Publications:  Dr Stuart McDonald

Smith ALM, Whitehall JC, Bradshaw C, Gay D, Robertson F, Blain AP, Hudson G, Pyle A et al.(2020). Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis. Nature Cancer976-989.

Passman AM, Haughey MJ, Carlotti E, Williams M, Cereser B, Russo FP, Hoare M, Kocher H et al.(2020). 450 CLONAL DYNAMICS AND CELL-OF-ORIGIN OF NORMAL HEPATOCYTE EXPANSIONS IN HOMEOSTATIC HUMAN LIVERS AND THEIR ASSOCIATION WITH THE BILIARY EPITHELIUM. Gastroenterology vol. 158, (6) s-1276.

Passman AM, Haughey MJ, Carlotti E, Williams M, Cereser B, Russo FP, Hoare M, Kocher H et al. (2020). CLONAL DYNAMICS AND CELL-OF-ORIGIN OF NORMAL HEPATOCYTE EXPANSIONS IN HOMEOSTATIC HUMAN LIVERS AND THEIR ASSOCIATION WITH THE BILIARY EPITHELIUM. GASTROENTEROLOGY. vol. 158, S1276-S1276.

Martin S(2019). MLH1 deficiency leads to deregulated mitochondrial metabolism. Cell Death and Disease vol. 10, 795-795.

Passman A, Williams M, Carlotti E, Cereser B, Hoare M, Russo F, Kocher HM, Chin-Aleong J et al. (2019). The Cell of Origin of Normal Human Hepatocytes has a Common Ancestor with Biliary Epithelium and Hepatocyte Clonal Expansions Arise from the Portal Tract and Drift to the Central Vein. JOURNAL OF PATHOLOGY. vol. 249, S16-S16.

Baker AM, Cross W, Curtius K, Al Bakir I, Choi CHR, Davis HL, Temko D, Biswas S et al.(2019). Evolutionary history of human colitis-associated colorectal cancer. Gut vol. 68, (6) 985-995.

Zeki S, Hackett R, Dunn J, Bancil A, Preston S, Chin-Aleong J, Brown J, McDonald S (2019). PTU-105 Automated, algorithm based extraction of Barrett’s surveillance metrics from natural language text is reliable. Gut. vol. 68,

Baker A-M, Cereser B, Melton S, Fletcher AG, Rodriguez-Justo M, Tadrous PJ, Humphries A, Elia G et al.(2019). Quantification of Crypt and Stem Cell Evolution in the Normal and Neoplastic Human Colon. Cell Rep vol. 27, (8) 2524-2524.

Baker AM, Gabbutt C, Williams MJ, Cereser B, Jawad N, Rodriguez-Justo M, Jansen M, Barnes CP et al.(2019). Crypt fusion as a homeostatic mechanism in the human colon. Gut vol. 68, (11) 1986-1993.

Su T, Grady J, Afshar S, MCDONALD SAC, Taylor R, Douglass T, Greaves L(2018). Inherited pathogenic mitochondrial DNA mutations and gastrointestinal stem cell populations. Journal of Pathology vol. 246, (4) 427-432.

Cereser B, Jansen M, Austin E, Elia G, McFarlane T, van Deurzen CHM, Sieuwerts AM, Daidone MG et al.(2018). Analysis of clonal expansions through the normal and premalignant human breast epithelium reveals the presence of luminal stem cells. Journal of Pathology vol. 244, (1) 61-70.

Walther V, Davis H, Owusu CK, Sivaharan A, Williams M, Rodriguez-Justo M, Jansen M, Leedham S et al. (2017). CLONAL INTERACTIONS AS MECHANISMS OF POLYCLONALITY IN COLORECTAL ADENOMAS. GASTROENTEROLOGY. Conference: Digestive Disease Week vol. 152, S153-S153.

Baker A-M, Davis CHRCH, Al-Bakir I, Martinez P, Temko D, Cross W, Williams M, Biswas S et al. (2017). MULTI-REGION EXOME SEQUENCING REVEALS THE CLONAL EVOLUTION OF COLITIS-ASSOCIATED COLORECTAL CANCER. GASTROENTEROLOGY. Conference: Pathological Society vol. 152, S983-S984.

Woodland PJ, Grassi F, Peiris M, Aktar R, Ooi JL, Evans J, Lee C, McDonald SA et al. (2017). Sa1150 Innervation Pattern of the Distal Mucosal Squamous Epithelium May Underlie Hyposensitivity to Acid Reflux in Patients with Barrett’s Oesophagus. Gastroenterology. vol. 152,

Lavery DL, Baker AM, Van der Wel MJ, McDonald SAC, Quirke P, Novelli MR, Rodriguez-Justo M, Treanor D et al. (2017). Adaptive Clonal Heterogeneity During Oesophageal Cancer Progression. JOURNAL OF PATHOLOGY. Conference: Pathological Society vol. 243, S11-S11.

