Publications:  Prof Ian MacKenzie

MACKENZIE IC, Rodrigues MF, Gammon L, RAHMAN M, BIDDLE A, Nunes FD(2018). Effects of Cetuximab and Erlotinib on the behaviour of cancer stem cells in head and neck squamous cell carcinoma. Oncotarget

Rodini CO, Lopes NM, Lara VS, Mackenzie IC(2017). Oral cancer stem cells - properties and consequences. J Appl Oral Sci vol. 25, (6) 708-715.

Vig NK, Gammon L, Peyric E, Rahman M, Biddle A, Mackenzie IC (2017). The amoeboid cell in cancer. BRITISH JOURNAL OF SURGERY. vol. 104, 43-43.

Vig N, Rahman M, Gammon L, Peyric E, Mackenzie I (2017). Investigation of the properties of the amoeboid cell, a new cell type in oral cancer. LANCET. vol. 389, 97-97.

Gammon L, Mackenzie IC(2016). Roles of hypoxia, stem cells and epithelial-mesenchymal transition in the spread and treatment resistance of head and neck cancer. J Oral Pathol Med vol. 45, (2) 77-82.

BIDDLE A, Gammon L, Liang X, Costea DE, Mackenzie IC(2016). Phenotypic Plasticity Determines Cancer Stem Cell Therapeutic Resistance in Oral Squamous Cell Carcinoma. EBioMedicine

Gemenetzidis E, Gammon L, Biddle A, Emich H, Mackenzie IC(2015). Invasive oral cancer stem cells display resistance to ionising radiation. Oncotarget vol. 6, (41) 43964-43977.

Vig N, Mackenzie IC, Biddle A(2015). Phenotypic plasticity and epithelial-to-mesenchymal transition in the behaviour and therapeutic response of oral squamous cell carcinoma. J Oral Pathol Med vol. 44, (9) 649-655.

Jensen DH, Reibel J, Mackenzie IC, Dabelsteen E(2015). Single cell migration in oral squamous cell carcinoma - possible evidence of epithelial-mesenchymal transition in vivo. J Oral Pathol Med vol. 44, (9) 674-679.

Emich H, Chapireau D, Hutchison I, Mackenzie I(2015). The potential of CD44 as a diagnostic and prognostic tool in oral cancer. J Oral Pathol Med vol. 44, (6) 393-400.

Shigeishi H, Biddle A, Gammon L, Rodini CO, Yamasaki M, Seino S, Sugiyama M, Takechi M et al.(2015). Elevation in 5-FU-induced apoptosis in head and neck cancer stem cells by a combination of CDHP and GSK3β inhibitors. J Oral Pathol Med vol. 44, (3) 201-207.

Nguyen NT, Mackenzie I, Teh M, Waseem A (2015). HOXA7 suppresses keratinocyte differentiation via PKC/AP-1 pathway. MOLECULAR BIOLOGY OF THE CELL. vol. 26,

Cicho¿ MA, Szentpetery Z, Caley MP, Papadakis ES, Mackenzie IC, Brennan CH, O'Toole EA(2014). The receptor tyrosine kinase Axl regulates cell-cell adhesion and stemness in cutaneous squamous cell carcinoma. Oncogene vol. 33, (32) 4185-4192.

Hufbauer M, Biddle A, Borgogna C, Gariglio M, Doorbar J, Storey A, Pfister H, Mackenzie I et al.(2013). Expression of Betapapillomavirus Oncogenes Increases the Number of Keratinocytes with Stem Cell-Like Properties. JOURNAL OF VIROLOGY vol. 87, (22) 12158-12165.

Kidwai F, Costea DE, Hutchison I, Mackenzie I(2013). The effects of CD44 down-regulation on stem cell properties of head and neck cancer cell lines. JOURNAL OF ORAL PATHOLOGY & MEDICINE vol. 42, (9) 682-690.

