Publications: Dr Pedro Rodriguez Cutillas
Dembitz V, Lawson H, Burt R, Natani S, Philippe C, James SC, Atkinson S, Durko J et al.
(
2024
)
.
Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation
.
Leukemia1
-
15
.
Conduit SE, Pearce W, Bhamra A, Bilanges B, Bozal-Basterra L, Foukas LC, Cobbaut M, Castillo SD et al.
(
2024
)
.
A class I PI3K signalling network regulates primary cilia disassembly in normal physiology and disease
.
Nature Communications
vol.
15
,
(
1
)
Hirani P, McDermott J, Rajeeve V, Cutillas PR, Jones JL, Pennington DJ, Wight TN, Santamaria S et al.
(
2024
)
.
Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate
.
Cancer Research Communications
vol.
4
,
(
4
)
970
-
985
.
Branson N, Cutillas PR, Bessant C
(
2023
)
.
Comparison of multiple modalities for drug response prediction with learning curves using neural networks and XGBoost
.
Bioinformatics Advances
vol.
4
,
(
1
)
Koenis DS, de Matteis R, Rajeeve V, Cutillas P, Dalli J
(
2023
)
.
Efferocyte‐Derived MCTRs Metabolically Prime Macrophages for Continual Efferocytosis via Rac1‐Mediated Activation of Glycolysis
.
Advanced Science
vol.
11
,
(
7
)
Zheng J, Bewicke-Copley F, Vermeulen C, Casado P, Kaya F, Demeulemeester J, Guscott M, Krizsán S et al.
(
2023
)
.
Allele-Specific Expression of Leukemia Genes Is Associated with Pathogenicity in Poor Risk AML
.
Blood
vol.
142
,
(
Supplement 1
)
Kaya F, Bewicke-Copley F, Izquierdo PC, Zheng J, Miettinen JJ, Khan N, Krizsán S, Saad JJ et al.
(
2023
)
.
The XPO1-FOXC1-HOX Functional Axis Opens New Therapeutic Avenues to Treat DEK-NUP214 AML Patients
.
Blood
vol.
142
,
(
Supplement 1
)
Barry S, Rai A, Haworth O, Rajeeve V, Cutillas P, Korbonits M
(
2023
)
.
Integrated multi-omics data reveals distinct regulatory signatures and signaling pathways of aryl hydrocarbon receptor interacting protein (AIP) knockout cells
.
Endocrine Abstracts
Di Mambro A, Arroyo-Berdugo Y, Fioretti T, Randles M, Cozzuto L, Rajeeve V, Cevenini A, Austin MJ et al.
(
2023
)
.
SET-PP2A complex as a new therapeutic target in KMT2A (MLL) rearranged AML
.
Oncogene
vol.
42
,
(
50
)
3670
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3683
.
Yang M, Zhou X, Pearce SWA, Yang Z, Chen Q, Niu K, Liu C, Luo J et al.
(
2023
)
.
Causal Role for Neutrophil Elastase in Thoracic Aortic Dissection in Mice
.
Arteriosclerosis Thrombosis and Vascular Biology
vol.
43
,
(
10
)
1900
-
1920
.
Dokal A, Borek WE, Nobre L, Pedicona SF, Wrench B, Gallipoli P, Arruda A, Campbell AE et al.
(
2023
)
.
S124: PHOSPHOPROTEOMICS ACCURATELY PREDICTS RESPONSES TO MIDOSTAURIN PLUS CHEMOTHERAPY IN TWO INDEPENDENT COHORTS OF FLT3 MUTANT‐POSITIVE ACUTE MYELOID LEUKAEMIA
.
HemaSphere
vol.
7
,
(
Suppl
)
De Los Angeles Colomina Basanta C, Bazzi M, Hijazi M, Bessant C, Cutillas PR
(
2023
)
.
Community detection in empirical kinase networks identifies new potential members of signalling pathways
.
PLOS Computational Biology
vol.
19
,
(
6
)
Kassuhn W, Cutillas PR, Kessler M, Sehouli J, Braicu EI, Blüthgen N, Kulbe H
(
2023
)
.
In Silico Analysis Predicts Nuclear Factors NR2F6 and YAP1 as Mesenchymal Subtype-Specific Therapeutic Targets for Ovarian Cancer Patients
.
Cancers
vol.
