Publications: Prof Charles Hinds

Antcliffe DB, Mi Y, Santhakumaran S, Burnham KL, Prevost AT, Ward JK, Marshall TJ, Bradley C et al. ( 2024 ) . Patient stratification using plasma cytokines and their regulators in sepsis: relationship to outcomes, treatment effect and leucocyte transcriptomic subphenotypes . Thorax vol. 79 , ( 6 ) 515 - 523 .

Torrance HD, Zhang P, Longbottom ER, Mi Y, Whalley JP, Allcock A, Kwok AJ, Cano-Gamez E et al. ( 2023 ) . A Transcriptomic Approach to Understand Patient Susceptibility to Pneumonia After Abdominal Surgery . Annals of Surgery vol. 279 , ( 3 ) 510 - 520 .

Kwok AJ, Allcock A, Ferreira RC, Cano-Gamez E, Smee M, Burnham KL, Zurke Y-X, McKechnie S et al. ( 2023 ) . Neutrophils and emergency granulopoiesis drive immune suppression and an extreme response endotype during sepsis . Nature Immunology vol. 24 , ( 5 ) 767 - 779 .

Cano-Gamez E, Burnham KL, Goh C, Allcock A, Malick ZH, Overend L, Kwok A, Smith DA et al. ( 2022 ) . An immune dysfunction score for stratification of patients with acute infection based on whole-blood gene expression . Science Translational Medicine vol. 14 , ( 669 ) eabq4433 - eabq4433 .

Baillie JK, Begg C, Clohisey Hendry S, Hinds C, Horby P, Knight J, Ling L, Maslove D et al. ( 2022 ) . Whole-genome sequencing reveals host factors underlying critical COVID-19 . Nature vol. 607 , ( 7917 ) 97 - 103 .

Consortium CM-OBA, Ahern DJ, Ai Z, Ainsworth M, Allan C, Allcock A, Angus B, Ansari MA et al. ( 2022 ) . A blood atlas of COVID-19 defines hallmarks of disease severity and specificity . Cell vol. 185 , ( 5 ) 916 - 938.e58 .

Milind N, Burnham KL, Lee W, Mi Y, Goh C, Hinds CJ, Knight JC, Davenport EE ( 2022 ) . Multi-omics integration to characterise mechanisms of molecular QTL from a sepsis cohort . HUMAN HEREDITY . vol. VOL. , 6 - 6 .

Niemi MEK, Karjalainen J, Liao RG, Neale BM, Daly M, Ganna A, Davis L, Lee S et al. ( 2021 ) . Mapping the human genetic architecture of COVID-19 . Nature vol. 600 , ( 7889 ) 472 - 477 .

Pairo-Castineira E, Clohisey S, Klaric L, Bretherick AD, Rawlik K, Pasko D, Walker S, Parkinson N et al. ( 2020 ) . Genetic mechanisms of critical illness in COVID-19 . Nature vol. 591 , ( 7848 ) 92 - 98 .

Smith A, Edlin J, Hinds C, Ambekar S ( 2020 ) . Coronary revascularisation in cardiac amyloidosis . Journal of Cardiac Surgery vol. 35 , ( 11 ) 3248 - 3250 .

Goh C, Burnham KL, Ansari MA, de Cesare M, Golubchik T, Hutton P, Overend LE, Davenport EE et al. ( 2020 ) . Epstein-Barr virus reactivation in sepsis due to community-acquired pneumonia is associated with increased morbidity and an immunosuppressed host transcriptomic endotype . Scientific Reports vol. 10 , ( 1 )

Bangash MN, Abbott TEF, Patel NSA, Hinds C, Thiemermann C, Pearse R ( 2020 ) . The Effect of β2-Adrenoceptor Agonists on Leucocyte-Endothelial Adhesion in a Rodent Model of Laparotomy and Endotoxemia . Frontiers in Immunology vol. 11 ,

Tridente A, Holloway PAH, Hutton P, Gordon AC, Mills GH, Clarke GM, Chiche J-D, Stuber F et al. ( 2019 ) . Methodological challenges in European ethics approvals for a genetic epidemiology study in critically ill patients: the GenOSept experience . BMC Medical Ethics vol. 20 , ( 1 )

Antcliffe DB, Burnham KL, Al-Beidh F, Santhakumaran S, Brett SJ, Hinds CJ, Ashby D, Knight JC et al. ( 2019 ) . Transcriptomic Signatures in Sepsis and a Differential Response to Steroids. From the VANISH Randomized Trial . American Journal of Respiratory and Critical Care Medicine vol. 199 , ( 8 ) 980 - 986 .

TORRANCE H, LONGBOTTOM R, VIVIAN M, Lalabekyan B, ABBOTT TEF, ACKLAND GL, HINDS CJ, PEARSE RM et al. ( 2018 ) . Post-operative immune suppression is mediated via reversible, Interleukin-10 dependent pathways in circulating monocytes following major abdominal surgery . PLoS ONE vol. 13 , ( 9 )

Jones TF, Torrance HDT, Owen HC, Brohi K, Barnes MR, Knight JC, Hinds CJ, Ackland GL et al. ( 2018 ) . MicroRNA profiles are associated with lymphocyte count after a major traumatic injury: a potential role for immunometabolism? . British Journal of Anaesthesia vol. 121 , ( 2 ) e23 - e24 .

Lashin HMS, Nadkarni S, Oggero S, Jones HR, Knight JC, Hinds CJ, Perretti M ( 2018 ) . Microvesicle Subsets in Sepsis Due to Community Acquired Pneumonia Compared to Faecal Peritonitis . Shock vol. 49 , ( 4 ) 393 - 401 .

Sweeney TE, Perumal TM, Henao R, Nichols M, Howrylak JA, Choi AM, Bermejo-Martin JF, Almansa R et al. ( 2018 ) . A community approach to mortality prediction in sepsis via gene expression analysis . Nature Communications vol. 9 , ( 1 )

Annane D, Mira J-P, Ware LB, Gordon AC, Hinds CJ, Christiani DC, Sevransky J, Barnes K et al. ( 2018 ) . Pharmacogenomic biomarkers do not predict response to drotrecogin alfa in patients with severe sepsis . Annals of Intensive Care vol. 8 , ( 1 )

Tridente A, Bion J, Mills GH, Gordon AC, Clarke GM, Walden A, Hutton P, Holloway PAH et al. ( 2017 ) . Derivation and validation of a prognostic model for postoperative risk stratification of critically ill patients with faecal peritonitis . Annals of Intensive Care vol. 7 , ( 1 )

Scicluna BP, van Vught LA, Zwinderman AH, Wiewel MA, Davenport EE, Burnham KL, Nürnberg P, Schultz MJ et al. ( 2017 ) . Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study . The Lancet Respiratory Medicine vol. 5 , ( 10 ) 816 - 826 .

Burnham KL, Davenport EE, Radhakrishnan J, Humburg P, Gordon AC, Hutton P, Svoren-Jabalera E, Garrard C et al. ( 2016 ) . Shared and Distinct Aspects of the Sepsis Transcriptomic Response to Fecal Peritonitis and Pneumonia . American Journal of Respiratory and Critical Care Medicine vol. 196 , ( 3 ) 328 - 339 .

Bos L, Schouten L, van Vught L, Wiewel M, Ong D, Cremer O, Artigas A, Martin-Loeches I et al. ( 2016 ) . ESICM LIVES 2016: part one . Intensive Care Medicine Experimental vol. 4 , ( Suppl 1 )

Scherag A, Schöneweck F, Kesselmeier M, Taudien S, Platzer M, Felder M, Sponholz C, Rautanen A et al. ( 2016 ) . Genetic Factors of the Disease Course after Sepsis: A Genome-Wide Study for 28Day Mortality . EBioMedicine vol. 12 , 239 - 246 .

Sivakumar S, Taccone FS, Desai KA, Lazaridis C, Skarzynski M, Sekhon M, Henderson W, Griesdale D et al. ( 2016 ) . ESICM LIVES 2016: part two : Milan, Italy. 1-5 October 2016 . Intensive Care Med Exp . Conference: ESICM Lives 2016 ( Germany ) vol. 4 , 30 - 30 .

Longbottom ER, Torrance HDT, Owen HC, Fragkou PC, Hinds CJ, Pearse RM, O’Dwyer MJ ( 2016 ) . Features of Postoperative Immune Suppression Are Reversible With Interferon Gamma and Independent of Interleukin-6 Pathways . Annals of Surgery vol. 264 , ( 2 ) 370 - 377 .

Davenport EE, Burnham KL, Radhakrishnan J, Humburg P, Hutton P, Mills TC, Rautanen A, Gordon AC et al. ( 2016 ) . Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study . The Lancet Respiratory Medicine vol. 4 , ( 4 ) 259 - 271 .

Tridente A, Clarke GM, Walden A, Gordon AC, Hutton P, Chiche J-D, Holloway PA, Mills GH et al. ( 2015 ) . Association between trends in clinical variables and outcome in intensive care patients with faecal peritonitis: analysis of the GenOSept cohort . Critical Care vol. 19 , ( 1 )

Owen HC, Torrance HDT, Jones TF, Pearse RM, Hinds CJ, Brohi K, O’Dwyer MJ ( 2015 ) . Epigenetic regulatory pathways involving microRNAs may modulate the host immune response following major trauma . Journal of Trauma and Acute Care Surgery vol. 79 , ( 5 ) 766 - 772 .