McDonald SA (2016). Somatic Evolution of Barrett's/Oesophageal Cancer. JOURNAL OF PATHOLOGY. vol. 240, 8-8.

Evans JA, McDonald SAC(2016). The complex, clonal, and controversial nature of barrett’s esophagus. Advances in Experimental Medicine and Biology vol. 908, 27-40.

Lavery DL, Martinez P, Gay LJ, Cereser B, Novelli MR, Rodriguez-Justo M, Meijer SL, Graham TA et al.(2016). Evolution of oesophageal adenocarcinoma from metaplastic columnar epithelium without goblet cells in Barrett's oesophagus. Gut vol. 65, (6) 907-913.

Alison M, Cereser B, Kocher H, McDonald SA (2015). Clonal analysis of the human liver reveals adaptable stem cell dynamics. HEPATOLOGY. vol. 62, 260A-260A.

Jansen M, McDonald SA, Lavery D, Wright NA, Martinez P, Graham TA, Gay LJ (2015). Spatial Sampling in Barrett's Oesophagus Shows Clonal Evolution of Oesophageal Adenocarcinoma from Metaplastic Non-Goblet Columnar Epithelium. JOURNAL OF PATHOLOGY. vol. 237, S21-S21.

Jawad N, Johnson C, Butterworth E, Saeed I, Feakins R, Rodriguez-Justo M, McDonald S, Wright N et al. (2015). OC-012 Do inflammatory polyps show features associated with the early stages of malignant progression?. Gut. vol. 64,

McDonald SAC, Lavery D, Wright NA, Jansen M(2015). Barrett oesophagus: lessons on its origins from the lesion itself. Nat Rev Gastroenterol Hepatol vol. 12, (1) 50-60.

Wong PP, Demircioglu F, Ghazaly E, Alrawashdeh W, Stratford MRL, Scudamore CL, Cereser B, Crnogorac-Jurcevic T et al.(2015). Dual-action combination therapy enhances angiogenesis while reducing tumor growth and spread. Cancer Cell vol. 27, (1) 123-137.

Wong P-P, Demircioglu F, Ghazaly E, Alrawashdeh W, Stratford M, Scudamore C, Cereser B, Crnogorac-Jurcevic T et al. (2015). NOVEL DUAL-ACTION COMBINATION THERAPY ENHANCES ANGIOGENESIS WHILST REDUCING TUMOR GROWTH AND SPREAD. JOURNAL OF VASCULAR RESEARCH. vol. 52, 6-6.

McDonald SAC, Lavery D, Wright NA, Jansen M(2015). Opinion : Barrett oesophagus: Lessons on its origins from the lesion itself. Nature Reviews Gastroenterology and Hepatology vol. 12, (1) 50-60.

McDonald SAC, Graham TA, Lavery DL, Wright NA, Jansen M(2015). The Barrett's Gland in Phenotype Space. Cellular and Molecular Gastroenterology and Hepatology vol. 1, (1) 41-54.

Lavery DL, Nicholson AM, Poulsom R, Jeffery R, Hussain A, Gay LJ, Jankowski JA, Zeki SS et al.(2014). The stem cell organisation, and the proliferative and gene expression profile of Barrett's epithelium, replicates pyloric-type gastric glands. Gut vol. 63, (12) 1854-1863.

Baker A-M, Cereser B, Melton S, Fletcher AG, Rodriguez-Justo M, Tadrous PJ, Humphries A, Elia G et al.(2014). Quantification of crypt and stem cell evolution in the normal and neoplastic human colon. Cell Rep vol. 8, (4) 940-947.

Pipinikas CP, Kiropoulos TS, Teixeira VH, Brown JM, Varanou A, Falzon M, Capitanio A, Bottoms SE et al.(2014). Cell migration leads to spatially distinct but clonally related airway cancer precursors. Thorax vol. 69, (6) 548-557.

Jawad N, Crook J, Baker AM, Cereser B, Rodriguez-Justo M, Graham T, Wright N, McDonald S (2014). PWE-086 Determining Stem Cell And Crypt Dynamics In Inflammatory Bowel Disease. Gut. vol. 63 Suppl 1, A161-A162.

Zeki SS, Haidry R, Justo-Rodriguez M, Lovat LB, Wright NA, McDonald SA(2014). Squamous cell carcinoma after radiofrequency ablation for Barrett's dysplasia. World J Gastroenterol vol. 20, (15) 4453-4456.

Jawad N, Graham TA, McDonald SAC, Wright NA(2014). Re: Mitochondria and tumor progression in ulcerative colitis. J Natl Cancer Inst vol. 106, (2)

Pipinikas CP, Kiropoulos TS, Teixeira VH, Brown JM, Varanou A, Falzon M, Capitanio A, Bottoms SE et al.(2014). Cell migration leads to spatially distinct but clonally related airway cancer precursors. Thorax vol. 69, (6) 548-557.

