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Publications:  Prof David Lee

Rice A, Cortes E, Lachowski D, Oertle P, Matellan C, Thorpe SD, Ghose R, Wang H et al.(2020). GPER activation inhibits cancer cell mechanotransduction and basement membrane invasion via RhoA. Cancers vol. 12, (2)
10.3390/cancers12020289
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62752
Thorpe S, Chronopoulos A, Cortes E, Lachowski D, Rice A, Mykuliak V, Róg T, Lee D et al.(2020). Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathway. Nature Materials
10.1038/s41563-019-0567-1
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62314
Cortes E, Sarper M, Robinson B, Lachowski D, Chronopoulos A, Thorpe SD, Lee DA, del Río Hernández AE(2019). GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment. EMBO Reports vol. 20, (1)
10.15252/embr.201846556
https://qmro.qmul.ac.uk/xmlui/handle/123456789/54143
Cortes E, Lachowski D, Robinson B, Sarper M, Teppo JS, Thorpe SD, Lieberthal TJ, Iwamoto K et al.(2019). Tamoxifen mechanically reprograms the tumor microenvironment via HIF-1A and reduces cancer cell survival. EMBO Reports vol. 20, (1)
10.15252/embr.201846557
https://qmro.qmul.ac.uk/xmlui/handle/123456789/54144
Cortes E, Lachowski D, Rice A, THORPE SD, Robinson B, Yeldag G, LEE DA, Ghemtio L et al.(2018). Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor. Oncogene
10.1038/s41388-018-0631-3
https://qmro.qmul.ac.uk/xmlui/handle/123456789/54955
Cortes E, Lachowski D, Rice A, Chronopoulos A, Robinson B, THORPE SD, LEE DA, Possamai LA et al.(2018). RAR‐β is downregulated in HCC & cirrhosis and its expression inhibits myosin‐driven activation and durotaxis in hepatic stellate cells. Hepatology
10.1002/hep.30193
https://qmro.qmul.ac.uk/xmlui/handle/123456789/42827
Heywood HK, Thorpe SD, Jeropoulos RM, Lee DA (2017). Small molecule activators of SIRT1 augment the regenerative potential of chondrocytes for cell-based cartilage repair techniques. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 98, A14-A14.
Panesar KS, Thorpe SD, Lee DA (2017). Uniaxial tensile strain modulates mesenchymal stem cell nuclear structure and histone methylation in a differentiation dependent manner. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 98, A11-A12.
Elyasigomari V, Lee DA, Screen HRC, SHAHEED MH(2017). Development of a two-stage gene selection method that incorporates a novel hybrid approach using the cuckoo optimization algorithm and harmony search for cancer classification. Journal of Biomedical Informatics vol. 67, (2017) 11-20.
10.1016/j.jbi.2017.01.016
https://qmro.qmul.ac.uk/xmlui/handle/123456789/19281
THORPE SD, Lee DA(2017). Dynamic regulation of nuclear architecture and mechanics—a rheostatic role for the nucleus in tailoring cellular mechanosensitivity. Nucleus vol. 8, (3) 287-300.
10.1080/19491034.2017.1285988
https://qmro.qmul.ac.uk/xmlui/handle/123456789/19087
Eraifej J, Thorpe SD, Martins RP, Lee DA (2017). Does lamin A/C play a role in neuronal differentiation?. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 98, A12-A12.
https://qmro.qmul.ac.uk/xmlui/handle/123456789/24788
Thorpe SD, Oti A, Mauck RL, Lee DA (2017). Stem cell differentiation state modulates Lamin AC localization and phosphorylation in response to cyclic tensile strain. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 98, A13-A14.
https://qmro.qmul.ac.uk/xmlui/handle/123456789/24787
Heywood HK, Caton PW, Lee DA (2016). SIRT1, an enzyme vital to cartilage homeostasis, is regulated by osmolarity and glucose levels. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 97, A2-A2.
Heo S-J, Driscoll TP, Thorpe SD, Nerurkar NL, Baker BM, Yang MT, Chen CS, Lee DA et al.(2016). Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity. eLife vol. 5,
10.7554/eLife.18207
https://qmro.qmul.ac.uk/xmlui/handle/123456789/18193
Tilwani RK, Vessillier S, Pingguan-Murphy B, Lee DA, Bader DL, Chowdhury TT(2016). Oxygen tension modulates the effects of TNFα in compressed chondrocytes. Inflamm Res
10.1007/s00011-016-0991-5
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15889
Heo SJ, Han WM, Szczesny SE, Cosgrove BD, Elliott DM, Lee DA, Duncan RL, Mauck RL(2016). Mechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells. Biophysical Journal vol. 111, (4) 864-874.