15
,
(
12
)
Sarker D, Pedicona F, Zen Y, Borek WE, Khorsandi SE, Christopher J, Karampera C, Dowe T et al.
(
2023
)
.
Identification of novel phosphoproteomic biomarkers in patients with advanced hepatocellular carcinoma (HCC)
.
Journal of Clinical Oncology
vol.
41
,
(
16_suppl
)
e15155
-
e15155
.
Puttock EH, Tyler EJ, Manni M, Maniati E, Butterworth C, Burger Ramos M, Peerani E, Hirani P et al.
(
2023
)
.
Extracellular matrix educates an immunoregulatory tumor macrophage phenotype found in ovarian cancer metastasis
.
Nature Communications
vol.
14
,
(
1
)
Barry S, Haworth O, Rajeeve V, Cutillas P, Korbonits M
(
2023
)
.
Phosphoproteomics analysis of aryl hydrocarbon receptor interacting protein (AIP) knockout cells reveals AIP-mediated kinase signalling cascades
.
Endocrine Abstracts
Hirani P, Alonge KM, Pennington DJ, Cutillas PR, Wight TN, Pearce OM
(
2023
)
.
Abstract 5841: Exploring the role of versican in immune exclusion within triple negative breast cancer
.
Cancer Research
vol.
83
,
(
7_Supplement
)
5841
-
5841
.
Clayton NS, Carter EP, Fearon AE, Heward JA, Fernández LR, Boughetane L, Wilkes EH, Cutillas PR et al.
(
2023
)
.
HDAC Inhibition Restores Response to HER2-Targeted Therapy in Breast Cancer via PHLDA1 Induction
.
International Journal of Molecular Sciences
vol.
24
,
(
7
)
Higgins L, Gerdes H, Cutillas PR
(
2023
)
.
Principles of phosphoproteomics and applications in cancer research
.
Biochemical Journal
vol.
480
,
(
6
)
403
-
420
.
Grey W, Atkinson S, Rix B, Casado P, Ariza‐McNaughton L, Hawley C, Sopoena ML, Bridge KS et al.
(
2023
)
.
The CKS1/CKS2 Proteostasis Axis Is Crucial to Maintain Hematopoietic Stem Cell Function
.
HemaSphere
vol.
7
,
(
3
)
Casado P, Rio-Machin A, Miettinen JJ, Bewicke-Copley F, Rouault-Pierre K, Krizsan S, Parsons A, Rajeeve V et al.
(
2023
)
.
Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes
.
Signal Transduction and Targeted Therapy
vol.
8
,
(
1
)
Casado P, Cutillas PR
(
2023
)
.
Proteomic Characterization of Acute Myeloid Leukemia for Precision Medicine
.
Molecular & Cellular Proteomics
vol.
22
,
(
4
)
Hayat A, Carter EP, King HW, Ors A, Doe A, Teijeiro SA, Charrot S, Godinho S et al.
(
2023
)
.
Low HER2 enables dedifferentiation and transformation of normal breast epithelial cells via chromatin opening
.
Disease Models & Mechanisms
vol.
16
,
(
2
)
Dullovi A, Ozgencil M, Rajvee V, Tse WY, Cutillas PR, Martin SA, Hořejší Z
(
2023
)
.
Microtubule-associated proteins MAP7 and MAP7D1 promote DNA double-strand break repair in the G1 cell cycle phase
.
iScience
vol.
26
,
(
3
)
Prieto-Fernandez L, Villaronga MDLA, Hermida-Prado F, Hijazi M, Montoro-Jimenez I, Pevida M, Llames S, Rodrigo JP et al.
(
2023
)
.
Driving role of head and neck cancer cell secretome on the invasion of stromal fibroblasts: Mechanistic insights by phosphoproteomics
.
Biomedicine & Pharmacotherapy
vol.
158
,
Lopez-Gimenez JF, Martin-Estebane M, Lara-Ordonez AJ, Martin-Guerrero S, Cutillas PR, Martin-Oliva D, Gonzalez-Maesso J
(
2023
)
.
Generation and proteomic characterization of a neural stem cell model based on maternal immune activation (MIA) to be applied in psychopharmacology research
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
180
,
986
-
987
.
Sarker D, Pedicona F, Zen Y, Borek WE, Khorsandi SE, Christopher J, Karampera C, Dowe T et al.