Raja M, Torrance H, Longbottom E, Stroud A, Vivian M, Zolfaghari P, Pearse R, Hinds C et al. ( 2015 ) . Long-Term Follow-Up of Sepsis Induced Immunoparalysis . Intensive Care Medicine Experimental vol. 3 , ( Suppl 1 )

Longbottom E, Torrance H, Owen H, Hinds C, Pearse R, O'Dwyer M ( 2015 ) . Post-operative immune suppression is reversible with interferon gamma and independent of IL-6 pathways . Intensive Care Medicine Experimental vol. 3 , ( Suppl 1 )

Torrance H, Brohi K, Warnes G, Owen H, Hinds C, Pennington D, O'Dwyer M ( 2015 ) . T-helper cell polarisation following severe polytrauma . Intensive Care Medicine Experimental vol. 3 , ( Suppl 1 )

Owen H, Torrance H, Barnes M, Brohi K, Knight J, Hinds C, O'Dwyer M ( 2015 ) . The Role of Micrornas in The Development of Hospital Acquired Infection in Polytrauma Patients . Intensive Care Medicine Experimental vol. 3 , ( Suppl 1 )

Jones TF, Owen HC, Torrance HD, Pirmadjid N, Brohi K, Hinds CJ, O'Dwyer MJ ( 2015 ) . MicroRNA-mediated regulation of IL-10, IL-12 and TNFα gene expression in severely injured trauma patients . Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine . vol. 23 ,

Rautanen A, Chapman SJ, Hinds CJ ( 2015 ) . Response to Schöneweck et al.: Common genomic variation in the FER gene: useful to stratify patients with sepsis due to pneumonia? . Intensive Care Medicine vol. 41 , ( 7 ) 1382 - 1382 .

Mills TC, Chapman S, Hutton P, Gordon AC, Bion J, Chiche J-D, Holloway PAH, Stüber F et al. ( 2015 ) . Variants in the Mannose-binding Lectin Gene MBL2 do not Associate With Sepsis Susceptibility or Survival in a Large European Cohort . Clinical Infectious Diseases vol. 61 , ( 5 ) 695 - 703 .

Torrance HD, Brohi K, Pearse RM, Mein CA, Wozniak E, Prowle JR, Hinds CJ, O'Dwyer MJ ( 2015 ) . Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured polytrauma patients . Annals of Surgery vol. 261 , ( 4 ) 751 - 759 .

Torrance HD, Brohi K, Pearse RM, Mein CA, Wozniak E, Prowle JR, Hinds CJ, OʼDwyer MJ ( 2015 ) . Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured polytrauma patients . Ann Surg vol. 261 , ( 4 ) 751 - 759 .

Tridente A, Clarke G, Walden A, Gordon A, Hutton P, Chiche J, Holloway P, Mills G et al. ( 2015 ) . Phenotypic factors associated with outcome in 977 intensive care patients with faecal peritonitis: analysis of trends in the GenOSept cohort . Critical Care vol. 19 , ( Suppl 1 )

Torrance HD, Vivian ME, Brohi K, Prowle JR, Pearse RM, Owen HC, Hinds CJ, O'Dwyer MJ ( 2015 ) . Changes in gene expression following trauma are related to the age of transfused packed red blood cells . J Trauma Acute Care Surg vol. 78 , ( 3 ) 535 - 542 .

Rautanen A, Mills TC, Gordon AC, Hutton P, Steffens M, Nuamah R, Chiche J-D, Parks T et al. ( 2014 ) . Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study . The Lancet Respiratory Medicine vol. 3 , ( 1 ) 53 - 60 .

MacDonald N, Ahmad T, Mohr O, Kirk-Bayley J, Moppett I, Hinds CJ, Pearse RM ( 2014 ) . Dynamic preload markers to predict fluid responsiveness during and after major gastrointestinal surgery: an observational substudy of the OPTIMISE trial . British Journal of Anaesthesia vol. 114 , ( 4 ) 598 - 604 .

Owen H, Torrance H, Brohi K, Hinds C, O'Dwyer M ( 2014 ) . 1068. MicroRNA-regulated immunosuppression in severely injured polytrauma patients . Intensive Care Medicine Experimental vol. 2 , ( Suppl 1 )

Torrance HD, Brohi K, Pearse RM, Mein CA, Wozniak E, Prowle JR, Hinds CJ, O’Dwyer MJ ( 2014 ) . Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured polytrauma patients . Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine . vol. 22 ,

Pearse RM, Harrison DA, MacDonald N, Gillies MA, Blunt M, Ackland G, Grocott MPW, Ahern A et al. ( 2014 ) . Effect of a perioperative, cardiac output-guided hemodynamic therapy algorithm on outcomes following major gastrointestinal surgery: a randomized clinical trial and systematic review . JAMA vol. 311 , ( 21 ) 2181 - 2190 .

Fragkou P, Torrance H, Ackland G, Hinds C, Pearse R, O'Dwyer MJ ( 2014 ) . Major gastrointestinal surgery is associated with a specific gene expression profile that is quantitatively associated with infectious complications . European Journal of Anaesthesiology . vol. 31 ,

Fragkou P, Prowle J, Ackland G, Hinds C, Pearse R, O'Dwyer MJ ( 2014 ) . Perioperative blood transfusion is associated with a characteristic immune response, excess infectious complications and death in patients undergoing scheduled major gastrointestinal surgery . European Journal of Anaesthesiology . vol. 31 ,

O'Leary MJ, Quinton N, Ferguson CN, Preedy VR, Ross RJM, Hinds CJ ( 2014 ) . In rats with sepsis, the acute fall in IGF-I is associated with an increase in circulating growth hormone-binding protein levels . Intensive Care Medicine vol. 26 , ( 10 ) 1547 - 1552 .

Mills TC, Rautanen A, Elliott KS, Parks T, Naranbhai V, Ieven MM, Butler CC, Little P et al. ( 2014 ) . <i>IFITM3</i> and Susceptibility to Respiratory Viral Infections in the Community . JOURNAL OF INFECTIOUS DISEASES vol. 209 , ( 7 ) 1028 - 1031 .

Lashin H, Nadkarni S, Hinds C, Perretti M ( 2014 ) . IN PATIENTS WITH SEVERE SEPSIS MICROPARTICLE PROFILES DIFFER ACCORDING TO THE SOURCE OF INFECTION . INTENSIVE CARE MEDICINE . vol. 40 , S239 - S240 .

Dalli J, Norling LV, Montero-Melendez T, Federici Canova D, Lashin H, Pavlov AM, Sukhorukov GB, Hinds CJ et al. ( 2014 ) . Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis . EMBO Mol Med vol. 6 , ( 1 ) 27 - 42 .

Walden AP, Clarke GM, McKechnie S, Hutton P, Gordon AC, Rello J, Chiche J-D, Stueber F et al. ( 2014 ) . Patients with community acquired pneumonia admitted to European intensive care units: an epidemiological survey of the GenOSept cohort . CRITICAL CARE vol. 18 , ( 2 ) Article ARTN R58 ,

Tridente A, Clarke GM, Walden A, McKechnie S, Hutton P, Mills GH, Gordon AC, Holloway PAH et al. ( 2014 ) . Patients with faecal peritonitis admitted to European intensive care units: an epidemiological survey of the GenOSept cohort . INTENSIVE CARE MEDICINE vol. 40 , ( 2 ) 202 - 210 .

Fragkou PC, Torrance HD, Pearse RM, Ackland GL, Prowle JR, Owen HC, Hinds CJ, O'Dwyer MJ ( 2014 ) . Perioperative blood transfusion is associated with a gene transcription profile characteristic of immunosuppression: a prospective cohort study . Crit Care vol. 18 , ( 5 ) 014 - 0541 .

Vivian M, Torrance HDT, Pearse R, Brohi K, Hinds CJ, O'Dwyer MJ ( 2014 ) . THE AGE OF TRANSFUSED PACKED RED BLOOD CELLS CORRELATES WITH THE DEGREE OF IMMUNOSUPPRESSION AS ASSESSED BY GENE EXPRESSION PATTERNS IN SEVERELY INJURED TRAUMA PATIENTS . INTENSIVE CARE MEDICINE . vol. 40 , S20 - S20 .

Dalli J, Montero-Melendez T, Norling LV, Yin X, Hinds C, Haskard D, Mayr M, Perretti M ( 2013 ) . Heterogeneity in neutrophil microparticles reveals distinct proteome and functional properties . Mol Cell Proteomics vol. 12 , ( 8 ) 2205 - 2219 .

