Publications:  Dr David Gould

Sindeeva OA, Kopach O, Kurochkin MA, Sapelkin A, Gould DJ, Rusakov DA, Sukhorukov GB(2020). Polylactic Acid-Based Patterned Matrixes for Site-Specific Delivery of Neuropeptides On-Demand: Functional NGF Effects on Human Neuronal Cells. Frontiers in Bioengineering and Biotechnology vol. 8,

Young E, Gould DJ, Hart SL (2020). Targeted Non-Viral Delivery of Mini-Intronic Plasmids for Rheumatoid Arthritis. MOLECULAR THERAPY. vol. 28, 471-471.

Read JE, Luo D, Chowdhury TT, Flower RJ, Poston RN, Sukhorukov GB, Gould DJ(2020). Magnetically responsive layer-by-layer microcapsules can be retained in cells and under flow conditions to promote local drug release without triggering ROS production. Nanoscale vol. 12, (14) 7735-7748.

Young E, Gould D, Hart S(2020). Toward gene therapy in rheumatoid arthritis. Expert Review of Precision Medicine and Drug Development1-11.

Luo D, Poston RN, Gould DJ, Sukhorukov GB(2019). Magnetically targetable microcapsules display subtle changes in permeability and drug release in response to a biologically compatible low frequency alternating magnetic field. Materials Science and Engineering C vol. 94, 647-655.

Popov AL, Popova N, Gould DJ, Shcherbakov AB, Sukhorukov GB, Ivanov VK(2018). Ceria Nanoparticles-Decorated Microcapsules as a Smart Drug Delivery/Protective System: Protection of Encapsulated P. pyralis Luciferase. ACS Appl Mater Interfaces vol. 10, (17) 14367-14377.

Gai M, Kurochkin MA, Li D, Khlebtsov BN, Dong L, Tarakina N, Poston R, Gould DJ et al.(2018). In-situ NIR-laser mediated bioactive substance delivery to single cell for EGFP expression based on biocompatible microchamber-arrays. J Control Release vol. 276, 84-92.

Schultz CMA, Mullen L, Gould DJ, Chernajovsky Y (2017). Progranulin and derivatives can be employed as latent dual-function chondrogenic and anti-inflammatory therapeutics for the treatment of arthritis. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 98, A11-A11.

Gould D(2017). Mammalian Synthetic Promoters. Humana Press

Timin AS, Gould DJ, Sukhorukov GB(2017). Multi-layer microcapsules: fresh insights and new applications. Expert Opin Drug Deliv vol. 14, (5) 583-587.

Yousaf N, Gould D(2017). Demonstrating Interactions of Transcription Factors with DNA by Electrophoretic Mobility Shift Assay. vol. 1651,

Gould D(2017). Initial Considerations Before Designing a Promoter Construct. vol. 1651,

Mohamed H, Gould D(2017). PCR Assembly of Synthetic Promoters. vol. 1651,

Yousaf N, Gould D(2017). The Tetracycline Responsive System.

CATTELL MJ, Sukhorukov G, Gould DJ, shahid S, Zhang, X, Luo DONG(2016). Electrospun poly (lactic acid) fibers containing novel chlorhexidine particles with sustained antibacterial activity. Biomaterials Science

Svenskaya YI, Pavlov AM, Gorin DA, Gould DJ, Parakhonskiy BV, Sukhorukov GB(2016). Photodynamic therapy platform based on localized delivery of photosensitizer by vaterite submicron particles. Colloids Surf B Biointerfaces vol. 146, 171-179.

Mohamed H, Chernajovsky Y, Gould D(2016). Assembly PCR synthesis of optimally designed, compact, multi-responsive promoters suited to gene therapy application. Scientific Reports vol. 6, 29388-29388.

Luo D, Gould DJ, Sukhorukov GB(2016). Local and Sustained Activity of Doxycycline Delivered with Layer-by-Layer Microcapsules. Biomacromolecules vol. 17, (4) 1466-1476.