(
2023
)
.
Identification of novel phosphoproteomic biomarkers in patients with advanced hepatocellular carcinoma (HCC)
.
JOURNAL OF CLINICAL ONCOLOGY
.
vol.
41
,
El-Mansi S, Robinson CL, Kostelnik KB, McCormack JJ, Mitchell TP, Lobato-Márquez D, Rajeeve V, Cutillas P et al.
(
2022
)
.
Proximity proteomics identifies septins and PAK2 as decisive regulators of actomyosin-mediated expulsion of von Willebrand factor
.
Blood
vol.
141
,
(
8
)
930
-
944
.
Badshah II, Cutillas PR
(
2022
)
.
Systematic identification of biochemical networks in cancer cells by Functional Pathway Inference Analysis
.
Bioinformatics
Rio-Machin A, Bewicke-Copley F, Zheng J, Izquierdo PC, Miettinen JJ, Khan N, Demeulemeester J, Krizsán S et al.
(
2022
)
.
Deep Multi-Omics Profiling in Cytogenetically Poor-Risk AML
.
Blood
vol.
140
,
(
Supplement 1
)
1030
-
1032
.
Dembitz V, Lawson H, Philippe C, Burt RJ, James S, Magee ASM, Woodley K, Durko J et al.
(
2022
)
.
Inhibition of Stearoyl-CoA Desaturase Has Anti-Leukemic Properties in Acute Myeloid Leukemia
.
Blood
vol.
140
,
(
Supplement 1
)
3058
-
3060
.
Williams JL, Paudyal A, Stewart M, Cutillas P, Tinker A, Metherell L
(
2022
)
.
Abstract P2005: Loss Of Full-length Mylk3 Causes Dilated Cardiomyopathy Via A MYL2-independent Mechanism
.
Circulation Research
vol.
131
,
(
Suppl_1
)
ap2005
-
ap2005
.
Grey W, Rio-Machin A, Casado P, Grönroos E, Ali S, Miettinen JJ, Bewicke-Copley F, Parsons A et al.
(
2022
)
.
CKS1 inhibition depletes leukemic stem cells and protects healthy hematopoietic stem cells in acute myeloid leukemia
.
Science Translational Medicine
vol.
14
,
(
650
)
eabn3248
-
eabn3248
.
Woodward L, Jones TA, Patel A, Dokal AD, Stone TJ, Rajeeve V, Cutillas PR, Jones DTW et al.
(
2022
)
.
LGG-44. Multi-omic analysis reveals integrated signalling networks in paediatric low-grade glioma
.
Neuro-Oncology
vol.
24
,
(
Supplement_1
)
i98
-
i98
.
Grey W, Rio‐Machin A, Casado‐Izquierdo P, Gronroos E, Ali S, Miettinen J, Bewicke‐Copley F, Parsons A et al.
(
2022
)
.
P405: INHIBITION OF CKS1‐DEPENDENT PROTEOSTASIS REVEALS VULNERABILITIES IN LEUKAEMIC STEM CELLS WITH CONCOMITANT PROTECTION OF HEALTHY HAEMATOPOIETIC STEM CELLS
.
HemaSphere
vol.
6
,
305
-
306
.
Thorup AS, Wilson J, Cutillas P, Dell’accio F
(
2022
)
.
POS0229 ELUCIDATING THE MECHANISM OF ACTION DOWNSTREAM OF ROR2 BLOCKADE: A PHOSPHOPROTEOMIC APPROACH
.
Annals of the Rheumatic Diseases
.
vol.
81
,
351.2
-
35351
.
Thompson EM, Patel V, Rajeeve V, Cutillas PR, Stoker AW
(
2022
)
.
The cytotoxic action of BCI is not dependent on its stated DUSP1 or DUSP6 targets in neuroblastoma cells
.
FEBS Open Bio
vol.
12
,
(
7
)
1388
-
1405
.
Hijazi M, Casado P, Akhtar N, Alvarez-Teijeiro S, Rajeeve V, Cutillas PR
(
2022
)
.
eEF2K Activity Determines Synergy to Cotreatment of Cancer Cells With PI3K and MEK Inhibitors
.
Molecular & Cellular Proteomics
vol.
21
,
(
6
)
Pedicona F, Casado P, Hijazi M, Gribben JG, Rouault-Pierre K, Cutillas PR
(
2022
)
.
