Publications: Prof Irene Leigh

Thomson J, Bewicke-Copley F, Anene CA, Gulati A, Nagano A, Purdie K, Inman GJ, Proby CM et al. ( 2021 ) . The Genomic Landscape of Actinic Keratosis . Journal of Investigative Dermatology vol. 141 , ( 7 ) 1664 - 1674.e7 .

Mannella V, Boehm K, Celik S, Ali T, Mirza AN, Hasnaouy ME, Kaffa A, Lyu Y et al. ( 2021 ) . Growth and viability of cutaneous squamous cell carcinoma cell lines display different sensitivities to isoform-specific phosphoinositide 3-kinase inhibitors . International Journal of Molecular Sciences vol. 22 , ( 7 )

McHugh A, Fernandes K, Chinner N, Ibrahim AFM, Garg AK, Boag G, Hepburn LA, Proby CM et al. ( 2020 ) . The Identification of Potential Therapeutic Targets for Cutaneous Squamous Cell Carcinoma . Journal of Investigative Dermatology vol. 140 , ( 6 ) 1154 - 1165.e5 .

Venables ZC, Nijsten T, Wong KF, Autier P, Broggio J, Deas A, Harwood CA, Hollestein LM et al. ( 2019 ) . Epidemiology of basal and cutaneous squamous cell carcinoma in the U.K. 2013–15: a cohort study . British Journal of Dermatology vol. 181 , ( 3 ) 474 - 482 .

Hassan S, Purdie KJ, Wang J, Harwood CA, Proby CM, Pourreyron C, Mladkova N, Nagano A et al. ( 2019 ) . A unique panel of patient-derived cutaneous squamous cell carcinoma cell lines provides a preclinical pathway for therapeutic testing . International Journal of Molecular Sciences vol. 20 , ( 14 )

Leigh IM, Proby CM, Inman GJ, Harwood CA ( 2019 ) . Azathioprine: friend or foe? . British Journal of Dermatology vol. 180 , ( 5 ) 961 - 963 .

Bottomley MJ, Thomson J, Harwood C, Leigh I ( 2019 ) . The role of the immune system in cutaneous squamous cell carcinoma . International Journal of Molecular Sciences vol. 20 , ( 8 )

Kalin JH, Eroglu A, Liu H, Holtzclaw WD, Leigh I, Proby CM, Fahey JW, Cole PA et al. ( 2019 ) . Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model . PLOS ONE vol. 14 , ( 3 ) e0213095 - e0213095 .

Inman GJ, Wang J, Nagano A, Alexandrov LB, Purdie KJ, Taylor RG, Sherwood V, Thomson J et al. ( 2018 ) . The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature . Nature Communications vol. 9 , ( 1 )

LEIGH IM, VENABLES Z, Autier P, Nijsten T, Wong K, Langan S, Rous B, Broggio J et al. ( 2018 ) . Nationwide Incidence of Metastatic Cutaneous Squamous Cell Carcinoma in England . JAMA Dermatology

Purdie KJ, Proby CM, Rizvi H, Griffin H, Doorbar J, Sommerlad M, Feltkamp MC, der Meijden EV et al. ( 2018 ) . The Role of Human Papillomaviruses and Polyomaviruses in BRAF-Inhibitor Induced Cutaneous Squamous Cell Carcinoma and Benign Squamoproliferative Lesions . Frontiers in Microbiology vol. 9 , 1806 - 1806 .

Hepburn LA, McHugh A, Fernandes K, Boag G, Proby CM, Leigh IM, Saville MK ( 2018 ) . Targeting the spliceosome for cutaneous squamous cell carcinoma therapy: a role for c-MYC and wild-type p53 in determining the degree of tumour selectivity . Oncotarget vol. 9 , ( 33 ) 23029 - 23046 .

McHugh A, Fernandes K, South AP, Mellerio JE, Salas-Alanís JC, Proby CM, Leigh IM, Saville MK ( 2018 ) . Preclinical comparison of proteasome and ubiquitin E1 enzyme inhibitors in cutaneous squamous cell carcinoma: the identification of mechanisms of differential sensitivity . Oncotarget vol. 9 , ( 29 ) 20265 - 20281 .

Rose AM, Spender LC, Stephen C, Mitchell A, Rickaby W, Bray S, Evans AT, Dayal J et al. ( 2018 ) . Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma . Oncotarget vol. 9 , ( 18 ) 14552 - 14566 .

Lai K, Harwood CA, Purdie KJ, Proby CM, Leigh IM, Ravi N, Mully TW, Brooks L et al. ( 2017 ) . Genomic analysis of atypical fibroxanthoma . PLoS One vol. 12 , ( 11 ) e0188272 - e0188272 .

Maruthappu T, Chikh A, Fell B, Delaney PJ, Brooke MA, Levet C, Moncada-Pazos A, Ishida-Yamamoto A et al. ( 2017 ) . Rhomboid family member 2 Regulates cytoskeletal stress associated Keratin 16 . Nature Communications vol. 8 , 14174 - 14174 .

Cammareri P, Rose AM, Vincent DF, Wang J, Nagano A, Libertini S, Ridgway RA, Athineos D et al. ( 2016 ) . Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma . Nature Communications vol. 7 , 12493 - 12493 .

Watt SA, Purdie KJ, den Breems NY, Dimon M, Tucker S, Arron ST, McHugh A, Xue DJ et al. ( 2016 ) . CREBBP mutation in human cutaneous squamous cell carcinoma . Experimental Dermatology vol. 25 , ( 8 ) 650 - 651 .

Harwood CA, Proby CM, Inman GJ, Leigh IM ( 2016 ) . The promise of genomics and the development of targeted therapies for cutaneous squamous cell carcinoma . Acta Dermato-Venereologica vol. 96 , ( 1 )

Watt SA, Purdie KJ, Den Breems NY, Dimon M, Arron ST, McHugh AT, Xue DJ, Dayal JHS et al. ( 2015 ) . Novel CARD11 Mutations in Human Cutaneous Squamous Cell Carcinoma Lead to Aberrant NF-κB Regulation . American Journal of Pathology vol. 185 , ( 9 ) 2354 - 2363 .

Cammareri P, Rose AM, Vincent DF, Libertini S, Ridgway RA, Athineos D, Coates P, McHugh A et al. ( 2015 ) . Abstract 1506: Frequent loss of function mutations in TGFβR1 and TGFβR2 identify hair follicle bulge stem cells as the cell of origin for cutaneous squamous cell carcinoma . Conference: Tumor Biology1506 - 1506 .

South AP, Purdie KJ, Watt SA, Haldenby S, den Breems N, Dimon M, Arron ST, Kluk MJ et al. ( 2014 ) . NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis . J Invest Dermatol vol. 134 , ( 10 ) 2630 - 2638 .

Lambert SR, Mladkova N, Gulati A, Hamoudi R, Purdie K, Cerio R, Leigh I, Proby C et al. ( 2013 ) . Key differences identified between actinic keratosis and cutaneous squamous cell carcinoma by transcriptome profiling . Br J Cancer vol. 110 , ( 2 ) 520 - 529 .

Blaydon DC, Lind LK, Plagnol V, Linton KJ, Smith FJD, Wilson NJ, McLean WHI, Munro CS et al. ( 2013 ) . Mutations in AQP5, encoding a water-channel protein, cause autosomal-dominant diffuse nonepidermolytic palmoplantar keratoderma . American Journal of Human Genetics vol. 93 , ( 2 ) 330 - 335 .

Matin RN, Chikh A, Chong SLP, Mesher D, Graf M, Sanza P, Senatore V, Scatolini M et al. ( 2013 ) . p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis . Journal of Experimental Medicine vol. 210 , ( 3 ) 581 - 603 .

Matin RN, Chikh A, Pak Chong SL, Mesher D, Graf M, Sanza P, Senatore V, Scatolini M et al. ( 2013 ) . p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis . Journal of Cell Biology . vol. 200 , i11 - i11 .

