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Publications: Prof Kairbaan Hodivala-Dilke

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Guelfi S, Hodivala-Dilke K, Bergers G ( 2024 ) . Targeting the tumour vasculature: from vessel destruction to promotion . Nature Reviews Cancer vol. 24 , ( 10 ) 655 - 675 .
Njegić A, Laid L, Zi M, Maniati E, Wang J, Chelu A, Wisniewski L, Hunter J et al. ( 2024 ) . Treatment with αvβ3-integrin-specific 29P attenuates pressure-overload induced cardiac remodelling after transverse aortic constriction in mice . Journal of Molecular and Cellular Cardiology Plus vol. 8 ,
Reynolds LE, Maallin S, Haston S, Martinez‐Barbera JP, Hodivala‐Dilke KM, Pedrosa A ( 2023 ) . Effects of senescence on the tumour microenvironment and response to therapy . The FEBS Journal vol. 291 , ( 11 ) 2306 - 2319 .
Lechertier T, Reynolds LE, Kim H, Pedrosa AR, Gómez-Escudero J, Muñoz-Félix JM, Batista S, Dukinfield M et al. ( 2023 ) . Author Correction: Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth . Nature Communications vol. 14 , ( 1 )
Hübers C, Pari AAA, Grieshober D, Petkov M, Schmidt A, Messmer T, Heyer CM, Schölch S et al. ( 2022 ) . Primary tumor–derived systemic nANGPTL4 inhibits metastasis . Journal of Experimental Medicine vol. 220 , ( 1 )
D'Amico G, Fernandez I, Gómez-Escudero J, Kim H, Maniati E, Azman MS, Mardakheh FK, Serrels B et al. ( 2022 ) . ERG activity is regulated by endothelial FAK coupling with TRIM25/USP9x in vascular patterning . Development vol. 149 , ( 13 )
Roy-Luzarraga M, Reynolds LE, de Lux�n-Delgado B, Maiques O, Wisniewski L, Newport E, Rajeeve V, Drake RJG et al. ( 2022 ) . Suppression of endothelial cell FAK expression reduces pancreatic ductal adenocarcinoma metastasis after gemcitabine treatmentEC FAK regulates gemcitabine treated liver metastasis . Cancer Research vol. 82 , ( 10 ) 1909 - 1925 .
Murray ER, Menezes S, Henry JC, Williams JL, Alba-Castellón L, Baskaran P, Quétier I, Desai A et al. ( 2022 ) . Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion . Cell Reports vol. 38 , ( 4 )
Newport E, Pedrosa AR, Lees D, Dukinfield M, Carter E, Gomez‐Escudero J, Casado P, Rajeeve V et al. ( 2021 ) . Elucidating the role of the kinase activity of endothelial cell focal adhesion kinase in angiocrine signalling and tumour growth . The Journal of Pathology vol. 256 , ( 2 ) 235 - 247 .
Newport EL, Pedrosa AR, Njegic A, Hodivala-Dilke KM, Muñoz-Félix JM ( 2021 ) . Improved Immunotherapy Efficacy by Vascular Modulation . Cancers vol. 13 , ( 20 )
Delvecchio FR, Fincham REA, Spear S, Clear A, Roy-Luzarraga M, Balkwill FR, Gribben JG, Bombardieri M et al. ( 2021 ) . Pancreatic Cancer Chemotherapy Is Potentiated by Induction of Tertiary Lymphoid Structures in Mice . Cellular and Molecular Gastroenterology and Hepatology vol. 12 , ( 5 ) 1543 - 1565 .
Lees DM, Reynolds LE, Pedrosa AR, Roy-Luzarraga M, Hodivala-Dilke KM ( 2021 ) . Correction to: Phosphorylation of pericyte FAK‑Y861 affects tumour cell apoptosis and tumour blood vessel regression . Angiogenesis vol. 24 , ( 3 ) 483 - 487 .
Lees DM, Reynolds LE, Pedrosa AR, Roy-Luzarraga M, Hodivala-Dilke KM ( 2021 ) . Phosphorylation of pericyte FAK-Y861 affects tumour cell apoptosis and tumour blood vessel regression . Angiogenesis vol. 24 , ( 3 ) 471 - 482 .
Roy-Luzarraga M, Reynolds L, Hodivala-Dilke K ( 2020 ) . Regulation of tumour progression and metastasis by Endothelial-FAK upon chemotherapy treatment . Pancreatology vol. 20 , ( 8 )
Roy-Luzarraga M, Abdel-Fatah T, Reynolds LE, Clear A, Taylor JG, Gribben JG, Chan S, Jones L et al. ( 2020 ) . Association of Low Tumor Endothelial Cell pY397–Focal Adhesion Kinase Expression With Survival in Patients With Neoadjuvant-Treated Locally Advanced Breast Cancer . JAMA Network Open vol. 3 , ( 10 )
Abdul Pari AA, Singhal M, Hübers C, Mogler C, Schieb B, Gampp A, Gengenbacher N, Reynolds LE et al. ( 2020 ) . Tumor Cell–Derived Angiopoietin-2 Promotes Metastasis in Melanoma . Cancer Research vol. 80 , ( 12 ) 2586 - 2598 .
Lechertier T, Reynolds LE, Kim H, Pedrosa AR, Gómez-Escudero J, Muñoz-Félix JM, Batista S, Dukinfield M et al. ( 2020 ) . Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth . Nature Communications vol. 11 , ( 1 )
Gomez-Escudero J, Maniati E, Whiting F, Wang J, Graham T, Hodivala-Dilke K ( 2020 ) . Abstract A31: Tumor stroma in the development of acquired cancer therapy resistance . Cancer Research . vol. 80 , a31 - a31 .
