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Publications:  Dr Steven Harwood

Dreyer G, Kieswich J, Harwood S, Ahluwalia A, Yaqoob MM(2019). Ergocalciferol improves endothelial vasodilatory and vasoconstrictor function in an in vivo model of mild uraemia. Bioscience Reports vol. 39, (12)
10.1042/BSR20190711
Pile T, Raftery M, Thuraisingham R, Kirwan CJ, Harwood S, Yaqoob MM(2019). Treating Posttransplant Anemia With Erythropoietin Improves Quality of Life but Does Not Affect Progression of Chronic Kidney Disease. Exp Clin Transplant
10.6002/ect.2018.0283
Andrikopoulos P, Kieswich J, Pacheco S, Nadarajah L, Harwood SM, O¿Riordan CE, Thiemermann C, Yaqoob MM(2019). The MEK inhibitor trametinib ameliorates kidney fibrosis by suppressing ERK1/2 and mTORC1 signaling. Journal of the American Society of Nephrology vol. 30, (1) 33-49.
10.1681/ASN.2018020209
https://qmro.qmul.ac.uk/xmlui/handle/123456789/54661
Duraisingham SK, Kieswich JE, Harwood SM, Yaqoob MM (2018). ACUTE WOUND HEALING IN A RODENT MODEL OF UREMIA.
Duraisingham SK, Kieswich JE, Harwood SM, Yaqoob MM (2018). Acute Wound Healing in a Rodent Model of Uremia.
Kieswich J, Sayers SR, Silvestre MF, Harwood SM, Yaqoob MM, Caton PW(2016). Monomeric eNAMPT in the development of experimental diabetes in mice: a potential target for type 2 diabetes treatment. Diabetologia1-10.
10.1007/s00125-016-4076-3
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15826
Chesser AMS, Harwood SM, Raftery MJ, Yaqoob MM(2016). Myocardial bioenergetic abnormalities in experimental uremia. International Journal of Nephrology and Renovascular Disease vol. 9, 129-137.
10.2147/IJNRD.S89926
https://qmro.qmul.ac.uk/xmlui/handle/123456789/18498
Kieswich J, Silvestre M, Harwood SM, Yaqoob MM, Caton PW(2016). Chronic eNAMPT administration induces a diabetic phenotype in mice. DIABETIC MEDICINE vol. 33, 45-46.
Andrikopoulos P, Kieswich J, Harwood SM, Baba A, Matsuda T, Barbeau O, Jones K, Eccles SA et al.(2015). Endothelial angiogenesis and barrier function in response to thrombin require Ca<sup>2+</sup> influx through the Na<sup>+</sup>/Ca<sup>2+</sup>exchanger. Journal of Biological Chemistry vol. 290, (30) 18412-18428.
10.1074/jbc.M114.628156
Kieswich J, Silvestre MP, Harwood SM, Yaqoob MM, Caton PW(2015). Immuno-neutralisation of extracellular nicotinamide phosphoribosyltransferase as a therapeutic strategy for treatment of Type 2 diabetes. DIABETIC MEDICINE vol. 32, 47-47.
White WE, Yaqoob MM, Harwood SM(2015). Aging and uremia: Is there cellular and molecular crossover?. World J Nephrol vol. 4, (1) 19-30.
10.5527/wjn.v4.i1.19
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6968
Gallagher SM, Jones DA, Kapur A, Wragg A, Harwood SM, Mathur R, Archbold RA, Uppal R et al.(2015). Remote ischemic preconditioning has a neutral effect on the incidence of kidney injury after coronary artery bypass graft surgery. Kidney International vol. 87, (2) 473-481.
10.1038/ki.2014.259
Gallagher SM, Jones DA, Kapur A, Wragg A, Harwood SM, Mathur R, Archbold RA, Uppal R et al.(2015). Remote ischemic preconditioning has a neutral effect on the incidence of kidney injury after coronary artery bypass graft surgery. Kidney Int vol. 87, (2) 473-481.