Subang MC, Fatah R, Wu Y, Hannaman D, Rice J, Evans CF, Chernajovsky Y, Gould D(2015). Effects of APC de-targeting and GAr modification on the duration of luciferase expression from plasmid DNA delivered to skeletal muscle. Current Gene Therapy vol. 15, (1) 3-14.

Pavlov AM, Gabriel SA, Sukhorukov GB, Gould DJ(2015). Improved and targeted delivery of bioactive molecules to cells with magnetic layer-by-layer assembled microcapsules. Nanoscale vol. 7, (21) 9686-9693.

Mullen L, Adams G, Foster J, Vessillier S, Köster M, Hauser H, Layward L, Gould D et al.(2014). A comparative study of matrix metalloproteinase and aggrecanase mediated release of latent cytokines at arthritic joints. Ann Rheum Dis vol. 73, (9) 1728-1736.

Muhammad H, Taher T, Mullen L, Pastan I, Marshall J, Chernajovsky Y, Gould D, Mageed R (2014). Development of a novel approach for targeted delivery of siRNA to B lymphocytes with a potential application in cancer. HUMAN GENE THERAPY. vol. 25, A5-A5.

Mohamed H, Chernajovsky Y, Gould D (2014). Development of novel transcriptionally responsive synthetic promoters for therapeutic gene expression during disease activity. HUMAN GENE THERAPY. vol. 25, A8-A8.

Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Lin D, Marzec J, Vasiljevi¿ N, Chaplin T et al.(2014). Identification of ZDHHC14 as a novel human tumour suppressor gene. J Pathol vol. 232, (5) 566-577.

Koutsokeras A, Purkayastha N, Rigby A, Subang MC, Sclanders M, Vessillier S, Mullen L, Chernajovsky Y et al.(2014). Erratum: Generation of an efficiently secreted, cell penetrating NF-?B inhibitor (FASEB Journal (2014) 28 (373-381) DOI: 10.1096/fj.13-236570). FASEB Journal vol. 28, (6)

Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Lin D, Marzec J, Vasiljevíc N, Chaplin T et al.(2014). Erratum:Identification of ZDHHC14 as a novel human tumour suppressor gene. J Pathol (2014); 232: 566-577)). Journal of Pathology vol. 234, (1)

Koutsokeras A, Purkayastha N, Rigby A, Subang MC, Sclanders M, Vessillier S, Mullen L, Chernajovsky Y et al.(2014). Generation of an efficiently secreted, cell penetrating NF-κB inhibitor. FASEB J vol. 28, (1) 373-381.

Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Marzec J, Vasiljevic N, Chaplin T, Foster JM et al.(2014). Identification of ZDHHC14 as a novel human tumour suppressor: gene. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE vol. 34, S90-S90.

Mullen L, Rigby A, Sclanders M, Adams G, Mittal G, Colston J, Fatah R, Subang C et al.(2014). Latency can be conferred to a variety of cytokines by fusion with latency-associated peptide from TGF-β. Expert Opin Drug Deliv vol. 11, (1) 5-16.

Mullen L, Adams G, Layward L, Vessillier S, Annenkov A, Mittal G, Rigby A, Sclanders M et al.(2014). Latent cytokines for targeted therapy of inflammatory disorders. Expert Opin Drug Deliv vol. 11, (1) 101-110.

Pavlov AM, Sukhorukov GB, Gould DJ(2013). Location of molecules in layer-by-layer assembled microcapsules influences activity, cell delivery and susceptibility to enzyme degradation. J Control Release vol. 172, (1) 22-29.

Viale DL, Cafferata EG, Gould D, Rotondaro C, Chernajovsky Y, Curiel DT, Podhajcer OL, Veronica Lopez M(2013). Therapeutic improvement of a stroma-targeted CRAd by incorporating motives responsive to the melanoma microenvironment. J Invest Dermatol vol. 133, (11) 2576-2584.

Gould D(2013). Gene doping: gene delivery for olympic victory. Br J Clin Pharmacol vol. 76, (2) 292-298.

Mohamed H, Chernajovsky Y, Gould D (2013). Development of novel transciptionally responsive synthetic promoters for therapeutic gene expression during disease activity. HUMAN GENE THERAPY. vol. 24, A36-A36.

