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Publications:  Prof Irene Leigh

McHugh A, Fernandes K, Chinner N, Ibrahim AFM, Garg AK, Boag G, Hepburn LA, Proby CM et al.(2020). The Identification of Potential Therapeutic Targets for Cutaneous Squamous Cell Carcinoma. Journal of Investigative Dermatology vol. 140, (6) 1154-1165.e5.
10.1016/j.jid.2019.09.024
https://qmro.qmul.ac.uk/xmlui/handle/123456789/65193
Venables ZC, Nijsten T, Wong KF, Autier P, Broggio J, Deas A, Harwood CA, Hollestein LM et al.(2019). Epidemiology of basal and cutaneous squamous cell carcinoma in the U.K. 2013–15: a cohort study. British Journal of Dermatology vol. 181, (3) 474-482.
10.1111/bjd.17873
Hassan S, Purdie KJ, Wang J, Harwood CA, Proby CM, Pourreyron C, Mladkova N, Nagano A et al.(2019). A unique panel of patient-derived cutaneous squamous cell carcinoma cell lines provides a preclinical pathway for therapeutic testing. International Journal of Molecular Sciences vol. 20, (14)
10.3390/ijms20143428
https://qmro.qmul.ac.uk/xmlui/handle/123456789/60808
Leigh IM, Proby CM, Inman GJ, Harwood CA(2019). Azathioprine: friend or foe?. British Journal of Dermatology vol. 180, (5) 961-963.
10.1111/bjd.17345
https://qmro.qmul.ac.uk/xmlui/handle/123456789/65249
Bottomley MJ, Thomson J, Harwood C, Leigh I(2019). The role of the immune system in cutaneous squamous cell carcinoma. International Journal of Molecular Sciences vol. 20, (8)
10.3390/ijms20082009
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62055
Kalin JH, Eroglu A, Liu H, Holtzclaw WD, Leigh I, Proby CM, Fahey JW, Cole PA et al.(2019). Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model. PLOS ONE vol. 14, (3) e0213095-e0213095.
10.1371/journal.pone.0213095
Inman GJ, Wang J, Nagano A, Alexandrov LB, Purdie KJ, Taylor RG, Sherwood V, Thomson J et al.(2018). The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature. Nature Communications vol. 9, (1)
10.1038/s41467-018-06027-1
https://qmro.qmul.ac.uk/xmlui/handle/123456789/46163
LEIGH IM, VENABLES Z, Autier P, Nijsten T, Wong K, Langan S, Rous B, Broggio J et al.(2018). Nationwide Incidence of Metastatic Cutaneous Squamous Cell Carcinoma in England. JAMA Dermatology
10.1001/jamadermatol.2018.4219
https://qmro.qmul.ac.uk/xmlui/handle/123456789/53563
Purdie KJ, Proby CM, Rizvi H, Griffin H, Doorbar J, Sommerlad M, Feltkamp MC, der Meijden EV et al.(2018). The Role of Human Papillomaviruses and Polyomaviruses in BRAF-Inhibitor Induced Cutaneous Squamous Cell Carcinoma and Benign Squamoproliferative Lesions. Frontiers in Microbiology vol. 9, 1806-1806.
10.3389/fmicb.2018.01806
https://qmro.qmul.ac.uk/xmlui/handle/123456789/44790
Hepburn LA, McHugh A, Fernandes K, Boag G, Proby CM, Leigh IM, Saville MK(2018). Targeting the spliceosome for cutaneous squamous cell carcinoma therapy: a role for c-MYC and wild-type p53 in determining the degree of tumour selectivity. Oncotarget vol. 9, (33) 23029-23046.
10.18632/oncotarget.25196
https://qmro.qmul.ac.uk/xmlui/handle/123456789/51785
McHugh A, Fernandes K, South AP, Mellerio JE, Salas-Alanís JC, Proby CM, Leigh IM, Saville MK(2018). Preclinical comparison of proteasome and ubiquitin E1 enzyme inhibitors in cutaneous squamous cell carcinoma: the identification of mechanisms of differential sensitivity. Oncotarget vol. 9, (29) 20265-20281.
