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Publications:  Dr Pedro Rodriguez Cutillas

Wong PP, Muñoz-Félix JM, Hijazi M, Kim H, Robinson SD, De Luxán-Delgado B, Rodríguez-Hernández I, Maiques O et al.(2020). Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk with Tumor Cells. Cell vol. 181, (6) 1346-1363.e21.
Invergo BM, Petursson B, Akhtar N, Bradley D, Giudice G, Hijazi M, Cutillas P, Petsalaki E et al.(2020). Prediction of Signed Protein Kinase Regulatory Circuits. Cell Systems vol. 10, (5) 384-396.e9.
Demircioglu F, Wang J, Candido J, Costa ASH, Casado P, de Luxan Delgado B, Reynolds LE, Gomez-Escudero J et al.(2020). Cancer associated fibroblast FAK regulates malignant cell metabolism. Nature Communications vol. 11, (1) 1290-1290.
Huang KW, Reebye V, Czysz K, Ciriello S, Dorman S, Reccia I, Lai HS, Peng L et al.(2020). Liver Activation of Hepatocellular Nuclear Factor-4α by Small Activating RNA Rescues Dyslipidemia and Improves Metabolic Profile. Molecular Therapy - Nucleic Acids vol. 19, 361-370.
Hijazi M, Smith R, Rajeeve V, Bessant C, Cutillas PR(2020). Reconstructing kinase network topologies from phosphoproteomics data reveals cancer-associated rewiring. Nature Biotechnology
Kostaras E, Kaserer T, Lazaro G, Heuss SF, Hussain A, Casado P, Hayes A, Yandim C et al.(2020). A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity. British Journal of Cancer
Cutillas PR, Hijazi M, Smith R, Bessant C, Britton D (2019). Chemical phosphoproteomics systematically identifies circuitries of kinase networks in cancer cells and predicts their response to kinase inhibitors. MOLECULAR CANCER THERAPEUTICS. vol. 18,
Martín-Guerrero SM, Casado P, Muñoz-Gámez JA, Carrasco M-C, Navascués J, Cuadros MA, López-Giménez JF, Cutillas PR et al.(2019). Poly(ADP-Ribose) Polymerase-1 inhibition potentiates cell death and phosphorylation of DNA damage response proteins in oxidative stressed retinal cells. Exp Eye Res vol. 188,
Thomas JR, Moore KM, Sproat C, Mo S, Wolanska KI, Maldonado H, Haider S, Newman D et al. (2019). Integrin alpha V beta 6-EGFR crosstalk regulates bidirectional force transmission and controls breast cancer invasion. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 100, A39-A39.
Alrawashdeh W, Jones R, Dumartin L, Radon TP, Cutillas PR, Feakins RM, Dmitrovic B, Demir IE et al.(2019). Perineural invasion in pancreatic cancer: proteomic analysis and in vitro modelling. Mol Oncol vol. 13, (5) 1075-1091.
Kostelnik KB, Barker A, Schultz C, Mitchell TP, Rajeeve V, White IJ, Aurrand-Lions M, Nourshargh S et al.(2019). Dynamic trafficking and turnover of JAM-C is essential for endothelial cell migration. PLoS Biology vol. 17, (12)
Arnandis T, Monteiro P, Adams SD, Bridgeman VL, Rajeeve V, Gadaleta E, Marzec J, Chelala C et al.(2018). Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion. Developmental Cell vol. 47, (4) 409-424.e9.
Angulo-Urarte A, Casado P, Castillo SD, Kobialka P, Kotini MP, Figueiredo AM, Castel P, Rajeeve V et al.(2018). Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility. Nat Commun vol. 9, (1)
Simon T, Pinioti S, Schellenberger P, Rajeeve V, Wendler F, Cutillas PR, King A, Stebbing J et al.(2018). Shedding of bevacizumab in tumour cells-derived extracellular vesicles as a new therapeutic escape mechanism in glioblastoma. Mol Cancer vol. 17, (1)
Casado P, Wilkes EH, Miraki-Moud F, Hadi MM, Rio-Machin A, Rajeeve V, Pike R, Iqbal S et al.(2018). Proteomic and genomic integration identifies kinase and differentiation determinants of kinase inhibitor sensitivity in leukemia cells. Leukemia vol. 32, (8) 1818-1822.