Bose A, Teh M-T, Mackenzie IC, Waseem A(2013). Keratin k15 as a biomarker of epidermal stem cells. Int J Mol Sci vol. 14, (10) 19385-19398.

Shigeishi H, Biddle A, Gammon L, Emich H, Rodini CO, Gemenetzidis E, Fazil B, Sugiyama M et al.(2013). Maintenance of Stem cell Self-renewal in Head and Neck Cancers Requires Actions of GSK3β Influenced by CD44 and RHAMM. Stem Cells vol. 31, (10) 2073-2083.

Biddle A, Gammon L, Fazil B, Mackenzie IC(2013). CD44 staining of cancer stem-like cells is influenced by down-regulation of CD44 variant isoforms and up-regulation of the standard CD44 isoform in the population of cells that have undergone epithelial-to-mesenchymal transition. PLoS One vol. 8, (2)

Gammon L, Biddle A, Heywood HK, Johannessen AC, Mackenzie IC(2013). Sub-sets of cancer stem cells differ intrinsically in their patterns of oxygen metabolism. PLoS One vol. 8, (4)

Biddle A, Mackenzie IC(2012). Cancer stem cells and EMT in carcinoma. Cancer Metastasis Rev

Wray H, Mackenzie I, Storey A, Navsaria H(2012). a6 Integrin and CD44 Enrich for a Primary Keratinocyte Population that Displays Resistance to UV-induced Apoptosis. PLoS One vol. 7, (10)

Biddle A, Liang X, Gammon L, Fazil B, Harper LJ, Emich H, Costea DE, Mackenzie IC(2011). Cancer stem cells in squamous cell carcinoma switch between two distinct phenotypes that are preferentially migratory or proliferative. Cancer Res vol. 71, (15) 5317-5326.

Cichon MA, Mackenzie IC, O'Toole EA (2011). Axl plays a role in cell adhesion and 'stemness' in cutaneous SCC. BRITISH JOURNAL OF DERMATOLOGY. vol. 164, 908-909.

Thode C, Jørgensen TG, Dabelsteen E, Mackenzie I, Dabelsteen S(2011). Significance of myofibroblasts in oral squamous cell carcinoma. J Oral Pathol Med vol. 40, (3) 201-207.

Gammon L, Biddle A, Fazil B, Harper L, Mackenzie IC(2011). Stem cell characteristics of cell sub-populations in cell lines derived from head and neck cancers of Fanconi anemia patients. J Oral Pathol Med vol. 40, (2) 143-152.

Cichon M, Mackenzie I, O'Toole E (2010). The role of the receptor tyrosine kinase Axl in intercellular adhesion and signalling in cutaneous squamous cell carcinoma. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 130, S15-S15.

Harper LJ, Costea DE, Gammon L, Fazil B, Biddle A, Mackenzie IC(2010). Normal and malignant epithelial cells with stem-like properties have an extended G2 cell cycle phase that is associated with apoptotic resistance. BMC Cancer vol. 10,

Cichon MA, Mackenzie IC, O'Toole EA (2010). The role of the receptor tyrosine kinase Axl in cell-cell adhesion and signaling in cancer. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 130, S34-S34.

Cichon MA, Mackenzie IC, O'Toole EA (2010). The role of the receptor tyrosine kinase Axl in intercellular adhesion and signalling in cancer. BRITISH JOURNAL OF DERMATOLOGY. vol. 162, 922-922.

Cichon MA, Papadakis ES, Mackenzie IC, O'Toole EA (2009). The role of the receptor tyrosine kinase, Axl, in intercellular adhesion and signalling in cutaneous squamous cell carcinoma. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 129, S79-S79.

Costea DE, Harper L, Gammon L, Mackenzie I(2009). Carcinoma cells expressing stem cell markers show selective survival associated with apoptotic resistance and cell cycle changes. CANCER RESEARCH vol. 69,

Cichon MA, Papadakis ES, MacKenzie IC, O'Toole EA (2009). The role of the receptor tyrosine kinase, Axl, intercellular adhesion and signalling in cancer. BRITISH JOURNAL OF DERMATOLOGY. vol. 160, 914-914.