10.1038/ki.2014.259
https://qmro.qmul.ac.uk/xmlui/handle/123456789/9818
Chapagain A, Caton PW, Kieswich J, Andrikopoulos P, Nayuni N, Long JH, Harwood SM, Webster SP et al.(2014). Elevated hepatic 11β-hydroxysteroid dehydrogenase type 1 induces insulin resistance in uremia. Proc Natl Acad Sci U S A vol. 111, (10) 3817-3822.
10.1073/pnas.1312436111
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12518
Dreyer G, Tucker AT, Harwood SM, Pearse RM, Raftery MJ, Yaqoob MM(2014). Ergocalciferol and microcirculatory function in chronic kidney disease and concomitant vitamin d deficiency: an exploratory, double blind, randomised controlled trial. PLoS One vol. 9, (7)
10.1371/journal.pone.0099461
https://qmro.qmul.ac.uk/xmlui/handle/123456789/11484
McCafferty K, Byrne CJ, Kieswich J, Harwood S, Andrikopoulos P, Raftery M, Thiemermann C, Yaqoob MM(2012). Response to letter regarding article, "ischemic conditioning protects the uremic heart in a rodent model of myocardial infarction". Circulation vol. 126, (13)
10.1161/CIRCULATIONAHA.112.130971
Shah S, Harwood SM, Döhler B, Opelz G, Yaqoob MM(2012). Inosine monophosphate dehydrogenase polymorphisms and renal allograft outcome. Transplantation vol. 94, (5) 486-491.
10.1097/TP.0b013e31825b7654
Byrne CJ, McCafferty K, Kieswich J, Harwood S, Andrikopoulos P, Raftery M, Thiemermann C, Yaqoob MM(2012). Ischemic conditioning protects the uremic heart in a rodent model of myocardial infarction. Circulation vol. 125, (10) 1256-1265.
10.1161/CIRCULATIONAHA.111.055392
Nandra KK, Patel NS, Harwood S, Collino M, Rogazzo M, Yaqoob M, Thiemermann C (2012). THREE DAY PRE-TREATMENT WITH ERYTHROPOIETIN ATTENUATES THE ORGAN INJURY AND DYSFUNCTION INDUCED BY HEMORRHAGIC SHOCK IN THE RAT BY A MECHANISM INDEPENDENT OF ENDOTHELIAL PROGENITOR CELL MOBILISATION. SHOCK. vol. 37, 96-97.
Pile T, Kieswich J, Harwood S, Yaqoob MM(2011). A possible explanation for anemia in patients treated with mycophenolic acid. Transplantation vol. 92, (12) 1316-1321.
10.1097/TP.0b013e318238da98
Qureshi AC, Rampat R, Harwood S, Roughton M, Yaqoob MM, Kapur A (2011). Urine NGAL and IL-18 Identify CI-AKI Early in Patients with DM and CKD Undergoing Coronary Angiography/PCI. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. vol. 58, B26-B27.
Qureshi A, Rampat R, Harwood SM, Roughton M, Yaqoob MM, Kapur A(2011). A combination of urine NGAL and IL-18 identifies contrast induced nephropathy early in patients with diabetes and CKD undergoing coronary angiography and PCI. EUROPEAN HEART JOURNAL vol. 32, 92-92.
Qureshi AC, Rampat R, Harwood SM, Roughton M, Yaqoob MM, Kapur A (2011). SERUM NGAL IDENTIFIES CONTRAST NEPHROPATHY EARLY IN PATIENTS WITH DIABETES MELLITUS AND CHRONIC KIDNEY DISEASE UNDERGOING CORONARY ANGIOGRAPHY AND ANGIOPLASTY. HEART. vol. 97, A17-A18.
10.1136/heartjnl-2011-300198.23
Kumar S, Allen DA, Kieswich JE, Patel NSA, Harwood S, Mazzon E, Cuzzocrea S, Raftery MJ et al.(2009). Dexamethasone ameliorates renal ischemia-reperfusion injury. J Am Soc Nephrol vol. 20, (11) 2412-2425.
