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Publications:  Dr Li Jia

Smith LD, Minton AR, Blunt MD, Karydis LI, Dutton DA, Rogers-Broadway K-R, Dobson R, Liu R et al.(2019). BCR signaling contributes to autophagy regulation in chronic lymphocytic leukemia. Leukemia
10.1038/s41375-019-0557-y
Wang HQ, Jia L, Li YT, Farren T, Agrawal SG, Liu FT(2019). Increased autocrine interleukin-6 production is significantly associated with worse clinical outcome in patients with chronic lymphocytic leukemia. Journal of Cellular Physiology vol. 234, (8) 13994-14006.
10.1002/jcp.28086
https://qmro.qmul.ac.uk/xmlui/handle/123456789/55138
Zhang T, Guan X-W, Gribben JG, Liu F-T, Jia L(2019). Blockade of HMGB1 signaling pathway by ethyl pyruvate inhibits tumor growth in diffuse large B-cell lymphoma. Cell Death Dis vol. 10, (5)
10.1038/s41419-019-1563-8
Wang PG, Li YT, Pan Y, Gao ZZ, Guan XW, Jia L, Liu FT(2019). Lower expression of Bax predicts poor clinical outcome in patients with glioma after curative resection and radiotherapy/chemotherapy. Journal of Neuro-Oncology vol. 141, (1) 71-81.
10.1007/s11060-018-03031-9
Zhao T, Ren H, Jia L, Chen J, Xin W, Yan F, Li J, Wang X et al.(2019). Correction: Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma (Oncotarget (2015) 6 (2250–2262) DOI: 10.18632/oncotarget.2948). Oncotarget vol. 10, (53) 5569-5570.
10.18632/oncotarget.27205
Wang X, Dong J, Jia L, Zhao T, Lang M, Li Z, Lan C, Li X et al.(2017). HIF-2-dependent expression of stem cell factor promotes metastasis in hepatocellular carcinoma. Cancer Letters vol. 393, 113-124.
10.1016/j.canlet.2017.01.032
Liu FT, Jia L, Wang P, Farren T, Li H, Hao X, Agrawal SG(2016). CD126 and targeted therapy with tocilizumab in chronic lymphocytic leukemia. Clinical Cancer Research vol. 22, (10) 2462-2469.
10.1158/1078-0432.CCR-15-1139
Liu F-T, Jia L, Wang P, Wang H, Farren TW, Agrawal SG(2016). STAT3 and NF-κB cooperatively control <i>in vitro</i> spontaneous apoptosis and poor chemo-responsiveness in patients with chronic lymphocytic leukemia. Oncotarget
10.18632/oncotarget.8672
https://qmro.qmul.ac.uk/xmlui/handle/123456789/18352
Wang X, Ren H, Zhao T, Ma W, Dong J, Zhang S, Xin W, Yang S et al.(2016). Single nucleotide polymorphism in the microRNA-199a binding site of HIF1A gene is associated with pancreatic ductal adenocarcinoma risk and worse clinical outcomes. Oncotarget vol. 7, (12) 13717-13729.
10.18632/oncotarget.7263
Norster F, Clear AJ, Matthews J, Hoxha E, Gribben J, Jia L (2015). Overexpression of HMGB1 Receptor RAGE Is Associated with Worse Clinical Outcome in Patients with Chronic Lymphocytic Leukemia. BLOOD. vol. 126,
Wang P, Wang P, Liu B, Zhao J, Pang Q, Agrawal SG, Jia L, Liu FT(2015). Dynamin-related protein Drp1 is required for Bax translocation to mitochondria in response to irradiation-induced apoptosis. Oncotarget vol. 6, (26) 22598-22612.
10.18632/oncotarget.4200
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12775
Zhao T, Ren H, Jia L, Chen J, Xin W, Yan F, Li J, Wang X et al.(2015). Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma. Oncotarget vol. 6, (4) 2250-2262.