Mackenzie IC (2008). Cancer stem cells. Ann Oncol. vol. 19 Suppl 5, v40-v43.

Costea DE, Gammon L, Kitajima K, Harper L, Mackenzie IC (2008). Epithelial stem cells and malignancy. JOURNAL OF ANATOMY. vol. 213, 45-51.

Locke M, Hyland PL, Irwin CR, Mackenzie IC(2008). Modulation of gingival epithelial phenotypes by interactions with regionally defined populations of fibroblasts. J Periodontal Res vol. 43, (3) 279-289.

Costea D, Harper L, Kitajima K, Mackenzie IC (2008). Generation of skin and oral mucosa from mouse embryonic stem cells under the influence of regional specific components. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 128, S145-S145.

Costea DE, Gammon L, Kitajima K, Harper L, Mackenzie IC(2008). Epithelial stem cells and malignancy. Journal of Anatomy vol. 213, (1) 45-51.

Mackenzie I(2008). Epithelial stem cells in health and disease. J ANAT vol. 212, (1) 77-77.

Harper LJ, Piper K, Common J, Fortune F, Mackenzie IC(2007). Stem cell patterns in cell lines derived from head and neck squamous cell carcinoma. J Oral Pathol Med vol. 36, (10) 594-603.

Tudor D, Chaudry F, Harper L, Mackenzie IC(2007). The in vitro behaviour and patterns of colony formation of murine epithelial stem cells. Cell Prolif vol. 40, (5) 706-720.

Nilsson H, Costea DE, Otterlei MK, Neppelberg E, Vintermyr OK, Mackenzie I, Johannessen AC (2007). Oral squamous cell carcinoma cells inhibit the growth of normal oral keratinocytes: a putative mechanism for intraepithelial tumour expansion. ORAL ONCOLOGY. vol. 2, 73-73.

Fairfax E, Harper L, Mackenzie I(2007). Patterns of apoptosis in malignant cell lines. BRIT J HOSP MED vol. 68, (3) M49-M49.

Costea DE, Tsinkalovsky O, Vintermyr OK, Johannessen AC, Mackenzie IC(2006). Cancer stem cells - new and potentially important targets for the therapy of oral squamous cell carcinoma (vol 12, pg 443, 2006). ORAL DIS vol. 12, (6) 584-584.

Costea DE, Tsinkalovsky O, Vintermyr OK, Johannessen AC, Mackenzie IC(2006). Cancer stem cells - new and potentially important targets for the therapy of oral squamous cell carcinoma. Oral Dis vol. 12, (5) 443-454.

Mackenzie IC(2006). Stem cell properties and epithelial malignancies. Eur J Cancer vol. 42, (9) 1204-1212.

Britt-Compton B, Rowson J, Locke M, Mackenzie I, Kipling D, Baird DM(2006). Structural stability and chromosome-specific telomere length is governed by cis-acting determinants in humans. HUM MOL GENET vol. 15, (5) 725-733.

MACKENZIE I, Dabelsteen S(2006). The stem cell concept in oral mucosa and in cancer. Nor Tannlegeforen Tid vol. 116, 32-36.

Mackenzie IC(2005). Retention of stem cell patterns in malignant cell lines. Cell Prolif vol. 38, (6) 347-355.

Locke M, Heywood M, Fawell S, Mackenzie IC(2005). Retention of intrinsic stem cell hierarchies in carcinoma-derived cell lines. Cancer Res vol. 65, (19) 8944-8950.

Mackenzie I (2005). Molecular strategies for the therapy of oral cancers. ORAL ONCOLOGY. vol. 1, 59-59.

Mackenzie I (2005). Stem cell patterns and differential gene expression in head and neck cancers. ORAL ONCOLOGY. vol. 1, 34-34.

