Publications: Prof Thomas MacDonald

Pavlidis P, Tsakmaki A, Pantazi E, Li K, Cozzetto D, Digby- Bell J, Yang F, Lo JW et al. ( 2022 ) . Interleukin-22 regulates neutrophil recruitment in ulcerative colitis and is associated with resistance to ustekinumab therapy . Nature Communications vol. 13 , ( 1 )

Omer OS, Hertweck A, Roberts LB, Lo JW, Clough JN, Jackson I, Pantazi ED, Irving PM et al. ( 2022 ) . Cyclin-dependent Kinase 9 as a Potential Target for Anti-TNF-resistant Inflammatory Bowel Disease . Cellular and Molecular Gastroenterology and Hepatology vol. 14 , ( 3 ) 625 - 641 .

Roberts KJ, Cubitt MF, Carlton TM, Rodrigues-Duarte L, Maggiore L, Chai R, Clare S, Harcourt K et al. ( 2021 ) . Preclinical development of a bispecific TNFα/IL-23 neutralising domain antibody as a novel oral treatment for inflammatory bowel disease . Scientific Reports vol. 11 , ( 1 )

Papa-Gobbi R, Muglia CI, Rocca A, Curciarello R, Sambuelli AM, Yantorno M, Correa G, Morosi LG et al. ( 2021 ) . Spatiotemporal regulation of galectin-1-induced T-cell death in lamina propria from Crohn’s disease and ulcerative colitis patients . Apoptosis vol. 26 , ( 5-6 ) 323 - 337 .

Curciarello R, Sobande T, Jones S, Giuffrida P, Di Sabatino A, Docena GH, MacDonald TT, Kok K ( 2020 ) . Human Neutrophil Elastase Proteolytic Activity in Ulcerative Colitis Favors the Loss of Function of Therapeutic Monoclonal Antibodies . Journal of Inflammation Research vol. 13 , 233 - 243 .

MacDonald TT, Di Sabatino A ( 2020 ) . T lymphocyte populations within the lamina propria . Principles of Mucosal Immunology , Taylor & Francis

Mares A, Miah AH, Smith IED, Rackham M, Thawani AR, Cryan J, Haile PA, Votta BJ et al. ( 2020 ) . Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2 . Communications Biology vol. 3 , ( 1 )

De la Fuente M, MacDonald TT, Hermoso MA ( 2019 ) . Editorial: Intestinal Homeostasis and Disease: A Complex Partnership Between Immune Cells, Non-Immune Cells, and the Microbiome . Frontiers in Immunology vol. 10 ,

Powell N, Pantazi E, Pavlidis P, Tsakmaki A, Li K, Yang F, Parker A, Pin C et al. ( 2019 ) . Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells . Gut vol. 69 , ( 3 )

Haddow JB, Musbahi O, MacDonald TT, Knowles CH ( 2019 ) . Comparison of cytokine and phosphoprotein profiles in idiopathic and Crohn’s disease-related perianal fistula . World Journal of Gastrointestinal Pathophysiology vol. 10 , ( 4 ) 42 - 53 .

Nurbhai S, Roberts KJ, Carlton TM, Maggiore L, Cubitt MF, Ray KP, Reckless J, Mohammed H et al. ( 2019 ) . Oral Anti-Tumour Necrosis Factor Domain Antibody V565 Provides High Intestinal Concentrations, and Reduces Markers of Inflammation in Ulcerative Colitis Patients . Scientific Reports vol. 9 , ( 1 )

Haile PA, Casillas LN, Votta BJ, Wang GZ, Charnley AK, Dong X, Bury MJ, Romano JJ et al. ( 2019 ) . Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2‑((4-(Benzo[d]­thiazol-5-ylamino)-6‑(tert-butylsulfonyl)­quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases . Journal of Medicinal Chemistry vol. 62 , ( 14 ) 6482 - 6494 .

Sun D, Stopka-Farooqui U, Barry S, Aksoy E, Parsonage G, Vossenkämper A, Capasso M, Wan X et al. ( 2019 ) . Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation . Cell Reports vol. 27 , ( 5 ) 1461 - 1471.e4 .

Reisdorf WC, Xie Q, Zeng X, Xie W, Rajpal N, Hoang B, Burgert ME, Kumar V et al. ( 2019 ) . Preclinical evaluation of EPHX2 inhibition as a novel treatment for inflammatory bowel disease . PLOS ONE vol. 14 , ( 4 )

Belarif L, Danger R, Kermarrec L, Nerrière-Daguin V, Pengam S, Durand T, Mary C, Kerdreux E et al. ( 2019 ) . IL-7 receptor influences anti-TNF responsiveness and T cell gut homing in inflammatory bowel disease . Journal of Clinical Investigation vol. 129 , ( 5 ) 1910 - 1925 .

Garrido-Mesa N, Schroeder J-H, Stolarczyk E, Gallagher AL, Lo JW, Bailey C, Campbell L, Sexl V et al. ( 2018 ) . T-bet controls intestinal mucosa immune responses via repression of type 2 innate lymphoid cell function . Mucosal Immunology vol. 12 , ( 1 ) 51 - 63 .

Laudisi F, Di Fusco D, Dinallo V, Stolfi C, Di Grazia A, Marafini I, Colantoni A, Ortenzi A et al. ( 2018 ) . The Food Additive Maltodextrin Promotes Endoplasmic Reticulum Stress–Driven Mucus Depletion and Exacerbates Intestinal Inflammation . Cellular and Molecular Gastroenterology and Hepatology vol. 7 , ( 2 ) 457 - 473 .

Crowe JS, Roberts KJ, Carlton TM, Maggiore L, Cubitt MF, Clare S, Harcourt K, Reckless J et al. ( 2018 ) . Preclinical Development of a Novel, Orally-Administered Anti-Tumour Necrosis Factor Domain Antibody for the Treatment of Inflammatory Bowel Disease . Scientific Reports vol. 8 , ( 1 )

Díaz-Jiménez D, Núñez L, De la Fuente M, Dubois-Camacho K, Sepúlveda H, Montecino M, Torres-Riquelme A, García-González P et al. ( 2017 ) . A functional IL1RL1 variant regulates corticosteroid-induced sST2 expression in ulcerative colitis . Scientific Reports vol. 7 , ( 1 )

Curciarello R, Docena GH, MacDonald TT ( 2017 ) . The Role of Cytokines in the Fibrotic Responses in Crohn's Disease . Frontiers in Medicine vol. 4 , 126 - 126 .

Powell N, MacDonald TT ( 2017 ) . Recent advances in gut immunology . Parasite Immunology vol. 39 , ( 6 )

Biancheri P, MacDonald TT ( 2017 ) . Matrix Metalloproteinases . Crohn's Disease and Ulcerative Colitis , Springer Nature

Harris PA, Berger SB, Jeong JU, Nagilla R, Bandyopadhyay D, Campobasso N, Capriotti CA, Cox JA et al. ( 2017 ) . Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases . J Med Chem vol. 60 , ( 4 ) 1247 - 1261 .

Bron PA, Kleerebezem M, Brummer R-J, Cani PD, Mercenier A, MacDonald TT, Garcia-Ródenas CL, Wells JM ( 2017 ) . Can probiotics modulate human disease by impacting intestinal barrier function? . Br J Nutr vol. 117 , ( 1 ) 93 - 107 .

Foster M, Biancheri P, Fyfe M, MacDonald T, Rowley A, Sirohi S, Solanke Y, Webber S et al. ( 2017 ) . The pharmacological profile of TOP1288, a narrow spectrum kinase inhibitor in clinical development as an anti-inflammatory treatment for ulcerative colitis . JOURNAL OF CROHNS & COLITIS . vol. 11 , S95 - S95 .

Wells JM, Brummer RJ, Derrien M, MacDonald TT, Troost F, Cani PD, Theodorou V, Dekker J et al. ( 2016 ) . Homeostasis of the gut barrier and potential biomarkers . AJP Gastrointestinal and Liver Physiology vol. 312 , ( 3 ) g171 - g193 .

König J, Wells J, Cani PD, García-Ródenas CL, MacDonald T, Mercenier A, Whyte J, Troost F et al. ( 2016 ) . Human Intestinal Barrier Function in Health and Disease . Clinical and Translational Gastroenterology vol. 7 , ( 10 )

Muthas D, Reznichenko A, Balendran CA, Böttcher G, Clausen IG, Kärrman Mårdh C, Ottosson T, Uddin M et al. ( 2016 ) . Neutrophils in ulcerative colitis: a review of selected biomarkers and their potential therapeutic implications . Scand J Gastroenterol vol. 52 , ( 2 ) 125 - 135 .

Giles EM, Sanders TJ, McCarthy NE, Lung J, Pathak M, MacDonald TT, Lindsay JO, Stagg AJ ( 2016 ) . Regulation of human intestinal T-cell responses by type 1 interferon-STAT1 signaling is disrupted in inflammatory bowel disease . Mucosal Immunology vol. 10 , ( 1 ) 184 - 193 .

Haile PA, Votta BJ, Marquis RW, Bury MJ, Mehlmann JF, Singhaus R, Charnley AK, Lakdawala AS et al. ( 2016 ) . The Identification and Pharmacological Characterization of 6-( tert -Butylsulfonyl)- N -(5-fluoro-1 H -indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase . Journal of Medicinal Chemistry vol. 59 , ( 10 ) 4867 - 4880 .

Biancheri P, Foster MR, Fyfe MCT, MacDonald TT, Sirohi S, Solanke Y, Wood E, Rowley A et al. ( 2016 ) . Effect of Narrow Spectrum Versus Selective Kinase Inhibitors on the Intestinal Proinflammatory Immune Response in Ulcerative Colitis . Inflammatory Bowel Diseases vol. 22 , ( 6 ) 1306 - 1315 .

Biancheri P, Di Sabatino A, Rescigno M, Giuffrida P, Fornasa G, Tsilingiri K, Pender SLF, Papadia C et al. ( 2015 ) . Abnormal thymic stromal lymphopoietin expression in the duodenal mucosa of patients with coeliac disease . Gut vol. 65 , ( 10 )

De la Fuente M, MacDonald TT, Hermoso MA ( 2015 ) . The IL-33/ST2 axis: Role in health and disease . Cytokine & Growth Factor Reviews vol. 26 , ( 6 ) 615 - 623 .

Biancheri P, Brezski RJ, Di Sabatino A, Greenplate AR, Soring KL, Corazza GR, Kok KB, Rovedatti L et al. ( 2015 ) . Proteolytic Cleavage and Loss of Function of Biologic Agents That Neutralize Tumor Necrosis Factor in the Mucosa of Patients With Inflammatory Bowel Disease . Gastroenterology vol. 149 , ( 6 ) 1564 - 1574.e3 .

De Simone V, Franzè E, Ronchetti G, Colantoni A, Fantini MC, Di Fusco D, Sica GS, Sileri P et al. ( 2015 ) . Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth . Oncogene vol. 34 , ( 27 ) 3493 - 3503 .

Goldberg R, Prescott N, Lord GM, MacDonald TT, Powell N ( 2015 ) . The unusual suspects—innate lymphoid cells as novel therapeutic targets in IBD . Nature Reviews Gastroenterology & Hepatology vol. 12 , ( 5 ) 271 - 283 .

Powell N, Lo JW, Biancheri P, Vossenkämper A, Pantazi E, Walker AW, Stolarczyk E, Ammoscato F et al. ( 2015 ) . Interleukin 6 Increases Production of Cytokines by Colonic Innate Lymphoid Cells in Mice and Patients With Chronic Intestinal Inflammation . Gastroenterology vol. 149 , ( 2 ) 456 - 467.e15 .

Biancheri P, Di Sabatino A, Curciarello R, Ammoscato F, Corazza GR, Lindsay JO, MacDonald TT ( 2015 ) . Mo1724 Interleukin-17A Homodimer Reduces Pro-Inflammatory Cytokine Production by Inflammatory Bowel Disease Mucosa Cultured Ex Vivo . Gastroenterology vol. 148 , ( 4 ) s - 695 .

De Simone V, Ronchetti G, Franzè E, Colantoni A, Ortenzi A, Fantini MC, Rizzo A, Sica GS et al. ( 2015 ) . Interleukin-21 sustains inflammatory signals that contribute to sporadic colon tumorigenesis . Oncotarget vol. 6 , ( 12 ) 9908 - 9923 .

Canavan JB, Scottà C, Vossenkämper A, Goldberg R, Elder MJ, Shoval I, Marks E, Stolarczyk E et al. ( 2015 ) . Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease . Gut vol. 65 , ( 4 )

Di Sabatino A, Giuffrida P, Fornasa G, Salvatore C, Broglia F, Pasini A, Ammoscato F, Rescigno M et al. ( 2015 ) . THYMIC STROMAL LYMPHOPOIETIN MODULATES TISSUE REMODELLING AND REPAIR IN NORMAL AND INFLAMED GUT . DIGESTIVE AND LIVER DISEASE . vol. 47 , E182 - E182 .

Caruso R, Marafini I, Franzè E, Stolfi C, Zorzi F, Monteleone I, Caprioli F, Colantoni A et al. ( 2014 ) . Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut . Mucosal Immunol vol. 7 , ( 6 ) 1467 - 1479 .

Nijhuis A, Biancheri P, Lewis A, Bishop CL, Giuffrida P, Chan C, Feakins R, Poulsom R et al. ( 2014 ) . In Crohn's disease fibrosis-reduced expression of the miR-29 family enhances collagen expression in intestinal fibroblasts . Clin Sci (Lond) vol. 127 , ( 5 ) 341 - 350 .

Vossenkämper A, Hundsrucker C, Page K, van Maurik A, Sanders TJ, Stagg AJ, Das L, MacDonald TT ( 2014 ) . A CD3-specific antibody reduces cytokine production and alters phosphoprotein profiles in intestinal tissues from patients with inflammatory bowel disease . Gastroenterology vol. 147 , ( 1 ) 172 - 183 .

Rizzo A, De Mare V, Rocchi C, Stolfi C, Colantoni A, Neurath MF, Macdonald TT, Pallone F et al. ( 2014 ) . Smad7 induces plasticity in tumor-infiltrating Th17 cells and enables TNF-alpha-mediated killing of colorectal cancer cells . Carcinogenesis vol. 35 , ( 7 ) 1536 - 1546 .

Cupi ML, Sarra M, Marafini I, Monteleone I, Franzè E, Ortenzi A, Colantoni A, Sica G et al. ( 2014 ) . Plasma cells in the mucosa of patients with inflammatory bowel disease produce granzyme B and possess cytotoxic activities . J Immunol vol. 192 , ( 12 ) 6083 - 6091 .