10.18632/oncotarget.24750
https://qmro.qmul.ac.uk/xmlui/handle/123456789/51623
Rose AM, Spender LC, Stephen C, Mitchell A, Rickaby W, Bray S, Evans AT, Dayal J et al.(2018). Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma. Oncotarget vol. 9, (18) 14552-14566.
10.18632/oncotarget.24545
https://qmro.qmul.ac.uk/xmlui/handle/123456789/44791
Lai K, Harwood CA, Purdie KJ, Proby CM, Leigh IM, Ravi N, Mully TW, Brooks L et al.(2017). Genomic analysis of atypical fibroxanthoma. PLoS One vol. 12, (11) e0188272-e0188272.
10.1371/journal.pone.0188272
https://qmro.qmul.ac.uk/xmlui/handle/123456789/44644
Maruthappu T, Chikh A, Fell B, Delaney PJ, Brooke MA, Levet C, Moncada-Pazos A, Ishida-Yamamoto A et al.(2017). Rhomboid family member 2 Regulates cytoskeletal stress associated Keratin 16. Nature Communications vol. 8, 14174-14174.
10.1038/ncomms14174
https://qmro.qmul.ac.uk/xmlui/handle/123456789/19007
Cammareri P, Rose AM, Vincent DF, Wang J, Nagano A, Libertini S, Ridgway RA, Athineos D et al.(2016). Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma. Nature Communications vol. 7, 12493-12493.
10.1038/ncomms12493
https://qmro.qmul.ac.uk/xmlui/handle/123456789/31383
Watt SA, Purdie KJ, den Breems NY, Dimon M, Tucker S, Arron ST, McHugh A, Xue DJ et al.(2016). CREBBP mutation in human cutaneous squamous cell carcinoma. Experimental Dermatology vol. 25, (8) 650-651.
10.1111/exd.13044
https://qmro.qmul.ac.uk/xmlui/handle/123456789/65536
Harwood CA, Proby CM, Inman GJ, Leigh IM(2016). The promise of genomics and the development of targeted therapies for cutaneous squamous cell carcinoma. Acta Dermato-Venereologica vol. 96, (1)
10.2340/00015555-2181
Watt SA, Purdie KJ, Den Breems NY, Dimon M, Arron ST, McHugh AT, Xue DJ, Dayal JHS et al.(2015). Novel CARD11 Mutations in Human Cutaneous Squamous Cell Carcinoma Lead to Aberrant NF-κB Regulation. American Journal of Pathology vol. 185, (9) 2354-2363.
10.1016/j.ajpath.2015.05.018
South AP, Purdie KJ, Watt SA, Haldenby S, den Breems N, Dimon M, Arron ST, Kluk MJ et al.(2014). NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis. J Invest Dermatol vol. 134, (10) 2630-2638.
10.1038/jid.2014.154
Lambert SR, Mladkova N, Gulati A, Hamoudi R, Purdie K, Cerio R, Leigh I, Proby C et al.(2013). Key differences identified between actinic keratosis and cutaneous squamous cell carcinoma by transcriptome profiling. Br J Cancer vol. 110, (2) 520-529.
10.1038/bjc.2013.760
Blaydon DC, Lind LK, Plagnol V, Linton KJ, Smith FJD, Wilson NJ, McLean WHI, Munro CS et al.(2013). Mutations in AQP5, encoding a water-channel protein, cause autosomal-dominant diffuse nonepidermolytic palmoplantar keratoderma. American Journal of Human Genetics vol. 93, (2) 330-335.
10.1016/j.ajhg.2013.06.008
Matin RN, Chikh A, Chong SLP, Mesher D, Graf M, Sanza P, Senatore V, Scatolini M et al.(2013). p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis. Journal of Experimental Medicine vol. 210, (3) 581-603.
10.1084/jem.20121439
https://qmro.qmul.ac.uk/xmlui/handle/123456789/7963
Harwood CA, Mesher D, McGregor JM, Mitchell L, Leedham-Green M, Raftery M, Cerio R, Leigh IM et al.(2013). A surveillance model for skin cancer in organ transplant recipients: A 22-year prospective study in an ethnically diverse population. American Journal of Transplantation vol. 13, (1) 119-129.