Bangash MN, Patel NSA, Benetti E, Collino M, Hinds CJ, Thiemermann C, Pearse RM ( 2013 ) . Dopexamine can attenuate the inflammatory response and protect against organ injury in the absence of significant effects on hemodynamics or regional microvascular flow . Crit Care vol. 17 , ( 2 )

Torrance H, Brohi K, Hinds C, O'Dwyer M ( 2013 ) . Cytokine gene expression can predict infectious complications following severe trauma . Critical Care vol. 17 , ( Suppl 2 )

Torrance HDT, Brohi K, Pearse RM, Fragkou P, Hinds CJ, O'Dwyer MJ ( 2013 ) . BLOOD TRANSFUSION FOLLOWING SEVERE TRAUMA IS ASSOCIATED WITH THE DEVELOPMENT OF AN EARLY ANTI-INFLAMMATORY RESPONSE . INTENSIVE CARE MEDICINE . vol. 39 , S386 - S387 .

Perretti M, Dalli J, Norling LV, Montero-Melendez T, Hinds C ( 2013 ) . Neutrophil Microparticles are heterogenous in content and function . FASEB JOURNAL . vol. 27 ,

Evans SF, Hinds CJ, Varley JG ( 2012 ) . A new canine model of endotoxin shock . British Journal of Pharmacology vol. 83 , ( 2 ) 433 - 442 .

Evans SF, Hinds CJ, Varley JG ( 2012 ) . Effects of intravascular volume expansion on the cardiovascular response to naloxone in a canine model of severe endotoxin shock . British Journal of Pharmacology vol. 83 , ( 2 ) 443 - 448 .

Ghosh IR, Kennedy DD, Fletcher SN, Misra VP, Coakley JH, Hinds CJ ( 2011 ) . Identical persisting neurophysiological features of chronic denervation found in four cases of resolved critical illness motor syndrome . Clinical Intensive Care vol. 12 , ( 5-6 ) 229 - 236 .

Myers K, Hajek P, Hinds C, McRobbie H ( 2011 ) . Stopping smoking shortly before surgery and postoperative complications: a systematic review and meta-analysis . Arch Intern Med vol. 171 , ( 11 ) 983 - 989 .

Radhakrishinan J, Svoren EM, Ellis P, Langford C, Huttor P, Davenport E, Thorpe A, Gerrard C et al. ( 2011 ) . A FUNCTIONAL GENOMICS APPROACH TO THE IDENTIFICATION OF BR :MARKERS OF SURVIVAL IN SEVERE SEPSIS DUE TO COMMUNITY ACQUIRED PNEUMONIA . INTENSIVE CARE MEDICINE . vol. 37 , S200 - S200 .

Tridente A, Clarke GM, Walden A, McKechnie SR, Hutton P, Martynoga R, Mills GH, Gordon AC et al. ( 2011 ) . EPIDEMIOLOGY OF FAECAL PERITONITIS IN THE GENOSEPT COHORT . INTENSIVE CARE MEDICINE . vol. 37 , S199 - S199 .

Svoren EM, Radhakrisnan J, Ellis P, Langford C, Mcalees E, Knight J, Hinds CJ ( 2011 ) . GLOBAL GENE EXPRESSION PROFILING REVEALS KEY PATHWAYS ASSOCIATED WITH THE HOST RESPONSE TO CARDIAC SURGERY AND CARDIOPULMONARY BYPASS . INTENSIVE CARE MEDICINE . vol. 37 , S12 - S12 .

Walden AP, Clarke G, McKechnie S, Hutton P, Stueber F, Hinds C, Garrard C, GenOSept ( 2010 ) . EPIDEMIOLOGY OF COMMUNITY ACQUIRED PENUMONIA IN THE GENOSEPT COHORT . INTENSIVE CARE MEDICINE . vol. 36 , S231 - S231 .

Jhanji S, Vivian-Smith A, Lucena-Amaro S, Watson D, Hinds CH, Pearse RM ( 2010 ) . A randomised controlled trial of the effects of three haemodynamic therapies on microvascular flow, tissue oxygenation and inflammatory markers after major abdominal surgery . Journal of the Intensive Care Society . Conference: The Intensive Care Society State of the Art Meeting ( London ) from: 14/12/2009 to: 15/12/2009 , vol. 11 , 60 - 60 .

Bangash MN, Patel NS, Hinds CJ, Lever R, Thiemermann C, Pearse RM ( 2010 ) . Dose-dependent effects of dopexamine on indices of shock and organ dysfunction in a rodent model of laparotomy and endoxaemia . http://journal.ics.ac.uk/pdf/1101054.pdf . Conference: The Intensive Care Society State of the Art Meeting ( London ) from: 14/12/2009 to: 15/12/2009 , vol. 11 , 64 - 64 .

Radhakrishnan J, Svoren E, Ellis P, Langford C, Hutton P, Garrard C, Hinds CJ, Knight J et al. ( 2010 ) . Evolution of gene expression signatures in septic shock due to community-acquired pneumonia . http://www.ics.ac.uk/Meetings_Seminars/ics_past_events/complete_soa09_delegate_handbook . Conference: The Intensive Care Society State of The Art Meeting ( London ) from: 14/12/2009 to: 14/12/2010 , vol. 11 , 60 - 60 .

Jhanji S, Vivian-Smith A, Lucena-Amaro S, Watson D, Hinds CJ, Pearse RM ( 2010 ) . Haemodynamic optimisation improves tissue microvascular flow and oxygenation after major surgery: a randomised controlled trial . Crit Care vol. 14 , ( 4 )

Svoren E, Radhakrishnan J, Ellis P, Langford C, Knight JC, Hinds CJ ( 2010 ) . Sequential gene expression profiles following cardiac surgery involving cardiopulmonary bypass . http://www.ics.ac.uk/Meetings_Seminars/ics_past_events/complete_soa09_delegate_handbook . Conference: The Intensive Care Society State of the Art Meeting ( London ) from: 14/12/2009 to: 15/12/2009 , vol. 11 , 67 - 67 .

Pearse R, Bennett D, Hinds C ( 2009 ) . Dopexamine and survival: areas of consistency . Anaesthesia vol. 64 , ( 11 ) 1258 - 1258 .

Jhanji S, Vivian-Smith A, Lucena-Amaro S, Watson D, Hinds CJ, Pearse RM ( 2009 ) . A RANDOMISED CONTROLLED TRIAL OF THE EFFECTS OF POST-OPERATIVE HAEMODYNAMIC OPTIMISATION ON MICROVASCULAR FLOW, TISSUE OXYGENATION AND INFLAMMATORY MARKERS AFTER MAJOR ABDOMINAL SURGERY . INTENSIVE CARE MEDICINE . vol. 35 , 213 - 213 .

Hinds CJ, Watson D ( 2009 ) . Intensive Care Medicine . Kumar & Clark's clinical medicine , Editors: Kumar, P, Clark, ML , Saunders Ltd

Jhanji S, Stirling S, Patel N, Hinds CJ, Pearse RM ( 2009 ) . The effect of increasing doses of norepinephrine on tissue oxygenation and microvascular flow in patients with septic shock . Crit Care Med vol. 37 , ( 6 ) 1961 - 1966 .

Jhanji S, Lee C, Watson D, Hinds C, Pearse RM ( 2009 ) . Microvascular flow and tissue oxygenation after major abdominal surgery: association with post-operative complications . Intensive Care Med vol. 35 , ( 4 ) 671 - 677 .

Jhanji S, Lee C, Watson D, Hinds CJ, Pearse RM ( 2009 ) . Alterations in microvascular flow and tissue oxygenation after major abdominal surgery . Intensive Care Medicine . Conference: The Intensive Care Society State of the Art Meeting ( London ) from: 15/12/2008 to: 16/12/2008 , vol. 35 , 671 - 677 .

Maddison B, Wolff C, Findlay G, Radermacher P, Hinds C, Pearse RM ( 2009 ) . Comparison of three methods of extravascular lung water volume measurement in patients after cardiac surgery . Crit Care vol. 13 , ( 4 )

Jhanji S, Stirling S, Patel NSA, Hinds CJ, Pearse RM ( 2009 ) . EFFECT OF INCREASING DOSES OF NOREPINEPHRINE ON TISSUE OXYGENATION AND MICROVASCULAR PERFUSION IN SEPTIC SHOCK . SHOCK . vol. 32 , 2 - 2 .

Jhanji S, Stirling S, Patel N, Hinds CJ, Pearse RM ( 2009 ) . Effect of increasing doses of noradrenaline on microvascular perfusion and tissue oxygenation in septic shock . Critical Care Medicine . Conference: The Intensive Care Society State of the Art Meeting ( London ) from: 15/12/2008 to: 16/12/2008 , vol. 37 , 1961 - 1966 .

Agha-Jaffar R, Hinds CJ ( 2009 ) . Growth hormone and multiple organ dysfunction syndrome . Journal of Organ Dysfunction vol. 5 , ( 1 ) 17 - 25 .

Maddison B, Giudici R, Calzia E, Wolff C, Hinds C, Radermacher P, Pearse RM ( 2008 ) . Extravascular lung water volume measurement by a novel lithium-thermal indicator dilution method: comparison of three techniques to post-mortem gravimetry . Intensive Care Med vol. 34 , ( 11 ) 2106 - 2111 .

Hinds CJ, Watson D ( 2008 ) . Intensive Care: A Concise Textbook . Saunders Ltd ( Edinburgh ),

Eisen DP, Dean MM, Boermeester MA, Fidler KJ, Gordon AC, Kronborg G, Kun JFJ, Lau YL et al. ( 2008 ) . Low serum mannose-binding lectin level increases the risk of death due to pneumococcal infection . CLIN INFECT DIS vol. 47 , ( 4 ) 510 - 516 .

