Publications: Prof Martin Knight
Thompson CL, Fu S, Knight MM, Thorpe SD(2020).
Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models. Frontiers in Bioengineering and Biotechnology
vol. 8,
Fu S, Meng H, Freer F, Kwon J, Shelton JC, Knight MM(2020).
Sub-toxic levels of Co<sup>2+</sup> are anti-inflammatory and protect cartilage from degradation caused by IL-1β. Clinical Biomechanics
vol. 79,
Zhang J, Guo Q, Li X, Li C, Wu K, Abrahams I, Yan H, Knight MM et al.(2020).
Solution-Processed Epitaxial Growth of Arbitrary Surface Nanopatterns on Hybrid Perovskite Monocrystalline Thin Films. ACS nano
vol. 14,
(9)
11029-11039.
Torres-Pérez JV, Naeem H, Thompson CL, Knight MM, Novak P(2020).
Nanoscale mapping reveals functional differences in ion channels populating the membrane of primary cilia. Cellular Physiology and Biochemistry
vol. 54,
(1)
15-26.
Walker RV, Keynton JL, Grimes DT, Sreekumar V, Williams DJ, Esapa C, Wu D, Knight MM et al.(2019).
Ciliary exclusion of Polycystin-2 promotes kidney cystogenesis in an autosomal dominant polycystic kidney disease model. Nature Communications
vol. 10,
(1)
Delaine-Smith R, Wright N, Hanley CJ, Hanwell R, Bhome R, Bullock M, Drifka CR, Eliceiri KW et al. (2019).
Transglutaminase-2 mediates stromal biomechanics in colorectal cancer. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY.
vol. 100,
A15-A16.
Inamdar SR, Barbieri E, Terrill NJ, Knight MM, Gupta HS(2019).
Proteoglycan degradation mimics static compression by altering the natural gradients in fibrillar organisation in cartilage. Acta Biomaterialia
vol. 97,
437-450.
Fu S, Thompson CL, Ali A, Wang W, Chapple JP, Mitchison HM, Beales PL, Wann AKT et al.(2019).
Mechanical loading inhibits cartilage inflammatory signalling via an HDAC6 and IFT-dependent mechanism regulating primary cilia elongation. Osteoarthritis and Cartilage
vol. 27,
(7)
1064-1074.
Delaine-Smith R, Wright N, Hanley C, Hanwell R, Bhome R, Bullock M, Drifka C, Eliceiri K et al.(2019).
Transglutaminase-2 Mediates the Biomechanical Properties of the Colorectal Cancer Tissue Microenvironment that Contribute to Disease Progression. Cancers
Harris C, THORPE SD, Rushwan S, Wang W, THOMPSON C, Peacock J, KNIGHT M, Gooptu B et al.(2019).
An in vitro investigation of the inflammatory response to the strain amplitudes which occur during high frequency oscillation ventilation and conventional mechanical ventilation. Journal of Biomechanics
O¿Toole SM, Watson DS, Novoselova TV, Romano LEL, King PJ, Bradshaw TY, Thompson CL, Knight MM et al.(2019).
Oncometabolite induced primary cilia loss in pheochromocytoma. Endocrine-Related Cancer
vol. 26,
(1)
165-180.
Pearce OMT, Nichols S, Delaine-Smith R, Jones RR, Maniati E, Rootizalab R, Mackerodt J, Knight MM et al. (2018).
Investigating drivers of the tumour matrisome, and their role in disease progression. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY.
vol. 99,
A49-A49.
Rowson DT, Shelton JC, Screen HRC, Knight MM(2018).
Mechanical loading induces primary cilia disassembly in tendon cells via TGFβ and HDAC6. Scientific Reports
vol. 8,
(1)
Xu J, Nyga A, Li W, Zhang X, Gavara N, Knight MM, Shelton JC(2018).
Cobalt ions stimulate a fibrotic response through matrix remodelling, fibroblast contraction and release of pro-fibrotic signals from macrophages. European Cells and Materials
vol. 36,
142-155.
Kenny FN, Drymoussi Z, Delaine-Smith R, Kao AP, Laly AC, Knight MM, Philpott MP, Connelly JT(2018).