10.1111/j.1600-6143.2012.04292.x
Nigro CL, Wang H, McHugh A, Lattanzio L, Matin R, Harwood C, Syed N, Hatzimichael E et al.(2013). Methylated tissue factor pathway inhibitor 2 (TFPI2) DNA in serum is a biomarker of metastatic melanoma. Journal of Investigative Dermatology vol. 133, (5) 1278-1285.
10.1038/jid.2012.493
Lambert SR, Harwood CA, Purdie KJ, Gulati A, Matin RN, Romanowska M, Cerio R, Kelsell DP et al.(2012). Metastatic cutaneous squamous cell carcinoma shows frequent deletion in the protein tyrosine phosphatase receptor Type D gene. International Journal of Cancer vol. 131, (3)
10.1002/ijc.27333
Wang H, Lee S, Lo Nigro C, Lattanzio L, Merlano M, Monteverde M, Matin R, Purdie K et al.(2012). NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity. British Journal of Cancer vol. 106, (8) 1446-1452.
10.1038/bjc.2012.95
https://qmro.qmul.ac.uk/xmlui/handle/123456789/7999
Blaydon DC, Etheridge SL, Risk JM, Hennies HC, Gay LJ, Carroll R, Plagnol V, McRonald FE et al.(2012). RHBDF2 mutations are associated with tylosis, a familial esophageal cancer syndrome. American Journal of Human Genetics vol. 90, (2) 340-346.
10.1016/j.ajhg.2011.12.008
Ismail F, Ikram M, Purdie K, Harwood C, Leigh I, Storey A(2011). Cutaneous squamous cell carcinoma (scc) and the DNA damage response: Patm expression patterns in Pre-Malignant and malignant keratinocyte skin lesions. PLoS ONE vol. 6, (7)
10.1371/journal.pone.0021271
https://qmro.qmul.ac.uk/xmlui/handle/123456789/5404
Watt SA, Pourreyron C, Purdie K, Hogan C, Cole CL, Foster N, Pratt N, Bourdon J-C et al.(2011). Integrative mRNA profiling comparing cultured primary cells with clinical samples reveals PLK1 and C20orf20 as therapeutic targets in cutaneous squamous cell carcinoma. Oncogene vol. 30, (46) 4666-4677.
10.1038/onc.2011.180
Oji V, Tadini G, Akiyama M, Blanchet Bardon C, Bodemer C, Bourrat E, Coudiere P, Digiovanna JJ et al.(2010). Revised nomenclature and classification of inherited ichthyoses: Results of the First Ichthyosis Consensus Conference in Sorze 2009. Journal of the American Academy of Dermatology vol. 63, (4) 607-641.
10.1016/j.jaad.2009.11.020
Purdie KJ, Harwood CA, Gibbon K, Chaplin T, Young BD, Cazier JB, Singh N, Leigh IM et al.(2010). High-resolution genomic profiling of human papillomavirus-associated vulval neoplasia. Br J Cancer vol. 102, (6) 1044-1051.
10.1038/sj.bjc.6605589
Purdie KJ, Pourreyron C, Fassihi H, Cepeda-Valdes R, Frew JW, Volz A, Weissenborn SJ, Pfister H et al.(2010). No evidence that human papillomavirus is responsible for the aggressive nature of recessive dystrophic epidermolysis bullosa-associated squamous cell carcinoma. Journal of Investigative Dermatology vol. 130, (12) 2853-2855.
10.1038/jid.2010.243
Gibbon KL, Ekeowa-Anderson AL, Leigh IM(2009). External anogenital premalignant and malignant disease.
Purdie KJ, Harwood CA, Gulati A, Chaplin T, Lambert SR, Cerio R, Kelly GP, Cazier J-B et al.(2009). Single nucleotide polymorphism array analysis defines a specific genetic fingerprint for well-differentiated cutaneous SCCs. J Invest Dermatol vol. 129, (6) 1562-1568.