Tummala H, Dokal AD, Walne A, Ellison A, Cardoso S, Amirthasigamanipillai S, Kirwan M, Browne I et al.(2018). Genome instability is a consequence of transcription deficiency in patients with bone marrow failure harboring biallelic ERCC6L2 variants. Proc Natl Acad Sci U S A vol. 115, (30) 7777-7782.
Fearon AE, Carter EP, Clayton NS, Wilkes EH, Baker AM, Kapitonova E, Bakhouche BA, Tanner Y et al.(2018). PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer. Cell Reports vol. 22, (9) 2469-2481.
Casado P, Wilkes EH, Miraki-Moud F, Hadi MM, Rio-Machin A, Rajeeve V, Pike R, Iqbal S et al.(2017). Proteomic and genomic integration identifies kinase and differentiation determinants of kinase inhibitor sensitivity in leukemia cells. Leukemia
Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D et al.(2017). Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers. Cancer Discov
Dermit M, Dokal A, Cutillas PR(2017). Approaches to identify kinase dependencies in cancer signalling networks. FEBS Lett vol. 591, (17) 2577-2592.
Wilkes EH, Casado P, Rajeeve V, Cutillas PR(2017). Kinase activity ranking using phosphoproteomics data (KARP) quantifies the contribution of protein kinases to the regulation of cell viability. Mol Cell Proteomics vol. 16, (9) 1694-1704.
Naba A, Pearce OMT, Del Rosario A, Ma D, Ding H, Rajeeve V, Cutillas PR, Balkwill FR et al.(2017). Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. Journal of Proteome Research vol. 16, (8) 3083-3091.
Cutillas PR (2017). Systems Biology of Oncogenic Signaling. MOLECULAR & CELLULAR PROTEOMICS. vol. 16, S15-S15.
Wilkes E, Cutillas PR(2017). Label-Free Phosphoproteomic Approach for Kinase Signaling Analysis. Methods Mol Biol vol. 1636, 199-217.
Yuzugulen J, Douthwaite JA, Wood EG, Villar IC, Patel NSA, Jegard J, Gaertner H, Rossitto-Borlat I et al.(2017). Characterisation of preproendothelin-1 derived peptides identifies Endothelin-Like Domain Peptide as a modulator of Endothelin-1. Sci Rep vol. 7, (1) 4956-4956.
Fernandez-Varo G, Oro D, Yudina T, Carvajal S, Marfa S, Boix L, Perramon M, Oller L et al. (2017). Cerium oxide nanoparticles display anti-tumoral activity and improve survival in experimental hepatocellular carcinoma. JOURNAL OF HEPATOLOGY. Conference: The International Liver Congress™ EASL 2017 - European Association for the Study of the Live (Amsterdam, Holland) from: 19/04/2017 to: 23/04/2017, vol. 66, S229-S230.
Cutillas PR(2017). Targeted In-Depth Quantification of Signaling Using Label-Free Mass Spectrometry. Methods Enzymol vol. 585, 245-268.
Graupera M, Angulo-Urarte A, Kobialka P, Castel P, Casado PM, Affolter M, Gerhardt H, Belting H-G et al. (2017). The p110alpha/PI3K controls endothelial cell rearrangements during angiogenesis by stimulating MLC2 dephosphorylation. JOURNAL OF VASCULAR RESEARCH. vol. 54, 73-73.
Dermit M, Casado P, Rajeeve V, Wilkes EH, Foxler DE, Campbell H, Critchlow S, Sharp TV et al.(2016). Oxidative stress downstream of mTORC1 but not AKT causes a proliferative defect in cancer cells resistant to PI3K inhibition. Oncogene
Afzal TA, Luong LA, Chen D, Zhang C, Yang F, Chen Q, An W, Wilkes E et al.(2016). NCK Associated Protein 1 Modulated by miRNA-214 Determines Vascular Smooth Muscle Cell Migration, Proliferation, and Neointima Hyperplasia. Journal of the American Heart Association vol. 5, (12) e004629-e004629.
