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Publications:  Prof Martin Knight

Torres-Pérez JV, Naeem H, Thompson CL, Knight MM, Novak P(2020). Nanoscale mapping reveals functional differences in ion channels populating the membrane of primary cilia. Cellular Physiology and Biochemistry vol. 54, (1) 15-26.
10.33594/000000202
Fu S, Meng H, Freer F, Kwon J, Shelton JC, Knight MM(2020). Sub-toxic levels of Co<sup>2+</sup> are anti-inflammatory and protect cartilage from degradation caused by IL-1β. Clinical Biomechanics
10.1016/j.clinbiomech.2019.12.006
Walker RV, Keynton JL, Grimes DT, Sreekumar V, Williams DJ, Esapa C, Wu D, Knight MM et al.(2019). Ciliary exclusion of Polycystin-2 promotes kidney cystogenesis in an autosomal dominant polycystic kidney disease model. Nature Communications vol. 10, (1)
10.1038/s41467-019-12067-y
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59821
Delaine-Smith R, Wright N, Hanley CJ, Hanwell R, Bhome R, Bullock M, Drifka CR, Eliceiri KW et al. (2019). Transglutaminase-2 mediates stromal biomechanics in colorectal cancer. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 100, A15-A16.
Inamdar SR, Barbieri E, Terrill NJ, Knight MM, Gupta HS(2019). Proteoglycan degradation mimics static compression by altering the natural gradients in fibrillar organisation in cartilage. Acta Biomaterialia vol. 97, 437-450.
10.1016/j.actbio.2019.07.055
https://qmro.qmul.ac.uk/xmlui/handle/123456789/61619
Fu S, Thompson CL, Ali A, Wang W, Chapple JP, Mitchison HM, Beales PL, Wann AKT et al.(2019). Mechanical loading inhibits cartilage inflammatory signalling via an HDAC6 and IFT-dependent mechanism regulating primary cilia elongation. Osteoarthritis and Cartilage vol. 27, (7) 1064-1074.
10.1016/j.joca.2019.03.003
https://qmro.qmul.ac.uk/xmlui/handle/123456789/56961
Delaine-Smith R, Wright N, Hanley C, Hanwell R, Bhome R, Bullock M, Drifka C, Eliceiri K et al.(2019). Transglutaminase-2 Mediates the Biomechanical Properties of the Colorectal Cancer Tissue Microenvironment that Contribute to Disease Progression. Cancers
10.3390/cancers11050701
https://qmro.qmul.ac.uk/xmlui/handle/123456789/57778
Harris C, THORPE SD, Rushwan S, Wang W, THOMPSON C, Peacock J, KNIGHT M, Gooptu B et al.(2019). An in vitro investigation of the inflammatory response to the strain amplitudes which occur during high frequency oscillation ventilation and conventional mechanical ventilation. Journal of Biomechanics
10.1016/j.jbiomech.2019.03.024
https://qmro.qmul.ac.uk/xmlui/handle/123456789/56712
O¿Toole SM, Watson DS, Novoselova TV, Romano LEL, King PJ, Bradshaw TY, Thompson CL, Knight MM et al.(2019). Oncometabolite induced primary cilia loss in pheochromocytoma. Endocrine-Related Cancer vol. 26, (1) 165-180.
10.1530/ERC-18-0134
https://qmro.qmul.ac.uk/xmlui/handle/123456789/44923
Pearce OMT, Nichols S, Delaine-Smith R, Jones RR, Maniati E, Rootizalab R, Mackerodt J, Knight MM et al. (2018). Investigating drivers of the tumour matrisome, and their role in disease progression. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 99, A49-A49.
Rowson DT, Shelton JC, Screen HRC, Knight MM(2018). Mechanical loading induces primary cilia disassembly in tendon cells via TGFβ and HDAC6. Scientific Reports vol. 8, (1)
10.1038/s41598-018-29502-7
https://qmro.qmul.ac.uk/xmlui/handle/123456789/48069
Xu J, Nyga A, Li W, Zhang X, Gavara N, Knight MM, Shelton JC(2018). Cobalt ions stimulate a fibrotic response through matrix remodelling, fibroblast contraction and release of pro-fibrotic signals from macrophages. European Cells and Materials vol. 36, 142-155.