10.1038/jid.2008.408
Wong T, Gammon L, Liu L, Mellerio JE, Dopping-Hepenstal PJC, Pacy J, Elia G, Jeffery R et al.(2008). Potential of fibroblast cell therapy for recessive dystrophic epidermolysis bullosa. J INVEST DERMATOL vol. 128, (9) 2179-2189.
10.1038/jid.2008.78
Damodaran G, Syed M, Leigh I, Myers S, Navsaria H(2008). Clinical application of skin substitutes. Expert Review of Dermatology vol. 3, (3) 345-356.
10.1586/17469872.3.3.345
Lalli A, Tilakaratne WM, Ariyawardana A, Fitchett C, Leigh IM, Hagi-Pavli E, Cruchley AT, Parkinson EK et al.(2008). An altered keratinocyte phenotype in oral submucous fibrosis: correlation of keratin K17 expression with disease severity. J ORAL PATHOL MED vol. 37, (4) 211-220.
10.1111/j.1600-0714.2007.00609.x
Wong T, Gammon L, Liu L, Ozoemena L, Dopping-Hepenstal PJC, Jones C, Leigh IM, McGrath JA et al.(2007). Intradermal injection of allogeneic normal human fibroblasts promotes type VII collagen deposition at the dermal-epidermal junction in individuals with recessive dystrophic epidermolysis bullosa. WOUND REPAIR REGEN vol. 15, (6) A114-A114.
Pourreyron C, Cox G, Mao X, Volz A, Baksh N, Wong T, Fassihi H, Arita K et al.(2007). Patients with recessive dystrophic epidermolysis bullosa develop squamous-cell carcinoma regardless of type VII collagen expression. J Invest Dermatol vol. 127, (10) 2438-2444.
10.1038/sj.jid.5700878
Myers SR, Leigh IM, Navsaria H(2007). Epidermal repair results from activation of follicular and epidermal progenitor keratinocytes mediated by a growth factor cascade. Wound Repair Regen vol. 15, (5) 693-701.
10.1111/j.1524-475X.2007.00297.x
Kelsell DP, HARWOOD CA, Leigh IM, Proby CM, Purdie KJ, Teh MT, Lambert SR, Young BD et al.(2007). Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis. Genes Chromosomes Cancer vol. 46, 661-669.
Purdie KJ, Lambert SR, Teh M-T, Chaplin T, Molloy G, Raghavan M, Kelsell DP, Leigh IM et al.(2007). Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis. Genes Chromosomes Cancer vol. 46, (7) 661-669.
10.1002/gcc.20447
Cox GA, Pourreyron C, Volz A, O'Toole EA, Chen M, Bruckner-Tuderman L, Salas-Alanis JC, Leigh IM et al. (2007). Does the presence or absence of type VII collagen expression in individuals with recessive dystrophic epidermolysis bullosa have implications for the risk of developing squamous cell carcinoma?. BRITISH JOURNAL OF DERMATOLOGY. vol. 157, 12-13.
Purdie K, Lambert S, Teh M, Chaplin T, Molloy G, Raghavan M, Kelsell DP, Leigh IM et al. (2007). Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis. BRITISH JOURNAL OF DERMATOLOGY. vol. 156, 1100-1101.
Mao X, Pourreyron C, Purdie K, Holder MV, Baksh N, Wong T, Fassihi H, Volz A et al. (2007). Identification of the molecular signatures in cutaneous squamous cell carcinoma excised from patients with recessive dystrophic epidermolysis bullosa by using integrated genomic techniques. BRITISH JOURNAL OF DERMATOLOGY. vol. 156, 1110-1110.
Wong T, Gammon L, Liu L, Ozoemena L, Dopping-Hepenstal PJC, Jones C, Leigh IM, Navsaria H et al. (2007). Intradermal injection of allogeneic normal human broblasts promotes type VII collagen deposition at the dermal-epidermal junction in individuals with recessive dystrophic epidermolysis bullosa. BRITISH JOURNAL OF DERMATOLOGY. vol. 156, 1096-1096.
