type of alcohol consumption and glycosylated haemoglobin level: the EPIC-Norfolk Study . European Journal of Clinical Nutrition vol. 56 , ( 9 ) 882 - 890 .

Escamilla MA, Batki S, Reus VI, Spesny M, Molina J, Service S, Vinogradov S, Neylan T et al. ( 2002 ) . Comorbidity of bipolar disorder and substance abuse in Costa Rica: pedigree- and population-based studies . Journal of Affective Disorders vol. 71 , ( 1-3 ) 71 - 83 .

Merikangas KR, Chakravarti A, Moldin SO, Araj H, Blangero J, Burmeister M, Crabbe JC, Depaulo JR et al. ( 2002 ) . Future of genetics of mood disorders research . Biological Psychiatry vol. 52 , ( 6 ) 457 - 477 .

Sandhu MS, Luben R, Day NE, Khaw K-T ( 2002 ) . Self-reported birth weight and subsequent risk of colorectal cancer . Cancer Epidemiology Biomarkers & Prevention vol. 11 , ( 9 ) 935 - 938 .

Ophoff RA, Escamilla MA, Service SK, Spesny M, Meshi DB, Poon W, Molina J, Fournier E et al. ( 2002 ) . Genomewide Linkage Disequilibrium Mapping of Severe Bipolar Disorder in a Population Isolate . American Journal of Human Genetics vol. 71 , ( 3 ) 565 - 574 .

Jakes RW, Day NE, Patel B, Khaw K-T, Oakes S, Luben R, Welch A, Bingham S et al. ( 2002 ) . Physical Inactivity Is Associated with Lower Forced Expiratory Volume in 1 Second . American Journal of Epidemiology vol. 156 , ( 2 ) 139 - 147 .

Glatt CE, Freimer NB ( 2002 ) . Association analysis of candidate genes for neuropsychiatric disease: the perpetual campaign . Trends in Genetics vol. 18 , ( 6 ) 307 - 312 .

Caulfield M, Pembroke J, Dominiczak A, Samani N, Brown M, Clayton D, Ratcliffe P, Lathrop M et al. ( 2002 ) . The MRC British Genetics of Hypertension Study - Genome-wide screen results . JOURNAL OF HYPERTENSION . vol. 20 , S7 - S7 .

Mulligan AA, Luben RN, Welch AA, Bingham SA ( 2002 ) . Daidzein and genistein intakes in England (the EPIC Norfolk cohort) . IARC Scientific Publications vol. 156 , 369 - 370 .

Bingham SA, Luben R, Day NE, Riboli E ( 2002 ) . Plant polysaccharides, meat and colorectal cancer . IARC Scientific Publications vol. 156 , 349 - 352 .

Luben R, Khaw KT, Welch A, Bingham S, Wareham N, Oakes S, Day NE ( 2002 ) . Plasma vitamin C, cancer mortality and incidence in men and women: a prospective study . IARC Scientific Publications vol. 156 , 117 - 118 .

Titan SMO, Bingham S, Welch A, Luben R, Oakes S, Day N, Khaw K-T ( 2001 ) . Frequency of eating and concentrations of serum cholesterol in the Norfolk population of the European prospective investigation into cancer (EPIC-Norfolk): cross sectional study . The BMJ vol. 323 , ( 7324 )

Harding A-H, Sargeant LA, Welch A, Oakes S, Luben RN, Bingham S, Day NE, Khaw K-T et al. ( 2001 ) . Fat Consumption and HbA1c Levels The EPIC-Norfolk Study . Diabetes Care vol. 24 , ( 11 ) 1911 - 1916 .

Basham VM, Pharoah PD, Healey CS, Luben RN, Day NE, Easton DF, Ponder BA, Dunning AM ( 2001 ) . Polymorphisms in CYP1A1 and smoking: no association with breast cancer risk . Carcinogenesis vol. 22 , ( 11 ) 1797 - 1800 .

Sandhu MS, Luben R, Khaw KT ( 2001 ) . Self reported non-insulin dependent diabetes, family history, and risk of prevalent colorectal cancer: population based, cross sectional study . Journal of Epidemiology & Community Health vol. 55 , ( 11 )

McInnes LA, Service SK, Reus VI, Barnes G, Charlat O, Jawahar S, Lewitzky S, Yang Q et al. ( 2001 ) . Fine-scale mapping of a locus for severe bipolar mood disorder on chromosome 18p11.3 in the Costa Rican population . Proceedings of the National Academy of Sciences of the United States of America vol. 98 , ( 20 ) 11485 - 11490 .

Metherell LA, Akker SA, Munroe PB, Rose SJ, Caulfield M, Savage MO, Chew SL, Clark AJ ( 2001 ) . Pseudoexon activation as a novel mechanism for disease resulting in atypical growth-hormone insensitivity . Am J Hum Genet vol. 69 , ( 3 ) 641 - 646 .

