Publications: Dr Emanuela Carlotti
Passman AM, Haughey MJ, Carlotti E, Williams MJ, Cereser B, Lin ML, Devkumar S, Gabriel JP et al.
(
2023
)
.
Hepatocytes undergo punctuated expansion dynamics from a periportal stem cell niche in normal human liver
.
Journal of Hepatology
vol.
79
,
(
2
)
417
-
432
.
Carlotti E, Murray-Brown W, Blighe K, Caliste M, Astorri E, Sutcliffe N, Tappuni AR, Pitzalis C et al.
(
2022
)
.
High-throughput sequencing of IgH gene in minor salivary glands from Sjögren’s syndrome patients reveals dynamic B cell recirculation between ectopic lymphoid structures
.
Clinical and Experimental Rheumatology
vol.
40
,
(
12
)
2363
-
2372
.
Michaeli M, Carlotti E, Hazanov H, Gribben JG, Mehr R
(
2022
)
.
Mutational patterns along different evolution paths of follicular lymphoma
.
Frontiers in Oncology
vol.
12
,
Lin M-L, Hickey JW, Schürch CM, Carlotti E, Passman AM, Hackett RJ, Devkumar S, Evans JA et al.
(
2022
)
.
Tu1165: THE IMMUNE CELL MICROENVIRONMENT IS DIFFERENTIALLY-ALTERED ACCORDING TO DIVERSE EPITHELIAL LANDSCAPES IN THE PROGRESSION TO CANCER IN BARRETT OESOPHAGUS
.
Gastroenterology
vol.
162
,
(
7
)
s
-
332
.
Evans JA, Carlotti E, Lin ML, Hackett RJ, Haughey MJ, Passman AM, Dunn L, Elia G et al.
(
2022
)
.
Clonal Transitions and Phenotypic Evolution in Barrett's Esophagus
.
Gastroenterology
vol.
162
,
(
4
)
1197
-
1209.e13
.
Lin M-L, Hickey JW, Schurch CM, Carlotti E, Passman AM, Hackett RJ, Devkumar S, Evans JA et al.
(
2022
)
.
THE IMMUNE CELL MICROENVIRONMENT IS DIFFERENTIALLY-ALTERED ACCORDING TO DIVERSE EPITHELIAL LANDSCAPES IN THE PROGRESSION TO CANCER IN BARRETT OESOPHAGUS
.
GASTROENTEROLOGY
.
vol.
162
,
S332
-
S332
.
Passman AM, Haughey MJ, Carlotti E, Williams M, Cereser B, Russo FP, Hoare M, Kocher H et al.
(
2020
)
.
450 CLONAL DYNAMICS AND CELL-OF-ORIGIN OF NORMAL HEPATOCYTE EXPANSIONS IN HOMEOSTATIC HUMAN LIVERS AND THEIR ASSOCIATION WITH THE BILIARY EPITHELIUM
.
Gastroenterology
vol.
158
,
(
6
)
s
-
1276
.
Passman AM, Haughey MJ, Carlotti E, Williams M, Cereser B, Russo FP, Hoare M, Kocher H et al.
(
2020
)
.
CLONAL DYNAMICS AND CELL-OF-ORIGIN OF NORMAL HEPATOCYTE EXPANSIONS IN HOMEOSTATIC HUMAN LIVERS AND THEIR ASSOCIATION WITH THE BILIARY EPITHELIUM
.
GASTROENTEROLOGY
.
Conference:
AACR
vol.
158
,
S1276
-
S1276
.
Corsiero E, Carlotti E, Jagemann L, Perretti M, Pitzalis C, Bombardieri M
(
2020
)
.
H and L chain affinity maturation and/or Fab N-glycosylation influence immunoreactivity toward neutrophil extracellular trap antigens in rheumatoid arthritis synovial b cell clones
.
Journal of Immunology
vol.
204
,
(
9
)
2374
-
2379
.
Krysov S, Odabashian M, Carlotti E, Araf S, Okosun J, Spada F, Gribben J, Forconi F et al.
