Publications: Dr David Collier

Collier DJ, Taylor M, Godec T, Shiel J, James R, Chowdury Y, Ebano P, Monk V et al. ( 2024 ) . Personalized Antihypertensive Treatment Optimization With Smartphone-Enabled Remote Precision Dosing of Amlodipine During the COVID-19 Pandemic (PERSONAL-CovidBP Trial) . Journal of the American Heart Association vol. 13 , ( 4 )

Gupta A, Whiteley WN, Godec T, Rostamian S, Ariti C, Mackay J, Whitehouse A, Janani L et al. ( 2024 ) . Legacy benefits of blood pressure treatment on cardiovascular events are primarily mediated by improved blood pressure variability: the ASCOT trial . European Heart Journal

Rajkumar CA, Foley MJ, Ahmed-Jushuf F, Nowbar AN, Simader FA, Davies JR, O'Kane PD, Haworth P et al. ( 2023 ) . A Placebo-Controlled Trial of Percutaneous Coronary Intervention for Stable Angina . New England Journal of Medicine vol. 389 , ( 25 ) 2319 - 2330 .

Madurasinghe VW, Knapp P, Eldridge S, Collier D, Treweek S, Rick J, Graffy J, Parker A et al. ( 2023 ) . Can we achieve better trial recruitment by presenting patient information through multimedia? Meta-analysis of ‘studies within a trial’ (SWATs) . BMC Medicine vol. 21 , ( 1 )

Clohisey S, Millar J, Shankar-Hari M, Aitkin E, Aravindan L, Armstrong R, Baillie JK, Biggs H et al. ( 2023 ) . GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 . Nature vol. 617 , ( 7962 ) 764 - 768 .

Schlaich MP, Bellet M, Weber MA, Danaietash P, Bakris GL, Flack JM, Dreier RF, Sassi-Sayadi M et al. ( 2022 ) . Dual endothelin antagonist aprocitentan for resistant hypertension (PRECISION): a multicentre, blinded, randomised, parallel-group, phase 3 trial . The Lancet vol. 400 , ( 10367 ) 1927 - 1937 .

Nowbar AN, Howard JP, Shun-Shin MJ, Rajkumar C, Foley M, Basu A, Goel A, Patel S et al. ( 2022 ) . Daily angina documentation versus subsequent recall: development of a symptom smartphone app . European Heart Journal - Digital Health vol. 3 , ( 2 ) 276 - 283 .

Florescu S, Stanciu D, Zaharia M, Kosa A, Codreanu D, Kidwai A, Masood S, Kaye C et al. ( 2022 ) . Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients With COVID-19 . JAMA vol. 327 , ( 13 ) 1247 - 1259 .

Nowbar AN, Rajkumar C, Foley M, Ahmed-Jushuf F, Howard JP, Seligman H, Petraco R, Sen S et al. ( 2022 ) . A double-blind randomised placebo-controlled trial of percutaneous coronary intervention for the relief of stable angina without antianginal medications: design and rationale of the ORBITA-2 trial . EuroIntervention vol. 17 , ( 18 ) 1490 - 1497 .

Taylor M, Godec T, Shiel J, James R, Chowdury Y, Ebano P, Monk V, Patel M et al. ( 2022 ) . WHOSE DOSE IS IT ANYWAY? INDIVIDUAL PATIENT DOSE-RESPONSE CURVES FROM THE REMOTE-CARE PERSONAL-COVIDBP TRIAL . Journal of the American College of Cardiology vol. 79 , ( 9 )

Astbury S, Reynolds CJ, Butler DK, Muñoz‐Sandoval DC, Lin K, Pieper FP, Otter A, Kouraki A et al. ( 2022 ) . HLA‐DR polymorphism in SARS‐CoV‐2 infection and susceptibility to symptomatic COVID‐19 . Immunology vol. 166 , ( 1 ) 68 - 77 .

Baillie JK, Begg C, Clohisey Hendry S, Hinds C, Horby P, Knight J, Ling L, Maslove D et al. ( 2022 ) . Whole-genome sequencing reveals host factors underlying critical COVID-19 . Nature vol. 607 , ( 7917 ) 97 - 103 .

Wolff CB, Green DW, Paton JFR, Collier DJ ( 2022 ) . New understanding of circulatory blood flow and arterial blood pressure mechanisms . Cardiovascular Research vol. 118 , ( 4 ) e29 - e31 .

Collier D, Taylor M, Godec T, Shiel J, James R, Chowdury Y, Ebano P, Monk V et al. ( 2022 ) . Personalized electronic record supported optimisation when alone for patients with hypertension- pilot study for remote medical management of hypertension during the Covid-19 pandemic (personal covidBP) . JOURNAL OF HUMAN HYPERTENSION . vol. 36 , 8 - 8 .

Swadling L, Diniz MO, Schmidt NM, Amin OE, Chandran A, Shaw E, Pade C, Gibbons JM et al. ( 2021 ) . Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2 . Nature

Madurasinghe VW, Bower P, Eldridge S, Collier D, Graffy J, Treweek S, Knapp P, Parker A et al. ( 2021 ) . Can we achieve better recruitment by providing better information? Meta-analysis of ‘studies within a trial’ (SWATs) of optimised participant information sheets . BMC Medicine vol. 19 , ( 1 )

Niemi MEK, Karjalainen J, Liao RG, Neale BM, Daly M, Ganna A, Davis L, Lee S et al. ( 2021 ) . Mapping the human genetic architecture of COVID-19 . Nature vol. 600 , ( 7889 ) 472 - 477 .

Gupta RK, Rosenheim J, Bell LC, Chandran A, Guerra-Assuncao JA, Pollara G, Whelan M, Artico J et al. ( 2021 ) . Blood transcriptional biomarkers of acute viral infection for detection of pre-symptomatic SARS-CoV-2 infection: a nested, case-control diagnostic accuracy study . Lancet Microbe vol. 2 , ( 10 ) e508 - e517 .