Targeting the lysine-specific demethylase 1 rewires kinase networks and primes leukemia cells for kinase inhibitor treatment
.
Science Signaling
vol.
15
,
(
730
)
Thorup A-S, Wilson J, Strachan D, Caxaria S, Poulet B, Thomas B, Eldridge S, Nalesso G et al.
(
2022
)
.
BLOCKING ROR2 IMPROVES CARTILAGE INTEGRITY AND PROVIDES PAIN RELIEF IN OSTEOARTHRITIS, IN PART BY MODULATING YAP SIGNALLING
.
Osteoarthritis and Cartilage
vol.
30
,
Roy-Luzarraga M, Reynolds LE, de Lux�n-Delgado B, Maiques O, Wisniewski L, Newport E, Rajeeve V, Drake RJG et al.
(
2022
)
.
Suppression of endothelial cell FAK expression reduces pancreatic ductal adenocarcinoma metastasis after gemcitabine treatmentEC FAK regulates gemcitabine treated liver metastasis
.
Cancer Research
vol.
82
,
(
10
)
1909
-
1925
.
Murray ER, Menezes S, Henry JC, Williams JL, Alba-Castellón L, Baskaran P, Quétier I, Desai A et al.
(
2022
)
.
Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion
.
Cell Reports
vol.
38
,
(
4
)
Grey W, Rio-Machin A, Casado-Izquierdo P, Gronroos E, Ali S, Miettinen J, Copley FB, Parsons A et al.
(
2022
)
.
3094 – INHIBITION OF CKS1-DEPENDENT PROTEOSTASIS REVEALS VULNERABILITIES IN LEUKAEMIC STEM CELLS WITH CONCOMITANT PROTECTION OF HEALTHY HAEMATOPOIESIS
.
Experimental Hematology
vol.
111
,
s91
-
s92
.
Woodward L, Jones TA, Patel A, Dokal AD, Stone TJ, Rajeeve V, Cutillas PR, Jones DTW et al.
(
2022
)
.
MULTI-OMIC ANALYSIS REVEALS INTEGRATED SIGNALLING NETWORKS IN PAEDIATRIC LOW-GRADE GLIOMA
.
NEURO-ONCOLOGY
.
vol.
24
,
98
-
98
.
Newport E, Pedrosa AR, Lees D, Dukinfield M, Carter E, Gomez‐Escudero J, Casado P, Rajeeve V et al.
(
2021
)
.
Elucidating the role of the kinase activity of endothelial cell focal adhesion kinase in angiocrine signalling and tumour growth
.
The Journal of Pathology
vol.
256
,
(
2
)
235
-
247
.
Casado P, Hijazi M, Gerdes H, Cutillas PR
(
2021
)
.
Implementation of Clinical Phosphoproteomics and Proteomics for Personalized Medicine
.
Clinical Proteomics
,
vol.
2420
,
Springer Nature
Nobre LV, Basanta CC, Pedicona SF, Dokal AD, Arruda A, Smith R, Greenhalgh C, Patella F et al.
(
2021
)
.
Abstract LBA013: Phosphoproteomics reveals active drug targets on pathways of resistance and predicts response to midostaurin plus chemotherapy in FLT3 mutant-positive acute myeloid leukemia
.
Molecular Cancer Therapeutics
.
vol.
20
,
lba013
-
lba013
.
Williams J, paudyal A, Stewart M, Cutillas P, Cox RD, Tinker A, Metherell L
(
2021
)
.
Abstract 14037: A Shorter Myosin Light Chain Kinase 3 Isoform Maintains Myosin Light Chain 2 Phosphorylation but Does Not Attenuate the Dilated Cardiomyopathy Seen in C57BL/6N Mice
.
Circulation
vol.
144
,
(
Suppl_1
)
a14037
-
a14037
.
Davidson K, Grevitt P, Contreras-Gerenas MF, Bridge KS, Hermida M, Shah KM, Mardakheh FK, Stubbs M et al.
(
2021
)
.
Targeted therapy for LIMD1-deficient non-small cell lung cancer subtypes
.
Cell Death & Disease
vol.
12
,
(
11
)
Nobre LMVV, Pedicona SF, Dokal A, Arruda A, Smith R, Greenhalgh C, Patella F, Casado-Izquierdo P et al.