Wong P-P, Muñoz-Félix JM, Hijazi M, Kim H, Robinson SD, De Luxán-Delgado B, Rodríguez-Hernández I, Maiques O et al. ( 2020 ) . Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk with Tumor Cells . Cell vol. 181 , ( 6 ) 1346 - 1363.e21 .
Demircioglu F, Wang J, Candido J, Costa ASH, Casado P, de Luxan Delgado B, Reynolds LE, Gomez-Escudero J et al. ( 2020 ) . Cancer associated fibroblast FAK regulates malignant cell metabolism . Nature Communications vol. 11 , ( 1 ) 1290 - 1290 .
Wilcz‐Villega E, Carter E, Ironside A, Xu R, Mataloni I, Holdsworth J, Jones W, Moreno Béjar R et al. ( 2020 ) . Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway . EMBO Molecular Medicine vol. 12 , ( 2 )
D'Amico G, Muñoz‐Félix JM, Pedrosa AR, Hodivala‐Dilke KM ( 2019 ) . “Splitting the matrix”: intussusceptive angiogenesis meets MT1‐MMP . EMBO Molecular Medicine vol. 12 , ( 2 )
Dukinfield M, Maniati E, Reynolds LE, Aubdool A, Baliga RS, D'Amico G, Maiques O, Wang J et al. ( 2019 ) . Repurposing an anti‐cancer agent for the treatment of hypertrophic heart disease . The Journal of Pathology vol. 249 , ( 4 ) 523 - 535 .
Li J, Fukase Y, Shang Y, Zou W, Muñoz-Félix JM, Buitrago L, van Agthoven J, Zhang Y et al. ( 2019 ) . Novel Pure αVβ3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations . ACS Pharmacology & Translational Science vol. 2 , ( 6 ) 387 - 401 .
Pedrosa A-R, BODRUG N, Gomez-Escudero J, Carter EP, Reynolds LE, Georgiou PN, Fernandez I, Lees DM et al. ( 2019 ) . Tumour angiogenesis is differentially regulated by endothelial cell Focal Adhesion Kinase tyrosine-397 and -861 phosphorylation . Cancer Research
Li Z, Solomonidis EG, Meloni M, Taylor RS, Duffin R, Dobie R, Magalhaes MS, Henderson BEP et al. ( 2019 ) . Single-cell transcriptome analyses reveal novel targets modulating cardiac neovascularization by resident endothelial cells following myocardial infarction . European Heart Journal vol. 40 , ( 30 ) 2507 - 2520 .
Moyes AJ, Chu SM, Aubdool AA, Dukinfield MS, Margulies KB, Bedi KC, Hodivala-Dilke K, Baliga RS et al. ( 2019 ) . C-type natriuretic peptide co-ordinates cardiac structure and function . European Heart Journal vol. 41 , ( 9 ) 1006 - 1020 .
Foxler DE, Bridge KS, Foster JG, Grevitt P, Curry S, Shah KM, Davidson KM, Nagano A et al. ( 2018 ) . A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia . EMBO Mol Med
Hynes RO, Hodivala-Dilke KM ( 2017 ) . Insights and Questions Arising from Studies of a Mouse Model of Glanzmann Thrombasthenia . Thrombosis and Haemostasis vol. 82 , ( 02 ) 481 - 485 .
Tsakiris DA, Scudder L, Hodivala-Dilke K, Hynes RO, Coller BS ( 2017 ) . Hemostasis in the Mouse (Mus musculus): A Review . Thrombosis and Haemostasis vol. 81 , ( 02 ) 177 - 188 .
Weinmüller M, Rechenmacher F, Marelli UK, Reichart F, Kapp TG, Räder AFB, Di Leva FS, Marinelli L et al. ( 2017 ) . Overcoming the Lack of Oral Availability of Cyclic Hexapeptides: Design of a Selective and Orally Available Ligand for the Integrin αvβ3 . Angewandte Chemie International Edition vol. 56 , ( 51 ) 16405 - 16409 .
Alexopoulou AN, Lees DM, Bodrug N, Lechertier T, Fernandez I, D'Amico G, Dukinfield M, Batista S et al. ( 2017 ) . Focal Adhesion Kinase (FAK) tyrosine 397E mutation restores the vascular leakage defect in endothelium‐specific FAK‐kinase dead mice . The Journal of Pathology vol. 242 , ( 3 ) 358 - 370 .
Ross JA, Webster RG, Lechertier T, Reynolds LE, Turmaine M, Bencze M, Jamshidi Y, Cetin H et al. ( 2017 ) . Multiple roles of integrin-α3 at the neuromuscular junction . Journal of Cell Science vol. 130 , ( 10 ) 1772 - 1784 .
Reynolds LE, D'Amico G, Lechertier T, Papachristodoulou A, Muñoz-Félix JM, De Arcangelis A, Baker M, Serrels B et al. ( 2017 ) . Dual role of pericyte α6β1-integrin in tumour blood vessels . Journal of Cell Science vol. 130 , ( 9 ) 1583 - 1595 .
( 2017 ) . Correction: A Promyelocytic Leukemia Protein-Thrombospondin-2 Axis and the Risk of Relapse in Neuroblastoma . Clinical Cancer Research vol. 23 , ( 3 ) 870 - 870 .