10.18632/oncotarget.2948
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6420
Zhao T, Ren H, Wang X, Liu P, Yan F, Jiang W, Li Y, Li J et al.(2015). Rituximab-induced HMGB1 release is associated with inhibition of STAT3 activity in human diffuse large B-cell lymphoma. Oncotarget vol. 6, (29) 27816-27831.
10.18632/oncotarget.4816
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12776
McCarthy A, Clear AJ, Marzec J, Coutinho R, Petty RD, Matthews J, Wilson A, Iqbal S et al. (2014). Overexpression of BCL-2 Does Not Inhibit Autophagy in Human Follicular and Diffuse Large B-Cell Lymphomas. BLOOD. vol. 124,
JIA L(2014). Dysregulation of autophagy in human follicular lymphoma is independent of overexpression of BCL-2. Oncotarget11653-11668.
10.18632/oncotarget.2605
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12767
Wang X, Ren H, Zhao T, Chen J, Sun W, Sun Y, Ma W, Wang J et al.(2014). Stem cell factor is a novel independent prognostic biomarker for hepatocellular carcinoma after curative resection. Carcinogenesis vol. 35, (10) 2283-2290.
10.1093/carcin/bgu162
Jia L, Gribben JG(2014). Dangerous power: Mitochondria in CLL cells. Blood vol. 123, (17) 2596-2597.
10.1182/blood-2014-03-558965
Jia L, Gribben JG(2014). Dangerous power: mitochondria in CLL cells.
Jia L, Clear A, Liu F-T, Matthews J, Uddin N, McCarthy A, Hoxha E, Durance C et al.(2014). Extracellular HMGB1 promotes differentiation of nurse-like cells in chronic lymphocytic leukemia. Blood vol. 123, (11) 1709-1719.
10.1182/blood-2013-10-529610
McCarthy A, Marzec J, Clear A, Petty RD, Coutinho R, Matthews J, Wilson A, Iqbal S et al.(2014). Dysregulation of autophagy in human follicular lymphoma is independent of overexpression of BCL-2. Oncotarget vol. 5, (22) 11653-11668.
10.18632/oncotarget.2605
Jia L, Liu F-T(2013). Why bortezomib cannot go with 'green'?. Cancer Biol Med vol. 10, (4) 206-213.
10.7497/j.issn.2095-3941.2013.04.004
https://qmro.qmul.ac.uk/xmlui/handle/123456789/13710
Miraki-Moud F, Anjos-Afonso F, Hodby KA, Griessinger E, Rosignoli G, Lillington D, Jia L, Davies JK et al.(2013). Acute myeloid leukemia does not deplete normal hematopoietic stem cells but induces cytopenias by impeding their differentiation. Proc Natl Acad Sci U S A vol. 110, (33) 13576-13581.
10.1073/pnas.1301891110
McCarthy A, Yeung V, Gribben JG, Jia L (2012). Inhibition of Autophagy by Chloroquine Sensitises Lymphoma Cells to ABT-737-Induced Apoptosis. BLOOD. vol. 120,
10.1182/blood.V120.21.1625.1625
JIA L, Gopinathan G, Sukumar JT, Gribben JG(2012). Blocking Autophagy Prevents Bortezomib-Induced NF-kappaB Activation by Reducing I-kappaBalpha Degradation in Lymphoma Cells. PLoS One vol. 7, (2) Article e32584,
10.1371/journal.pone.0032584
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12768
Kassam S, Juliger S, Jia L, Joel SP(2012). Methylseleninic acid antagonizes the cytotoxic effect of bortezomib in mantle cell lymphoma cell lines through modulation of Bcl-2 family proteins. Br J Haematol vol. 156, (2) 286-289.
10.1111/j.1365-2141.2011.08861.x
Jia L, Uddin N, Gribben JG (2011). Activation of Mitochondrial STAT3 Increases Mitochondrial Respiration and Inhibits Oxidative Stress in Chronic Lymphocytic Leukemic Cells. BLOOD. vol. 118, 133-133.