Harwood CA, Mesher D, McGregor JM, Mitchell L, Leedham-Green M, Raftery M, Cerio R, Leigh IM et al. ( 2013 ) . A surveillance model for skin cancer in organ transplant recipients: A 22-year prospective study in an ethnically diverse population . American Journal of Transplantation vol. 13 , ( 1 ) 119 - 129 .

Nigro CL, Wang H, McHugh A, Lattanzio L, Matin R, Harwood C, Syed N, Hatzimichael E et al. ( 2013 ) . Methylated tissue factor pathway inhibitor 2 (TFPI2) DNA in serum is a biomarker of metastatic melanoma . Journal of Investigative Dermatology vol. 133 , ( 5 ) 1278 - 1285 .

Lambert SR, Harwood CA, Purdie KJ, Gulati A, Matin RN, Romanowska M, Cerio R, Kelsell DP et al. ( 2012 ) . Metastatic cutaneous squamous cell carcinoma shows frequent deletion in the protein tyrosine phosphatase receptor Type D gene . International Journal of Cancer vol. 131 , ( 3 )

Bose A, Teh MT, Hutchison IL, Wan H, Leigh IM, Waseem A ( 2012 ) . Two mechanisms regulate keratin K15 expression in keratinocytes: Role of PKC/AP-1 and FOXM1 mediated signalling . PLoS ONE vol. 7 , ( 6 )

Wang H, Lee S, Lo Nigro C, Lattanzio L, Merlano M, Monteverde M, Matin R, Purdie K et al. ( 2012 ) . NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity . British Journal of Cancer vol. 106 , ( 8 ) 1446 - 1452 .

Blaydon DC, Etheridge SL, Risk JM, Hennies HC, Gay LJ, Carroll R, Plagnol V, McRonald FE et al. ( 2012 ) . RHBDF2 mutations are associated with tylosis, a familial esophageal cancer syndrome . American Journal of Human Genetics vol. 90 , ( 2 ) 340 - 346 .

Ismail F, Ikram M, Purdie K, Harwood C, Leigh I, Storey A ( 2011 ) . Cutaneous squamous cell carcinoma (scc) and the DNA damage response: Patm expression patterns in Pre-Malignant and malignant keratinocyte skin lesions . PLoS ONE vol. 6 , ( 7 )

Watt SA, Pourreyron C, Purdie K, Hogan C, Cole CL, Foster N, Pratt N, Bourdon J-C et al. ( 2011 ) . Integrative mRNA profiling comparing cultured primary cells with clinical samples reveals PLK1 and C20orf20 as therapeutic targets in cutaneous squamous cell carcinoma . Oncogene vol. 30 , ( 46 ) 4666 - 4677 .

Lambert SR, Harwood CA, Purdie KJ, Gulati A, Matin RN, Romanowska M, Cerio R, Kelsell DP et al. ( 2011 ) . Metastatic cutaneous squamous cell carcinoma shows frequent deletion in the protein tyrosine phosphatase receptor Type D gene . International Journal of Cancer vol. 7 , ( 6 )

Oji V, Tadini G, Akiyama M, Blanchet Bardon C, Bodemer C, Bourrat E, Coudiere P, Digiovanna JJ et al. ( 2010 ) . Revised nomenclature and classification of inherited ichthyoses: Results of the First Ichthyosis Consensus Conference in Sorze 2009 . Journal of the American Academy of Dermatology vol. 63 , ( 4 ) 607 - 641 .

Purdie KJ, Harwood CA, Gibbon K, Chaplin T, Young BD, Cazier JB, Singh N, Leigh IM et al. ( 2010 ) . High-resolution genomic profiling of human papillomavirus-associated vulval neoplasia . Br J Cancer vol. 102 , ( 6 ) 1044 - 1051 .

Purdie KJ, Pourreyron C, Fassihi H, Cepeda-Valdes R, Frew JW, Volz A, Weissenborn SJ, Pfister H et al. ( 2010 ) . No evidence that human papillomavirus is responsible for the aggressive nature of recessive dystrophic epidermolysis bullosa-associated squamous cell carcinoma . Journal of Investigative Dermatology vol. 130 , ( 12 ) 2853 - 2855 .

Gibbon KL, Ekeowa-Anderson AL, Leigh IM ( 2009 ) . External anogenital premalignant and malignant disease .

Purdie KJ, Harwood CA, Gulati A, Chaplin T, Lambert SR, Cerio R, Kelly GP, Cazier J-B et al. ( 2009 ) . Single nucleotide polymorphism array analysis defines a specific genetic fingerprint for well-differentiated cutaneous SCCs . J Invest Dermatol vol. 129 , ( 6 ) 1562 - 1568 .

Wong T, Gammon L, Liu L, Mellerio JE, Dopping-Hepenstal PJC, Pacy J, Elia G, Jeffery R et al. ( 2008 ) . Potential of fibroblast cell therapy for recessive dystrophic epidermolysis bullosa . J INVEST DERMATOL vol. 128 , ( 9 ) 2179 - 2189 .

Damodaran G, Syed M, Leigh I, Myers S, Navsaria H ( 2008 ) . Clinical application of skin substitutes . Expert Review of Dermatology vol. 3 , ( 3 ) 345 - 356 .

Lalli A, Tilakaratne WM, Ariyawardana A, Fitchett C, Leigh IM, Hagi-Pavli E, Cruchley AT, Parkinson EK et al. ( 2008 ) . An altered keratinocyte phenotype in oral submucous fibrosis: correlation of keratin K17 expression with disease severity . J ORAL PATHOL MED vol. 37 , ( 4 ) 211 - 220 .

Wong T, Gammon L, Liu L, Ozoemena L, Dopping-Hepenstal PJC, Jones C, Leigh IM, McGrath JA et al. ( 2007 ) . Intradermal injection of allogeneic normal human fibroblasts promotes type VII collagen deposition at the dermal-epidermal junction in individuals with recessive dystrophic epidermolysis bullosa . WOUND REPAIR REGEN vol. 15 , ( 6 ) A114 - A114 .

Pourreyron C, Cox G, Mao X, Volz A, Baksh N, Wong T, Fassihi H, Arita K et al. ( 2007 ) . Patients with recessive dystrophic epidermolysis bullosa develop squamous-cell carcinoma regardless of type VII collagen expression . J Invest Dermatol vol. 127 , ( 10 ) 2438 - 2444 .

Kelsell DP, HARWOOD CA, Leigh IM, Proby CM, Purdie KJ, Teh MT, Lambert SR, Young BD et al. ( 2007 ) . Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis . Genes Chromosomes Cancer vol. 46 , 661 - 669 .

Purdie KJ, Lambert SR, Teh M-T, Chaplin T, Molloy G, Raghavan M, Kelsell DP, Leigh IM et al. ( 2007 ) . Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis . Genes Chromosomes Cancer vol. 46 , ( 7 ) 661 - 669 .

Cox GA, Pourreyron C, Volz A, O'Toole EA, Chen M, Bruckner-Tuderman L, Salas-Alanis JC, Leigh IM et al. ( 2007 ) . Does the presence or absence of type VII collagen expression in individuals with recessive dystrophic epidermolysis bullosa have implications for the risk of developing squamous cell carcinoma? . BRITISH JOURNAL OF DERMATOLOGY . vol. 157 , 12 - 13 .

Purdie K, Lambert S, Teh M, Chaplin T, Molloy G, Raghavan M, Kelsell DP, Leigh IM et al. ( 2007 ) . Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis . BRITISH JOURNAL OF DERMATOLOGY . vol. 156 , 1100 - 1101 .

Mao X, Pourreyron C, Purdie K, Holder MV, Baksh N, Wong T, Fassihi H, Volz A et al. ( 2007 ) . Identification of the molecular signatures in cutaneous squamous cell carcinoma excised from patients with recessive dystrophic epidermolysis bullosa by using integrated genomic techniques . BRITISH JOURNAL OF DERMATOLOGY . vol. 156 , 1110 - 1110 .