10.22203/eCM.v036a11
https://qmro.qmul.ac.uk/xmlui/handle/123456789/46044
Kenny FN, Drymoussi Z, Delaine-Smith R, Kao AP, Laly AC, Knight MM, Philpott MP, Connelly JT(2018). Tissue stiffening promotes keratinocyte proliferation through activation of epidermal growth factor signaling. Journal of Cell Science vol. 131, (10)
10.1242/jcs.215780
https://qmro.qmul.ac.uk/xmlui/handle/123456789/39445
Xu J, Yang J, Nyga A, Ehteramyan M, Moraga A, Wu Y, Zeng L, Knight MM et al.(2018). Cobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated down-regulation of RhoA expression. Acta Biomater vol. 72, 434-446.
10.1016/j.actbio.2018.03.054
https://qmro.qmul.ac.uk/xmlui/handle/123456789/48068
Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D et al.(2017). Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers. Cancer Discov
10.1158/2159-8290.CD-17-0284
https://qmro.qmul.ac.uk/xmlui/handle/123456789/30984
Gambassi S, Geminiani M, Thorpe SD, Bernardini G, Millucci L, Braconi D, Orlandini M, Thompson CL et al.(2017). Smoothened-antagonists reverse homogentisic acid-induced alterations of Hedgehog signaling and primary cilium length in alkaptonuria. Journal of Cellular Physiology vol. 232, (11) 3103-3111.
10.1002/jcp.25761
https://qmro.qmul.ac.uk/xmlui/handle/123456789/18493
Thompson CL, Plant JC, Wann AK, Bishop CL, Novak P, Mitchison HM, Beales PL, Chapple JP et al.(2017). Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling. Eur Cell Mater vol. 34, 128-141.
10.22203/eCM.v034a09
https://qmro.qmul.ac.uk/xmlui/handle/123456789/26203
Inamdar SR, Knight DP, Terrill NJ, Karunaratne A, Cacho-Nerin F, Knight MM, Gupta HS(2017). The Secret Life of Collagen: Temporal Changes in Nanoscale Fibrillar Pre-Strain and Molecular Organization During Physiological Loading of Cartilage. ACS Nano
10.1021/acsnano.7b00563
https://qmro.qmul.ac.uk/xmlui/handle/123456789/25661
Zhang J, Dalbay MT, Luo X, Vrij E, Barbieri D, Moroni L, de Bruijn JD, van Blitterswijk CA et al.(2017). Topography of calcium phosphate ceramics regulates primary cilia length and TGF receptor recruitment associated with osteogenesis. Acta Biomater vol. 57, 487-497.
10.1016/j.actbio.2017.04.004
https://qmro.qmul.ac.uk/xmlui/handle/123456789/22603
THORPE SD, Gambassi S, Thompson CL, Chandrakumar C, Santucci A, Knight MM(2017). Reduced Primary Cilia Length and Altered Arl13b Expression Are Associated with Deregulated Chondrocyte Hedgehog Signalling in Alkaptonuria. Journal of Cellular Physiology
10.1002/jcp.25839
https://qmro.qmul.ac.uk/xmlui/handle/123456789/19413
Rowson DT, Knight MM, Screen HRC (2017). Cyclic loading leads to primary cilia disassembly in human tenocytes. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 98, A6-A6.
https://qmro.qmul.ac.uk/xmlui/handle/123456789/24784
Thompson CL, Chapple JP, Beales PL, Mitchison HM, Ramachandran M, Knight MM (2017). Polycystins are required for primary cilia-mediated mechanotransduction in chondrocytes. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 98, A14-A14.
https://qmro.qmul.ac.uk/xmlui/handle/123456789/56620
Knight MM (2017). Primary cilia mechanobiology. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 98, A3-A4.
https://qmro.qmul.ac.uk/xmlui/handle/123456789/56693
Gooptu B, Rushwan S, Wang W, Harris C, Thorpe S, Knight M, Sethi T (2017). A Cd98hc-Dependent Mechanism Mediates Pro-Inflammatory Cytokine Release In Cell And Animal Models Of Lung Injury. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. vol. 195,
https://qmro.qmul.ac.uk/xmlui/handle/123456789/56694
Delaine-Smith RM, Burney S, Balkwill FR, Knight MM(2016). Experimental validation of a flat punch indentation methodology calibrated against unconfined compression tests for determination of soft tissue biomechanics. Journal of the Mechanical Behavior of Biomedical Materials vol. 60, 401-415.
