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Publications:  Dr David Gould

Sindeeva OA, Kopach O, Kurochkin MA, Sapelkin A, Gould DJ, Rusakov DA, Sukhorukov GB(2020). Polylactic Acid-Based Patterned Matrixes for Site-Specific Delivery of Neuropeptides On-Demand: Functional NGF Effects on Human Neuronal Cells. Frontiers in Bioengineering and Biotechnology vol. 8,
10.3389/fbioe.2020.00497
https://qmro.qmul.ac.uk/xmlui/handle/123456789/64402
Young E, Gould DJ, Hart SL (2020). Targeted Non-Viral Delivery of Mini-Intronic Plasmids for Rheumatoid Arthritis. MOLECULAR THERAPY. vol. 28, 471-471.
Read JE, Luo D, Chowdhury TT, Flower RJ, Poston RN, Sukhorukov GB, Gould DJ(2020). Magnetically responsive layer-by-layer microcapsules can be retained in cells and under flow conditions to promote local drug release without triggering ROS production. Nanoscale vol. 12, (14) 7735-7748.
10.1039/c9nr10329e
https://qmro.qmul.ac.uk/xmlui/handle/123456789/64585
Young E, Gould D, Hart S(2020). Toward gene therapy in rheumatoid arthritis. Expert Review of Precision Medicine and Drug Development1-11.
10.1080/23808993.2020.1736942
https://qmro.qmul.ac.uk/xmlui/handle/123456789/64587
Luo D, Poston RN, Gould DJ, Sukhorukov GB(2019). Magnetically targetable microcapsules display subtle changes in permeability and drug release in response to a biologically compatible low frequency alternating magnetic field. Materials Science and Engineering C vol. 94, 647-655.
10.1016/j.msec.2018.10.031
Popov AL, Popova N, Gould DJ, Shcherbakov AB, Sukhorukov GB, Ivanov VK(2018). Ceria Nanoparticles-Decorated Microcapsules as a Smart Drug Delivery/Protective System: Protection of Encapsulated P. pyralis Luciferase. ACS Appl Mater Interfaces vol. 10, (17) 14367-14377.
10.1021/acsami.7b19658
https://qmro.qmul.ac.uk/xmlui/handle/123456789/39323
Gai M, Kurochkin MA, Li D, Khlebtsov BN, Dong L, Tarakina N, Poston R, Gould DJ et al.(2018). In-situ NIR-laser mediated bioactive substance delivery to single cell for EGFP expression based on biocompatible microchamber-arrays. J Control Release vol. 276, 84-92.
10.1016/j.jconrel.2018.02.044
https://qmro.qmul.ac.uk/xmlui/handle/123456789/39107
Schultz CMA, Mullen L, Gould DJ, Chernajovsky Y (2017). Progranulin and derivatives can be employed as latent dual-function chondrogenic and anti-inflammatory therapeutics for the treatment of arthritis. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 98, A11-A11.
Gould D(2017). Mammalian Synthetic Promoters. Humana Press
Timin AS, Gould DJ, Sukhorukov GB(2017). Multi-layer microcapsules: fresh insights and new applications. Expert Opin Drug Deliv vol. 14, (5) 583-587.
10.1080/17425247.2017.1285279
https://qmro.qmul.ac.uk/xmlui/handle/123456789/21679
Yousaf N, Gould D(2017). Demonstrating Interactions of Transcription Factors with DNA by Electrophoretic Mobility Shift Assay. vol. 1651,
https://qmro.qmul.ac.uk/xmlui/handle/123456789/27283
Gould D(2017). Initial Considerations Before Designing a Promoter Construct. vol. 1651,
https://qmro.qmul.ac.uk/xmlui/handle/123456789/25768
Mohamed H, Gould D(2017). PCR Assembly of Synthetic Promoters. vol. 1651,
https://qmro.qmul.ac.uk/xmlui/handle/123456789/27143
Yousaf N, Gould D(2017). The Tetracycline Responsive System.
