Publications: Dr Stephanie Kermorgant

Fernandes M, Hoggard B, Jamme P, Paget S, Truong M, Grégoire V, Vinchent A, Descarpentries C et al. ( 2023 ) . MET exon 14 skipping mutation is a hepatocyte growth factor (HGF)‐dependent oncogenic driver in vitro and in humanised HGF knock‐in mice . Molecular Oncology vol. 17 , ( 11 ) 2257 - 2274 .

Kermorgant S ( 2023 ) . Rationale for Cotargeting Hepatocyte Growth Factor and Epidermal Growth Factor Receptor in Recurrent/Metastatic Head and Neck Cancer . Journal of Clinical Oncology vol. 41 , ( 22 ) 3863 - 3866 .

Stanislovas J, Kermorgant S ( 2022 ) . c-Met-integrin cooperation: Mechanisms, tumorigenic effects, and therapeutic relevance . Frontiers in Cell and Developmental Biology vol. 10 ,

Wood GE, Hockings H, Hilton DM, Kermorgant S ( 2021 ) . The role of MET in chemotherapy resistance . Oncogene vol. 40 , ( 11 ) 1927 - 1941 .

Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH et al. ( 2021 ) . Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)¹ . Autophagy vol. 17 , ( 1 ) 1 - 382 .

Noval A, Fletcher K, Florey O, Kermorgant S ( 2020 ) . The interplay between Met and autophagy in PDAC . Pancreatology vol. 20 , ( 8 )

Hervieu A, Kermorgant S ( 2020 ) . Unconventional role of RAC1 in MET-driven anchorage-independent tumor growth . Molecular & Cellular Oncology vol. 7 , ( 6 )

Hervieu A, Heuss SF, Zhang C, Barrow-McGee R, Joffre C, Ménard L, Clarke PA, Kermorgant S ( 2020 ) . A PI3K- and GTPase-independent Rac1-mTOR mechanism mediates MET-driven anchorage-independent cell growth but not migration . Science Signaling vol. 13 , ( 637 )

Wood GE, Lockley M, Kermorgant S ( 2019 ) . 68P C-met mediates invasion and chemotherapy resistance in high grade serous ovarian cancer . Annals of Oncology . vol. 30 ,

Hervieu A, Kermorgant S ( 2018 ) . The Role of PI3K in Met Driven Cancer: A Recap . Frontiers in Molecular Biosciences vol. 5 ,

Wood GE, Heuss SF, Osagie I, Lockley M, Kermorgant S ( 2018 ) . c-Met signalling and endocytosis in clear cell ovarian cancer . INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER . vol. 28 , 95 - 95 .

Badreldin W, Powles T, Menard L, Ho-Yen C, Kermorgant S ( 2017 ) . 60P Understanding and targeting Met signalling in bladder cancer . Annals of Oncology vol. 28 ,

Badreldin W, Powles T, Menard L, Ho-Yen C, Kermorgant S ( 2017 ) . Understanding and targeting Met signalling in bladder cancer . ANNALS OF ONCOLOGY . vol. 28 ,

Barrow-McGee R, Kishi N, Joffre C, Ménard L, Hervieu A, Bakhouche BA, Noval AJ, Mai A et al. ( 2016 ) . Corrigendum: Beta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes . Nat Commun vol. 7 , 12392 - 12392 .

Barrow-McGee R, Kishi N, Joffre C, Ménard L, Hervieu A, Bakhouche BA, Noval AJ, Mai A et al. ( 2016 ) . Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes . Nature Communications vol. 7 , 11942 - 11942 .

Mofta H, Dias K, Hoque Apu E, Liu L, Uttagomal J, Bergmeier L, Kermorgan S, Wan H ( 2016 ) . Desmoglein 3 regulates membrane trafficking of cadherins, an implication in cell-cell adhesion . Cell Adhesion & Migration

Hervieu A, Kermorgant S ( 2015 ) . Abstract B26: PI3K class I and mTOR regulate distinct steps in Met dependent tumorigenesis . Molecular Cancer Therapeutics vol. 14 , ( 7_Supplement ) b26 - b26 .