Tissue stiffening promotes keratinocyte proliferation through activation of epidermal growth factor signaling. Journal of Cell Science
vol. 131,
(10)
Xu J, Yang J, Nyga A, Ehteramyan M, Moraga A, Wu Y, Zeng L, Knight MM et al.(2018).
Cobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated down-regulation of RhoA expression. Acta Biomater
vol. 72,
434-446.
Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D et al.(2017).
Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers. Cancer Discov
Gambassi S, Geminiani M, Thorpe SD, Bernardini G, Millucci L, Braconi D, Orlandini M, Thompson CL et al.(2017).
Smoothened-antagonists reverse homogentisic acid-induced alterations of Hedgehog signaling and primary cilium length in alkaptonuria. Journal of Cellular Physiology
vol. 232,
(11)
3103-3111.
Thompson CL, Plant JC, Wann AK, Bishop CL, Novak P, Mitchison HM, Beales PL, Chapple JP et al.(2017).
Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling. Eur Cell Mater
vol. 34,
128-141.
Inamdar SR, Knight DP, Terrill NJ, Karunaratne A, Cacho-Nerin F, Knight MM, Gupta HS(2017).
The Secret Life of Collagen: Temporal Changes in Nanoscale Fibrillar Pre-Strain and Molecular Organization During Physiological Loading of Cartilage. ACS Nano
Zhang J, Dalbay MT, Luo X, Vrij E, Barbieri D, Moroni L, de Bruijn JD, van Blitterswijk CA et al.(2017).
Topography of calcium phosphate ceramics regulates primary cilia length and TGF receptor recruitment associated with osteogenesis. Acta Biomater
vol. 57,
487-497.
Balkwill FR, Pearce OM, Delaine-Smith R, Maniati E, Nichols S, Wang J, Bessant C, Knight M (2017).
Abstract 5558: Deconstruction of a human tumor microenvironment. 5558-5558.
Harris C, Rushwan S, Wang W, Thorpe S, Thompson C, Peacock J, Knight M, Gooptu B et al. (2017).
P07 Interleukin response to cyclical mechanical stretch with models of different neonatal ventilation modes. Archives of Disease in Childhood.
vol. 102,
THORPE SD, Gambassi S, Thompson CL, Chandrakumar C, Santucci A, Knight MM(2017).
Reduced Primary Cilia Length and Altered Arl13b Expression Are Associated with Deregulated Chondrocyte Hedgehog Signalling in Alkaptonuria. Journal of Cellular Physiology
Rowson DT, Knight MM, Screen HRC (2017).
Cyclic loading leads to primary cilia disassembly in human tenocytes. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY.
vol. 98,
A6-A6.
Thompson CL, Chapple JP, Beales PL, Mitchison HM, Ramachandran M, Knight MM (2017).
Polycystins are required for primary cilia-mediated mechanotransduction in chondrocytes. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY.
vol. 98,
A14-A14.
Knight MM (2017).
Primary cilia mechanobiology. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY.
vol. 98,
A3-A4.
Gooptu B, Rushwan S, Wang W, Harris C, Thorpe S, Knight M, Sethi T (2017).
A Cd98hc-Dependent Mechanism Mediates Pro-Inflammatory Cytokine Release In Cell And Animal Models Of Lung Injury. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
vol. 195,
Delaine-Smith RM, Burney S, Balkwill FR, Knight MM(2016).
Experimental validation of a flat punch indentation methodology calibrated against unconfined compression tests for determination of soft tissue biomechanics. Journal of the Mechanical Behavior of Biomedical Materials
vol. 60,
401-415.
Sliogeryte K, Botto L, Lee DA, Knight MM(2016).
Chondrocyte dedifferentiation increases cell stiffness by strengthening membrane-actin adhesion. Osteoarthritis and Cartilage
vol. 24,
(5)
912-920.
Thorpe SD, Gambassi S, Patel R, Santucci A, Knight MM (2016).
Changes in chondrocyte primary cilia structure and function are associated with altered mechanoregulation in Alkaptonuria. Osteoarthritis and Cartilage.
vol. 24,
s174-s175.
Kelly T-AN, Thompson CL, Tan E, Wann AK, Thorpe SD, Chapple JP, Hung CT, Knight MM (2016).
Chondrocyte dedifferentiation down regulates mechano-responsiveness and hedgehog signalling associated with changes in primary cilia structure. Osteoarthritis and Cartilage.