Muhammad H, Taher T, Mullen L, Pastan I, Chernajovsky Y, Gould D, Mageed R (2013). Generation of a secreted scFv for specific delivery of siRNA to B-lymphocytes. HUMAN GENE THERAPY. vol. 24, A36-A36.

Pavlov AM, Sukhorukov GB, Gould DJ(2013). Lessons in microcapsule assembly from imaging delivery of a bioluminescent enzyme. Biomacromolecules vol. 14, (3) 608-612.

Leinster DA, Kulbe H, Everitt G, Thompson R, Perretti M, Gavins FNE, Cooper D, Gould D et al.(2012). The peritoneal tumour microenvironment of high-grade serous ovarian cancer. J Pathol vol. 227, (2) 136-145.

Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Lin D, Chaplin T, Xue L, Xu M et al.(2012). Identification of ZDHHC14 as a novel tumor suppressor gene commonly downregulated in human cancers. CANCER RESEARCH vol. 72,

Subang MC, Fatah R, Bright C, Blanco P, Berenstein M, Wu Y, Podhajcer OL, Winyard PG et al.(2012). A novel hybrid promoter responsive to pathophysiological and pharmacological regulation. J Mol Med (Berl) vol. 90, (4) 401-411.

Hughes C, Faurholm B, Dell'Accio F, Manzo A, Seed M, Eltawil N, Marrelli A, Gould D et al. (2011). TARGETING THERAPEUTICS TO ARTHRITIC JOINTS. RHEUMATOLOGY. vol. 50, 127-127.

Battery L, Solomon A, Gould D(2011). Gene Doping: Olympic Genes for Olympic Dreams. J R Soc Med vol. 104, 494-500.

Stok KS, Noel D, Apparailly F, Gould D, Chernajovsky Y, Jorgensen C, Muller R(2010). Quantitative imaging of cartilage and bone for functional assessment of gene therapy approaches in experimental arthritis. J TISSUE ENG REGEN M vol. 4, (5) 387-394.

Hughes C, Faurholm B, Dell'Accio F, Manzo A, Seed M, Eltawil N, Marrelli A, Gould D et al.(2010). Human single-chain variable fragment that specifically targets arthritic cartilage. Arthritis Rheum vol. 62, (4) 1007-1016.

Subang MC, Gould D(2010). Delivery and application of Plasmid DNA in Arthritis Gene Therapy. Gene Therapy for Autoimmune and Inflammatory diseases’ Milestones in Drug Therapy, Editors: Chernajovsky, Y, Robbins, PD, BIRKHAUSER

Vilalta M, Jorgensen C, Degano IR, Chernajovsky Y, Gould D, Noel D, Andrades JA, Becerra J et al.(2009). Dual luciferase labelling for non-invasive bioluminescence imaging of mesenchymal stromal cell chondrogenic differentiation in demineralized bone matrix scaffolds. BIOMATERIALS vol. 30, (28) 4986-4995.

Jawad AS, Taher TE, Rahim A, D'Acquisto F, Gould D, Mageed RA (2009). SELECTIVE TARGETING OF THE CANONICAL OR ALTERNATIVE NF-kappa B PATHWAY REVEALS NEW INSIGHTS INTO MECHANISMS OF B-LYMPHOCYTE SURVIVAL AND SELECTION. RHEUMATOLOGY. vol. 48, I30-I31.

Lopez MV, Viale DL DL, Cafferata EG, Bravo AI, Carbone C, Gould D, Chernajovsky Y, Podhajcer OL(2009). Tumor associated stromal cells play a critical role on the outcome of the oncolytic efficacy of conditionally replicative adenoviruses. PLoS ONE vol. 4,

Vilalta M, Degano IR, Bago J, Gould D, Santos M, Garcia-Arranz M, Ayats R, Fuster C et al.(2008). Biodistribution, Long-term Survival, and Safety of Human Adipose Tissue-derived Mesenchymal Stem Cells Transplanted in Nude Mice by High Sensitivity Non-invasive Bioluminescence Imaging. STEM CELLS DEV vol. 17, (5) 993-1003.