10.1016/j.jmbbm.2016.02.019
Sliogeryte K, Botto L, Lee DA, Knight MM(2016). Chondrocyte dedifferentiation increases cell stiffness by strengthening membrane-actin adhesion. Osteoarthritis and Cartilage vol. 24, (5) 912-920.
10.1016/j.joca.2015.12.007
https://qmro.qmul.ac.uk/xmlui/handle/123456789/10785
Thorpe SD, Gambassi S, Patel R, Santucci A, Knight MM (2016). CHANGES IN CHONDROCYTE PRIMARY CILIA STRUCTURE AND FUNCTION ARE ASSOCIATED WITH ALTERED MECHANOREGULATION IN ALKAPTONURIA. OSTEOARTHRITIS AND CARTILAGE. vol. 24, S174-S175.
10.1016/j.joca.2016.01.343
https://qmro.qmul.ac.uk/xmlui/handle/123456789/23706
Kelly T-AN, Thompson CL, Tan E, Wann AK, Thorpe SD, Chapple JP, Hung CT, Knight MM (2016). Chondrocyte dedifferentiation down regulates mechano-responsiveness and hedgehog signalling associated with changes in primary cilia structure. Osteoarthritis and Cartilage. Conference: World Congress of the Osteoarthritis-Research-Society-International (OARSI) on Osteoarthritis from: 31/03/2016 to: 03/04/2016, vol. 24, S342-S343.
10.1016/j.joca.2016.01.614
Rowson D, Knight MM, Screen HRC(2016). Zonal variation in primary cilia elongation correlates with localized biomechanical degradation in stress deprived tendon. J Orthop Res vol. 34, (12) 2146-2153.
10.1002/jor.23229
https://qmro.qmul.ac.uk/xmlui/handle/123456789/23401
Wang Z, Wann AKT, Thompson CL, Hassen A, Wang W, Knight MM(2016). IFT88 influences chondrocyte actin organization and biomechanics. Osteoarthritis and cartilage vol. 24, (3) 544-554.
10.1016/j.joca.2015.10.003
https://qmro.qmul.ac.uk/xmlui/handle/123456789/9613
Thompson CL, Wiles A, Poole CA, Knight MM(2016). Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling. FASEB Journal vol. 30, (2) 716-726.
10.1096/fj.15-274944
https://qmro.qmul.ac.uk/xmlui/handle/123456789/9616
Sliogeryte K, Thorpe SD, Wang Z, Thompson CL, Gavara N, Knight MM(2016). Differential effects of LifeAct-GFP and actin-GFP on cell mechanics assessed using micropipette aspiration. Journal of Biomechanics vol. 49, (2) 310-317.
10.1016/j.jbiomech.2015.12.034
https://qmro.qmul.ac.uk/xmlui/handle/123456789/35743
Thompson CL, Patel R, Kelly T-AN, Wann AKT, Hung CT, Chapple JP, Knight MM(2015). Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β. Arthritis Research & Therapy vol. 17, (1)
10.1186/s13075-015-0891-z
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15847
Tan AR, VandenBerg CD, Attur M, Abramson SB, Knight MM, Bulinski JC, Ateshian GA, Cook JL et al.(2015). Cytokine preconditioning of engineered cartilage provides protection against interleukin-1 insult. Arthritis Res Ther vol. 17, 361-361.
10.1186/s13075-015-0876-y
https://qmro.qmul.ac.uk/xmlui/handle/123456789/16130
Thompson CL, Poole CA, Knight MM(2015). Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling. The FASEB Journal vol. 100, (4) A39-A40.
10.1096/fj.15-274944
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62499
KNIGHT MM, Thompson CL, Yasmin H, Varone A, Wiles A, Poole CA(2015). Lithium chloride prevents interleukin- 1β induced cartilage degradation and loss of mechanical properties. Journal of Orthopaedic Research
10.1002/jor.22913
https://qmro.qmul.ac.uk/xmlui/handle/123456789/16043
Dalbay MT, Thorpe SD, Connelly JT, Chapple JP, Knight MM(2015). Adipogenic differentiation of hMSCs is mediated by recruitment of IGF-1r onto the primary cilium associated with cilia elongation. Stem Cells vol. 33, (6) 1952-1961.