Casado P, Wilkes E, Hadi MM, Rajeeve V, Miraki-Moud F, Pike R, Del Rio-Machin A, Iqbal S et al. (2016). Differentiation Status Revealed By Shotgun Phosphoproteomics Determines Sensitivity of Primary AML Cells to Kinase Inhibitors. BLOOD. vol. 128,
Britton DJ, Wilkes E, Casado P, Rajeeve V, Fitzgibbon J, Gribben J, Cutillas PR (2016). Proteomic Analysis Directs Effective Drug Selection in Relapsed AML By Quantifying Drug Targets. BLOOD. vol. 128,
Villoria MT, Ramos F, Dueñas E, Faull P, Cutillas PR, Clemente-Blanco A(2016). Stabilization of the metaphase spindle by Cdc14 is required for recombinational DNA repair. EMBO J vol. 36, (1) 79-101.
Prysyazhna O, Scotcher J, Boguslavskyi A, Kistamas K, Hadgraft N, Martin ED, Worthington J, Rudyk O et al. (2016). Redox Control of Protein Kinase G I alpha Fine-Tunes the Frank-Starling Law of the Heart in Vivo by Regulating Diastolic Relaxation. FREE RADICAL BIOLOGY AND MEDICINE. vol. 100, S148-S148.
Scotcher J, Prysyazhna O, Boguslavskyi A, Kistamas K, Hadgraft N, Martin ED, Worthington J, Rudyk O et al.(2016). Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank-Starling response. Nature Communications vol. 7, 13187-13187.
Casado P, Hijazi M, Britton D, Cutillas PR(2016). Impact of phosphoproteomics in the translation of kinase targeted therapies. Proteomics
Sciacovelli M, Gonçalves E, Johnson TI, Zecchini VR, da Costa ASH, Gaude E, Drubbel AV, Theobald SJ et al.(2016). Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition. Nature vol. 537, (7621) 544-547.
Montfort A, Pearce OMT, Maniati E, Vincent B, Bixby LM, Bo hm S, Dowe T, Wilkes EH et al.(2016). A strong B cell response is part of the immune landscape in human high-grade serous ovarian metastases. Clinical Cancer Research
Kulbe H, Iorio F, Chakravarty P, Milagre CS, Moore R, Thompson RG, Everitt G, Canosa M et al.(2016). Integrated transcriptomic and proteomic analysis identifies protein kinase CK2 as a key signaling node in an inflammatory cytokine network in ovarian cancer cells. Oncotarget vol. 7, (13) 15648-15661.
Quétier I, Marshall JJT, Spencer-Dene B, Lachmann S, Casamassima A, Franco C, Escuin S, Worrall JT et al.(2016). Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion. Cell Reports vol. 14, (3) 440-448.
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Arozena AA, Adachi H, Adams CM et al.(2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy vol. 12, (1) 1-222.
Cutillas PR, Crnogorac-Jurcevic T(2016). Application of Proteomics in Cancer Biomarker Discovery: GeLC-MS/MS. Methods Mol Biol vol. 1381, 201-209.
Arnandis T, Rajeeve V, Brennan CH, Cutillas PR, Godinho SA (2016). Paracrine-mediated invasion induced by centrosome amplification. MOLECULAR BIOLOGY OF THE CELL. vol. 27,
Terfve CDA, Wilkes EH, Casado P, Cutillas PR, Saez-Rodriguez J(2015). Large-scale models of signal propagation in human cells derived from discovery phosphoproteomic data. Nat Commun vol. 6,
Carretero L, Llavona P, López-Hernández A, Casado P, Cutillas PR, de la Peña P, Barros F, Domínguez P(2015). ERK and RSK are necessary for TRH-induced inhibition of r-ERG potassium currents in rat pituitary GH3 cells. Cell Signal vol. 27, (9) 1720-1730.
Wilkes EH, Terfve C, Gribben JG, Saez-Rodriguez J, Cutillas PR(2015). Empirical inference of circuitry and plasticity in a kinase signaling network. Proc Natl Acad Sci U S A vol. 112, (25) 7719-7724.
Cutillas PR(2015). Role of phosphoproteomics in the development of personalized cancer therapies. Proteomics Clin Appl vol. 9, (3-4) 383-395.
Rotival M, Ko J-H, Srivastava PK, Kerloc'h A, Montoya A, Mauro C, Faull P, Cutillas PR et al.(2015). Integrating phosphoproteome and transcriptome reveals new determinants of macrophage multinucleation. Mol Cell Proteomics vol. 14, (3) 484-498.