Wong T, Gammon L, Liu L, Ozoemena L, Dopping-Hepenstal PJC, Jones C, Leigh IM, Navsaria H et al. ( 2007 ) . Intradermal injection of allogeneic normal human broblasts promotes type VII collagen deposition at the dermal-epidermal junction in individuals with recessive dystrophic epidermolysis bullosa . BRITISH JOURNAL OF DERMATOLOGY . vol. 156 , 1096 - 1096 .

Ekeowa-Anderson AL, Harwood CA, Perrett CM, Sahota A, Annan H, Ran H, Leigh IM, Gibbon KL ( 2007 ) . Vulval intraepithelial neoplasia and periungual Bowen's disease concordant for mucosal (HPV-34) and epidermodysplasia verruciformis (HPV-21) human papillomavirus types . CLIN EXP DERMATOL vol. 32 , ( 3 ) 304 - 307 .

Teh MT, Blaydon D, Ghali LR, Briggs V, Edmunds S, Pantazi E, Barnes MR, Leigh IM et al. ( 2007 ) . Erratum: Role for WNT16B in human epidermal keratinocyte proliferation and differentiation (Journal of Cell Science vol. 120 (330-339)) . Journal of Cell Science vol. 120 , ( 5 )

Teh MT, Blaydon D, Ghali LR, Briggs V, Edmunds S, Pantazi E, Barnes MR, Leigh IM et al. ( 2007 ) . Role for WNT16B in human epidermal keratinocyte proliferation and differentiation (vol 120, pg 330, 2007) . J CELL SCI vol. 120 , ( 5 ) 917 - 917 .

Perrett CM, McGregor JM, Warwick J, Karran P, Leigh IM, Proby CM, Harwood CA ( 2007 ) . Treatment of post-transplant premalignant skin disease: a randomized intrapatient comparative study of 5-fluorouracil cream and topical photodynamic therapy . Br J Dermatol vol. 156 , ( 2 ) 320 - 328 .

Teh M-T, Blaydon D, Ghali LR, Briggs V, Edmunds S, Pantazi E, Barnes MR, Leigh IM et al. ( 2007 ) . Role for WNT16B in human epidermal keratinocyte proliferation and differentiation . J Cell Sci vol. 120 , ( Pt 2 ) 330 - 339 .

Myers SR, Leigh IM, Navsaria H ( 2007 ) . Epidermal repair results from activation of follicular and epidermal progenitor keratinocytes mediated by a growth factor cascade . Wound Repair Regen vol. 15 , ( 5 ) 693 - 701 .

McMillan JR, Akiyama M, Rouan F, Mellerio JE, Lane EB, Leigh IM, Owaribe K, Wiche G et al. ( 2007 ) . Plectin defects in epidermolysis bullosa simplex with muscular dystrophy . MUSCLE NERVE vol. 35 , ( 1 ) 24 - 35 .

Price RD, Das-Gupta V, Leigh IM, Navsaria HA ( 2006 ) . A comparison of tissue-engineered hyaluronic acid dermal matrices in a human wound model . Tissue Eng vol. 12 , ( 10 ) 2985 - 2995 .

Price RD, Das-Gupta V, Leigh IM, Navsaria HA ( 2006 ) . A Comparison of Tissue-Engineered Hyaluronic Acid Dermal Matrices in a Human Wound Model . Tissue Engineering vol. 0 , ( 0 )

Purdie K, Lambert S, Harwood C, Teh T, Kelsell D, Young B, Leigh I, Proby C ( 2006 ) . Allelic imbalances and chromosome 9p microdeletion demonstrated in cutaneous squamous cell carcinomas using single nucleotide polymorphism microarray analysis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 126 , 87 - 87 .

Sinclair C, O'Toole E, Leigh I, Paige D, Elbashir H, Stevens H, Booy R, Mein C et al. ( 2006 ) . Filaggrin mutation is not a genetic risk factor for atopic dermatitis in the Bangladeshi population . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 126 , 40 - 40 .

Wong T, Gammon L, Liu L, Ozoemena L, Dopping-Hepenstal PJ, Jones C, Leigh IM, Navsaria H et al. ( 2006 ) . Intradermal injection of allogeneic human fibroblasts promotes type VII collagen deposition at the dermal-epidermal junction in recessive dystrophic epidermolysis bullosa . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 126 , 32 - 32 .

Pourreyron C, Jones C, Volz A, O'Toole EA, Chen M, Hart IR, Bruckner-Tuderman L, Salis-Alanis JC et al. ( 2006 ) . Patients with recessive dystrophic epidermolysis bullosa develop squamous cell carcinoma regardless of type VII collagen NC1 domain expression . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 126 , 32 - 32 .

Norgett EE, Lucke TW, Bowers B, Munro CS, Leigh IM, Kelsell DP ( 2006 ) . Early death from cardiomyopathy in a family with autosomal dominant striate palmoplantar keratoderma and woolly hair associated with a novel insertion mutation in desmoplakin . J Invest Dermatol vol. 126 , ( 7 ) 1651 - 1654 .

Mak RKH, Paige D, Leigh IM, Kelsell DP, O’toole EA ( 2006 ) . Two siblings with harlequin ichthyosis, clinical and molecular findings . Annales de Dermatologie et de Vénéréologie vol. 133 , ( 6-7 )

Green J, Ikram M, Vyas J, Patel N, Proby CM, Ghali L, Leigh IM, O'Toole EA et al. ( 2006 ) . Overexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumours . Br J Cancer vol. 94 , ( 10 ) 1446 - 1451 .

Purdie K, Teh M, Harwood C, Young B, Proby C, Leigh I ( 2006 ) . Allelic imbalances and chromosome 9p microdeletion demonstrated in cutaneous squamous cell carcinomas using single nucleotide polymorphism microarray analysis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 126 , 18 - 18 .

Harwood CA, Proby CM, McGregor JM, Sheaff MT, Leigh IM, Cerio R ( 2006 ) . Clinicopathologic features of skin cancer in organ transplant recipients: a retrospective case-control series . J Am Acad Dermatol vol. 54 , ( 2 ) 290 - 300 .

Uzumcu A, Norgett EE, Dindar A, Uyguner O, Nisli K, Kayserili H, Sahin SE, Dupont E et al. ( 2006 ) . Loss of desmoplakin isoform I causes early onset cardiomyopathy and heart failure in a Naxos-like syndrome . J Med Genet vol. 43 , ( 2 )

Common JEA, O'Toole EA, Leigh IM, Thomas A, Griffiths WAD, Venning V, Grabczynska S, Peris Z et al. ( 2005 ) . Clinical and genetic heterogeneity of erythrokeratoderma variabilis . J Invest Dermatol vol. 125 , ( 5 ) 920 - 927 .

Leigh IM ( 2005 ) . Genetic diseases affecting the epidermis . Exp Dermatol vol. 14 , ( 10 ) 792 - 793 .

Alam NA, Olpin S, Rowan A, Kelsell D, Leigh IM, Tomlinson IPM, Weaver T ( 2005 ) . Missense mutations in fumarate hydratase in multiple cutaneous and uterine leiomyomatosis and renal cell cancer . J Mol Diagn vol. 7 , ( 4 ) 437 - 443 .

Kelsell DP, Norgett EE, Unsworth H, Teh MT, Cullup T, Mein CA, Dopping-Hepenstal PJ, Kennedy CT et al. ( 2005 ) . Clinical and molecular features of Harlequin ichthyosis . BRITISH JOURNAL OF DERMATOLOGY . vol. 153 , 5 - 5 .

Giehl KA, Dean D, Dawber RPR, Leigh I, de Berker DAR, Wojnarowska F ( 2005 ) . Cytokeratin expression in pili annulati hair follicles . CLIN EXP DERMATOL vol. 30 , ( 4 ) 426 - 428 .