Jhanji S, Thomas B, Ely A, Watson D, Hinds CJ, Pearse RM ( 2008 ) . Mortality and utilisation of critical care resources amongst high-risk surgical patients in a large NHS trust . Anaesthesia vol. 63 , ( 7 ) 695 - 700 .

Gordon A, Knight JC, Hinds CJ ( 2008 ) . Genes and sepsis: How tight is the fit? . CRIT CARE MED vol. 36 , ( 5 ) 1652 - 1654 .

Maddison B, Wolff C, Findlay G, Calzia E, Hinds C, Pearse R ( 2008 ) . Intrathoracic blood volume measurement: comparison of transpulmonary lithium indicator dilution with indocyanine green indicator dilution . Critical Care vol. 12 , ( Suppl 2 )

Jhanji S, Stirling S, Patel N, Hinds CJ, Pearse RM ( 2008 ) . Alterations in tissue oxygenation and microvascular flow during and after major abdominal surgery . Intensive Care Medicine . Conference: European Society of Intensive Care Medicine 21st Annual Congress ( Lisbon ) from: 21/09/2008 to: 24/09/2008 , vol. 34(Suppl. 1) , S150 - S150 .

Yasin M, Sivarajah A, Klaus R, Felsman K, Kieswich JE, Yaqoob MM, Hinds CJ, Bauer M et al. ( 2008 ) . Clondine Pre-treatment inhibits mitochondrial kapt channels and modulates the cardaic transcriptome to augment acute myocardial ischaemia reperfusion injury: A biphasic response . Intensive Care Medicine . Conference: European Society of Intensive Care Medicine 21st Annual Congress from: 21/09/2008 to: 24/09/2008 , vol. 34(Suppl. 1) , S160 - S160 .

Maddison B, Findlay G, Radermacher P, Hinds C, Pearse RM ( 2008 ) . Intrathoracic blood volume measurement: A comparison of transpulmonary lithium indicator dilution with indocyanine green indicator dilution . SHOCK . vol. 29 , 63 - 63 .

Ravic N, Tucker AT, Wareham DW, Johnston A, Hinds CJ ( 2007 ) . A study of novel oxides of nitrogen generating solution to prevent microbial colonization and ventilator associated pneumonia (VAP) . BRITISH JOURNAL OF CLINICAL PHARMACOLOGY . vol. 63 , 781 - 781 .

Hadley JS, Wang JE, Michaels LC, Dempsey CM, Foster SJ, Thiemermann C, Hinds CJ ( 2007 ) . Alterations in inflammatory capacity and TLR expression on monocytes and neutrophils after cardiopulmonary bypass . Shock vol. 27 , ( 5 ) 466 - 473 .

Maddison B, Best T, Wolff C, Jones P, Hinds C, Pearse R ( 2007 ) . Transpulmonary lithium indicator dilution: a new method of intrathoracic blood volume measurement . Critical Care vol. 11 , ( Suppl 2 )

Hinds CJ ( 2007 ) . A way forward for intensive care . Anaesthesia vol. 42 , ( 5 ) 551 - 551 .

Sury MRJ, Hinds CJ, Boustred M ( 2007 ) . Accidental discomexion following inactivation of Servoventilator alarm . Anaesthesia vol. 41 , ( 1 ) 91 - 91 .

HINDS CJ, ELLIS RH, SALOOJEE Y ( 2007 ) . Blood levels of nitrous oxide during bronchoscopy . Anaesthesia vol. 33 , ( 9 ) 784 - 787 .

HINDS CJ ( 2007 ) . Current management of patients after cardiopulmonary bypass . Anaesthesia vol. 37 , ( 2 ) 170 - 191 .

WATSON JD, FERGUSON C, HINDS CJ, SKINNER R, COAKLEY JH ( 2007 ) . Exertional heat stroke induced by amphetamine analogues . Anaesthesia vol. 48 , ( 12 ) 1057 - 1060 .

Ellis RH, Hinds CJ ( 2007 ) . Management of anaesthesia during tracheal resection . Anaesthesia vol. 32 , ( 4 ) 389 - 390 .

THOMAS DJB, HINDS CJ, REES GM ( 2007 ) . The management of insulin dependent diabetes during cardiopulmonary bypass and general surgery . Anaesthesia vol. 38 , ( 11 ) 1047 - 1052 .

Hinds CJ, Willatts SM ( 2007 ) . Training in intensive care . Anaesthesia vol. 39 , ( 3 ) 288 - 288 .

Garrard CS, Hinds CJ, Knight JC ( 2007 ) . Applications in critical care medicine . Genomics and Clinical Medicine , Editors: Kumar, D, Weatherell, D , Oxford University Press

Murch O, Collin M, Hinds CJ, Thiemermann C ( 2007 ) . Lipoproteins in inflammation and sepsis. I. Basic science . INTENS CARE MED vol. 33 , ( 1 ) 13 - 24 .

HINDS CJ, Thiermermann C, Foster SJ, Dempsey CM, Wang JE, Michaels LC, Hadley JS ( 2006 ) . Alterations in inflammatory capacity and TLR expression on monocytes and neutrophils following cardiopulmonary bypass . Shock

Pearse RM, Harrison DA, James P, Watson D, Hinds C, Rhodes A, Grounds RM, Bennett ED ( 2006 ) . Identification and characterisation of the high-risk surgical population in the United Kingdom . CRIT CARE vol. 10 , ( 3 ) Article R81 ,

Gordon AC, Waheed U, Hansen TK, Hitman GA, Garrard CS, Turner MW, Klein NJ, Brett SJ et al. ( 2006 ) . Mannose-binding lectin polymorphisms in severe sepsis: relationship to levels, incidence, and outcome . Shock vol. 25 , ( 1 ) 88 - 93 .

Pearse RM, Hinds CJ ( 2006 ) . Should we use central venous saturation to guide management in high-risk surgical patients? . Crit Care vol. 10 , ( 6 )

Teng Chung T, Hinds CJ ( 2006 ) . Treatment with GH and IGF-1 in critical illness . Crit Care Clin vol. 22 , ( 1 ) 29 - vi .

Hadley JS, Wang JE, Foster SJ, Thiemermann C, Hinds CJ ( 2005 ) . Peptidoglycan of Staphylococcus aureus upregulates monocyte expression of CD14, toll-like receptor 2 (TLR2), and TLR4 in human blood: Possible implications for priming of lipopolysaccharide signaling . INFECT IMMUN vol. 73 , ( 11 ) 7613 - 7619 .

Gordon AC, Oakervee HE, Kaya B, Thomas JM, Barnett MJ, Rohatiner AZS, Lister TA, Cavenagh JD et al. ( 2005 ) . Incidence and outcome of critical illness amongst hospitalised patients with haematological malignancy: a prospective observational study of ward and intensive care unit based care . Anaesthesia . vol. 60 , 340 - 347 .

Gordon AC, Oakervee HE, Kaya B, Thomas JM, Barnett MJ, AZS R, Lister TA, Cavenagh JD et al. ( 2005 ) . Incidence and outcome of critical illness amongst hospitalised patients with haematological malignancy: a prospective observational study of ward and intensive care unit based care . Anaesthesia vol. 60 , ( 4 ) 340 - 347 .

Hinds CJ, Watson JD ( 2005 ) . Intensive Care Medicine . Kumar and Clark clinical medicine , Editors: Kumar, PJ, Clark, ML , Saunders

Hadley JS, Wang JE, Michaels LC, Foster SJ, Thiemermann C, Hinds CJ ( 2005 ) . The effect of cardiopulmonary bypass (CPB) on monocyte receptor expression and ex vivo cytokine production . SHOCK . vol. 23 , 72 - 72 .

Botfield C, Hinds CJ ( 2004 ) . Growth Hormone and IGF-I as Anabolic Therapy . The Endocrine Response to Acute Illness , vol. 24 , Karger Publishers

Gordon AC, Lagan AL, Aganna E, Cheung L, Peters CJ, McDermott MF, Millo JL, Welsh KI et al. ( 2004 ) . TNF and TNFR polymorphisms in severe sepsis and septic shock: a prospective multicentre study . GENES IMMUN vol. 5 , ( 8 ) 631 - 640 .

Carlet J, Thijs LG, Antonelli M, Cassell J, Cox P, Hill N, Hinds C, Pimentel JM et al. ( 2004 ) . Challenges in end-of-life care in the ICU - Statement of the 5th International Consensus Conference in Critical Care: Brussels, Belgium, April 2003 . INTENS CARE MED vol. 30 , ( 5 ) 770 - 784 .

Wu AH, Hinds CJ, Thiemermann C ( 2004 ) . High-density lipoproteins in sepsis and septic shock: Metabolism, actions, and therapeutic applications . SHOCK vol. 21 , ( 3 ) 210 - 221 .

Hadley JS, Wang JE, Foster SJ, Thiemermann C, Hinds CJ ( 2004 ) . Cytokine responses to combined administration of lipopolysaccharide (LPS) and peptidoglycan (PepG) . SHOCK . vol. 21 , 50 - 50 .