Rudran B, Desai A, Luzarraga M, Hodivala-Dilke K, Foster J, Sosabowski J, Marshall J ( 2017 ) . Development of non-invasive imaging of integrin alpha-v-beta-6 (alpha v beta 6)-positive lung cancers in advance of testing alpha v beta 6-targeted therapies . Lung Cancer . Conference: British Thoracic Oncology Group Conference 2017 ( Dublin, Ireland ) from: 25/01/2017 to: 27/01/2017 , vol. 103 , S4 - S4 .
Wong P-P, Bodrug N, Hodivala-Dilke KM ( 2016 ) . Exploring Novel Methods for Modulating Tumor Blood Vessels in Cancer Treatment . Current Biology vol. 26 , ( 21 ) r1161 - r1166 .
Demircioglu F, Hodivala-Dilke K ( 2016 ) . αvβ3 Integrin and tumour blood vessels—learning from the past to shape the future . Current Opinion in Cell Biology vol. 42 , 121 - 127 .
Roy-Luzarraga M, Hodivala-Dilke K ( 2016 ) . Molecular Pathways: Endothelial Cell FAK--A Target for Cancer Treatment . Clinical Cancer Research vol. 22 , ( 15 ) 3718 - 3724 .
Di Maggio F, Arumugam P, Delvecchio FR, Batista S, Lechertier T, Hodivala-Dilke K, Kocher HM ( 2016 ) . Pancreatic stellate cells regulate blood vessel density in the stroma of pancreatic ductal adenocarcinoma . Pancreatology
Dvorkina M, Nieddu V, Chakelam S, Pezzolo A, Cantilena S, Leite AP, Chayka O, Regad T et al. ( 2016 ) . A promyelocytic leukemia protein-thrombospondin 2 axis and the risk of relapse in neuroblastoma . Clinical Cancer Research
Martins VL, Caley MP, Moore K, Szentpetery Z, Marsh ST, Murrell DF, Kim MH, Avari M et al. ( 2015 ) . Suppression of TGFβ and Angiogenesis by Type VII Collagen in Cutaneous SCC . J Natl Cancer Inst vol. 108 , ( 1 )
Ross J, Webster R, Lechertier T, Reynolds L, Muntoni F, Beeson D, Hodivala-Dilke K, Conti F ( 2015 ) . G.O.9 Integrins are required for synaptic transmission and development of the neuromuscular junction . Neuromuscular Disorders . vol. 25 ,
Gopinathan G, Milagre C, Pearce OMT, Reynolds LE, Hodivala-Dilke K, Leinster DA, Zhong H, Hollingsworth RE et al. ( 2015 ) . Interleukin-6 Stimulates Defective Angiogenesis . Cancer Research vol. 75 , ( 15 ) 3098 - 3107 .
Gopinathan G, Milagre C, Pearce OMT, Reynolds L, Hodivala-Dilke K, Leinster A, Zhong H, Hollingsworth RE et al. ( 2015 ) . Abstract 4162: Interleukin–6 stimulates defective angiogenesis . Cancer Research vol. 75 , ( 15_Supplement ) 4162 - 4162 .
Wong P-P, Demircioglu F, Ghazaly E, Alrawashdeh W, Stratford MRL, Scudamore CL, Cereser B, Crnogorac-Jurcevic T et al. ( 2015 ) . Dual-Action Combination Therapy Enhances Angiogenesis while Reducing Tumor Growth and Spread . Cancer Cell vol. 27 , ( 1 ) 123 - 137 .
Wong P-P, Demircioglu F, Ghazaly E, Alrawashdeh W, Stratford M, Scudamore C, Cereser B, Crnogorac-Jurcevic T et al. ( 2015 ) . NOVEL DUAL-ACTION COMBINATION THERAPY ENHANCES ANGIOGENESIS WHILST REDUCING TUMOR GROWTH AND SPREAD . JOURNAL OF VASCULAR RESEARCH . vol. 52 , 6 - 6 .
Birdsey GM, Shah AV, Dufton N, Reynolds LE, Almagro LO, Yang Y, Aspalter IM, Mason JC et al. ( 2015 ) . REGULATION OF VASCULAR DEVELOPMENT AND ANGIOGENESIS BY THE TRANSCRIPTION FACTOR ERG . JOURNAL OF VASCULAR RESEARCH . vol. 52 , 17 - 18 .
Birdsey GM, Shah AV, Dufton N, Reynolds LE, Almagro LO, Yang Y, Aspalter IM, Khan ST et al. ( 2015 ) . The Endothelial Transcription Factor ERG Promotes Vascular Stability and Growth through Wnt/β-Catenin Signaling . Developmental Cell vol. 32 , ( 1 ) 82 - 96 .
Browne AK, Tookman LA, Ingemarsdotter CK, Bouwman R, Pirlo K, Wang Y, Hodivala-Dilke KM, McNeish IA et al. ( 2014 ) . 106 Beta-3 integrin inhibition reduces inflammatory cytokine release but not anti-cancer activity of oncolytic adenovirus in ovarian cancer . European Journal of Cancer . vol. 50 ,
Tavora B, Batista S, Alexopoulou AN, Kostourou V, Fernandez I, Robinson SD, Lees DM, Serrels B et al. ( 2014 ) . Generation of point-mutant FAK knockin mice . Genesis vol. 52 , ( 11 ) 907 - 915 .