Alam NA, Olpin S, Leigh IM ( 2005 ) . Fumarate hydratase mutations and predisposition to cutaneous leiomyomas, uterine leiomyomas and renal cancer . BRIT J DERMATOL vol. 153 , ( 1 ) 11 - 17 .

Harwood CA, Ismail F, Leedham-Green M, Leigh IM, Proby CM ( 2005 ) . Low-dose retinoids in the prevention of cutaneous squamous cell carcinomas in organ-transplant recipients: a 16-year retrospective study . BRITISH JOURNAL OF DERMATOLOGY . vol. 153 , 3 - 4 .

Kelsell DP, Norgett EE, Unsworth H, Teh M-T, Cullup T, Mein CA, Dopping-Hepenstal PJ, Dale BA et al. ( 2005 ) . Mutations in ABCA12 underlie the severe congenital skin disease harlequin ichthyosis . Am J Hum Genet vol. 76 , ( 5 ) 794 - 803 .

Fitchett CJ, Rugg EL, Gilfillan N, Leigh IM, O'Toole EA ( 2005 ) . Functional effects of pachyonychia congenita type I mutations on keratinocyte migration and proliferation . BRITISH JOURNAL OF DERMATOLOGY . vol. 152 , 835 - 835 .

Fitchett CJ, Rugg EL, Gilfillan N, Leigh IM, O'Toole EA ( 2005 ) . Functional effects of pachyonychia congenital type I mutations on keratinocyte motility and proliferation . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 124 , A95 - A95 .

Purdie K, Surentheran T, Sterling J, Bell L, McGregor J, Proby C, Harwood C, Leigh I et al. ( 2005 ) . Human papillomavirus gene expression in cutaneous squamous cell carcinomas from immunosuppressed and immunocompetent individuals . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 124 , A125 - A125 .

Harwood CA, Leedham-Green M, Leigh IM, Proby CM ( 2005 ) . Low-dose retinoids in the prevention of cutaneous squamous cell carcinomas in organ transplant recipients: a 16-year retrospective study . Arch Dermatol vol. 141 , ( 4 ) 456 - 464 .

Alam NA, Olpin S, Rowan A, Kelsell D, Leigh IM, Tomlinson IPM, Weaver T ( 2005 ) . Missense FH mutations in multiple cutaneous and uterine leiomyomatosis and renal cell cancer . BRITISH JOURNAL OF DERMATOLOGY . vol. 152 , 845 - 845 .

Kelsell DP, Norgett E, Unsworth H, Teh M, Cullop T, Dale B, Leigh IM, Eady RA et al. ( 2005 ) . Mutations in ABCA12 underlie harlequin ichthyosis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 124 , A75 - A75 .

Alam NA, Barclay E, Rowan AJ, Tyrer JP, Calonje E, Manek S, Kelsell D, Leigh I et al. ( 2005 ) . Clinical features of multiple cutaneous and uterine leiomyomatosis: an underdiagnosed tumor syndrome . Arch Dermatol vol. 141 , ( 2 ) 199 - 206 .

Harwood CA, Perrett CM, Brown VL, Leigh IM, McGregor JM, Proby CM ( 2005 ) . Imiquimod cream 5% for recalcitrant cutaneous warts in immunosuppressed individuals . Br J Dermatol vol. 152 , ( 1 ) 122 - 129 .

Price RD, Myers S, Leigh IM, Navsaria HA ( 2005 ) . The role of hyaluronic acid in wound healing: assessment of clinical evidence . Am J Clin Dermatol vol. 6 , ( 6 ) 393 - 402 .

Rugg EL, Leigh IM ( 2004 ) . The keratins and their disorders . AM J MED GENET C vol. 131C , ( 1 ) 4 - 11 .

Gaspar HB, Harwood C, Leigh I, Thrasher AJ ( 2004 ) . Severe cutaneous papillomavirus disease after haematopoietic stem-cell transplantation in patients with severe combined immunodeficiency . BRIT J HAEMATOL vol. 127 , ( 2 ) 232 - 233 .

Norgett EE, Wolf F, Balme B, Leigh IM, Perrot H, Kelsell DP, Haftek M ( 2004 ) . Hereditary 'white nails': a genetic and structural study . Br J Dermatol vol. 151 , ( 1 ) 65 - 72 .

Hubbard VG, Breuer J, Leigh IM, Thrasher A, Harwood CA ( 2004 ) . Viral warts following bone marrow transplantation for severe combined immunodeficiency harbour potentially oncogenic human papillomavirus types . BRITISH JOURNAL OF DERMATOLOGY . vol. 151 , 19 - 19 .

Harwood CA, Surentheran T, Sasieni P, Proby CM, Bordea C, Leigh IM, Wojnarowska F, Breuer J et al. ( 2004 ) . Increased risk of skin cancer associated with the presence of epidermodysplasia verruciformis human papillomavirus types in normal skin . Br J Dermatol vol. 150 , ( 5 ) 949 - 957 .

Langan JE, Cole CG, Huckle EJ, Byrne S, McRonald FE, Rowbottom L, Ellis A, Shaw JM et al. ( 2004 ) . Novel microsatellite markers and single nucleotide polymorphisms refine the tylosis with oesophageal cancer (TOC) minimal region on 17q25 to 42.5 kb: sequencing does not identify the causative gene . Hum Genet vol. 114 , ( 6 ) 534 - 540 .

Price RD, Das-Gupta V, Harris PA, Leigh IM, Navsaria HA ( 2004 ) . The role of allogenic fibroblasts in an acute wound healing model . Plast Reconstr Surg vol. 113 , ( 6 ) 1719 - 1729 .

Waseem A, Karsten U, Leigh IM, Purkis P, Waseem NH, Lane EB ( 2004 ) . Conformational changes in the rod domain of human keratin 8 following heterotypic association with keratin 18 and its implication for filament stability . Biochemistry vol. 43 , ( 5 ) 1283 - 1295 .

Ghali L, Wong S-T, Tidman N, Quinn A, Philpott MP, Leigh IM ( 2004 ) . Epidermal and hair follicle progenitor cells express melanoma-associated chondroitin sulfate proteoglycan core protein . J Invest Dermatol vol. 122 , ( 2 ) 433 - 442 .

LEIGH IM, Purkis P, Karsten U, Waseem A, Waseem NH, Lane EB ( 2004 ) . Conformational changes in the rod domain of human keratin 8 following hetreotypic association with keratin 18 and its implication for filament stability . Biochemistry vol. 10 , ( 43 ) 1283 - 1295 .

Leigh IM, Oliver RTD, PROWSE DM, Baithiun S, Youshya S ( 2004 ) . Detection of human papillomavirus and analysis of p16 expression in penile squamous cell carcinoma . European Journal of Cancer.

Harwood CA, LEIGH IM, South AP, McLean WH, Atherton DJ, Oyama N, Smith FJ, Al-Suwaid R et al. ( 2004 ) . Recurrent mutations in kindlin-1, a novel keratinocyte focal contact protein, in the autosomal recessive skin fragility and photosensitivity disorder, Kindler syndrome . J. Invest. Dermatol. vol. 122 , 78 - 83 .

Alam NA, Gorman P, Jaeger EEM, Kelsell D, Leigh IM, Ratnavel R, Murdoch ME, Houlston RS et al. ( 2003 ) . Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability . Cancer Genet Cytogenet vol. 147 , ( 2 ) 121 - 127 .

Legg J, Jensen UB, Broad S, Leigh I, Watt FM ( 2003 ) . Role of melanoma chondroitin sulphate proteoglycan in patterning stem cells in human interfollicular epidermis . DEVELOPMENT vol. 130 , ( 24 ) 6049 - 6063 .

Bowen SL, Bloor BK, Leigh IM, Waseem A ( 2003 ) . Adducin expression in cutaneous and oral lesions: alpha- and beta-adducin transcripts down-regulate with keratinocyte differentiation in stratified epithelia . J Pathol vol. 201 , ( 1 ) 119 - 126 .

