Publications:  Prof David Lee

Rice A, Cortes E, Lachowski D, Oertle P, Matellan C, Thorpe SD, Ghose R, Wang H et al.(2020). GPER activation inhibits cancer cell mechanotransduction and basement membrane invasion via RhoA. Cancers vol. 12, (2)

Thorpe S, Chronopoulos A, Cortes E, Lachowski D, Rice A, Mykuliak V, Róg T, Lee D et al.(2020). Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathway. Nature Materials

Cortes E, Sarper M, Robinson B, Lachowski D, Chronopoulos A, Thorpe SD, Lee DA, del Río Hernández AE(2019). GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment. EMBO Reports vol. 20, (1)

Cortes E, Lachowski D, Robinson B, Sarper M, Teppo JS, Thorpe SD, Lieberthal TJ, Iwamoto K et al.(2019). Tamoxifen mechanically reprograms the tumor microenvironment via HIF-1A and reduces cancer cell survival. EMBO Reports vol. 20, (1)

Cortes E, Lachowski D, Rice A, THORPE SD, Robinson B, Yeldag G, LEE DA, Ghemtio L et al.(2018). Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor. Oncogene

Cortes E, Lachowski D, Rice A, Chronopoulos A, Robinson B, THORPE SD, LEE DA, Possamai LA et al.(2018). RAR‐β is downregulated in HCC & cirrhosis and its expression inhibits myosin‐driven activation and durotaxis in hepatic stellate cells. Hepatology

Heywood HK, Thorpe SD, Jeropoulos RM, Lee DA (2017). Small molecule activators of SIRT1 augment the regenerative potential of chondrocytes for cell-based cartilage repair techniques. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 98, A14-A14.

Panesar KS, Thorpe SD, Lee DA (2017). Uniaxial tensile strain modulates mesenchymal stem cell nuclear structure and histone methylation in a differentiation dependent manner. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 98, A11-A12.

Elyasigomari V, Lee DA, Screen HRC, SHAHEED MH(2017). Development of a two-stage gene selection method that incorporates a novel hybrid approach using the cuckoo optimization algorithm and harmony search for cancer classification. Journal of Biomedical Informatics vol. 67, (2017) 11-20.

THORPE SD, Lee DA(2017). Dynamic regulation of nuclear architecture and mechanics—a rheostatic role for the nucleus in tailoring cellular mechanosensitivity. Nucleus vol. 8, (3) 287-300.

Eraifej J, Thorpe SD, Martins RP, Lee DA (2017). Does lamin A/C play a role in neuronal differentiation?. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 98, A12-A12.

Thorpe SD, Oti A, Mauck RL, Lee DA (2017). Stem cell differentiation state modulates Lamin AC localization and phosphorylation in response to cyclic tensile strain. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 98, A13-A14.

Heywood HK, Caton PW, Lee DA (2016). SIRT1, an enzyme vital to cartilage homeostasis, is regulated by osmolarity and glucose levels. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 97, A2-A2.

Heo S-J, Driscoll TP, Thorpe SD, Nerurkar NL, Baker BM, Yang MT, Chen CS, Lee DA et al.(2016). Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity. eLife vol. 5,

Tilwani RK, Vessillier S, Pingguan-Murphy B, Lee DA, Bader DL, Chowdhury TT(2016). Oxygen tension modulates the effects of TNFα in compressed chondrocytes. Inflamm Res

Heo SJ, Han WM, Szczesny SE, Cosgrove BD, Elliott DM, Lee DA, Duncan RL, Mauck RL(2016). Mechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells. Biophysical Journal vol. 111, (4) 864-874.

Heywood HK, Lee DA(2016). Bioenergetic reprogramming of articular chondrocytes by exposure to exogenous and endogenous reactive oxygen species and its role in the anabolic response to low oxygen. Journal of Tissue Engineering and Regenerative Medicine vol. 11, (8) 2286-2294.

Sliogeryte K, Botto L, Lee DA, Knight MM(2016). Chondrocyte dedifferentiation increases cell stiffness by strengthening membrane-actin adhesion. Osteoarthritis and Cartilage vol. 24, (5) 912-920.

Theocharidis G, Drymoussi Z, Kao AP, Barber AH, Lee DA, Braun KM, Connelly JT(2016). Type VI Collagen Regulates Dermal Matrix Assembly and Fibroblast Motility. J Invest Dermatol vol. 136, (1) 74-83.

Theocharidis G, Drymoussi Z, Kao AP, Barber AH, Lee DA, Braun KM, Connelly JT(2016). Type VI collagen regulates dermal matrix assembly and fibroblast motility. Journal of Investigative Dermatology vol. 136, (1) 74-83.

Heo SJ, Thorpe SD, Driscoll TP, Duncan RL, Lee DA, Mauck RL(2015). Biophysical regulation of chromatin architecture instills a mechanical memory in mesenchymal stem cells. Scientific Reports vol. 5,

Chen J, Bader DL, Lee DA, Knight MM(2015). FINITE ELEMENT ANALYSIS of MECHANICAL DEFORMATION of CHONDROCYTE to 2D SUBSTRATE and 3D SCAFFOLD. Journal of Mechanics in Medicine and Biology vol. 15, (5)

Tilwani RK, Lee DA, Pingguan-Murphy B, Abas WABW, Chowdhury TT (2014). Hypoxia amplified catabolic effects induced by TNF alpha in chondrocytes - response reduced with biomechanical signals. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 95, A33-A34.

Thorpe SD, Lee DA (2014). Mesenchymal stem cell nuclear architecture is differentially regulated by lineage commitment and mechanical stimulation. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 95, A33-A33.