Ho-Yen CM, Jones JL, Kermorgant S ( 2015 ) . The clinical and functional significance of c-Met in breast cancer: a review . Breast Cancer Research vol. 17 , ( 1 )

Hervieu A, Joffre C, Leung Z, Kermorgant S ( 2014 ) . 476: Understanding and targeting PI3K pathway downstream of Met oncogenic mutant . European Journal of Cancer vol. 50 ,

Ménard L, Parker PJ, Kermorgant S ( 2014 ) . Receptor tyrosine kinase c-Met controls the cytoskeleton from different endosomes via different pathways . Nat Commun vol. 5 ,

Mai A, Muharram G, Barrow-McGee R, Baghirov H, Rantala J, Kermorgant S, Ivaska J ( 2014 ) . Distinct c-Met activation mechanisms induce cell rounding or invasion through pathways involving integrins, RhoA and HIP1 . J Cell Sci vol. 127 , ( Pt 9 ) 1938 - 1952 .

Barrow-McGee R, Kermorgant S ( 2014 ) . Met endosomal signalling: in the right place, at the right time . Int J Biochem Cell Biol vol. 49 , 69 - 74 .

Ho-Yen CM, Green AR, Rakha EA, Brentnall AR, Ellis IO, Kermorgant S, Jones JL ( 2014 ) . C-Met in invasive breast cancer: is there a relationship with the basal-like subtype? . Cancer vol. 120 , ( 2 ) 163 - 171 .

Barrow R, Joffre C, Ménard L, Kermorgant S ( 2014 ) . Measuring the role for Met endosomal signaling in tumorigenesis . Methods Enzymol vol. 535 , 121 - 140 .

Barrow-McGee R, Kermorgant S ( 2014 ) . Met endosomal signalling: In the right place, at the right time . INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY vol. 49 , 69 - 74 .

Moftah H, Diaz K, Kermorgant S, Wan H ( 2014 ) . Role for Desmoglein 3 in regulating E-cadherin trafficking . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 134 , S29 - S29 .

Radtke S, Milanovic M, Rossé C, De Rycker M, Lachmann S, Hibbert A, Kermorgant S, Parker PJ ( 2013 ) . ERK2 but not ERK1 mediates HGF-induced motility in non-small cell lung carcinoma cell lines . J Cell Sci vol. 126 , ( Pt 11 ) 2381 - 2391 .

Ho-Yen C, Bowen RL, Kermorgant S, Jones JL ( 2013 ) . Comment on 'High MET expression is an adverse prognostic factor in patients with triple-negative breast cancer' . Br J Cancer vol. 108 , ( 10 ) 2195 - 2196 .

Joffre C, Barrow R, Ménard L, Kermorgant S ( 2013 ) . RTKs as Models for Trafficking Regulation: c-Met/HGF Receptor-c-Met Signalling in Cancer—Location Counts . Vesicle Trafficking in Cancer , Springer Nature

Milanovic M, Radtke S, Peel N, Howell M, Carrière V, Joffre C, Kermorgant S, Parker PJ ( 2012 ) . Anomalous inhibition of c-Met by the kinesin inhibitor aurintricarboxylic acid . Int J Cancer vol. 130 , ( 5 ) 1060 - 1070 .

Ho-Yen C, Green A, Ellis I, Kermorgant S, Jones LJ ( 2012 ) . C-Met Expression Correlates with Molecular Sub-type and Outcome in Invasive Breast Cancer . JOURNAL OF PATHOLOGY . vol. 228 , S16 - S16 .

Bowen RL, Ho-Yen C, Vaziri R, Hulit J, Ryan D, Ornstein M, White Y, Choy C et al. ( 2011 ) . C-met Defines a Distinct Subset of Triple Negative Breast Cancer in British Black Women . JOURNAL OF PATHOLOGY . vol. 224 , S21 - S21 .

