Publications: Prof Nicholas Lemoine

McNeish IA, Tenev T, Bell S, Marani M, Vassaux G, Lemoine N ( 2024 ) . Editorial Expression of Concern: Herpes simplex virus thymidine kinase/ganciclovir–induced cell death is enhanced by co-expression of caspase-3 in ovarian carcinoma cells . Cancer Gene Therapy vol. 31 , ( 6 ) 955 - 955 .

Miao T, Symonds A, Hickman OJ, Wu D, Wang P, Lemoine N, Wang Y, Linardopoulos S et al. ( 2024 ) . Inhibition of Bromodomain Proteins Enhances Oncolytic HAdVC5 Replication and Efficacy in Pancreatic Ductal Adenocarcinoma (PDAC) Models . International Journal of Molecular Sciences vol. 25 , ( 2 )

Yan W, Dunmall LSC, Lemoine NR, Wang Y, Wang Y, Wang P ( 2023 ) . The capability of heterogeneous γδ T cells in cancer treatment . Frontiers in Immunology vol. 14 ,

Zhou W, Miao J, Cheng Z, Wang Z, Wang J, Guo H, Wang P, Lu S et al. ( 2023 ) . Hypoxia-regulated secretion of IL-12 enhances antitumor activity and safety of CD19 CAR-T cells in the treatment of DLBCL . Molecular Therapy Oncology vol. 30 , 216 - 226 .

Baleeiro RB, Liu P, Dunmall LSC, Di Gioia C, Nagano A, Cutmore L, Wang J, Chelala C et al. ( 2023 ) . Personalized neoantigen viro-immunotherapy platform for triple-negative breast cancer . Journal for ImmunoTherapy of Cancer vol. 11 , ( 8 )

Wang L, Wang X, Wu Y, Wang J, Zhou W, Wang J, Guo H, Zhang N et al. ( 2023 ) . A novel microenvironment regulated system CAR-T (MRS.CAR-T) for immunotherapeutic treatment of esophageal squamous carcinoma . Cancer Letters vol. 568 ,

Lemoine NR ( 2023 ) . Preface . Understanding Gene Therapyxvii - xvii .

Lemoine NR ( 2023 ) . Understanding gene therapy .

Lemoine NR ( 2023 ) . Prospects for gene therapy . Understanding Gene Therapy , Taylor & Francis

Jia Y, Wang Y, Dunmall LSC, Lemoine NR, Wang P, Wang Y ( 2023 ) . Syrian hamster as an ideal animal model for evaluation of cancer immunotherapy . Frontiers in Immunology vol. 14 ,

Wang L, Wu Y, Wang X, Wang J, Zhou W, Wang J, Guo H, Wu Y et al. ( 2023 ) . A Novel Microenvironment Regulated System CAR-T (MRS.CAR-T) for Immunotherapeutic Treatment of Esophageal Squamous Carcinoma . MOLECULAR THERAPY . vol. 31 , 645 - 646 .

Baleeiro R, Liu P, Chard LS, Di Gioia C, Nagano A, Cutmore L, Wang J, Chelala C et al. ( 2023 ) . Emerging Data from the Use of TILT-123, an Oncolytic Adenovirus Armed with TNFa and IL-2 in Patients with Solid Tumors . MOLECULAR THERAPY . vol. 31 , 154 - 154 .

Wong HH, Jiang G, Gangeswaran R, Wang P, Wang J, Yuan M, Wang H, Bhakta V et al. ( 2022 ) . Modification of the Early Gene Enhancer-promoter Improves the Oncolytic Potency of Adenovirus 11 . Molecular Therapy vol. 31 , ( 1 )

Bliss J, Brown J, Chalmers A, Lemoine N, Murphy G, Wydenbach K, Frame I ( 2022 ) . Now is Our Opportunity to Revolutionise Cancer Clinical Trials . Clinical Oncology vol. 35 , ( 3 ) 139 - 142 .

Sun Y, Zhang Z, Zhang C, Zhang N, Wang P, Chu Y, Dunmall LSC, Lemoine NR et al. ( 2022 ) . An effective therapeutic regime for treatment of glioma using oncolytic vaccinia virus expressing IL-21 in combination with immune checkpoint inhibition . Molecular Therapy Oncology vol. 26 , 105 - 119 .

Baleeiro RB, Bouwens CJ, Liu P, Di Gioia C, Dunmall LSC, Nagano A, Gangeswaran R, Chelala C et al. ( 2022 ) . MHC class II molecules on pancreatic cancer cells indicate a potential for neo-antigen-based immunotherapy . OncoImmunology vol. 11 , ( 1 )

Baleeiro RB, Dunmall LSC, Liu P, Lu S, Lone Y, Lemoine NR, Wang Y ( 2022 ) . Optimized Anchor-Modified Peptides Targeting Mutated RAS Are Promising Candidates for Immunotherapy . Frontiers in Immunology vol. 13 ,

Cao D, Song Q, Li J, Dunmall LSC, Jiang Y, Qin B, Wang J, Guo H et al. ( 2022 ) . Redirecting anti-Vaccinia virus T cell immunity for cancer treatment by AAV-mediated delivery of the VV B8R gene . Molecular Therapy Oncology vol. 25 , 264 - 275 .

Lu S, Zhang Z, Du P, Chard LS, Yan W, El Khouri M, Wang Z, Zhang Z et al. ( 2021 ) . Correction: A Virus-infected, Reprogrammed Somatic Cell–derived Tumor Cell (VIReST) Vaccination Regime can Prevent Initiation and Progression of Pancreatic Cancer . Clinical Cancer Research vol. 27 , ( 9 ) 2663 - 2663 .

Zhang Z, Zhang C, Miao J, Wang Z, Wang Z, Cheng Z, Wang P, Dunmall LSC et al. ( 2020 ) . A Tumor-Targeted Replicating Oncolytic Adenovirus Ad-TD-nsIL12 as a Promising Therapeutic Agent for Human Esophageal Squamous Cell Carcinoma . Cells vol. 9 , ( 11 )

Martin L-A, Lemoine NR ( 2020 ) . Cancer gene therapy I: genetic intervention strategies . Gene Therapy , Taylor & Francis

Gadaleta E, Fourgoux P, Pirró S, Thorn GJ, Nelan R, Ironside A, Rajeeve V, Cutillas PR et al. ( 2020 ) . Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer . npj Breast Cancer vol. 6 , ( 1 )

Gadaleta E, Fourgoux P, Pirró S, Thorn GJ, Nelan R, Ironside A, Rajeeve V, Cutillas PR et al. ( 2020 ) . Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer . NPJ Breast Cancer vol. 6 , ( 1 )

Zhang Z, Lu S, Dunmall LSC, Wang Z, Cheng Z, Zhang Z, Yan W, Chu Y et al. ( 2020 ) . Treatment and Prevention of Lung Cancer Using a Virus-Infected Reprogrammed Somatic Cell-Derived Tumor Cell Vaccination (VIReST) Regime . Frontiers in Immunology vol. 11 ,

Oscanoa J, Sivapalan L, Gadaleta E, Ullah AZD, Lemoine NR, Chelala C ( 2020 ) . SNPnexus: a web server for functional annotation of human genome sequence variation (2020 update) . Nucleic Acids Research vol. 48 , ( W1 ) w185 - w192 .

( 2020 ) . Correction: A new oncolytic Vaccinia virus augments antitumor immune responses to prevent tumor recurrence and metastasis after surgery . Journal for ImmunoTherapy of Cancer vol. 8 , ( 1 )

Ahmed J, Chard LS, Yuan M, Wang J, Howells A, Li Y, Li H, Zhang Z et al. ( 2020 ) . A new oncolytic Vaccinia virus augments antitumor immune responses to prevent tumor recurrence and metastasis after surgery . Journal for ImmunoTherapy of Cancer vol. 8 , ( 1 )

Ferguson MS, Chard Dunmall LS, Gangeswaran R, Marelli G, Tysome JR, Burns E, Whitehead MA, Aksoy E et al. ( 2020 ) . Transient Inhibition of PI3Kδ Enhances the Therapeutic Effect of Intravenous Delivery of Oncolytic Vaccinia Virus . Molecular Therapy vol. 28 , ( 5 ) 1263 - 1275 .

Cutmore LC, Brown NF, Raj D, Chauduri S, Wang P, Maher J, Wang Y, Lemoine NR et al. ( 2020 ) . Pancreatic Cancer UK Grand Challenge: Developments and challenges for effective CAR T cell therapy for pancreatic ductal adenocarcinoma . Pancreatology

Lu S, Zhang Z, Du P, Chard LS, Yan W, Khouri ME, Wang Z, Zhang Z et al. ( 2020 ) . A Virus-Infected, Reprogrammed Somatic Cell–Derived Tumor Cell (VIReST) Vaccination Regime Can Prevent Initiation and Progression of Pancreatic Cancer . Clinical Cancer Research vol. 26 , ( 2 ) 465 - 476 .

Ottaviani S, Stebbing J, Frampton AE, Zagorac S, Krell J, de Giorgio A, Trabulo SM, Nguyen VTM et al. ( 2019 ) . Author Correction: TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression . Nat Commun vol. 10 , ( 1 ) 3738 - 3738 .

Hallden G, Wang Y, Wong H-H, Lemoine NR ( 2019 ) . ONCOLYTIC ADENOVIRUSES FOR CANCER GENE THERAPY . Advanced Textbook on Gene Transfer, Gene Therapy and Genetic Pharmacology , World Scientific Publishing

( 2019 ) . Erratum . International Journal of Cancer vol. 144 , ( 10 ) e6 - e6 .

Foxler DE, Bridge KS, Foster JG, Grevitt P, Curry S, Shah KM, Davidson KM, Nagano A et al. ( 2018 ) . A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia . EMBO Mol Med

Ullah AZD, Oscanoa J, Wang J, Nagano A, Lemoine NR, Chelala C ( 2018 ) . SNPnexus: assessing the functional relevance of genetic variation to facilitate the promise of precision medicine . Nucleic Acids Research vol. 46 , ( W1 ) w109 - w113 .

Ottaviani S, Stebbing J, Frampton AE, Zagorac S, Krell J, de Giorgio A, Trabulo SM, Nguyen VTM et al. ( 2018 ) . TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression . Nature Communications vol. 9 , ( 1 )

Marelli G, Howells A, Lemoine NR, Wang Y ( 2018 ) . Oncolytic Viral Therapy and the Immune System: A Double-Edged Sword Against Cancer . Frontiers in Immunology vol. 9 , 866 - 866 .

Wang P, Li X, Wang J, Gao D, Li Y, Li H, Chu Y, Zhang Z et al. ( 2018 ) . Author Correction: Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent . Nature Communications vol. 9 , ( 1 )

Chinswangwatanakul V, Worthington T, Lemoine NR, Williamson RC, Kakkar AK ( 2017 ) . Circulating Vascular Endothelial Growth Factor Correlates with Systemic Thrombin Generation in Patients with Pancreatic Carcinoma . Thrombosis and Haemostasis vol. 81 , ( 05 ) 851 - 851 .

Wang P, Li X, Wang J, Gao D, Li Y, Li H, Chu Y, Zhang Z et al. ( 2017 ) . Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent . Nat Commun vol. 8 , ( 1 ) 1395 - 1395 .

Marzec J, Dayem Ullah AZ, Pirrò S, Gadaleta E, Crnogorac-Jurcevic T, Lemoine NR, Kocher HM, Chelala C ( 2017 ) . The Pancreatic Expression Database: 2018 update . Nucleic Acids Res vol. 46 , ( D1 ) D1107 - D1110 .

Glorioso JC, Lemoine N ( 2017 ) . Gene therapy—from small beginnings to where we are now . Gene Therapy vol. 24 , ( 9 ) 495 - 496 .

Spurrell E, Gangeswaran R, Wang P, Cao F, Gao D, Feng B, Wold W, Tollefson A et al. ( 2017 ) . Correction for Spurrell et al., “STAT1 Interaction with E3-14.7K in Monocytes Affects the Efficacy of Oncolytic Adenovirus” . Journal of Virology vol. 91 , ( 20 ) 10.1128/jvi.00670 - 10.1128/jvi.00617 .

Howells A, Marelli G, Lemoine NR, Wang Y ( 2017 ) . Oncolytic Viruses-Interaction of Virus and Tumor Cells in the Battle to Eliminate Cancer . Front Oncol vol. 7 , 195 - 195 .

Sangaralingam A, Dayem Ullah AZ, Marzec J, Gadaleta E, Nagano A, Ross-Adams H, Wang J, Lemoine NR et al. ( 2017 ) . 'Multi-omic' data analysis using O-miner . Brief Bioinform

Tysome JR, Alusi G, Lemoine N, Wang Y ( 2017 ) . Oncolytic Vaccinia Virus Gene Therapy for HNSCC . Otolaryngology vol. 139 , ( S2 ) p92 - p93 .

Wang J, Dumartin L, Mafficini A, Ulug P, Sangaralingam A, Alamiry NA, Radon TP, Salvia R et al. ( 2017 ) . Splice variants as novel targets in pancreatic ductal adenocarcinoma . Scientific Reports vol. 7 , ( 1 )

Webb ES, Liu P, BALEEIRO R, Lemoine NR, Yuan M, Wang Y ( 2017 ) . Immune checkpoint inhibitors in cancer therapy . Journal of Biomedical Research

Szlosarek PW, Steele JP, Nolan L, Gilligan D, Taylor P, Spicer J, Lind M, Mitra S et al. ( 2017 ) . Arginine Deprivation With Pegylated Arginine Deiminase in Patients With Argininosuccinate Synthetase 1–Deficient Malignant Pleural Mesothelioma: A Randomized Clinical Trial . JAMA Oncology vol. 3 , ( 1 ) 58 - 66 .

Szlosarek PW, Steele JP, Nolan L, Gilligan D, Taylor P, Spicer J, Lind M, Mitra S et al. ( 2017 ) . Arginine deprivation with pegylated arginine deiminase in patients with argininosuccinate synthetase 1-deficient malignant pleural mesothelioma a randomized clinical trial . JAMA Oncology vol. 3 , ( 1 ) E1 - E9 .

CRNOGORAC-JURCEVIC T, Dumartin L, Alrawashdeh W, Trabulo SM, Radon TP, Steiger K, Feakins RM, di Magliano MP et al. ( 2016 ) . ER stress protein AGR2 precedes and is involved in the regulation of pancreatic cancer initiation . Oncogene

Yuan M, Wang P, Chard LS, Lemoine NR, Wang Y ( 2016 ) . A Simple and Efficient Approach to Construct Mutant Vaccinia Virus Vectors . Journal of Visualized Experiments ( 116 )

Carapuça EF, Gemenetzidis E, Feig C, Bapiro TE, Williams MD, Wilson AS, Delvecchio FR, Arumugam P et al. ( 2016 ) . Anti-stromal treatment together with chemotherapy targets multiple signalling pathways in pancreatic adenocarcinoma . Journal of Pathology vol. 239 , ( 3 ) 286 - 296 .

Yuan M, Webb E, Lemoine NR, Wang Y ( 2016 ) . CRISPR-Cas9 as a Powerful Tool for Efficient Creation of Oncolytic Viruses . Viruses vol. 8 , ( 3 )

Pantelidou C, Cherubini G, Lemoine NR, Halldén G ( 2016 ) . The E1B19K-deleted oncolytic adenovirus mutant AdΔ19K sensitizes pancreatic cancer cells to drug-induced DNA-damage by down-regulating Claspin and Mre11 . Oncotarget vol. 7 , ( 13 ) 15703 - 15724 .

Al Yaghchi C, Zhang Z, Alusi G, Lemoine NR, Wang Y ( 2015 ) . Vaccinia virus, a promising new therapeutic agent for pancreatic cancer . Immunotherapy vol. 7 , ( 12 ) 1249 - 1258 .

