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Publications:  Prof Rizgar Mageed

Taher TE, Bystrom J, Mignen O, Pers J-O, Renaudineau Y, Mageed RA(2020). CD5 and B lymphocyte responses: multifaceted effects through multitudes of pathways and channels. Cell Mol Immunol
10.1038/s41423-020-0490-z
Bystrom J, Clanchy FIL, Taher TE, Al-Bogami M, Ong VH, Abraham DJ, Williams RO, Mageed RA(2019). Functional and phenotypic heterogeneity of Th17 cells in health and disease. Eur J Clin Invest vol. 49, (1)
10.1111/eci.13032
https://qmro.qmul.ac.uk/xmlui/handle/123456789/49330
Garaud S, Taher TE, Debant M, Burgos M, Melayah S, Berthou C, Parikh K, Pers J-O et al.(2018). CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes. Cell Mol Immunol vol. 15, (2) 158-170.
10.1038/cmi.2016.42
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15040
Bystrom J, Clanchy FI, Taher TE, Mangat P, Jawad AS, Williams RO, Mageed RA(2018). TNFα in the regulation of Treg and Th17 cells in rheumatoid arthritis and other autoimmune inflammatory diseases. Cytokine vol. 101, 4-13.
10.1016/j.cyto.2016.09.001
https://qmro.qmul.ac.uk/xmlui/handle/123456789/37603
Taher TE, Ong VH, Bystrom J, Hillion S, Simon Q, Denton CP, Pers J-O, Abraham DJ et al.(2017). Defective regulation of autoreactive IL-6-producing transitional B lymphocytes is associated with disease in patients with systemic sclerosis. Arthritis Rheumatol
10.1002/art.40390
https://qmro.qmul.ac.uk/xmlui/handle/123456789/32152
Taher TE, Bystrom J, Ong VH, Isenberg DA, Renaudineau Y, Abraham DJ, Mageed RA(2017). Intracellular B Lymphocyte Signalling and the Regulation of Humoral Immunity and Autoimmunity. Clin Rev Allergy Immunol vol. 53, (2) 237-264.
10.1007/s12016-017-8609-4
https://qmro.qmul.ac.uk/xmlui/handle/123456789/32150
Bystrom J, Clanchy FI, Taher TE, Al-Bogami MM, Muhammad HA, Alzabin S, Mangat P, Jawad AS et al.(2017). Response to Treatment with TNFα Inhibitors in Rheumatoid Arthritis Is Associated with High Levels of GM-CSF and GM-CSF+ T Lymphocytes. Clin Rev Allergy Immunol vol. 53, (2) 265-276.
10.1007/s12016-017-8610-y
https://qmro.qmul.ac.uk/xmlui/handle/123456789/23529
Al-Bogami MM, Alkhorayef MA, Bystrom J, Akanle OA, Al-Adhoubi NK, Jawad AS, Mageed RA(2015). Favorable therapeutic response of osteoporosis patients to treatment with intravenous zoledronate compared with oral alendronate. Saudi Med J vol. 36, (11) 1305-1311.
10.15537/smj.2015.11.12731
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12185
Simon Q, Pers J-O, Cornec D, Le Pottier L, Mageed RA, Hillion S(2015). In-depth characterization of CD24highCD38high transitional human B cells reveals different regulatory profiles. Journal of Allergy and Clinical Immunology vol. 137, (5) 1577-1584.e10.
10.1016/j.jaci.2015.09.014
https://qmro.qmul.ac.uk/xmlui/handle/123456789/36374
Simon Q, Pers J-O, Cornec D, Rizgar MA, Hillion S(2015). AB0032 In-Depth Characterization of Cd24Highcd38High Transitional Human B Cells Reveals Different Regulatory Profiles and Are Abnormally Distributed in Autoimmune Diseases. Annals of the Rheumatic Diseases vol. 74, (Suppl 2) 901.1-901.
10.1136/annrheumdis-2015-eular.4446
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15722
Simon Q, Cornec D, Mageed R, Pers JO, Hillion S (2015). In-Depth Characterization of CD24(high)CD38(high) Transitional Human B Cells Reveals Different Regulatory Profiles and are Abnormally Distributed in Sjogren's Syndrome. SCANDINAVIAN JOURNAL OF IMMUNOLOGY. vol. 81, 378-378.
Hillion S, Simon Q, Cornec D, Mageed R, Pers JO (2015). IN-DEPTH CHARACTERISATION OF CD24HIGHCD38HIGH TRANSITIONAL HUMAN B CELLS REVEALS DIFFERENT REGULATORY PROFILES. ANNALS OF THE RHEUMATIC DISEASES. vol. 74, A9-A9.
