Publications: Dr Robert Janes
Wallace BA, Janes RW
(
2023
)
.
The PCDDB project: Tools and resources for CD analyses, archiving, display, and sharing
.
Biophysical journal
vol.
122
,
(
3S1
)
Ramalli SG, Miles AJ, Janes RW, Wallace BA
(
2022
)
.
The PCDDB (Protein Circular Dichroism Data Bank): A Bioinformatics Resource for Protein Characterisations and Methods Development
.
Journal of Molecular Biology
vol.
434
,
(
11
)
Miles AJ, Janes RW, Wallace BA
(
2021
)
.
Tools and methods for circular dichroism spectroscopy of proteins: A tutorial review
.
Chemical Society Reviews
vol.
50
,
(
15
)
8400
-
8413
.
Drew ED, Janes RW
(
2020
)
.
Identification of a druggable binding pocket in the spike protein reveals a key site for existing drugs potentially capable of combating Covid-19 infectivity
.
BMC Molecular Biology
vol.
21
,
(
1
)
49
-
49
.
Janes R, Drew E
(
2020
)
.
PDBMD2CD: Providing Predicted Protein Circular Dichroism Spectra from Multiple Molecular Dynamics-Generated Protein Structures
.
Nucleic Acids Research
Wallace BA, Janes RW, Miles A, Drew ED, Whitmore L, Ramalli SG
(
2020
)
.
Tools and Resources for Circular Dichroism Spectroscopy
.
Biophysical Journal
.
vol.
118
,
Janes RW, Drew ED
(
2019
)
.
2StrucCompare: A webserver for visualizing small but noteworthy differences between protein tertiary structures through interrogation of the secondary structure content
.
Nucleic Acids Research
Drew ED, Mavridis L, Janes RW
(
2018
)
.
PDB2CD: A Web-Based Application for the Generation of Circular Dichroism Spectra from Protein Atomic Coordinates
.
Biophysical Journal
.
vol.
114
,
Whitmore L, Mavridis L, Wallace BA, Janes RW
(
2017
)
.
DichroMatch at the protein circular dichroism data bank (DM@PCDDB): A web-based tool for identifying protein nearest neighbors using circular dichroism spectroscopy
.
Protein Science
vol.
27
,
(
1
)
10
-
13
.
Janes RW
(
2017
)
.
PDB2CD visualises dynamics within protein structures
.
European Biophysics Journal
vol.
46
,
(
7
)
607
-
616
.
Janes R
(
2017
)
.
Shining light on membrane proteins
.
Eur Biophys J
vol.
46
,
(
7
)
597
-
597
.
Janes RW
(
2017
)
.
PDB2CD: A novel tool for protein structure/function analysis
.
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
.
vol.
46
,
S163
-
S163
.
Mavridis L, Janes RW
(
2016
)
.
PDB2CD: A web-based application for the generation of circular dichroism spectra from protein atomic coordinates
.
Bioinformatics
Whitmore L, Miles AJ, Mavridis L, Janes RW, Wallace BA
(
2016
)
.
PCDDB: new developments at the Protein Circular Dichroism Data Bank
.
Nucleic Acids Research
Woollett B, Whitmore L, Janes RW, Wallace BA
(
2013
)
.
ValiDichro: a website for validating and quality control of protein circular dichroism spectra
.
Nucleic Acids Res
vol.
41
,
(
Web Server issue
)
W417
-
W421
.
Whitmore L, Woollett B, Janes RW, Wallace BA
(
2013
)
.
The Protein Circular Dichroism Data Bank: A Resource for Data Sharing
.
BIOPHYSICAL JOURNAL
.
vol.
104
,
567A
-
567A
.
Janes RW
(
2013
)
.
Protein Circular Dichroism Data Bank
.
Encyclopedia of Biophysics
,
Janes RW, Miles AJ, Woollett B, Whitmore L, Klose D, Wallace BA
(
2012
)
.
Circular dichroism spectral data and metadata in the Protein Circular Dichroism Data Bank (PCDDB): a tutorial guide to accession and deposition
.
Chirality
vol.
24
,
(
9
)
751
-
763
.
Klose DP, Wallace BA, Janes RW
(
2012
)
.
DichroMatch: a website for similarity searching of circular dichroism spectra
.
Nucleic Acids Res
vol.
40
,
(
Web Server issue
)
W547
-
W552
.
Woollett B, Klose D, Cammack R, Janes RW, Wallace BA
(
2012
)
.