Hall AM, Vilasi A, Garcia-Perez I, Lapsley M, Alston CL, Pitceathly RDS, McFarland R, Schaefer AM et al.(2015). The urinary proteome and metabonome differ from normal in adults with mitochondrial disease. Kidney Int vol. 87, (3) 610-622.
Wilkes EH, Casado P, Cutillas PR(2014). Approaches for measuring signalling plasticity in the context of resistance to targeted cancer therapies. Biochem Soc Trans vol. 42, (4) 791-797.
Rajeeve V, Vendrell I, Wilkes E, Torbett N, Cutillas PR(2014). Cross-species proteomics reveals specific modulation of signaling in cancer and stromal cells by phosphoinositide 3-kinase (PI3K) inhibitors. Mol Cell Proteomics vol. 13, (6) 1457-1470.
Casado P, Bilanges B, Rajeeve V, Vanhaesebroeck B, Cutillas PR(2014). Environmental Stress Affects the Activity of Metabolic and Growth Factor Signaling Networks and Induces Autophagy Markers in MCF7 Breast Cancer Cells. MOLECULAR & CELLULAR PROTEOMICS vol. 13, (3) 836-848.
Casado P, Alcolea MP, Iorio F, Rodríguez-Prados J-C, Vanhaesebroeck B, Saez-Rodriguez J, Joel S, Cutillas PR(2013). Phosphoproteomics data classify hematological cancer cell lines according to tumor type and sensitivity to kinase inhibitors. Genome Biol vol. 14, (4)
Casado P, Rodriguez-Prados J-C, Cosulich SC, Guichard S, Vanhaesebroeck B, Joel S, Cutillas PR(2013). Kinase-substrate enrichment analysis provides insights into the heterogeneity of signaling pathway activation in leukemia cells. Sci Signal vol. 6, (268)
Rajeeve V, Pearce W, Cascante M, Vanhaesebroeck B, Cutillas PR(2013). Polyamine production is downstream and upstream of oncogenic PI3K signalling and contributes to tumour cell growth. Biochem J vol. 450, (3) 619-628.
Beltran L, Casado P, Rodríguez-Prados J-C, Cutillas PR(2012). Global profiling of protein kinase activities in cancer cells by mass spectrometry. J Proteomics vol. 77, 492-503.
Beltran L, Cutillas PR(2012). Advances in phosphopeptide enrichment techniques for phosphoproteomics. Amino Acids vol. 43, (3) 1009-1024.
Cappadona S, Baker PR, Cutillas PR, Heck AJR, van Breukelen B(2012). Current challenges in software solutions for mass spectrometry-based quantitative proteomics. AMINO ACIDS vol. 43, (3) 1087-1108.
Alcolea MP, Casado P, Rodríguez-Prados J-C, Vanhaesebroeck B, Cutillas PR(2012). Phosphoproteomic analysis of leukemia cells under basal and drug-treated conditions identifies markers of kinase pathway activation and mechanisms of resistance. Mol Cell Proteomics vol. 11, (8) 453-466.
Burling KA, Cutillas PR, Church D, Lapsley M, Norden AGW(2012). Analysis of molecular forms of urine Retinol-Binding Protein in Fanconi Syndrome and design of an accurate immunoassay. CLINICA CHIMICA ACTA vol. 413, (3-4) 483-489.
Worthington J, Cutillas PR, Timms JF(2011). IMAC/TiO2 enrich for peptide modifications other than phosphorylation: Implications for chromatographic choice and database searching in phosphoproteomics. PROTEOMICS vol. 11, (23) 4583-4587.
Beltran L, Chaussade C, Vanhaesebroeck B, Cutillas PR(2011). Calpain interacts with class IA phosphoinositide 3-kinases regulating their stability and signaling activity. Proc Natl Acad Sci U S A vol. 108, (39) 16217-16222.
Montoya A, Beltran L, Casado P, Rodríguez-Prados J-C, Cutillas PR(2011). Characterization of a TiO₂ enrichment method for label-free quantitative phosphoproteomics. Methods vol. 54, (4) 370-378.
Cutillas PR, Jørgensen C(2011). Biological signalling activity measurements using mass spectrometry. Biochem J vol. 434, (2) 189-199.
