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Publications:  Dr Fabian Flores-Borja

Rodríguez-López GM, Soria-Castro R, Campillo-Navarro M, Pérez-Tapia SM, Flores-Borja F, Wong-Baeza I, Muñoz-Cruz S, López-Santiago R et al.(2020). The histone deacetylase inhibitor valproic acid attenuates phospholipase Cγ2 and IgE-mediated mast cell activation. Journal of Leukocyte Biology
10.1002/JLB.3AB0320-547RR
https://qmro.qmul.ac.uk/xmlui/handle/123456789/65248
An Z, Flores-Borja F, Irshad S, Deng J, Ng T(2020). Pleiotropic Role and Bidirectional Immunomodulation of Innate Lymphoid Cells in Cancer. Frontiers in Immunology vol. 10,
10.3389/fimmu.2019.03111
https://qmro.qmul.ac.uk/xmlui/handle/123456789/63839
Evans R, Flores-Borja F, Nassiri S, Miranda E, Lawler K, Grigoriadis A, Monypenny J, Gillet C et al.(2019). Integrin-Mediated Macrophage Adhesion Promotes Lymphovascular Dissemination in Breast Cancer. Cell Reports vol. 27, (7) 1967-1978.e4.
10.1016/j.celrep.2019.04.076
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62200
Monypenny J, Milewicz H, Flores-Borja F, Weitsman G, Cheung A, Chowdhury R, Burgoyne T, Arulappu A et al.(2018). ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation. Cell Reports vol. 24, (3) 630-641.
10.1016/j.celrep.2018.06.066
https://qmro.qmul.ac.uk/xmlui/handle/123456789/61008
Ng T, Flores-Borja F, Alfano G, Barber P, Weitsman G, Wong F (2018). The use of exosome and immune profiling to analyze a phase 2 study on the addition of patritumab or placebo to cetuximab and a platinum agent for recurrent / metastatic head and neck cancer (R/M HNSCC) patients. JOURNAL OF CLINICAL ONCOLOGY. Conference: 2018 American Society of Clinical Oncology vol. 36,
10.1200/JCO.2018.36.15_suppl.6043
Eisenblaetter M, Flores-Borja F, Lee JJ, Wefers C, Smith H, Hueting R, Cooper MS, Blower PJ et al.(2017). Visualization of Tumor-Immune Interaction - Target-Specific Imaging of S100A8/A9 Reveals Pre-Metastatic Niche Establishment. Theranostics vol. 7, (9) 2392-2401.
10.7150/thno.17138
https://qmro.qmul.ac.uk/xmlui/handle/123456789/60676
Irshad S, Flores-Borja F, Lawler K, Monypenny J, Evans R, Male V, Gordon P, Cheung A et al.(2017). RORγt+ Innate Lymphoid Cells Promote Lymph Node Metastasis of Breast Cancers. Cancer Res vol. 77, (5) 1083-1096.
10.1158/0008-5472.CAN-16-0598
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59927
Flores-Borja F, Irshad S, Gordon P, Wong F, Sheriff I, Tutt A, Ng T(2016). Crosstalk between Innate Lymphoid Cells and Other Immune Cells in the Tumor Microenvironment. Journal of Immunology Research vol. 2016,
10.1155/2016/7803091
https://qmro.qmul.ac.uk/xmlui/handle/123456789/61375
Becker A, Hokamp NG, Zenker S, Flores-Borja F, Barzcyk K, Varga G, Roth J, Geyer C et al.(2015). Optical in vivo imaging of the alarmin S100A9 in tumor lesions allows for estimation of the individual malignant potential by evaluation of tumor-host cell interaction. Journal of Nuclear Medicine vol. 56, (3) 450-456.
10.2967/jnumed.114.146688
Irshad S, Lawler K, Flores-Borja F, Monypenny J, Evans R, Grigoriadis A, Fruhwirth G, Cheung A et al. (2014). Effect of lymphoid tissue inducer cells on lymphatic tumor cell invasion via activation of the RANKL/RANK axis within triple-negative breast cancers. JOURNAL OF CLINICAL ONCOLOGY. vol. 32,
10.1200/jco.2014.32.15_suppl.11082
Irshad S, Lawler K, Evans R, Flores-Borja F, Monypenny J, Grigoriadis A, Fruhwith G, Poland S et al. (2013). Lymphoid tissue inducer cells: Identification of a novel immune cell within the breast tumour microenvironment and its role in promoting tumour cell invasion. CANCER RESEARCH. vol. 73,
10.1158/0008-5472.SABCS13-P5-01-01
Taher TE, Muhammad HA, Rahim A, Flores-Borja F, Renaudineau Y, Isenberg DA, Mageed RA(2013). Aberrant B-lymphocyte responses in lupus: Inherent or induced and potential therapeutic targets. European Journal of Clinical Investigation vol. 43, (8) 866-880.