Heywood HK, Lee DA (2014). Reactive oxygen species drive the transformation to an oxidative energy metabolism in cultured articular chondrocytes. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 95, A15-A16.

Irianto J, Lee DA, Knight MM(2014). Quantification of chromatin condensation level by image processing. Med Eng Phys vol. 36, (3) 412-417.

Heywood HK, Nalesso G, Lee DA, Dell'accio F(2014). Culture expansion in low-glucose conditions preserves chondrocyte differentiation and enhances their subsequent capacity to form cartilage tissue in three-dimensional culture. Biores Open Access vol. 3, (1) 9-18.

Sliogeryte K, Thorpe SD, Lee DA, Botto L, Knight MM(2014). Stem cell differentiation increases membrane-actin adhesion regulating cell blebability, migration and mechanics. Scientific Reports vol. 4,

Irianto J, Swift J, Martins RP, McPhail GD, Knight MM, Discher DE, Lee DA(2013). Osmotic challenge drives rapid and reversible chromatin condensation in chondrocytes. Biophys J vol. 104, (4) 759-769.

Pattappa G, Thorpe SD, Jegard NC, Heywood HK, de Bruijn JD, Lee DA(2013). Continuous and Uninterrupted Oxygen Tension Influences the Colony Formation and Oxidative Metabolism of Human Mesenchymal Stem Cells. TISSUE ENGINEERING PART C-METHODS vol. 19, (1)

Chen J, Irianto J, Inamdar S, Pravincumar P, Lee DA, Bader DL, Knight MM(2012). Cell mechanics, structure, and function are regulated by the stiffness of the three-dimensional microenvironment. Biophys J vol. 103, (6) 1188-1197.

Bonzani IC, Campbell JJ, Knight MM, Williams A, Lee DA, Bader DL, Stevens MM(2012). Dynamic compressive strain influences chondrogenic gene expression in human periosteal cells: a case study. J Mech Behav Biomed Mater vol. 11, 72-81.

Branford OA, Lee DA, Rolfe KJ, Grobbelaar AO(2012). The attachment of intrinsic and extrinsic, mobilized and immobilized adhesion cells to collagen and fibronectin. Journal of Hand Surgery: European Volume vol. 37, (6) 564-572.

Branford OA, Lee DA, Bader DL, Grobbelaar AO(2012). The mechanics of flexor tendon adhesions. Journal of Hand Surgery: European Volume vol. 37, (6) 555-563.

Maeda E, Ye S, Wang W, Bader DL, Knight MM, Lee DA(2012). Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading. Biomechanics and Modeling in Mechanobiology vol. 11, (3-4) 439-447.

Martins RP, Finan JD, Guilak F, Lee DA(2012). Mechanical regulation of nuclear structure and function. Annu Rev Biomed Eng vol. 14, 431-455.

Hosny NA, Lee DA, Knight MM(2012). Single photon counting fluorescence lifetime detection of pericellular oxygen concentrations. J Biomed Opt vol. 17, (1)

Pattappa G, Heywood HK, de Bruijn JD, Lee DA(2011). The metabolism of human mesenchymal stem cells during proliferation and differentiation. J Cell Physiol vol. 226, (10) 2562-2570.

Lewinsohn AD, Anssari-Benham A, Lee DA, Taylor PM, Chester AH, Yacoub MH, Screen HRC(2011). Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment. Proc Inst Mech Eng H vol. 225, (8) 821-830.

Lewinsohn AD, Anssari-Benham A, Lee DA, Taylor PM, Chester AH, Yacoub MH, Screen HRC(2011). Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment. P I MECH ENG H vol. 225, (H8) 821-830.

Martyn SV, Heywood HK, Rockett P, Paine MD, Wang MJ, Dobson PJ, Sheard SJ, Lee DA et al.(2011). Electrospray deposited fibronectin retains the ability to promote cell adhesion. Journal of Biomedical Materials Research - Part B Applied Biomaterials vol. 96 B, (1) 110-118.

Chen J, Bader DL, Lee DA, Knight MM (2011). Finite Element Modeling of Cell Deformation When Chondrocyte Seeded Agarose Is Subjected to Compression. 8TH INTERNATIONAL CONFERENCE ON CELL & STEM CELL ENGINEERING (ICCE). vol. 30, 17-20.

Maeda E, Ye S, Wang W, Bader DL, Knight MM, Lee DA(2011). Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading. Biomechanics and Modeling in Mechanobiology1-9.

Lee DA, Brand J, Salter D, Akanji O-O, Chowdhury TT(2011). Quantification of mRNA using real-time PCR and Western blot analysis of MAPK events in chondrocyte/agarose constructs. Methods Mol Biol vol. 695, 77-97.

Lee DA, Knight MM, Campbell JJ, Bader DL(2011). Stem cell mechanobiology. J Cell Biochem vol. 112, (1) 1-9.

Pattappa G, Heywood HK, de Bruijn JD, Lee DA(2010). The metabolism of human mesenchymal stem cells during proliferation and differentiation. J Cell Physiol

Maeda E, Fleischmann C, Mein CA, Shelton JC, Bader DL, Lee DA(2010). Functional analysis of tenocytes gene expression in tendon fascicles subjected to cyclic tensile strain. Connective Tissue Research vol. 51, (6) 434-444.

Heywood HK, Knight MM, Lee DA(2010). Both superficial and deep zone articular chondrocyte subpopulations exhibit the crabtree effect but have different basal oxygen consumption rates. Journal of Cellular Physiology vol. 223, (3) 630-639.