Faham M, Baharloo S, Tomitaka S, DeYoung J, Freimer NB ( 2001 ) . Mismatch repair detection (MRD): high-throughput scanning for DNA variations . Human Molecular Genetics vol. 10 , ( 16 ) 1657 - 1664 .

McKeown NM, Day NE, Welch AA, Runswick SA, Luben RN, Mulligan AA, McTaggart A, Bingham SA ( 2001 ) . Use of biological markers to validate self-reported dietary intake in a random sample of the European Prospective Investigation into Cancer United Kingdom Norfolk cohort 1 , 2 , 3 . American Journal of Clinical Nutrition vol. 74 , ( 2 ) 188 - 196 .

Ophoff RA, DeYoung J, Service SK, Joosse M, Caffo NA, Sandkuijl LA, Terwindt GM, Haan J et al. ( 2001 ) . Hereditary Vascular Retinopathy, Cerebroretinal Vasculopathy, and Hereditary Endotheliopathy with Retinopathy, Nephropathy, and Stroke Map to a Single Locus on Chromosome 3p21.1-p21.3 . American Journal of Human Genetics vol. 69 , ( 2 ) 447 - 453 .

Sargeant L, Khaw K, Bingham S, Day N, Luben R, Oakes S, Welch A, Wareham N ( 2001 ) . Fruit and vegetable intake and population glycosylated haemoglobin levels: the EPIC-Norfolk Study . European Journal of Clinical Nutrition vol. 55 , ( 5 ) 342 - 348 .

Sargeant LA, Khaw KT, Bingham S, Day NE, Luben RN, Oakes S, Welch A, Wareham NJ ( 2001 ) . Cigarette smoking and glycaemia: the EPIC-Norfolk Study . International Journal of Epidemiology vol. 30 , ( 3 ) 547 - 554 .

Sala E, Warren R, McCann J, Duffy S, Luben R, Day N ( 2001 ) . Mammographic parenchymal patterns and breast cancer natural history--a case-control study . Acta Oncologica vol. 40 , ( 4 ) 461 - 465 .

Sandhu MS, Luben R, Khaw K-T ( 2001 ) . Prevalence and family history of colorectal cancer: implications for screening . Journal of Medical Screening vol. 8 , ( 2 ) 69 - 72 .

Leung KY, Greene ND, Munroe PB, Mole SE ( 2001 ) . Identification of a transactivation motif in the CLN3 protein . IUBMB Life vol. 51 , ( 5 ) 295 - 298 .

MATHEWS CA, AMIGHETTI LDH, LOWE TL, VAN DE WETERING BJM, FREIMER NB, REUS VI ( 2001 ) . Cultural Influences on Diagnosis and Perception of Tourette Syndrome in Costa Rica . Journal of the American Academy of Child & Adolescent Psychiatry vol. 40 , ( 4 ) 456 - 463 .

Glatt CE, DeYoung JA, Delgado S, Service SK, Giacomini KM, Edwards RH, Risch N, Freimer NB ( 2001 ) . Screening a large reference sample to identify very low frequency sequence variants: comparisons between two genes . Nature Genetics vol. 27 , ( 4 ) 435 - 438 .

Couto E, Harrison D, Duffy S, Myles J, Sala E, Warren R, Day N, Luben R et al. ( 2001 ) . Estimation of disease progression parameters from case-control data: application to mammographic patterns and breast cancer natural history . Journal of Cancer Epidemiology and Prevention vol. 6 , ( 2 ) 235 - 242 .

Khaw K-T, Bingham S, Welch A, Luben R, Wareham N, Oakes S, Day N ( 2001 ) . Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study . The Lancet vol. 357 , ( 9257 ) 657 - 663 .

Service SK, Ophoff RA, Freimer NB ( 2001 ) . The genome-wide distribution of background linkage disequilibrium in a population isolate . Human Molecular Genetics vol. 10 , ( 5 ) 545 - 551 .

Garner C, McInnes LA, Service SK, Spesny M, Fournier E, Leon P, Freimer NB ( 2001 ) . Linkage Analysis of a Complex Pedigree with Severe Bipolar Disorder, Using a Markov Chain Monte Carlo Method . American Journal of Human Genetics vol. 68 , ( 4 ) 1061 - 1064 .