Giuffrida P, Biancheri P, MacDonald TT ( 2014 ) . Proteases and small intestinal barrier function in health and disease . Curr Opin Gastroenterol vol. 30 , ( 2 ) 147 - 153 .

Stolfi C, De Simone V, Colantoni A, Franzè E, Ribichini E, Fantini MC, Caruso R, Monteleone I et al. ( 2014 ) . A functional role for Smad7 in sustaining colon cancer cell growth and survival . Cell Death Dis vol. 5 , ( 2 )

Biancheri P, Di Sabatino A, Ammoscato F, Facciotti F, Caprioli F, Curciarello R, Hoque SS, Ghanbari A et al. ( 2014 ) . Absence of a role for interleukin-13 in inflammatory bowel disease . Eur J Immunol vol. 44 , ( 2 ) 370 - 385 .

Kok K, Curciarello R, Giuffrida P, Joshi N, Biancheri P, MacDonald T ( 2014 ) . P054 Interactions between neutrophil elastase and biologics in IBD . Journal of Crohn's and Colitis vol. 8 , ( Supplement_1 ) s85 - s85 .

Biancheri P, Giuffrida P, Docena GH, MacDonald TT, Corazza GR, Di Sabatino A ( 2014 ) . The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut . Cytokine Growth Factor Rev vol. 25 , ( 1 ) 45 - 55 .

Caruso R, Marafini I, Sedda S, Del Vecchio Blanco G, Giuffrida P, MacDonald TT, Corazza GR, Pallone F et al. ( 2014 ) . Analysis of the cytokine profile in the duodenal mucosa of refractory coeliac disease patients . CLINICAL SCIENCE vol. 126 , ( 5-6 ) 451 - 458 .

Brooke MA, Longhurst HJ, Plagnol V, Kirkby NS, Mitchell JA, Rüschendorf F, Warner TD, Kelsell DP et al. ( 2014 ) . Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-α . Gut vol. 63 , ( 1 ) 96 - 104 .

Curciarello R, Steele A, Cooper D, MacDonald TT, Kruidenier L, Kudo T ( 2014 ) . The role of Galectin-1 and Galectin-3 in the mucosal immune response to Citrobacter rodentium infection . PLoS One vol. 9 , ( 9 )

Biancheri P, Powell N, Monteleone G, Lord G, MacDonald TT ( 2013 ) . The challenges of stratifying patients for trials in inflammatory bowel disease . Trends Immunol vol. 34 , ( 11 ) 564 - 571 .

Sarra M, Cupi ML, Bernardini R, Ronchetti G, Monteleone I, Ranalli M, Franzè E, Rizzo A et al. ( 2013 ) . IL-25 prevents and cures fulminant hepatitis in mice through a myeloid-derived suppressor cell-dependent mechanism . Hepatology vol. 58 , ( 4 ) 1436 - 1450 .

McCarthy NE, Bashir Z, Vossenkämper A, Hedin CR, Giles EM, Bhattacharjee S, Brown SG, Sanders TJ et al. ( 2013 ) . Proinflammatory Vδ2+ T cells populate the human intestinal mucosa and enhance IFN-γ production by colonic αβ T cells . J Immunol vol. 191 , ( 5 ) 2752 - 2763 .

Vossenkämper A, Blair PA, Safinia N, Fraser LD, Das L, Sanders TJ, Stagg AJ, Sanderson JD et al. ( 2013 ) . A role for gut-associated lymphoid tissue in shaping the human B cell repertoire . J Exp Med vol. 210 , ( 9 ) 1665 - 1674 .

Biancheri P, Pender SL, Ammoscato F, Giuffrida P, Sampietro G, Ardizzone S, Ghanbari A, Curciarello R et al. ( 2013 ) . The role of interleukin 17 in Crohn's disease-associated intestinal fibrosis . Fibrogenesis Tissue Repair vol. 6 , ( 1 )

Franzè E, Caruso R, Stolfi C, Sarra M, Cupi ML, Ascolani M, Sedda S, Antenucci C et al. ( 2013 ) . High expression of the "A Disintegrin And Metalloprotease" 19 (ADAM19), a sheddase for TNF-α in the mucosa of patients with inflammatory bowel diseases . Inflamm Bowel Dis vol. 19 , ( 3 ) 501 - 511 .

Biancheri P, Di Sabatino A, Gough P, Votta B, Foley K, Vossenkaemper A, Bertin J, Corazza GR et al. ( 2013 ) . OC.07.2 SELECTIVE INHIBITION OF RIP2 KINASE ACTIVITY REDUCES PRO-INFLAMMATORY CYTOKINE PRODUCTION IN INFLAMMATORY BOWEL DISEASE MUCOSA . Digestive and Liver Disease vol. 45 ,

Biancheri P, Di Sabatino A, Rovedatti L, Giuffrida P, Calarota SA, Vetrano S, Vidali F, Pasini A et al. ( 2013 ) . Effect of tumor necrosis factor-α blockade on mucosal addressin cell-adhesion molecule-1 in Crohn's disease . Inflamm Bowel Dis vol. 19 , ( 2 ) 259 - 264 .

Kok K, Curciarello R, Biancheri P, Langmead L, MacDonald T ( 2013 ) . P019 The role of human neutrophil elastase and its inhibitor elafin in ulcerative colitis . Journal of Crohn's and Colitis vol. 7 , ( Supplement_1 ) s18 - s18 .

Biancheri P, Nijhuis A, Di Sabatino A, Lai C, Ghosh A, MacDonald TT, Corazza GR, Lindsay J et al. ( 2013 ) . P057 Micro-RNA expression profiling identifies miR-29b as a relevant pro-fibrogenic factor in Crohn's disease intestinal strictures . Journal of Crohn's and Colitis vol. 7 , ( Supplement_1 ) s32 - s32 .

McCarthy N, Hedin C, Bashir Z, Vossenkämper A, Giles E, Sanders T, Whelan K, MacDonald T et al. ( 2013 ) . P066 Human intestinal Vδ2+ T-cells promote mucosal inflammation in Crohn's disease and are selectively ablated by azathioprine therapy . Journal of Crohn's and Colitis vol. 7 , ( Supplement_1 ) s35 - s36 .

Di Sabatino A, Brunetti L, Biancheri P, Ciccocioppo R, Guerci M, Casella C, Vidali F, MacDonald TT et al. ( 2013 ) . Mucosal changes induced by ischemia-reperfusion injury in a jejunal loop transplanted in oropharynx . INTERNAL AND EMERGENCY MEDICINE vol. 8 , ( 4 ) 317 - 325 .

Biancheri P, Di Sabatino A, Corazza GR, MacDonald TT ( 2013 ) . Proteases and the gut barrier . CELL AND TISSUE RESEARCH vol. 351 , ( 2 ) 269 - 280 .

Biancheri P, Di Sabatino A, Fornasa G, Giuffrida P, Rovedatti L, Pasini A, Ammoscato F, MacDonald TT et al. ( 2013 ) . Thymic Stromal Lymphopoietin Is Primarily Reduced in Untreated Celiac Disease Mucosa . GASTROENTEROLOGY . vol. 144 , S242 - S242 .

MacDonald TT, Biancheri P, Sarra M, Monteleone G ( 2012 ) . What's the next best cytokine target in IBD? . Inflamm Bowel Dis vol. 18 , ( 11 ) 2180 - 2189 .

Powell N, Walker AW, Stolarczyk E, Canavan JB, Gökmen MR, Marks E, Jackson I, Hashim A et al. ( 2012 ) . The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor+ innate lymphoid cells . Immunity vol. 37 , ( 4 ) 674 - 684 .

Biancheri P, Ammoscato F, Di Sabatino A, Joe-Njoku I, Rovedatti L, Corazza GR, MacDonald TT ( 2012 ) . Tu1895 Does Interleukin (IL)-13 Have a Role in Sustaining the Mucosal PRO-Inflammatory Immune Response in Ulcerative Colitis and in Promoting Intestinal Fibrogenesis in Crohn's Disease? . Gastroenterology vol. 142 , ( 5 ) s - 872 .

Biancheri P, Nijhuis A, Lai C, Ghosh A, Feakins R, Chan C, Di Sabatino A, Corazza GR et al. ( 2012 ) . Tu1915 Differential MicroRNA Expression Profiles in Crohn's Disease Strictured Versus Non-Strictured Intestine . Gastroenterology vol. 142 , ( 5 ) s - 877 .

Gough P, Votta B, Casillas L, Haile P, Lipshutz D, Desai B, Swift B, Capriotti CA et al. ( 2012 ) . Tu1921 Selective Inhibitors of RIP2 Kinase Activity Reduce PRO-Inflammatory Cytokine Production in IBD Mucosal Biopsy Cultures and Inflammation in Murine TNBS-Induced Colitis . Gastroenterology vol. 142 , ( 5 ) s - 878 .

Canavan JB, Afzali B, Scotta C, Fazekasova H, Edozie FC, Macdonald TT, Hernandez-Fuentes MP, Lombardi G et al. ( 2012 ) . A rapid diagnostic test for human regulatory T-cell function to enable regulatory T-cell therapy . BLOOD vol. 119 , ( 8 ) E57 - E66 .

MacDonald TT, Harper JI, Kelsell DP ( 2012 ) . Inflammatory Bowel Disease and <i>ADAM17</i> Deletion REPLY . NEW ENGLAND JOURNAL OF MEDICINE vol. 366 , ( 2 ) 190 - 190 .

Stolfi C, Pallone F, Macdonald TT, Monteleone G ( 2012 ) . Interleukin-21 in cancer immunotherapy Friend or foe? . ONCOIMMUNOLOGY vol. 1 , ( 3 ) 351 - 354 .

Di Sabatino A, Biancheri P, Rovedatti L, MacDonald TT, Corazza GR ( 2012 ) . New pathogenic paradigms in inflammatory bowel disease . INFLAMMATORY BOWEL DISEASES vol. 18 , ( 2 ) 368 - 371 .

Di Sabatino A, Biancheri P, Rovedatti L, MacDonald TT, Corazza GR ( 2012 ) . Recent advances in understanding ulcerative colitis . INTERNAL AND EMERGENCY MEDICINE vol. 7 , ( 2 ) 103 - 111 .

MacDonald TT, Vossenkaemper A, Fantini M, Monteleone G ( 2012 ) . Reprogramming the immune system in IBD . Dig Dis vol. 30 , ( 4 ) 392 - 395 .

Powell N, Stolarczyk E, Canavan JB, Marks E, MacDonald TT, Lord G ( 2012 ) . T-bet Regulates Cytokine Expression by Intestinal Innate Lymphoid Cells . GASTROENTEROLOGY . vol. 142 , S175 - S176 .

Monteleone I, MacDonald TT, Pallone F, Monteleone G ( 2012 ) . The aryl hydrocarbon receptor in inflammatory bowel disease: linking the environment to disease pathogenesis . CURRENT OPINION IN GASTROENTEROLOGY vol. 28 , ( 4 ) 310 - 313 .

Monteleone I, Federici M, Sarra M, Franze E, Casagrande V, Zorzi F, Cavalera M, Rizzo A et al. ( 2012 ) . Tissue Inhibitor of Metalloproteinase-3 Regulates Inflammation in Human and Mouse Intestine . GASTROENTEROLOGY vol. 143 , ( 5 ) 1277 - + .

Stolfi C, Rizzo A, Franze E, Rotondi A, Fantini MC, Sarra M, Caruso R, Monteleone I et al. ( 2011 ) . Involvement of interleukin-21 in the regulation of colitis-associated colon cancer . J EXP MED vol. 208 , ( 11 ) 2279 - 2290 .

Blaydon DC, Biancheri P, Di W-L, Plagnol V, Cabral RM, Brooke MA, van Heel DA, Ruschendorf F et al. ( 2011 ) . Inflammatory skin and bowel disease linked to ADAM17 deletion . N Engl J Med vol. 365 , ( 16 ) 1502 - 1508 .

Vossenkamper A, Fikree A, Fairclough PD, Aziz Q, MacDonald TT ( 2011 ) . Colonic Lymphoid Nodular Hyperplasia in an Adolescent . Journal of Pediatric Gastroenterology and Nutrition vol. 53 , ( 6 ) 684 - 686 .

Di Sabatino A, Battista N, Biancheri P, Rapino C, Rovedatti L, Astarita G, Vanoli A, Dainese E et al. ( 2011 ) . The endogenous cannabinoid system in the gut of patients with inflammatory bowel disease . MUCOSAL IMMUNOL vol. 4 , ( 5 ) 574 - 583 .

MacDonald TT, Bell I, Monteleone G ( 2011 ) . The opposing roles of IL-21 and TGFβ1 in chronic inflammatory bowel disease . Biochem Soc Trans vol. 39 , ( 4 ) 1061 - 1066 .

Monteleone I, Rizzo A, Sarra M, Sica G, Sileri P, Biancone L, MacDonald TT, Pallone F et al. ( 2011 ) . Aryl Hydrocarbon Receptor-Induced Signals Up-regulate IL-22 Production and Inhibit Inflammation in the Gastrointestinal Tract . GASTROENTEROLOGY vol. 141 , ( 1 ) 237 - U324 .

Di Sabatino A, Battista N, Biancheri P, Rapino C, Rovedatti L, Astarita G, Vanoli A, Dainese E et al. ( 2011 ) . Correction: Corrigendum: The endogenous cannabinoid system in the gut of patients with inflammatory bowel disease . Mucosal Immunology vol. 4 , ( 4 )

Macdonald TT ( 2011 ) . New cytokine targets in inflammatory bowel disease . Gastroenterol Hepatol (N Y) vol. 7 , ( 7 ) 474 - 476 .

Vossenkämper A, Macdonald TT, Marchès O ( 2011 ) . Always one step ahead: How pathogenic bacteria use the type III secretion system to manipulate the intestinal mucosal immune system . J Inflamm (Lond) vol. 8 ,

Rovedatti L, Di Sabatino A, Knowles CH, Sengupta N, Biancheri P, Corazza GR, MacDonald TT ( 2011 ) . Fibroblast activation protein expression in Crohn's disease strictures . Inflamm Bowel Dis vol. 17 , ( 5 ) 1251 - 1253 .