10.1002/stem.1975
https://qmro.qmul.ac.uk/xmlui/handle/123456789/7323
Chen J, Bader DL, Lee DA, Knight MM(2015). FINITE ELEMENT ANALYSIS of MECHANICAL DEFORMATION of CHONDROCYTE to 2D SUBSTRATE and 3D SCAFFOLD. Journal of Mechanics in Medicine and Biology vol. 15, (5)
10.1142/S0219519415500773
Wang Z, Irianto J, Kazun S, Wang W, Knight MM(2015). The rate of hypo-osmotic challenge influences regulatory volume decrease (RVD) and mechanical properties of articular chondrocytes. Osteoarthritis and Cartilage vol. 23, (2) 289-299.
10.1016/j.joca.2014.11.003
https://qmro.qmul.ac.uk/xmlui/handle/123456789/9918
Wann AKT, Chapple JP, Knight MM(2014). The primary cilium influences interleukin-1β-induced NFκB signalling by regulating IKK activity. Cell Signal vol. 26, (8) 1735-1742.
10.1016/j.cellsig.2014.04.004
https://qmro.qmul.ac.uk/xmlui/handle/123456789/9632
Shaheen T, Edirisinghe T, Gabriel M, Bourdoumis A, Buchholz N, Knight M(2014). In vitro encrustation of a semi-permanent polymer-covered nitinol ureter stent: an artificial urine model. UROLITHIASIS vol. 42, (3) 203-207.
10.1007/s00240-014-0652-5
Thompson CL, Chapple JP, Knight MM(2014). Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes. Osteoarthritis Cartilage vol. 22, (3) 490-498.
10.1016/j.joca.2013.12.016
https://qmro.qmul.ac.uk/xmlui/handle/123456789/9635
Irianto J, Lee DA, Knight MM(2014). Quantification of chromatin condensation level by image processing. Med Eng Phys vol. 36, (3) 412-417.
10.1016/j.medengphy.2013.09.006
Irianto J, Ramaswamy G, Serra R, Knight MM(2014). Depletion of chondrocyte primary cilia reduces the compressive modulus of articular cartilage. J Biomech vol. 47, (2) 579-582.
10.1016/j.jbiomech.2013.11.040
https://qmro.qmul.ac.uk/xmlui/handle/123456789/9612
Sliogeryte K, Thorpe SD, Lee DA, Botto L, Knight MM(2014). Stem cell differentiation increases membrane-actin adhesion regulating cell blebability, migration and mechanics. Scientific Reports vol. 4,
10.1038/srep07307
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6929
McMurray RJ, Wann AKT, Thompson CL, Connelly JT, Knight MM(2013). Surface topography regulates wnt signaling through control of primary cilia structure in mesenchymal stem cells. Sci Rep vol. 3,
10.1038/srep03545
https://qmro.qmul.ac.uk/xmlui/handle/123456789/54206
Wann AK, Thompson CL, Chapple JP, Knight MM(2013). Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium. Cilia vol. 2, (1)
10.1186/2046-2530-2-17
https://qmro.qmul.ac.uk/xmlui/handle/123456789/9615
Shafat M, Rajakumar K, Syme H, Buchholz N, Knight MM(2013). Stent encrustation in feline and human artificial urine: does the low molecular weight composition account for the difference?. Urolithiasis vol. 41, (6) 481-486.
10.1007/s00240-013-0608-1
Hernandez-Hernandez V, Pravincumar P, Diaz-Font A, May-Simera H, Jenkins D, Knight M, Beales PL(2013). Bardet-Biedl syndrome proteins control the cilia length through regulation of actin polymerization. HUMAN MOLECULAR GENETICS vol. 22, (19) 3858-3868.
10.1093/hmg/ddt241
https://qmro.qmul.ac.uk/xmlui/handle/123456789/9591
Knight MM (2013). THE ROLE OF PRIMARY CILIA IN CARTILAGE HEALTH AND DISEASE. OSTEOARTHRITIS AND CARTILAGE. vol. 21, S2-S2.
10.1016/j.joca.2013.02.013
https://qmro.qmul.ac.uk/xmlui/handle/123456789/9633
Irianto J, Swift J, Martins RP, McPhail GD, Knight MM, Discher DE, Lee DA(2013). Osmotic challenge drives rapid and reversible chromatin condensation in chondrocytes. Biophys J vol. 104, (4) 759-769.