Hosny NA, Lee DA, Knight MM (2010). Extracellular oxygen concentration mapping with confocal multiphoton laser scanning microscope and TCSPC card. MULTIPHOTON MICROSCOPY IN THE BIOMEDICAL SCIENCES X. Editors: Periasamy, A, So, PTC, Konig, K, vol. 7569,

Heywood HK, Lee DA(2010). Low oxygen reduces the modulation to an oxidative phenotype in monolayer-expanded chondrocytes. J Cell Physiol vol. 222, (1) 248-253.

Maeda E, Shelton JC, Bader DL, Lee DA(2009). Effect of intermittent cyclic tensile strain on collagen synthesis by tenocytes in isolated fascicles. Journal of Biomechanical Science and Engineering vol. 4, (4) 510-517.

Pattappa G, Jegard NC, Lee DA, de Bruijn JD(2009). The effect of oxygen tension on the proliferation and differentiation of human mesenchymal stem cells. European Cells and Materials vol. 18, (SUPPL. 1)

Mcleod R, Pattappa G, Irianto J, Awan M, Knight MM, Lee DA (2009). Graded hydrogel constructs for cartilage tissue engineering. European Cells and Materials. vol. 18,

Campbell JJ, Maeda E, Ye SJ, Wang W, Lee DA(2009). Osteogenic differentiation of human mesenchymal stem cells within a perfused bioreactor system. European Cells and Materials vol. 18, (SUPPL. 2)

Pattappa G, Jegard NC, de Bruijn JD, Lee DA(2009). The influence of oxygen tension on the colony formation and proliferation of human mesenchymal stem cells. European Cells and Materials vol. 18, (SUPPL. 2)

Maeda E, Shelton JC, Bader DL, Lee DA(2009). Differential regulation of gene expression in isolated tendon fascicles exposed to cyclic tensile strain in vitro. Journal of Applied Physiology vol. 106, (2) 506-512.

Berry CC, Shelton JC, Lee DA(2009). Cell-generated forces influence the viability, metabolism and mechanical properties of fibroblast-seeded collagen gel constructs. J Tissue Eng Regen Med vol. 3, (1) 43-53.

Eniwumide JO, Lee DA, Bader DL(2009). The development of a bioreactor to perfuse radially-confined hydrogel constructs: design and characterization of mass transport properties. Biorheology vol. 46, (5) 417-437.

Heywood HK, Lee DA(2008). Monolayer expansion induces an oxidative metabolism and ROS in chondrocytes. Biochem Biophys Res Commun vol. 373, (2) 224-229.

Maeda E, Shelton JC, Bader DL, Lee DA(2008). Collagen synthesis by tenocytes in fascicles subjected to intermittent cyclic strain. European Cells and Materials vol. 16, (SUPPL. 3)

Chowdhury TT, Salter DM, Bader DL, Lee DA(2008). Signal transduction pathways involving p38 MAPK, JNK, NF kappa B and AP-1 influences the response of chondrocytes cultured in agarose constructs to IL-1 beta and dynamic compression. INFLAMM RES vol. 57, (7) 306-313.

Heywood HK, Lee DA(2008). The effect of oxygen supply on chondrocyte metabolic phenotype during monolayer culture. European Cells and Materials vol. 16, (SUPPL. 3)

Chowdhury TT, Arghandawi S, Brand J, Akanji OO, Bader DL, Salter DM, Lee DA(2008). Dynamic compression counteracts IL-1beta induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs. Arthritis Res Ther vol. 10, (2)

Chowdhury TT, Akanji OO, Salter DM, Bader DL, Lee DA(2008). Dynamic compression influences interleukin-1 beta-induced nitric oxide and prostaglandin E-2 release by articular chondrocytes via alterations in iNOS and COX-2 expression. BIORHEOLOGY vol. 45, (3-4) 257-274.

Campbell JJ, Bader DL, Lee DA(2008). Mechanical loading modulates intracellular calcium signaling in human mesenchymal stem cells. J APPL BIOMATER BIOM vol. 6, (1) 9-15.

Akanji OO, Lee DA, Bader DA (2008). The effects of direct current stimulation on isolated chondrocytes seeded in 3D agarose constructs. BIORHEOLOGY. vol. 45, 229-243.

Maeda E, Shelton JC, Bader DL, Lee DA(2007). Time dependence of cyclic tensile strain on collagen production in tendon fascicles. BIOCHEM BIOPH RES CO vol. 362, (2) 399-404.

Bonzani IC, Knight MM, Lee DA, Bader DL, Williams A, Stevens MM (2007). A model for studying the influence of mechanical loading on human periosteal stem cells. TISSUE ENGINEERING. vol. 13, 1636-1636.

Heywood HK, Lee DA (2007). Development of an immunoassay for determination of adsorbed fibronectin levels on bio-functionalised substrates. TISSUE ENGINEERING. vol. 13, 1669-1670.

Chowdhury TT, Akanji OO, Arghandawi, Salter DM, Bader DL, Lee DA (2007). Dynamic compression counteracts IL-1 beta b induced iNOS and COX-2 expression in chondrocytes cultured in agarose constructs. TISSUE ENGINEERING. vol. 13, 1677-1677.

Maeda E, Shelton JC, Bader DL, Lee DA (2007). Gene expressions in tendon fascicles subjected to cyclic tensile strain. TISSUE ENGINEERING. vol. 13, 1701-1701.

Campbell JJ, Bader DL, Lee DA (2007). Mechanical loading modulates calcium signalling within mesenchymal stem cells. TISSUE ENGINEERING. vol. 13, 1722-1723.

Pattappa G, De Bruijn JD, Lee DA (2007). Mesenchymal stem cells maintain a glycolytic metabolism under normoxic conditions. TISSUE ENGINEERING. vol. 13, 1725-1725.