Conference: World Congress of the Osteoarthritis-Research-Society-International (OARSI) on Osteoarthritis
from: 31/03/2016
to: 03/04/2016,
vol. 24,
S342-S343.
Rowson D, Knight MM, Screen HRC(2016).
Zonal variation in primary cilia elongation correlates with localized biomechanical degradation in stress deprived tendon. J Orthop Res
vol. 34,
(12)
2146-2153.
Wang Z, Wann AKT, Thompson CL, Hassen A, Wang W, Knight MM(2016).
IFT88 influences chondrocyte actin organization and biomechanics. Osteoarthritis and cartilage
vol. 24,
(3)
544-554.
Thompson CL, Wiles A, Poole CA, Knight MM(2016).
Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling. FASEB Journal
vol. 30,
(2)
716-726.
Sliogeryte K, Thorpe SD, Wang Z, Thompson CL, Gavara N, Knight MM(2016).
Differential effects of LifeAct-GFP and actin-GFP on cell mechanics assessed using micropipette aspiration. Journal of Biomechanics
vol. 49,
(2)
310-317.
Thompson CL, Patel R, Kelly T-AN, Wann AKT, Hung CT, Chapple JP, Knight MM(2015).
Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β. Arthritis Research & Therapy
vol. 17,
(1)
Tan AR, VandenBerg CD, Attur M, Abramson SB, Knight MM, Bulinski JC, Ateshian GA, Cook JL et al.(2015).
Cytokine preconditioning of engineered cartilage provides protection against interleukin-1 insult. Arthritis Res Ther
vol. 17,
361-361.
Thompson CL, Poole CA, Knight MM(2015).
Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling. The FASEB Journal
vol. 100,
(4)
A39-A40.
KNIGHT MM, Thompson CL, Yasmin H, Varone A, Wiles A, Poole CA(2015).
Lithium chloride prevents interleukin- 1β induced cartilage degradation and loss of mechanical properties. Journal of Orthopaedic Research
Dalbay MT, Thorpe SD, Connelly JT, Chapple JP, Knight MM(2015).
Adipogenic differentiation of hMSCs is mediated by recruitment of IGF-1r onto the primary cilium associated with cilia elongation. Stem Cells
vol. 33,
(6)
1952-1961.
Chen J, Bader DL, Lee DA, Knight MM(2015).
FINITE ELEMENT ANALYSIS of MECHANICAL DEFORMATION of CHONDROCYTE to 2D SUBSTRATE and 3D SCAFFOLD. Journal of Mechanics in Medicine and Biology
vol. 15,
(5)
Wang Z, Irianto J, Kazun S, Wang W, Knight MM(2015).
The rate of hypo-osmotic challenge influences regulatory volume decrease (RVD) and mechanical properties of articular chondrocytes. Osteoarthritis and Cartilage
vol. 23,
(2)
289-299.
Rowson D, Knight M, Screen H(2014).
89 Primary Cilia In Tenocytes From The Inter-fascicular Matrix And The Fascicular Matrix. British Journal of Sports Medicine
vol. 48,
(Suppl 2)
a58-a59.
Wann AKT, Chapple JP, Knight MM(2014).
The primary cilium influences interleukin-1β-induced NFκB signalling by regulating IKK activity. Cell Signal
vol. 26,
(8)
1735-1742.
Shaheen T, Edirisinghe T, Gabriel M, Bourdoumis A, Buchholz N, Knight M(2014).
In vitro encrustation of a semi-permanent polymer-covered nitinol ureter stent: an artificial urine model. UROLITHIASIS
vol. 42,
(3)
203-207.
Thompson CL, Chapple JP, Knight MM(2014).
Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes. Osteoarthritis Cartilage
vol. 22,
(3)
490-498.
Irianto J, Lee DA, Knight MM(2014).
Quantification of chromatin condensation level by image processing. Med Eng Phys
vol. 36,
(3)
412-417.
Irianto J, Ramaswamy G, Serra R, Knight MM(2014).
Depletion of chondrocyte primary cilia reduces the compressive modulus of articular cartilage. J Biomech
vol. 47,
(2)
579-582.
Sliogeryte K, Thorpe SD, Lee DA, Botto L, Knight MM(2014).