Teixeira V, Nadarajan P, Graham TA, Pipinikas CP, Brown JM, Falzon M, Nye E, Poulsom R et al. (2013). LINEAGE TRACING IN HUMANS REVEALS STOCHASTIC HOMEOSTASIS OF AIRWAY EPITHELIUM RESULTING FROM NEUTRAL COMPETITION OF BASAL CELL PROGENITORS. THORAX. vol. 68, A68-A68.

Teixera VH, Nadarajan P, Graham TA, Pipinikas CP, Brown TM, Falzon M, Nye E, Poulsom RP et al.(2013). Stochastic homeostasis in human airway epithelium is achieved by neutral competition of basal cell progenitors. eLife vol. 2, (22) e00966-e00966.

Zeki SS, Haidry R, Graham TA, Rodriguez-Justo M, Novelli M, Hoare J, Dunn J, Wright NA et al.(2013). Clonal selection and persistence in dysplastic Barrett's esophagus and intramucosal cancers after failed radiofrequency ablation. American Journal of Gastroenterology vol. 108, (10) 1584-1592.

Zeki SS, Haidry R, Graham TA, Rodriguez-Justo M, Novelli M, Hoare J, Dunn J, Wright NA et al.(2013). Clonal selection and persistence in dysplastic Barrett's esophagus and intramucosal cancers after failed radiofrequency ablation. Am J Gastroenterol vol. 108, (10) 1584-1592.

Gabriel JP, Komuta M, Roskams T, Wright NA, McDonald SA, Alison MR (2013). Comparison of the Histogenesis of Regenerative Nodules in Patients with Cirrhosis of Different Aetiologies. JOURNAL OF PATHOLOGY. vol. 231, 17-17.

Khan S, McDonald SAC, Wright NA, Graham TA, Odze RD, Rodriguez-Justo M, Zeki S(2013). Crypt dysplasia in Barrett's oesophagus shows clonal identity between crypt and surface cells. JOURNAL OF PATHOLOGY vol. 231, (1) 98-104.

Gabriel J, Graham TA, Kocher H, Wright NA, Alison M, McDonald SAC (2013). Methylation Patterns of Clonally-Related Hepatocytes Provide Evidence of a Periportal Stem Cell Niche in the Normal Human Liver. JOURNAL OF PATHOLOGY. vol. 231, 15-15.

Humphries A, Cereser B, Gay LJ, Miller DSJ, Das B, Gutteridge A, Elia G, Nye E et al.(2013). Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution. Proc Natl Acad Sci U S A vol. 110, (27) E2490-E2499.

Lavery D, Nicholson A, Jeffery R, Poulsom R, Barr H, Jankowski J, Novelli M, Shepherd N et al. (2013). BARRETT'S EPITHELIUM SHOWS EVIDENCE OF GASTRIC AND INTESTINAL DIFFERENTIATION PROGRAMMES BUT PRESERVES THE PROLIFERATIVE AND STEM CELL ARCHITECTURE OF GASTRIC GLANDS. GUT. vol. 62, A13-A13.

Khan S, McDonald S, Wright NA, Robert OD, Rodriguez-Justo M, Graham TA, Zeki S (2013). CRYPT CELL DYSPLASIA WITH MATURATION IN BARRETT'S ESOPHAGUS SHOWS CLONAL IDENTITY BETWEEN THE CRYPT AND SURFACE CELLS. GUT. vol. 62, A198-A199.

Cereser B, Baker A-MC, Tadrous PJ, Humphries A, Novelli M, Rodriguez-Justo M, Graham TA, McDonald SA et al. (2013). TWO DIMENSIONAL MAPPING OF MUTANT CLONES IN HUMAN COLONIC CRYPTS REVEAL STEM CELL DYNAMICS AND MIGRATION PATTERNS. GUT. vol. 62, A194-A195.

Zeki SS, Lovat L, Haidry RJ, Wright NA, McDonald SA (2013). Senescent Barrett's Epithelium Causes Proliferation of Neighbouring Non Senescent Epithelium by Paracrine Signalling. GASTROENTEROLOGY. vol. 144, S676-S677.

Wright NA, Khan S, McDonald SAC, Galandiuk S, Graham TA, Odze RD, Rodriguez-Justo M, Zeki S (2013). Crypt Cell Dysplasia with Maturation in Barrett's Esophagus Shows Clonal Identity between the Crypt and Surface Cells. JOURNAL OF PATHOLOGY. vol. 229, S6-S6.

Lavery D, Nicholson A, McDonald SAC, Jeffrey R, Jansen M, Wright NA (2013). Have We Got it Wrong about Barrett's Esophagus? Patterns of Gene Expression and Stem Cell Organisation Show Barrett's Glands to be a Unique Phenotype. JOURNAL OF PATHOLOGY. vol. 229, S18-S18.