10.1016/j.bpj.2013.01.006
Hosny NA, Song M, Connelly JT, Ameer-Beg S, Knight MM, Wheeler AP(2013). Correction: Super-Resolution Imaging Strategies for Cell Biologists Using a Spinning Disk Microscope. PLoS One vol. 8, (12)
10.1371/annotation/d96769fb-4e7d-4f47-98cf-443447c1471e
Hosny NA, Song M, Knight MM, Wheeler AP(2013). Super-resolution imaging strategies for Cell Biologists using a spinning disk microscope. MOLECULAR BIOLOGY OF THE CELL vol. 24,
Hosny NA, Song M, Connelly JT, Ameer-Beg S, Knight MM, Wheeler AP(2013). Super-resolution imaging strategies for cell biologists using a spinning disk microscope. PLoS One vol. 8, (10)
10.1371/journal.pone.0074604
https://qmro.qmul.ac.uk/xmlui/handle/123456789/9628
Prodromou NV, Thompson CL, Osborn DPS, Cogger KF, Ashworth R, Knight MM, Beales PL, Chapple JP(2012). Heat shock induces rapid resorption of primary cilia. Journal of Cell Science vol. 125, (18) 4297-4305.
10.1242/jcs.100545
Wheeler APS, Morad S, Buchholz N, Knight MM(2012). The Shape of the Urine Stream - From Biophysics to Diagnostics. PLoS ONE vol. 7, (10)
10.1371/journal.pone.0047133
https://qmro.qmul.ac.uk/xmlui/handle/123456789/4743
Chen J, Irianto J, Inamdar S, Pravincumar P, Lee DA, Bader DL, Knight MM(2012). Cell mechanics, structure, and function are regulated by the stiffness of the three-dimensional microenvironment. Biophysical Journal vol. 103, (6) 1188-1197.
10.1016/j.bpj.2012.07.054
Pravincumar P, Bader DL, Knight MM(2012). Viscoelastic Cell Mechanics and Actin Remodelling Are Dependent on the Rate of Applied Pressure. PLoS ONE vol. 7, (9)
10.1371/journal.pone.0043938
https://qmro.qmul.ac.uk/xmlui/handle/123456789/5346
Wann AKT, Knight MM(2012). Primary cilia elongation in response to interleukin-1 mediates the inflammatory response. Cellular and Molecular Life Sciences vol. 69, (17) 2967-2977.
10.1007/s00018-012-0980-y
https://qmro.qmul.ac.uk/xmlui/handle/123456789/9627
Bonzani IC, Campbell JJ, Knight MM, Williams A, Lee DA, Bader DL, Stevens MM(2012). Dynamic compressive strain influences chondrogenic gene expression in human periosteal cells: A case study. Journal of the Mechanical Behavior of Biomedical Materials vol. 11, 72-81.
10.1016/j.jmbbm.2011.06.015
Wann AKT, Zuo N, Haycraft CJ, Jensen CG, Poole CA, McGlashan SR, Knight MM(2012). Primary cilia mediate mechanotransduction through control of ATP-induced Ca<sup>2+</sup> signaling in compressed chondrocytes. FASEB Journal vol. 26, (4) 1663-1671.
10.1096/fj.11-193649
Maeda E, Ye S, Wang W, Bader DL, Knight MM, Lee DA(2012). Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading. Biomechanics and Modeling in Mechanobiology vol. 11, (3-4) 439-447.
10.1007/s10237-011-0323-1
Gladman SJ, Huang W, Lim SN, Dyall SC, Boddy S, Kang JX, Knight MM, Priestley JV et al.(2012). Improved outcome after peripheral nerve injury in mice with increased levels of endogenous Omega-3 polyunsaturated fatty acids. Journal of Neuroscience vol. 32, (2) 563-571.
10.1523/JNEUROSCI.3371-11.2012
Hosny NA, Lee DA, Knight MM(2012). Single photon counting fluorescence lifetime detection of pericellular oxygen concentrations. Journal of Biomedical Optics vol. 17, (1)
10.1117/1.JBO.17.1.016007
Wann AKT, Thompson C, Knight MM(2012). The role of the primary cilium in chondrocyte response to mechanical loading. Mechanically Gated Channels and their Regulation,
Gladman S, Lim SN, Dyall S, Knight MM, Priestley JV, Michael-Titus AT(2011). Omega-3 fatty acids and acute neurological trauma: A perspective on clinical translation. OCL - Oleagineux Corps Gras Lipides vol. 18, (6) 317-323.
10.1684/ocl.2011.0421
Maeda E, Ye S, Wang W, Bader DL, Knight MM, Lee DA(2011). Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading. Biomechanics and Modeling in Mechanobiology1-9.