(
2021
)
.
Proteomics and Phospho-Proteomics Reveal Predictive Signatures of Response and Mechanisms of Resistance to Midostaurin Plus Chemotherapy in FLT3 Mutant Positive Acute Myeloid Leukemia
.
Blood
vol.
138
,
(
Supplement 1
)
Lecker LSM, Berlato C, Maniati E, Delaine-Smith R, Pearce OMT, Heath O, Nichols SJ, Trevisan C et al.
(
2021
)
.
TGFBI Production by Macrophages Contributes to an Immunosuppressive Microenvironment in Ovarian CancerTGFBI and Ovarian Cancer
.
Cancer Research
vol.
81
,
(
22
)
5706
-
5719
.
Khorsandi SE, Dokal AD, Rajeeve V, Britton DJ, Illingworth MS, Heaton N, Cutillas PR
(
2021
)
.
Computational Analysis of Cholangiocarcinoma Phosphoproteomes Identifies Patient-Specific Drug TargetsCholangiocarcinoma Phosphoproteomics and Machine Learning
.
Cancer Research
vol.
81
,
(
22
)
5765
-
5776
.
Heydt Q, Xintaropoulou C, Clear A, Austin M, Pislariu I, Miraki-Moud F, Cutillas P, Korfi K et al.
(
2021
)
.
Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence
.
Nature Communications
Freire-Benéitez V, Pomella N, Millner TO, Dumas AA, Niklison-Chirou MV, Maniati E, Wang J, Rajeeve V et al.
(
2021
)
.
Correction to ‘Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma’
.
NAR Cancer
vol.
3
,
(
2
)
Dokal AD, Arruda A, Smith R, Greenhalgh C, Patella F, Casado-Izquierdo PM, Wrench B, Theaker J et al.
(
2021
)
.
Predictive phosphoproteomic signatures for midostaurin plus chemotherapy response in FLT3 mutant positive acute myeloid leukaemia
.
Journal of Clinical Oncology
vol.
39
,
(
15_suppl
)
7019
-
7019
.
Gualtieri A, Kyprianou N, Gregory LC, Vignola ML, Nicholson JG, Tan R, Inoue S-I, Scagliotti V et al.
(
2021
)
.
Activating mutations in BRAF disrupt the hypothalamo-pituitary axis leading to hypopituitarism in mice and humans
.
Nature Communications
vol.
12
,
(
1
)
Heward J, Konali L, D'Avola A, Close K, Yeomans A, Philpott M, Dunford J, Rahim T et al.
(
2021
)
.
KDM5 inhibition offers a novel therapeutic strategy for the treatment of KMT2D mutant lymphomas
.
Blood
vol.
138
,
(
5
)
370
-
381
.
Gerdes H, Casado P, Dokal A, Hijazi M, Akhtar N, Osuntola R, Rajeeve V, Fitzgibbon J et al.
(
2021
)
.
Drug ranking using machine learning systematically predicts the efficacy of anti-cancer drugs
.
Nature Communications
vol.
12
,
(
1
)
Freire-Benéitez V, Pomella N, Millner TO, Dumas AA, Niklison-Chirou MV, Maniati E, Wang J, Rajeeve V et al.
(
2021
)
.
Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma
.
NAR Cancer
vol.
3
,
(
1
)
Martín-Guerrero SM, Alonso P, Iglesias A, Cimadevila M, Brea J, Loza MI, Casado P, Martín-Oliva D et al.
(
2021
)
.
His452Tyr polymorphism in the human 5-HT2A receptor affects clozapine-induced signaling networks revealed by quantitative phosphoproteomics
.
Biochemical Pharmacology
vol.
185
,
Bradley D, Viéitez C, Rajeeve V, Selkrig J, Cutillas PR, Beltrao P
(
2021
)
.
Sequence and Structure-Based Analysis of Specificity Determinants in Eukaryotic Protein Kinases
.
Cell Reports
vol.
34
,
(
2
)
Edelmann J, Dokal AD, Vilventhraraja E, Holzmann K, Britton D, Klymenko T, Döhner H, Cragg M et al.
(
2021
)
.
Rituximab and obinutuzumab differentially hijack the B-cell receptor and NOTCH1 signaling pathways
.
iScience102089
-
102089
.