Pan Q, Nicholson AM, Barr H, Harrison LA, Wilson GD, Burkert J, Jeffery R, Alison MR et al.(2013). Identification of lineage-uncommitted, long-lived, label-retaining cells in healthy human esophagus and stomach, and in metaplastic esophagus. Gastroenterology vol. 144, (4) 761-770.

Humphries A, Cereser B, Novelli M, Justo MR, Graham T, McDonald SAC, Wright NA (2012). Human Colorectal Adenoma Growth is Characterised by Periods of Quiesence and Rapid Clonal Expansion. JOURNAL OF PATHOLOGY. vol. 228, S16-S16.

Zeki S, Haidry R, Barr H, Shepherd N, Novelli M, Justo MR, Wright N, Lovat L et al. (2012). Recurrence After Radiofrequency Ablation for Barrett's Related High Grade Dysplasia is Due to Persistence of Epithelial Mutations. JOURNAL OF PATHOLOGY. vol. 228, S6-S6.

Jawad N, Graham T, Novelli M, Rodriguez-Justo M, Feakins R, Silver A, Wright N, McDonald S(2012). ARE PSEUDOPOLYPS THE SOURCE OF TUMORIGENIC MUTATIONS IN ULCERATIVE COLITIS?. GUT vol. 61, A236-A236.

Humphries A, Graham TA, Cereser B, McDonald SA, Wright NA(2012). HUMAN COLORECTAL ADENOMA GROWTH IS CHARACTERISED BY PERIODS OF QUIESCENCE AND RAPID CLONAL EXPANSION. GUT vol. 61, A7-A8.

Garcia TV, Rodriguez-Justo M, Graham T, Novelli M, Wright N, McDonald S(2012). THE CLONAL ORIGINS OF GASTRIC ADENOCARCINOMA. GUT vol. 61, A43-A44.

Khan S, Zeki S, Mitchell I, Harrison R, Dunn L, Leedham S, Barr H, Shepherd N et al.(2012). THE CLONAL PROGRESSION OF BARRETT'S OESOPHAGUS TO OESOPHAGEAL ADENOCARCINOMA. GUT vol. 61, A36-A37.

Zeki SS, Khan S, Graham TA, Leedham S, Barr H, Shepherd NA, Novelli M, Rodriguez-Justo M et al. (2012). Barretts Related Adenocarcinomas Arise as a Monoclonal Outgrowth From Polyclonal Dysplasia. GASTROENTEROLOGY. vol. 142, S643-S644.

Zeki SS, Haidry RJ, McDonald SA, Graham TA, Barr H, Shepherd NA, Novelli M, Rodriguez-Justo M et al. (2012). Recurrence After Radiofrequency Ablation for Barretts Related High Grade Dysplasia is Due to Persistence of Epithelial Mutations. GASTROENTEROLOGY. vol. 142, S750-S750.

Garcia TV, Rodriguez-Justo M, Graham TA, Novelli M, Wright NA, McDonald SA (2012). The Clonal Origins of Gastric Adenocarcinoma. GASTROENTEROLOGY. vol. 142, S643-S643.

McDonald S(2012). Bullying at Barts. Lancet vol. 379, (9825)

Galandiuk S, Rodriguez-Justo M, Jeffery R, Nicholson AM, Cheng Y, Oukrif D, Elia G, Leedham SJ et al.(2012). Field cancerization in the intestinal epithelium of patients with Crohn's ileocolitis. Gastroenterology vol. 142, (4) 855-864.e8.

Nicholson AM, Graham TA, Simpson A, Humphries A, Burch N, Rodriguez-Justo M, Novelli M, Harrison R et al.(2012). Barrett's metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor. Gut vol. 61, (10) 1380-1389.

McDonald S(2012). Reply: Bullying at Barts. The Lancet vol. 379, (9825)

Zeki S, Graham TA, McDonald SAC(2012). Utilizing DNA mutations to trace epithelial cell lineages in human tissues. Methods Mol Biol vol. 916, 289-301.

Zeki SS, McDonald SA, Graham TA(2011). Field cancerization in Barrett's esophagus. Discov Med vol. 12, (66) 371-379.

Gaisa NT, Graham TA, McDonald SA, Poulsom R, Heidenreich A, Jakse G, Knuechel R, Wright NA(2011). Clonal architecture of human prostatic epithelium in benign and malignant conditions. J Pathol vol. 225, (2) 172-180.

Gaisa NT, Graham TA, McDonald SAC, Cañadillas-Lopez S, Poulsom R, Heidenreich A, Jakse G, Tadrous PJ et al.(2011). The human urothelium consists of multiple clonal units, each maintained by a stem cell. J Pathol vol. 225, (2) 163-171.

Graham TA, McDonald SA, Wright NA(2011). Field cancerization in the GI tract. Future Oncol vol. 7, (8) 981-993.

Humphries A, Graham TA, Nicholson AM, McDonald SA, Wright NA (2011). Altered Stem Cell Dynamics in Human Colon Adenoma Crypts Allow Rapid Expansion and Fixation of Mutations During Clonal Expansion. GASTROENTEROLOGY. vol. 140, S13-S13.