Sarra M, Caruso R, Cupi ML, Monteleone I, Stolfi C, Campione E, Diluvio L, Mazzotta A et al. ( 2011 ) . IL-21 Promotes Skin Recruitment of CD4(+) Cells and Drives IFN-gamma-Dependent Epidermal Hyperplasia . J IMMUNOL vol. 186 , ( 9 ) 5435 - 5442 .

MacDonald TT, Monteleone I, Fantini MC, Monteleone G ( 2011 ) . Regulation of homeostasis and inflammation in the intestine . Gastroenterology vol. 140 , ( 6 ) 1768 - 1775 .

Fina D, Franze E, Rovedatti L, Corazza GR, Biancone L, Sileri PP, Sica G, MacDonald TT et al. ( 2011 ) . Interleukin-25 production is differently regulated by TNF-alpha and TGF-beta 1 in the human gut . MUCOSAL IMMUNOL vol. 4 , ( 2 ) 239 - 244 .

Di Sabatino A, Rovedatti L, Vetrano S, Vidali F, Biancheri P, Rescigno M, Danese S, MacDonald TT et al. ( 2011 ) . Involvement of CD40-CD40 Ligand in Uncomplicated and Refractory Celiac Disease . AM J GASTROENTEROL vol. 106 , ( 3 ) 519 - 527 .

Di Sabatino A, Calarota SA, Vidali F, MacDonald TT, Corazza GR ( 2011 ) . Role of IL-15 in immune-mediated and infectious diseases . CYTOKINE GROWTH F R vol. 22 , ( 1 ) 19 - 33 .

Monteleone G, Pallone F, MacDonald TT ( 2011 ) . Emerging immunological targets in inflammatory bowel disease . CURRENT OPINION IN PHARMACOLOGY vol. 11 , ( 6 ) 640 - 645 .

Monteleone G, Pallone F, MacDonald TT, Chimenti S, Costanzo A ( 2011 ) . Psoriasis: from pathogenesis to novel therapeutic approaches . CLIN SCI vol. 120 , ( 1-2 ) 1 - 11 .

Rizzo A, Waldner MJ, Stolfi C, Sarra M, Fina D, Becker C, Neurath MF, Macdonald TT et al. ( 2011 ) . Smad7 Expression in T cells Prevents Colitis- Associated Cancer . CANCER RESEARCH vol. 71 , ( 24 ) 7423 - 7432 .

MacDonald TT, Bell I, Monteleone G ( 2010 ) . Cytokine regulation of gut inflammation in IBD . Inflammatory Bowel Disease Monitor vol. 10 , ( 4 ) 111 - 116 .

Monteleone G, Pallone F, MacDonald TT ( 2010 ) . Interleukin-25: A two-edged sword in the control of immune-inflammatory responses . CYTOKINE GROWTH F R vol. 21 , ( 6 ) 471 - 475 .

Macdonald TT ( 2010 ) . Inside the microbial and immune labyrinth: totally gutted . Nat Med vol. 16 , ( 11 ) 1194 - 1195 .

Di Sabatino A, Biancheri P, Piconese S, Rosado MM, Ardizzone S, Rovedatti L, Ubezio C, Massari A et al. ( 2010 ) . Peripheral Regulatory T Cells and Serum Transforming Growth Factor-beta: Relationship with Clinical Response to Infliximab in Crohn's Disease . INFLAMM BOWEL DIS vol. 16 , ( 11 ) 1891 - 1897 .

Powell N, Canavan JB, MacDonald TT, Lord GM ( 2010 ) . Transcriptional regulation of the mucosal immune system mediated by T-bet . Mucosal Immunol vol. 3 , ( 6 ) 567 - 577 .

Docena G, Rovedatti L, Kruidenier L, Fanning A, Leakey NAB, Knowles CH, Lee K, Shanahan F et al. ( 2010 ) . Down-regulation of p38 mitogen-activated protein kinase activation and proinflammatory cytokine production by mitogen-activated protein kinase inhibitors in inflammatory bowel disease . Clin Exp Immunol vol. 162 , ( 1 ) 108 - 115 .

Sarra M, Pallone F, MacDonald TT, Monteleone G ( 2010 ) . IL-23/IL-17 Axis in IBD . INFLAMM BOWEL DIS vol. 16 , ( 10 ) 1808 - 1813 .

Vossenkämper A, Marchès O, Fairclough PD, Warnes G, Stagg AJ, Lindsay JO, Evans PC, Luong LA et al. ( 2010 ) . Inhibition of NF-κB signaling in human dendritic cells by the enteropathogenic Escherichia coli effector protein NleE . J Immunol vol. 185 , ( 7 ) 4118 - 4127 .

Günther U, Bateman AC, Beattie RM, Bauer M, MacDonald TT, Kaskas BA ( 2010 ) . Connective tissue growth factor expression is increased in collagenous colitis and coeliac disease . Histopathology vol. 57 , ( 3 ) 427 - 435 .

Sarra M, Monteleone I, Stolfi C, Fantini MC, Sileri P, Sica G, Tersigni R, Macdonald TT et al. ( 2010 ) . Interferon-gamma-expressing Cells Are a Major Source of Interleukin-21 in Inflammatory Bowel Diseases . INFLAMM BOWEL DIS vol. 16 , ( 8 ) 1332 - 1339 .

MacDonald TT, Bell I ( 2010 ) . Probiotics and the immune response to vaccines . Proc Nutr Soc vol. 69 , ( 3 ) 442 - 446 .

MacDonald TT ( 2010 ) . Cytokine regulation of intestinal epithelial cell proliferation . Expert Rev Clin Immunol vol. 6 , ( 4 ) 531 - 535 .

Epstein J, Sanderson IR, Macdonald TT ( 2010 ) . Curcumin as a therapeutic agent: the evidence from in vitro, animal and human studies . Br J Nutr vol. 103 , ( 11 ) 1545 - 1557 .

MacDonald TT, Monteleone G ( 2010 ) . Adaptive Immunity: Effector and Inhibitory Cytokine Pathways in Gut Inflammation . Inflammatory Bowel Disease , Wiley

Sarra M, Pallone F, Macdonald TT, Monteleone G ( 2010 ) . Targeting Interleukin-21 in Immune-Mediated Pathologies . CURR DRUG TARGETS vol. 11 , ( 5 ) 645 - 649 .

Epstein J, Docena G, MacDonald TT, Sanderson IR ( 2010 ) . Curcumin suppresses p38 mitogen-activated protein kinase activation, reduces IL-1beta and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children and adults with inflammatory bowel disease . Br J Nutr vol. 103 , ( 6 ) 824 - 832 .

Monteleone I, Sarra M, Blanco GDV, Paoluzi OA, Franze E, Fina D, Fabrizi A, MacDonald TT et al. ( 2010 ) . Characterization of IL-17A-Producing Cells in Celiac Disease Mucosa . J IMMUNOL vol. 184 , ( 4 ) 2211 - 2218 .

Sengupta N, MacFie TS, MacDonald TT, Pennington D, Silver AR ( 2010 ) . Cancer immunoediting and "spontaneous" tumor regression . Pathol Res Pract vol. 206 , ( 1 ) 1 - 8 .

Stolfi C, Sarra M, Caruso R, Fantini MC, Fina D, Pellegrini R, Palmieri G, MacDonald TT et al. ( 2010 ) . Inhibition of Colon Carcinogenesis by 2-Methoxy-5-Amino-N-Hydroxybenzamide, a Novel Derivative of Mesalamine . GASTROENTEROLOGY vol. 138 , ( 1 ) 221 - 230 .

( 2010 ) . News & Highlights . Mucosal Immunology vol. 3 , ( 1 ) 2 - 3 .

Rovedatti L, Kudo T, Biancheri P, Sarra M, Knowles CH, Rampton DS, Corazza GR, Monteleone G et al. ( 2009 ) . Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease . Gut vol. 58 , ( 12 ) 1629 - 1636 .

MacDonald TT, Di Sabatino A ( 2009 ) . The immunologic basis for gastrointestinal food allergy . Curr Opin Gastroenterol vol. 25 , ( 6 ) 521 - 526 .

Gordon JN, Prothero JD, Thornton CA, Pickard KM, Di Sabatino A, Goggin PM, Pender SL, MacDonald TT ( 2009 ) . CC-10004 but not thalidomide or lenalidomide inhibits lamina propria mononuclear cell TNF-alpha and MMP-3 production in patients with inflammatory bowel disease . J CROHNS COLITIS vol. 3 , ( 3 ) 175 - 182 .

Caruso R, Botti E, Sarra M, Esposito M, Stolfi C, Diluvio L, Giustizieri ML, Pacciani V et al. ( 2009 ) . Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis . NAT MED vol. 15 , ( 9 ) 1013 - 1015 .

Di Sabatino A, Saarialho-Kere U, Buckley MG, Gordon JN, Biancheri P, Rovedatti L, Corazza GR, Macdonald TT et al. ( 2009 ) . Stromelysin-1 and macrophage metalloelastase expression in the intestinal mucosa of Crohn's disease patients treated with infliximab . Eur J Gastroenterol Hepatol vol. 21 , ( 9 ) 1049 - 1055 .

Di Sabatino A, Rovedatti L, Kaur R, Spencer JP, Brown JT, Morisset VD, Biancheri P, Leakey NAB et al. ( 2009 ) . Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits T cell cytokine production and T-box transcription factor T-bet in inflammatory bowel disease . J Immunol vol. 183 , ( 5 ) 3454 - 3462 .

MacDonald TT, Vossenkamper A, Di Sabatino A ( 2009 ) . Antigen presenting cells and T cell interactions in the gastrointestinal tract . Mol Nutr Food Res vol. 53 , ( 8 ) 947 - 951 .

Monteleone G, Pallone F, Macdonald TT ( 2009 ) . Interleukin-21 as a new therapeutic target for immune-mediated diseases . TRENDS PHARMACOL SCI vol. 30 , ( 8 ) 441 - 447 .

Monteleone G, MacDonald TT ( 2009 ) . Manipulation of cytokines in the management of patients with inflammatory bowel disease . Annals of Medicine vol. 32 , ( 8 ) 552 - 560 .

Macdonald TT, Carter PB ( 2009 ) . A Functional Relationship Between Delayed Hypersensitivtiy and Antibacterial Immunity . Immunological Investigations vol. 10 , ( 7 ) 591 - 599 .

Caruso R, Sarra M, Stolfi C, Rio A, Fina D, Fantini MC, Pallone F, MacDonald TT et al. ( 2009 ) . Interleukin-25 Inhibits Interleukin-12 Production and Th1 Cell-Driven Inflammation in the Gut . GASTROENTEROLOGY vol. 136 , ( 7 ) 2270 - 2279 .

Di Sabatino A, Jackson CL, Pickard KM, Buckley M, Rovedatti L, Leakey NAB, Picariello L, Cazzola P et al. ( 2009 ) . Transforming growth factor beta signalling and matrix metalloproteinases in the mucosa overlying Crohn's disease strictures . Gut vol. 58 , ( 6 ) 777 - 789 .

Di Sabatino A, Rovedatti L, Rosado MM, Carsetti R, Corazza GR, MacDonald TT ( 2009 ) . Increased expression of mucosal addressin cell adhesion molecule 1 in the duodenum of patients with active celiac disease is associated with depletion of integrin alpha4beta7-positive T cells in blood . Hum Pathol vol. 40 , ( 5 ) 699 - 704 .

Caruso R, Stolfi C, Sarra M, Rizzo A, Fantini MC, Pallone F, MacDonald TT, Monteleone G ( 2009 ) . Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3 . Blood vol. 113 , ( 15 ) 3512 - 3519 .

Cooper ES, Whyte-Alleng CAM, Finzi-Smith JS, MacDonald TT ( 2009 ) . Intestinal nematode infections in children: the pathophysiological price paid . Parasitology vol. 104 , ( S1 ) s91 - s103 .

Monteleone G, Pallone F, Macdonald TT ( 2009 ) . Interleukin-21 (IL-21)-mediated pathways in T cell-mediated disease . CYTOKINE GROWTH F R vol. 20 , ( 2 ) 185 - 191 .

Fantini MC, Rizzo A, Fina D, Caruso R, Sarra M, Stolfi C, Becker C, Macdonald TT et al. ( 2009 ) . Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression . Gastroenterology vol. 136 , ( 4 ) 1308 - e3 .

MacDonald TT, Spencer J ( 2009 ) . The Role of Activated T Cells in Transformed Intestinal Mucosa . Digestion vol. 46 , ( Suppl 2 ) 290 - 296 .

Chuang S-L, Hayes PJ, Ogundipe E, Haddad M, MacDonald TT, Fell JM ( 2009 ) . Cow's milk protein-specific T-helper type I/II cytokine responses in infants with necrotizing enterocolitis . Pediatr Allergy Immunol vol. 20 , ( 1 ) 45 - 52 .

Ferguson A, Carr KE, MacDonald TT, Watt C ( 2009 ) . Hypersensitivity Reactions in the Small Intestine . Digestion vol. 18 , ( 1-2 ) 56 - 63 .

Hemrajani C, Marches O, Wiles S, Girard F, Dennis A, Dziva F, Best A, Phillips AD et al. ( 2008 ) . Role of NleH, a type III secreted effector from attaching and effacing pathogens, in colonization of the bovine, ovine, and murine gut . Infect Immun vol. 76 , ( 11 ) 4804 - 4813 .

Monteleone G, Boirivant M, Pallone F, MacDonald TT ( 2008 ) . TGF-beta1 and Smad7 in the regulation of IBD . Mucosal Immunol . vol. 1 Suppl 1 , S50 - S53 .

Dennis A, Kudo T, Kruidenier L, Girard F, Crepin VF, MacDonald TT, Frankel G, Wiles S ( 2008 ) . The p50 subunit of NF-kappaB is critical for in vivo clearance of the noninvasive enteric pathogen Citrobacter rodentium . Infect Immun vol. 76 , ( 11 ) 4978 - 4988 .

Fina D, Pallone F, Macdonald TT, Monteleone G ( 2008 ) . Role of neutrophil recruitment in the amelioration of experimental colitis by genetic ablation of interleukin-21 - Reply . GASTROENTEROLOGY vol. 135 , ( 4 ) 1426 - 1427 .

MacDonald TT ( 2008 ) . Round table discussion: Host immune system and commensal flora as the stimulus to the gut . International Journal of Probiotics and Prebiotics . vol. 3 , 147 - 148 .

Di Sabatino A, Miceli E, Dhaliwal W, Biancheri P, Salerno R, Cantoro L, Vanoli A, De Vincenzi M et al. ( 2008 ) . Distribution, proliferation, and function of Paneth cells in uncomplicated and complicated adult celiac disease . Am J Clin Pathol vol. 130 , ( 1 ) 34 - 42 .