(
2020
)
.
IGHV sequencing reveals acquired N-glycosylation sites as a clonal and stable event during follicular lymphoma evolution
.
Blood
vol.
135
,
(
11
)
834
-
844
.
Passman A, Williams M, Carlotti E, Cereser B, Hoare M, Russo F, Kocher HM, Chin-Aleong J et al.
(
2019
)
.
The Cell of Origin of Normal Human Hepatocytes has a Common Ancestor with Biliary Epithelium and Hepatocyte Clonal Expansions Arise from the Portal Tract and Drift to the Central Vein
.
JOURNAL OF PATHOLOGY
.
vol.
249
,
S16
-
S16
.
Odabashian M, Carlotti E, Araf S, Okosun J, Forconi F, Stevenson FK, Gribben JG, Calaminici M et al.
(
2018
)
.
Immunoglobulin Variable Region Gene Sequences Reveal N-Glycosylation Motifs As an Early and Stable Event in Follicular Lymphoma Pathology
.
Blood
.
Conference:
Search Results Web results ASH Meeting on Lymphoma Biology
vol.
132
,
4101
-
4101
.
Evans J, Carlotti E, Williams M, Preston SL, Rodriguez-Justo M, Wright NA, Graham TA, Jansen M et al.
(
2018
)
.
335 - Lineage Tracing in Barrett's Esophagus Reveals both its Origins and Evolution and Suggests that Gland Diversity may be an Important Biomarker for the Progression to Dysplasia in Patients
.
Gastroenterology
vol.
154
,
(
6
)
s
-
84
.
Evans J, Carlotti E, Williams M, Preston SL, Rodriguez-Justo M, Wright NA, Graham TA, Jansen M et al.
(
2018
)
.
LINEAGE TRACING IN BARRETT'S ESOPHAGUS REVEALS BOTH ITS ORIGINS AND EVOLUTION AND SUGGESTS THAT GLAND DIVERSITY MAY BE AN IMPORTANT BIOMARKER FOR THE PROGRESSION TO DYSPLASIA IN PATIENTS
.
GASTROENTEROLOGY
.
vol.
154
,
S84
-
S84
.
Murray-Brown W, Carlotti E, Floyd J, Sutcliffe N, Tappuni A, Vartoukian S, Fortune F, Mehr R et al.
(
2016
)
.
Next-generation sequencing demonstrates dynamic recirculation of B cell clones in ectopic lymphoid structures of Sjogren's syndrome
.
EUROPEAN JOURNAL OF IMMUNOLOGY
.
Conference:
European League Against Rheumatism
vol.
46
,
939
-
940
.
Corsiero E, Carlotti E, Prediletto E, Jagemann L, Pitzalis C, Bombardieri M
(
2016
)
.
A2.04 The role of somatic hypermutation and n-glycosylation in the anti-nets immunoreactivity of ra synovial monoclonal antibodies
.
Annals of the Rheumatic Diseases
.
vol.
75
,
Corsiero E, Carlotti E, Prediletto E, Jagemann L, Pitzalis C, Bombardieri M
(
2016
)
.
The role of somatic hypermutation and N-glycosylation in the anti-NET immunoreactivity of RA synovial monoclonal antibodies
.
EUROPEAN JOURNAL OF IMMUNOLOGY
.
vol.
46
,
116
-
117
.
Corsiero E, Bombardieri M, Carlotti E, Pratesi F, Robinson W, Migliorini P, Pitzalis C
(
2015
)
.
Single cell cloning and recombinant monoclonal antibodies generation from RA synovial B cells reveal frequent targeting of citrullinated histones of NETs
.
Annals of the Rheumatic Diseases1866
-
1875
.
Carlotti E, Wrench D, Rosignoli G, Marzec J, Sangaralingam A, Hazanov L, Michaeli M, Hallam S et al.
(
2015
)
.
High throughput sequencing analysis of the immunoglobulin heavy chain gene from flow-sorted B cell sub-populations define the dynamics of follicular lymphoma clonal evolution
.
PLoS ONE
vol.