Zenner D ( 2021 ) . The Barts Health NHS Trust COVID-19 cohort: characteristics, outcomes and risk scoring of patients in East London . International Journal of Tuberculosis and Lung Disease

Reynolds CJ, Pade C, Gibbons JM, Butler DK, Otter AD, Menacho K, Fontana M, Smit A et al. ( 2021 ) . Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose . Science vol. 372 , ( 6549 ) 1418 - 1423 .

Pairo-Castineira E, Clohisey S, Klaric L, Bretherick AD, Rawlik K, Pasko D, Walker S, Parkinson N et al. ( 2020 ) . Genetic mechanisms of critical illness in COVID-19 . Nature vol. 591 , ( 7848 ) 92 - 98 .

Collier DJ, Wielders P, van der Palen J, Heyes L, Midwinter D, Collison K, Preece A, Barnes N et al. ( 2020 ) . Critical Error Frequency and the Impact of Training with Inhalers Commonly used for Maintenance Treatment in Chronic Obstructive Pulmonary Disease . International Journal of Chronic Obstructive Pulmonary Disease vol. 15 , 1301 - 1313 .

Martinez FJ, Lipworth BJ, Rabe KF, Collier DJ, Ferguson GT, Sethi S, Feldman GJ, O’Brien G et al. ( 2020 ) . Benefits of glycopyrrolate/formoterol fumarate metered dose inhaler (GFF MDI) in improving lung function and reducing exacerbations in patients with moderate-to-very severe COPD: a pooled analysis of the PINNACLE studies . Respiratory Research vol. 21 , ( 1 )

CB W, DW G, JFR P, DJ C ( 2020 ) . A New Radically Improved Model of the Circulation With Important Clinical Implications . American Journal of Surgery and Clinical Case Reports ( 06 )

Souza PR, Marques RM, Gomez EA, Colas RA, De Matteis R, Zak A, Patel M, Collier DJ et al. ( 2019 ) . Enriched Marine Oil Supplements Increase Peripheral Blood Specialized Pro-Resolving Mediators Concentrations and Reprogram Host Immune Responses: A Randomized Double-Blind Placebo-Controlled Study . Circ Res

James WY, James WY, Collier D ( 2019 ) . Is electronic diary alert a false alarm in clinical studies? . Conference: General practice and primary care

Lipworth BJ, Collier DJ, Feldman GJ, Arora S, Jenkins M, Reisner C, Martin UJ ( 2019 ) . Benefits of Glycopyrrolate/Formoterol Fumarate Metered Dose Inhaler (GFF MDI) in Symptomatic Patients with COPD: A Post-Hoc Analysis from a Phase III, Randomized, Placebo-Controlled Study (PINNACLE-4) . Conference: B45. COPD: TREATMENTa3342 - a3342 .

Collier D, Wielders P, van der Palen J, Heyes L, Midwinter D, Preece A, Collison K, Barnes N et al. ( 2019 ) . Critical Error Rates with the ELLIPTA Inhaler Compared with Other Dry-Powder Inhalers in Patients with COPD: An Open-Label, Low-Intervention Clinical Study . Conference: A102. COPD: THERAPYa2437 - a2437 .

McGuire DK, Alexander JH, Johansen OE, Perkovic V, Rosenstock J, Cooper ME, Wanner C, Kahn SE et al. ( 2019 ) . Linagliptin Effects on Heart Failure and Related Outcomes in Individuals With Type 2 Diabetes Mellitus at High Cardiovascular and Renal Risk in CARMELINA . Circulation vol. 139 , ( 3 ) 351 - 361 .

Rosenstock J, Perkovic V, Johansen OE, Cooper ME, Kahn SE, Marx N, Alexander JH, Pencina M et al. ( 2019 ) . Effect of Linagliptin vs Placebo on Major Cardiovascular Events in Adults With Type 2 Diabetes and High Cardiovascular and Renal Risk: The CARMELINA Randomized Clinical Trial . JAMA vol. 321 , ( 1 ) 69 - 79 .

Collier DJ, Juhasz A, Agabiti‐Rosei E, Lloyd E, Hisada M, Zhao L, Kupfer S, Caulfield MJ ( 2018 ) . Efficacy and safety of azilsartan medoxomil/chlortalidone fixed‐dose combination in hypertensive patients uncontrolled on azilsartan medoxomil alone: A randomized trial . Journal of Clinical Hypertension vol. 20 , ( 10 ) 1473 - 1484 .

Lipworth BJ, Collier DJ, Gon Y, Zhong N, Nishi K, Chen R, Arora S, Maes A et al. ( 2018 ) . Improved lung function and patient-reported outcomes with co-suspension delivery technology glycopyrrolate/formoterol fumarate metered dose inhaler in COPD: a randomized Phase III study conducted in Asia, Europe, and the USA . Int J Chron Obstruct Pulmon Dis vol. 13 , 2969 - 2984 .

MADURASINGHE VW, Parker A, Knapp P, Treweek S, Littleford R, Gallant S, Sullivan F, Schembri S et al. ( 2018 ) . The effect of optimised patient information materials on recruitment in a lung cancer screening trial: an embedded randomised recruitment trial . Trials

Saxena M, Shour T, Shah M, Wolff CB, Julu POO, Kapil V, Collier DJ, Ng FL et al. ( 2018 ) . Attenuation of Splanchnic Autotransfusion Following Noninvasive Ultrasound Renal Denervation: A Novel Marker of Procedural Success . J Am Heart Assoc vol. 7 , ( 12 )

BROWN MJ ( 2018 ) . Investigation of the endocrine and haemodynamic changes in resistant hypertension, and its response to spironolactone or amiloride: the PATHWAY-2 mechanisms study . Lancet Diabetes and Endocrinology vol. 6 , ( 6 ) 464 - 475 .