South AP, Wan H, Stone MG, Dopping-Hepenstal PJC, Purkis PE, Marshall JF, Leigh IM, Eady RAJ et al. ( 2003 ) . Lack of plakophilin 1 increases keratinocyte migration and reduces desmosome stability . J CELL SCI vol. 116 , ( 16 ) 3303 - 3314 .

Jolliffe VM, O'Toole EA, Common JE, Kelsell DP, Yell JA, Paige DG, McKenna KE, Leigh IM ( 2003 ) . Clinical and molecular features of keratitis-ichthyosis-deafness syndrome . BRITISH JOURNAL OF DERMATOLOGY . vol. 149 , 80 - 80 .

Morley SM, D'Alessandro M, Sexton C, Rugg EL, Navsaria H, Shemanko CS, Huber M, Hohl D et al. ( 2003 ) . Generation and characterization of epidermolysis bullosa simplex cell lines: scratch assays show faster migration with disruptive keratin mutations . BRIT J DERMATOL vol. 149 , ( 1 ) 46 - 58 .

Hubbard VG, Leigh IM, Zakrzewska JM ( 2003 ) . Use of hydroxychloroquine in the treatment of oral and vulvovaginal lichen planus - a retrospective pilot study . BRITISH JOURNAL OF DERMATOLOGY . vol. 149 , 54 - 54 .

Alam NA, Rowan AJ, Wortham NC, Pollard PJ, Mitchell M, Tyrer JP, Barclay E, Calonje E et al. ( 2003 ) . Genetic and functional analyses of FH mutations in multiple cutaneous and uterine leiomyomatosis, hereditary leiomyomatosis and renal cancer, and fumarate hydratase deficiency . HUM MOL GENET vol. 12 , ( 11 ) 1241 - 1252 .

Kelsell D, Di WL, Monypenny J, Common J, Davies D, Leigh I, Zicha D ( 2003 ) . Cell death is characteristic of skin disease-associated connexin 31 mutations . BRITISH JOURNAL OF DERMATOLOGY . vol. 148 , 849 - 849 .

Rugg EL, Al-Rawi H, Leigh IM ( 2003 ) . Chemical chaperone-mediated supression of phenotype in epidermolysis bullosa simplex keratinocytes . BRITISH JOURNAL OF DERMATOLOGY . vol. 148 , 850 - 851 .

Russell D, Morley SM, D'Alessandro M, Leigh IM, Lane EB ( 2003 ) . Generation of patient cell lines to model epidermolysis bullosa simplex . BRITISH JOURNAL OF DERMATOLOGY . vol. 148 , 848 - 849 .

Norgett EE, Leigh IM, Kelsell DP ( 2003 ) . Genetic and immunohistochemical investigation of tight junction proteins in normal and hyperproliferative skin . BRITISH JOURNAL OF DERMATOLOGY . vol. 148 , 860 - 860 .

Bloor BK, Tidman N, Leigh IM, Odell E, Dogan B, Wollina U, Ghali L, Waseem A ( 2003 ) . Expression of keratin K2e in cutaneous and oral lesions: association with keratinocyte activation, proliferation, and keratinization . Am J Pathol vol. 162 , ( 3 ) 963 - 975 .

Harwood CA, McGregor JM, Swale VJ, Proby CM, Leigh IM, Newton R, Khorshid SM, Cerio R ( 2003 ) . High frequency and diversity of cutaneous appendageal tumors in organ transplant recipients . J Am Acad Dermatol vol. 48 , ( 3 ) 401 - 408 .

Passalidou E, Stewart M, Trivella M, Steers G, Pillai G, Dogan A, Leigh I, Hatton C et al. ( 2003 ) . Vascular patterns in reactive lymphoid tissue and in non-Hodgkin's lymphoma . BRIT J CANCER vol. 88 , ( 4 ) 553 - 559 .

Common JEA, Di W-L, Davies D, Galvin H, Leigh IM, O'Toole EA, Kelsell DP ( 2003 ) . Cellular mechanisms of mutant connexins in skin disease and hearing loss . Cell Commun Adhes . vol. 10 , 347 - 351 .

LEIGH IM, Waseem A, Ghali L, Wollina U, Odell E, Bloor BK, Tidman N, Dogan B ( 2003 ) . Expression of keratin k2e in cutaneous and oral lesions: association with keratinocyte activation, proliferation and keratinization . Am. J. Pathol. vol. 162 , 963 - 975 .

Eckl KM, Stevens HP, Lestringant GG, Westenberger-Treumann M, Traupe H, Hinz B, Frossard PM, Stadler R et al. ( 2003 ) . Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates . HUM GENET vol. 112 , ( 1 ) 50 - 56 .

Huen AC, Park JK, Godsel LM, Chen X, Bannon LJ, Amargo EV, Hudson TY, Mongui AK et al. ( 2002 ) . Intermediate filament-membrane attachments function synergistically with actin-dependent contacts to regulate intercellular adhesive strength . Journal of Cell Biology. vol. 159 , ( 6 ) 1005 - 1017 .

Common JEA, Becker D, Di W-L, Leigh IM, O'Toole EA, Kelsell DP ( 2002 ) . Functional studies of human skin disease- and deafness-associated connexin 30 mutations . Biochem Biophys Res Commun vol. 298 , ( 5 ) 651 - 656 .

Risk JM, Evans KE, Jones J, Langan JE, Rowbottom L, McRonald FE, Mills HS, Ellis A et al. ( 2002 ) . Characterization of a 500 kb region on 17q25 and the exclusion of candidate genes as the familial Tylosis Oesophageal Cancer (TOC) locus . Oncogene vol. 21 , ( 41 ) 6395 - 6402 .

Di WL, Monypenny J, Common JEA, Kennedy CTC, Holland KA, Rugg EL, Leigh IM, Zicha D et al. ( 2002 ) . Defective trafficking and cell death are characteristic of skin disease-associated connexin 31 mutations in keratinocytes . J INVEST DERMATOL vol. 119 , ( 3 ) 745 - 745 .

Queille S, Thibaudeau O, Soufir N, Leigh I, Dubertret L, Basset-Seguin N ( 2002 ) . Promoter hypermethylation of the INK4A-ARF locus in skin carcinomas . J INVEST DERMATOL vol. 119 , ( 3 ) 752 - 752 .

Harwood CA, Leigh IM, Proby CM ( 2002 ) . Skin problems in adult organ transplant recipients . J INVEST DERMATOL vol. 119 , ( 3 ) 760 - 760 .

Di W-L, Monypenny J, Common JEA, Kennedy CTC, Holland KA, Leigh IM, Rugg EL, Zicha D et al. ( 2002 ) . Defective trafficking and cell death is characteristic of skin disease-associated connexin 31 mutations . Hum Mol Genet vol. 11 , ( 17 ) 2005 - 2014 .

KELSELL DP, Leigh IM, Rugg EL, Holland KA, Monypenny J, Di WL, Zicha DI, Kennedy CTC et al. ( 2002 ) . Defective trafficking and cell death is characteristic of skin disease-associated Connexin 31 mutations . Human Molecular Genetics. vol. 11 , ( 17 ) 2005 - 2014 .

Philpott MP, NEILL GW, Leigh IM, Quinn AG, Ghali LR, Wong ST, Teh MT ( 2002 ) . FOXM1 is a downstream target of Gli1 in basal cell carcinomas . Cancer Res. vol. 62 , ( 16 ) 4773 - 4780 .

McGregor JM, Harwood CA, Brooks L, Fisher SA, Kelly DA, O'nions J, Young AR, Surentheran T et al. ( 2002 ) . Relationship between p53 codon 72 polymorphism and susceptibility to sunburn and skin cancer . J Invest Dermatol vol. 119 , ( 1 ) 84 - 90 .

Rugg EL, Common JEA, Wilgoss A, Stevens HP, Buchan J, Leigh IM, Kelsell DP ( 2002 ) . Diagnosis and confirmation of epidermolytic palmoplantar keratoderma by the identification of mutations in keratin 9 using denaturing high-performance liquid chromatography . Br J Dermatol vol. 146 , ( 6 ) 952 - 957 .

