Publications: Prof Yongjie Lu
Lu M, Gong X, Zhang Y-M, Guo Y-W, Zhu Y, Zeng X-B, Gao J-H, Liu L-M et al.
(
2024
)
.
Platelets promote primary hepatocellular carcinoma metastasis through TGF-β1-mediated cancer cell autophagy
.
Cancer Letters
vol.
600
,
Woodcock DJ, Sahli A, Teslo R, Bhandari V, Gruber AJ, Ziubroniewicz A, Gundem G, Xu Y et al.
(
2024
)
.
Genomic evolution shapes prostate cancer disease type
.
Cell Genomics
vol.
4
,
(
3
)
Yarmolinsky J, Robinson JW, Mariosa D, Karhunen V, Huang J, Dimou N, Murphy N, Burrows K et al.
(
2024
)
.
Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysis
.
EBioMedicine
vol.
100
,
Gao J-H, He A-D, Liu L-M, Zhou Y-J, Guo Y-W, Lu M, Zeng X-B, Gong X et al.
(
2024
)
.
Direct interaction of platelet with tumor cell aggravates hepatocellular carcinoma metastasis by activating TLR4/ADAM10/CX3cl1 axis
.
Cancer Letters
vol.
585
,
Watts EL, Gonzales TI, Strain T, Saint-Maurice PF, Bishop DT, Chanock SJ, Johansson M, Keku TO et al.
(
2023
)
.
Observational and genetic associations between cardiorespiratory fitness and cancer: a UK Biobank and international consortia study
.
British Journal of Cancer
vol.
130
,
(
1
)
114
-
124
.
Wang A, Shen J, Rodriguez AA, Saunders EJ, Chen F, Janivara R, Darst BF, Sheng X et al.
(
2023
)
.
Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants
.
Nature Genetics
vol.
55
,
(
12
)
2065
-
2074
.
Al-Hammouri T, Almeida-Magana R, Lawrence R, Duffy T, White L, Burke E, Kudahetti S, Collins J et al.
(
2023
)
.
Protocol for a prospective study evaluating circulating tumour cells status to predict radical prostatectomy treatment failure in localised prostate cancer patients (C-ProMeta-1)
.
BMC Cancer
vol.
23
,
(
1
)
Darst BF, Shen J, Madduri RK, Rodriguez AA, Xiao Y, Sheng X, Saunders EJ, Dadaev T et al.
(
2023
)
.
Evaluating approaches for constructing polygenic risk scores for prostate cancer in men of African and European ancestry
.
American Journal of Human Genetics
vol.
110
,
(
7
)
1200
-
1206
.
Lawrence R, Watters M, Davies CR, Pantel K, Lu Y-J
(
2023
)
.
Circulating tumour cells for early detection of clinically relevant cancer
.
Nature Reviews Clinical Oncology
vol.
20
,
(
7
)
487
-
500
.
Yarmolinsky J, Bouras E, Constantinescu A, Burrows K, Bull CJ, Vincent EE, Martin RM, Dimopoulou O et al.
(
2023
)
.
Genetically proxied glucose-lowering drug target perturbation and risk of cancer: a Mendelian randomisation analysis
.
Diabetologia
vol.
66
,
(
8
)
1481
-
1500
.
Davies CR, Guo T, Burke E, Stankiewicz E, Xu L, Mao X, Scandura G, Rajan P et al.
(
2023
)
.
The potential of using circulating tumour cells and their gene expression to predict docetaxel response in metastatic prostate cancer
.
Frontiers in Oncology
vol.
12
,
Zhang Y, Wang K, Yang D, Liu F, Xu X, Feng Y, Wang Y, Zhu S et al.
(
2022
)
.
Hsa_circ_0094606 promotes malignant progression of prostate cancer by inducing M2 polarization of macrophages through PRMT1-mediated arginine methylation of ILF3
.
Carcinogenesis
vol.
44
,
(
1
)
15
-
28
.
Chang Q, Chen P, Yin J, Liang G, Dai Y, Guan Y, Chen Y, Zhao Y et al.
