Publications: Dr Peter King
Novoselova TV, King PJ, Guasti L, Metherell LA, Clark AJL, Chan LF
(
2019
)
.
ACTH signalling and adrenal development: Lessons from mouse models
.
Endocrine Connections
vol.
8
,
(
7
)
R122
-
R130
.
Hadjidemetriou I, Mariniello K, Ruiz-Babot G, Pittaway J, Mancini A, Mariannis D, Gomez-Sanchez CE, Parvanta L et al.
(
2019
)
.
DLK1/PREF1 marks a novel cell population in the human adrenal cortex
.
The Journal of Steroid Biochemistry and Molecular Biology
vol.
193
,
O’Toole SM, Watson DS, Novoselova TV, Romano LEL, King PJ, Bradshaw TY, Thompson CL, Knight MM et al.
(
2019
)
.
Oncometabolite induced primary cilia loss in pheochromocytoma
.
Endocrine-Related Cancer
vol.
26
,
(
1
)
165
-
180
.
Novoselova TV, Hussain M, King PJ, Guasti L, Metherell LA, Charalambous M, Clark AJL, Chan LF
(
2018
)
.
MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation
.
FASEB Journal
vol.
32
,
(
11
)
6186
-
6196
.
Read JE, Cabrera-Sharp V, Kitscha P, Cartwright JE, King PJ, Fowkes RC, de Mestre AM
(
2018
)
.
Glial Cells Missing 1 Regulates Equine Chorionic Gonadotrophin Beta Subunit via Binding to the Proximal Promoter
.
Frontiers in Endocrinology
vol.
9
,
195
-
195
.
Johnston ZC, Bellingham M, Filis P, Soffientini U, Hough D, Bhattacharya S, Simard M, Hammond GL et al.
(
2018
)
.
The human fetal adrenal produces cortisol but no detectable aldosterone throughout the second trimester
.
BMC Med
vol.
16
,
(
1
)
23
-
23
.
Ruiz-Babot G, Balyura M, Hadjidemetriou I, Ajodha SJ, Taylor DR, Ghataore L, Taylor NF, Schubert U et al.
(
2018
)
.
Modeling Congenital Adrenal Hyperplasia and Testing Interventions for Adrenal Insufficiency Using Donor-Specific Reprogrammed Cells
.
Cell Reports
vol.
22
,
(
5
)
1236
-
1249
.
Katugampola H, King PJ, Chatterjee S, Meso M, Duncan AJ, Achermann JC, Guasti L, Ghataore L et al.
(
2017
)
.
Kisspeptin is a novel regulator of human fetal adrenocortical development and function – a finding with important implications for the human feto-placental unit
.
The Journal of Clinical Endocrinology & Metabolism
Cavlan D, Evagora C, Berney D, Storr H, Drake W, King P
(
2016
)
.
Adrenal pigmentation in PPNAD is a result of melanin deposition and associated with upregulation of the melanocortin 1 receptor
.
Endocrine Abstracts
Hawkins KE, Joy S, Delhove JMKM, Kotiadis VN, Fernandez E, Fitzpatrick LM, Whiteford JR, King PJ et al.
(
2016
)
.
NRF2 Orchestrates the Metabolic Shift during Induced Pluripotent Stem Cell Reprogramming
.
Cell Reports
vol.
14
,
(
8
)
1883
-
1891
.
Cavlan D, Storr H, Berney D, Evagora C, King P
(
2015
)
.
Adrenal pigmentation in PPNAD is a result of melanin deposition and associated with upregulation of the melanocortin 1 receptor
.
Endocrine Abstracts
Hadjidemetriou I, Ruiz-Babot G, Gomez-Sanchez C, King P, Guasti L
(
2015
)
.
Unveiling the complexity of the undifferentiated zone in the human adrenal cortex
.
Endocrine Abstracts
Diaz-Cano S, Szyszka P, Weitsman G, Dudka D, King P, Korbonits M, Grossman A, Schulte K-M et al.