10.1016/j.bpj.2016.07.006
https://qmro.qmul.ac.uk/xmlui/handle/123456789/13897
Heywood HK, Lee DA(2016). Bioenergetic reprogramming of articular chondrocytes by exposure to exogenous and endogenous reactive oxygen species and its role in the anabolic response to low oxygen. Journal of Tissue Engineering and Regenerative Medicine vol. 11, (8) 2286-2294.
10.1002/term.2126
https://qmro.qmul.ac.uk/xmlui/handle/123456789/11136
Sliogeryte K, Botto L, Lee DA, Knight MM(2016). Chondrocyte dedifferentiation increases cell stiffness by strengthening membrane-actin adhesion. Osteoarthritis and Cartilage vol. 24, (5) 912-920.
10.1016/j.joca.2015.12.007
https://qmro.qmul.ac.uk/xmlui/handle/123456789/10785
Theocharidis G, Drymoussi Z, Kao AP, Barber AH, Lee DA, Braun KM, Connelly JT(2016). Type VI Collagen Regulates Dermal Matrix Assembly and Fibroblast Motility. J Invest Dermatol vol. 136, (1) 74-83.
10.1038/JID.2015.352
https://qmro.qmul.ac.uk/xmlui/handle/123456789/19741
Theocharidis G, Drymoussi Z, Kao AP, Barber AH, Lee DA, Braun KM, Connelly JT(2016). Type VI collagen regulates dermal matrix assembly and fibroblast motility. Journal of Investigative Dermatology vol. 136, (1) 74-83.
10.1038/JID.2015.352
https://qmro.qmul.ac.uk/xmlui/handle/123456789/11134
Heo SJ, Thorpe SD, Driscoll TP, Duncan RL, Lee DA, Mauck RL(2015). Biophysical regulation of chromatin architecture instills a mechanical memory in mesenchymal stem cells. Scientific Reports vol. 5,
10.1038/srep16895
https://qmro.qmul.ac.uk/xmlui/handle/123456789/11133
Chen J, Bader DL, Lee DA, Knight MM(2015). FINITE ELEMENT ANALYSIS of MECHANICAL DEFORMATION of CHONDROCYTE to 2D SUBSTRATE and 3D SCAFFOLD. Journal of Mechanics in Medicine and Biology vol. 15, (5)
10.1142/S0219519415500773
Tilwani RK, Lee DA, Pingguan-Murphy B, Abas WABW, Chowdhury TT (2014). Hypoxia amplified catabolic effects induced by TNF alpha in chondrocytes - response reduced with biomechanical signals. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 95, A33-A34.
Thorpe SD, Lee DA (2014). Mesenchymal stem cell nuclear architecture is differentially regulated by lineage commitment and mechanical stimulation. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 95, A33-A33.
Heywood HK, Lee DA (2014). Reactive oxygen species drive the transformation to an oxidative energy metabolism in cultured articular chondrocytes. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 95, A15-A16.
Irianto J, Lee DA, Knight MM(2014). Quantification of chromatin condensation level by image processing. Med Eng Phys vol. 36, (3) 412-417.
10.1016/j.medengphy.2013.09.006
Heywood HK, Nalesso G, Lee DA, Dell'accio F(2014). Culture expansion in low-glucose conditions preserves chondrocyte differentiation and enhances their subsequent capacity to form cartilage tissue in three-dimensional culture. Biores Open Access vol. 3, (1) 9-18.
10.1089/biores.2013.0051
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12684
Sliogeryte K, Thorpe SD, Lee DA, Botto L, Knight MM(2014). Stem cell differentiation increases membrane-actin adhesion regulating cell blebability, migration and mechanics. Scientific Reports vol. 4,
10.1038/srep07307
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6929
Irianto J, Swift J, Martins RP, McPhail GD, Knight MM, Discher DE, Lee DA(2013). Osmotic challenge drives rapid and reversible chromatin condensation in chondrocytes. Biophys J vol. 104, (4) 759-769.