Tavora B, Reynolds LE, Batista S, Demircioglu F, Fernandez I, Lechertier T, Lees DM, Wong P-P et al. ( 2014 ) . Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy . Nature vol. 514 , ( 7520 ) 112 - 116 .
Batista S, Maniati E, Reynolds LE, Tavora B, Lees DM, Fernandez I, Elia G, Casanovas O et al. ( 2014 ) . Haematopoietic focal adhesion kinase deficiency alters haematopoietic homeostasis to drive tumour metastasis . Nat Commun vol. 5 ,
Moore AD, Hodgkinson C, Lapenna A, Zhang F, Witkowska K, Liang Ng F, Headland SE, Reynolds L et al. ( 2014 ) . 203 Hypoxia-inducible Factor-1 Regulates Matrix Metalloproteinase-14 Expression: Underlying Effects of Hypoxia and Statins . Heart . vol. 100 Suppl 3 , A111 - A112 .
Alexopoulou AN, Ho-Yen CM, Papalazarou V, Elia G, Jones JL, Hodivala-Dilke K ( 2014 ) . Tumour-associated endothelial-FAK correlated with molecular sub-type and prognostic factors in invasive breast cancer . BMC Cancer vol. 14 ,
Steri V, Ellison TS, Gontarczyk AM, Weilbaecher K, Schneider JG, Edwards D, Fruttiger M, Hodivala-Dilke KM et al. ( 2014 ) . Acute depletion of endothelial β3-integrin transiently inhibits tumor growth and angiogenesis in mice . Circulation Research vol. 114 , ( 1 ) 79 - 91 .
Shah AV, Birdsey GM, Reynolds LE, Dufton N, Almagro LO, Yang Y, Aspalter IM, Khan ST et al. ( 2014 ) . The endothelial transcription factor ERG promotes vascular stability and growth through Wnt/β-catenin signaling . ANGIOGENESIS vol. 17 , ( 3 ) 715 - 715 .
Martino-Echarri E, Fernández-Rodríguez R, Rodríguez-Baena FJ, Barrientos-Durán A, Torres-Collado AX, Plaza-Calonge MDC, Amador-Cubero S, Cortés J et al. ( 2013 ) . Contribution of ADAMTS1 as a tumor suppressor gene in human breast carcinoma. Linking its tumor inhibitory properties to its proteolytic activity on nidogen-1 and nidogen-2 . Int J Cancer vol. 133 , ( 10 ) 2315 - 2324 .
Fokas E, Lechterier T, Hackl W, S-M M, McKenna WG, Hodivala-Dilke K, Muschel RJ ( 2013 ) . Dose- and schedule-dependent changes in vascular morphology after PI3K and PI3K/mTOR inhibition: in vitro vs. in vivo effects . STRAHLENTHERAPIE UND ONKOLOGIE . vol. 189 , 41 - 41 .
Jones DT, Lechertier T, Reynolds LE, Mitter R, Robinson SD, Kirn-Safran CB, Hodivala-Dilke KM ( 2013 ) . Endogenous ribosomal protein L29 (RPL29): a newly identified regulator of angiogenesis in mice . Dis Model Mech vol. 6 , ( 1 ) 115 - 124 .
Kostourou V, Lechertier T, Reynolds LE, Lees DM, Baker M, Jones DT, Tavora B, Ramjaun AR et al. ( 2013 ) . FAK-heterozygous mice display enhanced tumour angiogenesis . Nat Commun vol. 4 ,
Ma Y, Reynolds LE, Li A, Stevenson RP, Hodivala-Dilke KM, Yamashiro S, Machesky LM ( 2013 ) . Fascin 1 is dispensable for developmental and tumour angiogenesis . Biol Open vol. 2 , ( 11 ) 1187 - 1191 .
Baker M, Reynolds LE, Robinson SD, Lees DM, Parsons M, Elia G, Hodivala-Dilke K ( 2013 ) . Stromal Claudin14-heterozygosity, but not deletion, increases tumour blood leakage without affecting tumour growth . PLoS One vol. 8 , ( 5 )
Lechertier T, Hodivala-Dilke K ( 2012 ) . Focal adhesion kinase and tumour angiogenesis . J Pathol vol. 226 , ( 2 ) 404 - 412 .
Jones DT, Lechertier T, Mitter R, Herbert JMJ, Bicknell R, Jones JL, Li J-L, Buffa F et al. ( 2012 ) . Gene expression analysis in human breast cancer associated blood vessels . PLoS One vol. 7 , ( 10 )
Ross J, Lechertier T, Morgan J, Muntoni F, Hodivala-Dilke K, Conti F ( 2012 ) . Roles of α3-integrin in development of the neuromuscular system . NEUROMUSCULAR DISORDERS . vol. 22 , S11 - S11 .
Dreger SA, Payne SJ, Dawoud M, Robinson SD, Marshall JF, Hodivala-Dilke KM, Allen MD, Jones JL ( 2012 ) . Up-regulation of αvβ6 integrin and fibronectin EDA in myoepithelial cells contribute to the angiogenic switch in pre-invasive breast cancer . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 93 , A24 - A24 .
Baker M, Robinson SD, Lechertier T, Barber PR, Tavora B, D'Amico G, Jones DT, Vojnovic B et al. ( 2011 ) . Use of the mouse aortic ring assay to study angiogenesis . Nat Protoc vol. 7 , ( 1 ) 89 - 104 .
