Publications:  Dr Li Jia

Wang H-Q, Jia L, Li Y-T, Farren T, Agrawal SG, Liu F-T(2019). Increased autocrine interleukin-6 production is significantly associated with worse clinical outcome in patients with chronic lymphocytic leukemia. J Cell Physiol vol. 234, (8) 13994-14006.

Zhang T, Guan X-W, Gribben JG, Liu F-T, Jia L(2019). Blockade of HMGB1 signaling pathway by ethyl pyruvate inhibits tumor growth in diffuse large B-cell lymphoma. Cell Death Dis vol. 10, (5)

Wang P-G, Li Y-T, Pan Y, Gao Z-Z, Guan X-W, Jia L, Liu F-T(2019). Lower expression of Bax predicts poor clinical outcome in patients with glioma after curative resection and radiotherapy/chemotherapy. J Neurooncol vol. 141, (1) 71-81.

Wang X, Dong J, Jia L, Zhao T, Lang M, Li Z, Lan C, Li X et al.(2017). HIF-2-dependent expression of stem cell factor promotes metastasis in hepatocellular carcinoma. Cancer Lett vol. 393, 113-124.

Liu F-T, Jia L, Wang P, Wang H, Farren TW, Agrawal SG(2016). STAT3 and NF-κB cooperatively control <i>in vitro</i> spontaneous apoptosis and poor chemo-responsiveness in patients with chronic lymphocytic leukemia. Oncotarget

Liu F-T, Jia L, Wang P, Farren T, Li H, Hao X, Agrawal SG(2016). CD126 and Targeted Therapy with Tocilizumab in Chronic Lymphocytic Leukemia. Clin Cancer Res vol. 22, (10) 2462-2469.

Wang X, Ren H, Zhao T, Ma W, Dong J, Zhang S, Xin W, Yang S et al.(2016). Single nucleotide polymorphism in the microRNA-199a binding site of HIF1A gene is associated with pancreatic ductal adenocarcinoma risk and worse clinical outcomes. Oncotarget vol. 7, (12) 13717-13729.

Norster F, Clear AJ, Matthews J, Hoxha E, Gribben J, Jia L (2015). Overexpression of HMGB1 Receptor RAGE Is Associated with Worse Clinical Outcome in Patients with Chronic Lymphocytic Leukemia. BLOOD. vol. 126,

Zhao T, Ren H, Wang X, Liu P, Yan F, Jiang W, Li Y, Li J et al.(2015). Rituximab-induced HMGB1 release is associated with inhibition of STAT3 activity in human diffuse large B-cell lymphoma. Oncotarget vol. 6, (29) 27816-27831.

Wang P, Wang P, Liu B, Zhao J, Pang Q, Agrawal SG, Jia L, Liu F-T(2015). Dynamin-related protein Drp1 is required for Bax translocation to mitochondria in response to irradiation-induced apoptosis. Oncotarget vol. 6, (26) 22598-22612.

Zhao T, Ren H, Jia L, Chen J, Xin W, Yan F, Li J, Wang X et al.(2015). Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma. Oncotarget vol. 6, (4) 2250-2262.

McCarthy A, Clear AJ, Marzec J, Coutinho R, Petty RD, Matthews J, Wilson A, Iqbal S et al. (2014). Overexpression of BCL-2 Does Not Inhibit Autophagy in Human Follicular and Diffuse Large B-Cell Lymphomas. BLOOD. vol. 124,

JIA L(2014). Dysregulation of autophagy in human follicular lymphoma is independent of overexpression of BCL-2. Oncotarget11653-11668.

Wang X, Ren H, Zhao T, Chen J, Sun W, Sun Y, Ma W, Wang J et al.(2014). Stem cell factor is a novel independent prognostic biomarker for hepatocellular carcinoma after curative resection. Carcinogenesis vol. 35, (10) 2283-2290.

Jia L, Gribben JG(2014). Dangerous power: mitochondria in CLL cells.