Patel A, Jones T, Woodward L, Dokal A, Rajeeve V, Cutillas P, Stone T, Jacques T et al.
(
2020
)
.
LGG-57. SIGNALLING MECHANISMS IN PAEDIATRIC LOW-GRADE GLIOMA
.
Neuro-Oncology
vol.
22
,
(
Suppl 3
)
iii377
-
iii377
.
Martín-Guerrero SM, Casado P, Hijazi M, Rajeeve V, Plaza-Díaz J, Abadía-Molina F, Navascués J, Cuadros MA et al.
(
2020
)
.
PARP-1 activation after oxidative insult promotes energy stress-dependent phosphorylation of YAP1 and reduces cell viability
.
Biochemical Journal
vol.
477
,
(
23
)
4491
-
4513
.
Rio-Machin A, Casado-Izquierdo P, Miettinen J, Bewicke-Copley F, Khan N, Demeulemeester J, Krizsán S, Zheng J et al.
(
2020
)
.
Integration of Deep Multi-Omics Profiling Veals New Insights into the Biology of Poor-Risk Acute Myeloid Leukemia
.
Blood
vol.
136
,
(
Supplement 1
)
39
-
40
.
Fernández‐Varo G, Perramón M, Carvajal S, Oró D, Casals E, Boix L, Oller L, Macías‐Muñoz L et al.
(
2020
)
.
Bespoken Nanoceria: An Effective Treatment in Experimental Hepatocellular Carcinoma
.
Hepatology
vol.
72
,
(
4
)
1267
-
1282
.
Akhtar N, Baig MW, Haq I-U, Rajeeve V, Cutillas PR
(
2020
)
.
Withanolide Metabolites Inhibit PI3K/AKT and MAPK Pro-Survival Pathways and Induce Apoptosis in Acute Myeloid Leukemia Cells
.
Biomedicines
vol.
8
,
(
9
)
Gadaleta E, Fourgoux P, Pirró S, Thorn GJ, Nelan R, Ironside A, Rajeeve V, Cutillas PR et al.
(
2020
)
.
Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer
.
npj Breast Cancer
vol.
6
,
(
1
)
Gadaleta E, Fourgoux P, Pirró S, Thorn GJ, Nelan R, Ironside A, Rajeeve V, Cutillas PR et al.
(
2020
)
.
Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer
.
NPJ Breast Cancer
vol.
6
,
(
1
)
Xu R, Jones W, Wilcz‐Villega E, Costa AS, Rajeeve V, Bentham RB, Bryson K, Nagano A et al.
(
2020
)
.
The breast cancer oncogene IKKε coordinates mitochondrial function and serine metabolism
.
EMBO Reports
vol.
21
,
(
9
)
Patani H, Rushton MD, Higham J, Teijeiro SA, Oxley D, Cutillas P, Sproul D, Ficz G
(
2020
)
.
Transition to naïve human pluripotency mirrors pan-cancer DNA hypermethylation
.
Nature Communications
vol.
11
,
(
1
)
Wong P-P, Muñoz-Félix JM, Hijazi M, Kim H, Robinson SD, De Luxán-Delgado B, Rodríguez-Hernández I, Maiques O et al.
(
2020
)
.
Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk with Tumor Cells
.
Cell
vol.
181
,
(
6
)
1346
-
1363.e21
.
Kostaras E, Kaserer T, Lazaro G, Heuss SF, Hussain A, Casado P, Hayes A, Yandim C et al.
(
2020
)
.
A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity
.
British Journal of Cancer
vol.
123
,
(
4
)
542
-
555
.
Invergo BM, Petursson B, Akhtar N, Bradley D, Giudice G, Hijazi M, Cutillas P, Petsalaki E et al.
(
2020
)
.
Prediction of Signed Protein Kinase Regulatory Circuits
.
Cell Systems
vol.