Jakes RW, Khaw K-T, Day NE, Bingham S, Welch A, Oakes S, Luben R, Dalzell N et al. ( 2001 ) . Patterns of physical activity and ultrasound attenuation by heel bone among Norfolk cohort of European Prospective Investigation of Cancer (EPIC Norfolk): population based study . The BMJ vol. 322 , ( 7279 )

Khaw K-T, Wareham N, Luben R, Bingham S, Oakes S, Welch A, Day N ( 2001 ) . Glycated haemoglobin, diabetes, and mortality in men in Norfolk cohort of European Prospective Investigation of Cancer and Nutrition (EPIC-Norfolk) . The BMJ vol. 322 , ( 7277 )

Leung KY, Greene ND, Munroe PB, Mole SE ( 2001 ) . Analysis of CLN3-protein interactions using the yeast two-hybrid system . Eur J Paediatr Neurol vol. 5 Suppl A , 89 - 93 .

Escamilla MA, McInnes LA, Service SK, Spesny M, Reus VI, Molina J, Gallegos A, Fournier E et al. ( 2001 ) . Genome screening for linkage disequilibrium in a Costa Rican sample of patients with bipolar‐I disorder: A follow‐up study on chromosome 18 . American Journal of Medical Genetics vol. 105 , ( 2 ) 207 - 213 .

Alsanea O, Wada N, Ain K, Wong M, Taylor K, Ituarte PHG, Treseler PA, Weier H-U et al. ( 2000 ) . Is familial non-medullary thyroid carcinoma more aggressive than sporadic thyroid cancer? A multicenter series . Surgery vol. 128 , ( 6 ) 1043 - 1051 .

Dunning AM, Durocher F, Healey CS, Teare MD, McBride SE, Carlomagno F, Xu C-F, Dawson E et al. ( 2000 ) . The Extent of Linkage Disequilibrium in Four Populations with Distinct Demographic Histories . American Journal of Human Genetics vol. 67 , ( 6 ) 1544 - 1554 .

Healey CS, Dunning AM, Dawn Teare M, Chase D, Parker L, Burn J, Chang-Claude J, Mannermaa A et al. ( 2000 ) . A common variant in BRCA2 is associated with both breast cancer risk and prenatal viability . Nature Genetics vol. 26 , ( 3 ) 362 - 364 .

Ospina-Duque J, Duque C, Carvajal-Carmona L, Ortiz-Barrientos D, Soto I, Pineda N, Cuartas M, Calle J et al. ( 2000 ) . An association study of bipolar mood disorder (type I) with the 5-HTTLPR serotonin transporter polymorphism in a human population isolate from Colombia . Neuroscience Letters vol. 292 , ( 3 ) 199 - 202 .

Bull LN, Roche E, Song EJ, Pedersen J, Knisely AS, van der Hagen CB, Eiklid K, Aagenaes Ø et al. ( 2000 ) . Mapping of the Locus for Cholestasis-Lymphedema Syndrome (Aagenaes Syndrome) to a 6.6-cM Interval on Chromosome 15q . American Journal of Human Genetics vol. 67 , ( 4 ) 994 - 999 .

Ospina-Duque J, Carvajal-Carmona L, Calle J, López C, Ochoa L, García J, Cuartas M, Ortiz-Barrientos D et al. ( 2000 ) . A search for genetic loci involved in predisposition to bipolar mood disorder in the population of Antioquia, Colombia . American Journal of Medical Genetics - Neuropsychiatric Genetics vol. 96 , ( 4 )

Ospina-Duque J, Duque C, Carvajal-Carmona L, Cuartas M, Ortiz-Barrientos D, Soto I, Pineda N, Calle J et al. ( 2000 ) . Lack of association between a serotonin transporter promoter polymorphism and BP1 in Antioquia, Colombia . American Journal of Medical Genetics - Neuropsychiatric Genetics vol. 96 , ( 4 ) 490 - 491 .

Sala E, Warren R, McCann J, Duffy S, Luben R, Day N ( 2000 ) . High-risk mammographic parenchymal patterns, hormone replacement therapy and other risk factors: a case-control study . International Journal of Epidemiology vol. 29 , ( 4 ) 629 - 636 .

Baharloo S, Service SK, Risch N, Gitschier J, Freimer NB ( 2000 ) . Familial Aggregation of Absolute Pitch . American Journal of Human Genetics vol. 67 , ( 3 ) 755 - 758 .

Sala E, Warren R, Duffy S, Welch A, Luben R, Day N ( 2000 ) . High risk mammographic parenchymal patterns and diet: a case–control study . British Journal of Cancer vol. 83 , ( 1 ) 121 - 126 .

Munroe PB, Caulfield MJ ( 2000 ) . Genetics of hypertension . Current Opinion in Genetics & Development vol. 10 , ( 3 ) 325 - 329 .

Sargeant LA, Wareham NJ, Bingham S, Day NE, Luben RN, Oakes S, Welch A, Khaw KT ( 2000 ) . Vitamin C and hyperglycemia in the European Prospective Investigation into Cancer--Norfolk (EPIC-Norfolk) study: a population-based study . Diabetes Care vol. 23 , ( 6 ) 726 - 732 .