Common JEA, Di W, Leigh IM, Kelsell DP ( 2002 ) . Genetic and functional analysis of connexins in skin disease and deafness . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 10 , 68 - 68 .

Hennies HC, Eckl KM, Stevens HP, Lestringant GG, Westenberger-Treumann M, Traupe H, Frossard PM, Stadler R et al. ( 2002 ) . Mutations in the gene for SLURP-1 in patients with Mal de Meleda (MIDM) with recessive and pseudo-dominant inheritance . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 10 , 246 - 246 .

Tomlinson IPM, Alam NA, Rowan AJ, Barclay E, Jaeger EEM, Kelsell D, Leigh I, Gorman P et al. ( 2002 ) . Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer . Nat Genet vol. 30 , ( 4 ) 406 - 410 .

Passalidou E, Trivella M, Singh N, Ferguson M, Hu J, Cesario A, Granone P, Nicholson AG et al. ( 2002 ) . Vascular phenotype in angiogenic and non-angiogenic lung non-small cell carcinomas . BRIT J CANCER vol. 86 , ( 2 ) 244 - 249 .

Kelsell DP, Di W, Common JEA, Holland KA, Rugg EL, Leigh IM ( 2002 ) . Erratum: Functional analyses of connexin mutations in keratinocytes (Journal of Investigative Dermatology (September 2001) 117: 3 (775)) . Journal of Investigative Dermatology vol. 118 , ( 4 )

Terrinoni A, Smith FJ, Didona B, Canzona F, Paradisi M, Huber M, Hohl D, David A et al. ( 2001 ) . Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita . J Invest Dermatol vol. 117 , ( 6 ) 1391 - 1396 .

Eckl KM, Stevens HP, Lestringant GG, Frossard PM, Leigh IM, Nurnberg P, Reis A, Hennies HC ( 2001 ) . Mal de Meleda (MDM) is caused by mutations in the SLURP-1 gene in patients from Palestine and the United Arab Emirates . AM J HUM GENET vol. 69 , ( 4 ) 613 - 613 .

Di WL, Rugg EL, Leigh IM, Kelsell DP ( 2001 ) . Multiple epidermal connexins are expressed in different keratinocyte subpopulations including connexin 31 . J Invest Dermatol vol. 117 , ( 4 ) 958 - 964 .

Kelsell DP, Di W, Common JEA, Rugg EL, Leigh IM ( 2001 ) . Functional analyses of connexin mutations in keratinocytes . J INVEST DERMATOL vol. 117 , ( 3 ) 775 - 775 .

Terrinoni A, Smith FJD, Didona B, Paradisi M, Huber M, Hohl D, David A, Verloes A et al. ( 2001 ) . Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita . J INVEST DERMATOL vol. 117 , ( 3 ) 797 - 797 .

Selvaratnam L, Cruchley AT, Navsaria H, Wertz PW, Hagi-Pavli EP, Leigh IM, Squier CA, Williams DM ( 2001 ) . Permeability barrier properties of oral keratinocyte cultures: a model of intact human oral mucosa . Oral Dis vol. 7 , ( 4 ) 252 - 258 .

Orteu CH, Buchanan JA, Hutchison I, Leigh IM, Bull RH ( 2001 ) . Systemic lupus erythematosus presenting with oral mucosal lesions: easily missed? . Br J Dermatol vol. 144 , ( 6 ) 1219 - 1223 .

Sampson JH, Raman A, Karlsen G, Navsaria H, Leigh IM ( 2001 ) . In vitro keratinocyte antiproliferant effect of Centella asiatica extract and triterpenoid saponins . Phytomedicine vol. 8 , ( 3 ) 230 - 235 .

Alam NA, Bevan S, Churchman M, Barclay E, Barker K, Jaeger EE, Nelson HM, Healy E et al. ( 2001 ) . Localization of a gene (MCUL1) for multiple cutaneous leiomyomata and uterine fibroids to chromosome 1q42.3-q43 . Am J Hum Genet vol. 68 , ( 5 ) 1264 - 1269 .

Hatsell SJ, Eady RA, Wennerstrand L, Dopping-Hepenstal P, Leigh IM, Munro C, Kelsell DP ( 2001 ) . Novel splice site mutation in keratin 1 underlies mild epidermolytic palmoplantar keratoderma in three kindreds . J Invest Dermatol vol. 116 , ( 4 ) 606 - 609 .

Ola A, Waga S, Ellison V, Stillman B, McGurk M, Leigh IM, Waseem NH, Waseem A ( 2001 ) . Human-Saccharomyces cerevisiae proliferating cell nuclear antigen hybrids: oligomeric structure and functional characterization using in vitro DNA replication . J Biol Chem vol. 276 , ( 13 ) 10168 - 10177 .

Hunt DM, Rickman L, Whittock NV, Eady RA, Simrak D, Dopping-Hepenstal PJ, Stevens HP, Armstrong DK et al. ( 2001 ) . Spectrum of dominant mutations in the desmosomal cadherin desmoglein 1, causing the skin disease striate palmoplantar keratoderma . Eur J Hum Genet vol. 9 , ( 3 ) 197 - 203 .

Fear MW, Hatsell SJ, Leigh IM, Kelsell DP ( 2001 ) . Whats new in genodermatoses? . Keio J Med vol. 50 , ( 1 ) 35 - 38 .

Virtanen M, Gedde-Dahl T, Mörk NJ, Leigh I, Bowden PE, Vahlquist A ( 2001 ) . Phenotypic/genotypic correlations in patients with epidermolytic hyperkeratosis and the effects of retinoid therapy on keratin expression . Acta Derm Venereol vol. 81 , ( 3 ) 163 - 170 .

Ishida-Yamamoto A, Kelsell D, Common J, Houseman MJ, Hashimoto M, Shibaki H, Asano K, Takahashi H et al. ( 2000 ) . A case of erythrokeratoderma variabilis without mutations in connexin 31 . BRIT J DERMATOL vol. 143 , ( 6 ) 1283 - 1287 .

Popp S, Waltering S, Holtgreve-Grez H, Jauch A, Proby C, Leigh IM, Boukamp P ( 2000 ) . Genetic characterization of a human skin carcinoma progression model: from primary tumor to metastasis . J INVEST DERMATOL vol. 115 , ( 6 ) 1095 - 1103 .

Kelsell DP, Norgett EE, Hatsell SJ, Common JEA, Cabezas JCR, Stevens HP, Carvajal-Huerta L, Leigh IM ( 2000 ) . Recessive mutation in desmoplakin disrupts desmoplakin/intermediate filament interactions and causes dilated cardiomyopathy, woolly hair and keratoderma . J INVEST DERMATOL vol. 115 , ( 6 ) 1170 - 1170 .

Norgett EE, Hatsell SJ, Carvajal-Huerta L, Cabezas JCR, Common J, Purkis PE, Whittock N, Leigh IM et al. ( 2000 ) . Recessive mutation in desmoplakin disrupts desmoplakin-intermediate filament interactions and causes dilated cardiomyopathy, woolly hair and keratoderma . Human Molecular Genetics vol. 9 , ( 18 ) 2761 - 2766 .

Kelsell DP, Wilgoss AL, Richard G, Stevens HP, Munro CS, Leigh IM ( 2000 ) . Erratum: Connexin mutations associated with palmoplantar keratoderma and profound deafness in a single family (European Journal of Human Genetics (2000) 8 (141-144)) . European Journal of Human Genetics vol. 8 , ( 6 ) 468 - 472 .

Harwood CA, Surentheran T, McGregor JM, Spink PJ, Leigh IM, Breuer J, Proby CM ( 2000 ) . Human papillomavirus infection and non-melanoma skin cancer in immunosuppressed and immunocompetent individuals . Journal of Medical Virology vol. 61 , ( 3 ) 289 - 297 .