(
2022
)
.
Discovery and validation of bladder cancer related excreted nucleosides biomarkers by dilution approach in cell culture supernatant and urine using UHPLC-MS/MS
.
Journal of Proteomics
vol.
270
,
Buhigas C, Warren AY, Leung W-K, Whitaker HC, Luxton HJ, Hawkins S, Kay J, Butler A et al.
(
2022
)
.
The architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates
.
Molecular Cancer
vol.
21
,
(
1
)
Burns D, Anokian E, Saunders EJ, Bristow RG, Fraser M, Reimand J, Schlomm T, Sauter G et al.
(
2022
)
.
Rare Germline Variants Are Associated with Rapid Biochemical Recurrence After Radical Prostate Cancer Treatment: A Pan Prostate Cancer Group Study
.
European Urology
vol.
82
,
(
2
)
201
-
211
.
Xue X, Dong L, Burke E, Xue L, Lu Y-J
(
2022
)
.
The interaction of p53 and DNA repair gene mutations and their impact on tumor mutation burden and immune response in human malignancies
.
American Journal of Cancer Research
vol.
12
,
(
4
)
1866
-
1883
.
Berstein FM, McCartney DL, Lu AT, Tsilidis KK, Bouras E, Haycock P, Burrows K, Phipps AI et al.
(
2022
)
.
Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study
.
eLife
vol.
11
,
Zhang Y, Hollis D, Ross R, Snow T, Terrill NJ, Lu Y, Wang W, Connelly J et al.
(
2022
)
.
Investigating the Fibrillar Ultrastructure and Mechanics in Keloid Scars Using In Situ Synchrotron X-ray Nanomechanical Imaging
.
Materials (Basel)
vol.
15
,
(
5
)
Huynh-Le M-P, Karunamuni R, Fan CC, Asona L, Thompson WK, Martinez ME, Eeles RA, Kote-Jarai Z et al.
(
2022
)
.
Prostate cancer risk stratification improvement across multiple ancestries with new polygenic hazard score
.
Prostate Cancer and Prostatic Diseases
vol.
25
,
(
4
)
755
-
761
.
Guo Y, Yin J, Dai Y, Guan Y, Chen P, Chen Y, Huang C, Lu Y-J et al.
(
2021
)
.
A Novel CpG Methylation Risk Indicator for Predicting Prognosis in Bladder Cancer
.
Frontiers in Cell and Developmental Biology
vol.
9
,
Martin K, Zhang T, Lin T-T, Habowski AN, Zhao R, Tsai C-F, Chrisler WB, Sontag RL et al.
(
2021
)
.
Facile One-Pot Nanoproteomics for Label-Free Proteome Profiling of 50–1000 Mammalian Cells
.
Journal of Proteome Research
vol.
20
,
(
9
)
4452
-
4461
.
Huynh-Le M-P, Fan CC, Karunamuni R, Thompson WK, Martinez ME, Eeles RA, Kote-Jarai Z, Muir K et al.
(
2021
)
.
Polygenic hazard score is associated with prostate cancer in multi-ethnic populations
.
Nature Communications
vol.
12
,
(
1
)
Conti DV, Darst BF, Moss LC, Saunders EJ, Sheng X, Chou A, Schumacher FR, Olama AAA et al.
(
2021
)
.
Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
.
Nature Genetics
vol.
53
,
(
3
)
413
-
413
.
Marzec J, Ross-Adams H, Pirrò S, Wang J, Zhu Y, Mao X, Gadaleta E, Ahmad AS et al.
(
2021
)
.
The Transcriptomic Landscape of Prostate Cancer Development and Progression: An Integrative Analysis
.
Cancers
vol.
13
,
(
2
)
Guo T, Wang Y, Jia J, Mao X, Stankiewicz E, Scandura G, Burke E, Xu L et al.
(
2021
)
.
The Identification of Plasma Exosomal miR-423-3p as a Potential Predictive Biomarker for Prostate Cancer Castration-Resistance Development by Plasma Exosomal miRNA Sequencing
.