HINDS CJ, Carle J, Thijs LG, Reinhart K, Sibbald WB, Taylor Thompson B, Pimentel J, Cox P et al. ( 2004 ) . International Consensus Conference on challenges in end of life care. Statement of the 5th International Consensus Conference in Critical Care . Crit care med vol. 32 , 1781 - 1784 .

Hadley JS, Wang JE, Foster SJ, Thiemermann C, Hinds CJ ( 2004 ) . Monocyte cell surface receptor upregulation in response to stimulation with lipopolysaccharide and peptidoglycan . SHOCK . vol. 21 , 21 - 21 .

O'Leary MJ, Koll M, Ferguson CN, Coakley JH, Hinds CJ, Preedy VR, Garlick PJ ( 2003 ) . Liver albumin synthesis in sepsis in the rat: influence of parenteral nutrition, glutamine and growth hormone . CLIN SCI vol. 105 , ( 6 ) 691 - 698 .

McDonald MC, Dhadly P, Cockerill GW, Cuzzocrea S, Mota-Filipe H, Hinds CJ, Miller NE, Thiemermann C ( 2003 ) . Reconstituted high-density lipoprotein attenuates organ injury and adhesion molecule expression in a rodent model of endotoxic shock . SHOCK vol. 20 , ( 6 ) 551 - 557 .

Fletcher SN, Kennedy DD, Ghosh IR, Misra VP, Kiff K, Coakley JH, Hinds CJ ( 2003 ) . Persistent neuromuscular and neurophysiologic abnormalities in long-term survivors of prolonged critical illness . CRIT CARE MED vol. 31 , ( 4 ) 1012 - 1016 .

Peters CJ, Aganna E, Nanjee MN, Cheung L, Gordon AC, Piper RD, Hitman G, Miller NE et al. ( 2003 ) . Relationship of paraoxonase 1 R/Q polymorphism to outcome from severe sepsis and septic shock . BRITISH JOURNAL OF ANAESTHESIA . vol. 90 , 539P - 539P .

Makings E, Hinds CJ ( 2003 ) . Monitoring . Classic Papers in Critical Care , Editors: Fink, M, Hayes, M, Soni, N , Blaydon Medial Publishing

McDonald MC, Dhadly P, Cockerill GW, Cuzzocrea S, Mota-Filipe H, Hinds CJ, Miller NE, Thiemermann C ( 2003 ) . Reconstituted high-density lipoprotein attenuates organ injury and adhesion molecule expression in a rodent model of endotoxic shock . Shock vol. 20 , 551 - 557 .

Hadley JS, Hinds CJ ( 2002 ) . Anabolic strategies in critical illness . CURR OPIN PHARMACOL vol. 2 , ( 6 ) 700 - 707 .

Oakervee HE, Gordon AC, Kaya B, Taussig DC, Lockley M, Barnett MJ, Rohatiner AZS, Lister TA et al. ( 2002 ) . Outcomes of critical illness in patients with haematological malignancy . BLOOD . vol. 100 , 875A - 876A .

Gordon AC, Oakervee HE, Kaya B, Barnett MJ, Rohatiner AZ, Lister TA, Watson JD, Cavenagh JD et al. ( 2002 ) . A prospective study of the incidence and outcome of critical illness in a haemato-oncology unit . INTENSIVE CARE MEDICINE . vol. 28 , S46 - S46 .

O'Leary MJ, Ferguson CN, Coakley JH, Hinds CJ, Preedy VR ( 2002 ) . Influence of starvation, surgery, and sepsis on cardiac protein synthesis in rats: Effects of parenteral nutrition, glutamine, and growth hormone . SHOCK vol. 18 , ( 3 ) 265 - 271 .

Gordon AC, Cheung L, Aganna E, Peters CJ, McDermott MF, Hitman GA, Piper RD, Hinds CJ ( 2002 ) . Lack of association between the-308 TNF promoter polymorphism & outcome from sepsis & septic shock . INTENSIVE CARE MEDICINE . vol. 28 , S99 - S99 .

Peters CJ, Nanjee MN, Gordon AC, Miller NE, Hinds CJ ( 2002 ) . Modification of High Density Lipoprotein in septic shock: relationship to outcome . INTENSIVE CARE MEDICINE . vol. 28 , S97 - S97 .

Gordon AC, Aganna E, Cheung L, Peters CJ, Piper RD, Mirakian RM, McDermott MF, Hitman GA et al. ( 2002 ) . Polymorphisms of the TNFRSF1B gene: Relationship to outcome from severe sepsis and septic shock . INTENSIVE CARE MEDICINE . vol. 28 , S99 - S99 .

Gordon AC, Aganna E, Cheung L, Peters CJ, Piper RD, Mirakian RM, McDermott MF, Hitman GA et al. ( 2002 ) . TNF RECEPTOR POLYMORPHISMS: RELATIONSHIP TO OUTCOME FROM SEVERE SEPSIS AND SEPTIC SHOCK . Shock vol. 18 , ( Supplement ) 8 - 9 .

Makings EA, Beddow ECL, Wilkes M, Patel M, Hadley J, Benjamin N, Hinds CJ ( 2002 ) . Decreased intragastric production of nitric oxide could predispose to ventilator-associated pneumonia . BRIT J ANAESTH vol. 89 , ( 2 ) 356P - 356P .

Peters CJ, Nanjee MN, Gordon AC, Miller NE, Hinds CJ ( 2002 ) . Proinflammatory modifications of lipoprotein structure and function in patients with septic shock: relationship to outcome . BRIT J ANAESTH vol. 89 , ( 2 ) 361P - 361P .

O'Leary MJ, Ferguson CN, Rennie M, Hinds CJ, Coakley JH, Preedy VR ( 2002 ) . Effect of growth hormone on muscle and liver protein synthesis in septic rats receiving glutamine-enriched parenteral nutrition . CRIT CARE MED vol. 30 , ( 5 ) 1099 - 1105 .

Smith PJ, Spurrell EL, Coakley J, Hinds CJ, Ross RJM, Krainer AR, Chew SL ( 2002 ) . An exonic splicing enhancer in human IGF-I pre-mRNA mediates recognition of alternative exon 5 by the serine-arginine protein splicing factor-2/alternative splicing factor . ENDOCRINOLOGY vol. 143 , ( 1 ) 146 - 154 .

Hinds CJ, Watson JD ( 2002 ) . Intensive Care Medicine . Kumar & Clark clinical medicine , Editors: Kumar, PJ, Kumar, P, Clark, ML , W B Saunders Co

Hinds CJ ( 2001 ) . Treatment of sepsis with activated protein C - Encouraging news for well selected patients . BRIT MED J vol. 323 , ( 7318 ) 881 - 882 .

O'Leary MJ, Koll M, Ferguson CN, Ahmed S, Mantle D, Hinds CJ, Coakley JH ( 2001 ) . Influence of nutrition, glutamine and growth hormone on skeletal muscle protease activity in septic rats . INTENS CARE MED vol. 27 , S205 - S205 .

O'Leary MJ, Ferguson CN, Rennie MJ, Hinds CJ, Coakley JH, Preedy VR ( 2001 ) . Sequential changes in in vivo muscle and liver protein synthesis and plasma and tissue glutamine levels in sepsis in the rat . CLIN SCI vol. 101 , ( 3 ) 295 - 304 .

O'Leary MJ, Koll M, Ferguson CN, Ahmed S, Mantle D, Hinds CJ, Coakley JH, Preedy VR ( 2001 ) . Skeletal muscle lysosomal protease activity in septic rats . INTENS CARE MED vol. 27 , S205 - S205 .

Johnson TS, O'Leary M, Justice SK, Maamra M, Zarkesh-Esfahani SH, Furlanetto R, Preedy VR, Hinds CJ et al. ( 2001 ) . Differential expression of suppressors of cytokine signalling genes in response to nutrition and growth hormone in the septic rat . J ENDOCRINOL vol. 169 , ( 2 ) 409 - 415 .

Wray GM, Foster SJ, Hinds CJ, Thiemermann C ( 2001 ) . A cell wall component from pathogenic and non-pathogenic gram-positive bacteria (peptidoglycan) synergises with endotoxin to cause the release of tumour necrosis factor-alpha, nitric oxide production, shock, and multiple organ injury/dysfunction in the rat . SHOCK vol. 15 , ( 2 ) 135 - 142 .

Ghosh IR, Kennedy DD, Fleter SN, Misra VP, Coakley JH, Hinds CJ ( 2001 ) . Identical persisting neurophysiological features of chronic denervation found in four cases of resolved critical illness motor syndrome . Clinical Intensive Care vol. 12 , 229 - 236 .

Kennedy DD, Fletcher SN, Ghosh IR, Hinds CJ, Coakley JH ( 2000 ) . Early detection of the covert onset and evolution of critical illness polyneuromyopathy . British Journal of Anaesthesia vol. 84 , ( 5 )

Dhadly P, McDonald MC, Cockerill G, Hinds CJ, Miller NE, Thiemermann C ( 2000 ) . Pre-treatment with high density lipoprotein (HDL) attenuates the renal and hepatic dysfunction caused by endotoxin in rats . British Journal of Anaesthesia vol. 84 , ( 5 ) 688p - 689p .