10
,
(
5
)
384
-
396.e9
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43
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Alcolea MP, Casado P, Rodríguez-Prados J-C, Vanhaesebroeck B, Cutillas PR
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Phosphoproteomic analysis of leukemia cells under basal and drug-treated conditions identifies markers of kinase pathway activation and mechanisms of resistance
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Mol Cell Proteomics
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Kitromilidou C, McDonald D, Cutillas P, Ghazaly E, Perry J, Csaba B, Joel S, Powles T
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Abstract 1792: The potential role of targeting HER1-4 in bladder cancer
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Cancer Research
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Kulbe H, Chakravarty P, Moore R, Iorio F, Montoya A, Saez-Rodriguez J, Cutillas P, Balkwill F
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Abstract 49: Targeting the TNF network in human ovarian cancer - A systems biology approach
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Cancer Research
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72
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49
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49
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Burling KA, Cutillas PR, Church D, Lapsley M, Norden AGW
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Analysis of molecular forms of urine Retinol-Binding Protein in Fanconi Syndrome and design of an accurate immunoassay
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CLINICA CHIMICA ACTA
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Cappadona S, Baker PR, Cutillas PR, Heck AJR, van Breukelen B
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Current challenges in software solutions for mass spectrometry-based quantitative proteomics
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AMINO ACIDS
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43
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1087
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Beltran L, Chaussade C, Vanhaesebroeck B, Cutillas PR
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Calpain interacts with class IA phosphoinositide 3-kinases regulating their stability and signaling activity
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Proc Natl Acad Sci U S A
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Montoya A, Beltran L, Casado P, Rodríguez-Prados J-C, Cutillas PR
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Characterization of a TiO₂ enrichment method for label-free quantitative phosphoproteomics
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Methods
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Cutillas PR, Jørgensen C
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Biological signalling activity measurements using mass spectrometry
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Biochem J
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A self-validating quantitative mass spectrometry method for assessing the accuracy of high-content phosphoproteomic experiments
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Mol Cell Proteomics
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Worthington J, Cutillas PR, Timms JF
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IMAC/TiO<sub>2</sub> enrich for peptide modifications other than phosphorylation: Implications for chromatographic choice and database searching in phosphoproteomics
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PROTEOMICS
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Timms JF, Cutillas PR
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Overview of Quantitative LC-MS Techniques for Proteomics and Activitomics
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LC-MS/MS in Proteomics
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658
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Jueliger S, Maharaj L, Iyengar S, Ghazaly E, Cutillas P, Auer R, Rommel C, Li L et al.
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2010
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Abstract 4489: The activity of novel, potent, selective PI3K/mTOR pathway inhibitors in B-cell malignancies
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Cancer Research
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Cutillas PR
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Analysis of peptides in biological fluids by LC-MS/MS
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Methods Mol Biol
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Approaches and applications of quantitative LC-MS for proteomics and activitomics
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Methods Mol Biol
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Alcolea MP, Cutillas PR
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In-depth analysis of protein phosphorylation by multidimensional ion exchange chromatography and mass spectrometry
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Methods Mol Biol
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Alcolea MP, Cutillas PR
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Quantification of protein kinase activities by LC-MS
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Cutillas PR
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Quantifying oncogenic signalling by mass spectrometry
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AMINO ACIDS
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Alcolea MP, Kleiner O, Cutillas PR
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Increased confidence in large-scale phosphoproteomics data by complementary mass spectrometric techniques and matching of phosphopeptide data sets
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J Proteome Res
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Quintana LF, Campistol JM, Alcolea MP, Banon-Maneus E, Sole-Gonzalez A, Cutillas PR
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Application of Label-free Quantitative Peptidomics for the Identification of Urinary Biomarkers of Kidney Chronic Allograft Dysfunction
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MOL CELL PROTEOMICS
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Vilasi A, Cutillas PR, Unwin RJ
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Application of proteomic techniques to the study of urine and renal tissue
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PROTEOM CLIN APPL
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1564
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Capasso G, Debnam ES, Cutillas PR, Brunskill NJ, Unwin RJ
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Classical and Novel Hormonal Influences on Renal Tubular Transport, and the Emerging Concept of Intracrine Regulation
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Seldin and Giebisch's The Kidney
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Graupera M, Guillermet-Guibert J, Foukas LC, Phng LK, Cain RJ, Salpekar A, Pearce W, Meek S et al.