10
,
(
9
)
Corsiero E, Carlotti E, Pitzalis C, Bombardieri M
(
2015
)
.
FRI0007 The Importance of Somatic Hypermutation for the Immunoreactivity Towards Neutrophil Extracellular Traps (NETS)-Citrullinated Autoantigens of Ra Synovial Monoclonal Antibodies
.
Annals of the Rheumatic Diseases
.
vol.
74
,
Carlotti E, Floyd J, Murray-Brown W, Barnes M, Mehr R, Bombardieri M, Pitzalis C
(
2015
)
.
FRI0008 Longitudinal Analysis of the IGH-VH Gene by High-Throughput Sequencing in Early Rheumatoid Arthritis Paired Biopsies and its Association with Response to Dmards
.
Annals of the Rheumatic Diseases
.
vol.
74
,
Murray-Brown W, Carlotti E, Floyd J, Sutcliffe N, Tappuni A, Vartoukian S, Fortune F, Mehr R et al.
(
2015
)
.
FRI0020 Next-Generation Sequencing Demonstrates Dynamic Recirculation of B Cell Clones in Ectopic Lymphoid Structures of Sjögren's Syndrome
.
Annals of the Rheumatic Diseases
.
vol.
74
,
Murray-Brown W, Carlotti E, Tappuni A, Sutcliffe N, Pitzalis C, Bombardieri M
(
2015
)
.
Next-Generation Sequencing Demonstrates Dynamic Recirculation of B Cell Clones in Ectopic Lymphoid Structures of Sjogren's Syndrome
.
ARTHRITIS & RHEUMATOLOGY
vol.
67
,
Corsiero E, Carlotti E, Pitzalis C, Bombardieri M
(
2015
)
.
The Importance of Somatic Hypermutation for the Immunoreactivity Towards Neutrophil Extracellular Traps (NETs)-Citrullinated Autoantigens of RA Synovial Monoclonal Antibodies
.
ARTHRITIS & RHEUMATOLOGY
vol.
67
,
Corsiero E, Carlotti E, Pratesi F, Wardemann H, Robinson W, Migliorini P, Pitzalis C, Bombardieri M
(
2014
)
.
OP0266 Monoclonal Antibodies Derived from Single CD19+ Synovial B Cells of RA Patients with Tertiary Lymphoid Structures Display Preferential Immunoreactivity towards Citrullinated Proteins of Nets
.
Annals of the Rheumatic Diseases
.
vol.
73
,
Okosun J, Bödör C, Wang J, Araf S, Yang CY, Pan C, Boller S, Cittaro D et al.
(
2014
)
.
Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma
.
Nature Genetics
vol.
46
,
(
2
)
176
-
181
.
Okosun J, Bödör C, Wang J, Araf S, Yang C-Y, Pan C, Boller S, Cittaro D et al.
(
2014
)
.
Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma
.
Nat Genet
vol.
46
,
(
2
)
176
-
181
.
Corsiero E, Carlotti E, Wardemann H, Robinson W, Migliorini P, Pratesi F, Pitzalis C, Bombardieri M
(
2014
)
.
A1.31 Monoclonal antibodies from CD19+ synovial B cells of RA patients with tertiary lymphoid structures display a strong immunoreactivity towards citrullinated histones from neutrophils NETs
.
Annals of the Rheumatic Diseases
.
vol.
73
,
Corsiero E, Bombardieri M, Carlotti E, Pratesi F, Robinson W, Migliorini P, Pitzalis C
(
2014
)
.
Citrullinated histones from neutrophil extracellular traps (NETs) fuel ectopic germinal centre responses and ACPA production in rheumatoid joints
.
IMMUNOLOGY
vol.
143
,
43
-
43
.
Corsiero E, Bombardieri M, Carlotti E, Wardemann H, Robinson WH, Pitzalis C
(
2013
)
.
Recombinant Monoclonal Antibodies Derived From Single CD19+Synovial B Cells Of RA Patients With Tertiary Lymphoid Structures Display a Strong Immunoreactivity Towards Citrullinated Histones
.