Frontiers in Cell and Developmental Biology
vol.
8
,
Conti DV, Darst BF, Moss LC, Saunders EJ, Sheng X, Chou A, Schumacher FR, Olama AAA et al.
(
2021
)
.
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
.
Nature Genetics
vol.
53
,
(
1
)
65
-
75
.
Bailey MH, Meyerson WU, Dursi LJ, Wang L-B, Dong G, Liang W-W, Weerasinghe A, Li S et al.
(
2020
)
.
Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
.
Nature Communications
vol.
11
,
(
1
)
Bailey MH, Meyerson WU, Dursi LJ, Wang L-B, Dong G, Liang W-W, Weerasinghe A, Li S et al.
(
2020
)
.
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
.
Nature Communications
vol.
11
,
(
1
)
Li CH, Prokopec SD, Sun RX, Yousif F, Schmitz N, Boutros PC
(
2020
)
.
Sex differences in oncogenic mutational processes
.
Nature Communications
vol.
11
,
(
1
)
Wu L, Yang Y, Guo X, Shu X-O, Cai Q, Shu X, Li B, Tao R et al.
(
2020
)
.
An integrative multi-omics analysis to identify candidate DNA methylation biomarkers related to prostate cancer risk
.
Nature Communications
vol.
11
,
(
1
)
Tilley W, Risbridger GP, Clements J, Horvath L, Taylor R, Hayes V, Butler L, Yeadon T et al.
(
2020
)
.
Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and lifespan
.
Nature Communications
vol.
11
,
(
1
)
(
2020
)
.
Pan-cancer analysis of whole genomes
.
Nature
vol.
578
,
(
7793
)
82
-
93
.
Xu L, Mao X, Grey A, Scandura G, Guo T, Burke E, Marzec J, Abdu S et al.
(
2020
)
.
Reply by Authors
.
The Journal of urology
vol.
203
,
(
1
)
81
-
82
.
Stankiewicz E, Guo T, Mao X, Lu YJ
(
2019
)
.
Fluorescence in situ hybridization and rehybridization using bacterial artificial chromosome probes
.
Methods in Molecular Biology
vol.
2054
,
243
-
261
.
Guo T, Stankiewicz E, Mao X, Lu YJ
(
2019
)
.
The isolation and analysis of circulating tumor cells
.
Methods in Molecular Biology
vol.
2054
,
115
-
128
.
Xu L, Mao X, Grey A, Scandura G, Guo T, Burke E, Marzec J, Abdu S et al.
(
2019
)
.
Noninvasive Detection of Clinically Significant Prostate Cancer Using Circulating Tumor Cells
.
The Journal of Urology
vol.
203
,
101097JU000000000000
-
101097JU000000000000
.
Loveday C, Sud A, Litchfield K, Levy M, Holroyd A, Broderick P, Kote‐Jarai Z, Dunning AM et al.
(
2019
)
.
Runs of homozygosity and testicular cancer risk
.
Andrology
vol.
7
,
(
4
)
555
-
564
.
Guo T, Wang Y, Mao X, Xu L, Marzec J, Burke E, Scandura G, Stankiewicz E et al.
(
2019
)
.
Abstract 2580: Investigation of plasma exosomal miRNA as a biomarker and its potential function in prostate cancer castration resistant development
.
Cancer Research
.
vol.
79
,
2580
-
2580
.
Wu L, Wang J, Cai Q, Cavazos TB, Emami NC, Long J, Shu X-O, Lu Y et al.
(
2019
)
.
Identification of Novel Susceptibility Loci and Genes for Prostate Cancer Risk: A Transcriptome-Wide Association Study in Over 140,000 European Descendants
.
Cancer Research
vol.
79
,
(
13
)
3192
-
3204
.
Song D, Powles T, Shi L, Zhang L, Ingersoll MA, Lu Y
(
2019
)
.
Bladder cancer, a unique model to understand cancer immunity and develop immunotherapy approaches
.