10.1681/ASN.2008080868
Harwood SM, Allen DA, Raftery MJ, Yaqoob MM(2007). High glucose initiates calpain-induced necrosis before apoptosis in LLC-PK1 cells. Kidney Int vol. 71, (7) 655-663.
10.1038/sj.ki.5002106
Allen DA, Yaqoob MM, Harwood SM(2005). Mechanisms of high glucose-induced apoptosis and its relationship to diabetic complications. J Nutr Biochem vol. 16, (12) 705-713.
10.1016/j.jnutbio.2005.06.007
Harwood SM, Yaqoob MM, Allen DA(2005). Caspase and calpain function in cell death: bridging the gap between apoptosis and necrosis. Ann Clin Biochem vol. 42, (Pt 6) 415-431.
10.1258/000456305774538238
Harwood S, Yaqoob MM(2005). Ouabain-induced cell signaling. Front Biosci vol. 10, 2011-2017.
10.2741/1676
Ashman N, Harwood SM, Kieswich J, Allen DA, Roberts NB, Mendes-Ribeiro AC, Yaqoob MM(2005). Albumin stimulates cell growth, L-arginine transport, and metabolism to polyamines in human proximal tubular cells. KIDNEY INT vol. 67, (5) 1878-1889.
10.1111/j.1523-1755.2005.00286.x
THIEMERMANN C, Yaqoob MM, Raftery M, Harwood S, Allen D, Mota-Philipe H, Brown P, Sharples EJ et al.(2004). Erythropoietin Protects the Kidney against the Injury and Dysfunction Caused by Ischemia-Reperfusion. Journal American Society of Nephrology vol. 15, 2115-2124.
10.1097/01.ASN.0000135059.67385.5D
Steddon SJ, Harwood SM, Allen DA, Burrin JM, Cunningham J, Yaqoob MM (2003). Calpain activation is concurrent with caspase-3 suppression in IGF-I treated human osteoblastic cells. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. vol. 14, 467A-467A.
Allen DA, Harwood SM, Raftery MJ, Yaqoob MM (2003). Calpain: A mediator of high glucose-induced necrosis and apoptosis in proximal tubular epithelial cells. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. vol. 14, 387A-387A.
Sharples EJ, Patel N, Brown P, Stewart K, Mota-Philipe H, Sheaff M, Allen DA, Harwood SM et al. (2003). Erythropoietin protects the kidney against the injury and dysfunction caused by ischemia-reperfusion injury by the inhibition of the caspase cascade and apoptosis. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. vol. 14, 273A-273A.
Harwood SM, Allen DA, Raftery MJ, Yaqoob MM (2003). Low ouabain concentrations stimulate calpain activity in multiple cell lines. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. vol. 14, 339A-339A.
Ashman N, Harwood SM, Kieskiewicz J, Ribeiro CM, Raftery MJ, Yaqoob MM (2003). Recombinant human albumin (rHSA) stimulates cell growth, L-arginine transport and metabolism to polyamines in human proximal tubular cells independent of PI-3 kinase inhibition. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. vol. 14, 341A-341A.
Harwood SM, Allen DA, Raftery MJ, Yaqoob MM(2003). Calpain is a mediator of myocardial injury in experimental uremia: is it activated by endogenous ouabain?. Kidney Int Suppl (84) S177-S180.
10.1046/j.1523-1755.63.s84.48.x
Allen DA, Harwood S, Varagunam M, Raftery MJ, Yaqoob MM(2003). High glucose-induced oxidative stress causes apoptosis in proximal tubular epithelial cells and is mediated by multiple caspases. FASEB J vol. 17, (8) 908-910.
10.1096/fj.02-0130fje
Harwood SM, Allen DA, Chesser AMS, New DI, Raftery MJ, Yaqoob MM(2003). Calpain is activated in experimental uremia: is calpain a mediator of uremia-induced myocardial injury?. Kidney Int vol. 63, (3) 866-877.