Graham TA, McDonald SA, Humphries A, Wright NA(2011). The Life-Cycle of Human Colon Crypts. Gastroenterology vol. 140, (5) s-15.

Humphries A, Graham T, McDonald S, Wright N (2011). Altered stem cell dynamics in human colon adenoma crypts allow rapid expansion and fixation of mutations during clonal expansion. Gut. vol. 60,

Dunn JM, McDonald SA, Oukrif D, Haidry RJ, Butt MA, Lovat E, Lovat LB, Williams GH et al. (2011). PLK-1 IS UPREGULATED IN BARRETT'S ADENOCARCINOMA AND IS A SURROGATE MARKER OF ANEUPLOIDY. GUT. vol. 60,

Gutierrez-Gonzalez L, Graham TA, Rodriguez-Justo M, Leedham SJ, Novelli MR, Gay LJ, Ventayol-Garcia T, Green A et al.(2011). The clonal origins of dysplasia from intestinal metaplasia in the human stomach. Gastroenterology vol. 140, (4)

Graham TA, Humphries A, Sanders T, Rodriguez-Justo M, Tadrous PJ, Preston SL, Novelli MR, Leedham SJ et al.(2011). Use of methylation patterns to determine expansion of stem cell clones in human colon tissue. Gastroenterology vol. 140, (4)

Nicholson AM, Graham TA, Simpson A, Humphries A, Burch N, Rodriguez-Justo M, Novelli M, Harrison R et al.(2011). Barrett's metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor. Gut

Humphries A, Graham TA, McDonald SAC(2011). Stem cells and inflammation in the intestine. Recent Results Cancer Res vol. 185, 51-63.

Nicholson A, Graham T, Simpson A, Humphries A, Wright N, McDonald S, Jankowski J (2010). Analysis of the Clonality of Barrett's Oesophagus Glands Reveals They are Clonal Units and Establishes a Common Stem Cell for Glandular and Squamous Epithelium. JOURNAL OF PATHOLOGY. vol. 222, S17-S18.

Graham T, Galandiuk S, McDonald S, Leedham S, Wright N (2010). Field Cancerization in Crohn's Disease. JOURNAL OF PATHOLOGY. vol. 222, S15-S16.

Graham T, Khan S, Oukrif D, Green A, Jankowski J, Barr H, Novelli M, Shepherd N et al. (2010). Investigating Clonal Dynamics in Barrett's Associated tumorigenesis Using Spatial Maps of Genetic Heterogeneity. JOURNAL OF PATHOLOGY. vol. 222, S9-S9.

Nicholson A, Harrison L, Barr H, Graham T, McDonald S, Wright N, Harrison R, Jankowski J (2010). Pulse Chase Experiments Using IUdR Identifies Barrett's Label-Retaining Stem Cells. JOURNAL OF PATHOLOGY. vol. 222, S16-S16.

McDonald S, Jeffery R, Humphries A, Leedham S, Graham T, Segditsas S, Lewis A, Nicholson A et al. (2010). Stem Cell Location Throughout the Human Gastrointestinal Tract as Defined by LGR5 mRNA In Situ Hybridisation. JOURNAL OF PATHOLOGY. vol. 222, S12-S12.

Gutierrez-Gonzalez L, Graham TA, Rodriguez-Justo M, Green A, Gay LJ, Ventayol-Garcia T, Novelli M, Hashemi M et al. (2010). CLONAL ORIGINS OF DYSPLASIA FROM METAPLASIA IN THE HUMAN STOMACH. GUT. vol. 59, A17-A18.

Thirlwell C, Will OCC, Domingo E, Graham TA, McDonald SAC, Oukrif D, Jeffrey R, Gorman M et al.(2010). Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas. Gastroenterology vol. 138, (4) 1441-1454.e7.

Graham TA, McDonald SAC(2010). Genetic diversity during the development of Barrett's oesophagus-associated adenocarcinoma: how, when and why?. Biochem Soc Trans vol. 38, (2) 374-379.

Graham TA, Khan S, Green A, Oukrif D, Gay L, Barr H, Novelli M, Jankowski J et al. (2010). INVESTIGATING CLONAL COMPETITION IN BARRETT'S ASSOCIATED TUMORIGENESIS USING SPATIAL MAPS OF GENETIC HETEROGENEITY. GUT. vol. 59, A111-A111.

Nicholson AM, Graham TA, Simpson AI, Humphries A, Wright NA, McDonald SAC, Jankowski JA (2010). PWE-085 Analysis of the clonality of Barrett's oesophagus glands reveals they are clonal and establishes a common stem cell for glandular and squamous epithelium. Gut. vol. 59,

Lin W-R, Lim S-N, McDonald SAC, Graham T, Wright VL, Peplow CL, Humphries A, Kocher HM et al.(2010). The histogenesis of regenerative nodules in human liver cirrhosis. Hepatology vol. 51, (3) 1017-1026.