10.1007/s10237-011-0323-1
Lee DA, Knight MM, Campbell JJ, Bader DL(2011). Stem cell mechanobiology. Journal of Cellular Biochemistry vol. 112, (1) 1-9.
10.1002/jcb.22758
Gladman SJ, Ward RE, Michael-Titus AT, Knight MM, Priestley JV(2010). The effect of mechanical strain or hypoxia on cell death in subpopulations of rat dorsal root ganglion neurons in vitro. Neuroscience vol. 171, (2) 577-587.
10.1016/j.neuroscience.2010.07.009
Vaughan NM, Grainger J, Bader DL, Knight MM(2010). The potential of pulsed low intensity ultrasound to stimulate chondrocytes matrix synthesis in agarose and monolayer cultures. Medical and Biological Engineering and Computing vol. 48, (12) 1215-1222.
10.1007/s11517-010-0681-3
https://qmro.qmul.ac.uk/xmlui/handle/123456789/9631
Wann AKT, Mistry J, Blain EJ, Michael-Titus AT, Knight MM(2010). Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1β-mediated cartilage degradation. Arthritis Research and Therapy vol. 12, (6)
10.1186/ar3183
https://qmro.qmul.ac.uk/xmlui/handle/123456789/202
Heywood HK, Knight MM, Lee DA(2010). Both superficial and deep zone articular chondrocyte subpopulations exhibit the crabtree effect but have different basal oxygen consumption rates. Journal of Cellular Physiology vol. 223, (3) 630-639.
10.1002/jcp.22061
Garcia M, Knight MM(2010). Cyclic loading opens hemichannels to release ATP as part of a chondrocyte mechanotransduction pathway. Journal of Orthopaedic Research vol. 28, (4) 510-515.
10.1002/jor.21025
Bader DL, Knight MM(2010). Measuring the biomechanical properties of cartilage cells. 106-136.
10.1533/9781845697792.1.106
McGlashan SR, Knight MM, Chowdhury TT, Joshi P, Jensen CG, Kennedy S, Poole CA(2010). Mechanical loading modulates chondrocyte primary cilia incidence and length. Cell Biology International vol. 34, (5) 441-446.
10.1042/CBI20090094
Knight MM, Mcglashan SR, Garcia M, Jensen CG, Poole CA(2009). Articular chondrocytes express connexin 43 hemichannels and P2 receptors - A putative mechanoreceptor complex involving the primary cilium?. Journal of Anatomy vol. 214, (2) 275-283.
10.1111/j.1469-7580.2008.01021.x
Bader DL, Knight MM(2008). Biomechanical analysis of structural deformation in living cells. Medical and Biological Engineering and Computing vol. 46, (10) 951-963.
10.1007/s11517-008-0381-4
Campbell JJ, Knight MM(2007). An improved confocal FRAP technique for the measurement of long-term actin dynamics in individual stress fibers. Microscopy Research and Technique vol. 70, (12) 1034-1040.
10.1002/jemt.20513
Campbell JJ, Blain EJ, Chowdhury TT, Knight MM(2007). Loading alters actin dynamics and up-regulates cofilin gene expression in chondrocytes. Biochemical and Biophysical Research Communications vol. 361, (2) 329-334.
10.1016/j.bbrc.2007.06.185
KNIGHT MM, Chowdhury TT, Campbell JJ, Blain EJ(2007). Loading alters actin dynamics and up-regulates cofilin gene expression in chondrocytes. Biochemical and Biophysical Research Communications vol. 361, (21) 329-334.
10.1016/j.bbrc.2007.06.185
Chowdhury TT, Knight MM(2006). Purinergic pathway suppresses the release of NO and stimulates proteoglycan synthesis in chondrocyte/agarose constructs subjected to dynamic compression. Journal of Cellular Physiology vol. 209, (3) 845-853.
10.1002/jcp.20768
Pingguan-Murphy B, El-Azzeh M, Bader DL, Knight MM(2006). Cyclic compression of chondrocytes modulates a purinergic calcium signalling pathway in a strain rate- and frequency-dependent manner. Journal of Cellular Physiology vol. 209, (2) 389-397.
10.1002/jcp.20747
Bomzon Z, Knight MM, Bader DL, Kimmel E(2006). Mitochondrial dynamics in chondrocytes and their connection to the mechanical properties of the cytoplasm. Journal of Biomechanical Engineering vol. 128, (5) 674-679.