Ibrahim AM, Wang Y, Lemoine NR ( 2015 ) . Immune-checkpoint blockade: the springboard for immuno-combination therapy . Gene Therapy vol. 22 , ( 11 ) 849 - 850 .

Yuan M, Gao X, Chard LS, Ali Z, Ahmed J, Li Y, Liu P, Lemoine NR et al. ( 2015 ) . A marker-free system for highly efficient construction of vaccinia virus vectors using CRISPR Cas9 . Molecular Therapy — Methods & Clinical Development vol. 2 ,

Radon TP, Massat NJ, Jones R, Alrawashdeh W, Dumartin L, Ennis D, Duffy SW, Kocher HM et al. ( 2015 ) . Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma . Clinical Cancer Research vol. 21 , ( 15 ) 3512 - 3521 .

Chard LS, Lemoine NR, Wang Y ( 2015 ) . New role of Interleukin-10 in enhancing the antitumor efficacy of oncolytic vaccinia virus for treatment of pancreatic cancer . OncoImmunology vol. 4 , ( 9 )

Hughes J, Wang P, Alusi G, Shi H, Chu Y, Wang J, Bhakta V, McNeish I et al. ( 2015 ) . Lister strain vaccinia virus with thymidine kinase gene deletion is a tractable platform for development of a new generation of oncolytic virus . Gene Therapy vol. 22 , ( 6 ) 476 - 484 .

Ahmed J, Yuan M, Li Y, Chu Y, Zhang Z, Gao D, Chard LS, Alusi G et al. ( 2015 ) . 420. A Promising Neo-Adjuvant Immuno-Therapeutic Agent for Preventing Cancer Recurrence and Metastasis After Surgery . Molecular Therapy . vol. 23 ,

Ferguson M, Tysome J, Burns E, Whitehead M, Aksoy E, Clear A, Alusi G, Hiley C et al. ( 2015 ) . 649. Targeting Innate Host Immunity Through PI3K Delta for Enhancement of Systemic Delivery of Oncolytic Vaccinia Virus . Molecular Therapy . vol. 23 , s258 - s259 .

Hughes J, Wang P, Alusi G, Shi H, Chu Y, Wang J, Bhakta V, McNeish I et al. ( 2015 ) . Lister strain vaccinia virus with thymidine kinase gene deletion is a tractable platform for development of a new generation of oncolytic virus . Gene Therapy vol. 22 , ( 6 ) 476 - 484 .

Yuan M, Zhang W, Wang J, Al Yaghchi C, Ahmed J, Chard L, Lemoine NR, Wang Y ( 2015 ) . Efficiently Editing the Vaccinia Virus Genome by Using the CRISPR-Cas9 System . Journal of Virology vol. 89 , ( 9 ) 5176 - 5179 .

Chard LS, Maniati E, Wang P, Zhang Z, Gao D, Wang J, Cao F, Ahmed J et al. ( 2015 ) . A Vaccinia Virus Armed with Interleukin-10 Is a Promising Therapeutic Agent for Treatment of Murine Pancreatic Cancer . Clinical Cancer Research vol. 21 , ( 2 ) 405 - 416 .

Haider S, Wang J, Nagano A, Desai A, Arumugam P, Dumartin L, Fitzgibbon J, Hagemann T et al. ( 2014 ) . A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma . Genome Medicine vol. 6 , ( 12 )

Hiley CT, Chard L, Tysome J, Briat A, Lemoine NR, Wang Y ( 2012 ) . Abstract A37: Increased efficacy of oncolytic vaccinia virus, an emerging therapy for pancreatic adenocarcinoma, due to intratumoral hypoxia and vascular endothelial growth factor A . Conference: Therapya37 - a37 .

Coleman SJ, Chioni A-M, Ghallab M, Anderson RK, Lemoine NR, Kocher HM, Grose RP ( 2014 ) . Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells facilitates pancreatic cancer cell invasion . EMBO Mol Med vol. 6 , ( 4 ) 467 - 481 .

Coleman S, Chioni A-M, Ghallab M, Anderson R, Lemoine N, Kocher H, Grose R ( 2014 ) . Nuclear FGFR signalling as a driving force in pancreatic cancer . Pancreatology vol. 14 , ( 2 )

Allen MD, Luong P, Hudson C, Leyton J, Delage B, Ghazaly E, Cutts R, Yuan M et al. ( 2014 ) . Prognostic and therapeutic impact of argininosuccinate synthetase 1 control in bladder cancer as monitored longitudinally by PET imaging . Cancer Res vol. 74 , ( 3 ) 896 - 907 .

Spurrell E, Gangeswaran R, Wang P, Cao F, Gao D, Feng B, Wold W, Tollefson A et al. ( 2014 ) . STAT1 interaction with E3-14.7K in monocytes affects the efficacy of oncolytic adenovirus . J Virol vol. 88 , ( 4 ) 2291 - 2300 .

Hallden G, Wang Y, Wong H-H, Lemoine NR ( 2014 ) . 18: ONCOLYTIC ADENOVIRUSES FOR CANCER GENE THERAPY . Advanced Textbook on Gene Transfer, Gene Therapy and Genetic Pharmacology , vol. 1 , World Scientific Publishing

Ahmed J, Yuan M, Li Y, Chu Y, Shi H, Chard L, Alusi G, Lemoine N et al. ( 2014 ) . A Novel Tumour Selective Oncolytic Vaccinia Virus Lacking the N1L Gene Enhances the Anti-Tumour Immune Response When Used as an Anticancer Therapeutic . MOLECULAR THERAPY . vol. 22 , S248 - S249 .

Pantelidou C, Lemoine N, Hallden G ( 2014 ) . Adenoviruses deleted in the anti-apoptotic E1B19K-gene synergise with DNA-damaging drugs through attenuation of DNA-damage repair responses and checkpoint activation in pancreatic cancer cells . HUMAN GENE THERAPY . vol. 25 , A17 - A17 .

Hughes J, Wang P, Alusi G, Bhakta V, Chu Y, Shi H, McNeish I, McCart A et al. ( 2014 ) . Backbone selection for development of tumour-targeted oncolyti Vaccinia virus for cancer treatment . HUMAN GENE THERAPY . vol. 25 , A22 - A23 .

Ahmed J, Yuan M, Alusi G, Lemoine NR, Wang Y ( 2014 ) . Chapter 16 The Lister Strain of Vaccinia Virus as an Anticancer Therapeutic Agent . Gene Therapy of Cancer , Elsevier

Dayem Ullah AZ, Cutts RJ, Ghetia M, Gadaleta E, Hahn SA, Crnogorac-Jurcevic T, Lemoine NR, Chelala C ( 2014 ) . The pancreatic expression database: recent extensions and updates . Nucleic Acids Res vol. 42 , ( Database issue ) D944 - D949 .

Dayem Ullah AZ, Lemoine NR, Chelala C ( 2013 ) . A practical guide for the functional annotation of genetic variations using SNPnexus . Brief Bioinform vol. 14 , ( 4 ) 437 - 447 .

Coleman S, Chioni A-M, Ghallab M, Lemoine N, Grose RP, Kocher H ( 2013 ) . 538 Nuclear Translocation of FGFR1 and FGF2 in Pancreatic Stellate Cells Is Necessary for Pancreatic Cancer Cell Invasion . Gastroenterology vol. 144 , ( 5 ) s - 98 .

Barry S, Chelala C, Lines K, Sunamura M, Wang A, Marelli-Berg FM, Brennan C, Lemoine NR et al. ( 2013 ) . S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells . Clin Exp Metastasis vol. 30 , ( 3 ) 251 - 264 .

Hiley CT, Chard LS, Gangeswaran R, Tysome JR, Briat A, Lemoine NR, Wang Y ( 2013 ) . Vascular endothelial growth factor A promotes vaccinia virus entry into host cells via activation of the Akt pathway . J Virol vol. 87 , ( 5 ) 2781 - 2790 .

Szlosarek PW, Steele J, Sheaff M, Szyszko T, Ellis S, Nolan L, Taylor P, Gilligan D et al. ( 2013 ) . A RANDOMISED PHASE II TRIAL OF PEGYLATED ARGININE DEIMINASE IN PATIENTS WITH MALIGNANT PLEURAL MESOTHELIOMA . JOURNAL OF THORACIC ONCOLOGY vol. 8 , S308 - S308 .

Chard LS, Maniati E, Wang P, Hughes J, Wang J, Denes B, Fodor I, Hagemann T et al. ( 2013 ) . A Vaccinia Virus Armed with Interleukin-10 That Dampens Host Immunity to the Vctor but Not to Tumor Is a Promising Therapeutic Agent for Pancreatic Cancer . MOLECULAR THERAPY . vol. 21 , S196 - S196 .

Hughes J, Wang P, Alusi G, Bhakta V, Chu Y, Shi H, McNeish I, McCart A et al. ( 2013 ) . Lister Strain Vaccinia Virus Demonstrates Favourable Anti-Tumor Efficacy and Tumor-Selectivity Compared to Western Reserve Strain . MOLECULAR THERAPY . vol. 21 , S216 - S216 .

Crnogorac-Jurcevic T, Chelala C, Barry S, Harada T, Bhakta V, Lattimore S, Jurcevic S, Bronner M et al. ( 2013 ) . Molecular analysis of precursor lesions in familial pancreatic cancer . PLoS One vol. 8 , ( 1 )

Coleman S, Chioni A-M, Ghallab M, Lemoine N, Grose RP, Kocher H ( 2013 ) . Nuclear Translocation of FGFR1 and FGF2 in Pancreatic Stellate Cells Is Necessary for Pancreatic Cancer Cell Invasion . GASTROENTEROLOGY . vol. 144 , S98 - S98 .

Coleman SJ, Chioni A-M, Ghallab M, Anderson RK, Lemoine NR, Grose RP, Kocher HM ( 2013 ) . Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells is necessary for pancreatic cancer cell invasion . Pancreatology vol. 13 , ( 1 ) e10 - e11 .

Ahmed J, Yuan M, Alusi G, Lemoine NR, Wang Y ( 2013 ) . The Lister Strain of Vaccinia Virus as an Anticancer Therapeutic Agent . Gene Therapy of Cancer: Translational Approaches from Preclinical Studies to Clinical Implementation: Third Edition ,

Tysome JR, Lemoine NR, Wang Y ( 2013 ) . Update on oncolytic viral therapy - targeting angiogenesis . Onco Targets Ther vol. 6 , 1031 - 1040 .

Tysome JR, Li X, Wang S, Wang P, Gao D, Du P, Chen D, Gangeswaran R et al. ( 2012 ) . A novel therapeutic regimen to eradicate established solid tumors with an effective induction of tumor-specific immunity . Clin Cancer Res vol. 18 , ( 24 ) 6679 - 6689 .

Adam V, Ekblad M, Sweeney K, Müller H, Busch KH, Johnsen CT, Kang NR, Lemoine NR et al. ( 2012 ) . Synergistic and Selective Cancer Cell Killing Mediated by the Oncolytic Adenoviral Mutant AdΔΔ and Dietary Phytochemicals in Prostate Cancer Models . Hum Gene Ther vol. 23 , ( 9 ) 1003 - 1015 .

Gadaleta E, Cutts RJ, Sangaralingam A, Lemoine NR, Chelala C ( 2012 ) . An Integrated Systems Approach to the Study of Pancreatic Cancer . Systems Biology in Cancer Research and Drug Discovery , Springer Nature

Delage B, Luong P, Maharaj L, O'Riain C, Syed N, Crook T, Hatzimichael E, Papoudou-Bai A et al. ( 2012 ) . Promoter methylation of argininosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autophagy and caspase-dependent apoptosis . Cell Death Dis vol. 3 , ( 7 )

Cutts RJ, Dayem Ullah AZ, Sangaralingam A, Gadaleta E, Lemoine NR, Chelala C ( 2012 ) . O-miner: an integrative platform for automated analysis and mining of -omics data . Nucleic Acids Res vol. 40 , ( Web Server issue ) W560 - W568 .

Dayem Ullah AZ, Lemoine NR, Chelala C ( 2012 ) . SNPnexus: a web server for functional annotation of novel and publicly known genetic variants (2012 update) . Nucleic Acids Res vol. 40 , ( Web Server issue ) W65 - W70 .

Sweeney KG, Cheong SC, Lemoine NR, Hallden G ( 2012 ) . Abstract 2712: A non-replicating adenovirus expressing Hey1 is cytotoxic to prostate cancer cells . Cancer Research vol. 72 , ( 8_Supplement ) 2712 - 2712 .

Maya-Pineda HR, Miranda-Rota E, Lemoine NR, Halldén G ( 2012 ) . Abstract 2713: Adenovirus E1A binding to p300 is essential for synergistic cell killing in combination with chemotherapeutic drugs in prostate cancer cells . Cancer Research vol. 72 , ( 8_Supplement ) 2713 - 2713 .

Wong HH, Jiang G, Gangeswaran R, Wang P, Wang J, Yuan M, Wang H, Bhakta V et al. ( 2012 ) . Modification of the early gene enhancer-promoter improves the oncolytic potency of adenovirus 11 . Mol Ther vol. 20 , ( 2 ) 306 - 316 .

Wang P, Jiang G, Chard L, Wang J, Gao D, Cao H, Lemoine NR, Wang Y ( 2012 ) . A Rationally Designed Oncolytic Adenovirus, Ad-TD-IL-12, Cures Pancreatic Cancer in the Immunocompetent Syrian Hamster . MOLECULAR THERAPY . vol. 20 , S131 - S131 .

Miranda E, Maya Pineda H, Öberg D, Cherubini G, Garate Z, Lemoine NR, Halldén G ( 2012 ) . Adenovirus-mediated sensitization to the cytotoxic drugs docetaxel and mitoxantrone is dependent on regulatory domains in the E1ACR1 gene-region . PLoS One vol. 7 , ( 10 )

Ferguson MS, Lemoine NR, Wang Y ( 2012 ) . Systemic delivery of oncolytic viruses: hopes and hurdles . Adv Virol vol. 2012 ,

Cherubini G, Kallin C, Mozetic A, Hammaren-Busch K, Müller H, Lemoine NR, Halldén G ( 2011 ) . The oncolytic adenovirus AdΔΔ enhances selective cancer cell killing in combination with DNA-damaging drugs in pancreatic cancer models . Gene Ther vol. 18 , ( 12 ) 1157 - 1165 .

Dumartin L, Whiteman HJ, Weeks ME, Hariharan D, Dmitrovic B, Iacobuzio-Donahue CA, Brentnall TA, Bronner MP et al. ( 2011 ) . AGR2 is a novel surface antigen that promotes the dissemination of pancreatic cancer cells through regulation of cathepsins B and D . Cancer Res vol. 71 , ( 22 ) 7091 - 7102 .

Gadaleta E, Cutts RJ, Kelly GP, Crnogorac-Jurcevic T, Kocher HM, Lemoine NR, Chelala C ( 2011 ) . A global insight into a cancer transcriptional space using pancreatic data: importance, findings and flaws . Nucleic Acids Res vol. 39 , ( 18 ) 7900 - 7907 .

Bhattacharyya M, Francis J, Eddouadi A, Lemoine NR, Halldén G ( 2011 ) . An oncolytic adenovirus defective in pRb-binding (dl922-947) can efficiently eliminate pancreatic cancer cells and tumors in vivo in combination with 5-FU or gemcitabine . Cancer Gene Ther vol. 18 , ( 10 ) 734 - 743 .