10.1016/j.bpj.2013.01.006
Pattappa G, Thorpe SD, Jegard NC, Heywood HK, de Bruijn JD, Lee DA(2013). Continuous and Uninterrupted Oxygen Tension Influences the Colony Formation and Oxidative Metabolism of Human Mesenchymal Stem Cells. TISSUE ENGINEERING PART C-METHODS vol. 19, (1)
10.1089/ten.tec.2011.0734
https://qmro.qmul.ac.uk/xmlui/handle/123456789/36242
Chen J, Irianto J, Inamdar S, Pravincumar P, Lee DA, Bader DL, Knight MM(2012). Cell mechanics, structure, and function are regulated by the stiffness of the three-dimensional microenvironment. Biophys J vol. 103, (6) 1188-1197.
10.1016/j.bpj.2012.07.054
Bonzani IC, Campbell JJ, Knight MM, Williams A, Lee DA, Bader DL, Stevens MM(2012). Dynamic compressive strain influences chondrogenic gene expression in human periosteal cells: a case study. J Mech Behav Biomed Mater vol. 11, 72-81.
10.1016/j.jmbbm.2011.06.015
Branford OA, Lee DA, Rolfe KJ, Grobbelaar AO(2012). The attachment of intrinsic and extrinsic, mobilized and immobilized adhesion cells to collagen and fibronectin. Journal of Hand Surgery: European Volume vol. 37, (6) 564-572.
10.1177/1753193411428994
Branford OA, Lee DA, Bader DL, Grobbelaar AO(2012). The mechanics of flexor tendon adhesions. Journal of Hand Surgery: European Volume vol. 37, (6) 555-563.
10.1177/1753193411432675
Maeda E, Ye S, Wang W, Bader DL, Knight MM, Lee DA(2012). Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading. Biomechanics and Modeling in Mechanobiology vol. 11, (3-4) 439-447.
10.1007/s10237-011-0323-1
Martins RP, Finan JD, Guilak F, Lee DA(2012). Mechanical regulation of nuclear structure and function. Annu Rev Biomed Eng vol. 14, 431-455.
10.1146/annurev-bioeng-071910-124638
Hosny NA, Lee DA, Knight MM(2012). Single photon counting fluorescence lifetime detection of pericellular oxygen concentrations. J Biomed Opt vol. 17, (1)
10.1117/1.JBO.17.1.016007
Pattappa G, Heywood HK, de Bruijn JD, Lee DA(2011). The metabolism of human mesenchymal stem cells during proliferation and differentiation. J Cell Physiol vol. 226, (10) 2562-2570.
10.1002/jcp.22605
Lewinsohn AD, Anssari-Benham A, Lee DA, Taylor PM, Chester AH, Yacoub MH, Screen HRC(2011). Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment. Proc Inst Mech Eng H vol. 225, (8) 821-830.
10.1177/0954411911406340
Lewinsohn AD, Anssari-Benham A, Lee DA, Taylor PM, Chester AH, Yacoub MH, Screen HRC(2011). Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment. P I MECH ENG H vol. 225, (H8) 821-830.
10.1177/0954411911406340
Martyn SV, Heywood HK, Rockett P, Paine MD, Wang MJ, Dobson PJ, Sheard SJ, Lee DA et al.(2011). Electrospray deposited fibronectin retains the ability to promote cell adhesion. Journal of Biomedical Materials Research - Part B Applied Biomaterials vol. 96 B, (1) 110-118.
10.1002/jbm.b.31745
Chen J, Bader DL, Lee DA, Knight MM (2011). Finite Element Modeling of Cell Deformation When Chondrocyte Seeded Agarose Is Subjected to Compression. 8TH INTERNATIONAL CONFERENCE ON CELL & STEM CELL ENGINEERING (ICCE). vol. 30, 17-20.
10.1007/978-3-642-19044-5_5
Maeda E, Ye S, Wang W, Bader DL, Knight MM, Lee DA(2011). Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading. Biomechanics and Modeling in Mechanobiology1-9.
10.1007/s10237-011-0323-1
Lee DA, Brand J, Salter D, Akanji O-O, Chowdhury TT(2011). Quantification of mRNA using real-time PCR and Western blot analysis of MAPK events in chondrocyte/agarose constructs. Methods Mol Biol vol. 695, 77-97.