Mukhtar O, Cheriyan J, Cockcroft JR, Collier D, Coulson JM, Dasgupta I, Faconti L, Glover M et al. ( 2018 ) . A randomized controlled crossover trial evaluating differential responses to antihypertensive drugs (used as mono- or dual therapy) on the basis of ethnicity: The comparIsoN oF Optimal Hypertension RegiMens; part of the Ancestry Informative Markers in HYpertension program—AIM-HY INFORM trial . American Heart Journal vol. 204 , 102 - 108 .

Lipworth B, Collier DJ, Gon Y, Zhong N, Nishi K, Chen R, Arora S, Maes A et al. ( 2018 ) . Glycopyrrolate/Formoterol Fumarate Fixed-Dose Combination Delivered by Metered Dose Inhaler Improves Lung Function and Symptoms in Patients with COPD: Results from the PINNACLE-4 Study in Asia, Europe, and the USA . AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE . vol. 197 ,

MacDonald TM, Williams B, Webb DJ, Morant S, Caulfield M, Cruickshank JK, Ford I, Sever P et al. ( 2017 ) . Combination Therapy Is Superior to Sequential Monotherapy for the Initial Treatment of Hypertension: A Double-Blind Randomized Controlled Trial . J Am Heart Assoc vol. 6 , ( 11 )

Al-Lamee R, Thompson D, Dehbi H-M, Sen S, Tang K, Davies J, Keeble T, Mielewczik M et al. ( 2017 ) . Percutaneous coronary intervention in stable angina (ORBITA): a double-blind, randomised controlled trial . The Lancet vol. 391 , ( 10115 ) 31 - 40 .

Saxena M, Shour T, Shah M, Wolff C, Collier DJ, Kapil V, Balawon A, Pheby JM et al. ( 2017 ) . [LB.03.06] ATTENUATION OF SPLANCHNIC AUTOTRANSFUSION FOLLOWING NON-INVASIVE ULTRASOUND RENAL DENERVATION . Journal of Hypertension . vol. 35 , e77 - e78 .

SAXENA M, Shour T, Sobotka P, Jain A, Collier DJ, Hamshere S, Mathur A, Knight C et al. ( 2017 ) . [PP.24.26] ANTIHYPERTENSIVE EFFECTS OF A CENTRAL ARTERIOVENOUS ANASTOMOSIS ARE MEDIATED THROUGH PROFOUND REDUCTION IN SYSTEMIC VASCULAR RESISTANCE . Journal of Hypertension . vol. 35 , e293 - e294 .

Ridker PM, Everett BM, Thuren T, MacFadyen JG, Chang WH, Ballantyne C, Fonseca F, Nicolau J et al. ( 2017 ) . Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease . New England Journal of Medicine vol. 377 , ( 12 ) 1119 - 1131 .

Ridker PM, Revkin J, Amarenco P, Brunell R, Curto M, Civeira F, Flather M, Glynn RJ et al. ( 2017 ) . Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients . New England Journal of Medicine vol. 376 , ( 16 ) 1527 - 1539 .

Wolff CB, Nickol AH, Collier DJ ( 2017 ) . Arterial Oxygen Saturation During Ascent to 5010 m: Heart Rate and AMS Scores . Hypoxia and Human Diseases , IntechOpen

Saxena M, Shour T, Shah M, Wolff C, Collier DJ, Kapil V, Balawon A, Pheby JM et al. ( 2017 ) . Attenuation of splanchnic autotransfusion following non-invasive ultrasound renal denervation: a novel marker of procedural success . JOURNAL OF HUMAN HYPERTENSION . vol. 31 , 679 - 680 .

Floyd CN, Adeel MY, Wolff CB, Julu P, Shah M, Collier DJ, Saxena M, Brier T et al. ( 2016 ) . First-in-man treatment of severe blood pressure variability with baroreflex activation therapy . International Journal of Cardiology vol. 220 , Article C , 577 - 579 .

Lobo MD, Adeel MY, Wolff CB, Julu PO, Shah M, Collier DM, Saxena M, Floyd C et al. ( 2016 ) . [OP.8D.02] FIRST IN MAN TREATMENT OF SEVERE BP VARIABILITY WITH BAROREFLEX ACTIVATION THERAPY . J Hypertens vol. 34 Suppl 2 , e105 - e105 .

Wolff C, Julu PO, Collier DJ, Saxena M, Kapil V, Shah M, Eftychiou S, Mills E et al. ( 2016 ) . [PP.38.09] EFFECTS OF MILD DYNAMIC EXERCISE ON CIRCULATORY AND AUTONOMIC FUNCTION IN HEALTHY VOLUNTEERS . Journal of Hypertension . vol. 34 , e351 - e352 .

Saxena M, Sobotka PA, Hamshere SM, Jain A, Mathur A, Knight C, Collier DJ, Lobo MD ( 2016 ) . Antihypertensive effects of a central arteriovenous anastomosis are mediated through profound reduction in systemic vascular resistance . Circulation: Cardiovascular Interventions vol. 9 , ( 8 )

Collier DJ, Wolff CB, Hedges A-M, Nathan J, Flower RJ, Milledge JS, Swenson ER ( 2016 ) . Benzolamide improves oxygenation and reduces acute mountain sickness during a high-altitude trek and has fewer side effects than acetazolamide at sea level . Pharmacology Research and Perspectives vol. 4 , ( 3 ) e00203 - e00203 .

Burchell AE, Chan K, Ratcliffe LEK, Hart EC, Saxena M, Collier DJ, Jain AK, Mathur A et al. ( 2016 ) . Controversies Surrounding Renal Denervation: Lessons Learned From Real‐World Experience in Two United Kingdom Centers . Journal of Clinical Hypertension vol. 18 , ( 6 ) 585 - 592 .