ARTHRITIS AND RHEUMATISM
.
vol.
65
,
S1127
-
S1128
.
Okosun J, Boedoer C, Wang J, Araf S, Marzec J, Iqbal S, Matthews J, Calaminici M et al.
(
2012
)
.
Whole Genome Sequencing in Sequential Biopsies Reveals the Genetic Evolution of Follicular Lymphoma to Transformed Follicular Lymphoma
.
BLOOD
.
vol.
120
,
Wrench D, Leighton P, Skibola CF, Conde L, Cazier J-B, Matthews J, Iqbal S, Carlotti E et al.
(
2011
)
.
SNP rs6457327 in the HLA region on chromosome 6p is predictive of the transformation of follicular lymphoma
.
Blood
vol.
117
,
(
11
)
3147
-
3150
.
Wrench D, Sangaralingam A, Tayyib H, Kang MK, Riain C, Gupta M, Carlotti E, Bodor C et al.
(
2010
)
.
TNERSF14 and EZH2 Mutations, Chr2p Gain and Copy Number Changes Targeting Genes Whose Proteins Interact with the Microenviroment In Transformed Follicular Lymphoma
.
BLOOD
.
Conference:
52nd Annual Meeting of the American-Society-of-Hematology (ASH)
(
Orlando, FL
)
from:
04/12/2010
to:
07/12/2010
,
vol.
116
,
349
-
349
.
Wrench D, Sangaralingam A, Tayyib H, Kang MK, Riain C, Gupta M, Carlotti E, Bodor C et al.
(
2010
)
.
TNFRSF14 and EZH2 Mutations, Chr2p Gain and Copy Number Changes Targeting Genes Whose Proteins Interact with the Microenvironment In Transformed Follicular Lymphoma
.
BLOOD
.
vol.
116
,
349
-
349
.
Wrench J, Skibola C, Matthews J, Cazier JB, Iqbal S, Carlotti E, Calaminici M, Davies A et al.
(
2010
)
.
SNP RS6457327 ON CHROMOSOME 6P PREDICTS TRANSFORMATION OF FOLLICULAR LYMPHOMA
.
HAEMATOLOGICA
.
vol.
95
,
170
-
171
.
Wrench J, Skibola C, Matthews J, Cazier JB, Iqbal S, Carlotti E, Calaminici M, Davies A et al.
(
2010
)
.
SNP RS6457327 ON CHROMOSOME 6P PREDICTS TRANSFORMATION OF FOLLICULAR LYMPHOMA
.
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
.
vol.
95
,
170
-
171
.
Carlotti E, Gribben JG
(
2009
)
.
Stem cell mimicry: key to transformation?
.
Blood
vol.
114
,
(
15
)
3133
-
3134
.
Carlotti E, Wrench D, Matthews J, Iqbal S, Davies A, Norton A, Hart J, Lai R et al.
(
2009
)
.
Transformation of follicular lymphoma to diffuse large B-cell lymphoma may occur by divergent evolution from a common progenitor cell or by direct evolution from the follicular lymphoma clone
.
Blood
vol.
113
,
(
15
)
3553
-
3557
.
Wrench D, Waters R, Carlotti E, Iqbal S, Matthews J, Calaminici M, Gribben J, Lister TA et al.
(
2009
)
.
Clinical relevance of MDM2 SNP 309 and TP53 Arg72Pro in follicular lymphoma
.
Haematologica
vol.
94
,
(
1
)
148
-
150
.
O'Shea D, O'Riain C, Taylor C, Waters R, Carlotti E, MacDougall F, Gribben J, Rosenwald A et al.
(
2008
)
.
The presence of TP53 mutation at diagnosis of follicular lymphoma identifies a high-risk group of patients with shortened time to disease progression and poorer overall survival
.
BLOOD
vol.
112
,
(
8
)
3126
-
3129
.
Wrench D, Waters R, Matthews J, Calaminici M, Carlotti E, Iqbal S, Gribben J, Lister A et al.
(
2008
)
.