Joffre C, Barrow R, Ménard L, Calleja V, Hart IR, Kermorgant S ( 2011 ) . A direct role for Met endocytosis in tumorigenesis . Nat Cell Biol vol. 13 , ( 7 ) 827 - 837 .

Reynolds LE, Watson AR, Baker M, Jones TA, D'Amico G, Robinson SD, Joffre C, Garrido-Urbani S et al. ( 2010 ) . Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome (vol 465, pg 813, 2010) . NATURE vol. 466 , ( 7304 )

Reynolds LE, Watson AR, Baker M, Jones TA, D'Amico G, Robinson SD, Joffre C, Garrido-Urbani S et al. ( 2010 ) . Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome . Nature vol. 465 , ( 7299 ) 813 - 817 .

Kermorgant S, Nevo J, Ivaska J ( 2010 ) . Smart targeting of EGFR in lung cancer . PHARMACOGENOMICS vol. 11 , ( 6 ) 743 - 744 .

Barrow R, Menard L, Kermorgant S ( 2010 ) . c-Met endosomal signalling and breast cancer cell migration . EJC SUPPLEMENTS . vol. 8 , 116 - 116 .

Rosse C, Linch M, Kermorgant S, Cameron AJM, Boeckeler K, Parker PJ ( 2010 ) . PKC and the control of localized signal dynamics . Nat Rev Mol Cell Biol vol. 11 , ( 2 ) 103 - 112 .

Hormi K, Cadiot G, Kermorgant S, Dessirier V, Le Romancer M, Lewin MJM, Mignon M, Lehy T ( 2009 ) . Transforming Growth Factor-α and Epidermal Growth Factor Receptor in Colonic Mucosa in Active and Inactive Inflammatory Bowel Disease . Growth Factors vol. 18 , ( 2 ) 79 - 91 .

Kermorgant S, Parker PJ ( 2008 ) . Receptor trafficking controls weak signal delivery: a strategy used by c-Met for STAT3 nuclear accumulation . J Cell Biol vol. 182 , ( 5 ) 855 - 863 .

Aparicio T, Kermorgant S, Darmoul D, Guilmeau S, Hormi K, Mahieu-Caputo D, Lehy T ( 2005 ) . Leptin and Ob-Rb receptor isoform in the human digestive tract during fetal development . J CLIN ENDOCR METAB vol. 90 , ( 11 ) 6177 - 6184 .

Kermorgant S, Parker PJ ( 2005 ) . c-met signalling - Spatio-temporal decisions . CELL CYCLE vol. 4 , ( 3 ) 352 - 355 .

Kermorgant S, Zicha D, Parker PJ ( 2004 ) . PKC controls HGF-dependent c-Met traffic, signalling and cell migration . EMBO J vol. 23 , ( 19 ) 3721 - 3734 .

Casamassima A, Durgan J, Iturrioz X, Jevons A, Kermorgant S, Saurin A, Sipeki S, Parker P ( 2004 ) . PKC superfamily - localised action and complex assembly . FASEB JOURNAL . vol. 18 , C122 - C122 .

Kermorgant S, Zicha D, Parker PJ ( 2003 ) . Protein kinase C controls microtubule-based traffic but not proteasomal degradation of c-Met . J Biol Chem vol. 278 , ( 31 ) 28921 - 28929 .

Ivaska J, Kermorgant S, Whelan R, Parsons M, Ng T, Parker PJ ( 2003 ) . Integrin-protein kinase C relationships . Biochem Soc Trans vol. 31 , ( Pt 1 ) 90 - 93 .

Walker F, Kermorgant S, Daraï E, Madelenat P, Cremieux AC, Hénin D, Lehy T ( 2003 ) . Hepatocyte growth factor and c-Met in cervical intraepithelial neoplasia: overexpression of proteins associated with oncogenic human papillomavirus and human immunodeficiency virus . Clin Cancer Res vol. 9 , ( 1 ) 273 - 284 .