Tysome JR, Wang P, Alusi G, Briat A, Gangeswaran R, Wang J, Bhakta V, Fodor I et al. ( 2011 ) . Lister vaccine strain of vaccinia virus armed with the endostatin-angiostatin fusion gene: an oncolytic virus superior to dl1520 (ONYX-015) for human head and neck cancer . Hum Gene Ther vol. 22 , ( 9 ) 1101 - 1108 .

Gadaleta E, Lemoine NR, Chelala C ( 2011 ) . Online resources of cancer data: barriers, benefits and lessons . Brief Bioinform vol. 12 , ( 1 ) 52 - 63 .

Cutts RJ, Gadaleta E, Hahn SA, Crnogorac-Jurcevic T, Lemoine NR, Chelala C ( 2011 ) . The Pancreatic Expression database: 2011 update . Nucleic Acids Res vol. 39 , ( Database issue ) D1023 - D1028 .

Cutts RJ, Gadaleta E, Lemoine NR, Chelala C ( 2011 ) . Using BioMart as a framework to manage and query pancreatic cancer data . Database (Oxford) vol. 2011 ,

Dumartin L, Whiteman HJ, Weeks ME, Timms JF, Brentnall TA, Bronner MP, Brennan C, Lemoine NR et al. ( 2010 ) . AGR2 Regulates the Invasion of Pancreatic Cancer Cells Through Cathepsins B and D . PANCREAS vol. 39 , ( 8 ) 1318 - 1319 .

Jiang G, Cao F, Ren G, Gao D, Bhakta V, Zhang Y, Cao H, Dong Z et al. ( 2010 ) . PRSS3 promotes tumour growth and metastasis of human pancreatic cancer . Gut vol. 59 , ( 11 ) 1535 - 1544 .

Sweeney K, Cheong SC, Lemoine N, Hallden G ( 2010 ) . A non-replicating adenovirus expressing Hey1 is cytotoxic to prostate cancer cells . HUMAN GENE THERAPY . vol. 21 , 1398 - 1398 .

Ekblad M, Oberg D, Lemoine N, Hallden G ( 2010 ) . Development of an oncolytic adenovirus expressing the prodrug-converting enzyme CD/UPRT (Ad Delta Delta CU) . HUMAN GENE THERAPY . vol. 21 , 1473 - 1473 .

Radhakrishnan S, Miranda E, Ekblad M, Holford A, Pizarro MT, Lemoine NR, Halldén G ( 2010 ) . Efficacy of oncolytic mutants targeting pRb and p53 pathways is synergistically enhanced when combined with cytotoxic drugs in prostate cancer cells and tumor xenografts . Hum Gene Ther vol. 21 , ( 10 ) 1311 - 1325 .

Cherubini G, Kalllin C, Mozetic A, Hammaren-Busch K, Muller H, Lemoine N, Hallden G ( 2010 ) . Investigating a new potent and selective oncolytic adenovirus (Ad Delta Delta) in combination with chemotherapy . HUMAN GENE THERAPY . vol. 21 , 1473 - 1474 .

Mao XY, Yu YW, Boyd LK, Ren GP, Lin DM, Chaplin T, Kudahetti SC, Stankiewicz E et al. ( 2010 ) . Distinct Genomic Alterations in Prostate Cancers in Chinese and Western Populations Suggest Alternative Pathways of Prostate Carcinogenesis . CANCER RES vol. 70 , ( 13 ) 5207 - 5212 .

Wong HH, Lemoine NR ( 2010 ) . Novel therapies for pancreatic cancer: setbacks and progress . Future Oncol vol. 6 , ( 7 ) 1061 - 1064 .

Delage B, Fennell DA, Nicholson L, McNeish I, Lemoine NR, Crook T, Szlosarek PW ( 2010 ) . Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer . Int J Cancer vol. 126 , ( 12 ) 2762 - 2772 .

Hiley CT, Yuan M, Lemoine NR, Wang Y ( 2010 ) . Lister strain vaccinia virus, a potential therapeutic vector targeting hypoxic tumours . Gene Ther vol. 17 , ( 2 ) 281 - 287 .

Oberg D, Yanover E, Adam V, Sweeney K, Costas C, Lemoine NR, Halldén G ( 2010 ) . Improved potency and selectivity of an oncolytic E1ACR2 and E1B19K deleted adenoviral mutant in prostate and pancreatic cancers . Clin Cancer Res vol. 16 , ( 2 ) 541 - 553 .

Wong HH, Lemoine NR, Wang Y ( 2010 ) . Oncolytic viruses for cancer therapy: overcoming the obstacles . Viruses vol. 2 , ( 1 ) 78 - 106 .

Sziosarek PW, Delage B, O'Riain C, Hatzimichael E, Crook T, Calaminici M, Gribben JG, Lemoine N et al. ( 2010 ) . Effect of inactivation of argininosuccinate synthetase on sensitivity of lymphomas to caspase-dependent apoptosis following treatment with arginine deiminase . JOURNAL OF CLINICAL ONCOLOGY vol. 28 , ( 15 )

Tysome JR, Lemoine NR, Wang YH ( 2009 ) . Combination of anti-angiogenic therapy and virotherapy: Arming oncolytic viruses with anti-angiogenic genes . CURR OPIN MOL THER vol. 11 , ( 6 ) 664 - 669 .

Pardo OE, Latigo J, Jeffery RE, Nye E, Poulsom R, Spencer-Dene B, Lemoine NR, Stamp GW et al. ( 2009 ) . The fibroblast growth factor receptor inhibitor PD173074 blocks small cell lung cancer growth in vitro and in vivo . Cancer Res vol. 69 , ( 22 ) 8645 - 8651 .

Peerlinck I, Merron A, Baril P, Conchon S, Martin-Duque P, Hindorf C, Burnet J, Quintanilla M et al. ( 2009 ) . Targeted radionuclide therapy using a Wnt-targeted replicating adenovirus encoding the Na/I symporter . Clin Cancer Res vol. 15 , ( 21 ) 6595 - 6601 .

Tysome JR, Briat A, Alusi G, Cao F, Gao D, Yu J, Wang P, Yang S et al. ( 2009 ) . Lister strain of vaccinia virus armed with endostatin-angiostatin fusion gene as a novel therapeutic agent for human pancreatic cancer . Gene Ther vol. 16 , ( 10 ) 1223 - 1233 .

Seckl MJ, Pardo OE, Aboagye EO, Latigo J, Stamp G, Lemoine N, Spencer-Dean B ( 2009 ) . The FGF receptor (FGFR) inhibitor PD0173074 blocks SCLC growth in vitro and in vivo . J THORAC ONCOL vol. 4 , ( 9 ) S385 - S385 .

Wong HH, Lemoine NR ( 2009 ) . Pancreatic cancer: molecular pathogenesis and new therapeutic targets (vol 6, pg 412, 2009) . NAT REV GASTRO HEPAT vol. 6 , ( 8 ) 440 - 440 .

Jasani B, Wyllie FS, Wright PA, Lemoine NR, Williams ED, Wynford-Thomas D ( 2009 ) . Immunocytochemically Detectable TGF-β Associated with Malignancy in Thyroid Epithelial Neoplasia . Growth Factors vol. 2 , ( 2 ) 149 - 155 .

Wong HH, Lemoine NR ( 2009 ) . Pancreatic cancer: molecular pathogenesis and new therapeutic targets . Nat Rev Gastroenterol Hepatol vol. 6 , ( 7 ) 412 - 422 .

Wang Y, Gangeswaran R, Zhao X, Wang P, Tysome J, Bhakta V, Yuan M, Chikkanna-Gowda CP et al. ( 2009 ) . CEACAM6 attenuates adenovirus infection by antagonizing viral trafficking in cancer cells . J Clin Invest vol. 119 , ( 6 ) 1604 - 1615 .

Adam V, Oberg D, Lemoine N, Hallden G ( 2009 ) . Prostate Cancer Targeting by Replication-Selective Adenoviral Mutants: Combination Treatments with Phytochemical Drugs . MOLECULAR THERAPY . vol. 17 , S320 - S320 .

Tysome JR, Briat A, Hiley C, Gangeswaran R, Chikkanna-Gowda CP, Bhakta V, Alusi G, Trivedi K et al. ( 2009 ) . Systemic Delivery of Lister Strain Vaccinia Virus to Tumors Is Facilitated by the Depletion of Macrophages in Immuno-Competent Mice . MOLECULAR THERAPY . vol. 17 , S247 - S247 .

( 2009 ) . BSGT 2009 Oral Presentations . Human Gene Therapy . vol. 20 , 389 - 395 .

Leitner S, Sweeney K, Oberg D, Davies D, Miranda E, Lemoine NR, Halldén G ( 2009 ) . Oncolytic adenoviral mutants with E1B19K gene deletions enhance gemcitabine-induced apoptosis in pancreatic carcinoma cells and anti-tumor efficacy in vivo . Clin Cancer Res vol. 15 , ( 5 ) 1730 - 1740 .

Chelala C, Khan A, Lemoine NR ( 2009 ) . SNPnexus: a web database for functional annotation of newly discovered and public domain single nucleotide polymorphisms . Bioinformatics vol. 25 , ( 5 ) 655 - 661 .

Marinov M, Ziogas A, Pardo OE, Tan LT, Dhillon T, Mauri FA, Lane HA, Lemoine NR et al. ( 2009 ) . AKT/mTOR pathway activation and BCL-2 family proteins modulate the sensitivity of human small cell lung cancer cells to RAD001 . Clin Cancer Res vol. 15 , ( 4 ) 1277 - 1287 .

Lemoine NR ( 2009 ) . Molecular Advances in Pancreatic Cancer . Digestion vol. 58 , ( 6 ) 550 - 556 .

Chelala C, Lemoine NR, Hahn SA, Crnogorac-Jurcevic T ( 2009 ) . A web-based platform for mining pancreatic expression datasets . Pancreatology vol. 9 , ( 4 ) 340 - 343 .

Wong HH, Gangeswaran R, Francis J, Lemoine NR, Wang Y ( 2009 ) . Adenovirus 11 is an Alternative Oncolytic Virus Targeting Adenovirus 5-Insensitive Cancer and Shows Distinct E1A Gene Transcriptional Activity . MOLECULAR THERAPY . vol. 17 , S235 - S236 .

Harada T, Chelala C, Crnogorac-Jurcevic T, Lemoine NR ( 2009 ) . Genome-wide analysis of pancreatic cancer using microarray-based techniques . Pancreatology vol. 9 , ( 1-2 ) 13 - 24 .

Tysome JR, Briat A, Alusi G, Cao F, Yu J, Wang P, Yang S, Dong Z et al. ( 2009 ) . Lister strain of vaccinia virus armed with endostatin–angiostatin fusion gene as a novel therapeutic agent for human pancreatic cancerVaccine strain of vaccinia virus for cancer therapy . Gene Therapy vol. 16 , ( 10 ) 1223 - 1233 .

Antonello D, Gobbo S, Corbo V, Sipos B, Lemoine NR, Scarpa A ( 2009 ) . Update on the molecular pathogenesis of pancreatic tumors other than common ductal adenocarcinoma . Pancreatology vol. 9 , ( 1-2 ) 25 - 33 .

Scupoli MT, Sartoris S, Tosi G, Ennas MG, Nicolis M, Cestari T, Zamboni G, Martignoni G et al. ( 2008 ) . Expression of MHC class I and class II antigens in pancreatic adenocarcinomas . HLA vol. 48 , ( 4 ) 301 - 311 .

Lemoine NR ( 2008 ) . Genetic Intervention for Therapy and Prevention of Pancreatic Cancer . Digestive Surgery vol. 11 , ( 3-6 ) 170 - 177 .

Yuan M, Tomlinson V, Lara R, Holliday D, Chelala C, Harada T, Gangeswaran R, Manson-Bishop C et al. ( 2008 ) . Yes-associated protein (YAP) functions as a tumor suppressor in breast . Cell Death Differ vol. 15 , ( 11 ) 1752 - 1759 .

Adam V, Lemoine N, Hallden G ( 2008 ) . Prostate cancer targeting by replication-selective adenoviral mutants: combination treatments with phytochemical drugs . HUMAN GENE THERAPY . vol. 19 , 1165 - 1165 .

Peerlinck I, Amini-Nik S, Phillips RK, Iggo R, Lemoine NR, Tejpar S, Vassaux G ( 2008 ) . Therapeutic potential of replication-selective oncolytic adenoviruses on cells from familial and sporadic desmoid tumors . Clin Cancer Res vol. 14 , ( 19 ) 6187 - 6192 .

Weeks ME, Hariharan D, Petronijevic L, Radon TR, Whiteman HJ, Kocher HM, Timms JF, Lemoine NR et al. ( 2008 ) . Analysis of the urine proteome in patients with pancreatic ductal adenocarcinoma . PROTEOM CLIN APPL vol. 2 , ( 7-8 ) 1047 - 1057 .

Montiel-Equihua CA, Martín-Duque P, de la Vieja A, Quintanilla M, Burnet J, Vassaux G, Lemoine NR ( 2008 ) . Targeting sodium/iodide symporter gene expression for estrogen-regulated imaging and therapy in breast cancer . Cancer Gene Ther vol. 15 , ( 7 ) 465 - 473 .

Tysome J, Alusi G, Fodor I, Lemoine N, Wang Y ( 2008 ) . Abstracts of the Spring 2008 Meeting of the Otorhinolaryngological Research SocietyThe following are the abstracts of the Spring 2008 Meeting of the Otorhinolaryngological Research Society held on 31st March 2008 at the University Hospital Coventry, Coventry, UK . Clinical Otolaryngology vol. 33 , ( 3 ) 300 - 300 .

Moss C, Lemoine N ( 2008 ) . RNA Interference and Dominant Negative Approaches . Viral Therapy of Cancer , Wiley

Baird SK, Aerts JL, Eddaoudi A, Lockley M, Lemoine NR, McNeish IA ( 2008 ) . Oncolytic adenoviral mutants induce a novel mode of programmed cell death in ovarian cancer . Oncogene vol. 27 , ( 22 ) 3081 - 3090 .

Baird SK, Ingemarsdotter CK, Eddaoudi A, Lockley M, Lemoine NR, McNeish IA ( 2008 ) . Oncolytic adenoviral mutants define a novel mode of programmed cell death in ovarian cancer . HUMAN GENE THERAPY . vol. 19 , 399 - 399 .

Adam VS, Lemoine N, Hallden G ( 2008 ) . Prostate cancer targeting by replication-selective adenoviral mutants: Combination treatments with phytochemical drugs . HUMAN GENE THERAPY . vol. 19 , 419 - 419 .

Harada T, Chelala C, Bhakta V, Chaplin T, Caulee K, Baril P, Young BD, Lemoine NR ( 2008 ) . Genome-wide DNA copy number analysis in pancreatic cancer using high-density single nucleotide polymorphism arrays . Oncogene vol. 27 , ( 13 ) 1951 - 1960 .

Wong HH, Lemoine NR ( 2008 ) . Biological approaches to therapy of pancreatic cancer . Pancreatology vol. 8 , ( 4-5 ) 431 - 461 .

Cheong SC, Wang Y, Meng J-H, Hill R, Sweeney K, Kirn D, Lemoine NR, Halldén G ( 2008 ) . E1A-expressing adenoviral E3B mutants act synergistically with chemotherapeutics in immunocompetent tumor models . Cancer Gene Ther vol. 15 , ( 1 ) 40 - 50 .

Danovi SA, Wong HH, Lemoine NR ( 2008 ) . Targeted therapies for pancreatic cancer . Br Med Bull vol. 87 , 97 - 130 .

Lemoine NR ( 2008 ) . The clinician-scientist: a rare breed under threat in a hostile environment . Dis Model Mech vol. 1 , ( 1 ) 12 - 14 .