Madurasinghe VW, Sandra Eldridge on behalf of MRC START Group and Gordon Forbes on behalf of the START Expert Consens ( 2016 ) . Guidelines for reporting embedded recruitment trials . Trials vol. 17 , ( 1 )

Wolff CB, Collier DJ, Shah M, Saxena M, Brier TJ, Kapil V, Green D, Lobo M ( 2016 ) . A Discussion on the Regulation of Blood Flow and Pressure . vol. 876 , 129 - 135 .

Bower P, Rick J, Kennedy A, Salisbury C, Collier D, Torgerson D, Graffy J, Treweek S et al. ( 2015 ) . Testing the effectiveness of user-tested patient information on recruitment rates across multiple trials: meta-analysis of data from the start programme . Trials . vol. 16 ,

Eftychiou S, Shah M, Collier D, Julu P ( 2015 ) . Independent responses of baroreceptors and blood pressure to low bolus dose of phenylephrine in fully conscious human volunteers . Autonomic Neuroscience vol. 192 ,

Man M-S, on behalf of the Healthlines Study Group, Rick J, Bower P, on behalf of the MRC-START Group ( 2015 ) . Improving recruitment to a study of telehealth management for long-term conditions in primary care: two embedded, randomised controlled trials of optimised patient information materials . Trials vol. 16 , ( 1 )

Saxena M, Collier D, Jain A, Knight C, Mathur A, Sobotka P, Lobo M ( 2015 ) . 8C.09 . Journal of Hypertension . vol. 33 ,

Juhasz A, Collier D, Caulfield M, Agabiti-Rosei E, Huang P, Hisada M, Zhao L, Kupfer S ( 2015 ) . Achievement of Blood Pressure Targets and Safety of Azilsartan Medoxomil/Chlorthalidone Fixed Dose Combination versus Azilsartan Medoxomil in Hypertensive Patients Uncontrolled on Monotherapy . Journal of Hypertension . vol. 33 ,

Khanji M, Balawon A, Boubertakh R, Zemrak F, Collier D, Caulfield MJ, Petersen SE ( 2015 ) . LB01.07 . Journal of Hypertension . vol. 33 ,

Rull G, Mohd-Zain Z, Shiel J, Lundberg MH, Collier DJ, Johnston A, Warner TD, Corder R ( 2015 ) . Effects of High Flavanol Dark Chocolate on Cardiovascular Function and Platelet Aggregation . Vascular pharmacology

Saxena M, Collier D, Jain A, Mathur A, Knight C, Sobotka P, Lobo M ( 2015 ) . A central iliac arteriovenous anastomosis results in durable and substantial blood pressure reduction in a woman with uncontrolled hypertension and multiple antihypertensive drug intolerances . JOURNAL OF HUMAN HYPERTENSION vol. 29 , ( 10 ) 631 - 632 .

Burchell AE, Chan K, Hart EC, Saxena M, Jain AK, Collier DJ, Paton JFR, Nightingale AK et al. ( 2015 ) . Challenges facing renal denervation: insight from real world experience at two UK centres . EUROPEAN HEART JOURNAL . vol. 36 , 505 - 506 .

Lobo MD, de Belder MA, Cleveland T, Collier D, Dasgupta I, Deanfield J, Kapil V, Knight C et al. ( 2014 ) . Joint UK societies’ 2014 consensus statement on renal denervation for resistant hypertension . Heart vol. 101 , ( 1 )

Rick J, Graffy J, Knapp P, Small N, Collier DJ, Eldridge S, Kennedy A, Salisbury C et al. ( 2014 ) . Systematic techniques for assisting recruitment to trials (START): Study protocol for embedded, randomized controlled trials . Trials

Rick J, Graffy J, Knapp P, Small N, Collier DJ, Eldridge S, Kennedy A, Salisbury C et al. ( 2014 ) . Systematic techniques for assisting recruitment to trials (START): study protocol for embedded, randomized controlled trials . Trials vol. 15 , ( 1 )

Davies JE, Lacy P, Tillin T, Collier D, Cruickshank JK, Francis DP, Malaweera A, Mayet J et al. ( 2014 ) . Excess pressure integral predicts cardiovascular events independent of other risk factors in the conduit artery functional evaluation substudy of Anglo-Scandinavian Cardiac Outcomes Trial . Hypertension vol. 64 , ( 1 ) 60 - 68 .

Saxena M, Jain A, Mathur A, Knight C, Caulfield M, Collier D, Lobo M ( 2014 ) . Early reduction in blood pressure and heart rate variability following multielectrode radio-frequency renal denervation in medicines intolerant patients . JOURNAL OF HUMAN HYPERTENSION . vol. 28 , 647 - 647 .

Burchell A, Chan K, Ratcliffe L, Hart E, Saxena M, Collier D, Jain A, Mathur A et al. ( 2014 ) . Highly variable response to renal denervation for resistant hypertension - real world experience from 2 UK centres . JOURNAL OF HUMAN HYPERTENSION . vol. 28 , 645 - 646 .

Hall DP, MacCormick IJC, Phythian-Adams AT, Rzechorzek NM, Hope-Jones D, Cosens S, Jackson S, Bates MGD et al. ( 2014 ) . Network analysis reveals distinct clinical syndromes underlying acute mountain sickness . PLoS One vol. 9 , ( 1 )

Bower P, Collier D, Eldridge S, Graffy J, Kennedy A, Knapp P, Hughes-Morley A, Rick J et al. ( 2013 ) . A multimedia intervention to enhance recruitment to clinical trials in primary care and community settings: process of development and evaluation . Trials vol. 14 , ( Suppl 1 )

Rick J, Bower P, Collier D, Eldridge S, Graffy J, Kennedy A, Knapp P, Hughes-Morley A et al. ( 2013 ) . Systematic techniques for assisting recruitment to trials (START): developing the science of recruitment . Trials vol. 14 , ( Suppl 1 )

Elkhawad M, Rudd JHF, Sarov-Blat L, Cai G, Wells R, Davies LC, Collier DJ, Marber MS et al. ( 2012 ) . Effects of p38 Mitogen-Activated Protein Kinase Inhibition on Vascular and Systemic Inflammation in Patients With Atherosclerosis . JACC-CARDIOVASCULAR IMAGING vol. 5 , ( 9 ) 911 - 922 .