Alison MR, McDonald SAC, Lin WR, Wright NA(2010). Protection of Mitochondrial Genome Integrity: A New Stem Cell Property?. HEPATOLOGY vol. 51, (1) 354-354.

Preston S, Simpson A, Leedham S, McDonald S, Graham A, Graham T (2009). Transatlantic Barrett's Esophagus: Are We Divided By More Than the 'O'?. AMERICAN JOURNAL OF GASTROENTEROLOGY. vol. 104, S26-S26.

Alison MR, Fellous TG, McDonald SAC, Burkert J, Humphries A, Islam S, Gutierrez-Gonzalez L, Wright NA(2009). ECM X: A methodological approach to tracing cell lineage in human tissues. European Cells and Materials vol. 18, (SUPPL. 1)

McDonald SAC, Graham TA, Schier S, Wright NA, Alison MR(2009). Stem cells and solid cancers. VIRCHOWS ARCH vol. 455, (1) 1-13.

Lanza R, Hogan B, Gaerhart J, Melton D, Pedersen R(2009). Stem Cells in the Gastrointestinal Tract. Essentials of stem cell biology, Edition. 2nd, Academic Pr

Fellous TG, Islam S, Tadrous PJ, Elia G, Kocher HM, Bhattacharya S, Mears L, Turnbull DM et al.(2009). Locating the Stem Cell Niche and Tracing Hepatocyte Lineages in Human Liver. HEPATOLOGY vol. 49, (5) 1655-1663.

Humphries A, McDonald SA, Tadrous PJ, Wright NA (2009). Mapping Stem Cell Clones in Human Intestinal Crypts. GASTROENTEROLOGY. vol. 136, A78-A79.

Graham TA, Humphries A, McDonald SA, Leedham S, Wright NA (2009). Methylation and Clonality of Human Colonic Crypts. GASTROENTEROLOGY. vol. 136, A78-A78.

Gutierrez-Gonzalez L, Deheragoda M, Leedham SJ, Elia G, Shankar A, Imber C, Turnbull DM, Novelli M et al. (2009). HUMAN SMALL INTESTINAL CRYPTS ARE CLONAL, CONTAIN MULTIPLE STEM CELLS AND MUTATED CRYPTS DIVIDE BY FISSION. GUT. vol. 58, A2-A2.

Graham TA, Humphries A, Leedham SJ, McDonald SA, Wright NA (2009). METHODS FOR TRACING CRYPT STEM CELLS ANCESTRY AND CLONAL ARCHITECTURE USING CPG ISLAND METHYLATION AND MITOCHONDRIAL DNA MUTATIONS. GUT. vol. 58, A2-A2.

Gutierrez-Gonzalez L, Deheragoda M, Elia G, Leedham SJ, Shankar A, Imber C, Jankowski JA, Tumbull DM et al.(2009). Analysis of the clonal architecture of the human small intestinal epithelium establishes a common stem cell for all lineages and reveals a mechanism for the fixation and spread of mutations. J PATHOL vol. 217, (4) 489-496.

Leedham SJ, Graham TA, Oukrif D, McDonald SAC, Rodriguez-Justo M, Harrison RF, Shepherd NA, Novelli MR et al.(2009). Clonality, Founder Mutations, and Field Cancerization in Human Ulcerative Colitis-Associated Neoplasia. GASTROENTEROLOGY vol. 136, (2) 542-550.

Lovell M, Bhan C, Jankowski J, Mcdonald S(2009). Molecular Biology of Gastroesophageal Cancers: The Role of Mutational Analysis in Prognosis. 21-30.

Fellous TG, McDonald SAC, Burkert J, Humphries A, Islam S, De-Alwis NMW, Gutierrez-Gonzalez L, Tadrous PJ et al.(2009). A Methodological Approach to Tracing Cell Lineage in Human Epithelial Tissues. STEM CELLS vol. 27, (6) 1410-1420.

McDonald SAC, Graham TA, Humphries A, Wright NA, Preston SL, Brittan M, Direkze NC(2009). Chapter 36 Stem Cells in the Gastrointestinal Tract. Essentials of Stem Cell Biology,

Milicic A, Harrison LA, Goodlad RA, Hardy RG, Nicholson AM, Presz M, Sieber O, Santander S et al.(2008). Ectopic expression of P-cadherin correlates with promoter hypomethylation early in colorectal carcinogenesis and enhanced intestinal crypt fission in vivo. CANCER RES vol. 68, (19) 7760-7768.

Leedham SJ, Preston SL, McDonald SAC, Elia G, Bhandari P, Poller D, Harrison R, Novelli MR et al.(2008). Individual crypt genetic heterogeneity and the origin of metaplastic glandular epithelium in human Barrett's oesophagus. GUT vol. 57, (8) 1041-1048.