https://qmro.qmul.ac.uk/xmlui/handle/123456789/26027
CATTELL MJ, Sukhorukov G, Gould DJ, shahid S, Zhang, X, Luo DONG(2016). Electrospun poly (lactic acid) fibers containing novel chlorhexidine particles with sustained antibacterial activity. Biomaterials Science
10.1039/C6BM00646A
https://qmro.qmul.ac.uk/xmlui/handle/123456789/17813
Svenskaya YI, Pavlov AM, Gorin DA, Gould DJ, Parakhonskiy BV, Sukhorukov GB(2016). Photodynamic therapy platform based on localized delivery of photosensitizer by vaterite submicron particles. Colloids Surf B Biointerfaces vol. 146, 171-179.
10.1016/j.colsurfb.2016.05.090
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12785
Mohamed H, Chernajovsky Y, Gould D(2016). Assembly PCR synthesis of optimally designed, compact, multi-responsive promoters suited to gene therapy application. Scientific Reports vol. 6, 29388-29388.
10.1038/srep29388
https://qmro.qmul.ac.uk/xmlui/handle/123456789/19080
Luo D, Gould DJ, Sukhorukov GB(2016). Local and Sustained Activity of Doxycycline Delivered with Layer-by-Layer Microcapsules. Biomacromolecules vol. 17, (4) 1466-1476.
10.1021/acs.biomac.6b00070
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12765
Subang MC, Fatah R, Wu Y, Hannaman D, Rice J, Evans CF, Chernajovsky Y, Gould D(2015). Effects of APC de-targeting and GAr modification on the duration of luciferase expression from plasmid DNA delivered to skeletal muscle. Current Gene Therapy vol. 15, (1) 3-14.
10.2174/1566523214666141114204943
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12786
Pavlov AM, Gabriel SA, Sukhorukov GB, Gould DJ(2015). Improved and targeted delivery of bioactive molecules to cells with magnetic layer-by-layer assembled microcapsules. Nanoscale vol. 7, (21) 9686-9693.
10.1039/c5nr01261a
https://qmro.qmul.ac.uk/xmlui/handle/123456789/8808
Mullen L, Adams G, Foster J, Vessillier S, Köster M, Hauser H, Layward L, Gould D et al.(2014). A comparative study of matrix metalloproteinase and aggrecanase mediated release of latent cytokines at arthritic joints. Ann Rheum Dis vol. 73, (9) 1728-1736.
10.1136/annrheumdis-2013-203513
https://qmro.qmul.ac.uk/xmlui/handle/123456789/7482
Muhammad H, Taher T, Mullen L, Pastan I, Marshall J, Chernajovsky Y, Gould D, Mageed R (2014). Development of a novel approach for targeted delivery of siRNA to B lymphocytes with a potential application in cancer. HUMAN GENE THERAPY. vol. 25, A5-A5.
Mohamed H, Chernajovsky Y, Gould D (2014). Development of novel transcriptionally responsive synthetic promoters for therapeutic gene expression during disease activity. HUMAN GENE THERAPY. vol. 25, A8-A8.
Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Lin D, Marzec J, Vasiljevi¿ N, Chaplin T et al.(2014). Identification of ZDHHC14 as a novel human tumour suppressor gene. J Pathol vol. 232, (5) 566-577.
10.1002/path.4327
Koutsokeras A, Purkayastha N, Rigby A, Subang MC, Sclanders M, Vessillier S, Mullen L, Chernajovsky Y et al.(2014). Erratum: Generation of an efficiently secreted, cell penetrating NF-?B inhibitor (FASEB Journal (2014) 28 (373-381) DOI: 10.1096/fj.13-236570). FASEB Journal vol. 28, (6)
10.1096/fj.13-236570ERR
Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Lin D, Marzec J, Vasiljevíc N, Chaplin T et al.(2014). Erratum:Identification of ZDHHC14 as a novel human tumour suppressor gene. J Pathol (2014); 232: 566-577)). Journal of Pathology vol. 234, (1)
10.1002/path.4396
Koutsokeras A, Purkayastha N, Rigby A, Subang MC, Sclanders M, Vessillier S, Mullen L, Chernajovsky Y et al.(2014). Generation of an efficiently secreted, cell penetrating NF-κB inhibitor. FASEB J vol. 28, (1) 373-381.