The Journal of Pathology
vol.
249
,
(
2
)
151
-
165
.
Law PJ, Timofeeva M, Fernandez-Rozadilla C, Broderick P, Studd J, Fernandez-Tajes J, Farrington S, Svinti V et al.
(
2019
)
.
Association analyses identify 31 new risk loci for colorectal cancer susceptibility
.
Nature Communications
vol.
10
,
(
1
)
Yeste-Velasco M, Guo T, Mao X, Stankiewicz E, Scandura G, Li H, Wang CS, Kudahetti S et al.
(
2019
)
.
The potential of brentuximab vedotin, alone or in combination with current clinical therapies, in the treatment of testicular germ cell tumors
.
American Journal of Cancer Research
vol.
9
,
(
5
)
855
-
871
.
Matejcic M, Saunders EJ, Dadaev T, Brook MN, Wang K, Sheng X, Olama AAA, Schumacher FR et al.
(
2019
)
.
Author Correction: Germline variation at 8q24 and prostate cancer risk in men of European ancestry
.
Nature Communications
vol.
10
,
(
1
)
Schumacher FR, Olama AAA, Berndt SI, Benlloch S, Ahmed M, Saunders EJ, Dadaev T, Leongamornlert D et al.
(
2019
)
.
Author Correction: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci
.
Nature Genetics
vol.
51
,
(
2
)
363
-
363
.
Mancuso N, Gayther S, Gusev A, Zheng W, Penney KL, Kote-Jarai Z, Eeles R, Freedman M et al.
(
2019
)
.
Author Correction: Large-scale transcriptome-wide association study identifies new prostate cancer risk regions
.
Nature Communications
vol.
10
,
(
1
)
Adams C, Richmond RC, Ferreira DLS, Spiller W, Tan VY, Zheng J, Wurtz P, Donovan JL et al.
(
2019
)
.
Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study
.
Cancer Epidemiology Biomarkers & Prevention
vol.
28
,
(
1
)
Xu L, Bastus NC, Lu Y-J
(
2019
)
.
Chapter 15 Sequencing a Single Circulating Tumor Cell for Genomic Assessment
.
Oncogenomics
,
Elsevier
Xue X, Shi F, Dong L, Rong L, Li L, Zheng B, Liu X, Liu W et al.
(
2019
)
.
Predisposition of Adrenocortical Carcinoma by Loss of Function of Mismatch Repair Genes and The Role of TP53 In Cancer Development
.
LABORATORY INVESTIGATION
.
vol.
99
,
Vijayakrishnan J, Studd J, Broderick P, Kinnersley B, Holroyd A, Law PJ, Kumar R, Allan JM et al.
(
2018
)
.
Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia
.
Nature Communications
vol.
9
,
(
1
)
Guo T, Wang Y, Mao X, Xu L, Marzec J, Burke E, Shaw G, Hines J et al.
(
2018
)
.
Investigation of exosomal miRNA as biomarker for prostate cancer castration resistance development
.
BRITISH JOURNAL OF CANCER
.
Conference:
NCRI Cancer Conferences
vol.
119
,
32
-
32
.
Matejcic M, Saunders EJ, Dadaev T, Brook MN, Wang K, Sheng X, Olama AAA, Schumacher FR et al.
(
2018
)
.
Germline variation at 8q24 and prostate cancer risk in men of European ancestry
.
Nature Communications
vol.
9
,
(
1
)
Mancuso N, Gayther S, Gusev A, Zheng W, Penney KL, Kote-Jarai Z, Eeles R, Freedman M et al.
(
2018
)
.
Large-scale transcriptome-wide association study identifies new prostate cancer risk regions
.
Nature Communications
vol.
9
,
(
1
)
Went M, Sud A, Försti A, Halvarsson B-M, Weinhold N, Kimber S, van Duin M, Thorleifsson G et al.
(
2018
)
.
Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma
.
Nature Communications
vol.