Mcdonald SAC, Greaves LC, Gutierrez-Gonzalez L, Rodriguez-Justo M, Deheragoda M, Leedham SJ, Taylor RW, Lee CY et al.(2008). Mechanisms of field cancerization in the human stomach: The expansion and spread of mutated gastric stem cells. GASTROENTEROLOGY vol. 134, (2) 500-510.

Jankowski J, Sampliner R, Kerr D, Fong Y(2008). Gastrointestinal Oncology: A Critical Multidisciplinary Approach: A Critical Multidisciplinary Team Approach. Molecular Biology of Gastroesophageal Cancers: the Role of Mutational Analysis in Prognosis, Wiley-Blackwell

McDonald SAC, Gutierrez-Gonzalez L, Rodriguez-Justo M, Leedham SJ, Novelli M, Mitchell I, Stoker D, Jankowski JA et al. (2008). The fixation of mutations and clonal expansion in intestinal metaplasia: Field cancerisation in the human stomach. GUT. vol. 57, A32-A32.

Fellous TG, Britian M, Kocher H, Bhattacharya S, Tadrous PJ, Taylor GA, Greaves LC, Mcdonald SA et al. (2007). Mitochondrial DNA mutations to investigate cell lineage relations in human liver. GASTROENTEROLOGY. vol. 132, A830-A830.

Pollard PJ, Spencer-Dene B, Shukla D, Howarth K, Nye E, El-Bahrawy M, Deheragoda M, Joannou M et al.(2007). Targeted inactivation of Fh1 causes proliferative renal cyst development and activation of the hypoxia pathway. CANCER CELL vol. 11, (4) 311-319.

McDonald SAC, Leedham SJ, Greaves LC, Oulcrif D, Novelli MR, Deheragoda M, Turnbull DM, Jankowski JAZ et al. (2006). Modelling of the expansion of normal human colonic crypts. JOURNAL OF PATHOLOGY. vol. 210, 15-15.

Leedham SJ, Maia LC, Seiber O, Preston SL, McDonald SAC, Tomlinson IPA, Novelli MR, Wright NA (2006). The clonal origin of human tumours: is familial adenomatous polyposis (FAP) different?. JOURNAL OF PATHOLOGY. vol. 210, 54-54.

Deheragoda MG, Leedham SJ, Brittan M, Direkze NC, Preston SL, Stoker DLS, Novelli MR, McDonald SAC et al. (2006). The role of the periglandular myofbroblast sheath in gastric carcinogenesis. JOURNAL OF PATHOLOGY. vol. 210, 12-12.

McDonald SAC, Preston SL, Lovell MJ, Wright NA, Jankowski JAZ(2006). Mechanisms of disease: from stem cells to colorectal cancer. NAT CLIN PRACT GASTR vol. 3, (5) 267-274.

McDonald SAC, Preston SL, Greaves LC, Leedham SJ, Lovell MA, Jankowski JAZ, Turnbull DM, Wright NA(2006). Clonal expansion in the human gut - Mitochondrial DNA mutations show us the way. CELL CYCLE vol. 5, (8) 808-811.

McDonald S, Atherfold PA, Obszynska J, Hardy RG, Sanders S, Harrison R, Rowan A, Tomlinson IP et al. (2006). A CPG island within the P-cadherin promoter is hypomethylated early during colorectal tumourigenesis: Biological consequences. GASTROENTEROLOGY. vol. 130, A716-A716.

Leedham SJ, Maia LC, Sieber O, Preston SL, McDonald SAC, Tomlinson IPM, Wright NA (2006). Evidence of monoclonal origins in dysplasia in ulcerative colitis. GUT. vol. 55, A16-A16.

McDonald SAC, Greaves LG, Leedham SJ, Yin-Lee C, Deheragoda M, Oukrif D, Novelli MR, Taylor RW et al. (2006). Monoclonal conversion of human gastric glands provides insights into stem cell and clonal architecture. GUT. vol. 55, A28-A28.

Leedham SJ, Deheragoda MG, Brittan M, Direkze NC, Preston SL, McDonald SAC, Wright NA (2006). The stomach peri-glandular fibroblast sheath expands in inflamed tissue before development of intestinal metaplasia. GUT. vol. 55, A30-A30.

Leedham SJ, Sieber O, Preston SL, McDonald SAC, Tomlinson IPM, Wright NA (2006). Evidence of monoclonal origins in dysplasia in ulcerative colitis. JOURNAL OF PATHOLOGY. vol. 208, 1A-1A.

McDonald S, Greaves LG, Leedham SJ, Preston SL, Taylor RW, Oukrif D, Deheragoda M, Novelli MR et al. (2006). Monoclonal conversion in human gastric glands: Insights into stem cell and clonal architecture. JOURNAL OF PATHOLOGY. vol. 208, 29A-29A.