Munroe PB, Knight J, Caulfield MJ ( 2000 ) . 1990-2000: progress in determining high blood pressure genes . Annals, Academy of Medicine, Singapore vol. 29 , ( 3 ) 357 - 363 .

Escamilla MA, DeMille MC, Benavides E, Roche E, Almasy L, Pittman S, Hauser J, Lew DF et al. ( 2000 ) . A Minimalist Approach to Gene Mapping: Locating the Gene for Acheiropodia, by Homozygosity Analysis . American Journal of Human Genetics vol. 66 , ( 6 ) 1995 - 2000 .

Healey CS, Dunning AM, Durocher F, Teare D, Pharoah PDP, Luben RN, Easton DF, Ponder BAJ ( 2000 ) . Polymorphisms in the human aromatase cytochrome P450 gene (CYP19) and breast cancer risk . Carcinogenesis vol. 21 , ( 2 ) 189 - 193 .

Sala E, Warren R, McCann J, Duffy S, Luben R, Day N ( 2000 ) . Smoking and high-risk mammographic parenchymal patterns: a case-control study . Breast Cancer Research vol. 2 , ( 1 )

Caulfield M, Papp J, Pembroke J, Munroe P, Farrall M, Dominiczak A, Clayton D, Ratcliffe P et al. ( 2000 ) . A new tool for checks of data precision within the MRC British genetics of hypertension study . J HYPERTENS . vol. 18 , S180 - S180 .

Munroe P, Sandhu M, Jadhav D, Knight J, Clark A, Caulfield M ( 2000 ) . No association of the epithelial sodium channel beta-subunit T594M variant with essential hypertension in an African Caribbean population . J HYPERTENS vol. 18 , S178 - S178 .

Sala E, Solomon L, Warren R, McCann J, Duffy S, Luben R, Day N ( 2000 ) . Size, node status and grade of breast tumours: association with mammographic parenchymal patterns . European Radiology vol. 10 , ( 1 ) 157 - 161 .

Fraser GE, Welch A, Luben R, Bingham SA, Day NE ( 2000 ) . The Effect of Age, Sex, and Education on Food Consumption of a Middle-Aged English Cohort—EPIC in East Anglia . Preventive Medicine vol. 30 , ( 1 ) 26 - 34 .

Janes RW, Munroe PB, Mitchison HM, Gardiner RM, Mole SE, Wallace BA ( 1999 ) . A model for Batten disease protein CLN3: Functional implications from homology and mutations . FEBS Letters vol. 399 , ( 1-2 ) 75 - 77 .

Sala E, Warren R, McCann J, Duffy S, Luben R, Day N ( 1999 ) . High-risk mammographic parenchymal patterns and anthropometric measures: A case–control study . British Journal of Cancer vol. 81 , ( 7 ) 1257 - 1261 .

Dunning AM, McBride S, Gregory J, Durocher F, Foster NA, Healey CS, Smith N, Pharoah PDP et al. ( 1999 ) . No association between androgen or vitamin D receptor gene polymorphisms and risk of breast cancer . Carcinogenesis vol. 20 , ( 11 ) 2131 - 2135 .

Mole SE, Mitchison HM, Munroe PB ( 1999 ) . Molecular basis of the neuronal ceroid lipofuscinoses: Mutations in CLN1, CLN2, CLN3, and CLN5 . Human Mutation vol. 14 , ( 3 ) 199 - 215 .

Bull LN, Pabón-Peña CR, Freimer NB ( 1999 ) . Compound Microsatellite Repeats: Practical and Theoretical Features . Genome Research vol. 9 , ( 9 ) 830 - 838 .

Day N, Oakes S, Luben R, Khaw KT, Bingham S, Welch A, Wareham N ( 1999 ) . EPIC-Norfolk: study design and characteristics of the cohort. European Prospective Investigation of Cancer . British Journal of Cancer . vol. 80 Suppl 1 , 95 - 103 .

( 1999 ) . Erratum: Hum Genet (1999) 104 : 241–248 . Human Genetics vol. 104 , ( 6 ) 528 - 528 .

Escamilla MA, McInnes LA, Spesny M, Reus VI, Service SK, Shimayoshi N, Tyler DJ, Silva S et al. ( 1999 ) . Assessing the Feasibility of Linkage Disequilibrium Methods for Mapping Complex Traits: An Initial Screen for Bipolar Disorder Loci on Chromosome 18 . American Journal of Human Genetics vol. 64 , ( 6 ) 1670 - 1678 .

Service SK, Lang DWT, Freimer NB, Sandkuijl LA ( 1999 ) . Linkage-Disequilibrium Mapping of Disease Genes by Reconstruction of Ancestral Haplotypes in Founder Populations . American Journal of Human Genetics vol. 64 , ( 6 ) 1728 - 1738 .