Mcleod R, Pattappa G, Irianto J, Knight MM, Lee DA (2007). The development and characterisation of chondrocyte-seeded gradient hydrogel constructs for cartilage tissue engineering. TISSUE ENGINEERING. vol. 13, 1763-1763.

Heywood HK, Bader DL, Lee DA (2006). Glucose concentration and medium volume influence cell viability and glycosaminoglycan synthesis in chondrocyte-seeded alginate constructs. Tissue Eng. vol. 12, 3487-3496.

Screen HRC, Chhaya VH, Greenwald SE, Bader DL, Lee DA, Shelton JC(2006). The influence of swelling and matrix degradation on the microstructural integrity of tendon. Acta Biomater vol. 2, (5) 505-513.

Knight MM, Bomzon Z, Kimmel E, Sharma AM, Lee DA, Bader DL(2006). Chondrocyte deformation induces mitochondrial distortion and heterogeneous intracellular strain fields. BIOMECH MODEL MECHAN vol. 5, (2-3) 180-191.

Akanji OO, Bader DL, Lee DA(2006). Direct current influences Ca ²⁺ signalling in chondrocytes. European Cells and Materials vol. 11, (SUPPL.2)

Chowdhury TT, Appleby RN, Salter DM, Bader DA, Lee DA(2006). Integrin-mediated mechanotransduction in IL-1 beta stimulated chondrocytes. Biomech Model Mechanobiol vol. 5, (2-3) 192-201.

Enobakhare B, Bader DL, Lee DA(2006). Concentration and M/G ratio influence the physiochemical and mechanical properties of alginate constructs for tissue engineering. J Appl Biomater Biomech vol. 4, (2) 87-96.

Heywood HK, Bader DL, Lee DA(2006). Rate of oxygen consumption by isolated articular chondrocytes is sensitive to medium glucose concentration. Journal of Cellular Physiology vol. 206, (2) 402-410.

Chowdhury TT, Bader DL, Lee DA(2006). Anti-inflammatory effects of IL-4 and dynamic compression in IL-1beta stimulated chondrocytes. Biochem Biophys Res Commun vol. 339, (1) 241-247.

Chowdhury TT, Bader DL, Lee DA(2006). Dynamic compression counteracts IL-1beta induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs. Biorheology vol. 43, (3,4) 413-429.

Campbell JJ, Lee DA, Bader DL (2006). Dynamic compressive strain influences chondrogenic gene expression in human mesenchymal stem cells. BIORHEOLOGY. vol. 43, 455-470.

Knight MM, Toyoda T, Lee DA, Bader DL(2006). Mechanical compression and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose. J Biomech vol. 39, (8) 1547-1551.

Pingguan-Murphy B, Lee DA, Bader DL, Knight MM(2005). Activation of chondrocytes calcium signalling by dynamic compression is independent of number of cycles. Arch Biochem Biophys vol. 444, (1) 45-51.

Screen HRC, Bader DL, Shelton JC, Lee DA(2005). Cyclic mechanical conditioning of isolated tendon fascicles results in an upregulation of collagen production. Proceedings of the 2005 Summer Bioengineering Conference vol. 2005, 193-194.

Pingguan B, Lee DA, Bader DL, Knight MM (2005). Dynamic compression activates chondrocyte calcium signaling in a cycle dependent manner involving the release of ATP. Proceedings of the 2005 Summer Bioengineering Conference. vol. 2005, 223-224.

Chowdhury TT, Bader DL, Lee DA(2005). Dynamic compression counteracts IL-1-induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs. Proceedings of the 2005 Summer Bioengineering Conference vol. 2005, 251-252.

Wang MJ, Heywood HK, Bader DL, Paine MD, Stark JPW, Lee DA(2005). Identification and characterization of deposited fibronectin on biocompatible materials: Comparison of electrospray and wetting methods. Proceedings of the 2005 Summer Bioengineering Conference vol. 2005, 439-440.

Chowdhury TT, Appleby RN, Salter DA, Bader DL, Lee DA(2005). Integrin mediated mechanotransduction in IL-1 stimulated bovine chondrocytes cultured in agarose constructs. Proceedings of the 2005 Summer Bioengineering Conference vol. 2005, 545-546.

Bader DL, Lee DA(2005). Mechanical conditioning of cell-seeded constructs for soft tissue repair - Are optimisation strategies possible?. 165-192.

Screen HRC, Shelton JC, Bader DL, Lee DA(2005). Cyclic tensile strain upregulates collagen synthesis in isolated tendon fascicles. Biochem Biophys Res Commun vol. 336, (2) 424-429.

Sengers BG, Heywood HK, Lee DA, Oomens CWJ, Bader DL(2005). Nutrient utilization by bovine articular chondrocytes: a combined experimental and theoretical approach. J Biomech Eng vol. 127, (5) 758-766.

Screen HRC, Shelton JC, Chhaya VH, Kayser MV, Bader DL, Lee DA(2005). The influence of noncollagenous matrix components on the micromechanical environment of tendon fascicles. Ann Biomed Eng vol. 33, (8) 1090-1099.