Taher TE, Tulone C, Fatah R, D'Acquisto F, Gould DJ, Mageed RA(2008). Repopulation of B-lymphocytes with restricted gene expression using haematopoietic stem cells engineered with lentiviral vectors. Gene Ther vol. 15, (13) 998-1006.

Subang MC, Fatah R, Wu Y, Chernajovsky Y, Gould DJ (2008). Progress with the delivery of biologic molecules by gene therapy in arthritis using plasmid DNA. HUMAN GENE THERAPY. vol. 19, 418-418.

Subang MC, Rice J, Fatah R, Wu Y, Chernajovsky Y, Gould DJ (2008). Strategies to prevent immunogenicity of foreign intracellular proteins. HUMAN GENE THERAPY. vol. 19, 421-421.

Gould DJ, Chernajovsky Y(2007). Novel delivery methods to achieve immunomodulation. Curr Opin Pharmacol vol. 7, (4) 445-450.

Khoury M, Adriaansen J, Vervoordeldonk MJBM, Gould D, Chernajovsky Y, Bigey P, Bloquel C, Scherman D et al.(2007). Inflammation-inducible anti-TNF gene expression mediated by intra-articular injection of serotype 5 adeno-associated virus reduces arthritis. J GENE MED vol. 9, (7) 596-604.

Khoury M, Adriaansen J, Vervoordeldonk MJBM, Gould D, Chernajovsky Y, Bigey P, Bloquel C, Scherman D et al. (2007). Inflammation-inducible anti-TNF gene expression by intra-articular injection of serotype 5 adeno-associated virus reduces arthritis. ANNALS OF THE RHEUMATIC DISEASES. vol. 66, A56-A56.

Kulbe H, Thompson R, Wilson JL, Robinson S, Hagemann T, Fatah R, Gould D, Ayhan A et al.(2007). The inflammatory cytokine tumor necrosis factor-alpha generates an autocrine tumor-promoting network in epithelial ovarian cancer cells. CANCER RES vol. 67, (2) 585-592.

Gould D, Yousaf N, Fatah R, Subang MC, Chernajovsky Y(2007). Gene therapy with an improved doxycycline-regulated plasmid encoding a tumour necrosis factor-alpha inhibitor in experimental arthritis. ARTHRITIS RES THER vol. 9, (1) Article R7,

Adriaansen J, Khoury M, de Cortie CJ, Fallaux FJ, Bigey P, Scherman D, Gould D, Chernajovsky Y et al.(2007). Reduction of arthritis following intra-articular administration of an adeno-associated virus serotype 5 expressing a disease-inducible TNF blocking agent. Ann Rheum Dis vol. 66, 1143-1150.

Lopez MV, Blanco P, Viale DL, Cafferata EG, Carbone C, Gould D, Chernajovsky Y, Podhajcer OL(2006). Expression of a suicidal gene under control of the human secreted protein acidic and rich in cysteine (SPARC) promoter in tumor or stromal cells led to the inhibition of tumor cell growth. MOL CANCER THER vol. 5, (10) 2503-2511.

CHERNAJOVSKY Y, Gould D, Podhajcer OL, Cafferata EA, Carbone C, Viale D, Blanco P, Lopez MV(2006). Expression of suicidal gene under control of the human SPARC promoter in tumor or stromal cells led to the inhibition of tumor cell growth. Mol. Cancer Ther. vol. 5, (10) 2503-2511.

Adriaansen J, Khoury M, de Cortie K, Bigey P, Sherman D, Gould D, Chernajovsky Y, Jorgensen C et al. (2006). Suppression of inflammation following intra-articular gene therapy with recombinant AAV5-Chimeric TNFR-Ig vector under an inducible promoter in animal models of rheumatoid arthritis. ARTHRITIS AND RHEUMATISM. vol. 54, S176-S177.

Khoury M, Adriaansen J, Louis-Plence P, Noel D, Bigey P, de Cortie C, Gould D, Vervoordeldonk M et al.(2006). Amelioration of Arthritis after Local Delivery of an Adeno-Associated Virus Type 6 Expressing a TNF-Blocking Agent under a Disease-Inducible Promoter. MOLECULAR THERAPY vol. 13, S409-S409.