Bull LN, Juijn JA, Liao M, van Eijk MJT, Sinke RJ, Stricker NL, DeYoung JA, Carlton VEH et al. ( 1999 ) . Fine-resolution mapping by haplotype evaluation: the examples of PFIC1 and BRIC . Human Genetics vol. 104 , ( 3 ) 241 - 248 .

Stephenson JBP, Greene NDE, Leung KY, Munroe PB, Mole SE, Gardiner RM, Taschner PEM, O'Regan M et al. ( 1999 ) . The Molecular Basis of GROD-Storing Neuronal Ceroid Lipofuscinoses in Scotland . Molecular Genetics and Metabolism . vol. 66 , 245 - 247 .

Lauronen L, Munroe PB, Järvelä I, Autti T, Mitchison HM, O’Rawe AM, Gardiner RM, Mole SE et al. ( 1999 ) . Delayed classic and protracted phenotypes of compound heterozygous juvenile neuronal ceroid lipofuscinosis . Neurology vol. 52 , ( 2 ) 360 - 365 .

Munroe PB, Olgunturk RO, Fryns J-P, Maldergem LV, Ziereisen F, Yuksel B, Gardiner RM, Chung E ( 1999 ) . Mutations in the gene encoding the human matrix Gla protein cause Keutel syndrome . Nature Genetics vol. 21 , ( 1 ) 142 - 144 .

Freimer NB, Reus VI, Escamilla M, Spesny M, Smith L, Service S, Gallegos A, Meza L et al. ( 1998 ) . An approach to investigating linkage for bipolar disorder using large Costa Rican pedigrees . American Journal of Medical Genetics vol. 67 , ( 3 ) 254 - 263 .

Knowles JA, Fyer AJ, Vieland VJ, Weissman MM, Hodge SE, Heiman GA, Haghighi F, de Jesus GM et al. ( 1998 ) . Results of a genome‐wide genetic screen for panic disorder . American Journal of Medical Genetics vol. 81 , ( 2 ) 139 - 147 .

Escamilla MA, Spesny M, Reus VI, Gallegos A, Meza L, Molina J, Sandkuijl LA, Fournier E et al. ( 1998 ) . Use of linkage disequilibrium approaches to map genes for bipolar disorder in the Costa Rican population . American Journal of Medical Genetics vol. 67 , ( 3 ) 244 - 253 .

Sala E, Warren R, McCann J, Duffy S, Day N, Luben R ( 1998 ) . Mammographic parenchymal patterns and mode of detection: implications for the breast screening programme . Journal of Medical Screening vol. 5 , ( 4 ) 207 - 212 .

Strautnieks SS, Bull LN, Knisely AS, Kocoshis SA, Dahl N, Arnell H, Sokal E, Dahan K et al. ( 1998 ) . A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis . Nature Genetics vol. 20 , ( 3 ) 233 - 238 .

Munroe PB, Greene ND, Leung KY, Mole SE, Gardiner RM, Mitchison HM, Stephenson JB, Crow YJ ( 1998 ) . Sharing of PPT mutations between distinct clinical forms of neuronal ceroid lipofuscinoses in patients from Scotland . Journal of Medical Genetics vol. 35 , ( 9 )

Munroe PB, Strautnieks SS, Farrall M, Daniel HI, Lawson M, DeFreitas P, Fogarty P, Gardiner RM et al. ( 1998 ) . Absence of Linkage of the Epithelial Sodium Channel to Hypertension in Black Caribbeans* . American Journal of Hypertension vol. 11 , ( 8 ) 942 - 945 .

McInnes LA, Reus VI, Freimer NB ( 1998 ) . Mapping genes for psychiatric disorders and behavioral traits . Current Opinion in Genetics & Development vol. 8 , ( 3 ) 287 - 292 .

Bull LN, van Eijk MJT, Pawlikowska L, DeYoung JA, Juijn JA, Liao M, Klomp LWJ, Lomri N et al. ( 1998 ) . A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis . Nature Genetics vol. 18 , ( 3 ) 219 - 224 .

Baharloo S, Johnston PA, Service SK, Gitschier J, Freimer NB ( 1998 ) . Absolute Pitch: An Approach for Identification of Genetic and Nongenetic Components . American Journal of Human Genetics vol. 62 , ( 2 ) 224 - 231 .

Mitchison HM, Hofmann SL, Becerra CHR, Munroe PB, Lake BD, Crow YJ, Stephenson JBP, Williams RE et al. ( 1998 ) . Mutations in the Palmitoyl-Protein Thioesterase Gene (PPT; CLN1) Causing Juvenile Neuronal Ceroid Lipofuscinosis with Granular Osmiophilic Deposits . Human Molecular Genetics vol. 7 , ( 2 ) 291 - 297 .