Casado P, Cutillas PR(2011). A self-validating quantitative mass spectrometry method for assessing the accuracy of high-content phosphoproteomic experiments. Mol Cell Proteomics vol. 10, (1)
Cutillas PR(2010). Analysis of peptides in biological fluids by LC-MS/MS. Methods Mol Biol vol. 658, 311-321.
Cutillas PR, Timms JF(2010). Approaches and applications of quantitative LC-MS for proteomics and activitomics. Methods Mol Biol vol. 658, 3-17.
Alcolea MP, Cutillas PR(2010). In-depth analysis of protein phosphorylation by multidimensional ion exchange chromatography and mass spectrometry. Methods Mol Biol vol. 658, 111-126.
Alcolea MP, Cutillas PR(2010). Quantification of protein kinase activities by LC-MS. Methods Mol Biol vol. 658, 325-337.
Cutillas PR(2009). Quantifying oncogenic signalling by mass spectrometry. AMINO ACIDS vol. 37, (4) 762-762.
Alcolea MP, Kleiner O, Cutillas PR(2009). Increased confidence in large-scale phosphoproteomics data by complementary mass spectrometric techniques and matching of phosphopeptide data sets. J Proteome Res vol. 8, (8) 3808-3815.
Quintana LF, Campistol JM, Alcolea MP, Banon-Maneus E, Sole-Gonzalez A, Cutillas PR(2009). Application of Label-free Quantitative Peptidomics for the Identification of Urinary Biomarkers of Kidney Chronic Allograft Dysfunction. MOL CELL PROTEOMICS vol. 8, (7) 1658-1673.
Vilasi A, Cutillas PR, Unwin RJ(2008). Application of proteomic techniques to the study of urine and renal tissue. PROTEOM CLIN APPL vol. 2, (12) 1564-1574.
Graupera M, Guillermet-Guibert J, Foukas LC, Phng LK, Cain RJ, Salpekar A, Pearce W, Meek S et al.(2008). Angiogenesis selectively requires the p110 alpha isoform of PI3K to control endothelial cell migration. NATURE vol. 453, (7195) 662-U9.
Cutillas PR, Vanhaesebroeck B(2007). Quantitative profile of five murine core proteomes using label-free functional proteomics. Mol Cell Proteomics vol. 6, (9) 1560-1573.
Vilasi A, Cutillas PR, Maher AD, Zirah SFM, Capasso G, Norden AWG, Holmes E, Nicholson JK et al.(2007). Combined proteomic and metabonomic studies in three genetic forms of the renal Fanconi syndrome. Am J Physiol Renal Physiol vol. 293, (2) F456-F467.
Cutillas PR, Vanhaesebroeck B(2007). Profiling protein expression by label-free quantitative mass Spectrometry. MOL CELL PROTEOMICS vol. 6, (8) 14-14.
Geering B, Cutillas PR, Nock G, Gharbi SI, Vanhaesebroeck B(2007). Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers. Proc Natl Acad Sci U S A vol. 104, (19) 7809-7814.
CUTILLAS PR, Vanhaesebroeck BAM, Khwaja A, Waterfield M, Gharbi S, Pearce W, Graupera M(2006). Ultrasensitive and absolute quantification of the phosphoinositide 3-kinase/Akt signal transduction pathway by mass spectrometry. Proc Natl Acad Sci USA vol. 103, (24) 8959-8964.
Cutillas PR, Geering B, Waterfield MD, Vanhaesebroeck B(2005). Quantification of gel-separated proteins and their phosphorylation sites by LC-MS using unlabeled internal standards: analysis of phosphoprotein dynamics in a B cell lymphoma cell line. Mol Cell Proteomics vol. 4, (8) 1038-1051.
CUTILLAS PR, Biber J, Marks J, Waterfield M, Cramer R, Stieger B, Jacob R, Burlingame AL et al.(2005). Proteomic analysis of plasma membrane vesicles isolated from the rat renal cortex. Proteomics vol. 5, (1) 101-112.
CUTILLAS PR, Burlingame AL, Waterfield MD, Norden AG, Cramer R, Hansen KC, Chalkley RJ, Unwin RJ(2004). The urinary proteome in Fanconi syndrome implies specificity in the reabsorption of proteins by renal proximal tubule cells. Am J Physiol Renal Physiol vol. 287, (3) F353-F364.
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