Ekeowa-Anderson AL, Harwood CA, Perrett CM, Sahota A, Annan H, Ran H, Leigh IM, Gibbon KL(2007). Vulval intraepithelial neoplasia and periungual Bowen's disease concordant for mucosal (HPV-34) and epidermodysplasia verruciformis (HPV-21) human papillomavirus types. CLIN EXP DERMATOL vol. 32, (3) 304-307.
10.1111/j.1365-2230.2007.02388.x
Teh MT, Blaydon D, Ghali LR, Briggs V, Edmunds S, Pantazi E, Barnes MR, Leigh IM et al.(2007). Erratum: Role for WNT16B in human epidermal keratinocyte proliferation and differentiation (Journal of Cell Science vol. 120 (330-339)). Journal of Cell Science vol. 120, (5)
10.1242/jcs.03421
Teh MT, Blaydon D, Ghali LR, Briggs V, Edmunds S, Pantazi E, Barnes MR, Leigh IM et al.(2007). Role for WNT16B in human epidermal keratinocyte proliferation and differentiation (vol 120, pg 330, 2007). J CELL SCI vol. 120, (5) 917-917.
10.1242/jcs.03329
Perrett CM, McGregor JM, Warwick J, Karran P, Leigh IM, Proby CM, Harwood CA(2007). Treatment of post-transplant premalignant skin disease: a randomized intrapatient comparative study of 5-fluorouracil cream and topical photodynamic therapy. Br J Dermatol vol. 156, (2) 320-328.
10.1111/j.1365-2133.2006.07616.x
Teh M-T, Blaydon D, Ghali LR, Briggs V, Edmunds S, Pantazi E, Barnes MR, Leigh IM et al.(2007). Role for WNT16B in human epidermal keratinocyte proliferation and differentiation. J Cell Sci vol. 120, (Pt 2) 330-339.
10.1242/jcs.03329
McMillan JR, Akiyama M, Rouan F, Mellerio JE, Lane EB, Leigh IM, Owaribe K, Wiche G et al.(2007). Plectin defects in epidermolysis bullosa simplex with muscular dystrophy. MUSCLE NERVE vol. 35, (1) 24-35.
10.1002/mus.20655
Price RD, Das-Gupta V, Leigh IM, Navsaria HA(2006). A comparison of tissue-engineered hyaluronic acid dermal matrices in a human wound model. Tissue Eng vol. 12, (10) 2985-2995.
10.1089/ten.2006.12.2985
Purdie K, Lambert S, Harwood C, Teh T, Kelsell D, Young B, Leigh I, Proby C (2006). Allelic imbalances and chromosome 9p microdeletion demonstrated in cutaneous squamous cell carcinomas using single nucleotide polymorphism microarray analysis. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 126, 87-87.
Sinclair C, O'Toole E, Leigh I, Paige D, Elbashir H, Stevens H, Booy R, Mein C et al. (2006). Filaggrin mutation is not a genetic risk factor for atopic dermatitis in the Bangladeshi population. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 126, 40-40.
Wong T, Gammon L, Liu L, Ozoemena L, Dopping-Hepenstal PJ, Jones C, Leigh IM, Navsaria H et al. (2006). Intradermal injection of allogeneic human fibroblasts promotes type VII collagen deposition at the dermal-epidermal junction in recessive dystrophic epidermolysis bullosa. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 126, 32-32.
Pourreyron C, Jones C, Volz A, O'Toole EA, Chen M, Hart IR, Bruckner-Tuderman L, Salis-Alanis JC et al. (2006). Patients with recessive dystrophic epidermolysis bullosa develop squamous cell carcinoma regardless of type VII collagen NC1 domain expression. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 126, 32-32.
Norgett EE, Lucke TW, Bowers B, Munro CS, Leigh IM, Kelsell DP(2006). Early death from cardiomyopathy in a family with autosomal dominant striate palmoplantar keratoderma and woolly hair associated with a novel insertion mutation in desmoplakin. J Invest Dermatol vol. 126, (7) 1651-1654.
10.1038/sj.jid.5700291
Green J, Ikram M, Vyas J, Patel N, Proby CM, Ghali L, Leigh IM, O'Toole EA et al.(2006). Overexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumours. Br J Cancer vol. 94, (10) 1446-1451.
