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Publications:  Miss Karen Hunt

McGregor TL, Hunt KA, Yee E, Mason D, Nioi P, Ticau S, Pelosi M, Loken PR et al.(2020). Characterising a healthy adult with a rare HAO1 knockout to support a therapeutic strategy for primary hyperoxaluria. eLife vol. 9,
10.7554/eLife.54363
https://qmro.qmul.ac.uk/xmlui/handle/123456789/63498
Finer S, Martin HC, Khan A, Hunt KA, Maclaughlin B, Ahmed Z, Ashcroft R, Durham C et al.(2020). Cohort Profile: East London Genes & Health (ELGH), a community-based population genomics and health study in British Bangladeshi and British Pakistani people. International Journal of Epidemiology vol. 49, (1) 20-21I.
10.1093/ije/dyz174
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62209
Mcgregor TL, Hunt KA, Nioi P, Wright J, Erbe D, Van Heel D (2019). IDENTIFICATION AND PHENOTYPING OF A HEALTHY HUMAN DEFICIENT IN HAO1 SUPPORTS GLYCOLATE OXIDASE KNOCKDOWN AS A POTENTIAL APPROACH TO THERAPY FOR PRIMARY HYPEROXALURIA TYPE 1. NEPHROLOGY DIALYSIS TRANSPLANTATION. vol. 34,
Telomeres Mendelian Randomization Collaboration, Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH et al.(2017). Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study. JAMA Oncol vol. 3, (5) 636-651.
10.1001/jamaoncol.2016.5945
https://qmro.qmul.ac.uk/xmlui/handle/123456789/28275
Narasimhan VM, Hunt KA, Mason D, Baker CL, Karczewski KJ, Barnes MR, Barnett AH, Bates C et al.(2016). Health and population effects of rare gene knockouts in adult humans with related parents. Science vol. 352, (6284) 474-477.
10.1126/science.aac8624
https://qmro.qmul.ac.uk/xmlui/handle/123456789/11646
Gutierrez-Achury J, Zhernakova A, Pulit SL, Trynka G, Hunt KA, Romanos J, Raychaudhuri S, Van Heel DA et al.(2015). Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease. Nature Genetics vol. 47, (6) 577-578.
10.1038/ng.3268
https://qmro.qmul.ac.uk/xmlui/handle/123456789/8667
Mistry V, Bockett NA, Levine AP, Mirza MM, Hunt KA, Ciclitira PJ, Hummerich H, Neuhausen SL et al.(2015). Exome sequencing of 75 individuals from multiply affected coeliac families and large scale resequencing follow up. PLoS ONE vol. 10, (1)
10.1371/journal.pone.0116845
Hunt KA, Mistry V, Bockett NA, Ahmad T, Ban M, Barker JN, Barrett JC, Blackburn H et al.(2013). Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature vol. 498, (7453) 232-235.
10.1038/nature12170
Hunt KA, Smyth DJ, Balschun T, Ban M, Mistry V, Ahmad T, Anand V, Barrett JC et al.(2011). Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nat Genet vol. 44, (1) 3-5.
10.1038/ng.1037
Trynka G, Hunt KA, Bockett NA, Romanos J, Mistry V, Szperl A, Bakker SF, Bardella MT et al.(2011). Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease. Nat Genet vol. 43, (12) 1193-1201.
10.1038/ng.998
Dubois PCA, Trynka G, Franke L, Hunt KA, Romanos J, Curtotti A, Zhernakova A, Heap GAR et al.(2010). Erratum: Multiple common variants for celiac disease influencing immune gene expression (Nature Genetics DOI: 10.1038/ng.543). Nature Genetics vol. 42, (5)
10.1038/ng0510-465
Dubois PCA, Trynka G, Franke L, Hunt KA, Romanos J, Curtotti A, Zhernakova A, Heap GAR et al.(2010). Multiple common variants for celiac disease influencing immune gene expression (vol 42, pg 295, 2010). NATURE GENETICS vol. 42, (5) 465-465.
10.1038/ng0510-465
Dubois PCA, Trynka G, Franke L, Hunt KA, Romanos J, Curtotti A, Zhernakova A, Heap GAR et al.(2010). Multiple common variants for celiac disease influencing immune gene expression. Nat Genet vol. 42, (4) 295-302.