10.1046/j.1523-1755.2003.00823.x
Allen DA, Harwood SM, Varagunam M, Raftery MJ, Yaqoob MM(2003). High glucose-induced oxidative stress causes apoptosis in proximal tubular epithelial cells and is mediated by multiple caspases. FASEB J vol. 17, (3) 908-+.
10.1096/fj.02.0130fje
Harwood S, Mullen AM, McMahon AC, Dawnay A(2001). Plasma OLC is elevated in mild experimental uremia but is not associated with hypertension. AM J HYPERTENS vol. 14, (11) 1112-1115.
10.1016/s0895-7061(01)02219-1
THIEMERMANN C, Yaqoob MM, McDonald MC, Chatterjee PK, Harwood S, Plevin R, Mota-Filipe H, Paul A et al.(2001). Calpain inhibitor I reduces the activation of nuclear factor-kappaB and organ injury/dysfunction in hemorrhagic shock. FASEB Journal vol. 15, (1) 171-186.
10.1096/fj.99-0645com
Harwood S, Alfazema L, Perrett D, Dawnay A (2000). Analysis of human ouabainlike compound by micellar electrokinetic chromatography. HYPERTENSION RESEARCH. vol. 23, S29-S32.
10.1291/hypres.23.Supplement_S29
Hinson JP, Harwood S, Dawnay AB(1998). Release of ouabain-like compound (OLC) from the intact perfused rat adrenal gland. Endocr Res vol. 24, (3-4) 721-724.
10.3109/07435809809032675
Lipkin GW, Thuraisingham R, Dawnay AB, Harwood SM, Raine AE(1997). Acute reversal of cyclosporine nephrotoxicity by neutral endopeptidase inhibition in stable renal transplant recipients. Transplantation vol. 64, (7) 1007-1017.
10.1097/00007890-199710150-00013
Lipkin GW, Dawnay ABS, Harwood SM, Cattell WR, Raine AEG(1997). Enhanced natriuretic response to neutral endopeptidase inhibition in patients with moderate chronic renal failure. KIDNEY INTERNATIONAL vol. 52, (3) 792-801.
10.1038/ki.1997.396
Harwood S, Little JA, Gallacher G, Perrett D, Edwards R, Dawnay A(1997). Development of enzyme immunoassay for endogenous ouabain-like compound in human plasma. CLINICAL CHEMISTRY vol. 43, (5) 715-722.
LAMB EJ, WORRALL J, BUHLER R, HARWOOD S, CATTELL WR, DAWNAY AB(1995). EFFECT OF DIABETES AND PERITONITIS ON THE PERITONEAL EQUILIBRATION TEST. KIDNEY INTERNATIONAL vol. 47, (6) 1760-1767.
10.1038/ki.1995.243
LIPKIN GW, DAVIES S, HARWOOD SM, TOMSON CRV, DAWNAY ABS, RAINE AEG(1994). CHRONIC NEUTRAL ENDOPEPTIDASE (NEP) INHIBITION ACCELERATES THE PROGRESSION OF EXPERIMENTAL CHRONIC-RENAL-FAILURE (CRF). JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY vol. 5, (3) 949-949.
DAWNAY A, WORRALL J, HARWOOD S, RAINE A(1994). EFFECT OF DIABETES AND HYPERGLYCEMIA ON SOLUTE TRANSPORT AND ULTRAFILTRATION IN CAPD. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY vol. 5, (3) 513-513.
LIPKIN GW, DAWNAY ABS, HARWOOD SM, KENDALL RG, CATTELL WR, RAINE AEG(1992). RENAL HEMODYNAMIC, HORMONAL AND EXCRETORY EFFECTS OF LOW-DOSE ATRIAL-NATRIURETIC-FACTOR INFUSION IN RENAL-TRANSPLANT RECIPIENTS. CLINICAL SCIENCE vol. 82, (2) 119-126.
10.1042/cs0820119
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