9
,
(
1
)
Adimonye A, Stankiewicz E, Touche SL, Kudahetti S, Tinwell B, Corbishley C, Lu Y-J, Watkin N et al.
(
2018
)
.
The Prognostic Value of PIK3CA Copy Number Gain in Penile Cancer
.
Urology
Matejcic M, Saunders EJ, Dadaev T, Brook M, Olama AAA, Schumacher FR, Berndt SI, Benlloch S et al.
(
2018
)
.
Abstract 227: Germline variation at 8q24 and prostate cancer risk in men of European ancestry
.
Cancer Research
.
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78
,
227
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227
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Adimonye A, Stankiewicz E, La-Touche S, Kudahetti S, Trevisan G, Tinwell B, Corbishley C, Lu Y-J et al.
(
2018
)
.
PIK3CA copy number aberration and activation of the PI3K-AKT-mTOR pathway in varied disease states of penile cancer
.
PLoS ONE
vol.
13
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(
6
)
e0198905
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e0198905
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Schumacher FR, Al Olama AA, Berndt SI, Benlloch S, Ahmed M, Saunders EJ, Dadaev T, Leongamornlert D et al.
(
2018
)
.
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci
.
Nature Genetics
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50
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7
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928
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936
.
Dadaev T, Saunders EJ, Newcombe PJ, Anokian E, Leongamornlert DA, Brook MN, Cieza-Borrella C, Mijuskovic M et al.
(
2018
)
.
Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants
.
Nature Communications
vol.
9
,
(
1
)
Lin H-Y, Huang P-Y, Chen D-T, Tung H-Y, Sellers TA, Pow-Sang JM, Eeles R, Easton D et al.
(
2018
)
.
AA9int: SNP interaction pattern search using non-hierarchical additive model set
.
Bioinformatics
vol.
34
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(
24
)
4141
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4150
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Wedge DC, Gundem G, Mitchell T, Woodcock DJ, Martincorena I, Ghori M, Zamora J, Butler A et al.
(
2018
)
.
Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets
.
Nature Genetics
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50
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5
)
682
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692
.
Adimonye A, Stankiewicz E, Kudahetti S, Trevisan G, Tinwell B, Corbishley C, Lu Y-J, Watkin N et al.
(
2018
)
.
Analysis of the PI3K-AKT-mTOR pathway in penile cancer: evaluation of a therapeutically targetable pathway
.
Oncotarget
vol.
9
,
(
22
)
16074
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16086
.
Aguirre-Hernández C, Maya-Pineda H, Millán JS, Man YKS, Lu Y-J, Halldén G
(
2018
)
.
Sensitisation to mitoxantrone-induced apoptosis by the oncolytic adenovirus Ad∆∆ through Bcl-2-dependent attenuation of autophagy
.
Oncogenesis
vol.
7
,
(
1
)
Xu L, Bastus NC, Lu YJ
(
2018
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Sequencing a single circulating tumor cell for genomic assessment
.
Oncogenomics: From Basic Research to Precision Medicine
,
Sud A, Thomsen H, Law PJ, Försti A, Filho MIDS, Holroyd A, Broderick P, Orlando G et al.
(
2017
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Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility
.
Nature Communications
vol.
8
,
(
1
)
Aguirre-Hernandez C, Maya-Pineda H, Millan JS, Man YKS, Lu YJ, Hallden G
(
2017
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.
Sensitisation to mitoxantrone-induced apoptosis by the oncolytic adenovirus Ad Delta Delta through Bcl-2-dependent attenuation of autophagy
.
HUMAN GENE THERAPY
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Conference:
ESGCT workshop Croatia
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28
,
A26
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A26
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Camacho N, Van Loo P, Edwards S, Kay JD, Matthews L, Haase K, Clark J, Dennis N et al.
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2017
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Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data
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PLoS Genet
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13
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9
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e1007001
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e1007001
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Stankiewicz E, Xueying M, Mangham DC, Xu L, Yeste-Velasco M, Fisher G, North B, Chaplin T et al.