Stem cell differentiation increases membrane-actin adhesion regulating cell blebability, migration and mechanics. Scientific Reports
vol. 4,
McMurray RJ, Wann AKT, Thompson CL, Connelly JT, Knight MM(2013).
Surface topography regulates wnt signaling through control of primary cilia structure in mesenchymal stem cells. Sci Rep
vol. 3,
Wann AK, Thompson CL, Chapple JP, Knight MM(2013).
Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium. Cilia
vol. 2,
(1)
Shafat M, Rajakumar K, Syme H, Buchholz N, Knight MM(2013).
Stent encrustation in feline and human artificial urine: does the low molecular weight composition account for the difference?. Urolithiasis
vol. 41,
(6)
481-486.
Hernandez-Hernandez V, Pravincumar P, Diaz-Font A, May-Simera H, Jenkins D, Knight M, Beales PL(2013).
Bardet-Biedl syndrome proteins control the cilia length through regulation of actin polymerization. HUMAN MOLECULAR GENETICS
vol. 22,
(19)
3858-3868.
Knight MM (2013).
THE ROLE OF PRIMARY CILIA IN CARTILAGE HEALTH AND DISEASE. OSTEOARTHRITIS AND CARTILAGE.
vol. 21,
S2-S2.
Irianto J, Swift J, Martins RP, McPhail GD, Knight MM, Discher DE, Lee DA(2013).
Osmotic challenge drives rapid and reversible chromatin condensation in chondrocytes. Biophys J
vol. 104,
(4)
759-769.
Hosny NA, Song M, Connelly JT, Ameer-Beg S, Knight MM, Wheeler AP(2013).
Correction: Super-Resolution Imaging Strategies for Cell Biologists Using a Spinning Disk Microscope. PLoS One
vol. 8,
(12)
Hosny NA, Song M, Knight MM, Wheeler AP(2013).
Super-resolution imaging strategies for Cell Biologists using a spinning disk microscope. MOLECULAR BIOLOGY OF THE CELL
vol. 24,
Hosny NA, Song M, Connelly JT, Ameer-Beg S, Knight MM, Wheeler AP(2013).
Super-resolution imaging strategies for cell biologists using a spinning disk microscope. PLoS One
vol. 8,
(10)
Prodromou NV, Thompson CL, Osborn DPS, Cogger KF, Ashworth R, Knight MM, Beales PL, Chapple JP(2012).
Heat shock induces rapid resorption of primary cilia. Journal of Cell Science
vol. 125,
(18)
4297-4305.
Wann A, Knight M(2012).
A role for IFT88/the primary cilium in the inflammatory response to interleukin-1. Cilia
vol. 1,
(Suppl 1)
Hernandez V, Pravincumar P, Diaz-Font A, May-Simera H, Jenkins D, Knight M, Beales P(2012).
Bardet-Biedl syndrome proteins control cilia length through regulation of actin polymerisation. Cilia
vol. 1,
(Suppl 1)
Thompson C, Prodromou N, Osborn D, Ashworth R, Knight M, Beales P, Chapple J(2012).
Heat-shock induces rapid resorption of primary cilia. Cilia
vol. 1,
(Suppl 1)
Thompson C, Chapple J, Knight M(2012).
Mechanical strain disrupts primary cilia structure and modulates hedgehog signalling in adult chondrocytes. Cilia
vol. 1,
(Suppl 1)
Wann A, Zuo N, Haycraft C, Jensen C, Poole C, McGlashan S, Knight M(2012).
The primary cilium conducts chondrocyte mechanotransduction. Cilia
vol. 1,
(Suppl 1)
McMurray R, Knight M(2012).
Topographical regulation of primary cilia orientation and length in mesenchymal stem cells. Cilia
vol. 1,
(Suppl 1)
Wheeler APS, Morad S, Buchholz N, Knight MM(2012).
The Shape of the Urine Stream - From Biophysics to Diagnostics. PLoS ONE
vol. 7,
(10)
Chen J, Irianto J, Inamdar S, Pravincumar P, Lee DA, Bader DL, Knight MM(2012).
Cell mechanics, structure, and function are regulated by the stiffness of the three-dimensional microenvironment. Biophysical Journal
vol. 103,
(6)
1188-1197.
Pravincumar P, Bader DL, Knight MM(2012).