(
2015
)
.
Effect of Erlotinib on Proliferation and Steriodogenesis in Primary Cultures of Adrenocortical Carcinoma
.
LABORATORY INVESTIGATION
.
vol.
95
,
133A
-
133A
.
Ruiz-Babot G, Hadjidemetriou I, King PJ, Guasti L
(
2015
)
.
New directions for the treatment of adrenal insufficiency
.
Frontiers in Endocrinology
vol.
6
,
(
MAY
)
Katugampola H, Halder W, Ganatra R, Dunkel L, Storr H, Guasti L, King P
(
2014
)
.
Expression of Sonic hedgehog signalling components in the developing human adrenal cortex
.
Endocrine Abstracts
Dworakowska D, Dudka D, Weitsman G, King PJ, Diaz-Cano SJ, Korbonits M, Grossman AB, Aylwin SJB et al.
(
2014
)
.
Simultaneous Targeting PI3K/Akt/mTOR and MEK/RAF/ERK Pathways Results in a Synergistic Anti-Proliferative Effect in an Adrenocortical Carcinoma Model
.
ENDOCRINE REVIEWS
vol.
35
,
(
3
)
Dworakowska D, Dudka D, Weistman G, King P, Diaz-Cano S, Korbonits M, Grossman AB, Aylwin S et al.
(
2014
)
.
The anti-proliferative effect of anti-EGFR tyrosine kinase inhibitor in combination with mitotane on H295R adrenocortical cancer cells
.
Endocrine Abstracts
Radian S, King P, Korbonits M
(
2014
)
.
Analysis of the AIP gene promoter
.
Endocrine Abstracts
Dworakowska D, Dudka D, Weitsman G, King P, Katugampola H, Korbonits M, Schulte K-M, Diaz-Cano S et al.
(
2014
)
.
Pre-clinical assessment of the impact of Erlotinib on adrenocortical cancer cells proliferation
.
Endocrine Abstracts
Guasti L, Cavlan D, Cogger K, Banu Z, Shakur A, Latif S, King PJ
(
2013
)
.
Dlk1 up-regulates Gli1 expression in male rat adrenal capsule cells through the activation of β1 integrin and ERK1/2
.
Endocrinology
vol.
154
,
(
12
)
4675
-
4684
.
Guasti L, Candy Sze WC, McKay T, Grose R, King PJ
(
2013
)
.
FGF signalling through Fgfr2 isoform IIIb regulates adrenal cortex development
.
Mol Cell Endocrinol
vol.
371
,
(
1-2
)
182
-
188
.
Meimaridou E, Hughes CR, Kowalczyk J, Guasti L, Chapple JP, King PJ, Chan LF, Clark AJL et al.
(
2013
)
.
Familial glucocorticoid deficiency: New genes and mechanisms
.
Molecular and Cellular Endocrinology
vol.
371
,
(
1-2
)
195
-
200
.
Meimaridou E, Hughes CR, Kowalczyk J, Guasti L, Chapple JP, King PJ, Chan LF, Clark AJL et al.
(
2013
)
.
Familial glucocorticoid deficiency: New genes and mechanisms
.
Mol Cell Endocrinol
vol.
371
,
(
1-2
)
195
-
200
.
Yates R, Katugampola H, Cavlan D, Cogger K, Meimaridou E, Hughes C, Metherell L, Guasti L et al.
(
2013
)
.
Adrenocortical development, maintenance, and disease
.
Curr Top Dev Biol
vol.
106
,
239
-
312
.
Cogger K, Guasti L, Ashworth R, Brennan C, Beales P, Marion V, King P
(
2012
)
.
The role of primary cilia in mouse adrenal and zebrafish interrenal development
.
Cilia
vol.
1
,
(
Suppl 1
)
Marion V, Mockel A, De Melo C, Obringer C, Claussmann A, Simon A, Messaddeq N, Durand M et al.