Kennedy DD, Fletcher N, Hinds C ( 2000 ) . Neuromuscular dysfunction in critical illness: what are we dealing with? . Current Opinion in Anaesthesiology vol. 13 , ( 2 )

O'Leary M, Koll M, Ferguson C, Hinds C, Preedy V, Coakley J, Garlick P ( 2000 ) . Parenteral nutrition (PN) depresses hepatic albumin synthesis in septic rats . Critical Care vol. 4 , ( Suppl 1 )

Botfield C, Hinds CJ ( 2000 ) . Growth hormone in catabolic illness . Current Opinion in Clinical Nutrition & Metabolic Care vol. 3 , ( 2 ) 139 - 144 .

Dhadly P, McDonald M, Cockerill G, Filipe HM, Hinds C, Miller N, Thiemermann C ( 2000 ) . High-density lipoprotein (HDL) reduces the renal injury and dysfunction in shock . 5TH WORLD CONGRESS ON TRAUMA, SHOCK, INFLAMMATION AND SEPSIS . 239 - 244 .

Takala J, Hinds CJ ( 2000 ) . Increased mortality associated with growth hormone treatment in critically ill adults - Reply . NEW ENGLAND JOURNAL OF MEDICINE vol. 342 , ( 2 ) 135 - 136 .

Malik SB, O'Leary M, Grimble GK, Hinds CJ, Coakley JH ( 2000 ) . The effect of glutamine supplementation on RNA turnover in critically-ill patients . PROCEEDINGS OF THE NUTRITION SOCIETY . vol. 59 , 138A - 138A .

Kennedy DD, Fletcher SN, Ghosh IR, Coakley JH, Monson JP, Hinds CJ ( 1999 ) . Reversible tetraplegia due to polyneuropathy in a diabetic patient with hyperosmolar non-ketotic coma . Intensive Care Medicine vol. 25 , ( 12 ) 1437 - 1439 .

Ferguson C, Coakley J, Koll M, Hinds CJ, O'Leary M, Preedy VR ( 1999 ) . EFFECT OF PARENTERAL FEED WITH OR WITHOUT GLUTAMINE AND GROWTH HORMONE ON SYNTHESIS OF CONTRACTILE AND CYTOPLASMIC PROTEIN IN THE GASTROCNEMIUS MUSCLE OF SEPTIC RATS . Shock . vol. 12 ,

Ferguson C, Coakley J, Koll M, Hinds CJ, O'Leary M, Preedy VR ( 1999 ) . FRACTIONAL PROTEIN SYNTHESIS RATES IN VIVO OF CONTRACTILE AND CYTOPLASMIC PROTEIN FRACTIONS OF SKELETAL MUSCLE IN THE SEPTIC RAT . Shock . vol. 12 , 54 - 55 .

Takala J, Ruokonen E, Webster NR, Nielsen MS, Zandstra DF, Vundelinckx G, Hinds CJ ( 1999 ) . Increased Mortality Associated with Growth Hormone Treatment in Critically Ill Adults . New England Journal of Medicine vol. 341 , ( 11 ) 785 - 792 .

Hinds CJ, Watson D ( 1999 ) . Circulatory support . The BMJ vol. 318 , ( 7200 )

Hinds CJ ( 1999 ) . Administration of growth hormone to catabolic patients . Growth Hormone & IGF Research . vol. 9 , 71 - 75 .

Griffiths RD, Hinds CJ, Little RA ( 1999 ) . Manipulating the metabolic response to injury . British Medical Bulletin vol. 55 , ( 1 ) 181 - 195 .

O’Leary MJ, Timmins AC, Appleby JN, Medbak S, Grossman AB, Nathan AW, Hinds CJ ( 1999 ) . Dissociation of pituitary-adrenal and catecholamine activation after induced cardiac arrest and defibrillation . British Journal of Anaesthesia vol. 82 , ( 2 ) 271 - 273 .

Fletcher SN, Kennedy DD, Ghosh IR, Misra PV, Coakley JH, Hinds CJ ( 1999 ) . Assessment of neuromuscular function in long-term survivors of prolonged critical illness . BRITISH JOURNAL OF ANAESTHESIA . vol. 82 , 798P - 799P .

Ghosh IR, Fletcher SN, Kennedy DD, Coakley JH, Hinds CJ ( 1999 ) . Follow-up EMG in critical illness neuromuscular disorders . BRITISH JOURNAL OF ANAESTHESIA . vol. 82 , 800P - 801P .

Hinds CJ, Fletcher SN ( 1999 ) . Ranitidine reduced clinically important gastrointestinal bleeding in patients who required mechanical ventilation . Gut vol. 44 , ( 1 )

Drake WM, Perry LA, Hinds CJ, Lowe DG, Reznek RH, Besser GM ( 1998 ) . Emergency and Prolonged Use of Intravenous Etomidate to Control Hypercortisolemia in a Patient with Cushing’s Syndrome and Peritonitis . The Journal of Clinical Endocrinology & Metabolism vol. 83 , ( 10 ) 3542 - 3544 .

Hinds CJ, Martin R, Quinton P ( 1998 ) . Intensive care for patients with medical complications of haematological malignancy: is it worth it? . Swiss Medical Weekly . vol. 128 , 1467 - 1473 .

Coakley JH, Nagendran K, Yarwood GD, Honavar M, Hinds CJ ( 1998 ) . Patterns of neurophysiological abnormality in prolonged critical illness . Intensive Care Medicine vol. 24 , ( 8 ) 801 - 807 .

Wray GM, Hinds CJ, Thiemermann C ( 1998 ) . EFFECTS OF INHIBITORS OF POLY(ADP-RIBOSE) SYNTHETASE ACTIVITY ON HYPOTENSION AND MULTIPLE ORGAN DYSFUNCTION CAUSED BY ENDOTOXIN . Shock vol. 10 , ( 1 ) 13 - 19 .

Wray GM, Millar CG, Hinds CJ, Thiemermann C ( 1998 ) . SELECTIVE INHIBITION OF THE ACTIVITY OF INDUCIBLE NITRIC OXIDE SYNTHASE PREVENTS THE CIRCULATORY FAILURE, BUT NOT THE ORGAN INJURY/DYSFUNCTION, CAUSED BY ENDOTOXIN . Shock vol. 9 , ( 5 ) 329 - 335 .

Wray GM, Hinds CJ, Thiemermann C ( 1998 ) . Cell wall fragments from Gram positive and Gram negative bacteria synergize to cause organ failure in the rat . British Journal of Anaesthesia . vol. 80 , 542 - 543 .

Wray G, Millar C, Leach M, Hinds C, Thiemermann C ( 1998 ) . The selective inhibitor of inducible nitric oxide synthase, 1400W, prevents the circulatory failure but not the organ injury caused by endotoxin in the rat . BRITISH JOURNAL OF PHARMACOLOGY . vol. 123 ,

Botfield C, Ross RJM, Hinds CJ ( 1997 ) . The role of IGFs in catabolism . Best Practice & Research Clinical Endocrinology & Metabolism vol. 11 , ( 4 ) 679 - 697 .

Ng TTC, Gibson FAM, Nye KE, Hughes PJ, Hinds CJ, Morrow WJW, Ferguson C ( 1997 ) . DESENSITIZATION OF THE INFLAMMATORY RESPONSE IN HUMANS . Shock vol. 8 , ( 3 ) 159 - 164 .

Yarwood GD, Ross RJM, Medbak S, Coakley J, Hinds CJ ( 1997 ) . Administration of human recombinant insulin-like growth factor-I in critically ill patients . Critical Care Medicine vol. 25 , ( 8 ) 1352 - 1361. .

Hayes MA, Timmins AC, Yau EHS, Palazzo M, Watson D, Hinds CJ ( 1997 ) . Oxygen transport patterns in patients with sepsis syndrome or septic shock . Critical Care Medicine vol. 25 , ( 6 ) 926 - 936. .

Gibson FAM, Hinds CJ ( 1997 ) . Growth hormone and insulin- like growth factors in critical illness . Intensive Care Medicine vol. 23 , ( 4 ) 369 - 378 .

Rodríguez-Arnao J, Yarwood G, Ferguson C, Miell J, Hinds CJ, Ross RJ ( 1996 ) . Reduction in circulating IGF-I and hepatic IGF-I mRNA levels after caecal ligation and puncture are associated with differential regulation of hepatic IGF-binding protein-1, -2 and -3 mRNA levels . Journal of Endocrinology vol. 151 , ( 2 ) 287 - 292 .

Timmins ACF, Cotterill AMM, Hughes SCPC, Holly JMPP, Ross RJMM, Blum WM, Hinds CJF ( 1996 ) . Critical illness is associated with low circulating concentrations of insulin-like growth factors-I and -II, alterations in insulin-like growth factor binding proteins, and induction of an insulin-like growth factor binding protein 3 protease . Critical Care Medicine vol. 24 , ( 9 ) 1460 - 1466. .

Hinds C, Watson D ( 1995 ) . Manipulating Hemodynamics and Oxygen Transport in Critically Ill Patients . New England Journal of Medicine vol. 333 , ( 16 ) 1074 - 1075 .