Viscoelastic Cell Mechanics and Actin Remodelling Are Dependent on the Rate of Applied Pressure. PLoS ONE
vol. 7,
(9)
Wann AKT, Knight MM(2012).
Primary cilia elongation in response to interleukin-1 mediates the inflammatory response. Cellular and Molecular Life Sciences
vol. 69,
(17)
2967-2977.
Bonzani IC, Campbell JJ, Knight MM, Williams A, Lee DA, Bader DL, Stevens MM(2012).
Dynamic compressive strain influences chondrogenic gene expression in human periosteal cells: A case study. Journal of the Mechanical Behavior of Biomedical Materials
vol. 11,
72-81.
Wann AKT, Zuo N, Haycraft CJ, Jensen CG, Poole CA, McGlashan SR, Knight MM(2012).
Primary cilia mediate mechanotransduction through control of ATP-induced Ca<sup>2+</sup> signaling in compressed chondrocytes. FASEB Journal
vol. 26,
(4)
1663-1671.
Maeda E, Ye S, Wang W, Bader DL, Knight MM, Lee DA(2012).
Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading. Biomechanics and Modeling in Mechanobiology
vol. 11,
(3-4)
439-447.
Gladman SJ, Huang W, Lim SN, Dyall SC, Boddy S, Kang JX, Knight MM, Priestley JV et al.(2012).
Improved outcome after peripheral nerve injury in mice with increased levels of endogenous Omega-3 polyunsaturated fatty acids. Journal of Neuroscience
vol. 32,
(2)
563-571.
Hosny NA, Lee DA, Knight MM(2012).
Single photon counting fluorescence lifetime detection of pericellular oxygen concentrations. Journal of Biomedical Optics
vol. 17,
(1)
Wann AKT, Thompson C, Knight MM(2012).
The role of the primary cilium in chondrocyte response to mechanical loading. Mechanically Gated Channels and their Regulation,
Gladman S, Lim SN, Dyall S, Knight MM, Priestley JV, Michael-Titus AT(2011).
Omega-3 fatty acids and acute neurological trauma: A perspective on clinical translation. OCL - Oleagineux Corps Gras Lipides
vol. 18,
(6)
317-323.
Maeda E, Ye S, Wang W, Bader DL, Knight MM, Lee DA(2011).
Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading. Biomechanics and Modeling in Mechanobiology1-9.
Lee DA, Knight MM, Campbell JJ, Bader DL(2011).
Stem cell mechanobiology. Journal of Cellular Biochemistry
vol. 112,
(1)
1-9.
Gladman SJ, Ward RE, Michael-Titus AT, Knight MM, Priestley JV(2010).
The effect of mechanical strain or hypoxia on cell death in subpopulations of rat dorsal root ganglion neurons in vitro. Neuroscience
vol. 171,
(2)
577-587.
Vaughan NM, Grainger J, Bader DL, Knight MM(2010).
The potential of pulsed low intensity ultrasound to stimulate chondrocytes matrix synthesis in agarose and monolayer cultures. Medical and Biological Engineering and Computing
vol. 48,
(12)
1215-1222.
Wann AKT, Mistry J, Blain EJ, Michael-Titus AT, Knight MM(2010).
Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1β-mediated cartilage degradation. Arthritis Research and Therapy
vol. 12,
(6)
Heywood HK, Knight MM, Lee DA(2010).
Both superficial and deep zone articular chondrocyte subpopulations exhibit the crabtree effect but have different basal oxygen consumption rates. Journal of Cellular Physiology
vol. 223,
(3)
630-639.
Garcia M, Knight MM(2010).
Cyclic loading opens hemichannels to release ATP as part of a chondrocyte mechanotransduction pathway. Journal of Orthopaedic Research
vol. 28,
(4)
510-515.
Bader DL, Knight MM(2010).
4 Measuring the biomechanical properties of cartilage cells. Regenerative Medicine and Biomaterials for the Repair of Connective Tissues,
Archer C, Ralphs J, Säämänen A-M, Arokoski JPA, Jurvelin JS, Kiviranta I, Hinz B, Hunziker EB et al.(2010).
Contributor contact details. Regenerative Medicine and Biomaterials for the Repair of Connective Tissues,
Bader DL, Knight MM(2010).
Measuring the biomechanical properties of cartilage cells. 106-136.