10.1038/ng.543
Heap GA, Yang JHM, Downes K, Healy BC, Hunt KA, Bockett N, Franke L, Dubois PC et al.(2010). Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing. Hum Mol Genet vol. 19, (1) 122-134.
10.1093/hmg/ddp473
Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA et al.(2009). Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappa B signalling. GUT vol. 58, (8) 1078-1083.
10.1136/gut.2008.169052
Dubois PC, Trynka G, Heap GA, Hunt KA, Franke L, van Heel D, Gwilliam R, Deloukas P et al. (2009). Copy Number Variant and Extended SNP Genome Wide Association Study in Celiac Disease. GASTROENTEROLOGY. vol. 136, A263-A263.
Hunt KA, van Heel DA(2009). Recent advances in coeliac disease genetics. Gut vol. 58, (4) 473-476.
10.1136/gut.2008.155879
Zhernakova A, Hunt KA, Franke L, Trynka G, Heap G, Romanos J, Turner G, McGinnis F et al.(2009). Genome-wide association study In coeliac disease: identification of novel genetic risk loci. EUR J GASTROEN HEPAT vol. 21, (3) A45-A45.
Dubois P, Hunt K, van Heel D(2009). Sex differences in HLA DQ in celiac disease. Am J Gastroenterol vol. 104, (3)
10.1038/ajg.2009.16
Heap GA, Trynka G, Jansen RC, Bruinenberg M, Swertz MA, Dinesen LC, Hunt KA, Wijmenga C et al.(2009). Complex nature of SNP genotype effects on gene expression in primary human leucocytes. BMC Med Genomics vol. 2,
10.1186/1755-8794-2-1
Smyth DJ, Plagnol V, Walker NM, Cooper JD, Downes K, Yang JHM, Howson JMM, Stevens H et al.(2008). Shared and Distinct Genetic Variants in Type 1 Diabetes and Celiac Disease. NEW ENGL J MED vol. 359, (26) 2767-2777.
10.1056/NEJMoa0807917
Franke L, de Kovel CGE, Aulchenko YS, Trynka G, Zhernakova A, Hunt KA, Blauw HM, van den Berg LH et al.(2008). Detection, imputation, and association analysis of small deletions and null alleles on oligonucleotide arrays. AM J HUM GENET vol. 82, (6) 1316-1333.
10.1016/j.ajhg.2008.05.008
Hunt KA, Franke L, Deloukas P, Wjmenga C, Van Heel DA(2008). No evidence in a large UK collection for celiac disease risk variants reported by a Spanish study. GASTROENTEROLOGY vol. 134, (5) 1629-1630.
10.1053/j.gastro.2008.03.068
Hunt KA, Zhernakova A, Turner G, Heap GAR, Franke L, Bruinenberg M, Romanos J, Dinesen LC et al.(2008). Newly identified genetic risk variants for celiac disease related to the immune response. Nat Genet vol. 40, (4) 395-402.
10.1038/ng.102
https://qmro.qmul.ac.uk/xmlui/handle/123456789/3282
van Heel DA, Franke L, Hunt KA, Gwilliam R, Zhernakova A, Inouye M, Wapenaar MC, Barnardo MCNM et al.(2007). A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. Nat Genet vol. 39, (7) 827-829.
10.1038/ng2058
Van Bodegraven AA, Curley CR, Hunt KA, Monsuur AJ, Linskens RK, Onnie CM, Crusius JBA, Annese V et al.(2006). Genetic variation in myosin IXB is associated with ulcerative colitis. GASTROENTEROLOGY vol. 131, (6) 1768-1774.
10.1053/j.gastro.2006.09.011
van Heel DA, Hunt KA, King K, Ghosh S, Gabe SM, Mathew CG, Forbes A, Playford RJ(2006). Detection of muramyl dipeptide-sensing pathway defects in patients with Crohn's disease. Inflamm Bowel Dis vol. 12, (7) 598-605.
10.1097/01.ibd.0000225344.21979.89
Hunt KA, Monsuur AJ, McArdle WL, Kumar PJ, Travis SPL, Walters JRF, Jewell DP, Strachan DP et al.(2006). Lack of association of MYO9B genetic variants with coeliac disease in a British cohort. Gut vol. 55, (7) 969-972.
