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Publications:  Dr Peter King

Novoselova TV, King PJ, Guasti L, Metherell LA, Clark AJL, Chan LF(2019). ACTH signalling and adrenal development: Lessons from mouse models. Endocrine Connections vol. 8, (7) R122-R130.
10.1530/EC-19-0190
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59205
Hadjidemetriou I, Mariniello K, Ruiz-Babot G, Pittaway J, Mancini A, Mariannis D, Gomez-Sanchez CE, Parvanta L et al.(2019). DLK1/PREF1 marks a novel cell population in the human adrenal cortex. The Journal of Steroid Biochemistry and Molecular Biology vol. 193,
10.1016/j.jsbmb.2019.105422
https://qmro.qmul.ac.uk/xmlui/handle/123456789/61875
O¿Toole SM, Watson DS, Novoselova TV, Romano LEL, King PJ, Bradshaw TY, Thompson CL, Knight MM et al.(2019). Oncometabolite induced primary cilia loss in pheochromocytoma. Endocrine-Related Cancer vol. 26, (1) 165-180.
10.1530/ERC-18-0134
https://qmro.qmul.ac.uk/xmlui/handle/123456789/44923
Novoselova TV, Hussain M, King PJ, Guasti L, Metherell LA, Charalambous M, Clark AJL, Chan LF(2018). MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation. FASEB Journal vol. 32, (11) 6186-6196.
10.1096/fj.201701274RR
https://qmro.qmul.ac.uk/xmlui/handle/123456789/39467
Read JE, Cabrera-Sharp V, Kitscha P, Cartwright JE, King PJ, Fowkes RC, de Mestre AM(2018). Glial Cells Missing 1 Regulates Equine Chorionic Gonadotrophin Beta Subunit via Binding to the Proximal Promoter. Frontiers in Endocrinology vol. 9, 195-195.
10.3389/fendo.2018.00195
Johnston ZC, Bellingham M, Filis P, Soffientini U, Hough D, Bhattacharya S, Simard M, Hammond GL et al.(2018). The human fetal adrenal produces cortisol but no detectable aldosterone throughout the second trimester. BMC Med vol. 16, (1) 23-23.
10.1186/s12916-018-1009-7
Ruiz-Babot G, Balyura M, Hadjidemetriou I, Ajodha SJ, Taylor DR, Ghataore L, Taylor NF, Schubert U et al.(2018). Modeling Congenital Adrenal Hyperplasia and Testing Interventions for Adrenal Insufficiency Using Donor-Specific Reprogrammed Cells. Cell Reports vol. 22, (5) 1236-1249.
10.1016/j.celrep.2018.01.003
https://qmro.qmul.ac.uk/xmlui/handle/123456789/32031
Katugampola H, King PJ, Chatterjee S, Meso M, Duncan AJ, Achermann JC, Guasti L, Ghataore L et al.(2017). Kisspeptin is a novel regulator of human fetal adrenocortical development and function – a finding with important implications for the human feto-placental unit. The Journal of Clinical Endocrinology & Metabolism
10.1210/jc.2017-00763
https://qmro.qmul.ac.uk/xmlui/handle/123456789/25680
Hawkins KE, Joy S, Delhove JMKM, Kotiadis VN, Fernandez E, Fitzpatrick LM, Whiteford JR, King PJ et al.(2016). NRF2 Orchestrates the Metabolic Shift during Induced Pluripotent Stem Cell Reprogramming. Cell Reports vol. 14, (8) 1883-1891.
10.1016/j.celrep.2016.02.003
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12358
Diaz-Cano S, Szyszka P, Weitsman G, Dudka D, King P, Korbonits M, Grossman A, Schulte K-M et al. (2015). Effect of Erlotinib on Proliferation and Steriodogenesis in Primary Cultures of Adrenocortical Carcinoma. LABORATORY INVESTIGATION. vol. 95, 133A-133A.
Ruiz-Babot G, Hadjidemetriou I, King PJ, Guasti L(2015). New directions for the treatment of adrenal insufficiency. Frontiers in Endocrinology vol. 6, (MAY)
10.3389/fendo.2015.00070
https://qmro.qmul.ac.uk/xmlui/handle/123456789/9770
Dworakowska D, Dudka D, Weitsman G, King PJ, Diaz-Cano SJ, Korbonits M, Grossman AB, Aylwin SJB et al.(2014). Simultaneous Targeting PI3K/Akt/mTOR and MEK/RAF/ERK Pathways Results in a Synergistic Anti-Proliferative Effect in an Adrenocortical Carcinoma Model. ENDOCRINE REVIEWS vol. 35, (3)
Guasti L, Cavlan D, Cogger K, Banu Z, Shakur A, Latif S, King PJ(2013). Dlk1 up-regulates Gli1 expression in male rat adrenal capsule cells through the activation of β1 integrin and ERK1/2. Endocrinology vol. 154, (12) 4675-4684.