Leedham SJ, Brittan M, Preston SL, McDonald SAC, Deheragoda M, Wright NA (2006). The human and mouse gastric glands do possess a periglandular myofibroblastic sheath. JOURNAL OF PATHOLOGY. vol. 208, 16A-16A.

Leedham SJ, Brittan M, Preston SL, McDonald SAC, Wright NA(2006). The stomach periglandular fibroblast sheath: all present and correct. Gut vol. 55, (2) 295-296.

Greaves LC, Preston SL, Tadrous PJ, Taylor RW, Barron MJ, Oukrif D, Leedham SJ, Deheragoda M et al.(2006). Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission. P NATL ACAD SCI USA vol. 103, (3) 714-719.

McDonald SAC, Graham T, Potten CS, Wright NA, Tomlinson IPM, Renehan AG(2006). Intestinal stem cells and the development of colorectal neoplasia. Tissue Stem Cells,

Leedham SJ, Brittan M, Preston SL, MCDONALD S, Wright NA(2006). The stomach periglandular sheath: All present and correct. Gut vol. 55, (2) 295-296.

Potten CS, Clarke RB, Wilson J(2006). Tissue stem cells. Informa HealthCare

Preston SL, McDonald SAC, Oukrif D, Greaves L, Turnbull D, Tadrous P, Sasieni P, Jankowski JA et al. (2005). Clusters of phenotypically related human colonic crypts develop through crypt fission: Implications for colorectal carcinogenesis. GUT. vol. 54, A24-A24.

McDonald SAC, Preston SL, Greaves L, Tadrous P, Saseini P, Novelli M, Oukriff D, Jankowski J et al. (2005). Clusters of phenotypically-related human colonic crypts develop through crypt fission: Implications for colorectal carcinogenesis. JOURNAL OF PATHOLOGY. vol. 205, 2-2.

Leedham SJ, Brittan M, McDonald SAC, Wright NA(2005). Intestinal stem cells. J Cell Mol Med vol. 9, (1) 11-24.

McDonald SAC, O'Grady JE, Bajaj-Elliott M, Notley CA, Alexander J, Brombacher F, McDonald V(2004). Protection against the early acute phase of Cryptosporidium parvum infection conferred by interleukin-4-induced expression of T helper 1 cytokines. JOURNAL OF INFECTIOUS DISEASES vol. 190, (5) 1019-1025.

Irving P, Lean S, Wood AJ, McDonald SA, Seward EM, Rampton DS (2004). Poster presentations at national and international gastroenterology conferences are of limited value. GASTROENTEROLOGY. vol. 126, A436-A436.

Lean IS, McDonald SAC, Bajaj-Elliott M, Pollok RCG, Farthing MJG, McDonald V(2003). Interleukin-4 and transforming growth factor beta have opposing regulatory effects on gamma interferon-mediated inhibition of Cryptosporidium parvum reproduction. INFECT IMMUN vol. 71, (8) 4580-4585.

McDonald SAC, Bajaj-Elliott M, Smith PT, Ballinger AB, McDonald V (2003). Immunity to Cryptosporidium parvum: A role for IL-4 in the early adaptive immune response. GUT. vol. 52, A55-A56.

Lean IS, McDonald SAC, McDonald V (2003). Tumour necrosis factor alpha mediates resistance to Cryptosporidium parvum infection in enterocyte cell lines but is not required for protection in a mouse model of infection. GUT. vol. 52, A56-A56.

Higgins LM, McDonald SA, Whittle N, Crockett N, Shields JG, MacDonald TT(1999). Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an OX40 ligand-IgG fusion protein. J Immunol vol. 162, (1) 486-493.

Higgins LM, McDonald SAC, Shields JG, Timans J, Whittle N, MacDonald TT(1998). An OX40 fusion protein prevents colitis in mice. GASTROENTEROLOGY vol. 114, (4) A995-A995.

Roy-Chaudhury P, Hillis G, MCDONALD S, Simpson JG, Power DA(1997). Importance of the tubulointerstitium in human glomerulonephritis. II. Distribution of integrin chains beta 1, alpha 1 to 6 and alpha V. Kidney Int vol. 52, (1) 103-110.

McDonald SA, Palmen MJ, Van Rees EP, MacDonald TT(1997). Characterization of the mucosal cell-mediated immune response in IL-2 knockout mice before and after the onset of colitis. Immunology vol. 91, (1) 73-80.

Palmen MJHJ, McDonald SAC, vanRees EP, MacDonald TT(1996). Non-lymphoid and lymphoid cells and their cytokine profiles in IL-2 knock-out mice. GASTROENTEROLOGY vol. 110, (4) A986-A986.

Roy-Chaudhury P, Wu B, MCDONALD S, Haites NE, Simpson JG, Power DA(1995). Phenotypic analysis of the glomerular and periglomerular mononuclear cell infiltrates in the Thy 1.1 model of glomerulonephritis. Lab Invest vol. 72, (5) 524-531.