Bignell GR, Warren W, Seal S, Takahashi M, Rapley E, Barfoot R, Green H, Brown C et al. ( 2000 ) . Identification of the familial cylindromatosis tumour-suppressor gene . Nat Genet vol. 25 , ( 2 ) 160 - 165 .

Kelsell DP, Wilgoss AL, Richard G, Stevens HP, Munro CS, Leigh IM ( 2000 ) . Connexin mutations associated with palmoplantar keratoderma and profound deafness in a single family . European Journal of Human Genetics vol. 8 , ( 2 ) 141 - 144 .

Talas U, Dunlop J, Khalaf S, Leigh IM, Kelsell DP ( 2000 ) . Human elastase 1: Evidence for expression in the skin and the identification of a frequent frameshift polymorphism . Journal of Investigative Dermatology vol. 114 , ( 1 ) 165 - 170 .

Chavanas S, Garner C, Bodemer C, Ali M, Hamel-Teillac D, Wilkinson J, Bonafé JL, Paradisi M et al. ( 2000 ) . Localization of the Netherton syndrome gene to chromosome 5q32, by linkage analysis and homozygosity mapping . American Journal of Human Genetics vol. 66 , ( 3 ) 914 - 921 .

Chakrabarty KH, Dawson RA, Harris P, Layton C, Babu M, Gould L, Phillips J, Leigh I et al. ( 1999 ) . Development of autologous human dermal-epidermal composites based on sterilized human allodermis for clinical use . Br J Dermatol vol. 141 , ( 5 ) 811 - 823 .

Leigh IM, Buchanan AG, Harwood CA, Cerio R, Storey A ( 1999 ) . Role of human papillomaviruses in cutaneous and oral manifestations of immunosuppression . Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology vol. 21 , ( 4 SUPPL. )

Wojnarowska F, Allen J, Collier PM, Leigh IM ( 1999 ) . A comparison of the expression of known basement membrane components with the linear IgA disease antigens using the novel substrate cylindroma . British Journal of Dermatology vol. 141 , ( 1 ) 62 - 70 .

Risk JM, Ruhrberg C, Hennies HC, Mills HS, Di Colandrea T, Evans KE, Ellis A, Watt FM et al. ( 1999 ) . Envoplakin, a possible candidate gene for focal NEPPK/esophageal cancer (TOC): The integration of genetic and physical maps of the TOC region on 17q25 . Genomics vol. 59 , ( 2 ) 234 - 242 .

Rickman L, Šimrak D, Stevens HP, Hunt DM, King IA, Bryant SP, Eady RAJ, Leigh IM et al. ( 1999 ) . N-terminal deletion in a desmosomal cadherin causes the autosomal dominant skin disease striate palmoplantar keratoderma . Human Molecular Genetics vol. 8 , ( 6 ) 971 - 976 .

Kupsch JM, Tidman NH, Kang NV, Truman H, Hamilton S, Patel N, Newton Bishop JA, Leigh IM et al. ( 1999 ) . Isolation of human tumor-specific antibodies by selection of an antibody phage library on melanoma cells . Clin Cancer Res vol. 5 , ( 4 ) 925 - 931 .

McLean WH, Morley SM, Higgins C, Bowden PE, White M, Leigh IM, Lane EB ( 1999 ) . Novel and recurrent mutations in keratin 10 causing bullous congenital ichthyosiform erythroderma . Exp Dermatol vol. 8 , ( 2 ) 120 - 123 .

Harwood CA, Spink PJ, Surentheran T, Leigh IM, De Villiers EM, McGregor JM, Proby CM, Breuer J ( 1999 ) . Degenerate and nested PCR: A highly sensitive and specific method for detection of human papillomavirus infection in cutaneous warts . Journal of Clinical Microbiology vol. 37 , ( 11 ) 3545 - 3555 .

Kelsell DP, Stevens HP, Purkis PE, Talas U, Rustin MHA, Leigh IM ( 1999 ) . Fine genetic mapping of diffuse non-epidermolytic palmoplantar keratoderma to chromosome 12q11-q13: Exclusion of the mapped type II keratins . Experimental Dermatology vol. 8 , ( 5 ) 388 - 391 .

Wilgoss A, Leigh IM, Barnes MR, Dopping-Hepenstal P, Eady RAJ, Walter JM, Kennedy CTC, Kelsell DP ( 1999 ) . Identification of a novel mutation R42P in the gap junction protein β-3 associated with autosomal dominant erythrokeratoderma variabilis . Journal of Investigative Dermatology vol. 113 , ( 6 ) 1119 - 1122 .

Waseem A, Dogan B, Tidman N, Alam Y, Purkis P, Jackson S, Lalli A, Machesney M et al. ( 1999 ) . Keratin 15 expression in stratified epithelia: Downregulation in activated keratinocytes . Journal of Investigative Dermatology vol. 112 , ( 3 ) 362 - 369 .

Waseem A, Alam Y, Dogan B, White KN, Leigh IM, Waseem NH ( 1998 ) . Erratum: Isolation, sequence and expression of the gene encoding human keratin 13 (Gene (1998) 215 (269-279) PII: S0378111997002972) . Gene vol. 221 , ( 2 )

Waseem A, Alam Y, Dogan B, White KN, Leigh IM, Waseem NH ( 1998 ) . Isolation, sequence and expression of the gene encoding human keratin 13 . Gene vol. 215 , ( 2 ) 269 - 279 .

Storey A, Thomas M, Kalita A, Harwood C, Gardiol D, Mantovani F, Breuer J, Leigh IM et al. ( 1998 ) . Role of a p53 polymorphism in the development of human papilloma-virus- associated cancer . Nature vol. 393 , ( 6682 ) 229 - 234 .

Machesney M, Tidman N, Waseem A, Kirby L, Leigh I ( 1998 ) . Activated keratinocytes in the epidermis of hypertrophic scars . American Journal of Pathology vol. 152 , ( 5 ) 1133 - 1141 .

Storey A, Harwood C, Matlashewski G, Thomas M, Breuer J, Leigh I, Gardiol D, Kalita A et al. ( 1998 ) . A genetic polymorphism determines susceptibility to human papillomavirus associated cancers . Journal of Dermatological Science vol. 16 ,

Surentheran T, Harwood CA, Spink PJ, Sinclair AL, Leigh IM, Proby CM, McGregor JM, Breuer J ( 1998 ) . Detection and typing of human papillomaviruses in mucosal and cutaneous biopsies from immunosuppressed and immunocompetent patients and patients with epidermodysplasia verruciformis: A unified diagnostic approach . Journal of Clinical Pathology vol. 51 , ( 8 ) 606 - 610 .

Harwood CA, Spink PJ, Surentheran T, Leigh IM, Hawke JLM, Proby CM, Breuer J, McGregor JM ( 1998 ) . Detection of human papillomavirus DNa in PUVA-associated non-melanoma skin cancers . Journal of Investigative Dermatology vol. 111 , ( 1 ) 123 - 127 .

McGrath JA, McMillan JR, Shemanko CS, Runswick SK, Leigh IM, Lane EB, Garrod DR, Eady RA ( 1997 ) . Mutations in the plakophilin 1 gene result in ectodermal dysplasia/skin fragility syndrome . Nat Genet vol. 17 , ( 2 ) 240 - 244 .

Kelsell DP, Dunlop J, Stevens HP, Lench NJ, Liang JN, Parry G, Mueller RF, Leigh IM ( 1997 ) . Connexin 26 mutations in hereditary non-syndromic sensorineural deafness . Nature vol. 387 , ( 6628 ) 80 - 83 .

Westgate GE, Tidman N, De Berker D, Blount MA, Philpott MP, Leigh IM ( 1997 ) . Characterization of LHTric-1, a new monospecific monoclonal antibody to the trichocyte keratin Ha1 . British Journal of Dermatology vol. 137 , ( 1 ) 24 - 30 .

Field EA, Ellis A, Friedmann PS, Leigh IM, Field JK ( 1997 ) . Oral tylosis: A re-appraisal . European Journal of Cancer Part B: Oral Oncology vol. 33 , ( 1 ) 55 - 57 .