JCAMP-DX for circular dichroism spectra and metadata (IUPAC Recommendations 2012)
.
PURE AND APPLIED CHEMISTRY
vol.
84
,
(
10
)
2171
-
2182
.
Wallace BA, Gekko K, Vronning Hoffmann S, Lin YH, Sutherland JC, Tao Y, Wien F, Janes RW
(
2011
)
.
Synchrotron radiation circular dichroism (SRCD) spectroscopy: An emerging method in structural biology for examining protein conformations and protein interactions
.
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
.
vol.
649
,
177
-
178
.
Woollett B, Whitmore L, Miles AJ, Janes RW, Wallace BA
(
2011
)
.
Validichro, a Software Tool for Validation of Circular Dichroism (CD) Spectroscopic Data
.
Biophysical Journal
.
vol.
100
,
Whitmore L, Woollett B, Miles AJ, Klose DP, Janes RW, Wallace BA
(
2011
)
.
PCDDB: the Protein Circular Dichroism Data Bank, a repository for circular dichroism spectral and metadata
.
Nucleic Acids Res
vol.
39
,
(
Database issue
)
D480
-
D486
.
Klose DP, Wallace BA, Janes RW
(
2010
)
.
2Struc: the secondary structure server
.
Bioinformatics
vol.
26
,
(
20
)
2624
-
2625
.
Whitmore L, Woollett B, Miles AJ, Janes RW, Wallace BA
(
2010
)
.
The protein circular dichroism data bank, a Web-based site for access to circular dichroism spectroscopic data
.
Structure
vol.
18
,
(
10
)
1267
-
1269
.
Wallace BA, Janes RW
(
2010
)
.
Synchrotron radiation circular dichroism (SRCD) spectroscopy: an enhanced method for examining protein conformations and protein interactions
.
Biochem Soc Trans
vol.
38
,
(
4
)
861
-
873
.
Klose DP, Janes RW
(
2010
)
.
2°Struc - the Protein Secondary Structure Analysis Server
.
Biophysical Journal
.
vol.
98
,
454a
-
455a
.
Whitmore L, Woollett B, Miles AJ, Janes RW, Wallace BA
(
2010
)
.
The Protein Circular Dichroism Data Bank (PCDDB) - First Release of a New Resource for Spectroscopic Data Sharing
.
Biophysical Journal
.
vol.
98
,
196a
-
197a
.
Janes RW, Wallace BA
(
2009
)
.
An introduction to circular dichroism and synchrotron radiation circular dichroism spectroscopy
.
Janes RW
(
2009
)
.
Reference datasets for protein circular dichroism and synchrotron radiation circular dichroism spectroscopic analyses
.
Advances in Biomedical Spectroscopy
vol.
1
,
183
-
201
.
Wallace BA, Whitmore L, Janes RW
(
2009
)
.
The protein circular dichroism data bank (PCDDB): A resource for data archiving, sharing, validation and analysis
.
Advances in Biomedical Spectroscopy
vol.
1
,
216
-
227
.
Janes RW
(
2009
)
.
The pet
.
NATURE
vol.
461
,
(
7261
)
304
-
304
.
Miles AJ, Janes RW, Brown A, Clarke DT, Sutherland JC, Tao Y, Wallace BA, Hoffmann SV
(
2008
)
.
Light flux density threshold at which protein denaturation is induced by synchrotron radiation circular dichroism beamlines
.
J Synchrotron Radiat
vol.
15
,
(
Pt 4
)
420
-
422
.
Lees JG, Janes RW
(
2008
)
.
Combining sequence-based prediction methods and circular dichroism and infrared spectroscopic data to improve protein secondary structure determinations
.
BMC BIOINFORMATICS
vol.
9
,
Article
24
,
Maytum R, Janes RW
(
2007
)
.
Synchrotron Radiation Circular Dichroism spectroscopy reveals a new structural transition in tropomyosin
.
BIOPHYSICAL JOURNAL
.
362A
-
362A
.
Miles AJ, Hoffmann SV, Tao Y, Janes RW, Wallace BA
(
2007
)
.
Synchrotron radiation circular dichroism (SRCD) spectroscopy: New beamlines and new applications in biology
.
SPECTROSC-INT J
vol.
21
,
(
5-6
)
245
-
255
.
Lees JG, Miles AJ, Janes RW, Wallace BA
(
2006
)
.
Novel methods for secondary structure determination using low wavelength (VUV) circular dichroism spectroscopic data
.
BMC Bioinformatics
vol.
7
,
Cuff AL, Janes RW, Martin ACR
(
2006
)
.