Chowdhury TT, Bader DL, Lee DA(2005). Dynamic compression counteracts IL-1β induced INOS and COX-2 activity by human chondrocytes cultured in agarose constructs. European Cells and Materials vol. 10, (SUPPL.2)

Catuogno C, Chowdhury TT, Bader DL, Lee DA(2005). Dynamic compression influences the biochemical response of human mesenchymal stem cells cultured in agarose constructs. European Cells and Materials vol. 10, (SUPPL.2)

Pingguna B, Lee DA, Bader DL, Knight MM (2005). Mechanical compression activates chondrocyte Calcium signalling in a cycle dependent Manner Involving the release of ATP. European Cells and Materials. vol. 10,

Eniwumide JO, Lee DA, Bader DL(2005). Perfusion-Enhancement of molecular transport within 3D scaffolds. European Cells and Materials vol. 10, (SUPPL.2)

Heywood HK, Bader DL, Lee DA(2005). Superficial and deep chondrocyte subpopulations both express the crabtree effect but exhibit differences in oxygen consumption rate. European Cells and Materials vol. 10, (SUPPL.2)

Sharma A, Bomzon Z, Lee DA, Kimmel E, Bader DL, Knight MM (2005). Compression-induced reorganization of cytoplasmic networks in bovine chondrocytes using mitochondria as markers. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 86, A34-A34.

Screen HRC, Shelton JC, Bader DL, Lee DA (2005). Cyclic tensile strain upregulates collagen production in isolated tendon fascicles. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 86, A8-A9.

Heywood HK, Bader DL, Lee DA (2005). Glucose metabolism of chondrocytes in tissue-engineered alginate constructs. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 86, A13-A14.

Appleby RN, Chowdhury TT, Salter DM, Bader DL, Lee DA (2005). Integrin-mediated mechanotransduction in IL-1 beta-stimulated chondrocytes. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 86, A38-A39.

Baria KE, Bader DL, Screen HRC, Lee DA (2005). The effect of substrate and medium composition on the response of human dermal fibroblasts to cyclic tensile strain in vitro. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 86, A32-A33.

Rugg EL, Al-Rawi H, Lee D, McNeill AM (2005). Trimethylamine N-oxide reduces the effects of osmotic stress in EBS keratinocytes. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 124, A76-A76.

Goldberg AJ, Lee DA, Bader DL, Bentley G(2005). Autologous chondrocyte implantation. Culture in a TGF-beta-containing medium enhances the re-expression of a chondrocytic phenotype in passaged human chondrocytes in pellet culture. J Bone Joint Surg Br vol. 87, (1) 128-134.

Sudre L, Cheung F, Kevorkian L, Young DA, Darrah C, Donell ST, Shepstone L, Porter S et al.(2005). British society for matrix biology autumn meeting. International Journal of Experimental Pathology vol. 86, (3)

Wang Y-N, Bouten CVC, Lee DA, Bader DL(2005). Compression-induced damage in a muscle cell model in vitro. Proc Inst Mech Eng H vol. 219, (1) 1-12.

Screen HRC, Bader DL, Lee DA, Shelton JC(2004). Local strain measurement within tendon. STRAIN vol. 40, (4) 157-163.

Heywood HK, Sembi PK, Lee DA, Bader DL(2004). Cellular utilization determines viability and matrix distribution profiles in chondrocyte-seeded alginate constructs. Tissue Eng vol. 10, (9-10) 1467-1479.

Bryant SJ, Anseth KS, Lee DA, Bader DL(2004). Crosslinking density influences the morphology of chondrocytes photoencapsulated in PEG hydrogels during the application of compressive strain. J Orthop Res vol. 22, (5) 1143-1149.

Chowdhury TT, Salter DM, Bader DL, Lee DA(2004). Integrin-mediated mechanotransduction processes in TGFbeta-stimulated monolayer-expanded chondrocytes. Biochem Biophys Res Commun vol. 318, (4) 873-881.

Bryant SJ, Chowdhury TT, Lee DA, Bader DL, Anseth KS(2004). Crosslinking density influences chondrocyte metabolism in dynamically loaded photocrosslinked poly(ethylene glycol) hydrogels. Ann Biomed Eng vol. 32, (3) 407-417.

Screen HRC, Lee DA, Bader DL, Shelton JC(2004). An investigation into the effects of the hierarchical structure of tendon fascicles on micromechanical properties. Proc Inst Mech Eng H vol. 218, (2) 109-119.

Chowdhury TT, Bader DL, LEE DA (2004). Combined anti-inflammatory effects of IL-4 and dynamic compression in IL-1beta stimulated bovine chondrocytes cultured in agarose constructs. Trans. Orthop. Res. Soc.. Conference: 50th Annual Meeting of the Orthopaedic Research Society vol. 29, 144-144.

Knight MM, Hibbs K, Roberts SR, LEE DA, Bader DL (2004). Cyclic preconditioning mediates chondrocytes calcium signaling in unstrained and compressed agarose constructs. Trans. Orthop. Res. Soc.. Conference: 50th Annual Meeting of the Orthopaedic Research Society vol. 29, 829-829.

Chowdhury TT, Bader DL, Lee DA (2004). Dynamic compression counteracts IL-1 beta-induced iNOS and COX-2 activity in human chondrocytes cultured in agarose constructs. OSTEOARTHRITIS AND CARTILAGE. vol. 12, S19-S19.

LEE DA, van Osch G, Verhaar JAN, Mandl EW, van der Linden JC, van der Breevaart Bravenboer J, Weinans H(2004). Extracellular matrix influences the response of chondrocytes to dynamic compression. Trans. Orthop.Rev. Soc vol. 29, 839-839.

Heywood HK, Bader DL, Bongers M, LEE DA (2004). Glucose depletion induces an upregulation of oxygen utilisation by chondrocytes. Trans. Orthop. Res. Soc.. Conference: 50th Annual Meeting of the Orthopaedic Research Society vol. 29, 261-261.