Fina D, Sarra M, Caruso R, Del Vecchio Blanco G, Pallone F, MacDonald TT, Monteleone G ( 2008 ) . Interleukin 21 contributes to the mucosal T helper cell type 1 response in coeliac disease . Gut vol. 57 , ( 7 ) 887 - 892 .

MacDonald TT ( 2008 ) . The gut is still the biggest lymphoid organ in the body . MUCOSAL IMMUNOL vol. 1 , ( 4 ) 246 - 247 .

MacDonald TT ( 2008 ) . Breakdown of tolerance to the intestinal bacterial flora in inflammatory bowel disease (IBD) . Clinical & Experimental Immunology vol. 102 , ( 3 ) 445 - 447 .

DOAN A, MacDONALD TT, SPENCER J ( 2008 ) . Ontogeny and induction of adhesion molecule expression in human fetal intestine . Clinical & Experimental Immunology vol. 91 , ( 3 ) 532 - 537 .

MacDonald TT, Hutchings P, Choy M-Y, Murch S, Cooke A ( 2008 ) . Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine . Clinical & Experimental Immunology vol. 81 , ( 2 ) 301 - 305 .

Monteleone G, Pallone F, MacDonald TT ( 2008 ) . Interleukin-21: a critical regulator of the balance between effector and regulatory T-cell responses . Trends Immunol vol. 29 , ( 6 ) 290 - 294 .

Ferguson A, MacDonald TT ( 2008 ) . Effects of Local Delayed Hypersensitivity on the Small Intestine . Novartis Foundation Symposia ( 46 ) 305 - 327 .

Di Sabatino A, Pickard KM, Rampton D, Kruidenier L, Rovedatti L, Leakey NAB, Corazza GR, Monteleone G et al. ( 2008 ) . Blockade of transforming growth factor beta upregulates T-box transcription factor T-bet, and increases T helper cell type 1 cytokine and matrix metalloproteinase-3 production in the human gut mucosa . Gut vol. 57 , ( 5 ) 605 - 612 .

MacDonald TT, Ferguson A ( 2008 ) . HYPERSENSITIVITY REACTIONS IN THE SMALL INTESTINE . Cell Proliferation vol. 10 , ( 4 ) 301 - 312 .

Caprioli F, Sarra M, Caruso R, Stolfi C, Fina D, Sica G, MacDonald TT, Pallone F et al. ( 2008 ) . Autocrine regulation of interleukin-21 production in human peripheral blood and intestinal T lymphocytes . GASTROENTEROLOGY vol. 134 , ( 4 ) A2 - A2 .

Di Sabatino A, Rovedatti L, Biancheri P, Rosado M, Cantoro L, Carsetti R, Corazza GR, MacDonald TT ( 2008 ) . Mucosal addressin cell adhesion molecule-1 in celiac disease . GASTROENTEROLOGY vol. 134 , ( 4 ) A519 - A519 .

Fina D, Sarra M, Fantini MC, Rizzo A, Caruso R, Caprioli F, Stolfi C, Cardolini I et al. ( 2008 ) . Regulation of gut inflammation and th17 cell response by interleukin-21 . Gastroenterology vol. 134 , ( 4 ) 1038 - 1048 .

Fantini MC, Rizzo A, Fina D, Sarra M, Caruso R, Becker C, Pallone F, Macdonald TT et al. ( 2008 ) . T cell-specific Smad7 over-expression reduces regulatory T cell-mediated control of colitis . GASTROENTEROLOGY vol. 134 , ( 4 ) A72 - A73 .

Fantini MC, Monteleone G, MacDonald TT ( 2008 ) . IL-21 comes of age as a regulator of effector T cells in the gut . Mucosal Immunol vol. 1 , ( 2 ) 110 - 115 .

Caprioli F, Sarra M, Caruso R, Stolfi C, Fina D, Sica G, MacDonald TT, Pallone F et al. ( 2008 ) . Autocrine regulation of IL-21 production in human T lymphocytes . J Immunol vol. 180 , ( 3 ) 1800 - 1807 .

Caruso R, Fina D, Paoluzi OA, Del Vecchio Blanco G, Stolfi C, Rizzo A, Caprioli F, Sarra M et al. ( 2008 ) . IL-23-mediated regulation of IL-17 production in Helicobacter pylori-infected gastric mucosa . Eur J Immunol vol. 38 , ( 2 ) 470 - 478 .

Gordon JN, Pickard KM, Di Sabatino A, Prothero JD, Pender SLF, Goggin PM, MacDonald TT ( 2008 ) . Matrix metalloproteinase-3 production by gut IgG plasma cells in chronic inflammatory bowel disease . Inflamm Bowel Dis . vol. 14 , 195 - 203 .

MacDonald TT, Spencer J ( 2008 ) . Ontogeny of the gut‐associated lymphoid system in man . Acta paediatrica (Oslo, Norway : 1992). Supplement vol. 83 , ( 395 ) 3 - 5 .

Gordon JN, Pickard KM, Di Sabatino A, Prothero JD, Pender SL, Goggin PM, MacDonald T ( 2008 ) . Matrix metalloproteinase-3 production by gut IgG plasma cells in chronic inflammatory bowel disease . Inflamm Bowel Dis vol. 14 , ( 2 ) 195 - 203 .

Blumberg RS, MacDonald TT ( 2008 ) . Mucosal immunology: a frontier no longer . MUCOSAL IMMUNOL vol. 1 , ( 1 ) 3 - 3 .

Sengupta N, MacDonald TT ( 2007 ) . The role of matrix metalloproteinases in stromal/epithelial interactions in the gut . Physiology (Bethesda) vol. 22 , 401 - 409 .

Fantini MC, Rizzo A, Fina D, Caruso R, Becker C, Neurath MF, Macdonald TT, Pallone F et al. ( 2007 ) . IL-21 regulates experimental colitis by modulating the balance between Treg and Th17 cells . Eur J Immunol vol. 37 , ( 11 ) 3155 - 3163 .

Fantini MC, Monteleone G, Macdonald TT ( 2007 ) . New players in the cytokine orchestra of inflammatory bowel disease . Inflamm Bowel Dis vol. 13 , ( 11 ) 1419 - 1423 .

DILLON SB, MACDONALD TT ( 2007 ) . Limit dilution analysis of mast cell precursor frequency in the gut epithelium of normal and Trichinella spiralis infected mice . Parasite Immunology vol. 8 , ( 5 ) 503 - 511 .

Macdonald TT, Domizio P ( 2007 ) . Autistic enterocolitis: is it a histopathological entity? . Histopathology vol. 51 , ( 4 ) 552 - 553 .

Di Sabatino A, Pickard KM, Gordon JN, Salvati V, Mazzarella G, Beattie RM, Vossenkaemper A, Rovedatti L et al. ( 2007 ) . Evidence for the role of interferon-alfa production by dendritic cells in the Th1 response in celiac disease . Gastroenterology vol. 133 , ( 4 ) 1175 - 1187 .

Di Sabatino A, Pender SLF, Jackson CL, Prothero JD, Gordon JN, Picariello L, Rovedatti L, Docena G et al. ( 2007 ) . Functional modulation of Crohn's disease myofibroblasts by anti-tumor necrosis factor antibodies . Gastroenterology vol. 133 , ( 1 ) 137 - 149 .

Caruso R, Fina D, Peluso I, Fantini MC, Tosti C, Del Vecchio Blanco G, Paoluzi OA, Caprioli F et al. ( 2007 ) . IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis . J Immunol vol. 178 , ( 9 ) 5957 - 5965 .

BEATTIE RM, SCHIFFRIN EJ, DONNET‐HUGHES A, HUGGETT AC, DOMIZIO P, MACDONALD TT, WALKER‐SMITH JA ( 2007 ) . Polgmeric nutrition as the primary therapy in children with small bowel Crohn's disease . Alimentary Pharmacology & Therapeutics vol. 8 , ( 6 ) 609 - 615 .

BREESE EJ, MICHIE CA, NICHOLLS SW, WILLIAMS CB, DOMIZIO† P, WALKER‐SMITH JA, MACDONALD TT ( 2007 ) . The effect of treatment on lymphokine‐secreting cells in the intestinal mucosa of children with Crohn's disease . Alimentary Pharmacology & Therapeutics vol. 9 , ( 5 ) 547 - 552 .

Lottaz D, Buri C, Monteleone G, Rösmann S, Macdonald TT, Sanderson IR, Sterchi EE ( 2007 ) . Compartmentalised expression of meprin in small intestinal mucosa: enhanced expression in lamina propria in coeliac disease . Biol Chem vol. 388 , ( 3 ) 337 - 341 .

MacDonald TT, Domizio P ( 2007 ) . Autistic enterocolitis; is it a histopathological entity? . Histopathology vol. 50 , ( 3 ) 371 - 379 .

Peluso I, Fantini MC, Fina D, Caruso R, Boirivant M, MacDonald TT, Pallone F, Monteleone G ( 2007 ) . IL-21 counteracts the regulatory T cell-mediated suppression of human CD4+ T lymphocytes . J Immunol vol. 178 , ( 2 ) 732 - 739 .

Caruso R, Fina D, Peluso I, Stolfi C, Fantini MC, Gioia V, Caprioli F, Del Vecchio Blanco G et al. ( 2007 ) . A functional role for interleukin-21 in promoting the synthesis of the T-cell chemoattractant, MIP-3alpha, by gut epithelial cells . Gastroenterology vol. 132 , ( 1 ) 166 - 175 .

Monteleone G, Caruso R, Fina D, Peluso I, Gioia V, Stolfi C, Fantini MC, Caprioli F et al. ( 2006 ) . Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21 . Gut vol. 55 , ( 12 ) 1774 - 1780 .

Boirivant M, Pallone F, Di Giacinto C, Fina D, Monteleone I, Marinaro M, Caruso R, Colantoni A et al. ( 2006 ) . Inhibition of Smad7 with a specific antisense oligonucleotide facilitates TGF-beta1-mediated suppression of colitis . Gastroenterology vol. 131 , ( 6 ) 1786 - 1798 .

Wiles S, Pickard KM, Peng K, MacDonald TT, Frankel G ( 2006 ) . In vivo bioluminescence imaging of the murine pathogen Citrobacter rodentium . Infect Immun vol. 74 , ( 9 ) 5391 - 5396 .

Pender SLF, Li CKF, Di Sabatino A, MacDonald TT, Buckley MG ( 2006 ) . Role of macrophage metalloelastase in gut inflammation . Ann N Y Acad Sci . vol. 1072 , 386 - 388 .

Caruso R, Pallone F, Fina D, Gioia V, Peluso I, Caprioli F, Stolfi C, Perfetti A et al. ( 2006 ) . Protease-activated receptor-2 activation in gastric cancer cells promotes epidermal growth factor receptor trans-activation and proliferation . Am J Pathol vol. 169 , ( 1 ) 268 - 278 .

Chuang SL, Hayes P, Falcorner J, Haddad M, Macdonald TT, Fell JM ( 2006 ) . THE NATURAL HISTORY OF COW'S MILK PROTEIN SENSITISATION IN INFANTILE ALLERGIC COLITIS CONSTIPATION‐ AN ASSOCIATION WITH MULTIPLE FOOD ALLERGY? . Journal of Pediatric Gastroenterology and Nutrition vol. 42 , ( 5 ) e42 - e42 .

MacDonald TT, Di Sabatino A ( 2006 ) . The exposure of infants to Lactobacillus rhamnosus GG in Finland . J Pediatr Gastroenterol Nutr vol. 42 , ( 5 ) 476 - 478 .

MacDonald TT ( 2006 ) . The significance of ileocolonic lymphoid nodular hyperplasia in children with autistic spectrum disorder . Eur J Gastroenterol Hepatol vol. 18 , ( 5 ) 569 - 571 .

MACDONALD TT ( 2006 ) . Evidence for cell‐mediated hypersensitivity as an important pathogenetic mechanism in food intolerance . Clinical & Experimental Allergy vol. 25 , ( s1 ) 10 - 13 .

MACDONALD TT ( 2006 ) . The role of activated T lymphocytes in gastrointestinal disease . Clinical & Experimental Allergy vol. 20 , ( 3 ) 247 - 252 .

Fina D, Peluso I, Caruso R, Valentina G, Stolfi C, MacDonald TT, Pallone F, Monteleone G ( 2006 ) . Regulation of matrix metalloproteinases synthesis by interleukin-21 in human intestinal fibroblasts . INFLAMMATORY BOWEL DISEASES . vol. 12 , S24 - S24 .

PENDER SLF, MACDONALD TT ( 1998 ) . Regulation of Matrix Metalloproteinase Production in Human Fetal Intestinal Mesenchymal Cells by Cytokines and the Bacterial Superantigen Staphylococcus aureus Enterotoxin B . Annals of the New York Academy of Sciences . vol. 859 , 188 - 191 .

BAJAJ‐ELLIOTT M, PENDER SLF, POULSOM R, MACDONALD TT ( 1998 ) . Upregulation of Keratinocyte Growth Factor during T‐Cell Immunity in the Gut Mucosa . Annals of the New York Academy of Sciences . vol. 859 , 184 - 187 .

PENDER SLF, McKENZIE C, SHAIDA A, MacDONALD TT ( 1999 ) . Regulation of Matrix Metalloproteinases in Human Intestinal Mucosa . Annals of the New York Academy of Sciences . vol. 878 , 581 - 582 .

MacDonald TT ( 2006 ) . Decoy receptor springs to life and eases fibrosis . Nat Med vol. 12 , ( 1 ) 13 - 14 .

( 2006 ) . Errata . Journal of Parenteral and Enteral Nutrition vol. 30 , ( 1 ) vii - vii .

Kruidenier L, MacDonald TT, Collins JE, Pender SLF, Sanderson IR ( 2006 ) . Myofibroblast matrix metalloproteinases activate the neutrophil chemoattractant CXCL7 from intestinal epithelial cells . Gastroenterology vol. 130 , ( 1 ) 127 - 136 .

MacDonald TT, Monteleone G ( 2006 ) . Overview of role of the immune system in the pathogenesis of inflammatory bowel disease . Adv Exp Med Biol vol. 579 , 98 - 107 .

Viney JL, Macdonald TT ( 2005 ) . Selective death of T cell receptor γ/δ+ intraepithelial lymphocytes by apoptosis . European Journal of Immunology vol. 20 , ( 12 ) 2809 - 2812 .