Analysing the ability to retain sidechain hydrogen-bonds in mutant proteins
.
Bioinformatics
vol.
22
,
(
12
)
1464
-
1470
.
Whitmore L, Janes RW, Wallace BA
(
2006
)
.
Protein Circular Dichroism Data Bank (PCDDB): data bank and website design
.
Chirality
vol.
18
,
(
6
)
426
-
429
.
JANES RW, Lees JG, Miles AJ, Stone TC, Wallace BA, Wien F
(
2006
)
.
A Circular Dichroism Reference Database for Membrane Proteins
.
Biophysical Journal
vol.
90
,
Wallace BA, Whitmore L, Janes RW
(
2006
)
.
The Protein Circular Dichroism Data Bank (PCDDB): A bioinformatics and spectroscopic resource
.
PROTEINS
vol.
62
,
(
1
)
1
-
3
.
Janes RW
(
2005
)
.
Bioinformatics analyses of circular dichroism protein reference databases
.
Bioinformatics
vol.
21
,
(
23
)
4230
-
4238
.
Janes RW, Cuff AL
(
2005
)
.
Overcoming protein denaturation caused by irradiation in a high-flux synchrotron radiation circular dichroism beamline
.
J Synchrotron Radiat
vol.
12
,
(
Pt 4
)
524
-
529
.
Janes RW, O'Boyle F, Mezo G, Hudecz F
(
2005
)
.
Structural investigations of alpha-Conotoxin SI chimeras containing epitopes from Herpes Simplex Virus and cancer-related Mucin proteins reveal notable conformational differences
.
FEBS JOURNAL
.
vol.
272
,
526
-
526
.
Janes RW
(
2005
)
.
alpha-Conotoxins as selective probes for nicotinic acetylcholine receptor subclasses
.
Curr Opin Pharmacol
vol.
5
,
(
3
)
280
-
292
.
Hawkes NJ, Janes RW, Hemingway J, Vontas J
(
2005
)
.
Detection of resistance-associated point mutations of organophosphate-insensitive acetylcholinesterase in the olive fruit fly, Bactrocera oleae (Gmelin)
.
PESTIC BIOCHEM PHYS
vol.
81
,
(
3
)
154
-
163
.
Wien F, Miles AJ, Lees JG, Cuff AL, Janes RW, Wallace BA
(
2005
)
.
A new circular dichroism spectroscopy reference dataset covering fold space
.
BIOPHYSICAL JOURNAL
.
vol.
88
,
554A
-
554A
.
JANES RW, Wallace BA
(
2005
)
.
Meeting Reports: International Workshop on the Protein Circular Dichroism Data Bank
.
Synchrotron Radiation News
vol.
18
,
(
4
)
20
-
21
.
Miles AJ, Wien F, Lees JG, Rodger A, Janes RW, Wallace BA
(
2004
)
.
A method for calibration and standardisation of synchrotron radiation circular dichroism (SRCD) and conventional circular dichroism spectrophotometers and its applications to protein secondary structure analyses
.
BIOPHYSICAL JOURNAL
.
vol.
86
,
358A
-
358A
.
Wallace BA, Janes RW
(
2003
)
.
Circular dichroism and synchrotron radiation circular dichroism spectroscopy: tools for drug discovery (vol 31, pg 631, 2003)
.
BIOCHEM SOC T
vol.
31
,
1531
-
1531
.
Vontas JG, Hejazi MJ, Hawkes NJ, Cosmidis N, Loukas M, Janes RW, Hemingway J
(
2003
)
.
Erratum: Resistance-associated point mutations of organophosphate insensitive acetylcholinesterase, in the olive fruit fly Bactrocera oleae (Insect Molecular Biology (2002) 11 (329-336))
.
Insect Molecular Biology
vol.
12
,
(
4
)
Vontas JG, Hejazi MJ, Hawkes NJ, Cosmidis N, Loukas M, Janes RW, Hemingway J
(
2003
)
.
Resistance-associated point mutations of organophosphate insensitive acetylcholinesterase, in the olive fruit fly Bactrocera oleae (vol 11, pg 329, 2002)
.
INSECT MOL BIOL
vol.
12
,
(
4
)
413
-
413
.
Wallace BA, Janes RW
(
2003
)
.
Circular dichroism and synchrotron radiation circular dichroism spectroscopy: tools for drug discovery
.
BIOCHEM SOC T
vol.
31
,
631
-
633
.
Janes RW
(
2003
)
.