Knight MM, Bonzom Z, Sharma AM, LEE DA, Kimmel E, Bader DL (2004). Heterogeneity of deformation of cytoplasmic networks in compressed chondrocytes. Trans. Orthops. Res. Soc.. Conference: 50th Annual Meeting of the Orthopaedic Research Society vol. 29, 544-544.

Bader DL, KNIGHT MM, Bentley G, Kayser M, Holloway I(2004). Increased presence of cells with multiple elongated processes in osteoarthritic femoral head cartilage. Osteoarthritis Cartilage vol. 12, (1) 17-24.

Holloway I, Kayser M, Lee DA, Bader DL, Bentley G, Knight MM(2004). Increased presence of cells with multiple elongated processes in osteoarthritic femoral head cartilage. Osteoarthritis Cartilage vol. 12, (1) 17-24.

Chowdhury TT, Appleby RN, Salter DM, Bader DL, Lee DA (2004). Integrin-mediated mechanotransduction in IL-1 beta stimulated chondrocytes. OSTEOARTHRITIS AND CARTILAGE. vol. 12, S102-S102.

Lee DA, Knight MM(2004). Mechanical loading of chondrocytes embedded in 3D constructs: in vitro methods for assessment of morphological and metabolic response to compressive strain. Methods Mol Med vol. 100, 307-324.

Heywood HK, DeRosa E, LEE DA, Bader DL, Netti P (2004). Non-invasive monitoring of molecular diffusion in neo-cartilage using FRAP technique. Trans. Orthop. Res. Soc.. Conference: 50th Annual Meeting of the Orthopaedic Research Society vol. 29, 531-531.

Wiseman M, Bader DL, Reisler T, Lee DA(2004). Passage in monolayer influences the response of chondrocytes to dynamic compression. Biorheology vol. 41, (3-4) 283-298.

Chowdhry TT, Salter DM, Bader DL, LEE DA (2004). alpha 5 beta 1 integrin mediates mechanotransduction processes in TGF-beta stimulated human chondrocytes seeded in agarose constructs and subjected to dynamic compression. Trans. Orthop. Res. Soc.. Conference: 50th Annual Meeting of the Orthopaedic Research Society vol. 29, 338-338.

Chowdhury TT, Bader DL, Lee DA(2003). Dynamic compression counteracts IL-1 beta-induced release of nitric oxide and PGE2 by superficial zone chondrocytes cultured in agarose constructs. Osteoarthritis Cartilage vol. 11, (9) 688-696.

Chowdhury TT, Bader DL, Shelton JC, Lee DA(2003). Temporal regulation of chondrocyte metabolism in agarose constructs subjected to dynamic compression. Arch Biochem Biophys vol. 417, (1) 105-111.

Berry CC, Shelton JC, Bader DL, Lee DA(2003). Influence of external uniaxial cyclic strain on oriented fibroblast-seeded collagen gels. Tissue Eng vol. 9, (4) 613-624.

Wiseman M, Henson F, Lee DA, Bader DL(2003). Dynamic compressive strain inhibits nitric oxide synthesis by equine chondrocytes isolated from different areas of the cartilage surface. Equine Vet J vol. 35, (5) 451-456.

Knight MM, Roberts SR, Lee DA, Bader DL (2003). Live cell imaging using confocal microscopy induces intracellular calcium transients and cell death. American Journal of Physiology - Cell Physiology. vol. 284,

Knight MM, Roberts SR, Lee DA, Bader DL(2003). Live cell imaging using confocal microscopy induces intracellular calcium transients and cell death. Am J Physiol Cell Physiol vol. 284, (4) C1083-C1089.

Lee DA, Reisler T, Bader DL(2003). Expansion of chondrocytes for tissue engineering in alginate beads enhances chondrocytic phenotype compared to conventional monolayer techniques. Acta Orthop Scand vol. 74, (1) 6-15.

Chowdhury TT, Shelton JC, Bader DL, LEE DA(2003). Control of mechanotrasduction processes in dynamically stimulated human and bovine chondrocytes cultured in agarose constructs. Internat. J. Artificial Organs vol. 26, (9) 858-858.

Berry CC, Cacou C, Lee DA, Bader DL, Shelton JC(2003). Dermal fibroblasts respond to mechanical conditioning in a strain profile dependent manner. Biorheology vol. 40, (1-3) 337-345.

Screen HRC, Lee DA, Bader DL, Shelton JC(2003). Development of a technique to determine strains in tendons using the cell nuclei. Biorheology vol. 40, (1-3) 361-368.

LEE DA, Heywood HK, Baaijens FPT, Oomens CWJ, Sengers BG(2003). Experimental and theoretical analysis of glucose dependent oxygen utilization by bovine articular chondrocytes. Internat. J. Artificial Organs vol. 26, 875-875.

Shelton JC, Bader DL, Lee DA(2003). Mechanical conditioning influences the metabolic response of cell-seeded constructs. Cells Tissues Organs vol. 175, (3) 140-150.

SCREEN HRC, Shelton JC, Bader DL, Lee DA (2003). The effects on non-collagenous matrix components on tendon fascicle micromechanics. Trans. Orthop. Res. Soc.. Conference: 49th Annual Meeting of the Orthopaedic Research Society vol. 28, 806-806.

Hernandez D, Addou S, Lee D, Orengo C, Shephard EA, Phillips IR(2003). Trimethylaminuria and a human FMO3 mutation database. HUM MUTAT vol. 22, (3) 209-213.

Chowdhury TT, LEE DA, Salter DM, Shelton JC, Bader DL(2003). alpha5beta1 integrin mediates mechanotransduction processes in TGFbeta-stimulated human chondrocyte / agarose constructs and subjected to dynamic compression. Osteoarthritis Cartilage vol. 11, (Suppl 1) S2-S3.