Hayes M, Timmins A, Yau E, Palazzo M, Hinds C, Watson D ( 1995 ) . Elevation of systemic oxygen delivery in the treatment of critically ill patients New Engl J Med 1994; 330/24: 1717–1722 . Resuscitation vol. 29 , ( 2 )

HAYES MA, TIMMINS AC, YAU EHS, PALAZZO M, HINDS CJ, WATSON D ( 1995 ) . Elevation of Systemic Oxygen in the Treatment of Critically Ill Patients . Survey of Anesthesiology vol. 39 , ( 1 )

Pick B, Molloy A, Hinds C, Pearce S, Salmon P ( 1994 ) . Post-operative fatigue following coronary artery bypass surgery: Relationship to emotional state and to the catecholamine response to surgery . Journal of Psychosomatic Research vol. 38 , ( 6 ) 599 - 607 .

Hayes MA, Timmins AC, Yau E, Palazzo M, Hinds CJ, Watson D ( 1994 ) . Elevation of Systemic Oxygen Delivery in the Treatment of Critically Ill Patients . New England Journal of Medicine vol. 330 , ( 24 ) 1717 - 1722 .

TlMMINS AC, GILES M, NATHAN AW, HINDS CJ ( 1994 ) . Clinical validation of a radionuclide detector to measure ejection fraction in critically ill patients . British Journal of Anaesthesia vol. 72 , ( 5 ) 523 - 528 .

Hinds CJ, Yarwood GD, Coakley JH ( 1994 ) . Acquired Neuromuscular Abnormalities in Intensive Care Patients . Yearbook of Intensive Care and Emergency Medicine 1994 , Springer Nature

HAYES MA, PALAZZO M, HINDS CJ, WATSON D ( 1994 ) . ELEVATION OF SYSTEMIC OXYGEN DELIVERY IN THE TREATMENT OF CRITICALLY ILL PATIENTS - REPLY . NEW ENGLAND JOURNAL OF MEDICINE vol. 331 , ( 17 ) 1161 - 1162 .

Hinds CJ, Nagendran K, Honauar M, Coakley JH ( 1993 ) . Muscle Relaxants in Intensive Care Patients . Critical Care Medicine vol. 21 , ( 9 ) 1403 - 1404 .

Hinds CJ, Watson JD, Hayes M, Palazzo M ( 1993 ) . High dose inotropic support in septic shock . The BMJ vol. 307 , ( 6901 )

Palazzo M, Soni N, Hinds C ( 1993 ) . Physiological scoring systems and audit . The Lancet vol. 342 , ( 8866 )

Rothwell PM, Chang RS, Bihari D, Hasibeder W, Haisjackl M, Germann R, Vergeiner R, Seyr M et al. ( 1993 ) . Physiological scoring systems and audit . The Lancet vol. 342 , ( 8866 ) 306 - 308 .

Coakley JH, Nagendran K, Honavar M, Hinds CJ ( 1993 ) . Preliminary observations on the neuromuscular abnormalities in patients with organ failure and sepsis . Intensive Care Medicine vol. 19 , ( 6 ) 323 - 328 .

Donaldson MD, Vesey CJ, Bouloux PM, Watson JD, Besser GM, Hinds CJ ( 1993 ) . Plasma catecholamine levels in porcine Escherichia coli septicaemia and following treatment with buprenorphine or naloxone . Journal of inflammation vol. 39 , ( 3 ) 169 - 177 .

Hayes MA, Yau EHS, Timmins AC, Hinds CJ, Watson D ( 1993 ) . Response of Critically III Patients to Treatment Aimed at Achieving Supranormal Oxygen Delivery and Consumption Relationship to Outcome . CHEST Journal vol. 103 , ( 3 ) 886 - 895 .

CATNACH SM, HINDS CJ, FAIRCLOUGH PD ( 1993 ) . ENTERAL NUTRITION DOES NOT PROTECT AGAINST BILIARY SLUDGE IN CRITICALLY ILL PATIENTS . GASTROENTEROLOGY . vol. 104 , A352 - A352 .

Cwyfan Hughes SC, Cotterill AM, Molloy AR, Cassell TB, Braude N, Hinds CJ, Wass JA, Holly JM ( 1992 ) . The induction of specific proteases for insulin-like growth factor-binding proteins following major heart surgery . Journal of Endocrinology vol. 135 , ( 1 ) 135 - 145 .

Gore SM, Armitage WJ, Briggs JD, Crombie A, Easty DL, Hinds CJ, Jamieson NV, Johnston P et al. ( 1992 ) . Consensus on general medical contraindications to organ donation? . The BMJ vol. 305 , ( 6850 )

Hayes MA, Yau EHS, Hinds CJ, Watson JD ( 1992 ) . Symmetrical peripheral gangrene: association with noradrenaline administration . Intensive Care Medicine vol. 18 , ( 7 ) 433 - 436 .

Coakley JH, Nagendran K, Ormerod IEC, Ferguson CN, Hinds CJ ( 1992 ) . Prolonged Neurogenic Weakness in Patients Requiring Mechanical Ventilation for Acute Airflow Limitation . CHEST Journal vol. 101 , ( 5 ) 1413 - 1416 .

Hinds CJ ( 1992 ) . Monoclonal antibodies in sepsis: Author's reply . The BMJ vol. 304 , ( 6833 )

Hinds CJ ( 1992 ) . Monoclonal antibodies in sepsis and septic shock . The BMJ vol. 304 , ( 6820 )

Timmins AC, Hayes M, Yau E, Watson JD, Hinds CJ ( 1992 ) . The relationship between cardiac reserve and survival in critically ill patients receiving treatment aimed at achieving supranormal oxygen delivery and consumption . Postgraduate Medical Journal . vol. 68 Suppl 2 , s34 - s40 .

Donaldson MD, Vesey CJ, Wilks M, Watson JD, Hinds CJ ( 1991 ) . Lack of effect of ACTH in porcine Escherichia coli septic shock . Journal of inflammation vol. 35 , ( 3 ) 152 - 158 .

Yau E, Rohatiner A, Lister T, Hinds C ( 1991 ) . Long term prognosis and quality of life following intensive care for life-threatening complications of haematological malignancy . British Journal of Cancer vol. 64 , ( 5 ) 938 - 942 .

Timmins AC, Hinds CJ ( 1991 ) . Availability of cadaver organs for transplantation . The BMJ vol. 303 , ( 6802 )

Amos RJ, Deane M, Ferguson C, Jeffries G, Hinds CJ, Amess JA ( 1990 ) . Observations on the haemopoietic response to critical illness . Journal of Clinical Pathology vol. 43 , ( 10 )

Gore SM, Holland AJ, Hinds CJ ( 1990 ) . Organs for transplantation . The BMJ vol. 300 , ( 6722 )

HINDS CJ, AMESS JAL, JEFFERIES G, FERGUSON C, AMOS RJ ( 1990 ) . ABNORMALITIES OF BONE-MARROW MORPHOLOGY AND FUNCTION IN CRITICALLY ILL PATIENTS . INTENSIVE AND CRITICAL CARE MEDICINE . vol. 885 , 1067 - 1067 .

Hinds CJ, Yau EHS ( 1990 ) . Intensive Care for Complications of Malignant Disease: Presentation and Outcome . Update 1990 , vol. 10 , Springer Nature

Gore SM, Rutherford AJ, Hinds CJ ( 1989 ) . Organ donation from intensive care units in England . The BMJ vol. 299 , ( 6712 )

Gore SM, Hinds CJ, Rutherford AJ ( 1989 ) . Organ donation from intensive care units in England . The BMJ vol. 299 , ( 6709 )

Van Besouw JP, Hinds CJ ( 1989 ) . Fat embolism syndrome . British Journal of Hospital Medicine vol. 42 , ( 4 ) 304 - 311 .

McLoughlin L, Evans SF, Watson JD, Hinds CJ, Rees LH ( 1988 ) . Characterization of circulating pro-opiomelanocortin-related peptides in human septic shock . Journal of Endocrinology vol. 119 , ( 1 ) 159 - 165 .

Watson JD, Varley JG, Bouloux PM, Tomlin SJ, Rees LH, Besser GM, Hinds CJ ( 1988 ) . Adrenal vein and arterial levels of catecholamines and immunoreactive metenkephalin in canine endotoxin shock and their response to naloxone . Research in Experimental Medicine vol. 188 , ( 5 ) 319 - 328 .

Watson JD, Varley JG, Tomlin SJ, Medbak S, Perry L, Bouloux PM, Rees LH, Besser GM et al. ( 1988 ) . Neuroendocrine and cardiovascular responses to high-dose corticosteroid therapy in canine endotoxin shock . Research in Experimental Medicine vol. 188 , ( 5 ) 329 - 339 .

Donaldson MD, Vesey CJ, Wilks M, Hinds CJ ( 1988 ) . Beneficial effects of buprenorphine (a partial opiate agonist) in porcine Escherichia coli septicaemia: a comparison with naloxone . Journal of inflammation vol. 25 , ( 3 ) 209 - 221 .