10.1136/annrheumdis-2015-207259.21
Bystrom J, Taher TE, Muhyaddin MS, Clanchy FI, Mangat P, Jawad AS, Williams RO, Mageed RA(2015). Harnessing the Therapeutic Potential of Th17 Cells. Mediators Inflamm vol. 2015,
10.1155/2015/205156
https://qmro.qmul.ac.uk/xmlui/handle/123456789/10614
Bystrom J, Taher T, Al-Bogami M, Alzabin S, Kelly S, Mangat P, Williams R, Jawad A et al. (2014). CYTOKINE PRODUCTION IDENTIFIES A SUBSET OF RHEUMATOID ARTHRITIS PATIENTS T LYMPHOCYTES THAT IS ASSOCIATED WITH RESPONSIVENESS TO BIOLOGIC ANTI-TNF-ALPHA AGENTS. ANNALS OF THE RHEUMATIC DISEASES. vol. 73, 356-356.
10.1136/annrheumdis-2014-eular.4637
https://qmro.qmul.ac.uk/xmlui/handle/123456789/7630
Muhammad H, Taher T, Mullen L, Pastan I, Marshall J, Chernajovsky Y, Gould D, Mageed R (2014). Development of a novel approach for targeted delivery of siRNA to B lymphocytes with a potential application in cancer. HUMAN GENE THERAPY. vol. 25, A5-A5.
Albogami MM, Jawad AS, Mageed RA(2014). Bone loss in osteoporosis and arthritis. SAUDI MEDICAL JOURNAL vol. 35, (3) 224-233.
Albogami MM, Jawad AS, Mageed RA(2014). Bone loss in osteoporosis and arthritis. Pathogenesis and therapeutic strategies. Saudi Med J vol. 35, (3) 224-233.
Taher TE, Muhammad HA, Rahim A, Flores-Borja F, Renaudineau Y, Isenberg DA, Mageed RA(2013). Aberrant B-lymphocyte responses in lupus: inherent or induced and potential therapeutic targets. Eur J Clin Invest vol. 43, (8) 866-880.
10.1111/eci.12111
Taher TE, Muhammad HA, Bariller E, Flores-Borja F, Renaudineau Y, Isenberg DA, Mageed RA(2013). B-lymphocyte signalling abnormalities and lupus immunopathology. Int Rev Immunol vol. 32, (4) 428-444.
10.3109/08830185.2013.788648
Muhammad H, Taher T, Mullen L, Pastan I, Chernajovsky Y, Gould D, Mageed R (2013). Generation of a secreted scFv for specific delivery of siRNA to B-lymphocytes. HUMAN GENE THERAPY. vol. 24, A36-A36.
Bystrom J, Al-Adhoubi N, Al-Bogami M, Jawad AS, Mageed RA(2013). Th17 lymphocytes in respiratory syncytial virus infection. Viruses vol. 5, (3) 777-791.
10.3390/v5030777
https://qmro.qmul.ac.uk/xmlui/handle/123456789/13837
Alzabin S, Abraham SM, Taher TE, Palfreeman A, Hull D, McNamee K, Jawad A, Pathan E et al.(2012). Incomplete response of inflammatory arthritis to TNF alpha blockade is associated with the Th17 pathway. ANNALS OF THE RHEUMATIC DISEASES vol. 71, (10) 1741-1748.
10.1136/annrheumdis-2011-201024
Alzabin S, Abraham SM, Taher TE, Palfreeman A, Hull D, McNamee K, Jawad A, Pathan E et al.(2012). Incomplete response of inflammatory arthritis to TNFα blockade is associated with the Th17 pathway. Ann Rheum Dis vol. 71, (10) 1741-1748.
10.1136/annrheumdis-2011-201024
Thabet Y, Cañas F, Ghedira I, Youinou P, Mageed RA, Renaudineau Y(2012). Altered patterns of epigenetic changes in systemic lupus erythematosus and auto-antibody production: is there a link?. J Autoimmun vol. 39, (3) 154-160.
10.1016/j.jaut.2012.05.015
Mageed RA, Garaud S, Taher TE, Parikh K, Pers J-O, Jamin C, Renaudineau Y, Youinou P(2012). CD5 expression promotes multiple intracellular signaling pathways in B lymphocyte. Autoimmun Rev vol. 11, (11) 795-798.