Marinov M, Ziogas A, Pardo OE, Tan LT, Lane HA, Lemoine NR, Zangemeister-Wittke U, Seckl MJ et al. ( 2007 ) . Akt/mTOR pathway activation and Bcl-2 family proteins modulate the sensitivity of human small cell lung cancer cells to RAD001 (Everolimus) . MOL CANCER THER vol. 6 , ( 12 ) 3409S - 3409S .

Aiuti A, Bachoud-Levi AC, Blesch A, Brenner MK, Cattaneo F, Chiocca EA, Gao G, High KA et al. ( 2007 ) . Progress and prospects: gene therapy clinical trials (part 2) (vol 14, pg 1555, 2007) . GENE THER vol. 14 , ( 24 ) 1754 - 1754 .

Chelala C, Hahn SA, Whiteman HJ, Barry S, Hariharan D, Radon TP, Lemoine NR, Crnogorac-Jurcevic T ( 2007 ) . Pancreatic Expression database: a generic model for the organization, integration and mining of complex cancer datasets . BMC GENOMICS vol. 8 , Article 439 ,

Aiuti A, Bachoud-Lévi AC, Blesch A, Brenner MK, Cattaneo F, Chiocca EA, Gao G, High KA et al. ( 2007 ) . Progress and prospects: gene therapy clinical trials (part 2) . Gene Ther vol. 14 , ( 22 ) 1555 - 1563 .

Löhr M, Lemoine NR ( 2007 ) . Novel Treatments and Gene Therapy in Pancreatic Cancer . Clinical Pancreatology , Wiley

Moss C, Lemoine N ( 2007 ) . RNA Interference . The Cancer Handbook , Wiley

Bond JA, Gescher AJ, Verschoyle RD, Lemoine NR, Errington R, Wiltshire M, Smith PJ, Wynford-Thomas D ( 2007 ) . Cytotoxic action of phorbol esters on human pancreatic cancer cells . INT J CANCER vol. 121 , ( 7 ) 1445 - 1454 .

Cheong SC, Lemoine N, Hallden G ( 2007 ) . Inhibition of androgen receptor signaling pathways in prostate cancer cells by adenoviral vectors expressing Hey1 . HUMAN GENE THERAPY . vol. 18 , 1004 - 1004 .

Whiteman HJ, Weeks ME, Dowen SE, Barry S, Timms JF, Lemoine NR, Crnogorac-Jurcevic T ( 2007 ) . The role of S100P in the invasion of pancreatic cancer cells is mediated through cytoskeletal changes and regulation of cathepsin D . Cancer Res vol. 67 , ( 18 ) 8633 - 8642 .

Mahon PC, Baril P, Bhakta V, Chelala C, Caulee K, Harada T, Lemoine NR ( 2007 ) . S100A4 contributes to the suppression of BNIP3 expression, chemoresistance, and inhibition of apoptosis in pancreatic cancer . Cancer Res vol. 67 , ( 14 ) 6786 - 6795 .

Lopes RB, Gangeswaran R, McNeish IA, Wang YH, Lemoine NR ( 2007 ) . Expression of the IAP protein family is dysregulated in pancreatic cancer cells and is important for resistance to chemotherapy . INT J CANCER vol. 120 , ( 11 ) 2344 - 2352 .

Radhakrishnan S, Hallden G, Chinegwundoh F, Lemoine N ( 2007 ) . Synergistic enhancement of prostate cancer cell death by combination therapy of adenovirus and chemotherapy . BJU INTERNATIONAL . vol. 99 , 28 - 28 .

Sheikh AA, Vimalachandran D, Thompson CC, Jenkins RE, Nedjadi T, Shekouh A, Campbell F, Dodson A et al. ( 2007 ) . The expression of S100A8 in pancreatic cancer-associated monocytes is associated with the Smad4 status of pancreatic cancer cells . PROTEOMICS . vol. 7 , 1929 - 1940 .

Pandha H, Rigg A, John J, Lemoine N ( 2007 ) . Loss of expression of antigen-presenting molecules in human pancreatic cancer and pancreatic cancer cell lines . CLIN EXP IMMUNOL vol. 148 , ( 1 ) 127 - 135 .

Radhakrishnan S, Hallden GK, Chinegwundoh F, Lemoine N ( 2007 ) . Synergistic enhancement of cell death by combination therapy with adenovirus and chemotherapy . JOURNAL OF UROLOGY . vol. 177 , 182 - 183 .

Baril P, Gangeswaran R, Mahon PC, Caulee K, Kocher HM, Harada T, Zhu M, Kalthoff H et al. ( 2007 ) . Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta4 integrin and the PI3k pathway . Oncogene vol. 26 , ( 14 ) 2082 - 2094 .

Neesse A, Gangeswaran R, Luettges J, Feakins R, Weeks ME, Lemoine NR, Crnogorac-Jurcevic T ( 2007 ) . Sperm-associated antigen 1 is expressed early in pancreatic tumorigenesis and promotes motility of cancer cells . Oncogene vol. 26 , ( 11 ) 1533 - 1545 .

Harada T, Baril P, Gangeswaran R, Kelly G, Chelala C, Bhakta V, Caulee K, Mahon PC et al. ( 2007 ) . Identification of genetic alterations in pancreatic cancer by the combined use of tissue microdissection and array-based comparative genomic hybridisation . Br J Cancer vol. 96 , ( 2 ) 373 - 382 .

Thompson CC, Ashcroft FJ, Patel S, Saraga G, Vimalachandran D, Prime W, Campbell F, Dodson A et al. ( 2007 ) . Pancreatic cancer cells overexpress gelsolin family-capping proteins, which contribute to their cell motility . GUT vol. 56 , ( 1 ) 95 - 106 .

SIKORA K, HARRIS J, HURST H, LEMOINE N ( 2006 ) . Therapeutic Strategies Using c‐erb B‐2 Promoter‐Controlled Drug Activationa . Annals of the New York Academy of Sciences vol. 716 , ( 1 ) 115 - 125 .

Bapat U, Wang Y, Alusi G, Chisholm E, Francis J, Hallden G, Lemoine N ( 2006 ) . Oncolytic virotherapy for nasopharyngeal cancer . Clinical Otolaryngology vol. 31 , ( 6 ) 582 - 583 .

Neesse A, Gangeswaran R, Luettges J, Feakins R, Weeks ME, Lemoine NR, Crnogorac-Jurcevic T ( 2006 ) . Sperm associated antigen 1 (spag1) is expressed early in pancreatic tumorigenesis and promotes motility of cancer cells . PANCREAS vol. 33 , ( 4 ) 485 - 486 .

Vimalachandran D, Sheikh A, Tweedle E, Khattak I, Thompson CC, Jenkins RE, Nedjadi T, Shekouh A et al. ( 2006 ) . The expression of S100A8 in tumour-associated monocytes is directly associated with the Smad4 status of pancreatic cancer cells . PANCREAS vol. 33 , ( 4 ) 506 - 506 .

Leyton J, Lockley M, Aerts JL, Baird SK, Aboagye EO, Lemoine NR, McNeish IA ( 2006 ) . Quantifying the activity of adenoviral E1A CR2 deletion mutants using renilla luciferase bioluminescence and 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography imaging . Cancer Res vol. 66 , ( 18 ) 9178 - 9185 .

Barton CM, McKie AB, Hogg A, Bia B, Elia G, Phillips SMA, Ding S, Lemoine NR ( 2006 ) . Abnormalities of the RB1 and DCC tumor suppressor genes: Uncommon in human pancreatic adenocarcinoma . Molecular Carcinogenesis vol. 13 , ( 2 ) 61 - 69 .

Wyllie FS, Lemoine NR, Barton CM, Dawson T, Bond J, Wynford‐Thomas D ( 2006 ) . Direct growth stimulation of normal human epithelial cells by mutant p53 . Molecular Carcinogenesis vol. 7 , ( 2 ) 83 - 88 .

Bond J, Dawson T, Lemoine N, Wynford‐Thomas D ( 2006 ) . Effect of serum growth factors and phorbol ester on growth and survival of human thyroid epithelial cells expressing mutant ras . Molecular Carcinogenesis vol. 5 , ( 2 ) 129 - 135 .

O'Sullivan C, Barton CM, Staddon SL, Brown CL, Lemoine NR ( 2006 ) . Activating point mutations of the gsp oncogene in human thyroid adenomas . Molecular Carcinogenesis vol. 4 , ( 5 ) 345 - 349 .

McKie AB, Lemoine NR, Filipe MI ( 2006 ) . Abnormalities affecting the APC and MCC tumour suppressor gene loci on chromosome 5q occur frequently in gastric cancer but not in pancreatic cancer . International Journal of Cancer vol. 55 , ( 4 ) 598 - 603 .

Lemoine NR, Hughes CM, Gullick WJ, Brown CL, Wynford‐Thomas D ( 2006 ) . Abnormalities of the EGF receptor system in human thyroid neoplasia . International Journal of Cancer vol. 49 , ( 4 ) 558 - 561 .

Leung HY, Gullick WJ, Lemoine NR ( 2006 ) . Expression and functional activity of fibroblast growth factors and their receptors in human pancreatic cancer . International Journal of Cancer vol. 59 , ( 5 ) 667 - 675 .

Sanidas EE, Filipe MI, Linehan J, Lemoine NR, Gullick WJ, Rajkumar T, Levison DA ( 2006 ) . Expression of the c‐erbB‐3 gene product in gastric cancer . International Journal of Cancer vol. 54 , ( 6 ) 935 - 940 .

Lemoine NR, Hall PA ( 2006 ) . Epithelial tumors metastatic to the uterine cervix. A study of 33 cases and review of the literature . Cancer vol. 57 , ( 10 ) 2002 - 2005 .

Capurso G, Lattimore S, Crnogorac-Jurcevic T, Panzuto F, Milione M, Bhakta V, Campanini N, Swift SM et al. ( 2006 ) . Gene expression profiles of progressive pancreatic endocrine tumours and their liver metastases reveal potential novel markers and therapeutic targets . ENDOCR-RELAT CANCER vol. 13 , ( 2 ) 541 - 558 .

Khan SA, Taylor-Robinson SD, Carmichael PL, Habib N, Lemoine NR, Thomas HC ( 2006 ) . Analysis of p53 mutations for a mutational signature in human intrahepatic cholangiocarcinoma . Int J Oncol vol. 28 , ( 5 ) 1269 - 1277 .

Martin-Duque P, Quintanilla M, McNeish I, Lopes R, Romero J, Romero D, Lemoine NR, Cajal SRY et al. ( 2006 ) . Caspase-1 as a radio- and chemo-sensitiser in vitro and in vivo . INT J MOL MED vol. 17 , ( 5 ) 841 - 847 .

Bhattacharrya M, Lemoine NR ( 2006 ) . Gene therapy developments for pancreatic cancer . BEST PRACT RES CL GA vol. 20 , ( 2 ) 285 - 298 .

RIGG AS, LEMOINE NR ( 1999 ) . Genetic Prodrug Activation Therapy for Pancreatic Cancer . Annals of the New York Academy of Sciences . vol. 880 , 319 - 325 .

Chernajovsky Y, Layward L, Lemoine N ( 2006 ) . Controversy - Fighting cancer with oncolytic viruses . BRIT MED J vol. 332 , ( 7534 ) 170 - 172 .

Chernajovsky Y, Layward L, Lemoine N ( 2006 ) . Fighting cancer with oncolytic viruses . BMJ vol. 332 , ( 7534 ) 170 - 172 .

Lockley M, Fernandez M, Wang Y, Li NF, Conroy S, Lemoine N, McNeish I ( 2006 ) . Activity of the adenoviral E1A deletion mutant dl922-947 in ovarian cancer: comparison with E1A wild-type viruses, bioluminescence monitoring, and intraperitoneal delivery in icodextrin . Cancer Res vol. 66 , ( 2 ) 989 - 998 .

Vassaux G, Nitcheu J, Jezzard S, Lemoine NR ( 2006 ) . Bacterial gene therapy strategies . J Pathol vol. 208 , ( 2 ) 290 - 298 .

Baird SK, Lockley M, Leyton J, Aboagye EO, Lemoine NR, McNeish IA ( 2006 ) . E1A CR2 deletion mutant adenoviral vectors in ovarian cancer: combination with apoptosis inducers and monitoring with [18F] FLT-PET imaging . CANCER RESEARCH . vol. 66 ,

Bhattacharyya M, Hallden G, Francis J, Lemoine NR ( 2006 ) . Synergistic interactions between adenovirus and chemotherapy in pancreatic cancer cell lines: Effects of chemotherapy on expression of coxsackie-adenovirus receptor (CAR) and infectability by adenovirus . CANCER RESEARCH . vol. 66 ,

Martin-Duque P, Quintanilla M, McNeish I, Lopes R, Romero J, Romero D, Lemoine NR, Cajal SRY et al. ( 2005 ) . Radio- and chemo-sensitization by caspase-1 in vitro and in vivo . CLINICAL CANCER RESEARCH . vol. 11 , 8996S - 8996S .

Kashiwagi H, Spigelman AD, Talbot IC, Debinski HS, McKie AB, Lemoine NR, Phillips RKS ( 2005 ) . p53 and K-ras status in duodenal adenomas in familial adenomatous polyposis . British Journal of Surgery vol. 84 , ( 6 ) 826 - 829 .

Arencibia JM, Del Rio M, Bonnin A, Lopes R, Lemoine NR, López-Barahona M ( 2005 ) . Doxazosin induces apoptosis in LNCaP prostate cancer cell line through DNA binding and DNA-dependent protein kinase down-regulation . Int J Oncol vol. 27 , ( 6 ) 1617 - 1623 .

Crnogorac-Jurcevic T, Gangeswaran R, Bhakta V, Capurso G, Lattimore S, Akada M, Sunamura M, Prime W et al. ( 2005 ) . Proteomic analysis of chronic pancreatitis and pancreatic adenocarcinoma . Gastroenterology vol. 129 , ( 5 ) 1454 - 1463 .

Thompson C, Ashcroft F, Saraga G, Vimalachandran D, Patel S, Prime W, Campbell F, Dodson A et al. ( 2005 ) . THE ACTIN CAPPING PROTEINS, CAPG AND GELSOLIN, ARE OVEREXPRESSED IN PANCREATIC CANCER: IMPLICATIONS FOR CANCER CELL MOTILITY AND PATIENT SURVIVAL . Pancreas vol. 31 , ( 4 ) 473 - 474 .

Smith PG, Oakley F, Fernandez M, Mann DA, Lemoine NR, Whitehouse A ( 2005 ) . Herpesvirus saimiri-based vector biodistribution using noninvasive optical imaging . Gene Ther vol. 12 , ( 19 ) 1465 - 1476 .

Vimalachandran CD, Watson R, Thompson CC, Greenhalf W, Yan L, Prime W, Campbell F, Dodson A et al. ( 2005 ) . High nuclear A100A6 (calcyclin) is significantly associated with poor survival in pancreatic cancer patients . BRITISH JOURNAL OF SURGERY . vol. 92 , 1313 - 1314 .

Liu T-C, Wang Y, Hallden G, Brooks G, Francis J, Lemoine NR, Kirn D ( 2005 ) . Functional interactions of antiapoptotic proteins and tumor necrosis factor in the context of a replication-competent adenovirus . Gene Ther vol. 12 , ( 17 ) 1333 - 1346 .

Lemoine NR ( 2005 ) . Silencing RNA: a novel treatment for pancreatic cancer? . GUT vol. 54 , ( 9 ) 1215 - 1216 .

HALL PA, LEMOINE NR, RYAN JF ( 2005 ) . Carcinoma of the gall bladder metastatic to the cervix. Case report . BJOG An International Journal of Obstetrics & Gynaecology vol. 93 , ( 11 ) 1187 - 1190 .