Kermorgant S, Dessirier V, Lewin MJM, Lehy T ( 2002 ) . Erratum: HGF upregulates and modifies subcellular distribution of proteins in colon cancer cell enterocytic differentiation (American Journal of Physiology - Gastrointestinal and Liver Physiology (October 2001) 281 (G1068-G1080)) . American Journal of Physiology - Gastrointestinal and Liver Physiology vol. 282 , ( 3 45-3 )

Kermorgant S, Dessirier V, Lewin MJM, Lehy T ( 2002 ) . HGF upregulates and modifies subcellular distribution of proteins in colon cancer cell enterocytic differentiation (vol 281, pg G1068, 2001) . AM J PHYSIOL-GASTR L vol. 282 , ( 3 ) GA2 - GA2 .

Goïot H, Attoub S, Kermorgant S, Laigneau JP, Lardeux B, Lehy T, Lewin MJ, Bado A ( 2001 ) . Antral mucosa expresses functional leptin receptors coupled to STAT-3 signaling, which is involved in the control of gastric secretions in the rat . Gastroenterology vol. 121 , ( 6 ) 1417 - 1427 .

Kermorgant S, Dessirier V, Lewin MJ, Lehy T ( 2001 ) . HGF upregulates and modifies subcellular distribution of proteins in colon cancer cell enterocytic differentiation . Am J Physiol Gastrointest Liver Physiol vol. 281 , ( 4 ) G1068 - G1080 .

Kermorgant S, Lehy T ( 2001 ) . Glycine-extended gastrin promotes the invasiveness of human colon cancer cells . BIOCHEM BIOPH RES CO vol. 285 , ( 1 ) 136 - 141 .

Kermorgant S, Aparicio T, Dessirier V, Lewin MJ, Lehy T ( 2001 ) . Hepatocyte growth factor induces colonic cancer cell invasiveness via enhanced motility and protease overproduction. Evidence for PI3 kinase and PKC involvement . Carcinogenesis vol. 22 , ( 7 ) 1035 - 1042 .

Sobhani I, Bado A, Vissuzaine C, Buyse M, Kermorgant S, Laigneau JP, Attoub S, Lehy T et al. ( 2000 ) . Leptin secretion and leptin receptor in the human stomach . Gut vol. 47 , ( 2 )

Aparicio T, Kermorgant S, Dessirier V, Lewin MJM, Lehy T ( 1999 ) . Matrix metalloproteinase inhibition prevents colon cancer peritoneal carcinomatosis development and prolongs survival in rats . Carcinogenesis vol. 20 , ( 8 ) 1445 - 1452 .

Bado A, Levassent S, Attoub Samir S, Kermorgant S, Laigneau JP, Moizo L, Lehy T, Lewin MJM ( 1998 ) . Leptin : A new gastric hormone . Zeitschrift fur Gastroenterologie vol. 36 , ( 12 )

Bado A, Levasseur S, Attoub S, Kermorgant S, Laigneau J-P, Bortoluzzi M-N, Moizo L, Lehy T et al. ( 1998 ) . The stomach is a source of leptin . Nature vol. 394 , ( 6695 ) 790 - 793 .

Aparicio T, Kermorgant S, Lewin MJ, Lehy T ( 1998 ) . Effects of HGF on the production of matrix metalloproteinases by colonic cancer cells DHD/K12 . Biologie Aujourd hui vol. 192 , ( 2 ) 311 - 315 .

Kermorgant S, Walker F, Hormi K, Dessirier V, Lewin M, Lehy T ( 1997 ) . Developmental expression and functionality of hepatocyte growth factor and c-Met in human fetal digestive tissues . Gastroenterology vol. 112 , ( 5 ) 1635 - 1647 .

Kermorgant S, Cadiot G, Lewin MJ, Lehy T ( 1996 ) . Expression of hepatocyte growth factor and its receptor, C-Met in human digestive tissues and different gastric and colonic cancer cell lines . Clinics and Research in Hepatology and Gastroenterology vol. 20 , ( 5 ) 438 - 445 .