Mitchison HM, Hofmann SL, Becerra CHR, Munroe PB, Lake BD, Crow YJ, Stephenson JBP, Williams RE et al. ( 1998 ) . Corrigendum: Mutations in the palmitoyl-protein thioesterase gene (PPT; CLN1) causing juvenile neuronal ceroid lipofuscinosis with granular osmiophilic deposits (Human Molecular Genetics (1998) 7 (291-297)) . Human Molecular Genetics vol. 7 , ( 4 )

Bull LN, Freimer NB, Balistreri WF, O'Connell N, Setchell KDR, Kocoshis SA, Putnam PE, Agostini RM et al. ( 1997 ) . A non-Amish infant with true Byler disease . Pediatric Pathology and Laboratory Medicine vol. 17 , ( 3 ) 522 - 523 .

Freimer NB, Service SK, Slatkin M ( 1997 ) . Expanding on population studies . Nature Genetics vol. 17 , ( 4 ) 371 - 373 .

Strautnieks SS, Kagalwalla AF, Tanner MS, Knisely AS, Bull L, Freimer N, Kocoshis SA, Gardiner RM et al. ( 1997 ) . Identification of a Locus for Progressive Familial Intrahepatic Cholestasis PFIC2on Chromosome 2q24 . American Journal of Human Genetics vol. 61 , ( 3 ) 630 - 633 .

Sinke RJ, Carlton VEH, Juijn JA, Delhaas T, Bull L, Henegouwen GPB, van Hattum J, Keller KM et al. ( 1997 ) . Benign recurrent intrahepatic cholestasis (BRIC): evidence of genetic heterogeneity and delimitation of the BRIC locus to a 7-cM interval between D18S69 and D18S64 . Human Genetics vol. 100 , ( 3-4 ) 382 - 387 .

Munroe PB, Mitchison HM, O'Rawe AM, Anderson JW, Boustany R-M, Lerner TJ, Taschner PEM, de Vos N et al. ( 1997 ) . Spectrum of Mutations in the Batten Disease Gene, CLN3 . American Journal of Human Genetics vol. 61 , ( 2 ) 310 - 316 .

Reus VI, Freimer NB ( 1997 ) . Understanding the Genetic Basis of Mood Disorders: Where Do We Stand? . American Journal of Human Genetics vol. 60 , ( 6 ) 1283 - 1288 .

Munroe PB, Strautnieks SS, Farrall M, Daniel HI, Kamdar S, Lawson M, DeFreitas P, Fogarty P et al. ( 1997 ) . Investigation of the epithelial sodium channel (hENaC) as a candidate gene for essential hypertension (EH) in African Caribbeans . American Journal of Hypertension vol. 10 , ( S2 ) 5a - 5a .

Mitchison HM, Munroe PB, O'Rawe AM, Taschner PEM, de Vos N, Kremmidiotis G, Lensink I, Munk AC et al. ( 1997 ) . Genomic Structure and Complete Nucleotide Sequence of the Batten Disease Gene,CLN3 . Genomics vol. 40 , ( 2 ) 346 - 350 .

Daniel H, Munroe P, Kamdar S, Lawson M, Lavender P, Forgaty P, Caulfield M ( 1997 ) . The atrial natriuretic peptide gene and essential hypertension in African-Caribbeans from St Vincent and the Grenadines . Journal of Human Hypertension vol. 11 , ( 2 ) 113 - 117 .

Sela-Herman S, Bull L, Lomri N, Rahmaoui C, Luther T, Hammerman P, Genant J, Freimer N et al. ( 1996 ) . In Search of a Gene for Hereditary Cholestasis . Molecular Genetics and Metabolism vol. 59 , ( 2 ) 98 - 103 .

Järvelä I, Mitchison HM, Munroe PB, O'Rawe AM, Mole SE, Syvänen AC ( 1996 ) . Rapid diagnostic test for the major mutation underlying Batten disease . Journal of Medical Genetics vol. 33 , ( 12 )

McInnes LA, Escamilla MA, Service SK, Reus VI, Leon P, Silva S, Rojas E, Spesny M et al. ( 1996 ) . A complete genome screen for genes predisposing to severe bipolar disorder in two Costa Rican pedigrees . Proceedings of the National Academy of Sciences of the United States of America vol. 93 , ( 23 ) 13060 - 13065 .