Lopes R, Castro I, Pontes P, Candeias J, Lemoine NR, Sambade C ( 2005 ) . Expression profile of survivin in acute leukaemias: the importance of differential splicing . Leukemia vol. 19 , ( 7 ) 1284 - 1286 .

Petralia GA, Lemoine NR, Kakkar AK ( 2005 ) . Mechanisms of disease: the impact of antithrombotic therapy in cancer patients . Nat Clin Pract Oncol vol. 2 , ( 7 ) 356 - 363 .

Hall PA, Coates P, Lemoine NR, Horton MA ( 2005 ) . Characterization of integrin chains in normal and neoplastic human pancreas . The Journal of Pathology vol. 165 , ( 1 ) 33 - 41 .

Hall PA, Hughes CM, Staddon SL, Richman PI, Gullick WJ, Lemoine NR ( 2005 ) . The c‐erbB‐2 proto‐oncogene in human pancreatic cancer . The Journal of Pathology vol. 161 , ( 3 ) 195 - 200 .

Barton CM, Hall PA, Hughes CM, Gullick WJ, Lemoine NR ( 2005 ) . Transforming growth factor alpha and epidermal growth factor in human pancreatic cancer . The Journal of Pathology vol. 163 , ( 2 ) 111 - 116 .

Lemoine NR, Hughes CM, Cowell JK ( 2005 ) . Aberrant expression of the tumour suppressor gene p53 is very frequent in Wilms' tumours . The Journal of Pathology vol. 168 , ( 2 ) 237 - 242 .

Rajkumar T, Gooden CS, Lemoine NR, Gullick WJ, Goden CS ( 2005 ) . Expression of the C‐erbB‐3 protein in gastrointestinal tract tumours determined by monoclonal antibody RTJ1 . The Journal of Pathology vol. 170 , ( 3 ) 271 - 278 .

Lemoine NR ( 2005 ) . Growth factors and oncogenes . The Journal of Pathology vol. 168 , ( 4 ) 419 - 422 .

Gullick WJ, Hughes CM, Mellon K, Neal DE, Lemoine NR ( 2005 ) . Immunohistochemical detection of the epidermal growth factor receptor in paraffin‐embedded human tissues . The Journal of Pathology vol. 164 , ( 4 ) 285 - 289 .

Hall PA, Lemoine NR ( 2005 ) . Koch's postulates revisited . The Journal of Pathology vol. 164 , ( 4 ) 283 - 284 .

Gullick WJ, Lemoine NR, Langbeheim H ( 2005 ) . Letters to the editor . The Journal of Pathology vol. 162 , ( 3 ) 275 - 276 .

Pignatelli M, Ansari TW, Gunter P, Liu D, Hirano S, Takeichi M, Klöppel G, Lemoine NR ( 2005 ) . Loss of membranous E‐cadherin expression in pancreatic cancer: Correlation with lymph node metastasis, high grade, and advanced stage . The Journal of Pathology vol. 174 , ( 4 ) 243 - 248 .

Barnard NJ, Hall PA, Lemoine NR, Kadar N ( 2005 ) . Proliferative index in breast carcinoma determined in situ by Ki67 immunostaining and its relationship to clinical and pathological variables . The Journal of Pathology vol. 152 , ( 4 ) 287 - 295 .

Hall PA, Lemoine NR ( 2005 ) . Rapid acinar to ductal transdifferentiation in cultured human exocrine pancreas . The Journal of Pathology vol. 166 , ( 2 ) 97 - 103 .

Lemoine NR, Lobresco M, Leung H, Barton C, Hughes CM, Prigent SA, Gullick WJ, Klöppel G ( 2005 ) . The erbB‐3 Gene in human pancreatic cancer . The Journal of Pathology vol. 168 , ( 3 ) 269 - 273 .

Buluwela L, Pike J, Mazhar D, Kamalati T, Hart SM, Al-Jehani R, Yahaya H, Patel N et al. ( 2005 ) . Inhibiting estrogen responses in breast cancer cells using a fusion protein encoding estrogen receptor-alpha and the transcriptional repressor PLZF (vol 12, pg 452, 2005) . GENE THER vol. 12 , ( 10 ) 862 - 862 .

Vimalachandran D, Greenhalf W, Thompson C, Luttges J, Prime W, Campbell F, Dodson A, Watson R et al. ( 2005 ) . High nuclear S100A6 (Calcyclin) is significantly associated with poor survival in pancreatic cancer patients . CANCER RES vol. 65 , ( 8 ) 3218 - 3225 .

Akada M, Crnogorac-Jurcevic T, Lattimore S, Mahon P, Lopes R, Sunamura M, Matsuno S, Lemoine NR ( 2005 ) . Intrinsic chemoresistance to gemcitabine is associated with decreased expression of BNIP3 in pancreatic cancer . CLIN CANCER RES vol. 11 , ( 8 ) 3094 - 3101 .

Lemoine NR ( 2005 ) . Antithrombotic therapy in cancer . J Clin Oncol vol. 23 , ( 10 ) 2119 - 2120 .

Capurso G, Lattimore S, Crnogorac-Jurcevic T, Panzuto F, Milione M, Bhakta V, Bordi C, Lemoine NR et al. ( 2005 ) . Gene expression profiles of non-functioning primary and metastatic pancreatic endocrine tumours (pets) reveal potential new markers and targets for therapy . GASTROENTEROLOGY . vol. 128 , A483 - A483 .

Buluwela L, Pike J, Mazhar D, Kamalati T, Hart SM, Al-Jehani R, Yahaya H, Patel N et al. ( 2005 ) . Inhibiting estrogen responses in breast cancer cells using a fusion protein encoding estrogen receptor-alpha and the transcriptional repressor PLZF (vol 12, pg 452, 2005) . GENE THER vol. 12 , ( 6 ) 552 - 552 .

Buluwela L, Pike J, Mazhar D, Kamalati T, Hart SM, Al-Jehani R, Yahaya H, Patel N et al. ( 2005 ) . Inhibiting estrogen responses in breast cancer cells using a fusion protein encoding estrogen receptor-alpha and the transcriptional repressor PLZF . Gene Ther vol. 12 , ( 5 ) 452 - 460 .

Wang Y, Xue S-A, Hallden G, Francis J, Yuan M, Griffin BE, Lemoine NR ( 2005 ) . Virus-associated RNA I-deleted adenovirus, a potential oncolytic agent targeting EBV-associated tumors . Cancer Res vol. 65 , ( 4 ) 1523 - 1531 .

Missiaglia E, Donadelli M, Palmieri M, Crnogorac-Jurcevic T, Scarpa A, Lemoine NR ( 2005 ) . Growth delay of human pancreatic cancer cells by methylase inhibitor 5-aza-2'-deoxycytidine treatment is associated with activation of the interferon signalling pathway . Oncogene vol. 24 , ( 1 ) 199 - 211 .

Wang Y, Thorne S, Hannock J, Francis J, Au T, Reid T, Lemoine N, Kirn D et al. ( 2005 ) . A novel assay to assess primary human cancer infectibility by replication-selective oncolytic adenoviruses . Clin Cancer Res vol. 11 , ( 1 ) 351 - 360 .

Stoll V, Calleja V, Vassaux G, Downward J, Lemoine NR ( 2005 ) . Dominant negative inhibitors of signalling through the phosphoinositol 3-kinase pathway for gene therapy of pancreatic cancer . Gut vol. 54 , ( 1 ) 109 - 116 .

Dowen SE, Crnogorac-Jurcevic T, Gangeswaran R, Hansen M, Eloranta JJ, Bhakta V, Brentnall TA, Luttges J et al. ( 2005 ) . Expression of S100P and its novel binding partner S100PBPR in early pancreatic cancer . AM J PATHOL vol. 166 , ( 1 ) 81 - 92 .

Capurso G, Crnogorac-Jurcevic T, Milione M, Panzuto F, Campanini N, Dowen SE, Di Florio A, Sette C et al. ( 2005 ) . Peanut-like 1 (septin 5) gene expression in normal and neoplastic human endocrine pancreas . Neuroendocrinology vol. 81 , ( 5 ) 311 - 321 .

McNeish IA, Lopes R, Bell SJ, McKay TR, Fernandez M, Lockley M, Wheatley SP, Lemoine NR ( 2005 ) . Survivin interacts with Smac/DIABLO in ovarian carcinoma cells but is redundant in Smac-mediated apoptosis . Exp Cell Res vol. 302 , ( 1 ) 69 - 82 .

Savage P, Cowburn P, Clemens D, Hurley T, Laguda B, Martin-Duque P, Vassaux G, Lemoine NR ( 2004 ) . Suicide gene therapy conversion of ethanol to acetaldehyde mediated by human beta 2 alcohol dehydrogenase . CANCER GENE THER vol. 11 , ( 12 ) 774 - 781 .

Petrovska L, Aspinall RJ, Barber L, Clare S, Simmons CP, Stratford R, Khan SA, Lemoine NR et al. ( 2004 ) . Salmonella enterica serovar Typhimurium interaction with dendritic cells: impact of the sifA gene . CELL MICROBIOL vol. 6 , ( 11 ) 1071 - 1084 .

Missiaglia E, Blaveri E, Terris B, Wang Y-H, Costello E, Neoptolemos JP, Crnogorac-Jurcevic T, Lemoine NR ( 2004 ) . Analysis of gene expression in cancer cell lines identifies candidate markers for pancreatic tumorigenesis and metastasis . Int J Cancer vol. 112 , ( 1 ) 100 - 112 .

El‐Hariry I, Jordinson M, Lemoine N, Pignatelli M ( 2004 ) . Characterization of the E‐cadherin–catenin complexes in pancreatic carcinoma cell lines . The Journal of Pathology vol. 188 , ( 2 ) 155 - 162 .

Pike J, Holmes D, Kamalati T, Davies D, Tolhurst R, Mazhar D, Fishpool S, al-Jehani R et al. ( 2004 ) . Silencing of androgen-regulated genes using a fusion of AR with the PLZF transcriptional repressor . Oncogene vol. 23 , ( 45 ) 7561 - 7570 .

Pardo OE, Lesay A, Arcaro A, Lopes R, Ng BL, Warne PH, McNeish IA, Tetley TD et al. ( 2004 ) . Fibroblast growth factor 2-mediated translational control of IAPs blocks mitochondrial release of Smac/DIABLO and apoptosis in small cell lung cancer cells (vol 23, pg 7600, 2003) . MOL CELL BIOL vol. 24 , ( 15 ) 6887 - 6887 .

Critchley RJ, Jezzard S, Radford KJ, Goussard S, Lemoine NR, Grillot-Courvalin C, Vassaux G ( 2004 ) . Potential therapeutic applications of recombinant, invasive E. coli . Gene Ther vol. 11 , ( 15 ) 1224 - 1233 .

Groot-Wassink T, Aboagye EO, Wang Y, Lemoine NR, Keith WN, Vassaux G ( 2004 ) . Noninvasive imaging of the transcriptional activities of human telomerase promoter fragments in mice . Cancer Res vol. 64 , ( 14 ) 4906 - 4911 .

Leslie J, McFaul C, Earl J, Azadeh B, Prime W, Bartsch D, Harada T, Lemoine N et al. ( 2004 ) . Identification of a familial pancreatic cancer gene by focusing haplotype analysis using LOH in sporadic cancer . BRITISH JOURNAL OF CANCER . vol. 91 , S31 - S31 .

Wang Y, Faux SP, Hallden G, Kirn DH, Houghton CE, Lemoine NR, Patrick G ( 2004 ) . Interleukin-1beta and tumour necrosis factor-alpha promote the transformation of human immortalised mesothelial cells by erionite . Int J Oncol vol. 25 , ( 1 ) 173 - 178 .

Vimalachandran D, Watson R, Shekouh A, Thompson C, Campbell F, Prime W, Crngorac-Jurcevic T, Lemoine N et al. ( 2004 ) . The calcium binding protein s100A6 (calcyclin) as a prognostic indicator in pancreatic cancer . BRITISH JOURNAL OF CANCER . vol. 91 , S32 - S32 .

Liu T-C, Hallden G, Wang Y, Brooks G, Francis J, Lemoine N, Kirn D ( 2004 ) . An E1B-19 kDa gene deletion mutant adenovirus demonstrates tumor necrosis factor-enhanced cancer selectivity and enhanced oncolytic potency . Mol Ther vol. 9 , ( 6 ) 786 - 803 .

Burn J, Lemoine N, O'Toole L ( 2004 ) . Assessing cancer risk . Expert Rev Anticancer Ther vol. 4 Suppl 1 , S13 - S17 .

Kakkar AK, Levine MN, Kadziola Z, Lemoine NR, Low V, Patel HK, Rustin G, Thomas M et al. ( 2004 ) . Low molecular weight heparin, therapy with dalteparin, and survival in advanced cancer: the fragmin advanced malignancy outcome study (FAMOUS) . J Clin Oncol vol. 22 , ( 10 ) 1944 - 1948 .

Madhusudan S, Tamir A, Bates N, Flanagan E, Gore ME, Barton DPJ, Harper P, Seckl M et al. ( 2004 ) . A multicenter Phase I gene therapy clinical trial involving intraperitoneal administration of E1A-lipid complex in patients with recurrent epithelial ovarian cancer overexpressing HER-2/neu oncogene . Clin Cancer Res vol. 10 , ( 9 ) 2986 - 2996 .

Yaohe, Pen H, Jennelle, Gunnel, Shao-an, Grriffin BE, Lemoine NR ( 2004 ) . Anti-CD22 immunolipoplexes enhance transduction of adenovirus in B lymphoma cells independent on adenovirus' receptor but do not enhance the cytotoxicity of oncolytic adenovirus . MOLECULAR THERAPY . vol. 9 , S171 - S172 .

Liu TC, Wang YH, Hallden G, Francis J, Brooks G, Lemoine N, Kirn D ( 2004 ) . Oncolytic adenovirus E1B-19kD deletion and E3B retention results in both enhanced potency and tumor necrosis factor-mediated selectivity . MOLECULAR THERAPY . vol. 9 , S109 - S109 .

Hill RJ, Hallden GK, Wang YH, Francis J, Simpson C, Kirn DH, Lemoine NR ( 2004 ) . The gene expression and function of adenoviral E3-genes in murine tumour cell lines . MOLECULAR THERAPY . vol. 9 , S374 - S375 .

Wang YH, Xue SA, Hallden G, Francis J, Griffin BE, Lemoine NR ( 2004 ) . VAI deleted adenovirus as an oncolytic agent targeting human EBV-associated tumours . MOLECULAR THERAPY . vol. 9 , S230 - S230 .

Lemoine NR, McNeish IA ( 2004 ) . Gene transfer: Bax to the future for cancer therapy . Gut vol. 53 , ( 4 ) 478 - 479 .

Marani M, Hancock D, Lopes R, Tenev T, Downward J, Lemoine NR ( 2004 ) . Role of Bim in the survival pathway induced by Raf in epithelial cells . Oncogene vol. 23 , ( 14 ) 2431 - 2441 .

McNeish IA, Bell SJ, Lemoine NR ( 2004 ) . Gene therapy progress and prospects: cancer gene therapy using tumour suppressor genes . Gene Ther vol. 11 , ( 6 ) 497 - 503 .

Groot-Wassink T, Aboagye EO, Wang Y, Lemoine NR, Reader AJ, Vassaux G ( 2004 ) . Quantitative imaging of Na/I symporter transgene expression using positron emission tomography in the living animal . Mol Ther vol. 9 , ( 3 ) 436 - 442 .