Lloyd-Thomas AR, Wright I, Lister TA, Hinds CJ ( 1988 ) . Prognosis of patients receiving intensive care for lifethreatening medical complications of haematological malignancy . The BMJ vol. 296 , ( 6628 )

Watson JD, Sury MR, Corder R, Carson R, Bouloux PM, Lowry PJ, Besser GM, Hinds CJ ( 1988 ) . Plasma levels of neuropeptide tyrosine Y (NPY) are increased in human sepsis but are unchanged during canine endotoxin shock despite raised catecholamine concentrations . Journal of Endocrinology vol. 116 , ( 3 ) 421 - 426 .

Procaccio F, Bingham RM, Hinds CJ, Prior PF ( 1988 ) . Continuous EEG and ICP monitoring as a guide to the administration of althesin sedation in severe head injury . Intensive Care Medicine vol. 14 , ( 2 ) 148 - 155 .

DONALDSON M, VESEY C, WILKS M, HINDS C ( 1988 ) . BENEFICIAL-EFFECTS OF BUPRENORPHINE (A PARTIAL OPIATE AGONIST) IN PORCINE ESCHERICHIA-COLI SEPTICEMIA - A COMPARISON WITH NALOXONE . CIRCULATORY SHOCK vol. 24 , ( 3 ) 194 - 195 .

Amos RJ, Kirk B, Amess JAL, Jones AL, Hinds CJ ( 1987 ) . Bone Marrow Hypoplasia During Intensive Care: Bone Marrow Culture Studies Implicating Ranitidine in the Suppression of Haemopoiesis . Human & Experimental Toxicology vol. 6 , ( 6 ) 503 - 506 .

Grebenik CR, Hinds CJ ( 1987 ) . Management of the multiple organ donor . British Journal of Hospital Medicine vol. 38 , ( 1 ) 62 - 65 .

BINGHAM RM, HINDS CJ ( 1987 ) . INFLUENCE OF BOLUS DOSES OF PHENOPERIDINE ON INTRACRANIAL PRESSURE AND SYSTEMIC ARTERIAL PRESSURE IN TRAUMATIC COMA . British Journal of Anaesthesia vol. 59 , ( 5 ) 592 - 595 .

Watson JD, Varley JG, Tomlin SJ, Medbak S, Rees LH, Hinds CJ ( 1986 ) . Biochemical characterization of circulating Met-enkephalins in canine endotoxin shock . Journal of Endocrinology vol. 111 , ( 2 ) 329 - 334 .

Lloyd-Thomas AR, Dhaliwal HS, Lister TA, Hinds CJ ( 1986 ) . Intensive therapy for life-threatening medical complications of haematological malignancy . Intensive Care Medicine vol. 12 , ( 4 ) 317 - 324 .

WATSON JD, CORDER R, CARSON R, BOULOUX PM, LOWRY PJ, BESSER GM, HINDS CJ ( 1986 ) . LACK OF RELATIONSHIP BETWEEN PLASMA-LEVELS OF CATECHOLAMINES AND NEUROPEPTIDE-Y IMMUNOREACTIVITY DURING ENDOTOXIN-SHOCK . CIRCULATORY SHOCK . vol. 19 , 105 - 105 .

Amos RJ, Amess JA, Hinds CJ, Mollin DL ( 1985 ) . Investigations into the effect of nitrous oxide anaesthesia on folate metabolism in patients receiving intensive care . Journal of Chemotherapy vol. 4 , ( 5 ) 393 - 399 .

Hinds CJ ( 1985 ) . Opiate antagonists in shock . British Journal of Hospital Medicine vol. 34 , ( 4 ) 233 - 234 .

Hinds CJ ( 1985 ) . Prevention and treatment of brain ischaemia . The BMJ vol. 291 , ( 6498 )

BINGHAM RM, PROCACCIO F, PRIOR PF, HINDS CJ ( 1985 ) . CEREBRAL ELECTRICAL ACTIVITY INFLUENCES THE EFFECTS OF ETOMIDATE CEREBRAL PERFUSION PRESSURE IN TRAUMATIC COMA . British Journal of Anaesthesia vol. 57 , ( 9 ) 843 - 848 .

McCulloch W, Price P, Hinds CJ, Wass JAH ( 1985 ) . Effects of low dose oral triiodothyronine in myxoedema coma . Intensive Care Medicine vol. 11 , ( 5 ) 259 - 262 .

Hinds CJ, Evans SF, Varley JG, Tomlin S, Rees LH ( 1985 ) . Neuroendocrine and cardiovascular changes in septic shock and after cardiac surgery: effect of high-dose corticosteroid therapy . Journal of inflammation vol. 15 , ( 1 ) 61 - 72 .

Watson JD, Bouloux PM, Hinds CJ ( 1984 ) . ABC of poisoning: opioids . The BMJ vol. 289 , ( 6457 )

Glynn C ( 1984 ) . Etomidate and adrenocortical function . Intensive Care Medicine vol. 10 , ( 5 ) 268 - 269 .

THOMAS DJB, HINDS CJ, REES GM ( 1984 ) . The Management of Insulin Dependent Diabetes During Cardiopulmonary Bypass and General Surgery . Survey of Anesthesiology vol. 28 , ( 4 )

Evans SF, Medbak S, Hinds CJ, Tomlin SJ, Varley JG, Rees LH ( 1984 ) . Plasma levels and biochemical characterisation of circulating met-enkephalin in canine endotoxin shock . Life Sciences vol. 34 , ( 15 ) 1481 - 1486 .

WATSON JD, VARLEY JG, HINDS CJ, BOULOUX PM, TOMLIN S, REES LH ( 1984 ) . ADRENAL VEIN AND SYSTEMIC LEVELS OF CATECHOLAMINES AND METENKEPHALIN-LIKE IMMUNOREACTIVITY IN CANINE ENDOTOXIN-SHOCK - EFFECTS OF NALOXONE ADMINISTRATION . CIRCULATORY SHOCK . vol. 13 , 47 - 48 .

Hinds CJ, Roberts MJ, Ingram D, Dickinson CJ ( 1984 ) . Computer simulation to predict patient responses to alterations in the ventilation regime . Intensive Care Medicine vol. 10 , ( 1 ) 13 - 22 .

Roberts MJ, Boustred ML, Hinds CJ ( 1983 ) . A multipatient mass spectrometer based system for the measurement of metabolic gas exchange in artificially ventilated intensive care patients . Intensive Care Medicine vol. 9 , ( 6 ) 339 - 343 .

Prior JGL, Hinds CJ, Williams J, Prior PF ( 1983 ) . The use of etomidate in the management of severe head injury . Intensive Care Medicine vol. 9 , ( 6 ) 313 - 320 .

EVANS SF, VARLEY JG, HINDS CJ ( 1983 ) . EFFECTS OF NALOXONE IN CANINE ENDOTOXIN-SHOCK . CIRCULATORY SHOCK . vol. 10 , 234 - 234 .

Amos RJ, Hinds CJ, Amess JAL, Mollin DL ( 1982 ) . INCIDENCE AND PATHOGENESIS OF ACUTE MEGALOBLASTIC BONE-MARROW CHANGE IN PATIENTS RECEIVING INTENSIVE CARE . The Lancet vol. 320 , ( 8303 ) 835 - 839 .

Hinds CJ, Ingram D, Dickinson CJ ( 1982 ) . Self-instruction and assessment in techniques of intensive care using a computer model of the respiratory system . Intensive Care Medicine vol. 8 , ( 3 ) 115 - 123 .

AMESS JA, HINDS CJ, MOLLIN DL ( 1982 ) . A STUDY OF MEGALOBLASTIC CHANGE DEVELOPING IN PATIENTS RECEIVING INTENSIVE-CARE . BRITISH JOURNAL OF HAEMATOLOGY . vol. 51 , 329 - 329 .

KRAPEZ JR, SALOOJEE Y, HINDS CJ, HACKETT GH, COLE PV ( 1980 ) . BLOOD CONCENTRATIONS OF NITROUS OXIDE IN THEATRE PERSONNEL . British Journal of Anaesthesia vol. 52 , ( 11 ) 1143 - 1148 .

Hinds CJ, Ingram D, Adams L, Cole PV, Dickinson CJ, Kay J, Krapez JR, Williams J ( 1980 ) . An Evaluation of the Clinical Potential of a Comprehensive Model of Human Respiration in Artificially Ventilated Patients . Clinical Science vol. 58 , ( 1 ) 83 - 91 .

COLE AGH, HINDS CJ, COLE PV ( 1980 ) . FENTANYL BY INFUSION - METHOD OF TOTAL DOSE REDUCTION . BRITISH JOURNAL OF ANAESTHESIA . vol. 52 , P229 - P229 .

HINDS CJ, INGRAM D, DICKINSON CJ ( 1980 ) . SELF INSTRUCTION AND ASSESSMENT IN TECHNIQUES OF INTENSIVE-CARE USING A COMPUTER-MODEL OF THE RESPIRATORY SYSTEM . INTENSIVE CARE MEDICINE . vol. 6 , 82 - 82 .

Ingram D, Hinds CJ, Dickinson CJ ( 1979 ) . Clinical Applications of a Holistic Model . Clinical Science vol. 56 , ( 3 ) 29p - 29p .