10.1016/j.autrev.2012.02.007
Nordin NI, D'acquisto F, Gibbons S, Perrett D, Mageed RA (2011). Potent anti-inflammatory compounds identified in Zingiber officinale Roscoe var. rubrum Theilade: Mechanisms of action in psoriasis. PLANTA MEDICA. vol. 77, 1422-1423.
Garaud S, Morva A, Lemoine S, Hillion S, Bordron A, Pers J-O, Berthou C, Mageed RA et al.(2011). CD5 promotes IL-10 production in chronic lymphocytic leukemia B cells through STAT3 and NFAT2 activation. J Immunol vol. 186, (8) 4835-4844.
10.4049/jimmunol.1003050
Mittal GA, Mageed RA, Chernajovsky Y (2011). HUMAN (H161R) IL-17F MUTANT IS A DUAL ANTAGONIST OF IL-17A AND IL-17F. RHEUMATOLOGY. vol. 50, 53-53.
Nordin NI, D'Acquisto F, Gibbons S, Perrett D, Mageed RA (2010). Immune-modulatory effects of compounds isolated from Zingiber officinale Roscoe (var. rubrum Theilade) on immune mechanisms associated with psoriasis. IMMUNOLOGY. vol. 131, 65-65.
Séïté J-F, Cornec D, Renaudineau Y, Youinou P, Mageed RA, Hillion S(2010). IVIg modulates BCR signaling through CD22 and promotes apoptosis in mature human B lymphocytes. Blood vol. 116, (10) 1698-1704.
10.1182/blood-2009-12-261461
Taher TE, Parikh K, Flores-Borja F, Mletzko S, Isenberg DA, Peppelenbosch MP, Mageed RA(2010). Protein phosphorylation and kinome profiling reveal altered regulation of multiple signaling pathways in B lymphocytes from patients with systemic lupus erythematosus. Arthritis Rheum vol. 62, (8) 2412-2423.
10.1002/art.27505
Garaud S, Le Dantec C, de Mendoza AR, Mageed RA, Youinou P, Renaudineau Y(2009). IL-10 production by B cells expressing CD5 with the alternative exon 1B. Ann N Y Acad Sci vol. 1173, 280-285.
10.1111/j.1749-6632.2009.04616.x
Alard J-E, Dueymes M, Mageed RA, Saraux A, Youinou P, Jamin C(2009). Mitochondrial heat shock protein (HSP) 70 synergizes with HSP60 in transducing endothelial cell apoptosis induced by anti-HSP60 autoantibody. FASEB J vol. 23, (8) 2772-2779.
10.1096/fj.08-128785
Youinou P, Taher TE, Pers J-O, Mageed RA, Renaudineau Y(2009). B lymphocyte cytokines and rheumatic autoimmune disease. Arthritis Rheum vol. 60, (7) 1873-1880.
10.1002/art.24665
Garaud S, Le Dantec C, Jousse-Joulin S, Hanrotel-Saliou C, Saraux A, Mageed RA, Youinou P, Renaudineau Y(2009). IL-6 modulates CD5 expression in B cells from patients with lupus by regulating DNA methylation. J Immunol vol. 182, (9) 5623-5632.
10.4049/jimmunol.0802412
Rochas C, Hillion S, Saraux A, Mageed RA, Youinou P, Jamin C, Devauchelle V(2009). Transmembrane BAFF from rheumatoid synoviocytes requires interleukin-6 to induce the expression of recombination-activating gene in B lymphocytes. Arthritis Rheum vol. 60, (5) 1261-1271.
10.1002/art.24498
Mageed RA, Mletzko S, Varin M, Duchene J, Taher T, Warnes G, Jawad AS, Isenberg DA (2009). ALTERED MEMBRANE CD45 ISOFORM EXPRESSION AND INTRACELLULAR SIGNALLING DEFECTS IN B CELLS FROM PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS(SLE). RHEUMATOLOGY. vol. 48, I32-I32.
Jawad AS, Taher TE, Rahim A, D'Acquisto F, Gould D, Mageed RA (2009). SELECTIVE TARGETING OF THE CANONICAL OR ALTERNATIVE NF-kappa B PATHWAY REVEALS NEW INSIGHTS INTO MECHANISMS OF B-LYMPHOCYTE SURVIVAL AND SELECTION. RHEUMATOLOGY. vol. 48, I30-I31.
Habib HM, Taher TE, Isenberg DA, Mageed RA(2009). Enhanced propensity of T lymphocytes in patients with systemic lupus erythematosus to apoptosis in the presence of tumour necrosis factor alpha. Scand J Rheumatol vol. 38, (2) 112-120.