Robinson SD, Hodivala-Dilke KM ( 2011 ) . The role of β3-integrins in tumor angiogenesis: context is everything . Curr Opin Cell Biol vol. 23 , ( 5 ) 630 - 637 .
Tavora B, Hodivala-dilke K ( 2011 ) . Abstract 3472: Endothelial FAK is required for tumor angiogenesis . Cancer Research . vol. 71 , 3472 - 3472 .
Baker M, Robinson SD, Hodivala-Dilke K, Ben-Yosef T ( 2011 ) . Abstract 3479: Claudin-14: A novel regulator of angiogenesis . Cancer Research vol. 71 , ( 8_Supplement ) 3479 - 3479 .
Jones DT, Lechertier T, Herbert J, Bicknell R, Jones LJ, Harris AL, Hodivala-Dilke K ( 2011 ) . Abstract 4848: Genetic profile of invasive breast cancer vasculature using laser capture microdissection (LCM) to capture vessels . Cancer Research . vol. 71 , 4848 - 4848 .
Batista SA, Reynolds L, Tavora B, Hodivala-Dilke K ( 2011 ) . Abstract 517: Deficiency of FAK in the bone marrow compartment enhances tumour metastasis . Cancer Research vol. 71 , ( 8_Supplement ) 517 - 517 .
Hodivala-Dilke KM ( 2011 ) . Abstract SY16-03: Dose matters and angiogenesis . Cancer Research vol. 71 , ( 8_Supplement )
Hodivala-Dilke KM ( 2011 ) . Dose matters and angiogenesis . CANCER RESEARCH vol. 71 ,
Tavora B, Batista S, Hodivala-Dilke K ( 2011 ) . Measuring angiogenesis in mice . Methods Mol Biol vol. 769 , 351 - 358 .
Tavora B, Batista S, Reynolds LE, Jadeja S, Robinson S, Kostourou V, Hart I, Fruttiger M et al. ( 2010 ) . Endothelial FAK is required for tumour angiogenesis . EMBO Mol Med vol. 2 , ( 12 ) 516 - 528 .
da Silva RG, Tavora B, Robinson SD, Reynolds LE, Szekeres C, Lamar J, Batista S, Kostourou V et al. ( 2010 ) . Endothelial alpha3beta1-integrin represses pathological angiogenesis and sustains endothelial-VEGF . Am J Pathol vol. 177 , ( 3 ) 1534 - 1548 .
Reynolds LE, Watson AR, Baker M, Jones TA, D'Amico G, Robinson SD, Joffre C, Garrido-Urbani S et al. ( 2010 ) . Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome (Corrigendum) . NATURE vol. 466 , ( 7304 )
Reynolds LE, Watson AR, Baker M, Jones TA, D'Amico G, Robinson SD, Joffre C, Garrido-Urbani S et al. ( 2010 ) . Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome . Nature vol. 465 , ( 7299 ) 813 - 817 .
Worth DC, Hodivala-Dilke K, Robinson SD, King SJ, Morton PE, Gertler FB, Humphries MJ, Parsons M ( 2010 ) . Alpha v beta3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration . J Cell Biol vol. 189 , ( 2 ) 369 - 383 .
D'Amico G, Robinson SD, Germain M, Reynolds LE, Thomas GJ, Elia G, Saunders G, Fruttiger M et al. ( 2010 ) . Endothelial-Rac1 is not required for tumor angiogenesis unless alphavbeta3-integrin is absent . PLoS One vol. 5 , ( 3 )
Watson AR, Pitchford SC, Reynolds LE, Direkze N, Brittan M, Alison MR, Rankin S, Wright NA et al. ( 2010 ) . Deficiency of bone marrow beta3-integrin enhances non-functional neovascularization . J Pathol vol. 220 , ( 4 ) 435 - 445 .
Germain M, De Arcangelis A, Robinson SD, Baker M, Tavora B, D'Amico G, Silva R, Kostourou V et al. ( 2010 ) . Genetic ablation of the alpha 6-integrin subunit in Tie1Cre mice enhances tumour angiogenesis . J Pathol vol. 220 , ( 3 ) 370 - 381 .
D'Amico G, Jones DT, Nye E, Sapienza K, Ramjuan AR, Reynolds LE, Robinson SD, Kostourou V et al. ( 2010 ) . Regulation of lymphatic-blood vessel separation by endothelial Rac1 (vol 136, pg 4043, 2009) . DEVELOPMENT vol. 137 , ( 2 ) 359 - 359 .
Dawoud MM, Jones D, Hodivala-Dilke K, Dreger S, Chelala C, Asaad NY, Jones L ( 2009 ) . Microenvironmental Changes in DCIS: Myoepithelial Cells Change from Tumour Suppressor to Tumour Promoter . CANCER RESEARCH . vol. 69 , 760S - 760S .
Robinson SD, Reynolds LE, Kostourou V, Reynolds AR, da Silva RG, Tavora B, Baker M, Marshall JF et al. ( 2009 ) . Alphav beta3 integrin limits the contribution of neuropilin-1 to vascular endothelial growth factor-induced angiogenesis . J Biol Chem vol. 284 , ( 49 ) 33966 - 33981 .
D'Amico G, Jones DT, Nye E, Sapienza K, Ramjuan AR, Reynolds LE, Robinson SD, Kostourou V et al. ( 2009 ) . Regulation of lymphatic-blood vessel separation by endothelial Rac1 . Development vol. 136 , ( 23 ) 4043 - 4053 .