10.1136/gut.2005.086769
https://qmro.qmul.ac.uk/xmlui/handle/123456789/173
van Heel DA, Hunt KA, Ghosh S, King K, Gabe S, Mathew CG, Forbes A, Playford RJ (2006). Detection of muramyl dipeptide sensing pathway defects in patients with Crohn's disease. GUT. vol. 55, A17-A17.
van Heel DA, Hunt KA, Ghosh S, Herve M, Playford RJ (2006). Normal responses to specific NOD1 activating peptidoglycan agonists in the presence of the NOD2 frameshift and other mutations in Crohn's disease. GUT. vol. 55, A76-A76.
PLAYFORD RJ, VAN HEEL DA, HERVE M, HUNT KA, GHOSH S(2006). Normal responses to specific NOD1-activating peptidoglycan agonists in the presence of the NOD2 frameshift and other mutations in Crohn's disease. EUR J IMMUNOL vol. 36, 1629-1635.
10.1002/eji.200535636
VAN HEEL DA, WIJMENGA C, GRECO L, HUNT KA(2005). Genetics in coeliac disease. Best Pract Res Clin Gastroenterol vol. 19, (3) 323-329.
10.1016/j.bpg.2005.01.001
PLAYFORD RJ, VAN HEEL DA, BUTLER M, GHOSH S, FORBES A, JEWELL DP, MATTHEW CG, GOLDTHORPE S et al.(2005). Muramyl dipeptide and Toll-like receptor sensitivity in NOD2 associated Crohn's disease. LANCET vol. 365, 1794-1796.
10.1016/S0140-6736(05)66582-8
PLAYFORD RJ, VAN HEEL DA, FORBES A, MATHEW CG, JEWELL DP, BUTLER M, GHOSH S, FOXWELL BM et al.(2005). Muramyl dipeptide and Toll-like receptor sensitivity in NOD2 associated Crohn’s disease. Lancet vol. 365, 1794-1796.
10.1016/S0140-6796(05)66582-8
Hunt KA, McGovern DPB, Kumar PJ, Ghosh S, Travis SPL, Walters JRF, Jewell DP, Playford RJ et al. (2005). A common CTLA4 haplotype associated with coeliac disease. GUT. vol. 54, A37-A37.
10.1038/sj.ejhg.5201357
van Heel DA, Ghosh S, Butler M, Hunt KA, Lundberg A, Ahmad T, McGovern DPB, Onnie C et al. (2005). Amplification of Toll-like receptor sensitivity by muramyl dipeptide is impaired in Crohn's disease associated NOD2 mutations. GUT. vol. 54, A1-A1.
Cummings JRF, Hunt KA, Playford R, Kumar P, Jewell DP, van Heel D (2005). Investigation of the Dlg5 gene in coeliac disease. GASTROENTEROLOGY. vol. 128, A254-A254.
HUNT K, BUTLER M, GHOSH S, PLAYFORD RJ, VAN HEEL DA, MENGIN-LECREULX D, FOXWELL BMJ(2005). Synergistic enhancement of Toll-like receptor responses by NOD1 activation. Eur J Immunol. vol. 35, 2471-2476.
10.1002/eji.200526296
PLAYFORD R, VAN HEEL D, JEWELL R, MATHEW C, FORBES A, HUNT K, GHOSH S(2005). Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn’s disease. Gut vol. 54, (11) 1553-1557.
10.1136/gut.2005.065888
https://qmro.qmul.ac.uk/xmlui/handle/123456789/1022
Hunt KA, McGovern DPB, Kumar PJ, Ghosh S, Travis SPL, Walters JRF, Jewell DP, Playford RJ et al. (2004). Genetic variation in the T cell regulatory gene CTLa4 is associated with early onset celiac disease. GASTROENTEROLOGY. vol. 126, A253-A253.
Hunt KA, Hernandez-Fuentes M, Butler M, Travis SPL, Ghosh S, Jewell DP, Walters JRF, Playford RJ et al. (2004). Quantitative and functional defect of peripheral blood NKT cells in Celiac disease. GASTROENTEROLOGY. vol. 126, A12-A12.
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