10.1210/en.2013-1211
Guasti L, Candy Sze WC, McKay T, Grose R, King PJ(2013). FGF signalling through Fgfr2 isoform IIIb regulates adrenal cortex development. Molecular and Cellular Endocrinology vol. 371, (1-2) 182-188.
10.1016/j.mce.2013.01.014
Guasti L, Candy Sze WC, McKay T, Grose R, King PJ(2013). FGF signalling through Fgfr2 isoform IIIb regulates adrenal cortex development. Mol Cell Endocrinol vol. 371, (1-2) 182-188.
10.1016/j.mce.2013.01.014
Meimaridou E, Hughes CR, Kowalczyk J, Guasti L, Chapple JP, King PJ, Chan LF, Clark AJL et al.(2013). Familial glucocorticoid deficiency: New genes and mechanisms. Molecular and Cellular Endocrinology vol. 371, (1-2) 195-200.
10.1016/j.mce.2012.12.010
Meimaridou E, Hughes CR, Kowalczyk J, Guasti L, Chapple JP, King PJ, Chan LF, Clark AJL et al.(2013). Familial glucocorticoid deficiency: New genes and mechanisms. Mol Cell Endocrinol vol. 371, (1-2) 195-200.
10.1016/j.mce.2012.12.010
Yates R, Katugampola H, Cavlan D, Cogger K, Meimaridou E, Hughes C, Metherell L, Guasti L et al.(2013). Adrenocortical development, maintenance, and disease. Curr Top Dev Biol vol. 106, 239-312.
10.1016/B978-0-12-416021-7.00007-9
Marion V, Mockel A, De Melo C, Obringer C, Claussmann A, Simon A, Messaddeq N, Durand M et al.(2012). BBS-Induced Ciliary Defect Enhances Adipogenesis, Causing Paradoxical Higher-Insulin Sensitivity, Glucose Usage, and Decreased Inflammatory Response. CELL METABOLISM vol. 16, (3) 363-377.
10.1016/j.cmet.2012.08.005
Thompson IR, Chand AN, King PJ, Ansorge O, Karavitaki N, Jones CA, Rahmutula D, Gardner DG et al.(2012). Expression of guanylyl cyclase-B (GC-B/NPR2) receptors in normal human fetal pituitaries and human pituitary adenomas implicates a role for C-type natriuretic peptide. Endocr Relat Cancer vol. 19, (4) 497-508.
10.1530/ERC-12-0129
Meimaridou E, Kowalczyk J, Guasti L, Hughes CR, Wagner F, Frommolt P, Nürnberg P, Mann NP et al.(2012). Mutations in NNT encoding nicotinamide nucleotide transhydrogenase cause familial glucocorticoid deficiency. Nat Genet vol. 44, (7) 740-742.
10.1038/ng.2299
https://qmro.qmul.ac.uk/xmlui/handle/123456789/18037
Laufer E, Kesper D, Vortkamp A, King P(2012). Sonic hedgehog signaling during adrenal development. MOLECULAR AND CELLULAR ENDOCRINOLOGY vol. 351, (1) 19-27.
10.1016/j.mce.2011.10.002
Hughes CR, Guasti L, Meimaridou E, Chuang C-H, Schimenti JC, King PJ, Costigan C, Clark AJL et al.(2012). MCM4 mutation causes adrenal failure, short stature, and natural killer cell deficiency in humans. JOURNAL OF CLINICAL INVESTIGATION vol. 122, (3) 814-820.
10.1172/JCI60224
Gorrigan RJ, Guasti L, King P, Clark AJ, Chan LF(2011). Localisation of the melanocortin-2-receptor and its accessory proteins in the developing and adult adrenal gland. J Mol Endocrinol vol. 46, (3) 227-232.
10.1530/JME-11-0011
https://qmro.qmul.ac.uk/xmlui/handle/123456789/18354
Guasti L, Paul A, Laufer E, King P(2011). Localization of Sonic hedgehog secreting and receiving cells in the developing and adult rat adrenal cortex. Mol Cell Endocrinol vol. 336, (1-2) 117-122.
10.1016/j.mce.2010.11.010
Igreja S, Chahal HS, King P, Bolger GB, Srirangalingam U, Guasti L, Chapple JP, Trivellin G et al.(2010). Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families. Hum Mutat vol. 31, (8) 950-960.