MDM2 309 and TP53 ARG72PRO SNP genotypes do not predict clinical outcome of follicular lymphoma
.
ANNALS OF ONCOLOGY
.
vol.
19
,
178
-
178
.
Pulsoni A, Della Starza I, Frattarelli N, Carlotti E, Cavalieri E, Ghia E, Matturro A, De Angelis F et al.
(
2008
)
.
PCR for BCL-2/IGH+ cells in stage I/II follicular lymphoma identifies positive cells in bone marrow and peripheral blood of the majority of patients, that can be cleared by lymph node irradiation
.
ANNALS OF ONCOLOGY
.
vol.
19
,
179
-
179
.
O'Shea D, O'Riain C, Taylor C, Waters R, Carlotti E, MacDougall F, Gribben J, Rosenwald A et al.
(
2008
)
.
TP53 MUTATION IDENTIFIES A HIGH RISK GROUP OF PATIENTS AT DIAGNOSIS OF FOLLICULAR LYMPHOMA AND IS ASSOCIATED WITH SHORTER TIME TO DISEASE PROGRESSION AND OVERALL SURVIVAL
.
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
.
vol.
93
,
356
-
356
.
Pulsoni A, Starza ID, Frattarelli N, Carlotti E, Cavalieri E, Matturro A, De Angelis F, Armiento D et al.
(
2008
)
.
Use of PCR for BCL2/IgH + cells in stage I/II follicular lymphoma to identify positive cells in bone marrow and peripheral blood that can be cleared by lymph-node irradiation
.
Journal of Clinical Oncology
.
vol.
26
,
8571
-
8571
.
Carlotti E, Wrench D, Iqbal S, O’Shea D, Davies A, Virappane P, Hart J, Lai R et al.
(
2007
)
.
Determining the Mechanism of Transformation of Follicular Lymphoma into Diffuse Large B Cell Lymphoma
.
Blood
vol.
110
,
(
11
)
181
-
181
.
Carlotti E, Wrench D, Iqbal S, O'Shea D, Davies A, Virappane P, Hart J, Lai R et al.
(
2007
)
.
Determining the mechanism of transformation of follicular lymphoma into diffuse large B cell lymphoma
.
BLOOD
.
vol.
110
,
61A
-
61A
.
Carlotti E, Salmoiraghi S, Palumbo GA, Oldani E, Tibullo D, Rossi A, Golay J, Pulsoni A et al.
(
2007
)
.
Fc alpha RIIIA and Fc Gamma RIIA polymorphisms do not predict the clinical outcome of follicular non Hodgkin's lymphoma patients treated with sequential CHOP and Rituximab
.
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
.
vol.
92
,
49
-
49
.
Carlotti E, Palumbo GA, Oldani E, Tibullo D, Salmoiraghi S, Rossi A, Golay J, Pulsoni A et al.
(
2007
)
.
FcgammaRIIIA and FcgammaRIIA polymorphisms do not predict clinical outcome of follicular non-Hodgkin's lymphoma patients treated with sequential CHOP and rituximab
.
Haematologica
vol.
92
,
(
8
)
1127
-
1130
.
Fitzgibbon J, Iqbal S, Davies A, O'shea D, Carlotti E, Chaplin T, Matthews J, Raghavan M et al.
(
2007
)
.
Genome-wide detection of recurring sites of uniparental disomy in follicular and transformed follicular lymphoma
.
Leukemia
vol.
21
,
(
7
)
1514
-
1520
.
Pulsoni A, Della Starza I, Frattarelli N, Ghia E, Carlotti E, Cavalieri E, Matturro A, Tempera S et al.
(
2007
)
.
Localized follicular lymphoma: Spread of BCL-2/IgH+ cells in the blood and bone marrow from the primary site of disease and possibility of clearance after involved field radiotherapy
.
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
.
vol.
92
,
103
-
103
.
O'Shea D, Iqbal S, Carlotti E, Davies A, Chaplin T, Matthews J, Manoj M, Norton A et al.
(
2007
)
.
SNP array profiling of follicular lymphoma reveals novel regions of acquired UPD
.