Jia L, Gribben JG(2014). Dangerous power: mitochondria in CLL cells. Blood vol. 123, (17) 2596-2597.

Jia L, Clear A, Liu F-T, Matthews J, Uddin N, McCarthy A, Hoxha E, Durance C et al.(2014). Extracellular HMGB1 promotes differentiation of nurse-like cells in chronic lymphocytic leukemia. Blood vol. 123, (11) 1709-1719.

McCarthy A, Marzec J, Clear A, Petty RD, Coutinho R, Matthews J, Wilson A, Iqbal S et al.(2014). Dysregulation of autophagy in human follicular lymphoma is independent of overexpression of BCL-2. Oncotarget vol. 5, (22) 11653-11668.

Jia L, Liu F-T(2013). Why bortezomib cannot go with 'green'?. Cancer Biol Med vol. 10, (4) 206-213.

Miraki-Moud F, Anjos-Afonso F, Hodby KA, Griessinger E, Rosignoli G, Lillington D, Jia L, Davies JK et al.(2013). Acute myeloid leukemia does not deplete normal hematopoietic stem cells but induces cytopenias by impeding their differentiation. Proc Natl Acad Sci U S A vol. 110, (33) 13576-13581.

McCarthy A, Yeung V, Gribben JG, Jia L (2012). Inhibition of Autophagy by Chloroquine Sensitises Lymphoma Cells to ABT-737-Induced Apoptosis. BLOOD. vol. 120,

JIA L, Gopinathan G, Sukumar JT, Gribben JG(2012). Blocking Autophagy Prevents Bortezomib-Induced NF-kappaB Activation by Reducing I-kappaBalpha Degradation in Lymphoma Cells. PLoS One vol. 7, (2) Article e32584,

Kassam S, Juliger S, Jia L, Joel SP(2012). Methylseleninic acid antagonizes the cytotoxic effect of bortezomib in mantle cell lymphoma cell lines through modulation of Bcl-2 family proteins. Br J Haematol vol. 156, (2) 286-289.

Jia L, Uddin N, Gribben JG (2011). Activation of Mitochondrial STAT3 Increases Mitochondrial Respiration and Inhibits Oxidative Stress in Chronic Lymphocytic Leukemic Cells. BLOOD. vol. 118, 133-133.

Liu F, Jia L, Farren TW, Gribben JG, Agrawal SG (2011). Autocrine IL-6 Production Indicates the Level of Activated STAT3 and NF-Kb of Chronic Lymphocytic Leukemia Cells. BLOOD. vol. 118, 778-778.

Liu FT, Jia L, Farren T, Gribben JG, Agrawal S (2010). Autocrine IL6/STAT3 Signaling Enhances Survival of Chronic Lymphocytic Leukaemia Cells. BLOOD. vol. 116, 1481-1481.

Jia L, Gopinathan G, Sukumar JT, Gribben JG (2010). Potentiation of Bortezomib-Induced Killing of Lymphoma Cells by Inhibition of Autophagy and Prevention of I-kappa B alpha Degradation. BLOOD. vol. 116, 57-57.

Liu F-T, Giustiniani J, Farren T, Jia L, Bensussan A, Gribben JG, Agrawal SG(2010). CD160 signaling mediates PI3K-dependent survival and growth signals in chronic lymphocytic leukemia. Blood vol. 115, (15) 3079-3088.

Agrawal SG, Liu FT, Giustiniani J, Jia L, Gribben JG, Bensussan A (2008). Dual Action of CD160 on CLL Cells: Giving Life to Prepare for Death!. BLOOD. vol. 112, 726-726.

Liu F-T, Agrawal SG, Movasaghi Z, Wyatt PB, Rehman IU, Gribben JG, Newland AC, Jia L(2008). Dietary flavonoids inhibit the anticancer effects of the proteasome inhibitor bortezomib. Blood vol. 112, (9) 3835-3846.

Yu M, Liu F-T, Newland AC, Jia L(2008). The alpha-5 helix of Bax is sensitive to ubiquitin-dependent degradation. Biochem Biophys Res Commun vol. 371, (1) 10-15.