10.1096/fj.13-236570
Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Marzec J, Vasiljevic N, Chaplin T, Foster JM et al.(2014). Identification of ZDHHC14 as a novel human tumour suppressor: gene. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE vol. 34, S90-S90.
Mullen L, Rigby A, Sclanders M, Adams G, Mittal G, Colston J, Fatah R, Subang C et al.(2014). Latency can be conferred to a variety of cytokines by fusion with latency-associated peptide from TGF-β. Expert Opin Drug Deliv vol. 11, (1) 5-16.
10.1517/17425247.2013.839655
Mullen L, Adams G, Layward L, Vessillier S, Annenkov A, Mittal G, Rigby A, Sclanders M et al.(2014). Latent cytokines for targeted therapy of inflammatory disorders. Expert Opin Drug Deliv vol. 11, (1) 101-110.
10.1517/17425247.2014.863872
Pavlov AM, Sukhorukov GB, Gould DJ(2013). Location of molecules in layer-by-layer assembled microcapsules influences activity, cell delivery and susceptibility to enzyme degradation. J Control Release vol. 172, (1) 22-29.
10.1016/j.jconrel.2013.08.002
Viale DL, Cafferata EG, Gould D, Rotondaro C, Chernajovsky Y, Curiel DT, Podhajcer OL, Veronica Lopez M(2013). Therapeutic improvement of a stroma-targeted CRAd by incorporating motives responsive to the melanoma microenvironment. J Invest Dermatol vol. 133, (11) 2576-2584.
10.1038/jid.2013.191
Gould D(2013). Gene doping: gene delivery for olympic victory. Br J Clin Pharmacol vol. 76, (2) 292-298.
10.1111/bcp.12010
Mohamed H, Chernajovsky Y, Gould D (2013). Development of novel transciptionally responsive synthetic promoters for therapeutic gene expression during disease activity. HUMAN GENE THERAPY. vol. 24, A36-A36.
Muhammad H, Taher T, Mullen L, Pastan I, Chernajovsky Y, Gould D, Mageed R (2013). Generation of a secreted scFv for specific delivery of siRNA to B-lymphocytes. HUMAN GENE THERAPY. vol. 24, A36-A36.
Pavlov AM, Sukhorukov GB, Gould DJ(2013). Lessons in microcapsule assembly from imaging delivery of a bioluminescent enzyme. Biomacromolecules vol. 14, (3) 608-612.
10.1021/bm3019054
Leinster DA, Kulbe H, Everitt G, Thompson R, Perretti M, Gavins FNE, Cooper D, Gould D et al.(2012). The peritoneal tumour microenvironment of high-grade serous ovarian cancer. J Pathol vol. 227, (2) 136-145.
10.1002/path.4002
https://qmro.qmul.ac.uk/xmlui/handle/123456789/13856
Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Lin D, Chaplin T, Xue L, Xu M et al.(2012). Identification of ZDHHC14 as a novel tumor suppressor gene commonly downregulated in human cancers. CANCER RESEARCH vol. 72,
10.1158/1538-7445.AM2012-4858
Subang MC, Fatah R, Bright C, Blanco P, Berenstein M, Wu Y, Podhajcer OL, Winyard PG et al.(2012). A novel hybrid promoter responsive to pathophysiological and pharmacological regulation. J Mol Med (Berl) vol. 90, (4) 401-411.
10.1007/s00109-011-0826-3
https://qmro.qmul.ac.uk/xmlui/handle/123456789/14350
Hughes C, Faurholm B, Dell'Accio F, Manzo A, Seed M, Eltawil N, Marrelli A, Gould D et al. (2011). TARGETING THERAPEUTICS TO ARTHRITIC JOINTS. RHEUMATOLOGY. vol. 50, 127-127.