Liu F, Jia L, Farren TW, Gribben JG, Agrawal SG (2011). Autocrine IL-6 Production Indicates the Level of Activated STAT3 and NF-Kb of Chronic Lymphocytic Leukemia Cells. BLOOD. vol. 118, 778-778.
Liu FT, Jia L, Farren T, Gribben JG, Agrawal S (2010). Autocrine IL6/STAT3 Signaling Enhances Survival of Chronic Lymphocytic Leukaemia Cells. BLOOD. vol. 116, 1481-1481.
Jia L, Gopinathan G, Sukumar JT, Gribben JG (2010). Potentiation of Bortezomib-Induced Killing of Lymphoma Cells by Inhibition of Autophagy and Prevention of I-kappa B alpha Degradation. BLOOD. vol. 116, 57-57.
Liu F-T, Giustiniani J, Farren T, Jia L, Bensussan A, Gribben JG, Agrawal SG(2010). CD160 signaling mediates PI3K-dependent survival and growth signals in chronic lymphocytic leukemia. Blood vol. 115, (15) 3079-3088.
10.1182/blood-2009-08-239483
https://qmro.qmul.ac.uk/xmlui/handle/123456789/1029
Agrawal SG, Liu FT, Giustiniani J, Jia L, Gribben JG, Bensussan A (2008). Dual Action of CD160 on CLL Cells: Giving Life to Prepare for Death!. BLOOD. vol. 112, 726-726.
Liu F-T, Agrawal SG, Movasaghi Z, Wyatt PB, Rehman IU, Gribben JG, Newland AC, Jia L(2008). Dietary flavonoids inhibit the anticancer effects of the proteasome inhibitor bortezomib. Blood vol. 112, (9) 3835-3846.
10.1182/blood-2008-04-150227
https://qmro.qmul.ac.uk/xmlui/handle/123456789/1075
Yu M, Liu F-T, Newland AC, Jia L(2008). The alpha-5 helix of Bax is sensitive to ubiquitin-dependent degradation. Biochem Biophys Res Commun vol. 371, (1) 10-15.
10.1016/j.bbrc.2008.03.122
Liu F-T, Agrawal SG, Gribben JG, Ye H, Du M-Q, Newland AC, Jia L(2008). Bortezomib blocks Bax degradation in malignant B cells during treatment with TRAIL. Blood vol. 111, (5) 2797-2805.
10.1182/blood-2007-08-110445
https://qmro.qmul.ac.uk/xmlui/handle/123456789/1076
Agrawal SG, Liu F-T, Wiseman C, Shirali S, Liu H, Lillington D, Du M-Q, Syndercombe-Court D et al.(2008). Increased proteasomal degradation of Bax is a common feature of poor prognosis chronic lymphocytic leukemia. Blood vol. 111, (5) 2790-2796.
10.1182/blood-2007-10-110460
https://qmro.qmul.ac.uk/xmlui/handle/123456789/1077
Agrawal SG, Liu FT, Wiseman C, Shirali S, Liu H, Lillington D, Du MQ, Court DS et al. (2007). Bax degradation activity is a novel poor prognosis marker of chronic lymphocytic leukemia. BLOOD. vol. 110, 908A-908A.
10.1182/blood.V110.11.3087.3087
Hao J-H, Yu M, Liu F-T, Newland AC, Jia L(2004). Bcl-2 inhibitors sensitize tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by uncoupling of mitochondrial respiration in human leukemic CEM cells. Cancer Res vol. 64, (10) 3607-3616.
10.1158/0008-5472.CAN-03-3648
Liu F-T, Goff LK, Hao J-H, Newland AC, Jia L(2004). Increase in the ratio of mitochondrial Bax/Bcl-XL induces Bax activation in human leukemic K562 cell line. Apoptosis vol. 9, (3) 377-384.