Scanlon TJ, Luben R, Lyle P ( 1996 ) . Comparing hypertension guidelines . The BMJ vol. 313 , ( 7066 )

Scanlon TJ, Luben R, Lyle P ( 1996 ) . Comparing hypertension guidelines. Guidelines are based on evidence from trials, not normal practice . BMJ vol. 313 , ( 7066 )

Knisely AS, Kocoshis S, O'Connell N, Setchell KD, Bull LN, Freimer NB ( 1996 ) . 36 DEFICIENCY OF CHENODEOXYCHOLIC ACID IN BILE: BYLER DISEASE AND BYLER SYNDROME . Journal of Pediatric Gastroenterology and Nutrition vol. 23 , ( 3 )

Crouau-Roy B, Service S, Slatkin M, Freimer N ( 1996 ) . A Fine-Scale Comparison of the Human and Chimpanzee Genomes: Linkage, Linkage Disequilibrium and Sequence Analysis . Human Molecular Genetics vol. 5 , ( 8 ) 1131 - 1137 .

Smith LB, Sapers B, Reus VI, Freimer NB ( 1996 ) . Attitudes towards bipolar disorder and predictive genetic testing among patients and providers . Journal of Medical Genetics vol. 33 , ( 7 )

Houwen RHJ, Sinke R, Juyn J, Freimer N, Berger R ( 1996 ) . 22 MAPPING OF THE GENE FOR BRIC AND BYLER DISEASE . Journal of Pediatric Gastroenterology and Nutrition vol. 22 , ( 4 )

Freimer NB, Reus VI, Escamilla MA, Mclnnes LA, Spesny M, Leon P, Service SK, Smith LB et al. ( 1996 ) . Genetic mapping using haplotype, association and linkage methods suggests a locus for severe bipolar disorder (BPI) at 18q22-q23 . Nature Genetics vol. 12 , ( 4 ) 436 - 441 .

Freimer NB, Blower S, Slatkin M ( 1996 ) . Pathogens & strain diversity: Is sex disruptive? . Nature Medicine vol. 2 , ( 4 ) 401 - 403 .

Munroe PB, Mitchison HM, Mole SE, Gardiner RM, Rapola J, Mustonen A, Järvelä I ( 1996 ) . Prenatal diagnosis of Batten's disease . The Lancet vol. 347 , ( 9007 ) 1014 - 1015 .

Garza JC, Freimer NB ( 1996 ) . Homoplasy for size at microsatellite loci in humans and chimpanzees . Genome Research vol. 6 , ( 3 ) 211 - 217 .

Di Rienzo A, Peterson AC, Freimer NB ( 1995 ) . Amplification with Arbitrary Primers . Methods in Molecular Biology vol. 54 , 123 - 129 .

JÄRVELÄ IE, MITCHISON HM, O'RAWE AM, MUNROE PB, TASCHNER PEM, DEVOS N, LERNER TJ, D'ARIGO KL et al. ( 1995 ) . YAC and Cosmid Contigs Spanning the Batten Disease (CLN3) Region at 16p12.1–p11.2 . Genomics vol. 29 , ( 2 ) 478 - 489 .

Munroe PB, Daniel HI, Farrall M, Lawson M, Bouloux PM, Caulfield MJ ( 1995 ) . Absence of genetic linkage between polymorphisms of the insulin receptor gene and essential hypertension . Journal of Human Hypertension . vol. 9 , 669 - 670 .

Garza JC, Slatkin M, Freimer NB ( 1995 ) . Microsatellite allele frequencies in humans and chimpanzees, with implications for constraints on allele size . Molecular Biology and Evolution vol. 12 , ( 4 ) 594 - 603 .

McInnes LA, Freimer NB ( 1995 ) . Mapping genes for psychiatric disorders and behavioral traits . Current Opinion in Genetics & Development vol. 5 , ( 3 ) 376 - 381 .

Carlton VEH, Knisely AS, Freimer NB ( 1995 ) . Mapping of a locus for progressive familial intrahepatic cholestasis (Byler disease) to 18q21-q22, the benign recurrent intrahepatic cholestasis region . Human Molecular Genetics vol. 4 , ( 6 ) 1049 - 1053 .

Peterson AC, Di Rienzo A, Lehesjokl A-E, de la Chapelle A, Slatkin M, Frelmer NB ( 1995 ) . The distribution of linkage disequilibrium over anonymous genome regions . Human Molecular Genetics vol. 4 , ( 5 ) 887 - 894 .

Houwen RHJ, Baharloo S, Blankenship K, Raeymaekers P, Juyn J, Sandkuijl LA, Freimer NB ( 1994 ) . Genome screening by searching for shared segments: mapping a gene for benign recurrent intrahepatic cholestasis . Nature Genetics vol. 8 , ( 4 ) 380 - 386 .

Dooley TP, Probst P, Munroe PB, Mole SE, Liu Z, Doggett NA ( 1994 ) . Genomic Organization and DNA Sequence of the Human Catecholamine-Sulfating Phenol Sulfotransferase Gene (STM) . Biochemical and Biophysical Research Communications vol. 205 , ( 2 ) 1325 - 1332 .