10.1038/sj.bjc.6603135
https://qmro.qmul.ac.uk/xmlui/handle/123456789/17992
Purdie K, Teh M, Harwood C, Young B, Proby C, Leigh I (2006). Allelic imbalances and chromosome 9p microdeletion demonstrated in cutaneous squamous cell carcinomas using single nucleotide polymorphism microarray analysis. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 126, 18-18.
Harwood CA, Proby CM, McGregor JM, Sheaff MT, Leigh IM, Cerio R(2006). Clinicopathologic features of skin cancer in organ transplant recipients: a retrospective case-control series. J Am Acad Dermatol vol. 54, (2) 290-300.
10.1016/j.jaad.2005.10.049
Uzumcu A, Norgett EE, Dindar A, Uyguner O, Nisli K, Kayserili H, Sahin SE, Dupont E et al.(2006). Loss of desmoplakin isoform I causes early onset cardiomyopathy and heart failure in a Naxos-like syndrome. J Med Genet vol. 43, (2)
10.1136/jmg.2005.032904
Common JEA, O'Toole EA, Leigh IM, Thomas A, Griffiths WAD, Venning V, Grabczynska S, Peris Z et al.(2005). Clinical and genetic heterogeneity of erythrokeratoderma variabilis. J Invest Dermatol vol. 125, (5) 920-927.
10.1111/j.0022-202X.2005.23919.x
Leigh IM(2005). Genetic diseases affecting the epidermis. Exp Dermatol vol. 14, (10) 792-793.
10.1111/j.1600-0625.2005.0355i.x
Alam NA, Olpin S, Rowan A, Kelsell D, Leigh IM, Tomlinson IPM, Weaver T(2005). Missense mutations in fumarate hydratase in multiple cutaneous and uterine leiomyomatosis and renal cell cancer. J Mol Diagn vol. 7, (4) 437-443.
10.1016/S1525-1578(10)60574-0
Kelsell DP, Norgett EE, Unsworth H, Teh MT, Cullup T, Mein CA, Dopping-Hepenstal PJ, Kennedy CT et al. (2005). Clinical and molecular features of Harlequin ichthyosis. BRITISH JOURNAL OF DERMATOLOGY. vol. 153, 5-5.
Giehl KA, Dean D, Dawber RPR, Leigh I, de Berker DAR, Wojnarowska F(2005). Cytokeratin expression in pili annulati hair follicles. CLIN EXP DERMATOL vol. 30, (4) 426-428.
10.1111/j.1365-2230.2005.01812.x
Alam NA, Olpin S, Leigh IM(2005). Fumarate hydratase mutations and predisposition to cutaneous leiomyomas, uterine leiomyomas and renal cancer. BRIT J DERMATOL vol. 153, (1) 11-17.
10.1111/j.1365-2133.2005.06678.x
Harwood CA, Ismail F, Leedham-Green M, Leigh IM, Proby CM (2005). Low-dose retinoids in the prevention of cutaneous squamous cell carcinomas in organ-transplant recipients: a 16-year retrospective study. BRITISH JOURNAL OF DERMATOLOGY. vol. 153, 3-4.
Kelsell DP, Norgett EE, Unsworth H, Teh M-T, Cullup T, Mein CA, Dopping-Hepenstal PJ, Dale BA et al.(2005). Mutations in ABCA12 underlie the severe congenital skin disease harlequin ichthyosis. Am J Hum Genet vol. 76, (5) 794-803.
10.1086/429844
Fitchett CJ, Rugg EL, Gilfillan N, Leigh IM, O'Toole EA (2005). Functional effects of pachyonychia congenita type I mutations on keratinocyte migration and proliferation. BRITISH JOURNAL OF DERMATOLOGY. vol. 152, 835-835.
Fitchett CJ, Rugg EL, Gilfillan N, Leigh IM, O'Toole EA (2005). Functional effects of pachyonychia congenital type I mutations on keratinocyte motility and proliferation. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 124, A95-A95.