10.1080/03009740802409496
Mletzko S, Varin MM, Duchene J, Taher T, Warnes G, Isenberg DA, Mageed RA (2008). Altered membrane expression levels of distinct CD45RB isoforms are associated with B cell hyperactivity in systemic lupus erythematosus (SLE). IMMUNOLOGY. vol. 125, 41-41.
Taher TE, Tulone C, Fatah R, D'Acquisto F, Gould DJ, Mageed RA(2008). Repopulation of B-lymphocytes with restricted gene expression using haematopoietic stem cells engineered with lentiviral vectors. Gene Ther vol. 15, (13) 998-1006.
10.1038/gt.2008.33
Jawad AS, Mangat P, Perry D, Mageed RA (2008). Anti-TNF alpha-based therapy in rheumatoid arthritis (RA): Mechanisms of action and possible causes of non-responsiveness. RHEUMATOLOGY. vol. 47, II37-II38.
Zouali M, Mageed RA(2008). Cellular interactions and signalling defects in lupus(1). LUPUS vol. 17, (3) 236-240.
10.1177/0961203307088247
Flores-Borja F, Kabouridis PS, Jury EC, Isenberg DA, Mageed RA(2007). Altered lipid raft-associated proximal signaling and translocation of CD45 tyrosine phosphatase in B lymphocytes from patients with systemic lupus erythematosus. Arthritis Rheum vol. 56, (1) 291-302.
10.1002/art.22309
Flores-Borja F, Kabouridis PS, Jury EC, Isenberg DA, Mageed RA(2006). Lyn dericiency in B cells from patients with systemic lupus erythematosus: comment on the article by Flores-Borja et al - Reply. ARTHRITIS RHEUM vol. 54, (6) 2037-2038.
10.1002/art.21877
Flores-Borja F, Kabouridis PS, Jury EC, Isenberg DA, Mageed RA(2005). Decreased Lyn expression and translocation to lipid raft signaling domains in B lymphocytes from patients with systemic lupus erythematosus. Arthritis Rheum vol. 52, (12) 3955-3965.
10.1002/art.21416
Renaudineau Y, Hillion S, Saraux A, Mageed RA, Youinou P(2005). An alternative exon 1 of the CD5 gene regulates CD5 expression in human B lymphocytes. BLOOD vol. 106, (8) 2781-2789.
10.1182/blood-2005-02-0597
Flores-Borja F, Kabouridis PS, Jury E, Isenberg D, Mageed RA (2005). Translocation of CD45 to lipid raft signalling domains and abnormal relocation during B-lymphocyte activation in SLE. RHEUMATOLOGY. vol. 44, I17-I17.
Jury EC, Kabouridis PS, Flores-Borja F, Mageed RA, Isenberg DA (2004). ALTERED LIPID RAFT EXPRESSION AND ASSOCIATED SIGNALLING IN T LYMPHOCYTES FROM PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS (SLE). RHEUMATOLOGY. vol. 43, 24-24.
Flores-Borja F, Kabouridis PS, Jury E, Isenberg D, Mageed RA (2004). ATYPICAL CO-LOCALISATION OF CD45 AND LYN TO LIPID RAFT SIGNALLING DOMAINS CORRELATES WITH B-LYMPHOCYTE HYPER RESPONSIVENESS IN PATIENTS WITH LUPUS. RHEUMATOLOGY. vol. 43, 108-108.
Kabouridis PS, MAGEED R, Flores-Borja F, Isenberg DA, Jury EC(2004). Altered lipid raft-associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus. Journal of Clinical Investigation vol. 113, (8) 1176-1187.
10.1172/JCI200420345
Jury EC, Kabouridis PS, Flores-Borja F, Mageed RA, Isenberg DA(2004). Altered lipid raft-associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus. J Clin Invest vol. 113, (8) 1176-1187.
10.1172/JCI20345
Mackworth-Young CG, Harmer IJ, Mageed RA(2003). The role of antigen in the selection of the human V3-23 immunoglobulin heavy chain variable region gene. Clin Exp Immunol vol. 134, (3) 420-425.
10.1111/j.1365-2249.2003.02319.x
Jury EC, Kabouridis PS, Flores-Borja F, Mageed RA, Isenberg DA (2003). Abnormal co-localisation of CD45 and lipid rafts is associated with reduced LCK expression in T cells from patients with SLE. ARTHRITIS AND RHEUMATISM. vol. 48, S193-S193.