Capurso G, Delle Fave G, Lemoine N ( 2004 ) . Re: Etiology of pancreatic cancer, with a hypothesis concerning the role of N-nitroso compounds and excess gastric acidity . J Natl Cancer Inst vol. 96 , ( 1 )

Brown NL, Lemoine NR ( 2004 ) . Clinical trials with GDEPT: cytosine deaminase and 5-fluorocytosine . Methods Mol Med vol. 90 , 451 - 457 .

Nasir FA, Patel HK, Scully MF, Fareed J, Lemoine NR, Kakkar AK ( 2003 ) . The low molecular weight heparins dalteparin sodium inhibits angiogenesis and induces apoptosis in an experimental tumour model . BLOOD . vol. 102 , 808A - 808A .

Wang Y, Hallden G, Hill R, Anand A, Liu T-C, Francis J, Brooks G, Lemoine N et al. ( 2003 ) . E3 gene manipulations affect oncolytic adenovirus activity in immunocompetent tumor models . Nat Biotechnol vol. 21 , ( 11 ) 1328 - 1335 .

Pardo OE, Lesay A, Arcaro A, Lopes R, Ng BL, Warne PH, McNeish IA, Tetley TD et al. ( 2003 ) . Fibroblast growth factor 2-mediated translational control of IAPs blocks mitochondrial release of Smac/DIABLO and apoptosis in small cell lung cancer cells . Mol Cell Biol vol. 23 , ( 21 ) 7600 - 7610 .

Shekouh AR, Thompson CC, Prime W, Campbell F, Hamlett J, Herrington CS, Lemoine NR, Crnogorac-Jurcevic T et al. ( 2003 ) . Application of laser capture microdissection combined with two-dimensional electrophoresis for the discovery of differentially regulated proteins in pancreatic ductal adenocarcinoma . Proteomics vol. 3 , ( 10 ) 1988 - 2001 .

Wang Y, Groot-Wassink T, Lemoine NR, Vassaux G ( 2003 ) . Cellular characterization of the tropism of recombinant adenovirus for the adrenal glands . Eur J Clin Invest vol. 33 , ( 9 ) 794 - 798 .

Crnogorac-Jurcevic T, Missiaglia E, Blaveri E, Gangeswaran R, Jones M, Terris B, Costello E, Neoptolemos JP et al. ( 2003 ) . Molecular alterations in pancreatic carcinoma: expression profiling shows that dysregulated expression of S100 genes is highly prevalent . J Pathol vol. 201 , ( 1 ) 63 - 74 .

Halldén G, Hill R, Wang Y, Anand A, Liu T-C, Lemoine NR, Francis J, Hawkins L et al. ( 2003 ) . Novel immunocompetent murine tumor models for the assessment of replication-competent oncolytic adenovirus efficacy . Mol Ther vol. 8 , ( 3 ) 412 - 424 .

Lemoine NR, Kirby RB ( 2003 ) . UK cash for gene therapy: government pledges support . Gene Ther vol. 10 , ( 17 ) 1405 - 1406 .

Radford KJ, Jackson AM, Wang J-H, Vassaux G, Lemoine NR ( 2003 ) . Recombinant E. coli efficiently delivers antigen and maturation signals to human dendritic cells: presentation of MART1 to CD8+ T cells . Int J Cancer vol. 105 , ( 6 ) 811 - 819 .

Zhu G, Reynolds L, Crnogorac-Jurcevic T, Gillett CE, Dublin EA, Marshall JF, Barnes D, D'Arrigo C et al. ( 2003 ) . Combination of microdissection and microarray analysis to identify gene expression changes between differentially located tumour cells in breast cancer . Oncogene vol. 22 , ( 24 ) 3742 - 3748 .

McNeish IA, Bell S, McKay T, Tenev T, Marani M, Lemoine NR ( 2003 ) . Expression of Smac/DIABLO in ovarian carcinoma cells induces apoptosis via a caspase-9-mediated pathway . Exp Cell Res vol. 286 , ( 2 ) 186 - 198 .

McKay TR, Bell S, Tenev T, Stoll V, Lopes R, Lemoine NR, McNeish IA ( 2003 ) . Procaspase 3 expression in ovarian carcinoma cells increases survivin transcription which can be countered with a dominant-negative mutant, survivin T34A; a combination gene therapy strategy . Oncogene vol. 22 , ( 23 ) 3539 - 3547 .

VAN TRAPPEN P ( 2003 ) . Combination of microdissection and microarray analysis to identify gene expression changes between differentially located tumour cells in breast cancer . Oncogene vol. 22 , 3742 - 3748 .

Groot-Wassink T, Barthel H, Lemoine NR, Vassaux G ( 2003 ) . Sodium iodide symporter: a new strategy to target cancer? . Lancet vol. 361 , ( 9372 ) 1905 - 1906 .

Liu TC, Wang YH, Hallden G, Anand A, Lemoine NR, Kirn DH ( 2003 ) . Adenoviral E1B-19kD deletion results in enhanced oncolytic effect and reduced toxicity in an immunocompetent murine tumor . MOLECULAR THERAPY . vol. 7 , S416 - S416 .

Wang YH, Francis J, Griffin BE, Lemoine NLR, Xue SA ( 2003 ) . Cytotoxicity of replication-competent adenovirus to lymphoproliferative disorders correlates with expression of heparan sulfate . MOLECULAR THERAPY . vol. 7 , S359 - S359 .

Hill RJ, Hallden GK, Lemoine NR, Kirn DH ( 2003 ) . In vitro screening of murine carcinoma cell lines for testing of replication-competent oncolytic adenoviruses . MOLECULAR THERAPY . vol. 7 , S362 - S362 .

Aspinali RJ, Clare S, Goulding D, Goldin RD, Lemoine NR, Dougan G ( 2003 ) . Microbiology and cellular pathology of infection with sifA-mutant Salmonella typhimurium . GASTROENTEROLOGY . vol. 124 , A484 - A484 .

Crnogorac-Jurcevic T, Lemoine NR ( 2003 ) . Molecular profiles of pancreatic adenocarcinoma . GUT . vol. 52 , A36 - A36 .

Khan SA, Taylor-Robinson SD, Carmichael PL, Habib N, Lemoine N, Thomas HC ( 2003 ) . Novel p53 mutations but lack of a mutational fingerprint in human intrahepatic cholangiocarcinoma . GUT . vol. 52 , A32 - A32 .

Liu TC, Hallden G, Anand A, Wang YH, Lemoine N, Kirn D ( 2003 ) . Adenovirus E1B-19kD gene deletion enhances oncolytic virus efficacy and selectivity . CANCER GENE THERAPY . vol. 10 , S20 - S20 .

Lemoine NR ( 2002 ) . Risks and benefits of gene therapy for immunodeficiency: a reality check . GENE THER vol. 9 , ( 23 ) 1561 - 1562 .

Kakkar AK, Kadziola Z, Williamson RCN, Levine MN, Low V, Lemoine NR, Fragmin Adv Malignancy Outcome ( 2002 ) . Low molecular weight heparin (LMWH) therapy and survival in advanced cancer . BLOOD . vol. 100 , 148A - 148A .

Radford KJ, Higgins DE, Pasquini S, Cheadle EJ, Carta L, Jackson AM, Lemoine NR, Vassaux G ( 2002 ) . A recombinant E. coli vaccine to promote MHC class I-dependent antigen presentation: application to cancer immunotherapy . GENE THER vol. 9 , ( 21 ) 1455 - 1463 .

Campbell NJH, Lemoine NR, Glorioso JC ( 2002 ) . Information overload? Take the 'Progress and Prospects' cure . Gene Ther vol. 9 , ( 20 )

Groot-Wassink T, Aboagye EO, Glaser M, Lemoine NR, Vassaux G ( 2002 ) . Adenovirus biodistribution and noninvasive imaging of gene expression in vivo by positron emission tomography using human sodium/iodide symporter as reporter gene . Hum Gene Ther vol. 13 , ( 14 ) 1723 - 1735 .

Crnogorac-Jurcevic T, Efthimiou E, Nielsen T, Loader J, Terris B, Stamp G, Baron A, Scarpa A et al. ( 2002 ) . Expression profiling of microdissected pancreatic adenocarcinomas . Oncogene vol. 21 , ( 29 ) 4587 - 4594 .

Harrington K, Alvarez-Vallina L, Crittenden M, Gough M, Chong H, Diaz RM, Vassaux G, Lemoine N et al. ( 2002 ) . Cells as vehicles for cancer gene therapy: The missing link between targeted vectors and systemic delivery? . HUM GENE THER vol. 13 , ( 11 ) 1263 - 1280 .

McNeish IA, Bell S, McKay T, Tenev T, Stoll V, Lemoine NR ( 2002 ) . Expression of Smac/DIABLO in ovarian carcinoma cells induces apoptosis predominantly via a caspase-9-mediated pathway and enhances sensitivity to cisplatin and paclitaxel . BRIT J CANCER vol. 86 , S20 - S21 .

Marani M, Tenev T, Hancock D, Downward J, Lemoine NR ( 2002 ) . Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis . Mol Cell Biol vol. 22 , ( 11 ) 3577 - 3589 .

Tagawa T, Manvell M, Brown N, Keller M, Perouzel E, Murray KD, Harbottle RP, Tecle M et al. ( 2002 ) . Characterisation of LMD virus-like nanoparticles self-assembled from cationic liposomes, adenovirus core peptide mu (mu) and plasmid DNA . GENE THER vol. 9 , ( 9 ) 564 - 576 .

Terris B, Blaveri E, Crnogorac-Jurcevic T, Jones M, Missiaglia E, Ruszniewski P, Sauvanet A, Lemoine NR ( 2002 ) . Characterization of gene expression profiles in intraductal papillary-mucinous tumors of the pancreas . AM J PATHOL vol. 160 , ( 5 ) 1745 - 1754 .

Lemoine NR ( 2002 ) . The power to deliver: stem cells in gene therapy . Gene Ther vol. 9 , ( 10 ) 603 - 605 .

Savage P, Cowburn P, Clayton A, Man S, McMichael A, Lemoine N, Epenetos A, Ogg G ( 2002 ) . Induction of viral and tumour specific CTL responses using antibody targeted HLA class I peptide complexes . Br J Cancer vol. 86 , ( 8 ) 1336 - 1342 .

Savage P, Cowburn P, Clayton A, Man S, Lawson T, Ogg G, Lemoine N, McMichael A et al. ( 2002 ) . Anti-viral cytotoxic T cells inhibit the growth of cancer cells with antibody targeted HLA class I/peptide complexes in SCID mice . Int J Cancer vol. 98 , ( 4 ) 561 - 566 .

Pasquini S, Peralta S, Missiaglia E, Carta L, Lemoine NR ( 2002 ) . Prime-boost vaccines encoding an intracellular idiotype/GM-CSF fusion protein induce protective cell-mediated immunity in murine pre-B cell leukemia . Gene Ther vol. 9 , ( 8 ) 503 - 510 .

Aspinall RJ, Simmons CP, Petrovska L, Clare S, Khan S, Stratford R, Shea J, Holden DW et al. ( 2002 ) . Selective delivery of antigen to the class I MHC pathway by SifA-mutant Salmonella typhimurium - An assessment of vaccine vector potential . GASTROENTEROLOGY vol. 122 , ( 4 ) A535 - A535 .

Missiaglia E, Moore PS, Williamson J, Lemoine NR, Falconi M, Zamboni G, Scarpa A ( 2002 ) . Sex chromosome anomalies in pancreatic endocrine tumors . Int J Cancer vol. 98 , ( 4 ) 532 - 538 .

Lemoine N ( 2002 ) . 10th International Conference on Gene Therapy of Cancer. 13-15 December, 2001, Sidney Kimmel Cancer Center, San Diego, CA, USA . Expert Rev Anticancer Ther vol. 2 , ( 1 ) 9 - 11 .

Scarpa A, Orlandini S, Moore PS, Lemoine NR, Beghelli S, Baron A, Falconi M, Zamboni G ( 2002 ) . Dpc4 is expressed in virtually all primary and metastatic pancreatic endocrine carcinomas . VIRCHOWS ARCH vol. 440 , ( 2 ) 155 - 159 .

Martins LM, Iaccarino I, Tenev T, Gschmeissner S, Totty NF, Lemoine NR, Savopoulos J, Gray CW et al. ( 2002 ) . The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif . J Biol Chem vol. 277 , ( 1 ) 439 - 444 .

Terris B, Blaveri E, Crnogorac-Jurcevic T, Jones M, Missiaglia E, Lemoine N ( 2002 ) . Characterization of gene expression profiles in intraductal papillary-mucinous tumors of the pancreas . MODERN PATHOL vol. 15 , ( 1 ) 294A - 295A .

Sirivatanauksorn Y, Sirivatanauksorn V, Lemoine NR ( 2002 ) . DNA fingerprinting from cells captured by laser microdissection . Methods Enzymol vol. 356 , 289 - 294 .

Glorioso J, Lemoine N ( 2002 ) . Electronic submission, review and tracking system for gene therapy . GENE THER vol. 9 , ( 1 ) 1 - 1 .

Hawkins LK, Lemoine NR, Kirn D ( 2002 ) . Oncolytic biotherapy: a novel therapeutic platform . LANCET ONCOL vol. 3 , ( 1 ) 17 - 26 .

Crnogorac-Jurcevic T, Nielsen TO, Lemoine NR ( 2002 ) . RT-PCR from laser-capture microdissected samples . Methods Mol Biol vol. 193 , 197 - 204 .

Sirivatanauksorn V, Sirivatanauksorn Y, McKie AB, Lemoine NR ( 2002 ) . Use of DNA fingerprinting to detect genetic rearrangements in human cancer . Methods Mol Med vol. 68 , 107 - 114 .

El-Hariry I, Pignatelli M, Lemoine NR ( 2001 ) . FGF-1 and FGF-2 regulate the expression of E-cadherin and catenins in pancreatic adenocarcinoma . Int J Cancer vol. 94 , ( 5 ) 652 - 661 .

Moore PS, Sipos B, Orlandini S, Sorio C, Real FX, Lemoine NR, Gress T, Bassi C et al. ( 2001 ) . Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4 . Virchows Arch vol. 439 , ( 6 ) 798 - 802 .

Lemoine NR, Tenev T, McNeish L, Stoll V, Marani M, Vassaux G ( 2001 ) . Targeting suicide genes for cancer gene therapy . CANCER GENE THER vol. 8 , S17 - S17 .

Rigg AS, Lemoine NR ( 2001 ) . Adenoviral delivery of TIMP1 or TIMP2 can modify the invasive behavior of pancreatic cancer and can have a significant antitumor effect in vivo . CANCER GENE THER vol. 8 , ( 11 ) 869 - 878 .

Crnogorac-Jurcevic T, Efthimiou E, Capelli P, Blaveri E, Baron A, Terris B, Jones M, Tyson K et al. ( 2001 ) . Gene expression profiles of pancreatic cancer and stromal desmoplasia . Oncogene vol. 20 , ( 50 ) 7437 - 7446 .

Lemoine N ( 2001 ) . Genome medicine: gene therapy for the new millennium . IDrugs vol. 4 , ( 11 ) 1247 - 1249 .

Lemoine N ( 2001 ) . Tumor-selective transcriptional targeting for cancer gene therapy . CANCER GENE THER vol. 8 , ( 9 ) 691 - 691 .

Lemoine N ( 2001 ) . American Society of Gene Therapy - Fourth Annual Meeting. Emerging technologies. 30 May-3 June 2001, Seattle, WA, USA . IDrugs vol. 4 , ( 8 ) 901 - 903 .

Madhusudan S, Bates N, Flanagan E, Charnock FMC, Gore M, Barton DPJ, Harper, Karapetis C et al. ( 2001 ) . A multicentre phase I gene therapy clinical trial involving intraperitoneal administration of E1A-lipid complex in patients with epithelial overian cancer overexpressing HER-2/neu . BRIT J CANCER vol. 85 , 26 - 26 .