Chowdhury TT, LEE DA, Salter DM, Shelton JC, Bader DL (2003). alpha5beta1 integrin mediates mechanotransduction processes in TGFbeta3-stimulated human chondrocytes seeded in agarose constructs and subjected to dynamic compression. Tissue Engineering. Conference: ETES vol. 9, 792-792.

Knight MM, Roberts SR, Lee DA, Bader DL (2002). Light-induced calcium signalling in chondrocytes. European Cells and Materials. vol. 4, 7-8.

Knight MM, Toyoda T, Bader DL, Lee DA (2002). Mechanical strain and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose. Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products.

Lee DA(2002). The design of bioreactor systems for cartilage tissue engineering. Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products

Berry CC, Shelton JC, Bader DL, Lee DA(2002). The influence of uniaxial cyclic strain on orientated fibroblast seeded collagen gels. Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products

Lee DA, Chowdhury TT, Roberts SR, Knight MM, Bader DL (2002). An in vitro investigation of cartilage mechanotransduction. INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS. vol. 25, 617-618.

Knight MM, van de Breevaart Bravenboer J, Lee DA, van Osch GJVM, Weinans H, Bader DL(2002). Cell and nucleus deformation in compressed chondrocyte-alginate constructs: temporal changes and calculation of cell modulus. Biochim Biophys Acta vol. 1570, (1) 1-8.

Holloway I, Knight MM, LEE DA, Bader DL, Bentley G (2002). Changes in cell morphology and cytoskeletal organisation in osteoarthritic cartilage. Eur Cell Mater. Conference: ECM III Cartilage & Joint repair Tutorials, Basic Research & Clinical Methods (Davos, Switzerland) from: 01/07/2002 to: 03/07/2002, vol. 4 suppl 1, 52-53.

Holloway I, Knight MM, LEE DA, Bader DL, Bentley G (2002). Characterisation of cell morphology, cytoskeletal organization and apoptosis in human osteoarthritic cartilage. Trans. Orthop. Res. Soc. Conference: 48th Annual Meeting of the Orthopaedic Research Society vol. 27,

Bader DL, Ohashi T, Knight MM, Lee DA, Sato M (2002). Deformation properties of articular chondrocytes: a critique of three separate techniques. Biorheology. vol. 39, 69-78.

BADER DL, Shelton JC, Lee DA, Screen HRC(2002). Development of a technique to determine strains in tendons using the cell nuclei. Biorheology vol. 40, 361-368.

Knight MM, Roberts SR, LEE DA, Bader DL (2002). Light-induced calcium signalling in chondrocytes. Eur. Cells Materials. Conference: TCES 2002 Annual meeting of the UK Tissue and Cell Engineering Society (University of Glasgow, Scotland) from: 19/09/2002 to: 20/09/2002, vol. 4, 7-8.

Knight MM, Toyoda T, LEE DA, Bader DL (2002). Mechanical strain and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose. Trans. Orthop. Res. Soc.. Conference: 48th Annual Meeting of the Orthopaedic Research Society vol. 27, 35-35.

Heywood HK, LEE DA, Bader DL (2002). Monitoring neo-cartilage formation in cell seeded alginate constructs of clinically relevant dimensions. Eur. Cells Materials. Conference: TCES 2002 Annual meeting of the UK Tissue and Cell Engineering Society (Glasgow, Scotland) from: 19/09/2002 to: 20/09/2002, vol. 4 suppl 2, 1-2.

Bader DL, Shelton JC, Lee DA, SCREEN HRC(2002). Non-collagenous matrix components influence the micromechanical environment of tenocytes within tendon fascicles subjected to tensile strain. Eur. Cells Mat. vol. 4:S1, 41-42.

SCREEN HRC, Lee DA, Bader DL, Shelton JC (2002). The strain behaviour of tendon under tensile load, using cell nuclei as strain markers. Trans. Orthop. Res. Soc.. Conference: 48th Annual Meeting of the Orthopaedic Research Society vol. 27, 604-604.

Chowdhury TT, Bader DL, Lee DA(2001). Dynamic compression inhibits the synthesis of nitric oxide and PGE(2) by IL-1beta-stimulated chondrocytes cultured in agarose constructs. Biochem Biophys Res Commun vol. 285, (5) 1168-1174.

Knight MM, Ross JM, Sherwin AF, Lee DA, Bader DL, Poole CA(2001). Chondrocyte deformation within mechanically and enzymatically extracted chondrons compressed in agarose. Biochim Biophys Acta vol. 1526, (2) 141-146.

Knight MM, Idowu BD, Lee DA, Bader DL(2001). Temporal changes in cytoskeletal organisation within isolated chondrocytes quantified using a novel image analysis technique. Med Biol Eng Comput vol. 39, (3) 397-404.

Roberts SR, Knight MM, Lee DA, Bader DL(2001). Mechanical compression influences intracellular Ca2+ signaling in chondrocytes seeded in agarose constructs. J Appl Physiol (1985) vol. 90, (4) 1385-1391.

Bouten CV, Knight MM, Lee DA, Bade DL(2001). Compressive deformation and damage of muscle cell subpopulations in a model system. Ann Biomed Eng vol. 29, (2) 153-163.

Bader DL, KNIGHT MM, Lee DA, Bouten CV(2001). Compressive deformation and damage of muscle cell subpopulaltions in a model system. Ann. Biomed. Eng. vol. 29, (2) 153-163.