Battery L, Solomon A, Gould D(2011). Gene Doping: Olympic Genes for Olympic Dreams. J R Soc Med vol. 104, 494-500.
10.1258/jrsm.2011.110240
Stok KS, Noel D, Apparailly F, Gould D, Chernajovsky Y, Jorgensen C, Muller R(2010). Quantitative imaging of cartilage and bone for functional assessment of gene therapy approaches in experimental arthritis. J TISSUE ENG REGEN M vol. 4, (5) 387-394.
10.1002/term.251
Hughes C, Faurholm B, Dell'Accio F, Manzo A, Seed M, Eltawil N, Marrelli A, Gould D et al.(2010). Human single-chain variable fragment that specifically targets arthritic cartilage. Arthritis Rheum vol. 62, (4) 1007-1016.
10.1002/art.27346
https://qmro.qmul.ac.uk/xmlui/handle/123456789/19241
Subang MC, Gould D(2010). Delivery and application of Plasmid DNA in Arthritis Gene Therapy. Gene Therapy for Autoimmune and Inflammatory diseases’ Milestones in Drug Therapy, Editors: Chernajovsky, Y, Robbins, PD, BIRKHAUSER
Vilalta M, Jorgensen C, Degano IR, Chernajovsky Y, Gould D, Noel D, Andrades JA, Becerra J et al.(2009). Dual luciferase labelling for non-invasive bioluminescence imaging of mesenchymal stromal cell chondrogenic differentiation in demineralized bone matrix scaffolds. BIOMATERIALS vol. 30, (28) 4986-4995.
10.1016/j.biomaterials.2009.05.056
Jawad AS, Taher TE, Rahim A, D'Acquisto F, Gould D, Mageed RA (2009). SELECTIVE TARGETING OF THE CANONICAL OR ALTERNATIVE NF-kappa B PATHWAY REVEALS NEW INSIGHTS INTO MECHANISMS OF B-LYMPHOCYTE SURVIVAL AND SELECTION. RHEUMATOLOGY. vol. 48, I30-I31.
Lopez MV, Viale DL DL, Cafferata EG, Bravo AI, Carbone C, Gould D, Chernajovsky Y, Podhajcer OL(2009). Tumor associated stromal cells play a critical role on the outcome of the oncolytic efficacy of conditionally replicative adenoviruses. PLoS ONE vol. 4,
Vilalta M, Degano IR, Bago J, Gould D, Santos M, Garcia-Arranz M, Ayats R, Fuster C et al.(2008). Biodistribution, Long-term Survival, and Safety of Human Adipose Tissue-derived Mesenchymal Stem Cells Transplanted in Nude Mice by High Sensitivity Non-invasive Bioluminescence Imaging. STEM CELLS DEV vol. 17, (5) 993-1003.
10.1089/scd.2007.0201
Taher TE, Tulone C, Fatah R, D'Acquisto F, Gould DJ, Mageed RA(2008). Repopulation of B-lymphocytes with restricted gene expression using haematopoietic stem cells engineered with lentiviral vectors. Gene Ther vol. 15, (13) 998-1006.
10.1038/gt.2008.33
Subang MC, Fatah R, Wu Y, Chernajovsky Y, Gould DJ (2008). Progress with the delivery of biologic molecules by gene therapy in arthritis using plasmid DNA. HUMAN GENE THERAPY. vol. 19, 418-418.
Subang MC, Rice J, Fatah R, Wu Y, Chernajovsky Y, Gould DJ (2008). Strategies to prevent immunogenicity of foreign intracellular proteins. HUMAN GENE THERAPY. vol. 19, 421-421.
Gould DJ, Chernajovsky Y(2007). Novel delivery methods to achieve immunomodulation. Curr Opin Pharmacol vol. 7, (4) 445-450.