(
2012
)
.
BBS-Induced Ciliary Defect Enhances Adipogenesis, Causing Paradoxical Higher-Insulin Sensitivity, Glucose Usage, and Decreased Inflammatory Response
.
CELL METABOLISM
vol.
16
,
(
3
)
363
-
377
.
Thompson IR, Chand AN, King PJ, Ansorge O, Karavitaki N, Jones CA, Rahmutula D, Gardner DG et al.
(
2012
)
.
Expression of guanylyl cyclase-B (GC-B/NPR2) receptors in normal human fetal pituitaries and human pituitary adenomas implicates a role for C-type natriuretic peptide
.
Endocr Relat Cancer
vol.
19
,
(
4
)
497
-
508
.
Meimaridou E, Kowalczyk J, Guasti L, Hughes CR, Wagner F, Frommolt P, Nürnberg P, Mann NP et al.
(
2012
)
.
Mutations in NNT encoding nicotinamide nucleotide transhydrogenase cause familial glucocorticoid deficiency
.
Nat Genet
vol.
44
,
(
7
)
740
-
742
.
Laufer E, Kesper D, Vortkamp A, King P
(
2012
)
.
Sonic hedgehog signaling during adrenal development
.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
vol.
351
,
(
1
)
19
-
27
.
Hughes CR, Guasti L, Meimaridou E, Chuang C-H, Schimenti JC, King PJ, Costigan C, Clark AJL et al.
(
2012
)
.
MCM4 mutation causes adrenal failure, short stature, and natural killer cell deficiency in humans
.
JOURNAL OF CLINICAL INVESTIGATION
vol.
122
,
(
3
)
814
-
820
.
Gorrigan RJ, Guasti L, King P, Clark AJ, Chan LF
(
2011
)
.
Localisation of the melanocortin-2-receptor and its accessory proteins in the developing and adult adrenal gland
.
J Mol Endocrinol
vol.
46
,
(
3
)
227
-
232
.
Guasti L, Paul A, Laufer E, King P
(
2011
)
.
Localization of Sonic hedgehog secreting and receiving cells in the developing and adult rat adrenal cortex
.
Mol Cell Endocrinol
vol.
336
,
(
1-2
)
117
-
122
.
Igreja S, Chahal HS, King P, Bolger GB, Srirangalingam U, Guasti L, Chapple JP, Trivellin G et al.
(
2010
)
.
Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families
.
Hum Mutat
vol.
31
,
(
8
)
950
-
960
.
Laufer E, King P, Paul A
(
2010
)
.
Shh signaling regulates adrenocortical development and identifies novel progenitors of steroidogenic lineages
.
ENDOCR J
vol.
57
,
S309
-
S309
.
King P, Paul A, Laufer E
(
2009
)
.
Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages
.
Proc Natl Acad Sci U S A
vol.
106
,
(
50
)
21185
-
21190
.
Bogdarina IG, King PJ, Clark AJL
(
2009
)
.
Characterization of the angiotensin (AT1b) receptor promoter and its regulation by glucocorticoids
.
J Mol Endocrinol
vol.
43
,
(
2
)
73
-
80
.
Garcia EA, King P, Sidhu K, Ohgusu H, Walley A, Lecoeur C, Gueorguiev M, Khalaf S et al.
(
2009
)
.
The role of ghrelin and ghrelin-receptor gene variants and promoter activity in type 2 diabetes
.
Eur J Endocrinol
vol.
161
,
(
2
)
307
-
315
.
Laufer E, Paul A, King PJ
(
2009
)
.
Shh signaling regulates adrenocortical development and identifies novel progenitors of steroidogenic lineages
.
DEVELOPMENTAL BIOLOGY
.
vol.
331
,
490
-
490
.
Chung TT, Webb TR, Chan LF, Cooray SN, Metherell LA, King PJ, Chapple JP, Clark AJL
(
2008
)
.