10.1111/eci.12111
Taher TE, Muhammad HA, Bariller E, Flores-Borja F, Renaudineau Y, Isenberg DA, Mageed RA(2013). B-lymphocyte signalling abnormalities and lupus immunopathology. International Reviews of Immunology vol. 32, (4) 428-444.
10.3109/08830185.2013.788648
Irshad S, Flores-Borja FF, Evans R, Fruhwirth G, Pitmilly JM, Poland S, Ameer-Beg S, Tutt A et al.(2013). Use of Live In-Vivo Lymphatic Imaging Techniques to Study the Effects of Immune Cell Interactions in a Syngeneic Mouse Model of Breast Cancer. Annals of Oncology vol. 24,
10.1093/annonc/mdt144.1
Flores-Borja F, Bosma A, Ng D, Reddy V, Ehrenstein MR, Isenberg DA, Mauri C(2013). CD19<sup>+</sup>CD24<sup>hi</sup>CD38<sup>hi</sup> B cells maintain regulatory T cells while limiting T<inf>H</inf>1 and T<inf>H</inf>17 differentiation. Science Translational Medicine vol. 5, (173)
10.1126/scitranslmed.3005407
Mauri C, Carter NA, Flores-Borja F, Blair PA (2010). More than T regs, the relevance of other lymphocytes. IMMUNOLOGY. vol. 131, 18-18.
Flores-Borja F, Cambridge G, Ng D, Turi M, Ehrenstein MR, Isenberg D, Mauri C (2010). Regulatory B cells prevent the differentiation of naive CD4(+)T-cells into TH1 and TH17 but favour FOXP3+Tregs development. IMMUNOLOGY. vol. 131, 62-63.
Taher TE, Parikh K, Flores-Borja F, Mletzko S, Isenberg DA, Peppelenbosch MP, Mageed RA(2010). Protein phosphorylation and kinome profiling reveal altered regulation of multiple signaling pathways in B lymphocytes from patients with systemic lupus erythematosus. Arthritis and Rheumatism vol. 62, (8) 2412-2423.
10.1002/art.27505
Jury EC, Flores-Borja F, Kalsi HS, Lazarus M, Isenberg DA, Mauri C, Ehrenstein MR(2010). Abnormal CTLA-4 function in T cells from patients with systemic lupus erythematosus. European Journal of Immunology vol. 40, (2) 569-578.
10.1002/eji.200939781
Blair PA, Noreña LY, Flores-Borja F, Rawlings DJ, Isenberg DA, Ehrenstein MR, Mauri C(2010). CD19<sup>+</sup>CD24<sup>hi</sup>CD38<sup>hi</sup> B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients. Immunity vol. 32, (1) 129-140.
10.1016/j.immuni.2009.11.009
Flores-Borja F, Jury EC, Mauri C, Ehrenstein MR(2008). Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis. Proceedings of the National Academy of Sciences of the United States of America vol. 105, (49) 19396-19401.
10.1073/pnas.0806855105
Jury EC, Flores-Borja F, Kalsi HS, Lazarus M, Isenberg DA, Mauri C, Ehrenstein MR (2008). Abnormal cytotoxic T lymphocyte antigen-4 function in lupus patients is associated with induction of defective Foxp3+Treg. IMMUNOLOGY. vol. 125, 38-38.
Jury EC, Flores-Borja F, Isenberg DA, Mauri C, Ehrenstein MR (2008). Abnormal CTLA-4 function in lupus patients is associated with induction of a defective population of FOXP3+regulatory T cells via TGF. RHEUMATOLOGY. vol. 47, II64-II64.
Flores-Borja F, Jury EC, Ehrenstein MR (2008). Defective CTLA-4 function in regulatory T cells from patients with rheumatoid arthritis: A potential target for therapy. RHEUMATOLOGY. vol. 47, II55-II55.
Flores-Borja F, Mauri C, Ehrenstein MR(2008). Restoring the balance: Harnessing regulatory T cells for therapy in rheumatoid arthritis. European Journal of Immunology vol. 38, (4) 934-937.