Liu F-T, Agrawal SG, Gribben JG, Ye H, Du M-Q, Newland AC, Jia L(2008). Bortezomib blocks Bax degradation in malignant B cells during treatment with TRAIL. Blood vol. 111, (5) 2797-2805.

Agrawal SG, Liu F-T, Wiseman C, Shirali S, Liu H, Lillington D, Du M-Q, Syndercombe-Court D et al.(2008). Increased proteasomal degradation of Bax is a common feature of poor prognosis chronic lymphocytic leukemia. Blood vol. 111, (5) 2790-2796.

Agrawal SG, Liu FT, Wiseman C, Shirali S, Liu H, Lillington D, Du MQ, Court DS et al. (2007). Bax degradation activity is a novel poor prognosis marker of chronic lymphocytic leukemia. BLOOD. vol. 110, 908A-908A.

Hao J-H, Yu M, Liu F-T, Newland AC, Jia L(2004). Bcl-2 inhibitors sensitize tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by uncoupling of mitochondrial respiration in human leukemic CEM cells. Cancer Res vol. 64, (10) 3607-3616.

Liu F-T, Goff LK, Hao J-H, Newland AC, Jia L(2004). Increase in the ratio of mitochondrial Bax/Bcl-XL induces Bax activation in human leukemic K562 cell line. Apoptosis vol. 9, (3) 377-384.

JIA L, Newland AC, Liu FT, Hao JH, Lindsey KG(2004). Increase in the ratio of mitochondrial Bax/Bcl-XL sensitises leukemic K562 cells to DNA damage-induced apoptosis. Apoptosis vol. 9, 377-384.

Liu F-T, Newland AC, Jia L(2003). Bax conformational change is a crucial step for PUMA-mediated apoptosis in human leukemia. Biochem Biophys Res Commun vol. 310, (3) 956-962.

Feng WY, Liu FT, Patwari Y, Agrawal SG, Newland AC, Jia L(2003). BH3-domain mimetic compound BH3I-2 ' induces rapid damage to the inner mitochondrial membrane prior to the cytochrome c release from mitochondria. BRIT J HAEMATOL vol. 121, (2) 332-340.

Jia L, Patwari Y, Kelsey SM, Srinivasula SM, Agrawal SG, Alnemri ES, Newland AC(2003). Role of Smac in human leukaemic cell apoptosis and proliferation. ONCOGENE vol. 22, (11) 1589-1599.

Fu WN, Bertoni F, Kelsey SM, McElwaine SM, Cotter FE, Newland AC, Jia L(2003). Role of DNA methylation in the suppression of Apaf-1 protein in human leukaemia. ONCOGENE vol. 22, (3) 451-455.

JIA L, Newland AC, Liu FT, Hao XS, Hao JH(2003). Potential mechanisms of leukemia cell resistance to TRAIL-induced apoptosis. Apoptosis vol. 8, 601-607.

Liu F-T, Kelsey SM, Newland AC, Jia L(2002). Liposomal encapsulation diminishes daunorubicin-induced generation of reactive oxygen species, depletion of ATP and necrotic cell death in human leukaemic cells. Br J Haematol vol. 117, (2) 333-342.

Liu FT, Kelsey SM, Newland AC, Jia L(2001). Generation of reactive oxygen species is not involved in idarubicin-induced apoptosis in human leukaemic cells. Br J Haematol vol. 115, (4) 817-825.

Partheniou F, Kelsey SM, Srinivasula SM, Newland AC, Alnemri ES, Jia L(2001). c-IAP1 blocks TNFalpha-mediated cytotoxicity upstream of caspase-dependent and -independent mitochondrial events in human leukemic cells. Biochem Biophys Res Commun vol. 287, (1) 181-189.

Jia L, Patwari Y, Srinivasula SM, Newland AC, Fernandes-Alnemri T, Alnemri ES, Kelsey SM(2001). Bax translocation is crucial for the sensitivity of leukaemic cells to etoposide-induced apoptosis. Oncogene vol. 20, (35) 4817-4826.