Lionetti P, Spencer J, Breese EJ, Murch SH, Taylor J, Macdonald TT ( 2005 ) . Activation of mucosal Vβ3+ T cells and tissue damage in human small intestine by the bacterial superantigen, Staphylococcus aureus enterotoxin B . European Journal of Immunology vol. 23 , ( 3 ) 664 - 668 .

Macdonald TT ( 2005 ) . Immunosuppression caused by antigen feeding. I. Evidence for the activation of a feedback suppressor pathway in the spleens of antigen‐fed mice . European Journal of Immunology vol. 12 , ( 9 ) 767 - 773 .

Doǧan A, MacDonald TT, Spencer J ( 2005 ) . Cyclosporin A enhances T cell‐mediated induction of E‐selectin . European Journal of Immunology vol. 23 , ( 11 ) 2922 - 2926 .

Spencer J, Isaacson PG, Diss TC, Macdonald TT ( 2005 ) . Expression of disulfide‐linked and non‐disulfide‐linked forms of the T cell receptor γ/δ heterodimer in human intestinal intraepithelial lymphocytes . European Journal of Immunology vol. 19 , ( 7 ) 1335 - 1338 .

Dogan A, Dunn‐Walters DK, MacDonald TT, Spencer J ( 2005 ) . Demonstration of local clonality of mucosal T cells in human colon using DNA obtained by microdissection of immunohistochemically stained tissue sections . European Journal of Immunology vol. 26 , ( 6 ) 1240 - 1245 .

Mundy R, MacDonald TT, Dougan G, Frankel G, Wiles S ( 2005 ) . Citrobacter rodentium of mice and man . Cell Microbiol vol. 7 , ( 12 ) 1697 - 1706 .

Latthe M, Terry L, Macdonald TT ( 2005 ) . High frequency of CD8αα homodimer‐bearing T cells in human fetal intestine . European Journal of Immunology vol. 24 , ( 7 ) 1703 - 1705 .

Viney JL, Kilshaw PJ, MacDonald TT ( 2005 ) . Cytotoxic α/β+ and γ/δ+ T cells in murine intestinal epithelium . European Journal of Immunology vol. 20 , ( 7 ) 1623 - 1626 .

Macdonald TT ( 2005 ) . Immunosuppression caused by antigen feeding II. Suppressor T cells mask Peyer's patch B cell priming to orally administered antigen . European Journal of Immunology vol. 13 , ( 2 ) 138 - 142 .

Monteleone G, Del Vecchio Blanco G, Monteleone I, Fina D, Caruso R, Gioia V, Ballerini S, Federici G et al. ( 2005 ) . Post-transcriptional regulation of Smad7 in the gut of patients with inflammatory bowel disease . Gastroenterology vol. 129 , ( 5 ) 1420 - 1429 .

MacDonald TT, Gordon JN ( 2005 ) . Bacterial regulation of intestinal immune responses . Gastroenterol Clin North Am vol. 34 , ( 3 ) 401 - viii .

Prasad S, Mingrino R, Kaukinen K, Hayes KL, Powell RM, MacDonald TT, Collins JE ( 2005 ) . Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells . Lab Invest vol. 85 , ( 9 ) 1139 - 1162 .

Gordon JN, MacDonald TT ( 2005 ) . Osteopontin: a new addition to the constellation of cytokines which drive T helper cell type 1 responses in Crohn's disease . GUT vol. 54 , ( 9 ) 1213 - 1215 .

Pender SL-F, Chance V, Whiting CV, Buckley M, Edwards M, Pettipher R, MacDonald TT ( 2005 ) . Systemic administration of the chemokine macrophage inflammatory protein 1alpha exacerbates inflammatory bowel disease in a mouse model . Gut vol. 54 , ( 8 ) 1114 - 1120 .

Gordon JN, Di Sabatino A, Macdonald TT ( 2005 ) . The pathophysiologic rationale for biological therapies in inflammatory bowel disease . Curr Opin Gastroenterol vol. 21 , ( 4 ) 431 - 437 .

Gunther U, Holloway JA, Knight A, Chance V, Hanley NA, Wilson DI, French R, Spencer J et al. ( 2005 ) . Erratum: Phenotypic characterization of CD3^-7⁺ cells in developing human intestine and an analysis of their ability to differentiate into T cells (Journal of Immunology (2005) 174 (5414-5422)) . Journal of Immunology vol. 174 , ( 12 )

Choy M, Richman PI, Horton MA, Macdonald TT ( 2005 ) . Expression of the VLA family of integrins in human intestine . The Journal of Pathology vol. 160 , ( 1 ) 35 - 40 .

Brittan M, Chance V, Elia G, Poulsom R, Alison MR, MacDonald TT, Wright NA ( 2005 ) . A regenerative role for bone marrow following experimental colitis: contribution to neovasculogenesis and myofibroblasts . Gastroenterology vol. 128 , ( 7 ) 1984 - 1995 .

Gunther U, Holloway JA, Gordon JN, Knight A, Chance V, Hanley NA, Wilson DI, French R et al. ( 2005 ) . Phenotypic characterization of CD3-7+ cells in developing human intestine and an analysis of their ability to differentiate into T cells . J Immunol vol. 174 , ( 9 ) 5414 - 5422 .

Macdonald TT, Monteleone G ( 2005 ) . Immunity, inflammation, and allergy in the gut . Science vol. 307 , ( 5717 ) 1920 - 1925 .

Monteleone G, Monteleone I, Fina D, Vavassori P, Del Vecchio Blanco G, Caruso R, Tersigni R, Alessandroni L et al. ( 2005 ) . Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease . Gastroenterology vol. 128 , ( 3 ) 687 - 694 .

MacDonald TT, Miller RD ( 2005 ) . Chapter 17 Phylogeny of the Gut-Associated Lymphoid Tissue (GALT) . Mucosal Immunology , Elsevier

MacDonald TT, Monteleone G ( 2005 ) . Chapter 22 Human Gut-Associated Lymphoid Tissues . Mucosal Immunology , Elsevier

MacDonald TT, Di Sabatino A, Gordon JN ( 2005 ) . Immunopathogenesis of Crohn's disease . JPEN J Parenter Enteral Nutr vol. 29 , ( 4 Suppl ) S118 - S124 .

MacDonald TT, Pender SL ( 2004 ) . Lamina Propria T Cells . Chemical Immunology and Allergy vol. 71 , 103 - 117 .

Pender SLF, MacDonald TT ( 2004 ) . Matrix metalloproteinases and the gut - new roles for old enzymes . Curr Opin Pharmacol vol. 4 , ( 6 ) 546 - 550 .

Salmela MT, Pender SLF, Karjalainen-Lindsberg M-L, Puolakkainen P, Macdonald TT, Saarialho-Kere U ( 2004 ) . Collagenase-1 (MMP-1), matrilysin-1 (MMP-7), and stromelysin-2 (MMP-10) are expressed by migrating enterocytes during intestinal wound healing . Scand J Gastroenterol vol. 39 , ( 11 ) 1095 - 1104 .

Li CKF, Pender SLF, Pickard KM, Chance V, Holloway JA, Huett A, Gonçalves NS, Mudgett JS et al. ( 2004 ) . Impaired immunity to intestinal bacterial infection in stromelysin-1 (matrix metalloproteinase-3)-deficient mice . J Immunol vol. 173 , ( 8 ) 5171 - 5179 .

Monteleone G, Pallone F, MacDonald TT ( 2004 ) . Smad7 in TGF-beta-mediated negative regulation of gut inflammation . Trends Immunol vol. 25 , ( 10 ) 513 - 517 .

Pender SLF, Croucher PJP, Mascheretti S, Prothero JD, Fisher SA, MacDonald TT, Schreiber S, Ye S ( 2004 ) . Transmission disequilibrium test of stromelysin-1 gene variation in relation to Crohn's disease . J Med Genet vol. 41 , ( 9 )

Monteleone I, Monteleone G, Del Vecchio Blanco G, Vavassori P, Cucchiara S, MacDonald TT, Pallone F ( 2004 ) . Regulation of the T helper cell type 1 transcription factor T-bet in coeliac disease mucosa . Gut vol. 53 , ( 8 ) 1090 - 1095 .

Chuang S, Hayes P, Haddad M, MacDonald TT, Fell JM ( 2004 ) . O0004 INFANTILE ALLERGIC COLITIS (AC): A HETEROGENOUS TH1/TH2 FOOD MEDIATED MUCOSAL INFLAMMATION? . Journal of Pediatric Gastroenterology and Nutrition vol. 39 , ( S1 ) s8 - s8 .

Chuang S, Ogundipe E, Haddad M, MacDonald TT, Fell JM ( 2004 ) . P0147 PP EVIDENCE OF COW’S MILK PROTEIN (CMP) SENSITISATION IN NEONATAL NECROTISING ENTEROCOLITIS (NEC) . Journal of Pediatric Gastroenterology and Nutrition vol. 39 , ( S1 ) s114 - s114 .

Pickard KM, Bremner AR, Gordon JN, MacDonald TT ( 2004 ) . Immune responses . BEST PRACT RES CL GA vol. 18 , ( 2 ) 271 - 285 .

Pickard KM, Bremner AR, Gordon JN, MacDonald TT ( 2004 ) . Microbial-gut interactions in health and disease. Immune responses . Best Pract Res Clin Gastroenterol vol. 18 , ( 2 ) 271 - 285 .

Monteleone G, Del Vecchio Blanco G, Palmieri G, Vavassori P, Monteleone I, Colantoni A, Battista S, Spagnoli LG et al. ( 2004 ) . Induction and regulation of Smad7 in the gastric mucosa of patients with Helicobacter pylori infection . Gastroenterology vol. 126 , ( 3 ) 674 - 682 .

Mimura T, Bateman AC, Lee RL, Johnson PA, MacDonald TT, Pender SLF, McDonald PJ, Talbot IC et al. ( 2004 ) . Up-regulation of collagen and tissue inhibitors of matrix metalloproteinase in colonic diverticular disease - Reply . DIS COLON RECTUM vol. 47 , ( 3 ) 379 - 379 .

Mimura T, Bateman AC, Lee RL, Johnson PA, McDonald PJ, Talbot IC, Kamm MA, MacDonald TT et al. ( 2004 ) . Up-regulation of collagen and tissue inhibitors of matrix metalloproteinase in colonic diverticular disease . Dis Colon Rectum . vol. 47 , 371 - 378 .

Monteleone G, Mann J, Monteleone I, Vavassori P, Bremner R, Fantini M, Del Vecchio Blanco G, Tersigni R et al. ( 2004 ) . A failure of transforming growth factor-beta1 negative regulation maintains sustained NF-kappaB activation in gut inflammation . J Biol Chem vol. 279 , ( 6 ) 3925 - 3932 .

MacDonald TT, Monteleone G ( 2004 ) . The Smad signalling pathway in Crohn's disease and ulcerative colitis . MECHANISMS OF INTESTINAL INFLAMMATION: IMPLICATIONS FOR THERAPEUTIC INTERVENTION IN IBD . Editors: Duchmann, R, Blumberg, RS, Neurath, MF, Scholmerich, J et al. , vol. 133 , 133 - 136 .

Macdonald TT ( 2003 ) . A mouse model of intestinal fibrosis? . Gastroenterology vol. 125 , ( 6 ) 1889 - 1892 .

Gordon JN, MacDonald TT ( 2003 ) . Biological therapy in Crohn's disease . Hosp Med vol. 64 , ( 12 ) 708 - 712 .

MacDONALD TT ( 2003 ) . Accessory cells in the human gastrointestinal tract . Histopathology vol. 29 , ( 1 ) 89 - 92 .

PENNEY L, KILSHAW PJ, MACDONALD TT ( 2003 ) . Increased division of αβ TCR+ and γδ TCR+ intestinal intraepithelial lymphocytes after oral administration of cholera toxin . Immunology vol. 89 , ( 1 ) 54 - 58 .

Fell JME, Walker-Smith JA, Spencer J, MacDonald TT ( 2003 ) . The distribution of dividing T cells throughout the intestinal wall in inflammatory bowel disease (IBD) . Clinical & Experimental Immunology vol. 104 , ( 2 ) 280 - 285 .

Simmons CP, Clare S, Ghaem-Maghami M, Uren TK, Rankin J, Huett A, Goldin R, Lewis DJ et al. ( 2003 ) . Central role for B lymphocytes and CD4+ T cells in immunity to infection by the attaching and effacing pathogen Citrobacter rodentium . Infect Immun vol. 71 , ( 9 ) 5077 - 5086 .

Salvati VM, MacDonald TT, del Vecchio Blanco G, Mazzarella G, Monteleone I, Vavassori P, Auricchio S, Pallone F et al. ( 2003 ) . Enhanced expression of interferon regulatory factor-1 in the mucosa of children with celiac disease . Pediatr Res vol. 54 , ( 3 ) 312 - 318 .

Pender SLF, Braegger C, Gunther U, Monteleone G, Meuli M, Schuppan D, Macdonald TT ( 2003 ) . Matrix metalloproteinases in necrotising enterocolitis . Pediatr Res vol. 54 , ( 2 ) 160 - 164 .

Mazzarella G, MacDonald TT, Salvati VM, Mulligan P, Pasquale L, Stefanile R, Lionetti P, Auricchio S et al. ( 2003 ) . Constitutive activation of the signal transducer and activator of transcription pathway in celiac disease lesions . Am J Pathol vol. 162 , ( 6 ) 1845 - 1855 .

Veitch AM, Higgins LM, Bajaj-Elliot M, Farthing MJG, MacDonald TT ( 2003 ) . Impaired rejection and mucosal injury of small intestinal allografts lacking the interferon-gamma receptor . Int J Exp Pathol vol. 84 , ( 3 ) 107 - 113 .

Gonçalves NS, Hale C, Dougan G, Frankel G, MacDonald TT ( 2003 ) . Binding of intimin from enteropathogenic Escherichia coli to lymphocytes and its functional consequences . Infect Immun vol. 71 , ( 5 ) 2960 - 2965 .

Hauer AC, Riederer M, Griessl A, Rosegger H, MacDonald TT ( 2003 ) . Cytokine production by cord blood mononuclear cells stimulated with cows milk proteins in vitro: interleukin-4 and transforming growth factor beta-secreting cells detected in the CD45RO T cell population in children of atopic mothers . Clin Exp Allergy vol. 33 , ( 5 ) 615 - 623 .