The majority of adrenocorticotropin receptor (melanocortin 2 receptor) mutations found in familial glucocorticoid deficiency type 1 lead to defective trafficking of the receptor to the cell surface
.
J Clin Endocrinol Metab
vol.
93
,
(
12
)
4948
-
4954
.
King PJ, Guasti L, Laufer E
(
2008
)
.
Hedgehog signalling in endocrine development and disease
.
J ENDOCRINOL
vol.
198
,
(
3
)
439
-
450
.
Janes ME, Chu KME, Clark AJL, King PJ
(
2008
)
.
Mechanisms of adrenocorticotropin-induced activation of extracellularly regulated kinase 1/2 mitogen-activated protein kinase in the human H295R adrenal cell line
.
Endocrinology
vol.
149
,
(
4
)
1898
-
1905
.
Doufexis M, Storr HL, King PJ, Clark AJL
(
2007
)
.
Interaction of the melanocortin 2 receptor with nucleoporin 50: evidence for a novel pathway between a G-protein-coupled receptor and the nucleus
.
FASEB J
vol.
21
,
(
14
)
4095
-
4100
.
Hu L, Monteiro A, Johnston H, King P, O'Shaughnessy PJ
(
2007
)
.
Expression of Cyp21a1 and Cyp11b1 in the fetal mouse testis
.
REPRODUCTION
vol.
134
,
(
4
)
585
-
591
.
Johnston H, King PJ, O'Shaughnessy PJ
(
2007
)
.
Effects of ACTH and expression of the melanocortin-2 receptor in the neonatal mouse testis
.
REPRODUCTION
vol.
133
,
(
6
)
1181
-
1187
.
Bogdarina I, Welham S, King PJ, Burns SP, Clark AJL
(
2007
)
.
Epigenetic modification of the renin-angiotensin system in the fetal programming of hypertension
.
Circ Res
vol.
100
,
(
4
)
520
-
526
.
Noon LA, Clark AJL, O'Shaughnessy PJ, King PJ
(
2006
)
.
A CCAAT/enhancer-binding protein site at -87 is required for the activation of a novel murine melanocortin 2-receptor promoter at late stages during adipogenesis
.
Endocrinology
vol.
147
,
(
12
)
6019
-
6026
.
Noon LA, Bakmanidis A, Clark AJL, O'Shaughnessy PJ, King PJ
(
2006
)
.
Identification of a novel melanocortin 2 receptor splice variant in murine adipocytes: implications for post-transcriptional control of expression during adipogenesis
.
J MOL ENDOCRINOL
vol.
37
,
(
3
)
415
-
420
.
White NR, Mulligan P, King PJ, Sanderson IR
(
2006
)
.
Sodium butyrate-mediated Sp3 acetylation represses human insulin-like growth factor binding protein-3 expression in intestinal epithelial cells
.
J Pediatr Gastroenterol Nutr
vol.
42
,
(
2
)
134
-
141
.
Noon LA, Clark AJL, King PJ
(
2004
)
.
A peroxisome proliferator-response element in the murine mc2-r promoter regulates its transcriptional activation during differentiation of 3T3-L1 adipocytes
.
J Biol Chem
vol.
279
,
(
22
)
22803
-
22808
.
King P, CLARK AJL, Noon LA
(
2004
)
.
A Peroxisome Proliferator-response Element in the Murine mc2-r Promoter Regulates Its Transcriptional Activation during Differentiation of 3T3-L1 Adipocytes
.
Journal of Biological Chemistry
vol.
279
,
(
22
)
22803
-
22808
.
Swords FM, Noon LA, King PJ, Clark AJL
(
2004
)
.
Constitutive activation of the human ACTH receptor resulting from a synergistic interaction between two naturally occurring missense mutations in the MC2R gene
.
Mol Cell Endocrinol
vol.
213
,
(
2
)
149
-
154
.
Fowkes RC, Desclozeaux M, Patel MV, Aylwin SJB, King P, Ingraham HA, Burrin JM
(
2003
)
.