Braga VMM, Hodivala KJ, Watt FM ( 2009 ) . Calcium-Induced Changes in Distribution and Solubility of Cadherins, Integrins and Their Associated Cytoplasmic Proteins in Human Keratinocytes . Cell Communication & Adhesion vol. 3 , ( 3 ) 201 - 215 .
Reynolds AR, Hodivala-Dilke KM ( 2009 ) . Will integrin inhibitors have proangiogenic effects in the clinic? Reply . NAT MED vol. 15 , ( 7 ) 727 - 727 .
Suhrbier A, Wiser MF, Winger L, Harte P, Newton MF, Hodivala KJ, Nicholas J, Sinden RE ( 2009 ) . Contrasts in antigen expression in the erythrocytic and exoerythrocytic stages of rodent malaria . Parasitology vol. 99 , ( 2 ) 165 - 170 .
Watson AR, Schier S, Wright NA, Hodivala-Dilke KM ( 2009 ) . BETA3-INTEGRIN DEFICIENCY IN BONE MARROW ENHANCES ANGIOGENESIS IN A MOUSE MODEL OF PANCREATIC CANCER . GUT . vol. 58 , A114 - A114 .
Reynolds AR, Hart IR, Watson AR, Welti JC, Silva RG, Robinson SD, Da Violante G, Gourlaouen M et al. ( 2009 ) . Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors . Nat Med vol. 15 , ( 4 ) 392 - 400 .
Ramjaun AR, Hodivala-Dilke K ( 2009 ) . The role of cell adhesion pathways in angiogenesis . Int J Biochem Cell Biol vol. 41 , ( 3 ) 521 - 530 .
Silva R, D'Amico G, Hodivala-Dilke KM, Reynolds LE ( 2008 ) . Integrins - The keys to unlocking angiogenesis . ARTERIOSCL THROM VAS vol. 28 , ( 10 ) 1703 - 1713 .
Hodivala-Dilke K ( 2008 ) . alpha v beta 3 integrin and angiogenesis: a moody integrin in a changing environment . CURR OPIN CELL BIOL vol. 20 , ( 5 ) 514 - 519 .
Schier S, Watson A, Hodivala-Dilke K, Wright NA ( 2008 ) . The role of beta 3-integrin on bone marrow-derived cells in inflammatory bowel diseases . GASTROENTEROLOGY vol. 134 , ( 4 ) A257 - A257 .
Reynolds LE, Conti FJ, Silva R, Robinson SD, Iyer V, Rudling R, Cross B, Nye E et al. ( 2008 ) . alpha3beta1 integrin-controlled Smad7 regulates reepithelialization during wound healing in mice . J Clin Invest vol. 118 , ( 3 ) 965 - 974 .
Claxton S, Kostourou V, Jadeja S, Chambon P, Hodivala-Dilke K, Fruttiger M ( 2008 ) . Efficient, inducible Cre-recombinase activation in vascular endothelium . GENESIS vol. 46 , ( 2 ) 74 - 80 .
Scott AN, Hetheridge C, Reynolds AR, Nayak V, Hodivala-Dilke K, Mellor H ( 2008 ) . Farnesyltransferase inhibitors target multiple endothelial cell functions in angiogenesis . Angiogenesis vol. 11 , ( 4 ) 337 - 346 .
SUHRBIER A, WINGER L, O'DOWD C, HODIVALA K, SINDEN RE ( 2007 ) . An antigen specific to the liver stage of rodent malaria recognized by a monoclonal antibody . Parasite Immunology vol. 12 , ( 4‐5 ) 473 - 481 .
Boosani CS, Mannam AP, Cosgrove D, Silva R, Hodivala-Dilke KM, Keshamouni VG, Sudhakar A ( 2007 ) . Regulation of COX-2-mediated signaling by alpha 3 type IV noncollagenous domain in tumor angiogenesis . BLOOD vol. 110 , ( 4 ) 1168 - 1177 .
Piqueras L, Reynolds AR, Hodivala-Dilke KM, Alfranca A, Redondo JM, Hatae T, Tanabe T, Warner TD et al. ( 2007 ) . Activation of PPARbeta/delta induces endothelial cell proliferation and angiogenesis . Arterioscler Thromb Vasc Biol vol. 27 , ( 1 ) 63 - 69 .
Lucas M, Stuart LM, Zhang A, Hodivala-Dilke K, Febbraio M, Silverstein R, Savill J, Lacy-Hulbert A ( 2006 ) . Requirements for apoptotic cell contact in regulation of macrophage responses . J IMMUNOL vol. 177 , ( 6 ) 4047 - 4054 .
Direkze NC, Jeffery R, Hodivala-Dilke K, Burke F, Hunt FT, Poulsom R, Balkwill F, Wright NA et al. ( 2006 ) . Bone marrow contributes to functionally active cells in tumour stroma . JOURNAL OF PATHOLOGY . vol. 210 , 1 - 1 .
Hodivala-Dilke KM, Reynolds L, Reynolds A, Robinson S, Wyder L, Lively J, Taverna D, Hynes R et al. ( 2006 ) . Evaluating the role of b3-integrins in angiogenesis . FASEB JOURNAL . vol. 20 , A22 - A22 .
Direkze NC, Jeffery R, Hodivala-Dilke K, Hunt T, Playford RJ, Elia G, Poulsom R, Wright NA et al. ( 2006 ) . Bone marrow-derived stromal cells express lineage-related messenger RNA species . Cancer Res vol. 66 , ( 3 ) 1265 - 1269 .