MacDonald TT ( 2003 ) . The mucosal immune system . Parasite Immunol vol. 25 , ( 5 ) 235 - 246 .

MacDonald TT, Frankel G, Dougan G, Goncalves NS, Simmons C ( 2003 ) . Host defences to Citrobacter rodentium . Int J Med Microbiol vol. 293 , ( 1 ) 87 - 93 .

CROFT NM, Pender SL, Salvati M, Monteleone G, Holloway J, Fairclough PD, MacDonald TT ( 2003 ) . Activated STAT4 and a functional role for IL-12 in human Peyer's patches . J. Immunol. vol. 170 , ( 1 ) 300 - 307 .

MacDonald TT, Mazzarella G, Salvati VM, Mulligan P, Pasquale L, Stefanile R, Lionetti P, Troncone R et al. ( 2003 ) . Signal transducer and activator of transcription 1 (STAT1) and suppressor of cytokine signalling 1 (SOCS1) in coeliac disease . Coeliac Disease . Editors: CerfBensussan, N, Brousse, N, CaillatZucman, S, Cellier, C et al. , 89 - 96 .

Salmela MT, MacDonald TT, Black D, Irvine B, Zhuma T, Saarialho-Kere U, Pender SLF ( 2002 ) . Upregulation of matrix metalloproteinases in a model of T cell mediated tissue injury in the gut: analysis by gene array and in situ hybridisation . Gut vol. 51 , ( 4 ) 540 - 547 .

MacDonald TT ( 2002 ) . Suppressor T cells, rebranded as regulatory T cells, emerge from the wilderness bearing surface markers . Gut vol. 51 , ( 3 ) 311 - 312 .

MacDonald TT ( 2002 ) . The Biochemical Basis of Immune Enteropathy . Journal of Pediatric Gastroenterology and Nutrition vol. 34 , ( S1 ) s27 - s30 .

Monteleone G, MacDonald TT, Salvati VM, Mulligan P, Pasquale L, Stefanile R, Lionetti P, Troncone R et al. ( 2002 ) . Activation of signal transducer and activator of transcription 1 in celiac disease . GASTROENTEROLOGY vol. 122 , ( 4 ) A386 - A386 .

Li CKF, Goncalves NS, Bachler M, Chance V, Mudgett J, Dougan G, Frankel G, Pender SLF et al. ( 2002 ) . Critical role of stromelysin-1 (MMP-3) in mucosal T cell responses during Citrobacter rodentium infection in mice . GASTROENTEROLOGY vol. 122 , ( 4 ) A272 - A272 .

Chance V, Goncalves NS, Li CKF, Frankel G, Dougan G, Pender SLF, MacDonald TT ( 2002 ) . Matrix metalloproteinases in Citrobacter rodentium infected TNF receptor (p55) knockout mice . GASTROENTEROLOGY vol. 122 , ( 4 ) A273 - A273 .

Simmons CP, Goncalves NS, Ghaem-Maghami M, Bajaj-Elliott M, Clare S, Neves B, Frankel G, Dougan G et al. ( 2002 ) . Impaired resistance and enhanced pathology during infection with a noninvasive, attaching-effacing enteric bacterial pathogen, Citrobacter rodentium, in mice lacking IL-12 or IFN-gamma . J Immunol vol. 168 , ( 4 ) 1804 - 1812 .

Salvati VM, MacDonald TT, Bajaj-Elliott M, Borrelli M, Staiano A, Auricchio S, Troncone R, Monteleone G ( 2002 ) . Interleukin 18 and associated markers of T helper cell type 1 activity in coeliac disease . Gut vol. 50 , ( 2 ) 186 - 190 .

MacDonald TT ( 2002 ) . The biochemical basis of immune enteropathy . J Pediatr Gastroenterol Nutr . vol. 34 Suppl 1 , S27 - S30 .

Macdonald, Monteleone, Pender ( 2001 ) . Recent Developments in the Immunology of Inflammatory Bowel Disease . Scandinavian Journal of Immunology vol. 51 , ( 1 ) 2 - 9 .

Fell, Paintin, Arnaud‐Battandier, Beattie, Hollis, Kitching, Donnet‐Hughes, Macdonald et al. ( 2001 ) . Mucosal healing and a fall in mucosal pro‐inflammatory cytokine mRNA induced by a specific oral polymeric diet in paediatric Crohn’s disease . Alimentary Pharmacology & Therapeutics vol. 14 , ( 3 ) 281 - 289 .

Gonçalves NS, Ghaem-Maghami M, Monteleone G, Frankel G, Dougan G, Lewis DJ, Simmons CP, MacDonald TT ( 2001 ) . Critical role for tumor necrosis factor alpha in controlling the number of lumenal pathogenic bacteria and immunopathology in infectious colitis . Infect Immun vol. 69 , ( 11 ) 6651 - 6659 .

Shaida A, Kenyon G, Devalia J, Davies RJ, MacDonald TT, Pender SL ( 2001 ) . Matrix metalloproteinases and their inhibitors in the nasal mucosa of patients with perennial allergic rhinitis . J Allergy Clin Immunol vol. 108 , ( 5 ) 791 - 796 .

Monteleone G, Kumberova A, Croft NM, McKenzie C, Steer HW, MacDonald TT ( 2001 ) . Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease . J Clin Invest vol. 108 , ( 4 ) 601 - 609 .

Jones CA, Vance GH, Power LL, Pender SL, Macdonald TT, Warner JO ( 2001 ) . Costimulatory molecules in the developing human gastrointestinal tract: a pathway for fetal allergen priming . J Allergy Clin Immunol vol. 108 , ( 2 ) 235 - 241 .

Monteleone G, Pender SL, Wathen NC, MacDonald TT ( 2001 ) . Interferon-alpha drives T cell-mediated immunopathology in the intestine . Eur J Immunol vol. 31 , ( 8 ) 2247 - 2255 .

Salvati VM, Bajaj-Elliott M, Poulsom R, Mazzarella G, Lundin KE, Nilsen EM, Troncone R, MacDonald TT ( 2001 ) . Keratinocyte growth factor and coeliac disease . Gut vol. 49 , ( 2 ) 176 - 181 .

MacDonald T ( 2001 ) . Introduction . Seminars in Immunology vol. 13 , ( 3 ) 159 - 161 .

MacDonald TT, Monteleone G ( 2001 ) . IL-12 and Th1 immune responses in human Peyer's patches . Trends Immunol vol. 22 , ( 5 ) 244 - 247 .

Veitch AM, Kelly P, Zulu I, MacDonald TT, Farthing MJ ( 2001 ) . Lack of evidence for small intestinal mucosal T-cell activation as a pathogenic mechanism in African HIV-associated enteropathy . Dig Dis Sci vol. 46 , ( 5 ) 1133 - 1138 .

Salmela MT, Pender SLF, Reunala T, MacDonald T, Saarialho-Kere U ( 2001 ) . Parallel expression of macrophage metalloelastase (MMP-12) in duodenal and skin lesions of patients with dermatitis herpetiformis . GUT vol. 48 , ( 4 ) 496 - 502 .

Monteleone G, Pender SLF, Alstead E, Hauer AC, Lionetti P, McKenzie C, MacDonald TT ( 2001 ) . Role of interferon alpha in promoting T helper cell type 1 responses in the small intestine in coeliac disease (vol 48, pg 425, 2001) . GUT vol. 48 , ( 4 ) 584 - 584 .

Goncalves N, Simmons CP, Ghaem-Maghami M, Monteleone G, Frankel G, Dougan G, MacDonald TT ( 2001 ) . Increased susceptibility of TNFRp55 deficient mice to Citrobacter rodentium (mouse EPEC) infection . GUT vol. 48 , A75 - A75 .

Monteleone G, Pender SL, Alstead E, Hauer AC, Lionetti P, McKenzie C, MacDonald TT ( 2001 ) . Role of interferon alpha in promoting T helper cell type 1 responses in the small intestine in coeliac disease . Gut vol. 48 , ( 3 ) 425 - 429 .

Kumberova A, CROFT NM, MacDonald TT, Steer HW, Monteleone G, McKenzie C ( 2001 ) . Blocking Smad7 restores TGF-beta1 signalling in chronic inflammatory bowel disease . J. Clin. Invest. vol. 108 , ( 4 ) 601 - 609 .

MacDonald TT, Nagata S, Fairclough PD, McKenzie C ( 2001 ) . Mucosal immunity - A key to tolerance . NEW CONCEPTS IN PATHOLOGY AND TREATMENT OF AUTOIMMUNE DISORDERS . Editors: Pozzilli, C, Pozzilli, P, Kapp, JF , 89 - 99 .

MacDonald TT ( 2001 ) . Targets for inflammatory bowel disease - biological therapy . IBD AND SALICYLATES - 5 . Editors: Modigliani, R , vol. 24 , 61 - 65 .

Macdonald TT ( 2001 ) . The worm turns on Helicobacter pylori . Gut vol. 48 , ( 1 ) 10 - 11 .

Pender SLF, Salmela MT, Monteleone G, Schnapp D, McKenzie C, Spencer J, Fong S, Saarialho-Kere U et al. ( 2000 ) . Ligation of α4β1 Integrin on Human Intestinal Mucosal Mesenchymal Cells Selectively Up-Regulates Membrane Type-1 Matrix Metalloproteinase and Confers a Migratory Phenotype . American Journal Of Pathology vol. 157 , ( 6 ) 1955 - 1962 .

Pender SLF, Quinn JJ, Sanderson IR, MacDonald TT ( 2000 ) . Butyrate upregulates stromelysin-1 production by intestinal mesenchymal cells . AJP Gastrointestinal and Liver Physiology vol. 279 , ( 5 ) g918 - g924 .

Nagata S, McKenzie C, Pender SLF, Bajaj-Elliott M, Fairclough PD, Walker-Smith JA, Monteleone G, MacDonald TT ( 2000 ) . Human Peyer’s Patch T Cells Are Sensitized to Dietary Antigen and Display a Th Cell Type 1 Cytokine Profile . The Journal of Immunology vol. 165 , ( 9 ) 5315 - 5321 .

Egger B, Bajaj-Elliott M, MacDonald TT, Inglin R, Eysselein VE, Büchler MW ( 2000 ) . Characterisation of Acute Murine Dextran Sodium Sulphate Colitis: Cytokine Profile and Dose Dependency . Digestion vol. 62 , ( 4 ) 240 - 248 .

Hartland EL, Huter V, Higgins LM, Goncalves NS, Dougan G, Phillips AD, MacDonald TT, Frankel G ( 2000 ) . Expression of Intimin γ from EnterohemorrhagicEscherichia coli in Citrobacter rodentium . Infection and Immunity vol. 68 , ( 8 ) 4637 - 4646 .

Heuschkel RB, MacDonald TT, Monteleone G, Bajaj-Elliott M, Smith JA, Pender SL ( 2000 ) . Imbalance of stromelysin-1 and TIMP-1 in the mucosal lesions of children with inflammatory bowel disease . Gut vol. 47 , ( 1 )

MacDonald TT ( 1993 ) . T Cell‐Mediated Immunity and Tissue Damage in the Gut . Canadian Journal of Gastroenterology and Hepatology . vol. 7 , 87 - 90 .

Souza HS, Elia CC, Spencer J, MacDonald TT ( 1999 ) . Expression of lymphocyte-endothelial receptor-ligand pairs, α4β7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease . Gut vol. 45 , ( 6 )

Monteleone G, MacDonald TT, Wathen NC, Pallone F, Pender SLF ( 1999 ) . Enhancing lamina propria Th1 cell responses with interleukin 12 produces severe tissue injury . Gastroenterology vol. 117 , ( 5 ) 1069 - 1077 .

MacDonald TT, Bajaj-Elliott M, Pender SLF ( 1999 ) . T cells orchestrate intestinal mucosal shape and integrity . Trends in Immunology vol. 20 , ( 11 ) 505 - 510 .

Higgins LM, Frankel G, Connerton I, Gonçalves NS, Dougan G, MacDonald TT ( 1999 ) . Role of Bacterial Intimin in Colonic Hyperplasia and Inflammation . Science vol. 285 , ( 5427 ) 588 - 591 .

Higgins LM, Frankel G, Douce G, Dougan G, MacDonald TT ( 1999 ) . Citrobacter rodentium Infection in Mice Elicits a Mucosal Th1 Cytokine Response and Lesions Similar to Those in Murine Inflammatory Bowel Disease . Infection and Immunity vol. 67 , ( 6 ) 3031 - 3039 .

MacDonald TT ( 1999 ) . Effector and Regulatory Lymphoid Cells and Cytokines in Mucosal Sites . Current Topics in Microbiology and Immunology vol. 236 , 113 - 135 .

Fell JME, Paintin M, Donnet-Hughes A, Arnaud-Battandier F, MacDonald TT, Walker-Smith JA ( 1999 ) . Remission induced by a new specific oral polymeric diet in children with Crohn's disease . INFLAMMATORY BOWEL DISEASES . Editors: Bistrian, BR, WalkerSmith, JA , vol. 2 , 187 - 198 .

Lawrence CE, Paterson JCM, Higgins LM, MacDonald TT, Kennedy MW, Garside P ( 1998 ) . IL‐4‐regulated enteropathy in an intestinal nematode infection . European Journal of Immunology vol. 28 , ( 9 ) 2672 - 2684 .

MacDonald TT ( 1998 ) . Depletion of the enteric nervous system by gene targeting results in haemorrhagic necrosis of the ileum . Gut vol. 43 , ( 6 )

Howie D, Spencer J, DeLord D, Pitzalis C, Wathen NC, Dogan A, Akbar A, MacDonald TT ( 1998 ) . Extrathymic T cell differentiation in the human intestine early in life . The Journal of Immunology vol. 161 , ( 11 ) 5862 - 5872 .

MacDonald TT ( 1998 ) . T cell immunity to oral allergens . Current Opinion in Immunology vol. 10 , ( 6 ) 620 - 627 .

Bajaj-Elliott M, Poulsom R, Pender SL, Wathen NC, MacDonald TT ( 1998 ) . Interactions between stromal cell--derived keratinocyte growth factor and epithelial transforming growth factor in immune-mediated crypt cell hyperplasia . Journal of Clinical Investigation vol. 102 , ( 8 ) 1473 - 1480 .

Stallmach A, Strober W, MacDonald TT, Lochs H, Zeitz M ( 1998 ) . Induction and modulation of gastrointestinal inflammation . Trends in Immunology vol. 19 , ( 10 ) 438 - 441 .