Nyström ML, Thomas GJ, Stone M, Mackenzie IC, Hart IR, Marshall JF(2005). Development of a quantitative method to analyse tumour cell invasion in organotypic culture. J Pathol vol. 205, (4) 468-475.

MACKENZIE I(2005). Stem cells in oral mucosal epithelia. Oral Biosciences & Medicine vol. 2, (2) 95-103.

Tudor D, Locke M, Owen-Jones E, MACKENZIE I(2004). Intrinsic patterns of behavior of epithelial stem cells. J Invest Dermatol Symp Proc vol. 9, (3) 208-214.

Tudor D, Locke M, Owen-Jones E, Mackenzie IC (2004). Intrinsic patterns of behavior of epithelial stem cells. J Investig Dermatol Symp Proc. vol. 9, 208-214.

Hyland PL, McKeown STW, Mackenzie IC, Irwin CR(2004). Regulation of keratinocyte growth factor and scatter factor in cyclosporin-induced gingival overgrowth. J Oral Pathol Med vol. 33, (7) 391-397.

Nystrom M, Stone M, Thomas GJ, Mackenzie I, Hart IR, Marshall JF (2004). A quantitative method for measuring three-dimensional invasion in vitro using organotypic cultures. BRITISH JOURNAL OF CANCER. vol. 91, S58-S58.

Mackenzie IC(2004). Growth of malignant oral epithelial stem cells after seeding into organotypical cultures of normal mucosa. J Oral Pathol Med vol. 33, (2) 71-78.

MACKENZIE I(2004). Growth of malignant oral epithelial stem cells after seeding into organotypical cultures of normal mucosa. J.Oral Pathol.Med vol. 33, 71-78.

Locke M, Mackenzie IC (2003). Epithelial regulation by regionally defined populations of oral fibroblasts. JOURNAL OF DENTAL RESEARCH. vol. 82, 521-521.

Katsuragi H, Locke M, Mackenzie IC (2003). Fibroblast influences on connective tissue invasion by malignant human keratinocytes. JOURNAL OF DENTAL RESEARCH. vol. 82, 521-521.

Tudor D, Mackenzie IC (2003). Identification of murine epithelial stem cells in vitro. JOURNAL OF DENTAL RESEARCH. vol. 82, 520-520.

Locke M, Mackenzie IC (2003). Stem and amplifying patterns of oral tumour cells in vitro. JOURNAL OF DENTAL RESEARCH. vol. 82, 521-521.

Owen-Jones CE, Mackenzie IC (2003). The distribution of stem cell zones in human palatal epithelium. JOURNAL OF DENTAL RESEARCH. vol. 82, 521-521.

Igarashi M, Irwin CR, Locke M, Mackenzie IC(2003). Construction of large area organotypical cultures of oral mucosa and skin. J Oral Pathol Med vol. 32, (7) 422-430.

Igarashi M, Irwin M, Locke M, MACKENZIE I(2003). Construction of large area organotypical cultures or oral mucosa and skin. J Oral Path Med vol. 32, (7) 422-430.

McKeown STW, Hyland PL, Locke M, Mackenzie IC, Irwin CR(2003). Keratinocyte growth factor and scatter factor expression by regionally defined oral fibroblasts. Eur J Oral Sci vol. 111, (1) 42-50.

McKeown STW, Hyland PL, MacKenzie IC, Irwin CR (2002). KGF and SF expression by regionally defined oral fibroblasts. JOURNAL OF DENTAL RESEARCH. vol. 81, B296-B296.

McKeown S, Mackenzie IC, Irwin CR(2001). Comparison of growth factor production by regionally defined oral fibroblasts. J DENT RES vol. 80, (4) 1176-1176.

Mackenzie IC, Gao Z(2001). Keratinocyte growth factor expression in human gingival fibroblasts and stimulation of in vitro gene expression by retinoic acid. J Periodontol vol. 72, (4) 445-453.