Wolff CB, Bell M, Thake CD, Collier DJ ( 2012 ) . Oscillations in cardiac output in hypoxia with periodic breathing and constant end-tidal PCO₂ at high altitude (5,000 m) . Adv Exp Med Biol vol. 737 , 197 - 206 .

Saxena M, Collier D, Caulfield M, Lobo M ( 2012 ) . Patients with resistant hypertension warrant a trial of salt restriction before and after renal denervation (RD) . JOURNAL OF HUMAN HYPERTENSION vol. 26 , ( 10 ) 619 - 619 .

Chan K, Ng FL, Saxena M, Collier D, Matson M, Jain A, Caulfield M, Lobo M ( 2012 ) . Renal denervation in resistant hypertension-a prospective case series . JOURNAL OF HUMAN HYPERTENSION vol. 26 , ( 10 ) 631 - 631 .

Collier DJ, Poulter NR, Dahlöf B, Sever PS, Wedel H, Buch J, Caulfield MJ, ASCOT Investigators ( 2011 ) . Impact of amlodipine-based therapy among older and younger patients in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA) . J Hypertens vol. 29 , ( 3 ) 583 - 591 .

Collier DJ, Poulter NR, Dahlöf B, Sever PS, Wedel H, Buch J, Caulfield MJ, ASCOT Investigators ( 2011 ) . Impact of atorvastatin among older and younger patients in the Anglo-Scandinavian Cardiac Outcomes Trial Lipid-Lowering Arm . J Hypertens vol. 29 , ( 3 ) 592 - 599 .

Cheriyan J, Webb AJ, Sarov-Blat L, Elkhawad M, Wallace SML, Maki-Petaja KM, Collier DJ, Morgan J et al. ( 2011 ) . Inhibition of p38 Mitogen-Activated Protein Kinase Improves Nitric Oxide-Mediated Vasodilatation and Reduces Inflammation in Hypercholesterolemia . CIRCULATION vol. 123 , ( 5 ) 515 - 523 .

Cascade E, Collier D, Kula-Przezwanski C ( 2011 ) . IMPROVING PATIENT SAFETY IN THE UK AND ENGAGING PATIENTS IN RESEARCH: A NEW MODEL FOR THE NHS? . VALUE IN HEALTH vol. 14 , ( 7 ) A333 - A333 .

Gupta A, Chang CL, Collier D, Dahlof B, Poulter NR, Sever PS ( 2011 ) . THE RELATIONSHIP BETWEEN STATIN THERAPY AND PROGRESSION OF RENAL DAMAGE AMONG 10305 HYPERTENSIVE PATIENTS RANDOMISED IN THE ASCOT-LIPID-LOWERING ARM (LLA) . ATHEROSCLEROSIS SUPPLEMENTS . vol. 12 , 158 - 159 .

Chik Z, Tucker AT, Shiel JI, Collier DJ, Perrett D, Lee TD, Johnston A ( 2010 ) . Comparative Pharmacokinetic Assessments of Topical Drugs: Evaluation by Dermatopharmacokinetics, Microdialysis, and Systemic Measurement . J INVEST DERMATOL vol. 130 , ( 12 ) 2828 - 2830 .

Collier DJ, Robson J, Scott R, Will CM, Eldridge SE, Griffiths CJ, Badrick E, Saxena M et al. ( 2010 ) . HiLo: a health services intervention study: methods and interim results on the first 2000 patients at 1 year . J HUM HYPERTENS vol. 24 , ( 10 ) 708 - 709 .

Gupta AK, Poulter NR, Dobson J, Eldridge S, Cappuccio FP, Caulfield M, Collier D, Cruickshank JK et al. ( 2010 ) . Ethnic Differences in Blood Pressure Response to First and Second-Line Antihypertensive Therapies in Patients Randomized in the ASCOT Trial . AM J HYPERTENS vol. 23 , ( 9 ) 1023 - 1030 .

Davies JE, Lacy PS, Cruickshank K, Stanton A, Collier D, Thurston H, Williams B, Parker KH et al. ( 2010 ) . Excess pressure is higher in atenolol-treated individuals and independently predicts cardiovascular events in the CAFE substudy of ASCOT . EUROPEAN HEART JOURNAL . vol. 31 , 902 - 902 .

Dolan E, Caulfield M, Thom S, McInnes G, Collier D, O'Brien E, Stanton A ( 2010 ) . AMBULATORY ARTERIAL STIFFNESS INDEX PREDICTS CARDIOVASCULAR MORBIDITY AND MORTALITY IN TREATED HYPERTENSIVE PATIENTS - AN ANGLO - SCANDINAVIAN CARDIAC OUTCOME TRIAL SUB-STUDY . JOURNAL OF HYPERTENSION . vol. 28 , E13 - E14 .