Purdie K, Surentheran T, Sterling J, Bell L, McGregor J, Proby C, Harwood C, Leigh I et al. (2005). Human papillomavirus gene expression in cutaneous squamous cell carcinomas from immunosuppressed and immunocompetent individuals. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 124, A125-A125.
Harwood CA, Leedham-Green M, Leigh IM, Proby CM(2005). Low-dose retinoids in the prevention of cutaneous squamous cell carcinomas in organ transplant recipients: a 16-year retrospective study. Arch Dermatol vol. 141, (4) 456-464.
10.1001/archderm.141.4.456
Alam NA, Olpin S, Rowan A, Kelsell D, Leigh IM, Tomlinson IPM, Weaver T (2005). Missense FH mutations in multiple cutaneous and uterine leiomyomatosis and renal cell cancer. BRITISH JOURNAL OF DERMATOLOGY. vol. 152, 845-845.
Kelsell DP, Norgett E, Unsworth H, Teh M, Cullop T, Dale B, Leigh IM, Eady RA et al. (2005). Mutations in ABCA12 underlie harlequin ichthyosis. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 124, A75-A75.
Alam NA, Barclay E, Rowan AJ, Tyrer JP, Calonje E, Manek S, Kelsell D, Leigh I et al.(2005). Clinical features of multiple cutaneous and uterine leiomyomatosis: an underdiagnosed tumor syndrome. Arch Dermatol vol. 141, (2) 199-206.
10.1001/archderm.141.2.199
Harwood CA, Perrett CM, Brown VL, Leigh IM, McGregor JM, Proby CM(2005). Imiquimod cream 5% for recalcitrant cutaneous warts in immunosuppressed individuals. Br J Dermatol vol. 152, (1) 122-129.
10.1111/j.1365-2133.2005.06322.x
Price RD, Myers S, Leigh IM, Navsaria HA(2005). The role of hyaluronic acid in wound healing: assessment of clinical evidence. Am J Clin Dermatol vol. 6, (6) 393-402.
10.2165/00128071-200506060-00006
Rugg EL, Leigh IM(2004). The keratins and their disorders. AM J MED GENET C vol. 131C, (1) 4-11.
10.1002/ajmg.c.30029
Gaspar HB, Harwood C, Leigh I, Thrasher AJ(2004). Severe cutaneous papillomavirus disease after haematopoietic stem-cell transplantation in patients with severe combined immunodeficiency. BRIT J HAEMATOL vol. 127, (2) 232-233.
10.1111/j.1365-2141.2004.05176.x
Norgett EE, Wolf F, Balme B, Leigh IM, Perrot H, Kelsell DP, Haftek M(2004). Hereditary 'white nails': a genetic and structural study. Br J Dermatol vol. 151, (1) 65-72.
10.1111/j.1365-2133.2004.05994.x
Hubbard VG, Breuer J, Leigh IM, Thrasher A, Harwood CA (2004). Viral warts following bone marrow transplantation for severe combined immunodeficiency harbour potentially oncogenic human papillomavirus types. BRITISH JOURNAL OF DERMATOLOGY. vol. 151, 19-19.
Harwood CA, Surentheran T, Sasieni P, Proby CM, Bordea C, Leigh IM, Wojnarowska F, Breuer J et al.(2004). Increased risk of skin cancer associated with the presence of epidermodysplasia verruciformis human papillomavirus types in normal skin. Br J Dermatol vol. 150, (5) 949-957.
10.1111/j.1365-2133.2004.05847.x
Langan JE, Cole CG, Huckle EJ, Byrne S, McRonald FE, Rowbottom L, Ellis A, Shaw JM et al.(2004). Novel microsatellite markers and single nucleotide polymorphisms refine the tylosis with oesophageal cancer (TOC) minimal region on 17q25 to 42.5 kb: sequencing does not identify the causative gene. Hum Genet vol. 114, (6) 534-540.
10.1007/s00439-004-1100-3
Price RD, Das-Gupta V, Harris PA, Leigh IM, Navsaria HA(2004). The role of allogenic fibroblasts in an acute wound healing model. Plast Reconstr Surg vol. 113, (6) 1719-1729.