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Angiogenesis selectively requires the p110 alpha isoform of PI3K to control endothelial cell migration
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NATURE
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662
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Capasso G, Debnam ES, Cutillas PR, Brunski NJ, Unwin RJ
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CHAPTER 35 Classical and Novel Hormonal Influences on Renal Tubular Transport, and the Emerging Concept of Intracrine Regulation
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Seldin and Giebisch's The Kidney
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Elsevier
Capasso G, Debnam ES, Cutillas PR, Brunskill NJ, Unwin RJ
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2007
)
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Classical and Novel Hormonal Influences on Renal Tubular Transport, and the Emerging Concept of Intracrine Regulation
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Seldin and Giebisch's The Kidney: Physiology & Pathophysiology 1-2
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Cutillas PR, Vanhaesebroeck B
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Quantitative profile of five murine core proteomes using label-free functional proteomics
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Mol Cell Proteomics
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Cutillas PR, Vanhaesebroeck B
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Profiling protein expression by label-free quantitative mass Spectrometry
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MOL CELL PROTEOMICS
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Cutillas PR
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Quantification of Polypeptides by Mass Spectrometry
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Peptidomics
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Wiley
Vilasi A, Cutillas PR, Maher AD, Zirah SFM, Capasso G, Norden AWG, Holmes E, Nicholson JK et al.
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Combined proteomic and metabonomic studies in three genetic forms of the renal Fanconi syndrome
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American Journal of Physiology. Renal physiology
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Geering B, Cutillas PR, Nock G, Gharbi SI, Vanhaesebroeck B
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Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers
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Proc Natl Acad Sci U S A
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VANHAESEBROECK BAM, Gharbi SL, Nock G, Geering B, Cutillas PR
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Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers
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Proc Natl Acad Sci U S A
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Correction
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Clinical Chemistry
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Geering B, Cutillas PR, Vanhaesebroeck B
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Regulation of class IA PI3Ks: is there a role for monomeric PI3K subunits?
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Biochemical Society Transactions
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Norden AG, Rodriguez-Cutillas P, Unwin RJ
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Clinical Urinary Peptidomics: Learning to Walk Before We Can Run
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Clinical Chemistry
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375
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376
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Thongboonkerd V, Cutillas PR, Unwin RJ, Schaub S, Nickerson P, Haubitz M, Mischak H, Nedelkov D et al.
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2007
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Proteomics of Human Urine
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Proteomics of Human Body Fluids
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CUTILLAS PR, Vanhaesebroeck BAM, Khwaja A, Waterfield M, Gharbi S, Pearce W, Graupera M
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Ultrasensitive and absolute quantification of the phosphoinositide 3-kinase/Akt signal transduction pathway by mass spectrometry
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Proc Natl Acad Sci USA
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8959
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Cutillas PR, Geering B, Waterfield MD, Vanhaesebroeck B
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2005
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Quantification of gel-separated proteins and their phosphorylation sites by LC-MS using unlabeled internal standards: analysis of phosphoprotein dynamics in a B cell lymphoma cell line
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Mol Cell Proteomics
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1038
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CUTILLAS PR, Biber J, Marks J, Waterfield M, Cramer R, Stieger B, Jacob R, Burlingame AL et al.
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Proteomic analysis of plasma membrane vesicles isolated from the rat renal cortex
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Proteomics
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Cutillas PR, Norden AGW, Cramer R, Burlingame AL, Unwin RJ
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Urinary Proteomics of Renal Fanconi Syndrome
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Contributions to Nephrology
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Norden AGW, Sharratt P, Cutillas PR, Cramer R, Gardner SC, Unwin RJ
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2004
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Quantitative amino acid and proteomic analysis: Very low excretion of polypeptides >750 Da in normal urine
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Kidney International
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CUTILLAS PR, Burlingame AL, Waterfield MD, Norden AG, Cramer R, Hansen KC, Chalkley RJ, Unwin RJ
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The urinary proteome in Fanconi syndrome implies specificity in the reabsorption of proteins by renal proximal tubule cells
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Am J Physiol Renal Physiol
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Cutillas P, Burlingame A, Unwin R
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2004
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Proteomic Strategies and Their Application in Studies of Renal Function
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Physiology
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CUTILLAS PR, NORDEN AGW, CRAMER R, BURLINGAME AL, UNWIN RJ
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Detection and analysis of urinary peptides by on-line liquid chromatography and mass spectrometry: application to patients with renal Fanconi syndrome
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Clinical Science
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Cutillas PR, Cramer R, Unwin R, Burlingame A
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2002
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A column-switching LC-MS/MS set-up for the 'clean-up', separation and characterization of peptides present in small volumes of biological fluids
.
Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics
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363
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364
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