10.1002/humu.21292
https://qmro.qmul.ac.uk/xmlui/handle/123456789/13186
Laufer E, King P, Paul A(2010). Shh signaling regulates adrenocortical development and identifies novel progenitors of steroidogenic lineages. ENDOCR J vol. 57, S309-S309.
King P, Paul A, Laufer E(2009). Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages. Proc Natl Acad Sci U S A vol. 106, (50) 21185-21190.
10.1073/pnas.0909471106
Bogdarina IG, King PJ, Clark AJL(2009). Characterization of the angiotensin (AT1b) receptor promoter and its regulation by glucocorticoids. J Mol Endocrinol vol. 43, (2) 73-80.
10.1677/JME-09-0036
Garcia EA, King P, Sidhu K, Ohgusu H, Walley A, Lecoeur C, Gueorguiev M, Khalaf S et al.(2009). The role of ghrelin and ghrelin-receptor gene variants and promoter activity in type 2 diabetes. Eur J Endocrinol vol. 161, (2) 307-315.
10.1530/EJE-09-0122
Laufer E, Paul A, King PJ (2009). Shh signaling regulates adrenocortical development and identifies novel progenitors of steroidogenic lineages. DEVELOPMENTAL BIOLOGY. vol. 331, 490-490.
10.1016/j.ydbio.2009.05.387
Chung TT, Webb TR, Chan LF, Cooray SN, Metherell LA, King PJ, Chapple JP, Clark AJL(2008). The majority of adrenocorticotropin receptor (melanocortin 2 receptor) mutations found in familial glucocorticoid deficiency type 1 lead to defective trafficking of the receptor to the cell surface. J Clin Endocrinol Metab vol. 93, (12) 4948-4954.
10.1210/jc.2008-1744
King PJ, Guasti L, Laufer E(2008). Hedgehog signalling in endocrine development and disease. J ENDOCRINOL vol. 198, (3) 439-450.
10.1677/JOE-08-0161
Janes ME, Chu KME, Clark AJL, King PJ(2008). Mechanisms of adrenocorticotropin-induced activation of extracellularly regulated kinase 1/2 mitogen-activated protein kinase in the human H295R adrenal cell line. Endocrinology vol. 149, (4) 1898-1905.
10.1210/en.2007-0949
Doufexis M, Storr HL, King PJ, Clark AJL(2007). Interaction of the melanocortin 2 receptor with nucleoporin 50: evidence for a novel pathway between a G-protein-coupled receptor and the nucleus. FASEB J vol. 21, (14) 4095-4100.
10.1096/fj.06-7927com
Hu L, Monteiro A, Johnston H, King P, O'Shaughnessy PJ(2007). Expression of Cyp21a1 and Cyp11b1 in the fetal mouse testis. REPRODUCTION vol. 134, (4) 585-591.
10.1530/REP-07-0133
Johnston H, King PJ, O'Shaughnessy PJ(2007). Effects of ACTH and expression of the melanocortin-2 receptor in the neonatal mouse testis. REPRODUCTION vol. 133, (6) 1181-1187.
10.1530/REP-06-0359
Bogdarina I, Welham S, King PJ, Burns SP, Clark AJL(2007). Epigenetic modification of the renin-angiotensin system in the fetal programming of hypertension. Circ Res vol. 100, (4) 520-526.
10.1161/01.RES.0000258855.60637.58
Noon LA, Clark AJL, O'Shaughnessy PJ, King PJ(2006). A CCAAT/enhancer-binding protein site at -87 is required for the activation of a novel murine melanocortin 2-receptor promoter at late stages during adipogenesis. Endocrinology vol. 147, (12) 6019-6026.
10.1210/en.2006-0867
Noon LA, Bakmanidis A, Clark AJL, O'Shaughnessy PJ, King PJ(2006). Identification of a novel melanocortin 2 receptor splice variant in murine adipocytes: implications for post-transcriptional control of expression during adipogenesis. J MOL ENDOCRINOL vol. 37, (3) 415-420.
10.1677/jme.1.02023
White NR, Mulligan P, King PJ, Sanderson IR(2006). Sodium butyrate-mediated Sp3 acetylation represses human insulin-like growth factor binding protein-3 expression in intestinal epithelial cells. J Pediatr Gastroenterol Nutr vol. 42, (2) 134-141.
10.1097/01.mpg.0000189345.31010.89
Noon LA, Clark AJL, King PJ(2004). A peroxisome proliferator-response element in the murine mc2-r promoter regulates its transcriptional activation during differentiation of 3T3-L1 adipocytes. J Biol Chem vol. 279, (22) 22803-22808.