Pender SLF, Breese EJ, Günther U, Howie D, Wathen NC, Schuppan D, MacDonald TT ( 1998 ) . Suppression of T cell–mediated injury in human gut by interleukin 10: Role of matrix metalloproteinases . Gastroenterology vol. 115 , ( 3 ) 573 - 583 .

MacDonald TT, Riecken E-O ( 1998 ) . Session Summary . Pathobiology . vol. 66 , 158 - 158 .

MacDonald TT, Pender SLF ( 1998 ) . Proteolytic Enzymes in Inflammatory Bowel Disease . Inflammatory Bowel Diseases vol. 4 , ( 2 ) 157 - 164 .

Pender SLF, Fell JME, Chamow SM, Ashkenazi A, MacDonald TT ( 1998 ) . A p55 TNF receptor immunoadhesin prevents T cell-mediated intestinal injury by inhibiting matrix metalloproteinase production . The Journal of Immunology vol. 160 , ( 8 ) 4098 - 4103 .

Perman JA, Beattie RM, Bentsen BS, Macdonald TT ( 1998 ) . Concepts in Pediatric Gastroenterology and Nutrition, Part IV: Childhood Crohn’s Disease and the Efficacy of Enteral Diets . Nutrition vol. 14 , ( 4 ) 345 - 350 .

Elliott M, Pender S, Poulsom R, MacDonald T ( 1998 ) . Keratinocyte growth factor (FGF-7) and its role in mediating the crypt hyperplasia seen during T cell hypersensitivity in the gut . Gastroenterology vol. 114 ,

Macdonald TT ( 1998 ) . Viral vectors expressing immunoregulatory cytokines to treat inflammatory bowel disease . Gut vol. 42 , ( 4 )

MacDonald TT ( 1998 ) . Preface . Chemical Immunology vol. 71 ,

Trajman A, MacDonald TT, Elia CC ( 1997 ) . Intestinal immune cells in Strongyloides stercoralis infection . Journal of Clinical Pathology vol. 50 , ( 12 )

Hauer AC, Finn TM, MacDonald TT, Spencer J, Isaacson PG ( 1997 ) . Analysis of TH1 and TH2 cytokine production in low grade B cell gastric MALT-type lymphomas stimulated in vitro with Helicobacter pylori . Journal of Clinical Pathology vol. 50 , ( 11 )

MacDonald TT ( 1997 ) . Cytokine gene deleted mice in the study of gastrointestinal inflammation . European Journal of Gastroenterology & Hepatology vol. 9 , ( 11 ) 1051 - 1055 .

Bajaj-Elliott M, Breese E, Poulsom R, Fairclough PD, MacDonald TT ( 1997 ) . Keratinocyte growth factor in inflammatory bowel disease. Increased mRNA transcripts in ulcerative colitis compared with Crohn's disease in biopsies and isolated mucosal myofibroblasts . American Journal Of Pathology vol. 151 , ( 5 ) 1469 - 1476 .

MacDonald TT ( 1997 ) . Oxpentifylline, tumour necrosis factor-alpha and Crohn's disease . Gut vol. 40 , ( 4 )

Pender SL, Tickle SP, Docherty AJ, Howie D, Wathen NC, MacDonald TT ( 1997 ) . A major role for matrix metalloproteinases in T cell injury in the gut . The Journal of Immunology vol. 158 , ( 4 ) 1582 - 1590 .

Murch SH, Costeloe K, Klein NJ, MacDonald TT ( 1996 ) . Early Production of Macrophage Inflammatory Protein-1α Occurs in Respiratory Distress Syndrome and Is Associated with Poor Outcome . Pediatric Research vol. 40 , ( 3 ) 490 - 497 .

Murch SH, Costeloe K, Klein NJ, Rees H, McIntosh N, Keeling JW, MacDonald TT ( 1996 ) . Mucosal Tumor Necrosis Factor-α Production and Extensive Disruption of Sulfated Glycosaminoglycans Begin within Hours of Birth in Neonatal Respiratory Distress Syndrome . Pediatric Research vol. 40 , ( 3 ) 484 - 489 .

Braegger CP, Spencer J, MacDonald TT ( 1996 ) . Ontogenetic aspects of the intestinal immune system in man . International Journal of Clinical and Laboratory Research vol. 26 , ( 3 ) 1 - 4 .

Pender SL, Lionetti P, Murch SH, Wathan N, MacDonald TT ( 1996 ) . Proteolytic degradation of intestinal mucosal extracellular matrix after lamina propria T cell activation . Gut vol. 39 , ( 2 )

Braegger CP, Spencer J, MacDonald TT ( 1996 ) . Ontogenetic aspects of the intestinal immune system in man . International Journal of Clinical and Laboratory Research vol. 26 , ( 2 ) 1 - 4 .

Braegger CP, MacDonald TT ( 1996 ) . The immunologic basis for celiac disease and related disorders . Seminars in Gastrointestinal Disease vol. 7 , ( 3 ) 124 - 133 .

Breese EJ, Bajaj-Elliott M, MacDonald TT ( 1996 ) . 171 EXPRESSION OF MATRIX METALLOPROTEINASE mRNA BY SMOOTH MUSCLE CELLS ISOLATED FROM THE MUCOSA OF CHILDREN WITH INFLAMMATORY BOWEL DISEASE . Journal of Pediatric Gastroenterology and Nutrition vol. 22 , ( 4 )

Thomas R, Schürmann G, Lionetti P, Pender SL, MacDonald TT ( 1996 ) . T cell receptor V beta expression in human intestine: regional variation in postnatal intestine and biased usage in fetal gut . Gut vol. 38 , ( 2 )

Braegger CP, Spencer J, MacDonald TT ( 1995 ) . Ontogenetic aspects of the intestinal immune system in man . International Journal of Clinical and Laboratory Research vol. 25 , ( 4 ) 1 - 4 .

Penney L, Kilshaw PJ, MacDonald TT ( 1995 ) . Regional variation in the proliferative rate and lifespan of alpha beta TCR+ and gamma delta TCR+ intraepithelial lymphocytes in the murine small intestine . Immunology vol. 86 , ( 2 ) 212 - 218 .

Karttunen R, Karttunen T, Ekre HP, MacDonald TT ( 1995 ) . Interferon gamma and interleukin 4 secreting cells in the gastric antrum in Helicobacter pylori positive and negative gastritis . Gut vol. 36 , ( 3 )

Taylor J, MacDonald TT, Spencer J ( 1995 ) . 4D5.4, a monoclonal antibody which recognizes cells in inflamed human intestine . vol. 371B , 1331 - 1332 .

Murch SH, Braegger CP, Walker-Smith JA, MacDonald TT ( 1995 ) . Distribution and density of TNF immunoreactivity in chronic inflammatory bowel disease . vol. 371B , 1327 - 1330 .

Dogan A, MacDonald TT, Spencer J ( 1995 ) . Expression of Cell Adhesion Molecules in the Fetal Gut . Advances in Experimental Medicine and Biology . vol. 371A , 141 - 143 .

Lionetti P, Murch SH, Taylor J, MacDonald TT ( 1995 ) . Mucosal Adaptation and Destruction in Response to Lamina Propria T Cell Activation in Explants of Human Fetal Intestine . Advances in Experimental Medicine and Biology vol. 371A , 493 - 496 .

Breese E, MacDonald TT ( 1995 ) . TNF alpha secreting cells in normal and diseased human intestine . vol. 371B , 821 - 824 .

Karttunnen R, Breese EJ, Walker-Smith JA, MacDonald TT ( 1994 ) . Decreased mucosal interleukin-4 (IL-4) production in gut inflammation . Journal of Clinical Pathology vol. 47 , ( 11 )

MacDonald TT ( 1994 ) . Inflammatory bowel disease in children . Current Opinion in Pediatrics vol. 6 , ( 5 ) 547 - 555 .

Breese EJ, Kumar P, Farthing MJ, MacDonald TT ( 1994 ) . Interleukin-2 and interferon-γ producing cells in the lamina propria in celiac disease . Digestive Diseases and Sciences vol. 39 , ( 10 ) 2243 - 2243 .

Nicholls S, Domizio P, Williams CB, Dawnay A, Braegger CP, MacDonald TT, Walker-Smith JA ( 1994 ) . Cyclosporin as initial treatment for Crohn's disease . Archives of Disease in Childhood vol. 71 , ( 3 )

( 1994 ) . Macrophage-associated chemokines and cytokines in neonatal respiratory distress syndrome Simon Murch, Thomas MacDonald and Kate Costeloe, Department of Paediatric Gastroenterology, St Bartholomew's Hospital and Department of Neonatal Medicine, Homerton Hospital, London, UK . Early Human Development . vol. 38 ,

MacDonald TT, Spencer J, Murch SH, Choy M-Y, Venugopal S, Bundy DAP, Cooper ES ( 1994 ) . 3. Mucosal macrophages and cytokine production in the colon of children with Trichuris trichiura dysentery . Transactions of the Royal Society of Tropical Medicine and Hygiene vol. 88 , ( 3 ) 265 - 268 .

MacDonald TT, Murch SH ( 1994 ) . Aetiology and pathogenesis of chronic inflammatory bowel disease . Best Practice & Research Clinical Gastroenterology vol. 8 , ( 1 ) 1 - 34 .

Walker-Smith JA, Macdonald TT ( 1994 ) . Foreword . Best Practice & Research Clinical Gastroenterology vol. 8 , ( 1 ) ix - x .

Macdonald TT ( 1994 ) . Gastrointestinal Inflammation: Inflammatory bowel disease in knockout mice . Current Biology vol. 4 , ( 3 ) 261 - 263 .

Batman PA, Fleming SC, Sedgwick PM, MacDonald TT, Griffin GE ( 1994 ) . HIV infection of human fetal intestinal explant cultures induces epithelial cell proliferation . AIDS vol. 8 , ( 2 ) 153 - 160 .

Braegger CP, MacDonald TT ( 1994 ) . Immune mechanisms in chronic inflammatory bowel disease . Annals of Allergy Asthma & Immunology vol. 72 , ( 2 ) 135 - 141 .

Macdonald TT ( 1994 ) . Oral Tolerance: Eating your way towards immunosuppression . Current Biology vol. 4 , ( 2 ) 178 - 181 .

Walker-Smith JA, Macdonald TT ( 1994 ) . Foreword . Bailliere's Clinical Gastroenterology vol. 8 , ( 1 )

Murch SH, Braegger CP, Walker-Smith JA, MacDonald TT ( 1993 ) . Location of tumour necrosis factor alpha by immunohistochemistry in chronic inflammatory bowel disease . Gut vol. 34 , ( 12 )

MacDonald TT, Spencer J ( 1993 ) . Development of gastrointestinal immune function and its relationship to intestinal disease . Current Opinion in Gastroenterology vol. 9 , ( 6 ) 946 - 952 .

Nicholls S, Stephens S, Braegger CP, Walker-Smith JA, MacDonald TT ( 1993 ) . Cytokines in stools of children with inflammatory bowel disease or infective diarrhoea . Journal of Clinical Pathology vol. 46 , ( 8 )

Lionetti P, Breese E, Braegger CP, Murch SH, Taylor J, MacDonald TT ( 1993 ) . T-cell activation can induce either mucosal destruction or adaptation in cultured human fetal small intestine . Gastroenterology vol. 105 , ( 2 ) 373 - 381 .

MacDonald TT ( 1993 ) . Aetiology of Crohn's disease . Archives of Disease in Childhood vol. 68 , ( 5 )

Murch SH, MacDonald TT, Walker-Smith JA, Lionetti P, Levin M, Klein NJ ( 1993 ) . Disruption of sulphated glycosaminoglycans in intestinal inflammation . The Lancet vol. 341 , ( 8847 ) 711 - 714 .

Tsuji M, Puri P, Reen DJ ( 1993 ) . Characterisation of the Local Inflammatory Response in Appendicitis . Journal of Pediatric Gastroenterology and Nutrition vol. 16 , ( 1 ) 43 - 48 .

Breese E, Braegger CP, Corrigan CJ, Walker-Smith JA, MacDonald TT ( 1993 ) . Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa . Immunology vol. 78 , ( 1 ) 127 - 131 .

MacDonald TT ( 1992 ) . Celiac disease (gluten-sensitive enteropathy) . Clinical and Applied Immunology Reviews vol. 12 , ( 10-11 ) 156 - 161 .

Fleming SC, Kapembwa MS, MacDonald TT, Griffin GE ( 1992 ) . Direct in vitro infection of human intestine with HIV-1 . AIDS vol. 6 , ( 10 ) 1099 - 1104 .

Viney JL, MacDonald TT ( 1992 ) . Lymphokine secretion and proliferation of intraepithelial lymphocytes from murine small intestine . Immunology vol. 77 , ( 1 ) 19 - 24 .

MacDonald TT, Spencer J ( 1992 ) . CELL-MEDIATED IMMUNE INJURY IN THE INTESTINE . Gastroenterology Clinics of North America vol. 21 , ( 2 ) 367 - 386 .

Braegger CP, Spencer J, MacDonald TT ( 1992 ) . Ontogenetic aspects of the intestinal immune system in man . International Journal of Clinical and Laboratory Research vol. 22 , ( 1-4 ) 1 - 4 .

Evans CM, Phillips AD, Walker-Smith JA, MacDonald TT ( 1992 ) . Activation of lamina propria T cells induces crypt epithelial proliferation and goblet cell depletion in cultured human fetal colon . Gut vol. 33 , ( 2 )

Murch SH, Braegger CP, MacDonald TT, Sessa WC ( 1992 ) . High endothelin-1 immunoreactivity in Crohn's disease and ulcerative colitis . The Lancet vol. 339 , ( 8790 ) 381 - 385 .

( 1992 ) . The European Society for Paediatric Gastroenterology and Nutrition Working Group for the Diagnostic Criteria for Food Allergy* . Journal of Pediatric Gastroenterology and Nutrition vol. 14 , ( 1 ) 108 - 112 .

MacDonald TT ( 1992 ) . The mucosal immune system in human immunodeficiency virus infection . European Journal of Gastroenterology and Hepatology vol. 4 , ( 6 ) 390 - 395 .

Braegger CP, Nicholls S, Murch SH, MacDonald TT, Stephens S ( 1992 ) . Tumour necrosis factor alpha in stool as a marker of intestinal inflammation . The Lancet vol. 339 , ( 8785 ) 89 - 91 .