Davies J, Tillin T, Malaweera A, Lacy P, Cruickshank K, Stanton A, Collier D, Thurston H et al. ( 2010 ) . EXCESS PRESSURE IS HIGHER IN ATENOLOL-TREATED INDIVIDUALS AND INDEPENDENTLY PREDICTS CARDIOVASCULAR EVENTS IN THE CAFE SUBSTUDY OF ASCOT: HT.2.03 . Journal of Hypertension vol. 28 ,

Graffy J, Bower P, Ward E, Wallace P, Delaney B, Kinmonth AL, Collier D, Miller J ( 2010 ) . Trials within trials? Researcher, funder and ethical perspectives on the practicality and acceptability of nesting trials of recruitment methods in existing primary care trials . BMC MED RES METHODOL vol. 10 , Article 38 ,

Elkhawad M, Rudd JH, Sarov-Blat L, Marber M, Choudhury RP, Davies LC, Collier DJ, Cai G et al. ( 2010 ) . Inhibition of p38 Mitogen-Activated Protein Kinase Attenuates Vascular and Systemic Inflammation in Patients with Atherosclerosis as Assessed by 18-F Fluorodeoxyglucose PET-CT . CIRCULATION vol. 122 , ( 21 )

Davies JE, Tillin T, Malaweera A, Lacy PS, Cruickshank K, Stanton A, Collier D, Thurston H et al. ( 2010 ) . Pressure-Independent Pulsatility Index (PIPI) Independently Predicts Cardiovascular Events in the Cafe Sub-Study of Ascot . CIRCULATION vol. 122 , ( 21 )

Davies JE, Malaweera A, Lacy PS, Cruickshank K, Stanton A, Collier D, Thurston H, Williams B et al. ( 2010 ) . Wave Pressure is Higher in Atenolol-treated Individuals and Independently Predicts Cardiovascular Events in the Cafe Substudy of ASCOT . Artery Research vol. 4 , ( 4 )

Dolan E, Stanton AV, Thom S, Caulfield M, Atkins N, McInnes G, Collier D, Dicker P et al. ( 2009 ) . Ambulatory blood pressure monitoring predicts cardiovascular events in treated hypertensive patients - an Anglo-Scandinavian cardiac outcomes trial substudy . J HYPERTENS vol. 27 , ( 4 ) 876 - 885 .

Collier DJ, Stride TJ, He S, Wilson SL, Shiel JI, Caulfield MJ ( 2009 ) . Impact of Lifestyle Changes During Five Years of Drug Treatment in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) . JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY . vol. 53 , A215 - A215 .

Williams B, Lacy PS, Cruickshank JK, Collier D, Hughes AD, Stanton A, Thom S, Thurston H et al. ( 2009 ) . Impact of Statin Therapy on Central Aortic Pressures and Hemodynamics Principal Results of the Conduit Artery Function Evaluation-Lipid-Lowering Arm (CAFE-LLA) Study . CIRCULATION vol. 119 , ( 1 ) 53 - U98 .

Hawa MI, Thivolet C, Mauricio D, Alemanno I, Cipponeri E, Collier D, Hunter S, Buzzetti R et al. ( 2008 ) . Metabolic Syndrome and Autoimmune Diabetes: Action LADA 3 . Diabetes Care vol. 32 , ( 1 ) 160 - 164 .

Hawa MI, Cipponeri E, Collier D, Loh Y, Pozzilli P, Brophy S, Hunter S, Thivolet C et al. ( 2008 ) . The prevalence of metabolic syndrome is much less in LADA and type 1 diabetes than type 2 diabetes: ACTION LADA 3 . DIABETOLOGIA vol. 51 , S155 - S155 .

Collier DJ, Nickol AH, Milledge JS, van Ruiten HJA, Collier CJ, Swenson ER, Datta A, Wolff CB ( 2008 ) . Alveolar PCO2 oscillations and ventilation at sea level and at high altitude . J Appl Physiol (1985) vol. 104 , ( 2 ) 404 - 415 .

Mytton OT, Simpson A, Thompson AAR, Oram RA, Darowski A, Yu L-M, Collier DJ, Pollard AJ ( 2008 ) . Manual assessment of the initial fall in blood pressure after orthostatic challenge at high altitude . Wilderness Environ Med vol. 19 , ( 4 ) 225 - 232 .

Collier DJ, Davies LC, Bernardi L, Sleight P, Misra S, Shiel J, David CM, Scott B et al. ( 2007 ) . Baroreceptor function changes with differing blood pressure treatment during the anglo-scandinavian cardiac outcomes trial: principal results from the cardiac autonomic reflex assessment trial (CARAT) . J HUM HYPERTENS vol. 21 , ( 10 ) 846 - 847 .

Collier D, Davies L, Bernardi L, Sleight P, Shiel J, Patel N, Misra S, Martin T et al. ( 2007 ) . Baroreceptor function changes with differing blood pressure treatment during the Anglo-Scandinavian Cardiac Outcomes Trial: Principal results from the Cardiac Autonomic Reflex Assessment Trial (CARAT) . JOURNAL OF HYPERTENSION . vol. 25 , S292 - S292 .

Chik Z, Tucker AT, Shiel JI, Collier DJ, Perrett D, Lee TD, Johnston A ( 2007 ) . Comparative pharmacokinetic assessments of topically applied drugs: evaluation by dermatopharmacokinetic, microdialysis and systemic measurement . BRITISH JOURNAL OF CLINICAL PHARMACOLOGY . vol. 63 , 775 - 776 .

Collier D, Arunachalam G, Johnston A, Richards S, Shiel J, Wells Z, David C, Caulfield M ( 2007 ) . Continuing reduction of microalbuminuria and proteinuria during follow-up for the Anglo-Scandinavian Cardiac Outcomes Trial dominance of duration and blood pressure over other effects . JOURNAL OF HYPERTENSION . vol. 25 , S150 - S150 .

Wolff CB, Thake CD, Truesdell A, Mattison D, Handcock L, Collier DJ, Milledge JS ( 2007 ) . Oxygen delivery at sea level and altitude (after slow ascent to 5000 meters), at rest and in mild exercise . Adv Exp Med Biol . vol. 599 , 191 - 197 .