Mellerio JE, Smith FJD, McMillan JR, McLean WHI, McGrath JA, Morrison GAJ, Tierney P, Albert DM et al. ( 1997 ) . Recessive epidermolysis bullosa simplex associated with plectin mutations: Infantile respiratory complications in two unrelated cases . British Journal of Dermatology vol. 137 , ( 6 ) 898 - 906 .

Smith FJD, Eady RAJ, Leigh IM, McMillan JR, Rugg EL, Kelsell DP, Bryant SP, Spurr NK et al. ( 1996 ) . Plectin deficiency results in muscular dystrophy with epidermolysis bullosa . Nature Genetics vol. 13 , ( 4 ) 450 - 457 .

Kelsell DP, Risk JM, Leigh IM, Stevens HP, Ellis A, Hennies HC, Reis A, Weissenbach J et al. ( 1996 ) . Close mapping of the focal non-epidermolytic palmoplantar keratoderma (PPK) locus associated with oesophageal cancer (TOC) . Human Molecular Genetics vol. 5 , ( 6 ) 857 - 860 .

Stevens HP, Kelsell DP, Bryant SP, Bishop DT, Spurr NK, Weissenbach J, Marger D, Marger RS et al. ( 1996 ) . Linkage of an American pedigree with palmoplantar keratoderma and malignancy (palmoplantar ectodermal dysplasia type III) to 17q24: Literature survey and proposed updated classification of the keratodermas . Archives of Dermatology vol. 132 , ( 6 ) 640 - 651 .

Stevens HP, Kelsell DP, Bryant SP, Bishop DT, Dawber RPR, Spurr NK, Leigh IM ( 1996 ) . Linkage of monilethrix to the trichocyte and epithelial keratin gene cluster on 12q11-q13 . Journal of Investigative Dermatology vol. 106 , ( 4 ) 795 - 797 .

Robinson CM, Di Biase AT, Leigh IM, Williams DM, Thornhill MH ( 1996 ) . Oral psoriasis . British Journal of Dermatology vol. 134 , ( 2 ) 347 - 349 .

Stevens HP, Kelsell DP, Leigh IM, Ostlere LS, Macdermot KD, Rustin MHA ( 1996 ) . Punctate palmoplantar keratoderma and malignancy in a four-generation family . British Journal of Dermatology vol. 134 , ( 4 ) 720 - 726 .

Kelsell DP, Stevens HP, Ratnavel R, Bryant SP, Bishop DT, Leigh IM, Spurr NK ( 1995 ) . Genetic linkage studies in non-epidermolytic palmoplantar keratoderma: Evidence for heterogeneity . Human Molecular Genetics vol. 4 , ( 6 ) 1021 - 1025 .

King GN, Healy CM, Glover MT, Kwan JTC, Williams DM, Leigh IM, Worthington HV, Thornhill MH ( 1995 ) . Increased prevalence of dysplastic and malignant lip lesions in renal-transplant recipients . New England Journal of Medicine vol. 332 , ( 16 ) 1052 - 1057 .

Farthing PM, Maragou P, Coates M, Tatnall F, Leigh IM, Williams DM ( 1995 ) . Characteristics of the oral lesions in patients with cutaneous recurrent erythema multiforme . Journal of Oral Pathology & Medicine vol. 24 , ( 1 ) 9 - 13 .

Bryan D, Sexton CJ, Williams D, Leigh IM, McKay IA ( 1995 ) . Oral keratinocytes immortalized with the early region of human papillomavirus type 16 show elevated expression of interleukin 6, which acts as an autocrine growth factor for the derived T103C cell line . Cell Growth and Differentiation vol. 6 , ( 10 ) 1245 - 1250 .

Risk JM, Field EA, Field JK, Whittaker J, Fryer A, Ellis A, Shaw JM, Friedmann PS et al. ( 1994 ) . Tylosis oesophageal cancer mapped . Nat Genet vol. 8 , ( 4 ) 319 - 321 .

Bustin SA, Nie XF, Barnard RC, Kumar V, Pascall JC, Brown KD, Leigh IM, Williams NS et al. ( 1994 ) . Cloning and characterization of ERF-1, a human member of the Tis11 family of early-response genes . DNA Cell Biol vol. 13 , ( 5 ) 449 - 459 .

King GN, Healy CM, Glover MT, Kwan JTC, Williams DM, Leigh IM, Thornhill MH ( 1994 ) . Prevalence and risk factors associated with leukoplakia, hairy leukoplakia, erythematous candidiasis, and gingival hyperplasia in renal transplant recipients . Oral Surgery, Oral Medicine, Oral Pathology vol. 78 , ( 6 ) 718 - 726 .

SCHOFIELD JK, TATNALL FM, BROWN J, MCCLOSKEY D, NAVARRETE C, LEIGH IM ( 1994 ) . Recurrent erythema multiforme: tissue typing in a large series of patients . British Journal of Dermatology vol. 131 , ( 4 ) 532 - 535 .

Williams AT, Sexton CJ, Sinclair AL, Purdie KJ, Thomas MS, Hanna NA, Goh BT, Williams DM et al. ( 1994 ) . Retention of low copy number human papillomavirus DNA in cultured cutaneous and mucosal wart keratinocytes . Journal of General Virology vol. 75 , ( 3 ) 505 - 511 .

Ellis A, Field JK, Field EA, Friedmann PS, Fryer A, Howard P, Leigh IM, Risk J et al. ( 1994 ) . Tylosis associated with carcinoma of the oesophagus and oral leukoplakia in a large Liverpool family--a review of six generations . Eur J Cancer B Oral Oncol vol. 30B , ( 2 ) 102 - 112 .

Markey AC, Lane EB, Macdonald DM, Leigh IM ( 1992 ) . Keratin expression in basal cell carcinomas . Br J Dermatol vol. 126 , ( 2 ) 154 - 160 .

Markey AC, Lane EB, Churchill LJ, MacDonald DM, Leigh IM ( 1991 ) . Expression of simple epithelial keratins 8 and 18 in epidermal neoplasia . J Invest Dermatol vol. 97 , ( 5 ) 763 - 770 .

Langdon J, Williams DM, Navsaria H, Leigh IM ( 1991 ) . Autologous keratinocyte grafting: A new technique for intra-oral reconstruction . British Dental Journal vol. 171 , ( 3 ) 87 - 90 .

Williams DM, Leigh IM, Greenspan D, Greenspan JS ( 1991 ) . Altered patterns of keratin expression in oral hairy leukoplakia: prognostic implications . Journal of Oral Pathology & Medicine vol. 20 , ( 4 ) 167 - 171 .

Langdon JD, Leigh IM, Navsaria HA, Williams DM ( 1990 ) . Autologous oral keratinocyte grafts in the mouth . The Lancet vol. 335 , ( 8703 ) 1472 - 1473 .

Venning V, Whitehead PH, Leigh IM, Allen J, Wojnarowska F ( 1990 ) . Clinical variants of bullous pemphigoid are not determined by the specificity of the target antigen defined by immunoblotting . British Journal of Dermatology . vol. 123 ,

Gao Z, Mackenzie IC, Cruchley AT, Williams DM, Leigh I, Lane EB ( 1989 ) . Cytokeratin expression of the odontogenic epithelia in dental follicles and developmental cysts . Journal of Oral Pathology & Medicine vol. 18 , ( 2 ) 63 - 67 .

Gao Z, Mackenzie IC, Williams DM, Cruchley AT, Leigh I, Lane EB ( 1988 ) . Patterns of keratin‐expression in rests of Malassez and periapical lesions . Journal of Oral Pathology & Medicine vol. 17 , ( 4 ) 178 - 185 .

WRIGHT S, LEMOINE NR, LEIGH IM ( 1986 ) . Woolly hair naevi with systematized linear epidermal naevus . Clinical and Experimental Dermatology vol. 11 , ( 2 ) 179 - 182 .