Steroidogenic factor-1 and the gonadotrope-specific element enhance basal and pituitary adenylate cyclase-activating polypeptide-stimulated transcription of the human glycoprotein hormone alpha-subunit gene in gonadotropes
.
MOL ENDOCRINOL
vol.
17
,
(
11
)
2177
-
2188
.
Fowkes RC, Sidhu KK, Sosabowski JK, King P, Burrin JM
(
2003
)
.
Absence of pituitary adenylate cyclase-activating polypeptide-stimulated transcription of the human glycoprotein alpha-subunit gene in LbetaT2 gonadotrophs reveals disrupted cAMP-mediated gene transcription
.
J Mol Endocrinol
vol.
31
,
(
2
)
263
-
278
.
Clark AJL, Baig AH, Noon L, Swords FM, Hunyady L, King PJ
(
2003
)
.
Expression, desensitization, and internalization of the ACTH receptor (MC2R)
.
MELANOCORTIN SYSTEM
.
Editors:
Cone, RD
,
vol.
994
,
111
-
117
.
Swords FM, Baig A, Malchoff DM, Malchoff CD, Thorner MO, King PJ, Hunyady L, Clark AJL
(
2002
)
.
Impaired desensitization of a mutant adrenocorticotropin receptor associated with apparent constitutive activity
.
Mol Endocrinol
vol.
16
,
(
12
)
2746
-
2753
.
Baig AH, Swords FM, Szaszák M, King PJ, Hunyady L, Clark AJL
(
2002
)
.
Agonist activated adrenocorticotropin receptor internalizes via a clathrin-mediated G protein receptor kinase dependent mechanism
.
Endocr Res
vol.
28
,
(
4
)
281
-
289
.
Kosti O, King PJ, Hinson JP
(
2002
)
.
Tumour-derived human adrenocortical cells express beta-adrenergic receptors: steroidogenic effects of beta-adrenergic input
.
Endocr Res
vol.
28
,
(
4
)
363
-
367
.
Fowkes RC, King P, Burrin JM
(
2002
)
.
Regulation of human glycoprotein hormone alpha-subunit gene transcription in L beta T2 gonadotropes by protein kinase C and extracellular signal-regulated kinase 1/2
.
BIOL REPROD
vol.
67
,
(
3
)
725
-
734
.
Noon LA, Franklin JM, King PJ, Goulding NJ, Hunyady L, Clark AJL
(
2002
)
.
Failed export of the adrenocorticotrophin receptor from the endoplasmic reticulum in non-adrenal cells: evidence in support of a requirement for a specific adrenal accessory factor
.
J Endocrinol
vol.
174
,
(
1
)
17
-
25
.
Baig AH, Swords FM, Noon LA, King PJ, Hunyady L, Clark AJ
(
2001
)
.
Desensitization of the Y1 cell adrenocorticotropin receptor: evidence for a restricted heterologous mechanism implying a role for receptor-effector complexes
.
J Biol Chem
vol.
276
,
(
48
)
44792
-
44797
.
Newell-Price J, King P, Clark AJ
(
2001
)
.
The CpG island promoter of the human proopiomelanocortin gene is methylated in nonexpressing normal tissue and tumors and represses expression
.
Mol Endocrinol
vol.
15
,
(
2
)
338
-
348
.
KING PJ, Clark AJL, Newell-Price J
(
2001
)
.
Methylation of a tissue-specific CpG island in normal non-expressing human tissue
.
Mol Endo
vol.
15
,
338
-
348
.
Newell-Price J, Clark AJL, King P
(
2000
)
.
DNA methylation and silencing of gene expression
.
Trends in Endocrinology and Metabolism
vol.
11
,
(
4
)
142
-
148
.
King PJ, Clark AJL
(
1998
)
.
Analysis of the first exon of the murine ACTH receptor gene
.
Endocrine Research
.
vol.
24
,
397
-
402
.