10.1115/1.2246239
Hakimi O, Knight DP, Knight MM, Grahn MF, Vadgama P(2006). Ultrastructure of insect and spider cocoon silks. Biomacromolecules vol. 7, (10) 2901-2908.
10.1021/bm060528h
Ohashi T, Hagiwara M, Bader DL, Knight MM(2006). Intracellular mechanics and mechanotransduction associated with chondrocyte deformation during pipette aspiration. Biorheology vol. 43, (3-4) 201-214.
Knight MM, Bomzon Z, Kimmel E, Sharma AM, Lee DA, Bader DL(2006). Chondrocyte deformation induces mitochondrial distortion and heterogeneous intracellular strain fields. Biomechanics and Modeling in Mechanobiology vol. 5, (2-3) 180-191.
10.1007/s10237-006-0020-7
Knight MM, Toyoda T, Lee DA, Bader DL(2006). Mechanical compression and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose. Journal of Biomechanics vol. 39, (8) 1547-1551.
10.1016/j.jbiomech.2005.04.006
Pingguan-Murphy B, Lee DA, Bader DL, Knight MM(2005). Activation of chondrocytes calcium signalling by dynamic compression is independent of number of cycles. Archives of Biochemistry and Biophysics vol. 444, (1) 45-51.
10.1016/j.abb.2005.09.015
Sawae Y, Shelton JC, Bader DL, Knight MM(2004). Confocal analysis of local and cellular strains in chondrocyte-agarose constructs subjected to mechanical shear. Ann Biomed Eng vol. 32, (6) 860-870.
10.1023/b:abme.0000030261.38396.c0
Holloway I, Kayser M, Lee DA, Bader DL, Bentley G, Knight MM(2004). Increased presence of cells with multiple elongated processes in osteoarthritic femoral head cartilage. Osteoarthritis Cartilage vol. 12, (1) 17-24.
10.1016/j.joca.2003.09.001
Lee DA, Knight MM(2004). Mechanical loading of chondrocytes embedded in 3D constructs: in vitro methods for assessment of morphological and metabolic response to compressive strain. Methods in molecular medicine vol. 100, 307-324.
10.1385/1-59259-810-2:307
Knight MM, Roberts SR, Lee DA, Bader DL(2003). Live cell imaging using confocal microscopy induces intracellular calcium transients and cell death. Am J Physiol Cell Physiol vol. 284, (4) C1083-C1089.
10.1152/ajpcell.00276.2002
Bader DL, SHELTON JC, Knight MM, Sawae Y(2003). Confocal Analysis of Local and Cellular Strains in Chondrocyte - Agarose Constructs Subjected to Shear. J Biochemical Engineering ASME
10.1023/B:ABME.0000030261.38396.c0
Knight MM, Roberts SR, Lee DA, Bader DL (2002). Light-induced calcium signalling in chondrocytes. European Cells and Materials. vol. 4, 7-8.
Knight MM, Toyoda T, Bader DL, Lee DA (2002). Mechanical strain and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose. Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products.
Holloway I, Knight MM, Lee DA, Bader DL, Bentley G (2002). Changes in cell morphology and cytoskeletal organisation in osteoarthric cartilage. European Cells and Materials. vol. 4, 52-53.
Bader DL, Ohashi T, Knight MM, Lee DA, Sato M (2002). Deformation properties of articular chondrocytes: A critique of three separate techniques. Biorheology. vol. 39, 69-78.
Knight MM, Van De Breevaart Bravenboer J, Lee DA, Van Osch GJVM, Weinans H, Bader DL(2002). Cell and nucleus deformation in compressed chondrocyte-alginate constructs: Temporal changes and calculation of cell modulus. Biochimica et Biophysica Acta - General Subjects vol. 1570, (1) 1-8.
10.1016/S0304-4165(02)00144-7
Holloway I, Knight MM, LEE DA, Bader DL, Bentley G (2002). Characterisation of cell morphology, cytoskeletal organization and apoptosis in human osteoarthritic cartilage. Trans. Orthop. Res. Soc. Conference: 48th Annual Meeting of the Orthopaedic Research Society vol. 27,
Knight MM, Roberts SR, LEE DA, Bader DL (2002). Light-induced calcium signalling in chondrocytes. Eur. Cells Materials. Conference: TCES 2002 Annual meeting of the UK Tissue and Cell Engineering Society (University of Glasgow, Scotland) from: 19/09/2002 to: 20/09/2002, vol. 4, 7-8.