McGlashan SR, Knight MM, Chowdhury TT, Joshi P, Jensen CG, Kennedy S, Poole CA(2010).
Mechanical loading modulates chondrocyte primary cilia incidence and length. Cell Biology International
vol. 34,
(5)
441-446.
Knight MM, Mcglashan SR, Garcia M, Jensen CG, Poole CA(2009).
Articular chondrocytes express connexin 43 hemichannels and P2 receptors - A putative mechanoreceptor complex involving the primary cilium?. Journal of Anatomy
vol. 214,
(2)
275-283.
Bader DL, Knight MM(2008).
Biomechanical analysis of structural deformation in living cells. Medical and Biological Engineering and Computing
vol. 46,
(10)
951-963.
Campbell JJ, Knight MM(2007).
An improved confocal FRAP technique for the measurement of long-term actin dynamics in individual stress fibers. Microscopy Research and Technique
vol. 70,
(12)
1034-1040.
Campbell JJ, Blain EJ, Chowdhury TT, Knight MM(2007).
Loading alters actin dynamics and up-regulates cofilin gene expression in chondrocytes. Biochemical and Biophysical Research Communications
vol. 361,
(2)
329-334.
KNIGHT MM, Chowdhury TT, Campbell JJ, Blain EJ(2007).
Loading alters actin dynamics and up-regulates cofilin gene expression in chondrocytes. Biochemical and Biophysical Research Communications
vol. 361,
(21)
329-334.
Chowdhury TT, Knight MM(2006).
Purinergic pathway suppresses the release of NO and stimulates proteoglycan synthesis in chondrocyte/agarose constructs subjected to dynamic compression. Journal of Cellular Physiology
vol. 209,
(3)
845-853.
Pingguan-Murphy B, El-Azzeh M, Bader DL, Knight MM(2006).
Cyclic compression of chondrocytes modulates a purinergic calcium signalling pathway in a strain rate- and frequency-dependent manner. Journal of Cellular Physiology
vol. 209,
(2)
389-397.
Bomzon Z, Knight MM, Bader DL, Kimmel E(2006).
Mitochondrial dynamics in chondrocytes and their connection to the mechanical properties of the cytoplasm. Journal of Biomechanical Engineering
vol. 128,
(5)
674-679.
Hakimi O, Knight DP, Knight MM, Grahn MF, Vadgama P(2006).
Ultrastructure of insect and spider cocoon silks. Biomacromolecules
vol. 7,
(10)
2901-2908.
Ohashi T, Hagiwara M, Bader DL, Knight MM(2006).
Intracellular mechanics and mechanotransduction associated with chondrocyte deformation during pipette aspiration. Biorheology
vol. 43,
(3-4)
201-214.
Knight MM, Bomzon Z, Kimmel E, Sharma AM, Lee DA, Bader DL(2006).
Chondrocyte deformation induces mitochondrial distortion and heterogeneous intracellular strain fields. Biomechanics and Modeling in Mechanobiology
vol. 5,
(2-3)
180-191.
Knight MM, Toyoda T, Lee DA, Bader DL(2006).
Mechanical compression and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose. Journal of Biomechanics
vol. 39,
(8)
1547-1551.
Pingguan-Murphy B, Lee DA, Bader DL, Knight MM(2005).
Activation of chondrocytes calcium signalling by dynamic compression is independent of number of cycles. Archives of Biochemistry and Biophysics
vol. 444,
(1)
45-51.
Lee DA, Knight MM(2004).
Mechanical Loading of Chondrocytes Embedded in 3D Constructs. Cartilage and Osteoarthritis,
vol. 100,
Sawae Y, Shelton JC, Bader DL, Knight MM(2004).
Confocal analysis of local and cellular strains in chondrocyte-agarose constructs subjected to mechanical shear. Ann Biomed Eng
vol. 32,
(6)
860-870.
Holloway I, Kayser M, Lee DA, Bader DL, Bentley G, Knight MM(2004).
Increased presence of cells with multiple elongated processes in osteoarthritic femoral head cartilage. Osteoarthritis Cartilage
vol. 12,
(1)
17-24.
Lee DA, Knight MM(2004).
Mechanical loading of chondrocytes embedded in 3D constructs: in vitro methods for assessment of morphological and metabolic response to compressive strain. Methods in molecular medicine
vol. 100,
307-324.