10.1016/j.coph.2007.05.002
Khoury M, Adriaansen J, Vervoordeldonk MJBM, Gould D, Chernajovsky Y, Bigey P, Bloquel C, Scherman D et al.(2007). Inflammation-inducible anti-TNF gene expression mediated by intra-articular injection of serotype 5 adeno-associated virus reduces arthritis. J GENE MED vol. 9, (7) 596-604.
10.1002/jgm.1053
Khoury M, Adriaansen J, Vervoordeldonk MJBM, Gould D, Chernajovsky Y, Bigey P, Bloquel C, Scherman D et al. (2007). Inflammation-inducible anti-TNF gene expression by intra-articular injection of serotype 5 adeno-associated virus reduces arthritis. ANNALS OF THE RHEUMATIC DISEASES. vol. 66, A56-A56.
Kulbe H, Thompson R, Wilson JL, Robinson S, Hagemann T, Fatah R, Gould D, Ayhan A et al.(2007). The inflammatory cytokine tumor necrosis factor-alpha generates an autocrine tumor-promoting network in epithelial ovarian cancer cells. CANCER RES vol. 67, (2) 585-592.
10.1158/0008-5472.CAN-06-2941
Gould D, Yousaf N, Fatah R, Subang MC, Chernajovsky Y(2007). Gene therapy with an improved doxycycline-regulated plasmid encoding a tumour necrosis factor-alpha inhibitor in experimental arthritis. ARTHRITIS RES THER vol. 9, (1) Article R7,
10.1186/ar2113
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12795
Adriaansen J, Khoury M, de Cortie CJ, Fallaux FJ, Bigey P, Scherman D, Gould D, Chernajovsky Y et al.(2007). Reduction of arthritis following intra-articular administration of an adeno-associated virus serotype 5 expressing a disease-inducible TNF blocking agent. Ann Rheum Dis vol. 66, 1143-1150.
Lopez MV, Blanco P, Viale DL, Cafferata EG, Carbone C, Gould D, Chernajovsky Y, Podhajcer OL(2006). Expression of a suicidal gene under control of the human secreted protein acidic and rich in cysteine (SPARC) promoter in tumor or stromal cells led to the inhibition of tumor cell growth. MOL CANCER THER vol. 5, (10) 2503-2511.
10.1158/1535-7163.MCT-06-0286
CHERNAJOVSKY Y, Gould D, Podhajcer OL, Cafferata EA, Carbone C, Viale D, Blanco P, Lopez MV(2006). Expression of suicidal gene under control of the human SPARC promoter in tumor or stromal cells led to the inhibition of tumor cell growth. Mol. Cancer Ther. vol. 5, (10) 2503-2511.
Adriaansen J, Khoury M, de Cortie K, Bigey P, Sherman D, Gould D, Chernajovsky Y, Jorgensen C et al. (2006). Suppression of inflammation following intra-articular gene therapy with recombinant AAV5-Chimeric TNFR-Ig vector under an inducible promoter in animal models of rheumatoid arthritis. ARTHRITIS AND RHEUMATISM. vol. 54, S176-S177.
Khoury M, Adriaansen J, Louis-Plence P, Noel D, Bigey P, de Cortie C, Gould D, Vervoordeldonk M et al.(2006). Amelioration of Arthritis after Local Delivery of an Adeno-Associated Virus Type 6 Expressing a TNF-Blocking Agent under a Disease-Inducible Promoter. MOLECULAR THERAPY vol. 13, S409-S409.
10.1016/j.ymthe.2006.08.1165
Hagemann T, GOULD DJ, Wilson J, Fatah R, Robinson S, Kulbe H, Thompson R, Blakwill F et al.(2006). The inflammatory cytokine TNF-á generates an autocrine tumor- promoting network in epithelial ovarian cancer cells. Cancer Res
Yousaf N, Gould DJ, Aganna E, Hammond L, Mirakian RM, Turner MD, Hitman GA, McDermott MF et al.(2005). Tumor necrosis factor receptor I from patients with tumor necrosis factor receptor-associated periodic syndrome interacts with wild-type tumor necrosis factor receptor I and induces ligand-independent NF-kappaB activation. Arthritis Rheum vol. 52, (9) 2906-2916.