10.1002/eji.200738107
Jury EC, Flores-Borja F, Kabouridis PS(2007). Lipid rafts in T cell signalling and disease. SEMIN CELL DEV BIOL vol. 18, (5) 608-615.
10.1016/j.semcdb.2007.08.002
Flores-Borja F, Kabouridis PS, Jury EC, Isenberg DA, Mageed RA(2007). Altered lipid raft-associated proximal signaling and translocation of CD45 tyrosine phosphatase in B lymphocytes from patients with systemic lupus erythematosus. Arthritis Rheum vol. 56, (1) 291-302.
10.1002/art.22309
Flores-Borja F, Kabouridis PS, Jury EC, Isenberg DA, Mageed RA(2006). Lyn deficiency in B cells from patients with systemic lupus erythematosus: comment on the article by Flores-Borja et al - Reply. ARTHRITIS RHEUM vol. 54, (6) 2037-2038.
10.1002/art.21877
Flores-Borja F, Kabouridis PS, Jury EC, Isenberg DA, Mageed RA(2005). Decreased Lyn expression and translocation to lipid raft signaling domains in B lymphocytes from patients with systemic lupus erythematosus. Arthritis Rheum vol. 52, (12) 3955-3965.
10.1002/art.21416
Flores-Borja F, Kabouridis PS, Jury E, Isenberg D, Mageed RA (2005). Translocation of CD45 to lipid raft signalling domains and abnormal relocation during B-lymphocyte activation in SLE. RHEUMATOLOGY. vol. 44, I17-I17.
Jury EC, Kabouridis PS, Flores-Borja F, Mageed RA, Isenberg DA (2004). ALTERED LIPID RAFT EXPRESSION AND ASSOCIATED SIGNALLING IN T LYMPHOCYTES FROM PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS (SLE). RHEUMATOLOGY. vol. 43, 24-24.
Flores-Borja F, Kabouridis PS, Jury E, Isenberg D, Mageed RA (2004). ATYPICAL CO-LOCALISATION OF CD45 AND LYN TO LIPID RAFT SIGNALLING DOMAINS CORRELATES WITH B-LYMPHOCYTE HYPER RESPONSIVENESS IN PATIENTS WITH LUPUS. RHEUMATOLOGY. vol. 43, 108-108.
Jury EC, Kabouridis PS, Flores-Borja F, Mageed RA, Isenberg DA(2004). Altered lipid raft-associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus. J CLIN INVEST vol. 113, (8) 1176-1187.
10.1172/JCI200420345
Flores-Borja F, Kieszkievicz J, Church V, Francis-West PH, Schofield J, Rademacher TW, Lund T(2004). Genetic regulation of mouse glycosylphosphatidylinositol-phospholipase D. Biochimie vol. 86, (4-5) 275-282.
10.1016/j.biochi.2004.04.003
Jury EC, Kabouridis PS, Flores-Borja F, Mageed RA, Isenberg DA (2003). Abnormal co-localisation of CD45 and lipid rafts is associated with reduced LCK expression in T cells from patients with SLE. ARTHRITIS AND RHEUMATISM. vol. 48, S193-S193.
Flores-Borja F, Kabouridis PS, Jury E, Isenberg D, Mageed RA (2003). ANALYSIS OF LIPID RAFT-ASSOCIATED SIGNALLING MOLECULES IN B CELLS FROM NORMAL AND PATIENTS WITH SLE. RHEUMATOLOGY. vol. 42, 72-73.
Jury EC, Kabouridis PS, Flores-Borja F, Mageed RA, Isenberg DA (2003). CD45 IS ABNORMALLY ASSOCIATED WITH LIPID RAFTS IN T LYMPHOCYTES FROM PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS (SLE). RHEUMATOLOGY. vol. 42, 5-5.
Monroy-García A, Ortíz-Navarrete VF, Mora-García MDL, Flores-Borja F, Diaz-Quiñonez A, Isibasi-Araujo A, Trejo-Becerril C, Chacón-Salinas R et al.(1999). Identification of peptides presented by HLA class I molecules on cervical cancer cells with HPV-18 infection. Immunology Letters vol. 67, (3) 167-177.
10.1016/S0165-2478(98)00188-6
Flores-Borja F, Santiago E, Weiss-Steider B(1998). Fcγ receptors in health and disease. Revista de Investigacion Clinica vol. 50, (6) 529-540.
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