Nickol AH, Leverment J, Richards P, Seal P, Harris GA, Cleland J, Dubowitz G, Collier DJ et al. ( 2006 ) . Temazepam at high altitude reduces periodic breathing without impairing next-day performance: a randomized cross-over double-blind study . J Sleep Res vol. 15 , ( 4 ) 445 - 454 .

Collier DJ, Caulfield MJ, Poulter NR, Dahlof B, Wedel H, Sever PS ( 2006 ) . Did older or younger patients benefit more from amlodipine based vs atenolol based therapy in ASCOT-BPLA? . CIRCULATION . vol. 114 , 896 - 896 .

Williams B, Lacy PS, Thurston H, Thom S, Hughes A, Cruickshank K, Stanton A, Collier D et al. ( 2006 ) . Response to letters regarding article, "differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: Principal results of the Conduit Artery Function Evaluation (CAFE) Study" . CIRCULATION vol. 114 , ( 15 ) E540 - E541 .

Williams B, Lacy PS, Thom SM, Cruickshank K, Stanton A, Collier D, Hughes AD, Thurston H et al. ( 2006 ) . Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes - Principal results of the Conduit Artery Function Evaluation (CAFE) study . CIRCULATION vol. 113 , ( 9 ) 1213 - 1225 .

Poulter NR, Dahlof B, Sever PS, Wedel H, Collier D ( 2006 ) . Impact of atorvastatin on cardiovascular events in 2440 men and women aged 65 years and above: Evidence from the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA) . STROKE . vol. 37 , 695 - 695 .

Dahlof B, Sever PS, Poulter NR, Wedel H, Beevers DG, Caulfield M, Collins R, Kjeldsen SE et al. ( 2005 ) . Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial . LANCET vol. 366 , ( 9489 ) 895 - 906 .

Sever PS, Poulter NR, Dahlöf B, Wedel H, Anglo-Scandinavian Cardiac Outcomes Trial Investigators ( 2005 ) . Different time course for prevention of coronary and stroke events by atorvastatin in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid-Lowering Arm (ASCOT-LLA) . Am J Cardiol vol. 96 , ( 5A ) 39F - 44F .

Lindgren P, Buxton M, Kahan T, Poulter NR, Dahlöf B, Sever PS, Wedel H, Jönsson B et al. ( 2005 ) . Cost-effectiveness of atorvastatin for the prevention of coronary and stroke events: an economic analysis of the Anglo-Scandinavian Cardiac Outcomes Trial--lipid-lowering arm (ASCOT-LLA) . Eur J Cardiovasc Prev Rehabil vol. 12 , ( 1 ) 29 - 36 .

Wolff CB, Checkley SK, Bhageerutty G, Bhatt H, Johnston A, Collier DJ, Tachtsidis I, Garvie N et al. ( 2005 ) . Circulation time in man from lung to periphery as an indirect index of cardiac output . Adv Exp Med Biol . vol. 566 , 311 - 316 .

COLLIER DJ, Caulfield M, Kristinsson A, Kjeldsen SE, Dahlof B, Sever PS, Poulter NR, Wedel H et al. ( 2005 ) . Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac OutcomesTrial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial . Lancet vol. 10366 , ( 9489 ) 895 - 906 .

Kaimal S, Collier DJ, Myers SL, Rhodus NL ( 2004 ) . Understanding and managing fetal alcohol syndrome . Northwest Dent vol. 83 , ( 1 ) 13 - passim .

Wilson S, Johnston A, Robson J, Poulter N, Collier D, Feder G, Caulfield MJ ( 2003 ) . Comparison of methods to identify individuals at increased risk of coronary disease from the general population . BMJ vol. 326 , ( 7404 )

Silber E, Sonnenberg P, Collier DJ, Pollard AJ, Murdoch DR, Goadsby PJ ( 2003 ) . Clinical features of headache at altitude: a prospective study . Neurology vol. 60 , ( 7 ) 1167 - 1171 .

Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE et al. ( 2003 ) . Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial . LANCET vol. 361 , ( 9364 ) 1149 - 1158 .

Jorga A, Collier D, Priston B, Clavel D, Johnston A ( 2003 ) . Adults' reactions to inhaled denatonium benzoate (Bitrex (R)) . BRITISH JOURNAL OF CLINICAL PHARMACOLOGY . vol. 55 , 447 - 447 .

Wilson S, Johnston A, Collier DJ, Caulfield M ( 2003 ) . Feasibility of enrolling patients to hypertension outcome trials based on an assessment of their cardiovascular risk . BRITISH JOURNAL OF CLINICAL PHARMACOLOGY . vol. 55 , 425 - 426 .

Wilson S, Johnston A, Robson J, Poulter NR, Collier DJ, Feder GS, Caulfield MJ ( 2003 ) . Predicting coronary risk in the general population--is it necessary to measure high-density lipoprotein cholesterol? . J Cardiovasc Risk vol. 10 , ( 2 ) 137 - 141 .

COLLIER DJ, Caulfield M, Kristinsson A, Beevers G, Wedel H, Collins R, Kjeldsen SE, Poulter NR et al. ( 2003 ) . Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial . Lancet vol. 361 , ( 9364 ) 1149 - 1158 .

Bailey DM, Davies B, Castell LM, Collier DJ, Milledge JS, Hullin DA, Seddon PS, Young IS ( 2003 ) . Symptoms of infection and acute mountain sickness; associated metabolic sequelae and problems in differential diagnosis . High Alt Med Biol vol. 4 , ( 3 ) 319 - 331 .

Wolff CB, Checkley SK, Bhageerutty G, Bhatt H, Johnston A, Collier DJ, Garvie N, Rosenberg ME et al. ( 2002 ) . Circulation time in man from lung to periphery - pulse and non-pulse oximetry . JOURNAL OF PHYSIOLOGY-LONDON . vol. 543 , 41P - 41P .

