Publications: Prosir Mark Caulfield

Magavern EF, Kapil V, Saxena M, Gupta A, Caulfield MJ ( 2024 ) . Use of Genomics to Develop Novel Therapeutics and Personalize Hypertension Therapy . Arteriosclerosis Thrombosis and Vascular Biology

Collier DJ, Taylor M, Godec T, Shiel J, James R, Chowdury Y, Ebano P, Monk V et al. ( 2024 ) . Personalized Antihypertensive Treatment Optimization With Smartphone-Enabled Remote Precision Dosing of Amlodipine During the COVID-19 Pandemic (PERSONAL-CovidBP Trial) . Journal of the American Heart Association vol. 13 , ( 4 )

Sosinsky A, Ambrose J, Cross W, Turnbull C, Henderson S, Jones L, Hamblin A, Arumugam P et al. ( 2024 ) . Insights for precision oncology from the integration of genomic and clinical data of 13,880 tumors from the 100,000 Genomes Cancer Programme . Nature Medicine vol. 30 , ( 1 ) 279 - 289 .

Magavern EF, Jacobs B, Warren H, Finocchiaro G, Finer S, Van Heel DA, Smedley D, Caulfield MJ ( 2023 ) . CYP2C19 genotype prevalence and association with recurrent myocardial infarction in British-South Asians treated with clopidogrel . European Heart Journal vol. 44 , ( Supplement_2 )

Magavern EF, Van Heel DA, Smedley D, Caulfield MJ ( 2023 ) . SLCO1B1*5 is protective against non-senile cataracts in cohort prescribed statins: analysis in a British-South Asian cohort . European Heart Journal vol. 44 , ( Supplement_2 )

Magavern EF, Hitchings A, Bollington L, Wilson K, Hepburn D, Westacott RJ, Sam AH, Caulfield MJ et al. ( 2023 ) . UK Prescribing Safety Assessment (PSA): The development, implementation and outcomes of a national online prescribing assessment . British Journal of Clinical Pharmacology vol. 90 , ( 2 ) 493 - 503 .

Jeffries L, Mis EK, McWalter K, Donkervoort S, Brodsky NN, Carpier J-M, Ji W, Ionita C et al. ( 2023 ) . Biallelic CRELD1 variants cause a multisystem syndrome, including neurodevelopmental phenotypes, cardiac dysrhythmias, and frequent infections . Genetics in Medicine vol. 26 , ( 2 )

Magavern EF, Durrani F, Raza M, Lerner R, Islam MR, Clinch M, Caulfield MJ ( 2023 ) . British South Asian ancestry participants views of pharmacogenomics clinical implementation and research: a thematic analysis . The Pharmacogenomics Journal vol. 23 , ( 6 ) 185 - 194 .

Hartmann S, Yasmeen S, Jacobs BM, Denaxas S, Pirmohamed M, Gamazon ER, Caulfield MJ, Hemingway H et al. ( 2023 ) . ADRA2A and IRX1 are putative risk genes for Raynaud’s phenomenon . Nature Communications vol. 14 , ( 1 )

Xiao S, Kai Z, Murphy D, Li D, Patel D, Bielowka AM, Bernabeu-Herrero ME, Abdulmogith A et al. ( 2023 ) . Functional filter for whole-genome sequencing data identifies HHT and stress-associated non-coding SMAD4 polyadenylation site variants >5 kb from coding DNA . American Journal of Human Genetics vol. 110 , ( 11 ) 1903 - 1918 .

Kovilakam SC, Gu M, Dunn WG, Marando L, Barcena C, Consortium GER, Ambrose JC, Arumugam P et al. ( 2023 ) . Prevalence and significance of DDX41 gene variants in the general population . Blood vol. 142 , ( 14 ) 1185 - 1192 .

Lagou V, Jiang L, Ulrich A, Zudina L, González KSG, Balkhiyarova Z, Faggian A, Maina JG et al. ( 2023 ) . GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification . Nature Genetics vol. 55 , ( 9 ) 1448 - 1461 .