10.1074/jbc.M401861200
King P, CLARK AJL, Noon LA(2004). A Peroxisome Proliferator-response Element in the Murine mc2-r Promoter Regulates Its Transcriptional Activation during Differentiation of 3T3-L1 Adipocytes. Journal of Biological Chemistry vol. 279, (22) 22803-22808.
10.1074/jbc.M401861200
Swords FM, Noon LA, King PJ, Clark AJL(2004). Constitutive activation of the human ACTH receptor resulting from a synergistic interaction between two naturally occurring missense mutations in the MC2R gene. Mol Cell Endocrinol vol. 213, (2) 149-154.
10.1016/j.mce.2003.10.052
Fowkes RC, Desclozeaux M, Patel MV, Aylwin SJB, King P, Ingraham HA, Burrin JM(2003). Steroidogenic factor-1 and the gonadotrope-specific element enhance basal and pituitary adenylate cyclase-activating polypeptide-stimulated transcription of the human glycoprotein hormone alpha-subunit gene in gonadotropes. MOL ENDOCRINOL vol. 17, (11) 2177-2188.
10.1210/me.2002-0393
Fowkes RC, Sidhu KK, Sosabowski JK, King P, Burrin JM(2003). Absence of pituitary adenylate cyclase-activating polypeptide-stimulated transcription of the human glycoprotein alpha-subunit gene in LbetaT2 gonadotrophs reveals disrupted cAMP-mediated gene transcription. J Mol Endocrinol vol. 31, (2) 263-278.
10.1677/jme.0.0310263
Clark AJL, Baig AH, Noon L, Swords FM, Hunyady L, King PJ (2003). Expression, desensitization, and internalization of the ACTH receptor (MC2R). MELANOCORTIN SYSTEM. Editors: Cone, RD, vol. 994, 111-117.
10.1111/j.1749-6632.2003.tb03169.x
Swords FM, Baig A, Malchoff DM, Malchoff CD, Thorner MO, King PJ, Hunyady L, Clark AJL(2002). Impaired desensitization of a mutant adrenocorticotropin receptor associated with apparent constitutive activity. Mol Endocrinol vol. 16, (12) 2746-2753.
10.1210/me.2002-0099
Baig AH, Swords FM, Szaszák M, King PJ, Hunyady L, Clark AJL(2002). Agonist activated adrenocorticotropin receptor internalizes via a clathrin-mediated G protein receptor kinase dependent mechanism. Endocr Res vol. 28, (4) 281-289.
10.1081/erc-120016798
Kosti O, King PJ, Hinson JP(2002). Tumour-derived human adrenocortical cells express beta-adrenergic receptors: steroidogenic effects of beta-adrenergic input. Endocr Res vol. 28, (4) 363-367.
10.1081/erc-120016810
Fowkes RC, King P, Burrin JM(2002). Regulation of human glycoprotein hormone alpha-subunit gene transcription in L beta T2 gonadotropes by protein kinase C and extracellular signal-regulated kinase 1/2. BIOL REPROD vol. 67, (3) 725-734.
10.1095/biolreprod67.3.725
Noon LA, Franklin JM, King PJ, Goulding NJ, Hunyady L, Clark AJL(2002). Failed export of the adrenocorticotrophin receptor from the endoplasmic reticulum in non-adrenal cells: evidence in support of a requirement for a specific adrenal accessory factor. J Endocrinol vol. 174, (1) 17-25.
10.1677/joe.0.1740017
Baig AH, Swords FM, Noon LA, King PJ, Hunyady L, Clark AJ(2001). Desensitization of the Y1 cell adrenocorticotropin receptor: evidence for a restricted heterologous mechanism implying a role for receptor-effector complexes. J Biol Chem vol. 276, (48) 44792-44797.
10.1074/jbc.M108572200
Newell-Price J, King P, Clark AJ(2001). The CpG island promoter of the human proopiomelanocortin gene is methylated in nonexpressing normal tissue and tumors and represses expression. Mol Endocrinol vol. 15, (2) 338-348.
10.1210/mend.15.2.0599
KING PJ, Clark AJL, Newell-Price J(2001). Methylation of a tissue-specific CpG island in normal non-expressing human tissue. Mol Endo vol. 15, 338-348.
Newell-Price J, Clark AJL, King P(2000). DNA methylation and silencing of gene expression. Trends in Endocrinology and Metabolism vol. 11, (4) 142-148.
10.1016/S1043-2760(00)00248-4
King PJ, Clark AJL (1998). Analysis of the first exon of the murine ACTH receptor gene. Endocrine Research. vol. 24, 397-402.
10.3109/07435809809032621
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