Murch SH, MacDonald TT, Wood CB, Costeloe KL ( 1992 ) . Tumour necrosis factor in the bronchoalveolar secretions of infants with the respiratory distress syndrome and the effect of dexamethasone treatment . Thorax vol. 47 , ( 1 )

Cooper ES, Bundy DAP, Whyte-Alleng CAM, Venugopal S, Spencer J, Whitney P, Cromwell O, Haynes B et al. ( 1991 ) . Immediate hypersensitivity in colon of children with chronic Trichuris trichiura dysentery . The Lancet vol. 338 , ( 8775 ) 1104 - 1107 .

Spencer J, Choy MY, MacDonald TT ( 1991 ) . T cell receptor V beta expression by mucosal T cells . Journal of Clinical Pathology vol. 44 , ( 11 )

Murch SH, Lamkin VA, Savage MO, Walker-Smith JA, MacDonald TT ( 1991 ) . Serum concentrations of tumour necrosis factor alpha in childhood chronic inflammatory bowel disease . Gut vol. 32 , ( 8 )

Mahida YR ( 1991 ) . Interleukin-2 receptor expression . Gut vol. 32 , ( 4 )

MacDonald TT, Choy MY, Spencer J, Richman PI, Diss T, Hanchard B, Venugopal S, Bundy DA et al. ( 1991 ) . Histopathology and immunohistochemistry of the caecum in children with the Trichuris dysentery syndrome . Journal of Clinical Pathology vol. 44 , ( 3 )

Choy MY, Walker-Smith JA, Williams CB, MacDonald TT ( 1990 ) . Differential expression of CD25 (interleukin-2 receptor) on lamina propria T cells and macrophages in the intestinal lesions in Crohn's disease and ulcerative colitis . Gut vol. 31 , ( 12 )

Shepherd N, Levison D, Heatley RV, Braegger C, Corrigan C, Macdonald T, Ghoda MK ( 1990 ) . Toothpaste and Crohn's disease . The Lancet vol. 336 , ( 8727 )

Murch S, Macdonald T, Goldin RD, Hunt NCA, Riches P, Gooding R ( 1990 ) . In-vitro production of cytokines in serum . The Lancet vol. 336 , ( 8716 ) 687 - 688 .

Viney J, MacDonald TT, Spencer J ( 1990 ) . Gamma/delta T cells in the gut epithelium . Gut vol. 31 , ( 8 )

MacDonald TT, Spencer J ( 1990 ) . Ontogeny of the mucosal immune response . Seminars in Immunopathology vol. 12 , ( 2-3 ) 129 - 137 .

Macdonald TT, Spencer J ( 1990 ) . Gut immunology . Best Practice & Research Clinical Gastroenterology vol. 4 , ( 2 ) 291 - 313 .

da Cunha Ferreira R, Forsyth LE, Richman PI, Wells C, Spencer J, Macdonald TT ( 1990 ) . Changes in the Rate of Crypt Epithelial Cell Proliferation and Mucosal Morphology Induced by a T-Cell-Mediated Response in Human Small Intestine . Gastroenterology vol. 98 , ( 5 ) 1255 - 1263 .

Cooper ES, Bundy DA, MacDonald TT, Golden MH ( 1990 ) . Growth suppression in the Trichuris dysentery syndrome . European Journal of Clinical Nutrition vol. 44 , ( 4 ) 285 - 291 .

MacDonald TT, Horton MA, Choy MY, Richman PI ( 1990 ) . Increased expression of laminin/collagen receptor (VLA-1) on epithelium of inflamed human intestine . Journal of Clinical Pathology vol. 43 , ( 4 )

Walker-Smith J, MacDonald T ( 1989 ) . Insights provided by the study of the small intestine in the child and the foetus . Gut vol. 30 , ( Spec No )

Viney JL, MacDonald TT, Kilshaw PJ ( 1989 ) . αβ T cell receptor expression in rat intestinal epithelium . Immunology Letters vol. 23 , ( 1 ) 49 - 53 .

Viney JL, MacDonald TT, Kilshaw PJ ( 1989 ) . T-cell receptor expression in intestinal intra-epithelial lymphocyte subpopulations of normal and athymic mice . Immunology vol. 66 , ( 4 ) 583 - 587 .

Spencer J, MacDonald TT, Diss TC, Walker-Smith JA, Ciclitira PJ, Isaacson PG ( 1989 ) . Changes in intraepithelial lymphocyte subpopulations in coeliac disease and enteropathy associated T cell lymphoma (malignant histiocytosis of the intestine) . Gut vol. 30 , ( 3 )

Monk T, Spencer J, Cerf-Bensussan N, MacDonald TT ( 1988 ) . Stimulation of mucosal T cells in situ with anti-CD3 antibody: location of the activated T cells and their distribution within the mucosal micro-environment . Clinical & Experimental Immunology vol. 74 , ( 2 ) 216 - 222 .

MacDonald TT, Weinel A, Spencer J ( 1988 ) . HLA-DR expression in human fetal intestinal epithelium . Gut vol. 29 , ( 10 )

MacDonald TT, Spencer J ( 1988 ) . Evidence that activated mucosal T cells play a role in the pathogenesis of enteropathy in human small intestine . Journal of Experimental Medicine vol. 167 , ( 4 ) 1341 - 1349 .

Crane MS, Murray PK, Gnozzio MJ, MacDonald TT ( 1988 ) . Passive protection of chickens against Eimeria tenella infection by monoclonal antibody . Infection and Immunity vol. 56 , ( 4 ) 972 - 976 .

Hancock GE, Schaedler RW, MacDonald TT ( 1988 ) . Multigenic control of resistance to Yersinia enterocolitica in inbred strains of mice . Infection and Immunity vol. 56 , ( 2 ) 532 - 533 .

MacDonald TT, Spencer J, Viney JL, Williams CB, Walker-Smith JA ( 1987 ) . Selective biopsy of human Peyer's patches during ileal endoscopy . Gastroenterology vol. 93 , ( 6 ) 1356 - 1362 .

Walker-Smith JA, MacDonald TT ( 1987 ) . Intestinal lymphoid cells . Digestive Diseases and Sciences vol. 32 , ( 7 ) 782 - 782 .

Spencer J, MacDonald TT, Isaacson PG ( 1987 ) . Heterogeneity of non-lymphoid cells expressing HLA-D region antigens in human fetal gut . Clinical & Experimental Immunology vol. 67 , ( 2 ) 415 - 424 .

Spencer J, MacDonald TT, Isaacson PG ( 1987 ) . Development of human gut-associated lymphoid tissue . vol. 216B , 1421 - 1430 .

Dillon SB, Dalton BJ, MacDonald TT ( 1986 ) . Lymphokine production by mitogen and antigen activated mouse intraepithelial lymphocytes . Cellular Immunology vol. 103 , ( 2 ) 326 - 338 .

Dillon SB, MacDonald TT ( 1986 ) . Functional characterization of Con A-responsive Lyt2-positive mouse small intestinal intraepithelial lymphocytes . Immunology vol. 59 , ( 3 ) 389 - 396 .

MacDonald TT, Calkins CE, Rothermel AL ( 1986 ) . Modulation in vivo of Lyt 2 antigen expression on T cells by anti-Lyt 2 antibody: effects on Con A-induced unresponsiveness . Immunology vol. 59 , ( 2 ) 181 - 186 .

Spencer J, Dillon SB, Isaacson PG, MacDonald TT ( 1986 ) . T cell subclasses in fetal human ileum . Clinical & Experimental Immunology vol. 65 , ( 3 ) 553 - 558 .

Zemcik BA, Murray PK, MacDonald TT ( 1986 ) . Detection of chicken antibody to the protozoan parasite Eimeria tenella by antigen-coated microspheres . Journal of Immunological Methods vol. 91 , ( 2 ) 265 - 269 .

Macdonald TT, Spencer J, Viney J, Williams C, Walker-Smith JA ( 1986 ) . FUNCTIONAL STUDIES ON CELLS FROM HUMAN PEYER'S PATCHES. THEIR PHENOTYPE AND IN VITRO PROLIFERATIVE RESPONSES . Pediatric Research vol. 20 , ( 7 ) 689 - 689 .

Hancock GE, Schaedler RW, MacDonald TT ( 1986 ) . Yersinia enterocolitica infection in resistant and susceptible strains of mice . Infection and Immunity vol. 53 , ( 1 ) 26 - 31 .

Spencer J, MacDonald TT, Finn T, Isaacson PG ( 1986 ) . The development of gut associated lymphoid tissue in the terminal ileum of fetal human intestine . Clinical & Experimental Immunology vol. 64 , ( 3 ) 536 - 543 .

Anderson AO, MacDonald TT, Rubin DH ( 1985 ) . Effect of orally administered avridine on enteric antigen uptake and mucosal immunity . International Journal of Immunotherapy vol. 1 , ( 2 ) 107 - 115 .

Dillon SB, MacDonald TT ( 1985 ) . Isolation and function of mucosal lymphocytes in the mouse . Progress in Clinical and Biological Research vol. 181 , 381 - 385 .

Dillon SB, MacDonald TT ( 1985 ) . Lymphokine Production by T Lymphocytes Isolated from Murine Small Intestinal Epithelium . Microenvironments in the Lymphoid System , vol. 186 , Springer Nature

Dillon SB, MacDonald TT ( 1985 ) . Lymphokine production by T lymphocytes isolated from murine small intestinal epithelium . vol. 186 , 701 - 711 .

Dillon SB, MacDonald TT ( 1985 ) . Lymphokine production by mitogen or antigen activated intraepithelial lymphocytes from mouse small intestine . Federation Proceedings vol. 44 , ( 4 )

Hancock GE, MacDonald TT ( 1985 ) . Natural resistance in murine yersiniosis . Federation Proceedings vol. 44 , ( 3 )

Dillon SB, MacDonald TT ( 1984 ) . Functional properties of lymphocytes isolated from murine small intestinal epithelium . Immunology vol. 52 , ( 3 ) 501 - 509 .

MacDonald TT ( 1982 ) . Enhancement and suppression of the Peyer's patch immune response by systemic priming . Clinical & Experimental Immunology vol. 49 , ( 2 ) 441 - 448 .

MacDonald TT, Bashore M, Carter PB ( 1982 ) . Nonspecific resistance to infection expressed within the Peyer's patches of the small intestine . Infection and Immunity vol. 37 , ( 1 ) 390 - 392 .

MacDonald TT, Carter PB ( 1982 ) . Isolation and functional characteristics of adherent phagocytic cells from mouse Peyer's patches . Immunology vol. 45 , ( 4 ) 769 - 774 .

MacDonald TT ( 1982 ) . Cell-Interactions in the Splenic Suppression Caused by Antigen-Feeding . Advances in Experimental Medicine and Biology vol. 149 , 659 - 668 .

Murphy JR, Carter PB, MacDonald TT ( 1980 ) . Host defenses in murine malaria: failure of vaccination with formolized blood parasites to protect athymic mice from Plasmodium berghei . Infection and Immunity vol. 29 , ( 2 ) 827 - 830 .

MacDonald TT, Carter PB ( 1980 ) . Cell-mediated immunity to intestinal infection . Infection and Immunity vol. 28 , ( 2 ) 516 - 523 .

MacDonald TT, Murray M, Ferguson A ( 1980 ) . Nippostrongylus brasiliensis: Mast cell kinetics at small intestinal sites in infected rats . Experimental Parasitology vol. 49 , ( 1 ) 9 - 14 .

Ferguson A, Logan RF, MacDonald TT ( 1980 ) . Increased mucosal damage during parasite infection in mice fed an elemental diet . Gut vol. 21 , ( 1 )

MacDonald TT, Carter PB ( 1979 ) . Requirement for a bacterial flora before mice generate cells capable of mediating the delayed hypersensitivity reaction to sheep red blood cells . The Journal of Immunology vol. 122 , ( 6 ) 2624 - 2629 .

Carter PB, MacDonald TT, Collins FM ( 1979 ) . Host responses to infection with Yersinia enterocolitica . Bibliotheca Microbiologica vol. 5 , 346 - 350 .

MacDonald TT, Carter PB, Phillips PG ( 1979 ) . Modulation of cellular immunity by the enteric flora: Delayed type hypersensitivity in the gnotobiotic mouse . Zentralblatt fur Bakteriologie Mikrobiologie und Hygiene - Abt. 1 Orig. A vol. 245 , ( Suppl. 7 ) 221 - 226 .

MacDonald TT, Carter PB ( 1978 ) . Contact sensitivity in the germ-free mouse . Journal of Leukocyte Biology vol. 24 , ( 3 ) 287 - 293 .

MACDONALD TT, CARTER PB ( 1978 ) . MOUSE PEYER'S PATCHES CONTAIN T CELLS CAPABLE OF INDUCING THE GRAFT-VERSUS-HOST REACTION (GVHR) . Transplantation vol. 26 , ( 3 ) 162 - 165 .

Scott MT, MacDonald TT, Carter PB ( 1978 ) . C. parvum in germ-free mice . Cancer Immunology, Immunotherapy vol. 4 , ( 2 ) 135 - 137 .

MacDonald TT, Ferguson A ( 1978 ) . Small intestinal epithelial cell kinetics and protozoal infection in mice . Gastroenterology vol. 74 , ( 3 ) 496 - 500 .

Ferguson A, Paul G, MacDonald TT ( 1978 ) . Immunodeficiency and fatty liver in mice reared on an elemental diet . Arquivos de Gastroenterologia vol. 15 , ( 1 ) 11 - 15 .

Ferguson A, Sutherland A, MacDonald TT, Allan F ( 1977 ) . Technique for microdissection and measurement in biopsies of human small intestine . Journal of Clinical Pathology vol. 30 , ( 11 )

MacDonald TT, Ferguson A ( 1976 ) . Hypersensitivity reactions in the small intestine. 2. Effects of allograft rejection on mucosal architecture and lymphoid cell infiltrate . Gut vol. 17 , ( 2 )

Ferguson A, Mcclure JP, Macdonald TT, Holden RJ ( 1975 ) . CELL-MEDIATED IMMUNITY TO GLIADIN WITHIN THE SMALL-INTESTINAL MUCOSA IN CŒLIAC DISEASE . The Lancet vol. 305 , ( 7912 ) 895 - 897 .

Ferguson A, MacDonald TT ( 1975 ) . Activated T lymphocytes in clinical and experimental small bowel disease . Acta Paediatrica Scandinavica vol. 64 , ( 1 )

Ferguson A, MacDonald TT ( 1975 ) . Effects of local hypersensitivity reactions on small intestinal morphology . BEHRING INST.MITT. vol. No. 57 , 118 - 121 .