Mageed RA, Prud'homme GJ(2003). Immunopathology and the gene therapy of lupus. GENE THER vol. 10, (10) 861-874.
10.1038/sj.gt.3302016
Jury EC, Kabouridis PS, Abba A, Mageed RA, Isenberg DA(2003). Increased ubiquitination and reduced expression of LCK in T lymphocytes from patients with systemic lupus erythematosus. ARTHRITIS RHEUM vol. 48, (5) 1343-1354.
10.1002/art.10978
Flores-Borja F, Kabouridis PS, Jury E, Isenberg D, Mageed RA (2003). ANALYSIS OF LIPID RAFT-ASSOCIATED SIGNALLING MOLECULES IN B CELLS FROM NORMAL AND PATIENTS WITH SLE. RHEUMATOLOGY. vol. 42, 72-73.
Jury EC, Kabouridis PS, Flores-Borja F, Mageed RA, Isenberg DA (2003). CD45 IS ABNORMALLY ASSOCIATED WITH LIPID RAFTS IN T LYMPHOCYTES FROM PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS (SLE). RHEUMATOLOGY. vol. 42, 5-5.
Williams RO, Ahmed S, Isenberg DA, Mageed RA(2003). DEFICIENCY IN A-KINASE ANCHOR PROTEIN EXPRESSION IN PERIPHERAL BLOOD LEUKOCYTES FROM PATIENTS WITH SLE. RHEUMATOLOGY vol. 42, 73-73.
MAGEED R, Lydyard PM, Youinou P(2002). B cells underpin lupus immunopathology. Lupus vol. 11, (1) 1-3.
Mageed RA, Zack DJ (2002). Cross-reactivity and pathogenicity of anti-DNA autoantibodies in systemic lupus erythematosus. LUPUS. vol. 11, 783-786.
10.1191/0961203302lu317oa
MAGEED R, Zack DJ(2002). Cross-reactivity and pathogenicity of anti-DNA autoantibodies in systemic lupus erythematosus. Lupus vol. 11, 783-786.
MAGEED R, Ruzickova S, Zd'arsky E, Vencovsky J, Moyes SP, Hajeer A, Ollier WE, Maini RN et al.(2002). Polymorphism in the immunoglobulin VH gene V1-69 affects susceptibility to rheumatoid arthritis in subjects lacking the HLA-DRB1 shared epitope. Rheumatology vol. 41, 401-410.
Mageed RA, Isenberg DA(2002). Tumour necrosis factor alpha in systemic lupus erythematosus and anti-DNA autoantibody production. LUPUS vol. 11, (12) 850-855.
10.1191/096120332lu306rr
MAGEED R, Jarosova K, Ozen S, Nemcova D, Niederlova J, Ruzickova S, Ollier W, Vencovsky J(2001). Higher Frequency of Allele 2 of the Interleukin-1 Receptor Antagonist Gene in Patients With Juvenile Idiopathic Arthritis. Arthritis and Rheumatism vol. 44, (10) 2387-2391.
10.1002/1529-0131(200110)44:10<2387::AID-ART403>3.0.CO;2-7
MAGEED R, Mackworth-Young CG, Maziak BB, Wynn SL, Harmer IJ, Moyes SP, Bruggemann M(2001). Rearrangement of the human heavy chain variable region gene V3-23 in transgenic mice generates antibodies reactive with a range of antigens on the basis of VHCDR3 and residues intrinsic to the heavy chain variable region. Clin Exp Immunol vol. 123, 1-8.
MAGEED R, Renaudineau Y, Pers JO, Kulikova N, Jamin C, Porakishvili N, Youinou P, Lydyard PM(2001). Recent progress in the understanding of B-cell functions in autoimmunity. Scand J Immunol. vol. 54, 30-38.
MAGEED R, Mackworth-Young CG, Mason AN(2001). The effects of a human IgM monoclonal anticardiolipin antibody on pregnancy in a transgenic mouse model. Lupus vol. 10, 289-294.
MAGEED R(1994). The RF antigen. Manual of Biological Markers of Disease, Editors: Venrooij, WJV, Maini, RN, vol. 1, Kluwer Academic Publishers
MAGEED R, Venables PJ, Baboonian C, Horsfall AC, Halliday D, Maini RN, Teo CG, Millman G(1989). The response of Epstein-Barr virus infection in Sjogren's syndrome. Sjogren's syndrome a model for understanding autoimmunity, Editors: Talal, N, Academic Press Ltd
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