Sirivatanauksorn Y, Sirivatanauksorn V, Lemoine NR, Williamson RC, Davidson BR ( 2001 ) . Genomic homogeneity in fibrolamellar carcinomas . Gut vol. 49 , ( 1 ) 82 - 86 .

El-Hariry I, Pignatelli M, Lemoine NR ( 2001 ) . FGF-1 and FGF-2 modulate the E-cadherin/catenin system in pancreatic adenocarcinoma cell lines . BRIT J CANCER vol. 84 , ( 12 ) 1656 - 1663 .

McNeish IA, Tenev T, Bell S, Marani M, Vassaux G, Lemoine N ( 2001 ) . Herpes simplex virus thymidine kinase/ganciclovir-induced cell death is enhanced by co-expression of caspase-3 in ovarian carcinoma cells . CANCER GENE THER vol. 8 , ( 4 ) 308 - 319 .

Ariaens A, Taniguchi T, Crnogorac-Jurcevic T, Lemoine NR ( 2001 ) . Investigation of expression profiles associated with factor VIIa activation of TF signalling and TIMP1 upregulation in human pancreatic adenocarcinoma cells . J PATHOL vol. 193 , 27A - 27A .

Tenev T, Marani M, McNeish I, Lemoine NR ( 2001 ) . Pro-caspase-3 overexpression sensitises ovarian cancer cells to proteasome inhibitors . CELL DEATH DIFFER vol. 8 , ( 3 ) 256 - 264 .

Ghaneh P, Greenhalf W, Humphreys M, Wilson D, Zumstein L, Lemoine NR, Neoptolemos JP ( 2001 ) . Adenovirus-mediated transfer of p53 and p16(INK4a) results in pancreatic cancer regression in vitro and in vivo . Gene Ther vol. 8 , ( 3 ) 199 - 208 .

Efthimiou E, Crnogorac-Jurcevic T, Lemoine NR ( 2001 ) . Inherited predisposition to pancreatic cancer . GUT vol. 48 , ( 2 ) 143 - 147 .

Sirivatanauksorn V, Sirivatanauksorn Y, Gorman PA, Davidson JM, Sheer D, Moore PS, Scarpa A, Edwards PAW et al. ( 2001 ) . Non-random chromosomal rearrangements in pancreatic cancer cell lines identified by spectral karyotyping . INT J CANCER vol. 91 , ( 3 ) 350 - 358 .

Moore PS, Orlandini S, Zamboni G, Capelli P, Rigaud G, Falconi M, Bassi C, Lemoine NR et al. ( 2001 ) . Pancreatic tumours: molecular pathways implicated in ductal cancer are involved in ampullary but not in exocrine nonductal or endocrine tumorigenesis . BRIT J CANCER vol. 84 , ( 2 ) 253 - 262 .

Efthimiou E, Crnogorac-Jurcevic T, Lemoine NR ( 2001 ) . Pancreatic cancer genetics . Pancreatology vol. 1 , ( 6 ) 571 - 575 .

Martín-Duque P, Vassaux G, Lemoine N, Ramón y Cajal S ( 2001 ) . Prospects in cancer gene therapy . Oncologia vol. 24 , ( 6 ) 20 - 31 .

Lane R, Lemoine N, Hall C, Coats D ( 2000 ) . Oncology and the media . The Lancet Oncology vol. 1 , ( 4 ) 246 - 249 .

Zhao J, Tenev T, Martins LM, Downward J, Lemoine NR ( 2000 ) . The ubiquitin-proteasome pathway regulates survivin degradation in a cell cycle-dependent manner . J CELL SCI vol. 113 , ( 23 ) 4363 - 4371 .

Aspinall RJ, Lemoine NR ( 2000 ) . Suicide and the not-so-innocent bystander . Gut vol. 47 , ( 3 )

Thatcher NJ, Edwards RJ, Lemoine NR, Doehmer J, Davies DS ( 2000 ) . The potential of acetaminophen as a prodrug in gene-directed enzyme prodrug therapy . Cancer Gene Therapy vol. 7 , ( 4 ) 521 - 525 .

Scarpa A, Di Pace C, Talamini G, Falconi M, Lemoine NR, Iacono C, Achille A, Baron A et al. ( 2000 ) . Cancer of the ampulla of Vater: chromosome 17p allelic loss is associated with poor prognosis . Gut vol. 46 , ( 6 )

Ogg GS, Dunbar PR, Cerundolo V, McMichael AJ, Lemoine NR, Savage P ( 2000 ) . Sensitization of tumour cells to lysis by virus-specific CTL using antibody-targeted MHC class I/peptide complexes . British Journal of Cancer vol. 82 , ( 5 ) 1058 - 1062 .

Vile RG, Russell SJ, Lemoine NR ( 2000 ) . Cancer gene therapy: hard lessons and new courses . Gene Therapy vol. 7 , ( 1 ) 2 - 8 .

Rigaud G, Moore PS, Zamboni G, Orlandini S, Taruscio D, Paradisi S, Lemoine NR, Klöppel G et al. ( 2000 ) . Allelotype of pancreatic acinar cell carcinoma . International Journal of Cancer vol. 88 , ( 5 ) 772 - 777 .

Taniguchi T, Lemoine NR ( 2000 ) . Application of suppression subtractive hybridisation for identification of genes regulated by the TF-FVIIa pathway in pancreatic cancer . MOLECULAR PATHOGENESIS OF PANCREATIC CANCER . Editors: Gress, TM , vol. 41 , 57 - 59 .

Vassaux G, Lemoine NR ( 2000 ) . Gene therapy for carcinoma of the breast - Genetic toxins . BREAST CANCER RES vol. 2 , ( 1 ) 22 - 27 .

Kawesha A, Ghaneh P, Andrén‐Sandberg Å, Ögraed D, Skar R, Dawiskiba S, Evans JD, Campbell F et al. ( 2000 ) . K‐ras oncogene subtype mutations are associated with survival but not expression of p53, p16INK4A, p21WAF‐1, cyclin D1, erbB‐2 and erbB‐3 in resected pancreatic ductal adenocarcinoma . International Journal of Cancer vol. 89 , ( 6 ) 469 - 474 .

Lemoine NR, Sirivatanauksorn V, Crnogorac-Jurcevic T ( 2000 ) . Molecular profile of pancreatic cancer . MOLECULAR PATHOGENESIS OF PANCREATIC CANCER . Editors: Gress, TM , vol. 41 , 4 - 16 .

Sirivatanauksorn Y, Drury R, Crnogorac‐Jurčević T, Sirivatanauksorn V, Lemoine NR ( 1999 ) . Laser‐assisted microdissection: applications in molecular pathology . The Journal of Pathology vol. 189 , ( 2 ) 150 - 154 .

Sirivatanauksorn Y, Sirivatanauksorn V, Bhattacharya S, Davidson BR, Dhillon AP, Kakkar AK, Williamson RC, Lemoine NR ( 1999 ) . Genomic heterogeneity in synchronous hepatocellular carcinomas . Gut vol. 45 , ( 5 )

Sirivatanauksorn Y, Sirivatanauksorn V, Bhattacharya S, Davidson BR, Dhillon AP, Kakkar AK, Williamson RCN, Lemoine NR ( 1999 ) . Evolution of genetic abnormalities in hepatocellular carcinomas demonstrated by DNA fingerprinting . The Journal of Pathology vol. 189 , ( 3 ) 344 - 350 .

Habib NA, Hodgson HJ, Lemoine N, Pignatelli M ( 1999 ) . A Phase I/II Study of Hepatic Artery Infusion with wtp53-CMV-Ad in Metastatic Malignant Liver Tumours . Human Gene Therapy vol. 10 , ( 12 ) 2019 - 2034 .

Lemoine NR, Glorioso JC ( 1999 ) . Gene therapy for the millenium: in with the new . Gene Therapy vol. 6 , ( 7 ) 1199 - 1199 .

Pandha HS, Martin L-A, Rigg A, Hurst HC, Stamp GWH, Sikora K, Lemoine NR ( 1999 ) . Genetic Prodrug Activation Therapy for Breast Cancer: A Phase I Clinical Trial of erbB-2–Directed Suicide Gene Expression . Journal of Clinical Oncology vol. 17 , ( 7 ) 2180 - 2180 .

Kakkar AK, Chinswangwatanakul V, Lemoine NR, Tebbutt S, Williamson RCN ( 1999 ) . Role of tissue factor expression on tumour cell invasion and growth of experimental pancreatic adenocarcinoma . British Journal of Surgery vol. 86 , ( 7 ) 890 - 894 .

Vassaux G, Hurst HC, Lemoine NR ( 1999 ) . Insulation of a conditionally expressed transgene in an adenoviral vector . Gene Therapy vol. 6 , ( 6 ) 1192 - 1197 .

Schmitt JF, Keogh M-C, Dennehy U, Chen D, Lupu F, Weston K, Taylor D, Kakkar VV et al. ( 1999 ) . Tissue-selective expression of dominant-negative proteins for the regulation of vascular smooth muscle cell proliferation . Gene Therapy vol. 6 , ( 6 ) 1184 - 1191 .

Melcher A, Todryk S, Bateman A, Chong H, Lemoine NR, Vile RG ( 1999 ) . Adoptive transfer of immature dendritic cells with autologous or allogeneic tumor cells generates systemic antitumor immunity . Cancer Research vol. 59 , ( 12 ) 2802 - 2805 .

Hoorens A, Prenzel K, Lemoine NR, Klöppel G ( 1999 ) . Undifferentiated carcinoma of the pancreas: analysis of intermediate filament profile and Ki‐ras mutations provides evidence of a ductal origin . The Journal of Pathology vol. 185 , ( 1 ) 53 - 60 .

EL‐HARIRY I, PIGNATELLI M, LEMOINE N ( 1999 ) . FIBROBLAST GROWTH FACTOR 1 AND FIBROBLAST GROWTH FACTOR 2 IMMUNOREACTIVITY IN GASTROINTESTINAL TUMOURS . The Journal of Pathology vol. 181 , ( 1 ) 39 - 45 .

Bramhall SR, Neoptolemos JP, Stamp GWH, Lemoine NR ( 1999 ) . Imbalance of expression of matrix metalloproteinases (MMPs) and tissue inhibitors of the matrix metalloproteinases (TIMPs) in human pancreatic carcinoma . The Journal of Pathology vol. 182 , ( 3 ) 347 - 355 .

Keogh M-C, Chen D, Schmitt JF, Dennehy U, Kakkar VV, Lemoine NR ( 1999 ) . Design of a muscle cell-specific expression vector utilising human vascular smooth muscle α-actin regulatory elements . Gene Therapy vol. 6 , ( 4 ) 616 - 628 .

Pandha HS, Bateman AR, Lemoine NR ( 1999 ) . Dendritic cells in cancer immunotherapy . Drug News & Perspectives vol. 12 , ( 3 )

Aspinall RJ, Lemoine NR ( 1999 ) . Gene therapy for pancreatic and biliary malignancies . Annals of Oncology . vol. 10 , s188 - s192 .

McKie AB, Iwamura T, Leung HY, Hollingsworth MA, Lemoine NR ( 1998 ) . Alu‐polymerase chain reaction genomic fingerprinting technique identifies multiple genetic loci associated with pancreatic tumourigenesis . Genes Chromosomes and Cancer vol. 18 , ( 1 ) 30 - 41 .

Achille A, Scupoli MT, Magalini AR, Zamboni G, Romanelli MG, Orlandini S, Biasi MO, Lemoine NR et al. ( 1998 ) . APC gene mutations and allelic losses in sporadic ampullary tumours: Evidence of genetic difference from tumours associated with familial adenomatous polyposis . International Journal of Cancer vol. 68 , ( 3 ) 305 - 312 .

Taniguchi T, Lemoine NR, Kakkar AK ( 1998 ) . Urokinase receptor is a key player in tumour progression . Gut vol. 43 , ( 6 )

Todryk SM, Chong H, Vile RG, Pandha H, Lemoine NR ( 1998 ) . Can immunotherapy by gene transfer tip the balance against colorectal cancer? . Gut vol. 43 , ( 4 )

Taniguchi T, Kakkar AK, Tuddenham EG, Williamson RC, Lemoine NR ( 1998 ) . Enhanced expression of urokinase receptor induced through the tissue factor-factor VIIa pathway in human pancreatic cancer . Cancer Research vol. 58 , ( 19 ) 4461 - 4467 .

Rigg AS, Scarpa A, Pandha HS, Lemoine NR ( 1998 ) . Gene therapy for pancreatic cancer . Digestive and Liver Disease vol. 30 , ( 5 ) 462 - 466 .

Taniguchi T, Rigg A, Lemoine N ( 1998 ) . Targeting angiogenesis: genetic intervention which strikes at the weak link of tumorigenesis . Gene Therapy vol. 5 , ( 8 ) 1011 - 1013 .

Sirivatanauksorn V, Sirivatanauksorn Y, Lemoine NR ( 1998 ) . Molecular pattern of ductal pancreatic cancer . Langenbeck's Archives of Surgery vol. 383 , ( 2 ) 105 - 115 .

Zbar A, Lemoine N, Wadhwa M, Thomas H, Snary D, Kmiot W ( 1998 ) . Biological therapy: approaches in colorectal cancer . British Journal of Cancer vol. 77 , ( 5 ) 683 - 693 .

Lemoine N ( 1998 ) . Tumour-selective targeting of prodrug activation . British Journal of Cancer . vol. 78 ,

Martin L, Vile R, Lemoine N, Sikora K, Pandha H ( 1997 ) . Genetic prodrug activation therapy . The Lancet vol. 350 , ( 9094 ) 1793 - 1794 .

Ring C, Blouin P, Martin L-A, Hurst H, Lemoine N ( 1997 ) . Use of transcriptional regulatory elements of the MUC1 and ERBB2 genes to drive tumour-selective expression of a prodrug activating enzyme . Gene Therapy vol. 4 , ( 10 ) 1045 - 1052 .

Lemoine NR, Wynford-Thomas D ( 1997 ) . Transfection and Transformation of Human Thyroid Epithelial Cells . Methods in Molecular Biology vol. 75 , 441 - 447 .

Keogh M-C, Chen D, Lupu F, Shaper N, Schmitt J, Kakkar V, Lemoine N ( 1997 ) . High efficiency reporter gene transfection of vascular tissue in vitro and in vivo using a cationic lipid–DNA complex . Gene Therapy vol. 4 , ( 2 ) 162 - 171 .

Barton C, Lemoine N ( 1997 ) . Antisense oligonucleotides targeting p53 . Journal of Clinical Oncology vol. 15 , ( 1 )

Scupoli MT, Sartoris S, Tosi G, Ennas MG, Nicolis M, Cestari T, Zamboni G, Martignoni G et al. ( 1997 ) . Erratum: Expression of MHC class I and class II antigens in pancreatic adenocarcinomas (Tissue Antigens (1996) 48 (301-311)) . Tissue Antigens vol. 49 , ( 4 )

Ring CJ, Harris JD, Hurst HC, Lemoine NR ( 1996 ) . Suicide gene expression induced in tumour cells transduced with recombinant adenoviral, retroviral and plasmid vectors containing the ERBB2 promoter . Gene Therapy vol. 3 , ( 12 ) 1094 - 1103 .

Harris JD, Lemoine NR ( 1996 ) . Strategies for targeted gene therapy . Trends in Genetics vol. 12 , ( 10 ) 400 - 405 .

Martin L-A, Lemoine NR ( 1996 ) . Direct cell killing by suicide genes . Cancer and Metastasis Reviews vol. 15 , ( 3 ) 301 - 316 .