10.1007/978-1-60761-984-0_6
Lee DA, Knight MM, Campbell JJ, Bader DL(2011). Stem cell mechanobiology. J Cell Biochem vol. 112, (1) 1-9.
10.1002/jcb.22758
Pattappa G, Heywood HK, de Bruijn JD, Lee DA(2010). The metabolism of human mesenchymal stem cells during proliferation and differentiation. J Cell Physiol
10.1002/jcp.22605
Maeda E, Fleischmann C, Mein CA, Shelton JC, Bader DL, Lee DA(2010). Functional analysis of tenocytes gene expression in tendon fascicles subjected to cyclic tensile strain. Connective Tissue Research vol. 51, (6) 434-444.
10.3109/03008201003597056
Heywood HK, Knight MM, Lee DA(2010). Both superficial and deep zone articular chondrocyte subpopulations exhibit the crabtree effect but have different basal oxygen consumption rates. Journal of Cellular Physiology vol. 223, (3) 630-639.
10.1002/jcp.22061
Hosny NA, Lee DA, Knight MM (2010). Extracellular oxygen concentration mapping with confocal multiphoton laser scanning microscope and TCSPC card. MULTIPHOTON MICROSCOPY IN THE BIOMEDICAL SCIENCES X. Editors: Periasamy, A, So, PTC, Konig, K, vol. 7569,
10.1117/12.842281
Heywood HK, Lee DA(2010). Low oxygen reduces the modulation to an oxidative phenotype in monolayer-expanded chondrocytes. J Cell Physiol vol. 222, (1) 248-253.
10.1002/jcp.21946
Maeda E, Shelton JC, Bader DL, Lee DA(2009). Effect of intermittent cyclic tensile strain on collagen synthesis by tenocytes in isolated fascicles. Journal of Biomechanical Science and Engineering vol. 4, (4) 510-517.
10.1299/jbse.4.510
Pattappa G, Jegard NC, Lee DA, de Bruijn JD(2009). The effect of oxygen tension on the proliferation and differentiation of human mesenchymal stem cells. European Cells and Materials vol. 18, (SUPPL. 1)
Mcleod R, Pattappa G, Irianto J, Awan M, Knight MM, Lee DA (2009). Graded hydrogel constructs for cartilage tissue engineering. European Cells and Materials. vol. 18,
Campbell JJ, Maeda E, Ye SJ, Wang W, Lee DA(2009). Osteogenic differentiation of human mesenchymal stem cells within a perfused bioreactor system. European Cells and Materials vol. 18, (SUPPL. 2)
Pattappa G, Jegard NC, de Bruijn JD, Lee DA(2009). The influence of oxygen tension on the colony formation and proliferation of human mesenchymal stem cells. European Cells and Materials vol. 18, (SUPPL. 2)
Maeda E, Shelton JC, Bader DL, Lee DA(2009). Differential regulation of gene expression in isolated tendon fascicles exposed to cyclic tensile strain in vitro. Journal of Applied Physiology vol. 106, (2) 506-512.
10.1152/japplphysiol.90981.2008
Berry CC, Shelton JC, Lee DA(2009). Cell-generated forces influence the viability, metabolism and mechanical properties of fibroblast-seeded collagen gel constructs. J Tissue Eng Regen Med vol. 3, (1) 43-53.
10.1002/term.133
Eniwumide JO, Lee DA, Bader DL(2009). The development of a bioreactor to perfuse radially-confined hydrogel constructs: design and characterization of mass transport properties. Biorheology vol. 46, (5) 417-437.
10.3233/BIR-2009-0552
Heywood HK, Lee DA(2008). Monolayer expansion induces an oxidative metabolism and ROS in chondrocytes. Biochem Biophys Res Commun vol. 373, (2) 224-229.
10.1016/j.bbrc.2008.06.011
Maeda E, Shelton JC, Bader DL, Lee DA(2008). Collagen synthesis by tenocytes in fascicles subjected to intermittent cyclic strain. European Cells and Materials vol. 16, (SUPPL. 3)
Chowdhury TT, Salter DM, Bader DL, Lee DA(2008). Signal transduction pathways involving p38 MAPK, JNK, NF kappa B and AP-1 influences the response of chondrocytes cultured in agarose constructs to IL-1 beta and dynamic compression. INFLAMM RES vol. 57, (7) 306-313.