Woods DR, Pollard AJ, Collier DJ, Jamshidi Y, Vassiliou V, Hawe E, Humphries SE, Montgomery HE ( 2002 ) . Insertion/deletion polymorphism of the angiotensin I-converting enzyme gene and arterial oxygen saturation at high altitude . Am J Respir Crit Care Med vol. 166 , ( 3 ) 362 - 366 .

Wilson S, Johnston A, Robson J, Poulter N, Collier D, Feder G, Caulfield M ( 2002 ) . Should we measure high density lipoprotein cholesterol in people with hypertension? . JOURNAL OF HYPERTENSION . vol. 20 , S150 - S150 .

Wolff CB, Barry P, Collier DJ ( 2002 ) . Cardiovascular and respiratory adjustments at altitude sustain cerebral oxygen delivery -- Severinghaus revisited . Comp Biochem Physiol A Mol Integr Physiol . vol. 132 , 221 - 229 .

Wilson CM, Bakewell SE, Miller MR, Hart ND, McMorrow RCN, Barry PW, Collier DJ, Watt SJ et al. ( 2002 ) . Increased resting bronchial tone in normal subjects acclimatised to altitude . Thorax vol. 57 , ( 5 ) 400 - 404 .

Wilson S, Johnston A, Robson J, Poulter N, Collier D, Feder G, Caulfield M ( 2002 ) . OR-4: Who should have their cholesterol measured? A comparison of selective cholesterol screening methods . American Journal of Hypertension vol. 15 , ( S3 ) 2a - 2a .

Collier DJ, Martin TA, Angell-James JE, Bernardi L, Sleight P, Caulfield MJ ( 2002 ) . P-334: Gender differences in carotid sinus baroreceptor reflexes in healthy young normal subjects and in ASCOT patients with treated essential hypertension . American Journal of Hypertension vol. 15 , ( S3 ) 151a - 151a .

Woods DR, Pollard AJ, Collier DJ, Jones A, Everest A, Jamshidi Y, Vassiliou V, Hawe E et al. ( 2001 ) . Increased arterial oxygen saturation conferred by the I allele of the angiotensin I-converting enzyme gene at high altitude . CIRCULATION vol. 104 , ( 17 ) 447 - 447 .

Collier DJ, Bernardi L, Angell-James JE, Caulfield MJ, Sleight P, Anglo-Scandinavian Cardiac Outcomes Trial ( 2001 ) . Baroreflex sensitivity and heart rate variability as predictors of cardiovascular outcome in hypertensive patients with multiple risk factors for coronary disease . J Hum Hypertens vol. 15 Suppl 1 , S57 - S60 .

Kirby PL, Caulfield MC, Collier DJ, Eldridge S, Griffiths CG, Hemingway H, Poulter NR, Feder GS et al. ( 2001 ) . Differential response to amlodipine and atenolol mono-therapy for hypertension by ethnic group . J Hum Hypertens vol. 15 Suppl 1 , S61 - S64 .

Wilson S, Collier D, Johnston A, Poulter N, Feder G, Robson J, Caulfield M, Anglo-Scandinavian Cardiac Outcomes Trial ( 2001 ) . Evaluation of cardiovascular risk equations using the ASCOT cohort . J Hum Hypertens vol. 15 Suppl 1 , S31 - S33 .

Mason NP, Barry PW, Pollard AJ, Collier DJ, Taub NA, Miller MR, Milledge JS ( 2000 ) . Serial changes in spirometry during an ascent to 5,300 m in the Nepalese Himalayas . High Altitude Medicine & Biology vol. 1 , ( 3 ) 185 - 195 .

Nickol A, Collier D ( 1999 ) . Kangchenjunga 1998 . Hypoxia , vol. 474 , Springer Nature

Caulfield M, Collier D, O'Byrne S ( 1998 ) . The genetic basis of hypertension: progress and opportunities . British Journal of Hospital Medicine vol. 59 , ( 1 ) 37 - 40 .

Pollard AJ, Collier D, Mason NP, Barry PW ( 1997 ) . Changes in lung function on ascent to altitude . Thorax vol. 52 , ( SUPPL. 6 )

Pollard AJ, Barry PW, Mason NP, Collier DJ, Pollard RC, Pollard PFA, Martin I, Fraser RS et al. ( 1997 ) . Hypoxia, Hypocapnia and Spirometry at Altitude . Clinical Science vol. 92 , ( 6 ) 593 - 598 .

Pollard AJ, Mason NP, Barry PW, Pollard RC, Collier DJ, Fraser RS, Miller MR, Milledge JS ( 1996 ) . Effect of altitude on spirometric parameters and the performance of peak flow meters . Thorax vol. 51 , ( 2 )

Barry PW, Mason NP, Collier D ( 1995 ) . Mount Everest study supports use of capillary samples . The BMJ vol. 310 , ( 6986 )

Collier D, Angell-James J ( 1991 ) . 9 On the location of the defect in the carotid sinus baroreceptor reflex arc in human essential hypertension . Journal of Hypertension vol. 9 , ( 11 )

Angell-James JE, Collier DJ ( 1991 ) . Modification of Carotid Baroreflex by Trigeminal Stimulation in Hypertensive Man . Clinical Science vol. 80 , ( s24 ) 14p - 15p .

Angell-James JE, Besser GM, Bouloux P, Collier DJ, Grossman A, McMurray RG ( 1990 ) . Naloxone infusion and carotid sinus baroreceptor reflex in resting man . Journal of Physiology . vol. 427 ,

Collier DJ, Beales IL ( 1989 ) . Drinking among medical students: a questionnaire survey . BMJ vol. 299 , ( 6690 ) 19 - 22 .

Angell-James JE, Collier DJ, de Daly MB ( 1987 ) . Effects of Trigeminal Receptor Stimulation on the Baroreceptor Reflex Control of Heart Rate in Normal Man . Clinical Science vol. 73 , ( s17 ) 48p - 48p .