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
.
vol.
92
,
62
-
62
.
Pulsoni A, Della Starza I, Frattarelli N, Ghia E, Carlotti E, Cavalieri E, Matturro A, Tempera S et al.
(
2007
)
.
Stage I/II follicular lymphoma: spread of bcl-2/IgH+ cells in blood and bone marrow from primary site of disease and possibility of clearance after involved field radiotherapy
.
BRIT J HAEMATOL
vol.
137
,
(
3
)
216
-
220
.
O'Shea D, Iqbal S, Carlotti E, Davies A, Chaplin T, Matthews J, Raghavan M, Norton A et al.
(
2006
)
.
aUPD in the clonal evolution of follicular lymphoma
.
BLOOD
.
vol.
108
,
585A
-
585A
.
Carlotti E, Palumbo GA, Oldani E, Acerboni S, Di Raimondo F, Cortelazzo S, Pulsoni A, Barbui T et al.
(
2005
)
.
Bone Marrow BCL2/IgH+ Cells at Diagnosis and Not FCGRIIIA Polymorphism Predict Response in Follicular Non-Hodgkin’s Lymphoma Patients Treated with Sequential CHOP and Rituximab
.
Blood
vol.
106
,
(
11
)
985
-
985
.
Carlotti E, Palumbo GA, Oldani E, Acerboni S, Di Raimondo F, Cortelazzo S, Pulsoni A, Barbui T et al.
(
2005
)
.
Bone marrow BCL2/IgH+ cells at diagnosis and not FCGRIIIA polymorphism predict response in follicular non-Hodgkin's lymphoma patients treated with sequential CHOP and rituximab
.
BLOOD
.
vol.
106
,
289A
-
290A
.
Cortelazzo S, Rossi A, Carlotti E, Viero P, Rambaldi A, Barbui T
(
2005
)
.
The addition of Rituximab to high dose sequential chemotherapy (HDS) programs with autologous transplantation significantly improves the outcome of patients with refractory or relapsed B-cell non Hogkin's lymphoma
.
BLOOD
.
vol.
106
,
589A
-
590A
.
Rambaldi A, Carlotti E, Oldani E, Della Starza I, Baccarani M, Cortelazzo S, Lauria F, Arcaini L et al.
(
2005
)
.
Quantitative PCR of bone marrow BCL2/IgH+ cells at diagnosis predicts treatment response and long-term outcome in follicular non-Hodgkin lymphoma
.
Blood
vol.
105
,
(
9
)
3428
-
3433
.
Rambaldi A, Carlotti E, Baccarani M, Barbui T, Lauria F, Lazzarino M, Mandelli F, Morra E et al.
(
2003
)
.
Long term improvement of clinical outcome of follicular lymphoma patients achieving a molecular response after sequential CHOP and rituximab treatment: Predictive value of real time quantitative PCR to identify responding patients
.
BLOOD
.
vol.
102
,
409A
-
409A
.
Carlotti E, Pettenella F, Amaru R, Slater S, Lister TA, Barbui T, Basso G, Cazzaniga G et al.
(
2002
)
.
Molecular characterization of a new recombination of the SIL/TAL-1 locus in a child with T-cell acute lymphoblastic leukaemia
.
BRIT J HAEMATOL
vol.
118
,
(
4
)
1011
-
1018
.
Rambaldi A, Lazzari M, Manzoni C, Carlotti E, Arcaini L, Baccarani M, Barbui T, Bernasconi C et al.
(
2002
)
.
Monitoring of minimal residual disease after CHOP and rituximab in previously untreated patients with follicular lymphoma
.
BLOOD
vol.
99
,
(
3
)
856
-
862
.
Rambaldi A, Carlotti E, Baccarani M, Barbui T, Dastoli G, Lauria F, Lazzarino M, Mandelli F et al.
(
2001
)
.
Monitoring of minimal residual disease after CHOP and Rituximab in previously untreated follicular lymphoma patients
.
BLOOD
vol.
98
,
(
11
)
603A
-
603A
.