Chowdhury T, Bader DL, LEE DA (2001). Dynamic compression influences the synthesis of nitric oxide by IL-1beta stimulated chondrocyte sub-populations cultured in agarose constructs. Trans. Orthop. Res. Soc. Conference: 47th Annual Meeting, Orthopaedic Research Society (San Francisco, California) from: 25/02/2001 to: 28/02/2001, vol. 26, 604-604.

Lee DA(2001). Embryonic stem cells: scientific possibilities, ethical considerations, and regulation in the UK. INTERDISCIPL SCI REV vol. 26, (2) 112-124.

LEE DA, Idowu BD, Knight MM, Bader DL (2001). Mechanical compression influences cytoskeletal oragnisation within chondrocytes seeded in agarose constructs. Trans. Orthop. Res. Soc.. Conference: 47th Annual Meeting, Orthopaedic Research Society (San Francisco, California) from: 25/02/2001 to: 28/02/2001, vol. 26, 263-263.

Enobakhare B, Bader DL, LEE DA (2001). Physiochemical, biochemical and mechanical characterisation of chondrocyte-alginate constructs. Trans. Orthop. Res. Soc. Conference: 47th Annual Meeting, Orthopaedic Research Society (San Francisco, California) from: 25/02/2001 to: 28/02/2001, vol. 26, 638-638.

Knight MM, van de Breevaart Brevenboer J, van Osch G, Weinans H, LEE DA, Bader DL (2001). Temporal changes in cell and nucleus deformation in isolated chondrocytes compressed in alginate scaffolds. Trans. Orthop. Res. Soc.. Conference: 47th Annual Meeting, Orthopaedic Research Society (San Francisco, California) from: 25/02/2001 to: 28/02/2001, vol. 26, 611-611.

Berry CC, Cacou C, Shelton JC, Bader DL, Lee DA(2000). Biological response of cyclic strain on developed cell seeded collagen gel model. Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling

Knight MM, Van De Breevaart Bravenboer J, Bader DL, Lee DA (2000). Compression induced cell and nucleus deformation in chondrocyte-alginate constructs. Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling.

Chowdhury TT, Bader DL, Lee DA(2000). Dynamic compression inhibits the synthesis of nitric oxide by IL-1β stimulated chondrocytes cultured in agarose constructs. Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling

Roberts SR, Knight MM, Lee DA, Bader DL (2000). Intracellular - CA2+ signalling in compressed chondrocyte agarose constructs. Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling.

Enobakhare BO, Bader DL, Lee DA(2000). Physiochemical, biochemical and mechanical characterisation of chondrocyte-alginate constructs. Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling

Cacou C, Palmer D, Lee DA, Bader DL, Shelton JC(2000). A system for monitoring the response of uniaxial strain on cell seeded collagen gels. MED ENG PHYS vol. 22, (5) 327-333.

Idowu BD, Knight MM, Bader DL, Lee DA(2000). Confocal analysis of cytoskeletal organisation within isolated chondrocyte sub-populations cultured in agarose. Histochem J vol. 32, (3) 165-174.

Roberts SR, Knight MM, Lee DA, Bader DL (2000). Intracellular calcium signalling in compressed chondrocyte agarose constructs. J PHYSIOL-LONDON. vol. 523, 12P-12P.

Lee DA, Knight MM, Bolton JF, Idowu BD, Kayser MV, Bader DL(2000). Chondrocyte deformation within compressed agarose constructs at the cellular and sub-cellular levels. J Biomech vol. 33, (1) 81-95.

Lee DA, Noguchi T, Frean SP, Lees P, Bader DL(2000). The influence of mechanical loading on isolated chondrocytes seeded in agarose constructs. Biorheology vol. 37, (1-2) 149-161.

White AET, Bentley G, Stephens MD, Bader DL, Giddins GEB, Lee DA(1999). The effects of storage temperature on the composition, metabolism acid biomechanical properties of human articular cartilage. KNEE vol. 6, (3) 197-205.

Knight MM, Ghori SA, Lee DA, Bader DL(1998). Measurement of the deformation of isolated chondrocytes in agarose subjected to cyclic compression. Med Eng Phys vol. 20, (9) 684-688.

Lee DA, Noguchi T, Knight MM, O'Donnell L, Bentley G, Bader DL(1998). Response of chondrocyte subpopulations cultured within unloaded and loaded agarose. J Orthop Res vol. 16, (6) 726-733.

Knight MM, Lee DA, Bader DL(1998). The influence of elaborated pericellular matrix on the deformation of isolated articular chondrocytes cultured in agarose. Biochim Biophys Acta vol. 1405, (1-3) 67-77.

Lee DA, Frean SP, Lees P, Bader DL(1998). Dynamic mechanical compression influences nitric oxide production by articular chondrocytes seeded in agarose. BIOCHEM BIOPH RES CO vol. 251, (2) 580-585.

Lee DA, Assoku E, Doyle V(1998). A specific quantitative assay for collagen synthesis by cells seeded in collagen-based biomaterials using sirius red F3B precipitation. J MATER SCI-MATER M vol. 9, (1) 47-51.

Lee DA, Bader DL(1997). Compressive strains at physiological frequencies influence the metabolism of chondrocytes seeded in agarose. J ORTHOP RES vol. 15, (2) 181-188.

Enobakhare BO, Bader DL, Lee DA(1996). Quantification of sulfated glycosaminoglycans in chondrocyte/alginate cultures, by use of 1,9-dimethylmethylene blue. ANAL BIOCHEM vol. 243, (1) 189-191.

Lee DA, Bader DL(1995). The development and characterization of an in vitro system to study strain-induced cell deformation in isolated chondrocytes. IN VITRO CELL DEV-AN vol. 31, (11) 828-835.