(
2017
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Identification of FBXL4 as a Metastasis Associated Gene in Prostate Cancer
.
Scientific Reports
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5124
,
Xu L, Mao X, Guo T, Chan PY, Shaw G, Hines J, Stankiewicz E, Wang Y et al.
(
2017
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The novel association of circulating tumor cells and circulating megakaryocytes with prostate cancer prognosis
.
Clin Cancer Res
Adimonye A, Stankiewicz E, Nicholson S, Hall E, Kudahetti S, Rajab R, Corbishley C, Lu Y-J et al.
(
2017
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709 PIK3CA copy number aberration and activation of the PI3K-AKT-mTOR pathway in evolving disease states of penile cancer
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European Urology Open Science
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16
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3
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e1228
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e1229
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Lin H-Y, Chen D-T, Huang P-Y, Liu Y-H, Ochoa A, Zabaleta J, Mercante DE, Fang Z et al.
(
2016
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SNP interaction pattern identifier (SIPI): an intensive search for SNP–SNP interaction patterns
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Bioinformatics
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33
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6
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822
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833
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Berney DM, Lu Y, Shamash J, Idrees M
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2016
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Postchemotherapy changes in testicular germ cell tumours: biology and morphology
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Histopathology
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70
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1
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26
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39
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Behjati S, Gundem G, Wedge DC, Roberts ND, Tarpey PS, Cooke SL, Van Loo P, Alexandrov LB et al.
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2016
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Mutational signatures of ionizing radiation in second malignancies
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Nature Communications
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7
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Article
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1
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8
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Mao X, Luo F, Boyd LK, Zhou B, Zhang Y, Stankiewicz E, Marzec J, Vasiljevic N et al.
(
2016
)
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NKAIN2 functions as a novel tumor suppressor in prostate cancer
.
Oncotarget
Imrali A, Mao X, Yeste-Velasco M, Shamash J, Lu Y
(
2016
)
.
Rapamycin inhibits prostate cancer cell growth through cyclin D1 and enhances the cytotoxic efficacy of cisplatin
.
American Journal of Cancer Research
vol.
6
,
(
8
)
1772
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1784
.
Jiang H, Mao X, Huang X, Zhao J, Wang L, Xu J, Zhang H, Lu Y et al.
(
2016
)
.
Erratum to: TMPRSS2:ERG fusion gene occurs less frequently in Chinese patients with prostate cancer
.
Tumour Biol
vol.
37
,
(
10
)
14331
-
14331
.
Stankiewicz E, Mao X, Mangham DC, Xu L, Fisher G, North B, Moller H, Scardino P et al.
(
2016
)
.
Identification of FBXL4 as a bone metastasis-associated gene in prostate cancer
.
Scientific Reports
vol.
7
,
Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, Chu S, Czajkowski J, Esko T et al.
(
2016
)
.
Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
.
PLoS Genet
vol.
12
,
(
6
)
e1006166
-
e1006166
.
Jiang H, Mao X, Huang X, Zhao J, Wang L, Xu J, Zhang H, Lu Y et al.
(
2016
)
.
TMPRSS2:ERG fusion gene occurs less frequently in Chinese patients with prostate cancer
.
Tumor Biology
vol.
37
,
(
9
)
12397
-
12402
.
Wang Y, Shao N, Mao X, Zhu M, Fan W, Shen Z, Xiao R, Wang C et al.
(
2016
)
.
MiR-4638-5p inhibits castration resistance of prostate cancer through repressing kidins220 expression and PI3K/AKT pathway activity
.
Oncotarget
vol.
7
,
(
30
)
47444
-
47464
.
Adimonve A, Stankiewicz E, Kudahetti S, Rajab R, Corbishley C, Lu Y-J, Watkin N, Berney D
(
2016
)
.
238 PIK3CA gene copy number and mRNA expression in invasive penile cancer
.
European Urology Open Science
vol.
15
,
(
3
)
Marzec J, Mao X, Li M, Wang M, Feng N, Gou X, Wang G, Sun Z et al.
(
2016
)
.
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