Bramhall S, Stamp G, Dunn J, Lemoine N, Neoptolemos J ( 1996 ) . Expression of collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of the metalloproteinases (TIMP1) in pancreatic and ampullary disease . British Journal of Cancer vol. 73 , ( 8 ) 972 - 978 .

F.P. LD, B. OH, J.A. RC, R. LN, George3 5AJT ( 1996 ) . ADENOVIRUS-MEDIATED GENE DELIVERY TO THE CORNEAL ENDOTHELIUM1 . Transplantation vol. 61 , ( 3 ) 363 - 370 .

Pandha HS, Lemoine NR ( 1996 ) . Gene therapy in gastroenterology . Gut vol. 38 , ( 2 )

Kakkar AK, Lemoine NR, Stone SR, Altieri D, Williamson RC ( 1995 ) . Identification of a thrombin receptor with factor Xa receptor and tissue factor in human pancreatic carcinoma cells . Molecular Pathology vol. 48 , ( 5 )

Lemoine NR, Pignatelli M ( 1995 ) . Type-1 growth factor receptors in pancreatic and gastrointestinal neoplasia . European Journal of Gastroenterology & Hepatology vol. 7 , ( 10 ) 939 - 944 .

Kakkar AK, Lemoine NR, Scully MF, Tebbutt S, Williamson RCN ( 1995 ) . Tissue factor expression correlates with histological grade in human pancreatic cancer . British Journal of Surgery vol. 82 , ( 8 ) 1101 - 1104 .

Lemoine NR ( 1995 ) . Oncogenes and cancer markers . Trends in Molecular Medicine vol. 1 , ( 4 ) 164 - 165 .

Oda T, Scarpa A, Fukao K, Lemoine NR, Hirohashi S ( 1995 ) . [Abnormal expression of E-cadherin in human pancreatic carcinoma cell lines] . Clinical journal of Japan vol. 53 , ( 7 ) 1595 - 1601 .

Carter G, Gilbert C, Lemoine N ( 1995 ) . Effects of antisense oligonucleotides targeting k-ras expression in pancreatic-cancer cell-lines . International Journal of Oncology vol. 6 , ( 5 ) 1105 - 1112 .

Barton C, Lemoine N ( 1995 ) . Antisense oligonucleotides directed against p53 have antiproliferative effects unrelated to effects on p53 expression . British Journal of Cancer vol. 71 , ( 3 ) 429 - 437 .

Di Renzo MF, Poulsom R, Olivero M, Comoglio PM, Lemoine NR ( 1995 ) . Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancer . Cancer Research vol. 55 , ( 5 ) 1129 - 1138 .

Phillips S, Barton C, Lee S, Morton D, Wallace D, Lemoine N, Neoptolemos J ( 1994 ) . Loss of the retinoblastoma susceptibility gene (RB1) is a frequent and early event in prostatic tumorigenesis . British Journal of Cancer vol. 70 , ( 6 ) 1252 - 1257 .

Ali M, Lemoine NR, Ring CJ ( 1994 ) . The use of DNA viruses as vectors for gene therapy . Gene Therapy vol. 1 , ( 6 ) 367 - 384 .

Hoorens A, Klöppel G, Gebhard F, Kraft K, Lemoine NR ( 1994 ) . Pancreatoblastoma in an adult: its separation from acinar cell carcinoma . Virchows Archiv vol. 424 , ( 5 ) 485 - 490 .

Harris JD, Gutierrez AA, Hurst HC, Sikora K, Lemoine NR ( 1994 ) . Gene therapy for cancer using tumour-specific prodrug activation . Gene Therapy vol. 1 , ( 3 ) 170 - 175 .

Lemoine NR ( 1994 ) . The molecular basis of human cancer. B. G. Neel and R. Kumar (eds). 233 × 152 mm. Pp. 491. Illustrated. 1993. Mount Kisco, New York: Futura Publishing. US $95 . British Journal of Surgery vol. 81 , ( 5 ) 781 - 781 .

Lemoine N, Beauchamp D ( 1994 ) . Growth factors and receptors . International Journal of Pancreatology . vol. 16 , 250 - 251 .

Lemoine NR, Hurst HC ( 1994 ) . Introduction . European Journal of Cancer vol. 30 , ( 13 )

Leung HY, Hughes CM, Kloppel G, Williamson RCN, Lemoine NR ( 1994 ) . Localisation of expression of fibroblast growth factors and their receptors in pancreatic adenocarcinoma by in situ hybridisation . International Journal of Oncology vol. 4 , ( 6 ) 1219 - 1223 .

Lemoine NR ( 1994 ) . Molecular biology of breast cancer . Annals of Oncology . vol. 5 , s31 - s37 .

Bi S, Barton CM, Lemoine NR, Cross NC, Goldman JM ( 1994 ) . Retroviral transduction of Philadelphia-positive chronic myeloid leukemia cells with a human mutant p53 cDNA and its effect on in vitro proliferation . Experimental Hematology vol. 22 , ( 1 ) 95 - 99 .

Gasparini G, Pozza F, Bevilacqua P, Gullick WJ, Lemoine NR, Maluta S, Palma PD, Caffo O et al. ( 1994 ) . c-erbB-3 and c-erbB-2 protein expression in node-negative breast carcinoma—an immunocytochemical study . European Journal of Cancer vol. 30 , ( 1 ) 16 - 22 .

Hoorens A, Lemoine NR, McLellan E, Morohoshi T, Kamisawa T, Heitz PU, Stamm B, Rüschoff J et al. ( 1993 ) . Pancreatic acinar cell carcinoma. An analysis of cell lineage markers, p53 expression, and Ki-ras mutation . American Journal Of Pathology vol. 143 , ( 3 ) 685 - 698 .

Carter G, Lemoine N ( 1993 ) . Antisense technology for cancer therapy: does it make sense? . British Journal of Cancer vol. 67 , ( 5 ) 869 - 876 .

Lemoine NR, Sikora K ( 1993 ) . Interventional genetics and cancer treatment . The BMJ vol. 306 , ( 6879 )

McLellan EA, Owen RA, Stepniewska KA, Sheffield JP, Lemoine NR ( 1993 ) . High frequency of K-ras mutations in sporadic colorectal adenomas . Gut vol. 34 , ( 3 )

Burns J, Barton C, Wynford-Thomas D, Lemoine N ( 1993 ) . In vitro transformation of epithelial cells by ras oncogenes . Epithelial Cell Biology vol. 2 , ( 1 ) 26 - 43 .

Hall PA, Lemoine NR ( 1993 ) . Models of pancreatic cancer . Cancer Surveys vol. 16 , 135 - 155 .

Gasparini G, Gullick WJ, Bevilacqua P, Pozza F, Lemoine NR, Meli S, Boracchi P, La Malfa G et al. ( 1993 ) . Pathobiological characteristics of the first primary and risk of metachronous contralateral invasive breast carcinoma: Clinical implications . International Journal of Oncology vol. 2 , ( 5 ) 781 - 790 .

Lemoine NR, Wright NA ( 1993 ) . The molecular pathology of cancer. Introduction . Cancer Surveys vol. 16 , 1 - 2 .

Lemoine N, Barnes D, Hollywood D, Hughes C, Smith P, Dublin E, Prigent S, Gullick W et al. ( 1992 ) . Expression of the ERBB3 gene product in breast cancer . British Journal of Cancer vol. 66 , ( 6 ) 1116 - 1121 .

Lemoine NR, Leung HY, Gullick WJ ( 1992 ) . Growth factors in the gastrointestinal tract . Gut vol. 33 , ( 10 )

Prigent SA, Lemoine NR, Hughes CM, Plowman GD, Selden C, Gullick WJ ( 1992 ) . Expression of the c-erbB-3 protein in normal human adult and fetal tissues . Oncogene vol. 7 , ( 7 ) 1273 - 1278 .

Kennedy RL, Jones TH, Davies R, Justice SK, Lemoine NR ( 1992 ) . Release of interleukin-6 by human thyroid epithelial cells immortalized by simian virus 40 DNA transfection . Journal of Endocrinology vol. 133 , ( 3 ) 477 - 482 .

Gutierrez AA, Lemoine NR, Sikora K ( 1992 ) . Gene therapy for cancer . The Lancet vol. 339 , ( 8795 ) 715 - 721 .

Barton CM, Staddon SL, Hughes CM, Hall PA, O'Sullivan C, Kloppel G, Theis B, Russell RCG et al. ( 1992 ) . Corrigendum: Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer (British Journal of Cancer (1991) 64 (1076)) . British Journal of Cancer vol. 65 , ( 3 )

Lemoine NR, Jain S, Hughes CM, Staddon SL, Maillet B, Hall PA, Klöppel G ( 1992 ) . Ki-ras oncogene activation in preinvasive pancreatic cancer . Gastroenterology vol. 102 , ( 1 ) 230 - 236 .

Prigent SA, Lemoine NR ( 1992 ) . The type 1 (EGFR-related) family of growth factor receptors and their ligands . Cytokine & Growth Factor Reviews vol. 4 , ( 1 ) 1 - 24 .

Barton C, Staddon S, Hughes C, Hall P, O'Sullivan C, Klöppel G, Theis B, Russell R et al. ( 1991 ) . Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer . British Journal of Cancer vol. 64 , ( 6 ) 1076 - 1082 .

Wright PA, Lemoine NR, Goretzki PE, Wyllie FS, Bond J, Hughes C, Röher HD, Williams ED et al. ( 1991 ) . Mutation of the p53 gene in a differentiated human thyroid carcinoma cell line, but not in primary thyroid tumours . Oncogene vol. 6 , ( 9 ) 1693 - 1697 .

Hall P, Ray A, Lemoine N, Midgley C, Krausz T, Lane D ( 1991 ) . p53 immunostaining as a marker of malignant disease in diagnostic cytopathology . The Lancet vol. 338 , ( 8765 )

Lemoine N, Jain S, Silvestre F, Lopes C, Hughes C, McLelland E, Gullick W, Filipe M ( 1991 ) . Amplification and overexpression of the EGF receptor and c-erbB-2 proto-oncogenes in human stomach cancer . British Journal of Cancer vol. 64 , ( 1 ) 79 - 83 .

Hall PA, Lemoine NR, Murphy G, Dowling RH ( 1991 ) . Molecular differences between human and experimental pancreaticobiliary diversion-induced rat pancreatic neoplasia . Gut vol. 32 , ( 5 )

Wright PA, Williams ED, Lemoine NR, Wynford-Thomas D ( 1991 ) . Radiation-associated and 'spontaneous' human thyroid carcinomas show a different pattern of ras oncogene mutation . Oncogene vol. 6 , ( 3 ) 471 - 473 .

Tuzi N, Venter D, Kumar S, Staddon S, Lemoine N, Gullick W ( 1991 ) . Expression of growth factor receptors in human brain tumours . British Journal of Cancer vol. 63 , ( 2 ) 227 - 233 .

Lemoine NR, Hall PA ( 1990 ) . Growth factors and oncogenes in pancreatic cancer . Best Practice & Research Clinical Gastroenterology vol. 4 , ( 4 ) 815 - 832 .

Lemoine NR, Staddon S, Bond J, Wyllie FS, Shaw JJ, Wynford-Thomas D ( 1990 ) . Partial transformation of human thyroid epithelial cells by mutant Ha-ras oncogene . Oncogene vol. 5 , ( 12 ) 1833 - 1837 .

Wynford-Thomas D, Bond JA, Wyllie FS, Burns JS, Williams ED, Jones T, Sheer D, Lemoine NR ( 1990 ) . Conditional Immortalization of Human Thyroid Epithelial Cells: A Tool for Analysis of Oncogene Action . Molecular and Cellular Biology vol. 10 , ( 10 ) 5365 - 5377 .

Lemoine NR, Staddon S, Dickson C, Barnes DM, Gullick WJ ( 1990 ) . Absence of activating transmembrane mutations in the c-erbB-2 proto-oncogene in human breast cancer . Oncogene vol. 5 , ( 2 ) 237 - 239 .

Lemoine NR, Wyllie FS, Lillehaug JR, Staddon SL, Hughes CM, Aasland R, Shaw J, Varhaug JE et al. ( 1990 ) . Absence of abnormalities of the c-erbB-1 and c-erbB-2 proto-oncogenes in human thyroid neoplasia . European Journal of Cancer vol. 26 , ( 7 ) 777 - 779 .

Lemoine N, Mayall E, Jones T, Sheer D, McDermid S, Kendall-Taylor P, Wynford-Thomas D ( 1989 ) . Characterisation of human thyroid epithelial cells immortalised in vitro by simian virus 40 DNA transfection . British Journal of Cancer vol. 60 , ( 6 ) 897 - 903 .

Wright P, Lemoine N, Mayall E, Wyllie F, Hughes D, Williams E, Wynford-Thomas D ( 1989 ) . Papillary and follicular thyroid carcinomas show a different pattern of ras oncogene mutation . British Journal of Cancer vol. 60 , ( 4 ) 576 - 577 .

Wyllie F, Lemoine N, Williams E, Wynford-Thomas D ( 1989 ) . Structure and expression of nuclear oncogenes in multi-stage thyroid tumorigenesis . British Journal of Cancer vol. 60 , ( 4 ) 561 - 565 .

Burns J, Lemoine L, Lemoine N, Williams E, Wynford-Thomas D ( 1989 ) . Thyroid epithelial cell transformation by a retroviral vector expressing SV40 large T . British Journal of Cancer vol. 59 , ( 5 ) 755 - 760 .

Stratton MR, Marshall CJ, Cooper CS, Nag A, Jones J, Smith R, Wright P, Lemoine N et al. ( 1989 ) . ALTERED c-H-ras GENE IN NON-NEOPLASTIC TISSUE . The Lancet vol. 333 , ( 8639 ) 668 - 669 .

Lemoine NR, Mayall ES, Wyllie FS, Williams ED, Goyns M, Stringer B, Wynford-Thomas D ( 1989 ) . High frequency of ras oncogene activation in all stages of human thyroid tumorigenesis . Oncogene vol. 4 , ( 2 ) 159 - 164 .

Lemoine NR, Mayall ES, Williams ED, Thurston V, Wynford-Thomas D ( 1988 ) . Agent-specific ras oncogene activation in rat thyroid tumours . Oncogene vol. 3 , ( 5 ) 541 - 544 .

Lemoine NR, Mayall ES, Wyllie FS, Farr CJ, Hughes D, Padua RA, Thurston V, Williams ED et al. ( 1988 ) . Activated ras oncogenes in human thyroid cancers . Cancer Research vol. 48 , ( 16 ) 4459 - 4463 .

Wyllie F, Wynford-Thomas V, Lemoine N, Williams G, Williams E, Wynford-Thomas D ( 1988 ) . Ha-ras restriction fragment length polymorphisms in colorectal cancer . British Journal of Cancer vol. 57 , ( 2 ) 135 - 138 .

Lemoine N, Wynford-Thomas V, Wynford-Thomas D ( 1987 ) . Optimisation of conditions for detection of activated oncogenes by transfection of NIH 3T3 cells . British Journal of Cancer vol. 55 , ( 6 ) 639 - 642 .

Hall PA, Lemoine NR ( 1986 ) . Comparison of manual data coding errors in two hospitals . Journal of Clinical Pathology vol. 39 , ( 6 )

Lemoine NR, Ryan JF, Cox EL, Mayston V, Revell PA, Swash M ( 1986 ) . Immunohistochemical analysis of mononuclear cell subsets in inflammatory and non-inflammatory myopathies . Journal of Clinical Pathology vol. 39 , ( 3 )

WRIGHT S, LEMOINE NR, LEIGH IM ( 1986 ) . Woolly hair naevi with systematized linear epidermal naevus . Clinical and Experimental Dermatology vol. 11 , ( 2 ) 179 - 182 .