Robinson SD, Wilson S, Hodivala-Dilke KM ( 2006 ) . Generation of genetically modified embryonic stem cells for the development of knockout mouse animal model systems . Methods Mol Med vol. 120 , 465 - 477 .
Germain M, Silva R, Reynolds L, Robinson S, DiPersio M, Kreidberg J, Georges-Labouesse E, Hodivala-Dilke K ( 2006 ) . Novel roles for integrins in tumour angiogenesis . BREAST CANCER RESEARCH . vol. 8 , S3 - S3 .
Reynolds LE, Hodivala-Dilke KM ( 2006 ) . Primary mouse endothelial cell culture for assays of angiogenesis . Methods Mol Med vol. 120 , 503 - 509 .
Fang J, Hodivala-Dilke K, Johnson BD, Du LM, Hynes RO, White GC, Wilcox DA ( 2005 ) . Therapeutic expression of the platelet-specific integrin, alpha IIb beta 3, in a murine model for Glanzmann thrombasthenia . BLOOD vol. 106 , ( 8 ) 2671 - 2679 .
Lamagna C, Hodivala-Dilke KM, Imhof BA, Aurrand-Lions M ( 2005 ) . Antibody against junctional adhesion molecule-C inhibits angiogenesis and tumor growth . CANCER RES vol. 65 , ( 13 ) 5703 - 5710 .
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Brittan M, Braun KM, Reynolds LM, Conti FJ, Reynolds AR, Poulsom R, Alison MR, Wright NA et al. ( 2005 ) . Transplanted Bone marrow cells engraft within the mouse epidermis and proliferate with no evidence of cell fusion . JOURNAL OF PATHOLOGY . vol. 205 , 6 - 6 .
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Brittan M, Braun KM, Reynolds LE, Conti FJ, Reynolds AR, Poulsom R, Alison MR, Wright NA et al. ( 2005 ) . Bone marrow cells engraft within the epidermis and proliferate in vivo with no evidence of cell fusion . J Pathol vol. 205 , ( 1 ) 1 - 13 .
McLean GW, Komiyama NH, Serrels B, Asano H, Reynolds L, Conti F, Hodivala-Dilke K, Metzger D et al. ( 2004 ) . Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression . Genes Dev vol. 18 , ( 24 ) 2998 - 3003 .
Direkze NC, Hodivala-Dilke K, Jeffery R, Hunt T, Poulsom R, Oukrif D, Alison MR, Wright NA ( 2004 ) . Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts . Cancer Res vol. 64 , ( 23 ) 8492 - 8495 .
Reynolds AR, Reynolds LE, Nagel TE, Lively JC, Robinson SD, Hicklin DJ, Bodary SC, Hodivala-Dilke KM ( 2004 ) . Elevated Flk1 (vascular endothelial growth factor receptor 2) signaling mediates enhanced angiogenesis in beta3-integrin-deficient mice . Cancer Res vol. 64 , ( 23 ) 8643 - 8650 .
Robinson SD, Reynolds LE, Wyder L, Hicklin DJ, Hodivala-Dilke KM ( 2004 ) . Beta3-integrin regulates vascular endothelial growth factor-A-dependent permeability . Arterioscler Thromb Vasc Biol vol. 24 , ( 11 ) 2108 - 2114 .
Direkze NC, Hodivala-Dilke K, Jeffery R, Hunt T, Oukrif D, Preston SL, Alison MR, Wright NA ( 2004 ) . Bone marrow contributes to tumour stroma . JOURNAL OF PATHOLOGY . vol. 204 , 10A - 10A .
Direkze NC, Hodivala-Dilke K, Jeffery R, Hunt T, Preston SL, Alison MR, Wright NA ( 2004 ) . Bone marrow contributes to tumour stroma . GASTROENTEROLOGY . vol. 126 , A134 - A135 .
Mistry A, Harbottle R, Hart S, Hodivala-Dilke KM ( 2003 ) . Integrins and angiogenesis: unlocking the route to gene therapy . Curr Opin Mol Ther vol. 5 , ( 6 ) 603 - 610 .
Petiot A, Conti FJA, Grose R, Revest J-M, Hodivala-Dilke KM, Dickson C ( 2003 ) . A crucial role for Fgfr2-IIIb signalling in epidermal development and hair follicle patterning . Development vol. 130 , ( 22 ) 5493 - 5501 .
Wan H, Stone MG, Simpson C, Reynolds LE, Marshall JF, Hart IR, Hodivala-Dilke KM, Eady RAJ ( 2003 ) . Desmosomal proteins, including desmoglein 3, serve as novel negative markers for epidermal stem cell-containing population of keratinocytes . J Cell Sci vol. 116 , ( Pt 20 ) 4239 - 4248 .
Alugupalli KR, Michelson AD, Joris I, Schwan TG, Hodivala-Dilke K, Hynes RO, Leong JM ( 2003 ) . Spirochete-platelet attachment and thrombocytopenia in murine relapsing fever borreliosis . Blood vol. 102 , ( 8 ) 2843 - 2850 .
Hodivala-Dilke KM, Reynolds AR, Reynolds LE ( 2003 ) . Integrins in angiogenesis: multitalented molecules in a balancing act . Cell Tissue Res vol. 314 , ( 1 ) 131 - 144 .