Knight MM, Toyoda T, LEE DA, Bader DL (2002). Mechanical strain and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose. Trans. Orthop. Res. Soc.. Conference: 48th Annual Meeting of the Orthopaedic Research Society vol. 27, 35-35.
Knight MM, Ross JM, Sherwin AF, Lee DA, Bader DL, Poole CA(2001). Chondrocyte deformation within mechanically and enzymatically extracted chondrons compressed in agarose. Biochim Biophys Acta vol. 1526, (2) 141-146.
10.1016/s0304-4165(01)00118-0
Knight MM, Idowu BD, Lee DA, Bader DL(2001). Temporal changes in cytoskeletal organisation within isolated chondrocytes quantified using a novel image analysis technique. Med Biol Eng Comput vol. 39, (3) 397-404.
10.1007/BF02345297
Roberts SR, Knight MM, Lee DA, Bader DL(2001). Mechanical compression influences intracellular Ca<sup>2+</sup> signaling in chondrocytes seeded in agarose constructs. Journal of Applied Physiology vol. 90, (4) 1385-1391.
10.1152/jappl.2001.90.4.1385
Bouten CVC, Knight MM, Lee DA, Bader DL(2001). Compressive deformation and damage of muscle cell subpopulations in a model system. ANN BIOMED ENG vol. 29, (2) 153-163.
10.1114/1.1349698
LEE DA, Idowu BD, Knight MM, Bader DL (2001). Mechanical compression influences cytoskeletal oragnisation within chondrocytes seeded in agarose constructs. Trans. Orthop. Res. Soc.. Conference: 47th Annual Meeting, Orthopaedic Research Society (San Francisco, California) from: 25/02/2001 to: 28/02/2001, vol. 26, 263-263.
Knight MM, van de Breevaart Brevenboer J, van Osch G, Weinans H, LEE DA, Bader DL (2001). Temporal changes in cell and nucleus deformation in isolated chondrocytes compressed in alginate scaffolds. Trans. Orthop. Res. Soc.. Conference: 47th Annual Meeting, Orthopaedic Research Society (San Francisco, California) from: 25/02/2001 to: 28/02/2001, vol. 26, 611-611.
Knight MM, Van De Breevaart Bravenboer J, Bader DL, Lee DA (2000). Compression induced cell and nucleus deformation in chondrocyte-alginate constructs. Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling.
Roberts SR, Knight MM, Lee DA, Bader DL (2000). Intracellular - CA2+ signalling in compressed chondrocyte agarose constructs. Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling.
Idowu BD, Knight MM, Bader DL, Lee DA(2000). Confocal analysis of cytoskeletal organisation within isolated chondrocyte sub-populations cultured in agarose. Histochemical Journal vol. 32, (3) 165-174.
10.1023/A:1004095207330
Roberts SR, Knight MM, Lee DA, Bader DL (2000). Intracellular calcium signalling in compressed chondrocyte agarose constructs. J PHYSIOL-LONDON. vol. 523, 12P-12P.
Knight DP, KNIGHT MM, Vollrath F(2000). Beta transition and stress-induced phase separation in the spinning of spider dragline silk. International Journal of Biological Macromolecules vol. 27, (3) 205-210.
10.1016/s0141-8130(00)00124-0
Lee DA, Knight MM, Bolton JF, Idowu BD, Kayser MV, Bader DL(2000). Chondrocyte deformation within compressed agarose constructs at the cellular and sub-cellular levels. J Biomech vol. 33, (1) 81-95.
10.1016/s0021-9290(99)00160-8
Hing K, Knight M (1998). Prize-winning peeks at the microscopic world.
Knight MM, Ghori SA, Lee DA, Bader DL(1998). Measurement of the deformation of isolated chondrocytes in agarose subjected to cyclic compression. Medical Engineering and Physics vol. 20, (9) 684-688.
10.1016/S1350-4533(98)00080-0
Lee DA, Noguchi T, Knight MM, O'Donnell L, Bentley G, Bader DL(1998). Response of chondrocyte subpopulations cultured within unloaded and loaded agarose. J Orthop Res vol. 16, (6) 726-733.
10.1002/jor.1100160615
Knight MM, Lee DA, Bader DL(1998). The influence of elaborated pericellular matrix on the deformation of isolated articular chondrocytes cultured in agarose. Biochim Biophys Acta vol. 1405, (1-3) 67-77.
10.1016/s0167-4889(98)00102-5
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