10.1023/b:appt.0000025815.78761.5c
JIA L, Newland AC, Liu FT, Hao JH, Lindsey KG(2004). Increase in the ratio of mitochondrial Bax/Bcl-XL sensitises leukemic K562 cells to DNA damage-induced apoptosis. Apoptosis vol. 9, 377-384.
Liu F-T, Newland AC, Jia L(2003). Bax conformational change is a crucial step for PUMA-mediated apoptosis in human leukemia. Biochem Biophys Res Commun vol. 310, (3) 956-962.
10.1016/j.bbrc.2003.09.109
Feng WY, Liu FT, Patwari Y, Agrawal SG, Newland AC, Jia L(2003). BH3-domain mimetic compound BH3I-2 ' induces rapid damage to the inner mitochondrial membrane prior to the cytochrome c release from mitochondria. BRIT J HAEMATOL vol. 121, (2) 332-340.
10.1046/j.1365-2141.2003.04268.x
Jia L, Patwari Y, Kelsey SM, Srinivasula SM, Agrawal SG, Alnemri ES, Newland AC(2003). Role of Smac in human leukaemic cell apoptosis and proliferation. ONCOGENE vol. 22, (11) 1589-1599.
10.1038/sj.onc.1206322
Fu WN, Bertoni F, Kelsey SM, McElwaine SM, Cotter FE, Newland AC, Jia L(2003). Role of DNA methylation in the suppression of Apaf-1 protein in human leukaemia. ONCOGENE vol. 22, (3) 451-455.
10.1038/sj.onc.1206147
JIA L, Newland AC, Liu FT, Hao XS, Hao JH(2003). Potential mechanisms of leukemia cell resistance to TRAIL-induced apoptosis. Apoptosis vol. 8, 601-607.
10.1023/A:1026131425204
Liu F-T, Kelsey SM, Newland AC, Jia L(2002). Liposomal encapsulation diminishes daunorubicin-induced generation of reactive oxygen species, depletion of ATP and necrotic cell death in human leukaemic cells. Br J Haematol vol. 117, (2) 333-342.
10.1046/j.1365-2141.2002.03418.x
Liu FT, Kelsey SM, Newland AC, Jia L(2001). Generation of reactive oxygen species is not involved in idarubicin-induced apoptosis in human leukaemic cells. Br J Haematol vol. 115, (4) 817-825.
10.1046/j.1365-2141.2001.03216.x
Partheniou F, Kelsey SM, Srinivasula SM, Newland AC, Alnemri ES, Jia L(2001). c-IAP1 blocks TNFalpha-mediated cytotoxicity upstream of caspase-dependent and -independent mitochondrial events in human leukemic cells. Biochem Biophys Res Commun vol. 287, (1) 181-189.
10.1006/bbrc.2001.5582
Jia L, Patwari Y, Srinivasula SM, Newland AC, Fernandes-Alnemri T, Alnemri ES, Kelsey SM(2001). Bax translocation is crucial for the sensitivity of leukaemic cells to etoposide-induced apoptosis. Oncogene vol. 20, (35) 4817-4826.
10.1038/sj.onc.1204628
Jia L, Srinivasula SM, Liu FT, Newland AC, Fernandes-Alnemri T, Alnemri ES, Kelsey SM(2001). Apaf-1 protein deficiency confers resistance to cytochrome c-dependent apoptosis in human leukemic cells. BLOOD vol. 98, (2) 414-421.
10.1182/blood.V98.2.414
Jia L, Patwari Y, Kelsey SM, Newland AC(2001). Trail-induced apoptosis in Type I leukemic cells is not enhanced by overexpression of bax. Biochem Biophys Res Commun vol. 283, (5) 1037-1045.