Hagemann T, GOULD DJ, Wilson J, Fatah R, Robinson S, Kulbe H, Thompson R, Blakwill F et al.(2006). The inflammatory cytokine TNF-á generates an autocrine tumor- promoting network in epithelial ovarian cancer cells. Cancer Res

Yousaf N, Gould DJ, Aganna E, Hammond L, Mirakian RM, Turner MD, Hitman GA, McDermott MF et al.(2005). Tumor necrosis factor receptor I from patients with tumor necrosis factor receptor-associated periodic syndrome interacts with wild-type tumor necrosis factor receptor I and induces ligand-independent NF-kappaB activation. Arthritis Rheum vol. 52, (9) 2906-2916.

Chernajovsky Y, Gould DJ, Podhajcer OL(2004). Gene therapy for autoimmune diseases: quo vadis?. Nat Rev Immunol vol. 4, (10) 800-811.

Gould DJ, Chernajovsky Y(2004). Endogenous GATA factors bind the core sequence of the tetO and influence gene regulation with the tetracycline system. Mol Ther vol. 10, (1) 127-138.

Gould DJ, Chernajovsky Y (2004). Application of regulatable vectors in gene therapy of experimental arthritis. ARTHRITIS RESEARCH & THERAPY. vol. 6, S27-S27.

CHERNAJOVSKY Y, Gould DJ, Podhajcer OL(2004). Genetic Interventions for the treatment of autoimmune diseases: Quo Vadis?. Nat Rev Immunol vol. 4, (10) 800-811.

Gould DJ, Bright C, Chernajovsky Y(2004). Inhibition of established collagen-induced arthritis with a tumour necrosis factor-alpha inhibitor expressed from a self-contained doxycycline regulated plasmid. Arthritis Res Ther vol. 6, (2) R103-R113.

Chernajovsky Y, Vessillier S, Adams G, Gofur Y, Subang MC, Annenkov A, Favorov P, Daly G et al.(2003). Development of new molecules, vectors and cells for therapy of arthritis. JOINT BONE SPINE vol. 70, (6) 474-476.

Gould DJ, Favorov P(2003). Vectors for the treatment of autoimmune disease. GENE THER vol. 10, (10) 912-927.

CHERNAJOVSKY Y, Gould D, Dreja H, Triantaphyllopoulos K(2003). Interferon-beta gene therapy for the treatment of arthritis. Methods Mol Biol. vol. 215, 171-180.

Gould DJ(2002). Inducible diabetes and transgene expression in a single mouse: a tool to elucidate autoimmune mechanisms. TRANSGENIC RES vol. 11, (6) 583-585.

Dai L, O'Shaughnessy MC, Gould D, Claxson A, Marklund S, Kidd B, Chernajovsky Y, Winyard PG(2002). SUPPRESSION OF INFLAMMATION BY ANTIOXIDANT GENE THERAPY IN AN ANTIGEN-INDUCED ARTHRITIS MODEL. RHEUMATOLOGY vol. 41, 34-34.

Gould DJ, Berenstein M, Dreja H, Ledda F, Podhajcer OL, Chernajovsky Y(2000). A novel doxycycline inducible autoregulatory plasmid which displays 'on'/'off' regulation suited to gene therapy applications. GENE THER vol. 7, (24) 2061-2070.

Chernajovsky Y, Dreja H, Daly G, Annenkov A, Gould D, Adams G, Croxford JL, Baker D et al.(2000). Immuno- and genetic therapy in autoimmune diseases. Genes Immun vol. 1, (5) 295-307.

Chernajovsky Y, Gould D, Annenkov A, Dreja H, Daly G, Rabinovich GA, Croxford L, Baker D et al.(1999). Immunotherapy of auto-immune diseases by gene transfer. Biochem Soc Trans vol. 27, (6) 869-873.

Chernajovsky Y, Annenkov A, Herman C, Triantaphyllopoulos K, Gould D, Dreja H, Moyes SP, Croxford JL et al.(1998). Gene therapy for rheumatoid arthritis. Theoretical considerations. Drugs and Aging vol. 12, (1) 29-41.