Direkze NC, Forbes SJ, Brittan M, Hunt T, Jeffery R, Preston SL, Poulsom R, Hodivala-Dilke K et al. ( 2003 ) . Bone marrow derived cells contribute to a population of fibroblasts and myofibroblasts which engraft to multiple sites, including the gastrointestinal tract . JOURNAL OF PATHOLOGY . vol. 201 , 6A - 6A .
Conti FJA, Rudling RJ, Robson A, Hodivala-Dilke KM ( 2003 ) . alpha3beta1-integrin regulates hair follicle but not interfollicular morphogenesis in adult epidermis . J Cell Sci vol. 116 , ( Pt 13 ) 2737 - 2747 .
Wilcox DA, Hodivala-Dilke KM, Johnson BD, Hynes RO, White GC ( 2003 ) . Therapeutic expression of a platelet-specific integrin, alpha IIb beta 3 . MOLECULAR THERAPY . vol. 7 , S157 - S157 .
Direkze NC, Forbes S, Brittan M, Hunt T, Jeffrey R, Preston S, Poulsom R, Hodivala-Dilke K et al. ( 2003 ) . Bone marrow derived cells contribute to a population of fibroblasts and myofibroblasts which engraft to multiple sites, including the gastrointestinal tract . GASTROENTEROLOGY . vol. 124 , A120 - A120 .
Direkze NC, Forbes SJ, Brittan M, Hunt T, Jeffery R, Preston SL, Poulsom R, Hodivala-Dilke K et al. ( 2003 ) . Multiple organ engraftment by bone-marrow-derived myofibroblasts and fibroblasts in bone-marrow-transplanted mice . Stem Cells vol. 21 , ( 5 ) 514 - 520 .
Reynolds AR, Moein Moghimi S, Hodivala-Dilke K ( 2003 ) . Nanoparticle-mediated gene delivery to tumour neovasculature . Trends Mol Med vol. 9 , ( 1 ) 2 - 4 .
Jones SM, Hunt T, Brittan M, Jeffery R, Forbes S, Hodivala-Dilke K, Alison M, Wright N et al. ( 2002 ) . Lung repair by haematopoietic stem cells (HSC) after bone marrow transplant (BMT) . THORAX . vol. 57 ,
Wilcox DA, Hodivala-Dilke KM, Johnson BD, Hynes RO, White GC ( 2002 ) . Lineage-specific correction of Glanzmann thrombasthenia by expression of a functional hybrid murine-human alpha IIb beta 3 integrin complex on the surface of platelets of beta 3-knockout mice . BLOOD . vol. 100 , 867A - 867A .
Wan H, Marshall J, Reynolds LE, Stone MG, McGrath JA, Hodivala-Dilke KM, Eady RAJ ( 2002 ) . Diversity of desmoplakin expression in basal palm keratinocytes: A possible clue to the identification of epidermal stem cells . J INVEST DERMATOL vol. 119 , ( 3 ) 714 - 714 .
Schulz O, Pennington DJ, Hodivala-Dilke K, Febbraio M, Reis e Sousa C ( 2002 ) . CD36 or alphavbeta3 and alphavbeta5 integrins are not essential for MHC class I cross-presentation of cell-associated antigen by CD8 alpha+ murine dendritic cells . J Immunol vol. 168 , ( 12 ) 6057 - 6065 .
Brittan M, Hunt T, Jeffery R, Poulsom R, Forbes SJ, Hodivala-Dilke K, Goldman J, Alison MR et al. ( 2002 ) . Bone marrow derivation of pericryptal myofibroblasts in the mouse and human small intestine and colon . Gut vol. 50 , ( 6 ) 752 - 757 .
Francis SE, Goh KL, Hodivala-Dilke K, Bader BL, Stark M, Davidson D, Hynes RO ( 2002 ) . Central roles of alpha5beta1 integrin and fibronectin in vascular development in mouse embryos and embryoid bodies . Arterioscler Thromb Vasc Biol vol. 22 , ( 6 ) 927 - 933 .
Brittan M, Hunt T, Jeffery R, Poulsom R, Forbes S, Hodivala-Dilke K, Alison M, Wright NA ( 2002 ) . Bone marrow derivation of intestinal subepithelial myofibroblasts in the mouse and human small intestine and colon . GASTROENTEROLOGY vol. 122 , ( 4 ) A95 - A96 .
Forbes SJ, Hunt T, Brittan M, Jeffery R, Poulsom R, Hodivala-Dilke K, Alison MR, Wright NA ( 2002 ) . Bone marrow derivation of pericryptal myofibroblasts in the mouse and human small intestine and colon . GUT vol. 50 , A35 - A35 .
Reynolds LE, Wyder L, Lively JC, Taverna D, Robinson SD, Huang X, Sheppard D, Hynes RO et al. ( 2002 ) . Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins . Nat Med vol. 8 , ( 1 ) 27 - 34 .
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Hodivala-Dilke K ( 2001 ) . Sticky science is skin deep . Journal of Cell Science vol. 114 , ( 20 ) 3582 - 3582 .
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Forbes SJ, Hodivala-Dilke KM, Jeffery R, Alison MR, Poulsom R, Thomas H, Wright NA ( 2001 ) . Hepatocytes derived from bone marrow stem cells demonstrate polyploidisation . J HEPATOL vol. 34 , 20 - 21 .
Forbes SJ, Hodivala-Dilke KM, Jeffery R, Hunt T, Alison MR, Poulsom R, Wright NA ( 2001 ) . Hepatocytes derived from bone marrow stem cells show polyploidization in humans and mice . GUT vol. 48 , A65 - A66 .
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