Dooley TP, Mitchison HM, Munroe PB, Probst P, Neal M, Siciliano MJ, Deng ZM, Doggett NA et al. ( 1994 ) . Mapping of Two Phenol Sulfotransferase Genes, STP and STM, to 16p: Candidate Genes for Batten Disease . Biochemical and Biophysical Research Communications vol. 205 , ( 1 ) 482 - 489 .

Kamdar S, Daniel H, Fogarty P, Lawson M, Munroe P, Caulfield M ( 1994 ) . ACE insertion/deletion (I/D) polymorphism in Vincentian African Caribbeans with essential hypertension . Journal of Human Hypertension . vol. 8 ,

Munroe PB, Johnston A, Duke VM, Daniel HI, Bouloux PM, Lawson M, Caulfield MJ ( 1994 ) . Investigation of lipoprotein lipase (LPL) as a candidate gene for dyslipidaemic hypertension . Journal of Human Hypertension . vol. 8 , 613 - 614 .

Daniel HI, Munroe PB, Lawson M, Fogarty P, Kamdar SM, Caulfield MJ ( 1994 ) . Investigation of the renin gene as a putative locus for essential hypertension (EH) in Vincentian African Caribbeans . Journal of Human Hypertension . vol. 8 , 609 - 610 .

Caulfield M, Lavender P, Farrall M, Munroe P, Lawson M, Turner P, Clark A ( 1994 ) . Linkage of the Angiotensinogen Gene to Essential Hypertension . New England Journal of Medicine vol. 330 , ( 23 ) 1629 - 1633 .

Di Rienzo A, Peterson AC, Garza JC, Valdes AM, Slatkin M, Freimer NB ( 1994 ) . Mutational processes of simple-sequence repeat loci in human populations . Proceedings of the National Academy of Sciences of the United States of America vol. 91 , ( 8 ) 3166 - 3170 .

Scanlon TJ, Luben RN, Scanlon FL, Singleton N ( 1993 ) . Is Friday the 13th bad for your health? . The BMJ vol. 307 , ( 6919 )

Di Rienzo A, Peterson A, Das S, Freimer NB ( 1993 ) . Genome mapping by arbitrary amplification of yeast artificial chromosomes . Mammalian Genome vol. 4 , ( 7 ) 359 - 363 .

Freimer NB, Sandkuijl LA, Blower SM ( 1993 ) . Incorrect specification of marker allele frequencies: effects on linkage analysis . American Journal of Human Genetics vol. 52 , ( 6 ) 1102 - 1110 .

Valdes AM, Slatkin M, Freimer NB ( 1993 ) . Allele frequencies at microsatellite loci: the stepwise mutation model revisited . Genetics vol. 133 , ( 3 ) 737 - 749 .

Munroe PB, Caulfield M, Daniel H, Lawson M, Bouloux PMG, Turner P ( 1993 ) . Analysis of the insulin receptor RsaI polymorphism in essential hypertension . British Journal of Clinical Pharmacology . vol. 35 ,

Bouloux PM, Munroe P, Kirk J, Besser GM ( 1992 ) . Sex and smell – an enigma resolved . Journal of Endocrinology vol. 133 , ( 3 ) 323 - 326 .

Consalez GG, Stayton CL, Freimer NB, Goonewardena P, Brown WT, Gilliam TC, Warren ST ( 1992 ) . Isolation and characterization of a highly polymorphic human locus (DXS455) in proximal Xq28 . Genomics vol. 12 , ( 4 ) 710 - 714 .

Bouloux P-MG, Hardelin J-P, Munroe P, Kirk JMW, Legouis R, Levilliers J, Hazan J, Weissenbach J et al. ( 1991 ) . A dinucleotide repeat polymorphism at the Kallmann locus (Xp22.3) . Nucleic Acids Research vol. 19 , ( 19 ) 5453 - 5453 .

Kleyn PW, Brzustowicz LM, Wilhelmsen KC, Freimer NB, Miller JM, Munsat TL, Gilliam TC ( 1991 ) . Spinal muscular atrophy is not the result of mutations at the beta-hexosaminidase or GM2-activator locus . Neurology vol. 41 , ( 9 ) 1418 - 1422 .

Gilliam TC, Freimer NB, Kaufmann CA, Powchik PP, Bassett AS, Bengtsson U, Wasmuth JJ ( 1989 ) . Deletion mapping of DNA markers to a region of chromosome 5 that cosegregates with schizophrenia . Genomics vol. 5 , ( 4 ) 940 - 944 .

Freimer N, Lu F, Chen J ( 1989 ) . Posttraumatic Stress and Conversion Disorders in a Laotian Refugee Veteran: Use of Amobarbital Interviews . The Journal of Nervous and Mental Disease vol. 177 , ( 7 ) 432 - 433 .