Knight MM, Roberts SR, Lee DA, Bader DL(2003).
Live cell imaging using confocal microscopy induces intracellular calcium transients and cell death. Am J Physiol Cell Physiol
vol. 284,
(4)
C1083-C1089.
Bader DL, SHELTON JC, Knight MM, Sawae Y(2003).
Confocal Analysis of Local and Cellular Strains in Chondrocyte - Agarose Constructs Subjected to Shear. J Biochemical Engineering ASME
Knight MM, Roberts SR, Lee DA, Bader DL (2002).
Light-induced calcium signalling in chondrocytes. European Cells and Materials.
vol. 4,
7-8.
Knight MM, Toyoda T, Bader DL, Lee DA (2002).
Mechanical strain and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose. Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products.
Holloway I, Knight MM, Lee DA, Bader DL, Bentley G (2002).
Changes in cell morphology and cytoskeletal organisation in osteoarthric cartilage. European Cells and Materials.
vol. 4,
52-53.
Bader DL, Ohashi T, Knight MM, Lee DA, Sato M (2002).
Deformation properties of articular chondrocytes: A critique of three separate techniques. Biorheology.
vol. 39,
69-78.
Knight MM, Van De Breevaart Bravenboer J, Lee DA, Van Osch GJVM, Weinans H, Bader DL(2002).
Cell and nucleus deformation in compressed chondrocyte-alginate constructs: Temporal changes and calculation of cell modulus. Biochimica et Biophysica Acta - General Subjects
vol. 1570,
(1)
1-8.
Holloway I, Knight MM, LEE DA, Bader DL, Bentley G (2002).
Characterisation of cell morphology, cytoskeletal organization and apoptosis in human osteoarthritic cartilage. Trans. Orthop. Res. Soc.
Conference: 48th Annual Meeting of the Orthopaedic Research Society
vol. 27,
Knight MM, Roberts SR, LEE DA, Bader DL (2002).
Light-induced calcium signalling in chondrocytes. Eur. Cells Materials.
Conference: TCES 2002 Annual meeting of the UK Tissue and Cell Engineering Society
(University of Glasgow, Scotland)
from: 19/09/2002
to: 20/09/2002,
vol. 4,
7-8.
Knight MM, Toyoda T, LEE DA, Bader DL (2002).
Mechanical strain and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose. Trans. Orthop. Res. Soc..
Conference: 48th Annual Meeting of the Orthopaedic Research Society
vol. 27,
35-35.
Knight MM, Ross JM, Sherwin AF, Lee DA, Bader DL, Poole CA(2001).
Chondrocyte deformation within mechanically and enzymatically extracted chondrons compressed in agarose. Biochim Biophys Acta
vol. 1526,
(2)
141-146.
Knight MM, Idowu BD, Lee DA, Bader DL(2001).
Temporal changes in cytoskeletal organisation within isolated chondrocytes quantified using a novel image analysis technique. Med Biol Eng Comput
vol. 39,
(3)
397-404.
Bouten CVC, Knight MM, Lee DA, Bader DL(2001).
Compressive deformation and damage of muscle cell subpopulations in a model system. ANN BIOMED ENG
vol. 29,
(2)
153-163.
LEE DA, Idowu BD, Knight MM, Bader DL (2001).
Mechanical compression influences cytoskeletal oragnisation within chondrocytes seeded in agarose constructs. Trans. Orthop. Res. Soc..
Conference: 47th Annual Meeting, Orthopaedic Research Society
(San Francisco, California)
from: 25/02/2001
to: 28/02/2001,
vol. 26,
263-263.
Roberts SR, Knight MM, Lee DA, Bader DL(2001).
Mechanical compression influences intracellular Ca<sup>2+</sup> signaling in chondrocytes seeded in agarose constructs. Journal of Applied Physiology
vol. 90,
(4)
1385-1391.
Knight MM, van de Breevaart Brevenboer J, van Osch G, Weinans H, LEE DA, Bader DL (2001).
Temporal changes in cell and nucleus deformation in isolated chondrocytes compressed in alginate scaffolds. Trans. Orthop. Res. Soc..
Conference: 47th Annual Meeting, Orthopaedic Research Society
(San Francisco, California)
from: 25/02/2001
to: 28/02/2001,
vol. 26,
611-611.
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