10.1007/s00011-007-7126-y
Heywood HK, Lee DA(2008). The effect of oxygen supply on chondrocyte metabolic phenotype during monolayer culture. European Cells and Materials vol. 16, (SUPPL. 3)
Chowdhury TT, Arghandawi S, Brand J, Akanji OO, Bader DL, Salter DM, Lee DA(2008). Dynamic compression counteracts IL-1beta induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs. Arthritis Res Ther vol. 10, (2)
10.1186/ar2389
https://qmro.qmul.ac.uk/xmlui/handle/123456789/13689
Chowdhury TT, Akanji OO, Salter DM, Bader DL, Lee DA(2008). Dynamic compression influences interleukin-1 beta-induced nitric oxide and prostaglandin E-2 release by articular chondrocytes via alterations in iNOS and COX-2 expression. BIORHEOLOGY vol. 45, (3-4) 257-274.
10.3233/BIR-2008-0474
Campbell JJ, Bader DL, Lee DA(2008). Mechanical loading modulates intracellular calcium signaling in human mesenchymal stem cells. J APPL BIOMATER BIOM vol. 6, (1) 9-15.
Akanji OO, Lee DA, Bader DA (2008). The effects of direct current stimulation on isolated chondrocytes seeded in 3D agarose constructs. BIORHEOLOGY. vol. 45, 229-243.
10.3233/BIR-2008-0473
Maeda E, Shelton JC, Bader DL, Lee DA(2007). Time dependence of cyclic tensile strain on collagen production in tendon fascicles. BIOCHEM BIOPH RES CO vol. 362, (2) 399-404.
10.1016/j.bbrc.2007.08.029
Bonzani IC, Knight MM, Lee DA, Bader DL, Williams A, Stevens MM (2007). A model for studying the influence of mechanical loading on human periosteal stem cells. TISSUE ENGINEERING. vol. 13, 1636-1636.
Heywood HK, Lee DA (2007). Development of an immunoassay for determination of adsorbed fibronectin levels on bio-functionalised substrates. TISSUE ENGINEERING. vol. 13, 1669-1670.
Chowdhury TT, Akanji OO, Arghandawi, Salter DM, Bader DL, Lee DA (2007). Dynamic compression counteracts IL-1 beta b induced iNOS and COX-2 expression in chondrocytes cultured in agarose constructs. TISSUE ENGINEERING. vol. 13, 1677-1677.
Maeda E, Shelton JC, Bader DL, Lee DA (2007). Gene expressions in tendon fascicles subjected to cyclic tensile strain. TISSUE ENGINEERING. vol. 13, 1701-1701.
Campbell JJ, Bader DL, Lee DA (2007). Mechanical loading modulates calcium signalling within mesenchymal stem cells. TISSUE ENGINEERING. vol. 13, 1722-1723.
Pattappa G, De Bruijn JD, Lee DA (2007). Mesenchymal stem cells maintain a glycolytic metabolism under normoxic conditions. TISSUE ENGINEERING. vol. 13, 1725-1725.
Mcleod R, Pattappa G, Irianto J, Knight MM, Lee DA (2007). The development and characterisation of chondrocyte-seeded gradient hydrogel constructs for cartilage tissue engineering. TISSUE ENGINEERING. vol. 13, 1763-1763.
Heywood HK, Bader DL, Lee DA (2006). Glucose concentration and medium volume influence cell viability and glycosaminoglycan synthesis in chondrocyte-seeded alginate constructs. Tissue Eng. vol. 12, 3487-3496.
10.1089/ten.2006.12.3487
Screen HRC, Chhaya VH, Greenwald SE, Bader DL, Lee DA, Shelton JC(2006). The influence of swelling and matrix degradation on the microstructural integrity of tendon. Acta Biomater vol. 2, (5) 505-513.
10.1016/j.actbio.2006.05.008
Knight MM, Bomzon Z, Kimmel E, Sharma AM, Lee DA, Bader DL(2006). Chondrocyte deformation induces mitochondrial distortion and heterogeneous intracellular strain fields. BIOMECH MODEL MECHAN vol. 5, (2-3) 180-191.