Nicotinic acetylcholine receptors: alpha-conotoxins as templates for rational drug design
.
BIOCHEM SOC T
vol.
31
,
634
-
636
.
Wallace BA, Lees JG, Orry AJW, Lobley A, Janes RW
(
2003
)
.
Analyses of circular dichroism spectra of membrane proteins
.
Protein Sci
vol.
12
,
(
4
)
875
-
884
.
Wallace BA, Lees JG, Orry A, Wien F, Whitmore L, Lobley A, Janes RW
(
2003
)
.
Circular dichroism analyses of membrane proteins
.
BIOPHYSICAL JOURNAL
.
vol.
84
,
136A
-
136A
.
Miles AJ, Wien F, Lees JG, Rodger A, Janes RW, Wallace BA
(
2003
)
.
Calibration and standardisation of synchrotron radiation circular dichroism and conventional circular dichroism spectrophotometers
.
SPECTROSC-INT J
vol.
17
,
(
4
)
653
-
661
.
Wallace BA, Janes RW
(
2003
)
.
Erratum: Circular dichroism and synchrotron radiation circular dichroism spectroscopy - Tools for drug discovery (Biochemical Society Transactions (2003) 31:3 (631-633))
.
Biochemical Society Transactions
vol.
31
,
(
6
)
Vontas JG, Hejazi MJ, Hawkes NJ, Cosmidis N, Loukas M, Janes RW, Hemingway J
(
2002
)
.
Resistance-associated point mutations of organophosphate insensitive acetylcholinesterase, in the olive fruit fly Bactrocera oleae
.
Insect Mol Biol
vol.
11
,
(
4
)
329
-
336
.
Wallace BA, Lees J, Janes RW
(
2002
)
.
Fold recognition by Synchrotron Radiation Circular Dichroism (SRCD) spectroscopy: A new tool for structural genomics
.
BIOPHYS J
vol.
82
,
(
1
)
360A
-
360A
.
Janes RW, Whitford D, Benie AJ, Hargittai B, Barany G
(
2002
)
.
Structural studies on α-conotoxin SI
.
vol.
6
,
730
-
732
.
Wallace BA, Janes RW
(
2001
)
.
Synchrotron radiation circular dichroism spectroscopy of proteins: secondary structure, fold recognition and structural genomics
.
CURR OPIN CHEM BIOL
vol.
5
,
(
5
)
567
-
571
.
Orry AJW, Janes RW, Sarra R, Hanlon MR, Wallace BA
(
2001
)
.
Synchrotron radiation circular dichroism spectroscopy: vacuum ultraviolet irradiation does not damage protein integrity
.
J SYNCHROTRON RADIAT
vol.
8
,
1027
-
1029
.
Janes RW, Potter BS, Naylor MA, Ferguson AC, Patel KB, Stratford MRL, Wardman P, Everett SA
(
2001
)
.
1-Methylindole-3-carboxaldehyde oxime derivatives
.
ACTA CRYSTALLOGR C
vol.
57
,
58
-
61
.
Wallace BA, Janes RW, Orry A
(
2001
)
.
Secondary structure information content on the VUV region of synchrotron radiation circular dichroism (SRCD) spectra
.
BIOPHYS J
vol.
80
,
(
1
)
28A
-
28A
.
Wallace BA, Janes RW
(
2000
)
.
Tryptophans in membrane proteins: X-ray crystallographic analyses
.
Advances in Experimental Medicine and Biology
.
vol.
467
,
789
-
799
.
Benie AJ, Whitford D, Hargittai B, Barany G, Janes RW
(
2000
)
.
Solution structure of α-conotoxin SI
.
FEBS Letters
vol.
476
,
(
3
)
287
-
295
.
Janes RW
(
2000
)
.
1-[5-[2-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl]guanidinium chloride
.
Acta Crystallographica, Section C: Crystal Structure Communications
vol.
56
,
Janes RW
(
2000
)
.
3,5-diamino-6-(2-fluorophenyl)-1,2,4-triazine-dimethylformamide (1/1)
.
Acta Crystallographica, Section C: Crystal Structure Communications
vol.
56
,
Janes RW
(
2000
)
.
1-{5-[2-(Trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl}guanidinium chloride
.
Acta Crystallographica Section C: Crystal Structure Communications
vol.
56
,
(
4
)
508
-
509
.
Janes RW
(
2000
)
.
3,5-Diamino-6-(2-fluorophenyl)-1,2,4-triazine-dimethylformamide (1/1)
.