10.1006/bbrc.2001.4895
Yin Y, Allen PD, Jia L, Kelsey SM, Newland AC(2001). 8-Cl-adenosine mediated cytotoxicity and sensitization of T-lymphoblastic leukemia cells to TNFalpha-induced apoptosis is via inactivation of NF-kappaB. Leuk Res vol. 25, (5) 423-431.
10.1016/s0145-2126(00)00147-8
Fu WN, Kelsey SM, Newland AC, Jia L(2001). Apaf-1XL is an inactive isoform compared with Apaf-1L. Biochem Biophys Res Commun vol. 282, (1) 268-272.
10.1006/bbrc.2001.4575
Liu KZ, Jia L, Kelsey SM, Newland AC, Mantsch HH(2001). Quantitative determination of apoptosis on leukemia cells by infrared spectroscopy. APOPTOSIS vol. 6, (4) 269-278.
10.1023/a:1011383408381
Yin YZ, Allen PD, JIA L, Macey MG, Kelsey SM, Newland AC(2000). Constitutive levels of cAMP-dependent protein kinase activity determine sensitivity of human multidrug-resistant leukaemic cell lines to growth inhibition and apoptosis by forskolin and tumour necrosis factor alpha. British Journal of Haematology vol. 108, (3) 565-573.
10.1046/j.1365-2141.2000.01903.x
JIA L, Liu KZ, Newland AC, Mantsch HH, Kelsey SM(1999). Pgp-positive leukaemic cells have increased mtDNA but no increased rate of proliferation. British Journal of Haematology vol. 107, (4) 861-869.
10.1046/j.1365-2141.1999.01771.x
JIA L, Macey MG, Yin YZ, Newland AC, Kelsey SM(1999). Subcellular distribution and redistribution of Bcl-2 family proteins in human leukemia cells undergoing apoptosis. Blood vol. 93, (7) 2353-2359.
10.1182/blood.V93.7.2353.407k20_2353_2359
JIA L, Dourmashkin RR, Newland AC, Kelsey SM(1997). Mitochondrial ultracondensation, but not swelling, is involved in TNF alpha-induced apoptosis in human T-lymphoblastic leukaemic cells. Leukemia Research vol. 21, (10) 973-983.
10.1016/s0145-2126(97)00078-7
JIA L, Dourmashkin RR, Allen PD, Gray AB, Newland AC, Kelsey SM(1997). Inhibition of autophagy abrogates tumour necrosis factor alpha induced apoptosis in human T-lymphoblastic leukaemic cells. British Journal of Haematology vol. 98, (3) 673-685.
10.1046/j.1365-2141.1997.2623081.x
JIA L, Allen PD, Macey MG, Grant MF, Newland AC, Kelsey SM(1997). Mitochondrial electron transport chain activity, but not ATP synthesis, is required for drug-induced apoptosis in human leukaemic cells: a possible novel mechanism of regulating drug resistance. British Journal of Haematology vol. 98, (3) 686-698.
10.1046/j.1365-2141.1997.2683085.x
JIA L, Kelsey SM, Grant MF, Jiang XR, Newland AC(1996). Increased activity and sensitivity of mitochondrial respiratory enzymes to tumor necrosis factor alpha-mediated inhibition is associated with increased cytotoxicity in drug-resistant leukemic cell lines. Blood vol. 87, (6) 2401-2410.
Wu YL, Jiang XR, Allen PD, JIA L, Dronfield DM, Newland AC, Kelsey SM(1996). Modulation of surface TNF expression by human leukaemic cells alters their sensitivity to exogenous TNF. Leukemia Research
10.1016/0145-2126(95)00108-5
JIA L, Jiang XR, Razak K, Wu YL, Newland AC, Kelsey SM(1995). TNF-mediated killing of human leukaemic cells: effects of endogenous antioxidant levels and TNF alpha expression in leukaemic cell lines. Leukemia Research vol. 19, (3) 187-194.
10.1016/0145-2126(94)00149-5
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