10.1007/s10237-006-0020-7
Akanji OO, Bader DL, Lee DA(2006). Direct current influences Ca <sup>2+</sup> signalling in chondrocytes. European Cells and Materials vol. 11, (SUPPL.2)
Chowdhury TT, Appleby RN, Salter DM, Bader DA, Lee DA(2006). Integrin-mediated mechanotransduction in IL-1 beta stimulated chondrocytes. Biomech Model Mechanobiol vol. 5, (2-3) 192-201.
10.1007/s10237-006-0032-3
Enobakhare B, Bader DL, Lee DA(2006). Concentration and M/G ratio influence the physiochemical and mechanical properties of alginate constructs for tissue engineering. J Appl Biomater Biomech vol. 4, (2) 87-96.
Heywood HK, Bader DL, Lee DA(2006). Rate of oxygen consumption by isolated articular chondrocytes is sensitive to medium glucose concentration. Journal of Cellular Physiology vol. 206, (2) 402-410.
10.1002/jcp.20491
Chowdhury TT, Bader DL, Lee DA(2006). Anti-inflammatory effects of IL-4 and dynamic compression in IL-1beta stimulated chondrocytes. Biochem Biophys Res Commun vol. 339, (1) 241-247.
10.1016/j.bbrc.2005.11.016
Chowdhury TT, Bader DL, Lee DA(2006). Dynamic compression counteracts IL-1beta induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs. Biorheology vol. 43, (3,4) 413-429.
Campbell JJ, Lee DA, Bader DL (2006). Dynamic compressive strain influences chondrogenic gene expression in human mesenchymal stem cells. BIORHEOLOGY. vol. 43, 455-470.
Knight MM, Toyoda T, Lee DA, Bader DL(2006). Mechanical compression and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose. J Biomech vol. 39, (8) 1547-1551.
10.1016/j.jbiomech.2005.04.006
Pingguan-Murphy B, Lee DA, Bader DL, Knight MM(2005). Activation of chondrocytes calcium signalling by dynamic compression is independent of number of cycles. Arch Biochem Biophys vol. 444, (1) 45-51.
10.1016/j.abb.2005.09.015
Screen HRC, Bader DL, Shelton JC, Lee DA(2005). Cyclic mechanical conditioning of isolated tendon fascicles results in an upregulation of collagen production. Proceedings of the 2005 Summer Bioengineering Conference vol. 2005, 193-194.
Pingguan B, Lee DA, Bader DL, Knight MM (2005). Dynamic compression activates chondrocyte calcium signaling in a cycle dependent manner involving the release of ATP. Proceedings of the 2005 Summer Bioengineering Conference. vol. 2005, 223-224.
Chowdhury TT, Bader DL, Lee DA(2005). Dynamic compression counteracts IL-1-induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs. Proceedings of the 2005 Summer Bioengineering Conference vol. 2005, 251-252.
Wang MJ, Heywood HK, Bader DL, Paine MD, Stark JPW, Lee DA(2005). Identification and characterization of deposited fibronectin on biocompatible materials: Comparison of electrospray and wetting methods. Proceedings of the 2005 Summer Bioengineering Conference vol. 2005, 439-440.
Chowdhury TT, Appleby RN, Salter DA, Bader DL, Lee DA(2005). Integrin mediated mechanotransduction in IL-1 stimulated bovine chondrocytes cultured in agarose constructs. Proceedings of the 2005 Summer Bioengineering Conference vol. 2005, 545-546.
Bader DL, Lee DA(2005). Mechanical conditioning of cell-seeded constructs for soft tissue repair - Are optimisation strategies possible?. 165-192.
10.1007/1-4020-3741-4_7
Screen HRC, Shelton JC, Bader DL, Lee DA(2005). Cyclic tensile strain upregulates collagen synthesis in isolated tendon fascicles. Biochem Biophys Res Commun vol. 336, (2) 424-429.
10.1016/j.bbrc.2005.08.102
Sengers BG, Heywood HK, Lee DA, Oomens CWJ, Bader DL(2005). Nutrient utilization by bovine articular chondrocytes: a combined experimental and theoretical approach. J Biomech Eng vol. 127, (5) 758-766.
10.1115/1.1993664
Screen HRC, Shelton JC, Chhaya VH, Kayser MV, Bader DL, Lee DA(2005). The influence of noncollagenous matrix components on the micromechanical environment of tendon fascicles. Ann Biomed Eng vol. 33, (8) 1090-1099.