10.1097/01.prs.0000117367.86893.ce
Waseem A, Karsten U, Leigh IM, Purkis P, Waseem NH, Lane EB(2004). Conformational changes in the rod domain of human keratin 8 following heterotypic association with keratin 18 and its implication for filament stability. Biochemistry vol. 43, (5) 1283-1295.
10.1021/bi035072s
Ghali L, Wong S-T, Tidman N, Quinn A, Philpott MP, Leigh IM(2004). Epidermal and hair follicle progenitor cells express melanoma-associated chondroitin sulfate proteoglycan core protein. J Invest Dermatol vol. 122, (2) 433-442.
10.1046/j.0022-202X.2004.22207.x
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Morley SM, D'Alessandro M, Sexton C, Rugg EL, Navsaria H, Shemanko CS, Huber M, Hohl D et al.(2003). Generation and characterization of epidermolysis bullosa simplex cell lines: scratch assays show faster migration with disruptive keratin mutations. BRIT J DERMATOL vol. 149, (1) 46-58.
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Hubbard VG, Leigh IM, Zakrzewska JM (2003). Use of hydroxychloroquine in the treatment of oral and vulvovaginal lichen planus - a retrospective pilot study. BRITISH JOURNAL OF DERMATOLOGY. vol. 149, 54-54.
Alam NA, Rowan AJ, Wortham NC, Pollard PJ, Mitchell M, Tyrer JP, Barclay E, Calonje E et al.(2003). Genetic and functional analyses of FH mutations in multiple cutaneous and uterine leiomyomatosis, hereditary leiomyomatosis and renal cancer, and fumarate hydratase deficiency. HUM MOL GENET vol. 12, (11) 1241-1252.
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Bloor BK, Tidman N, Leigh IM, Odell E, Dogan B, Wollina U, Ghali L, Waseem A(2003). Expression of keratin K2e in cutaneous and oral lesions: association with keratinocyte activation, proliferation, and keratinization. Am J Pathol vol. 162, (3) 963-975.
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Orteu CH, Buchanan JA, Hutchison I, Leigh IM, Bull RH(2001). Systemic lupus erythematosus presenting with oral mucosal lesions: easily missed?. Br J Dermatol vol. 144, (6) 1219-1223.
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Sampson JH, Raman A, Karlsen G, Navsaria H, Leigh IM(2001). In vitro keratinocyte antiproliferant effect of Centella asiatica extract and triterpenoid saponins. Phytomedicine vol. 8, (3) 230-235.
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Hatsell SJ, Eady RA, Wennerstrand L, Dopping-Hepenstal P, Leigh IM, Munro C, Kelsell DP(2001). Novel splice site mutation in keratin 1 underlies mild epidermolytic palmoplantar keratoderma in three kindreds. J Invest Dermatol vol. 116, (4) 606-609.
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Ola A, Waga S, Ellison V, Stillman B, McGurk M, Leigh IM, Waseem NH, Waseem A(2001). Human-Saccharomyces cerevisiae proliferating cell nuclear antigen hybrids: oligomeric structure and functional characterization using in vitro DNA replication. J Biol Chem vol. 276, (13) 10168-10177.
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Ishida-Yamamoto A, Kelsell D, Common J, Houseman MJ, Hashimoto M, Shibaki H, Asano K, Takahashi H et al.(2000). A case of erythrokeratoderma variabilis without mutations in connexin 31. BRIT J DERMATOL vol. 143, (6) 1283-1287.
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Popp S, Waltering S, Holtgreve-Grez H, Jauch A, Proby C, Leigh IM, Boukamp P(2000). Genetic characterization of a human skin carcinoma progression model: from primary tumor to metastasis. J INVEST DERMATOL vol. 115, (6) 1095-1103.
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Kelsell DP, Norgett EE, Hatsell SJ, Common JEA, Cabezas JCR, Stevens HP, Carvajal-Huerta L, Leigh IM(2000). Recessive mutation in desmoplakin disrupts desmoplakin/intermediate filament interactions and causes dilated cardiomyopathy, woolly hair and keratoderma. J INVEST DERMATOL vol. 115, (6) 1170-1170.
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