10.1002/art.21268
Chernajovsky Y, Gould DJ, Podhajcer OL(2004). Gene therapy for autoimmune diseases: quo vadis?. Nat Rev Immunol vol. 4, (10) 800-811.
10.1038/nri1459
Gould DJ, Chernajovsky Y(2004). Endogenous GATA factors bind the core sequence of the tetO and influence gene regulation with the tetracycline system. Mol Ther vol. 10, (1) 127-138.
10.1016/j.ymthe.2004.04.011
Gould DJ, Chernajovsky Y (2004). Application of regulatable vectors in gene therapy of experimental arthritis. ARTHRITIS RESEARCH & THERAPY. vol. 6, S27-S27.
10.1186/ar1125
CHERNAJOVSKY Y, Gould DJ, Podhajcer OL(2004). Genetic Interventions for the treatment of autoimmune diseases: Quo Vadis?. Nat Rev Immunol vol. 4, (10) 800-811.
Gould DJ, Bright C, Chernajovsky Y(2004). Inhibition of established collagen-induced arthritis with a tumour necrosis factor-alpha inhibitor expressed from a self-contained doxycycline regulated plasmid. Arthritis Res Ther vol. 6, (2) R103-R113.
10.1186/ar1036
https://qmro.qmul.ac.uk/xmlui/handle/123456789/19524
Chernajovsky Y, Vessillier S, Adams G, Gofur Y, Subang MC, Annenkov A, Favorov P, Daly G et al.(2003). Development of new molecules, vectors and cells for therapy of arthritis. JOINT BONE SPINE vol. 70, (6) 474-476.
10.1016/S1297-319X(03)00157-X
Gould DJ, Favorov P(2003). Vectors for the treatment of autoimmune disease. GENE THER vol. 10, (10) 912-927.
10.1038/sj.gt.3302018
CHERNAJOVSKY Y, Gould D, Dreja H, Triantaphyllopoulos K(2003). Interferon-beta gene therapy for the treatment of arthritis. Methods Mol Biol. vol. 215, 171-180.
10.1385/1-59259-345-3:171
Gould DJ(2002). Inducible diabetes and transgene expression in a single mouse: a tool to elucidate autoimmune mechanisms. TRANSGENIC RES vol. 11, (6) 583-585.
10.1023/a:1021162605249
Dai L, O'Shaughnessy MC, Gould D, Claxson A, Marklund S, Kidd B, Chernajovsky Y, Winyard PG(2002). SUPPRESSION OF INFLAMMATION BY ANTIOXIDANT GENE THERAPY IN AN ANTIGEN-INDUCED ARTHRITIS MODEL. RHEUMATOLOGY vol. 41, 34-34.
Gould DJ, Berenstein M, Dreja H, Ledda F, Podhajcer OL, Chernajovsky Y(2000). A novel doxycycline inducible autoregulatory plasmid which displays 'on'/'off' regulation suited to gene therapy applications. GENE THER vol. 7, (24) 2061-2070.
10.1038/sj.gt.3301354
Chernajovsky Y, Dreja H, Daly G, Annenkov A, Gould D, Adams G, Croxford JL, Baker D et al.(2000). Immuno- and genetic therapy in autoimmune diseases. Genes Immun vol. 1, (5) 295-307.
10.1038/sj.gene.6363683
Chernajovsky Y, Gould D, Annenkov A, Dreja H, Daly G, Rabinovich GA, Croxford L, Baker D et al.(1999). Immunotherapy of auto-immune diseases by gene transfer. Biochem Soc Trans vol. 27, (6) 869-873.
10.1042/bst0270869
Chernajovsky Y, Annenkov A, Herman C, Triantaphyllopoulos K, Gould D, Dreja H, Moyes SP, Croxford JL et al.(1998). Gene therapy for rheumatoid arthritis. Theoretical considerations. Drugs and Aging vol. 12, (1) 29-41.
10.2165/00002512-199812010-00004
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