10.1007/s10439-005-5777-9
Chowdhury TT, Bader DL, Lee DA(2005). Dynamic compression counteracts IL-1β induced INOS and COX-2 activity by human chondrocytes cultured in agarose constructs. European Cells and Materials vol. 10, (SUPPL.2)
Catuogno C, Chowdhury TT, Bader DL, Lee DA(2005). Dynamic compression influences the biochemical response of human mesenchymal stem cells cultured in agarose constructs. European Cells and Materials vol. 10, (SUPPL.2)
Pingguna B, Lee DA, Bader DL, Knight MM (2005). Mechanical compression activates chondrocyte Calcium signalling in a cycle dependent Manner Involving the release of ATP. European Cells and Materials. vol. 10,
Eniwumide JO, Lee DA, Bader DL(2005). Perfusion-Enhancement of molecular transport within 3D scaffolds. European Cells and Materials vol. 10, (SUPPL.2)
Heywood HK, Bader DL, Lee DA(2005). Superficial and deep chondrocyte subpopulations both express the crabtree effect but exhibit differences in oxygen consumption rate. European Cells and Materials vol. 10, (SUPPL.2)
Sharma A, Bomzon Z, Lee DA, Kimmel E, Bader DL, Knight MM (2005). Compression-induced reorganization of cytoplasmic networks in bovine chondrocytes using mitochondria as markers. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 86, A34-A34.
Screen HRC, Shelton JC, Bader DL, Lee DA (2005). Cyclic tensile strain upregulates collagen production in isolated tendon fascicles. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 86, A8-A9.
10.1016/j.bbrc.2005.08.102
Heywood HK, Bader DL, Lee DA (2005). Glucose metabolism of chondrocytes in tissue-engineered alginate constructs. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 86, A13-A14.
Appleby RN, Chowdhury TT, Salter DM, Bader DL, Lee DA (2005). Integrin-mediated mechanotransduction in IL-1 beta-stimulated chondrocytes. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 86, A38-A39.
Baria KE, Bader DL, Screen HRC, Lee DA (2005). The effect of substrate and medium composition on the response of human dermal fibroblasts to cyclic tensile strain in vitro. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 86, A32-A33.
Rugg EL, Al-Rawi H, Lee D, McNeill AM (2005). Trimethylamine N-oxide reduces the effects of osmotic stress in EBS keratinocytes. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 124, A76-A76.
Goldberg AJ, Lee DA, Bader DL, Bentley G(2005). Autologous chondrocyte implantation. Culture in a TGF-beta-containing medium enhances the re-expression of a chondrocytic phenotype in passaged human chondrocytes in pellet culture. J Bone Joint Surg Br vol. 87, (1) 128-134.
10.1302/0301-620X.87B1.14154
Sudre L, Cheung F, Kevorkian L, Young DA, Darrah C, Donell ST, Shepstone L, Porter S et al.(2005). British society for matrix biology autumn meeting. International Journal of Experimental Pathology vol. 86, (3)
10.1111/j.0959-9673.2005.00426.x
Wang Y-N, Bouten CVC, Lee DA, Bader DL(2005). Compression-induced damage in a muscle cell model in vitro. Proc Inst Mech Eng H vol. 219, (1) 1-12.
10.1243/095441105X9246
Screen HRC, Bader DL, Lee DA, Shelton JC(2004). Local strain measurement within tendon. STRAIN vol. 40, (4) 157-163.
10.1111/j.1475-1305.2004.00164.x
Heywood HK, Sembi PK, Lee DA, Bader DL(2004). Cellular utilization determines viability and matrix distribution profiles in chondrocyte-seeded alginate constructs. Tissue Eng vol. 10, (9-10) 1467-1479.
10.1089/ten.2004.10.1467
Bryant SJ, Anseth KS, Lee DA, Bader DL(2004). Crosslinking density influences the morphology of chondrocytes photoencapsulated in PEG hydrogels during the application of compressive strain. J Orthop Res vol. 22, (5) 1143-1149.
10.1016/j.orthres.2004.02.001
Chowdhury TT, Salter DM, Bader DL, Lee DA(2004). Integrin-mediated mechanotransduction processes in TGFbeta-stimulated monolayer-expanded chondrocytes. Biochem Biophys Res Commun vol. 318, (4) 873-881.
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