Acta Crystallographica Section C: Crystal Structure Communications
vol.
56
,
(
3
)
362
-
364
.
Rodi DJ, Janes RW, Sanganee HJ, Holton RA, Wallace BA, Makowski L
(
1999
)
.
Screening of a library of phage-displayed peptides identifies human Bcl-2 as a Taxol-binding protein
.
Journal of Molecular Biology
vol.
285
,
(
1
)
197
-
203
.
Janes RW
(
1999
)
.
Crystal structure of an analog of the anticonvulsant lamotrigine, 3,5-diamino-6-(2,3,5-trichlorophenyl)-1,2,4-triazine · dimethanolate, and structure comparisons with related analogs
.
Journal of Chemical Crystallography
vol.
29
,
(
2
)
163
-
167
.
Mitchison HM, Taschner PEM, Kremmidiotis C, Callen DF, Doggett NA, Lerner TJ, Janes RB, Wallace BA et al.
(
1997
)
.
Structure of the CLN3 gene and predicted structure, location and function of CLN3 protein
.
Neuropediatrics
vol.
28
,
(
1
)
12
-
14
.
Janes RW, Munroe PB, Mitchison HM, Gardiner RM, Mole SE, Wallace BA
(
1996
)
.
A model for Batten disease protein CLN3: Functional implications from homology and mutations
.
FEBS Letters
vol.
399
,
(
1-2
)
75
-
77
.
Janes RW, Palmer RA
(
1996
)
.
3,5-Diamino-6-(2-bromophenyl)-1,2,4-triazine dimethanol solvate: An analogue of lamotrigine
.
Acta Crystallographica Section C: Crystal Structure Communications
vol.
52
,
(
10
)
2627
-
2629
.
Peto H, Corder R, Janes RW, Wallace BA
(
1996
)
.
A molecular model for human Big-Endothelin-1 (Big ET-1)
.
FEBS Letters
vol.
394
,
(
2
)
191
-
195
.
Peishoff CE, Janes RW, Wallace BA
(
1995
)
.
Comparison of the structures of the endothelin A receptor antagonists BQ123 and N-methyl leucine BQ123 with the crystal structure of the C-terminal tail of endothelin-1
.
FEBS Letters
vol.
374
,
(
3
)
379
-
383
.
Janes RW, Palmer RA
(
1995
)
.
Practical limitations observed using the AM1, MNDO and MINDO/3 semi-empirical methods for charge calculation and structure optimization in 1,2,4-triazine ring-containing compounds
.
Journal of Molecular Structure: THEOCHEM
vol.
339
,
(
1-3
)
95
-
101
.
Wallace BA, Janes RW, Bassolino DA, Krystek SR
(
1995
)
.
A comparison of X‐ray and NMR structures for human endothelin‐1
.
Protein Science
vol.
4
,
(
1
)
75
-
83
.
Lapthorn AJ, Janes RW, Isaacs NW, Wallace BA
(
1995
)
.
Cystine nooses and protein specificity
.
Nature Structural Biology
vol.
2
,
(
4
)
266
-
268
.
Wallace BA, Janes RW
(
1995
)
.
The crystal structure of human endothelin-1 and how it relates to receptor binding
.
Journal of Cardiovascular Pharmacology
vol.
26
,
S250
-
S253
.
Janes RW, Wallace BA
(
1994
)
.
Modelling the structures of the isoforms of human endothelins based on the crystal structure of human endothelin-1
.
Biochemical Society Transactions
.
vol.
22
,
1037
-
1043
.
Janes RW, Peapus DH, Wallace BA
(
1994
)
.
The crystal structure of human endothelin
.
Nature Structural Biology
vol.
1
,
(
5
)
311
-
319
.
Peapus DH, Janes RW, Wallace BA
(
1993
)
.
Preliminary crystallization and X-ray analysis of orthorhombic human endothelin
.
Journal of Molecular Biology
vol.
234
,
(
4
)
1250
-
1252
.
Wood SP, Janes RW, Sweeney E, Palmer RA
(
1992
)
.
Crystallization of bovine pancreatic polypeptide in the presence of crystalline diglycidyl ether of bisphenol A (Araldite): epitaxy or covalent nucleation?
.
Journal of Crystal Growth
vol.
122
,
(
1-4
)
204
-
207
.
Wallace BA, Janes RW
(
1991
)
.
Co-crystals of gramicidin A and phospholipid. A system for studying the structure of a transmembrane channel
.
Journal of Molecular Biology
vol.
217
,
(
4
)
625
-
627
.