Jia L, Srinivasula SM, Liu FT, Newland AC, Fernandes-Alnemri T, Alnemri ES, Kelsey SM(2001). Apaf-1 protein deficiency confers resistance to cytochrome c-dependent apoptosis in human leukemic cells. BLOOD vol. 98, (2) 414-421.

Jia L, Patwari Y, Kelsey SM, Newland AC(2001). Trail-induced apoptosis in Type I leukemic cells is not enhanced by overexpression of bax. Biochem Biophys Res Commun vol. 283, (5) 1037-1045.

Yin Y, Allen PD, Jia L, Kelsey SM, Newland AC(2001). 8-Cl-adenosine mediated cytotoxicity and sensitization of T-lymphoblastic leukemia cells to TNFalpha-induced apoptosis is via inactivation of NF-kappaB. Leuk Res vol. 25, (5) 423-431.

Fu WN, Kelsey SM, Newland AC, Jia L(2001). Apaf-1XL is an inactive isoform compared with Apaf-1L. Biochem Biophys Res Commun vol. 282, (1) 268-272.

Liu KZ, Jia L, Kelsey SM, Newland AC, Mantsch HH(2001). Quantitative determination of apoptosis on leukemia cells by infrared spectroscopy. APOPTOSIS vol. 6, (4) 269-278.

Yin YZ, Allen PD, JIA L, Macey MG, Kelsey SM, Newland AC(2000). Constitutive levels of cAMP-dependent protein kinase activity determine sensitivity of human multidrug-resistant leukaemic cell lines to growth inhibition and apoptosis by forskolin and tumour necrosis factor alpha. British Journal of Haematology vol. 108, (3) 565-573.

JIA L, Liu KZ, Newland AC, Mantsch HH, Kelsey SM(1999). Pgp-positive leukaemic cells have increased mtDNA but no increased rate of proliferation. British Journal of Haematology vol. 107, (4) 861-869.

JIA L, Macey MG, Yin YZ, Newland AC, Kelsey SM(1999). Subcellular distribution and redistribution of Bcl-2 family proteins in human leukemia cells undergoing apoptosis. Blood vol. 93, (7) 2353-2359.

JIA L, Dourmashkin RR, Newland AC, Kelsey SM(1997). Mitochondrial ultracondensation, but not swelling, is involved in TNF alpha-induced apoptosis in human T-lymphoblastic leukaemic cells. Leukemia Research vol. 21, (10) 973-983.

JIA L, Dourmashkin RR, Allen PD, Gray AB, Newland AC, Kelsey SM(1997). Inhibition of autophagy abrogates tumour necrosis factor alpha induced apoptosis in human T-lymphoblastic leukaemic cells. British Journal of Haematology vol. 98, (3) 673-685.

JIA L, Allen PD, Macey MG, Grant MF, Newland AC, Kelsey SM(1997). Mitochondrial electron transport chain activity, but not ATP synthesis, is required for drug-induced apoptosis in human leukaemic cells: a possible novel mechanism of regulating drug resistance. British Journal of Haematology vol. 98, (3) 686-698.

JIA L, Kelsey SM, Grant MF, Jiang XR, Newland AC(1996). Increased activity and sensitivity of mitochondrial respiratory enzymes to tumor necrosis factor alpha-mediated inhibition is associated with increased cytotoxicity in drug-resistant leukemic cell lines. Blood vol. 87, (6) 2401-2410.

Wu YL, Jiang XR, Allen PD, JIA L, Dronfield DM, Newland AC, Kelsey SM(1996). Modulation of surface TNF expression by human leukaemic cells alters their sensitivity to exogenous TNF. Leukemia Research

JIA L, Jiang XR, Razak K, Wu YL, Newland AC, Kelsey SM(1995). TNF-mediated killing of human leukaemic cells: effects of endogenous antioxidant levels and TNF alpha expression in leukaemic cell lines. Leukemia Research vol. 19, (3) 187-194.