Magavern EF, Jacobs B, Warren H, Finocchiaro G, Finer S, van Heel DA, Team GHR, Smedley D et al. ( 2023 ) . CYP2C19 Genotype Prevalence and Association With Recurrent Myocardial Infarction in British–South Asians Treated With Clopidogrel . JACC Advances vol. 2 , ( 7 )

Magavern EF, Team GHR, Smedley D, Caulfield MJ ( 2023 ) . Factor V Leiden, estrogen, and multimorbidity association with venous thromboembolism in a British-South Asian cohort . iScience vol. 26 , ( 10 )

Hayward S, Norton J, Bownass L, Platt C, Campbell H, Watson E, Forrester N, Smithson S et al. ( 2023 ) . A novel likely pathogenic CLCN5 variant in Dent’s disease . BMC Nephrology vol. 24 , ( 1 )

Claus LR, Chen C, Stallworth J, Turner JL, Slaats GG, Hawks AL, Mabillard H, Senum SR et al. ( 2023 ) . Certain heterozygous variants in the kinase domain of the serine/threonine kinase NEK8 can cause an autosomal dominant form of polycystic kidney disease . Kidney International vol. 104 , ( 5 ) 995 - 1007 .

Magavern EF, Heel DA, Team GHR, Smedley D, Caulfield MJ ( 2023 ) . CYP2C19 loss‐of‐function alleles are not associated with higher prevalence of gastrointestinal bleeds in those who have been prescribed antidepressants: Analysis in a British‐South Asian cohort . British Journal of Clinical Pharmacology vol. 89 , ( 11 ) 3432 - 3438 .

Niggl E, Bouman A, Briere LC, Hoogenboezem RM, Wallaard I, Park J, Admard J, Wilke M et al. ( 2023 ) . HNRNPC haploinsufficiency affects alternative splicing of intellectual disability-associated genes and causes a neurodevelopmental disorder . American Journal of Human Genetics vol. 110 , ( 8 ) 1414 - 1435 .

Akinrinade O, Lesurf R, Lougheed J, Mondal T, Smythe J, Altamirano-Diaz L, Oechslin E, Mital S ( 2023 ) . Age and Sex Differences in the Genetics of Cardiomyopathy . Journal of Cardiovascular Translational Research vol. 16 , ( 6 ) 1287 - 1302 .

Dominik N, Magri S, Currò R, Abati E, Facchini S, Corbetta M, Macpherson H, Di Bella D et al. ( 2023 ) . Normal and pathogenic variation of RFC1 repeat expansions: implications for clinical diagnosis . Brain vol. 146 , ( 12 ) 5060 - 5069 .

Gracia-Diaz C, Zhou Y, Yang Q, Maroofian R, Espana-Bonilla P, Lee C-H, Zhang S, Padilla N et al. ( 2023 ) . Gain and loss of function variants in EZH1 disrupt neurogenesis and cause dominant and recessive neurodevelopmental disorders . Nature Communications vol. 14 , ( 1 )

Sanjaya P, Maljanen K, Katainen R, Waszak SM, Aaltonen LA, Stegle O, Korbel JO, Pitkänen E ( 2023 ) . Mutation-Attention (MuAt): deep representation learning of somatic mutations for tumour typing and subtyping . Genome Medicine vol. 15 , ( 1 )

Vetro A, Pelorosso C, Balestrini S, Masi A, Hambleton S, Argilli E, Conti V, Giubbolini S et al. ( 2023 ) . Stretch-activated ion channel TMEM63B associates with developmental and epileptic encephalopathies and progressive neurodegeneration . American Journal of Human Genetics vol. 110 , ( 8 ) 1356 - 1376 .

Sadeghi-Alavijeh O, Chan MMY, Moochhala SH, Consortium GER, Ambrose JC, Arumugam P, Bevers R, Bleda M et al. ( 2023 ) . Rare variants in the sodium-dependent phosphate transporter gene SLC34A3 explain missing heritability of urinary stone disease . Kidney International vol. 104 , ( 5 ) 975 - 984 .

Leggatt G, Cheng G, Narain S, Briseño-Roa L, Annereau J-P, Gast C, Gilbert RD, Ennis S ( 2023 ) . A genotype-to-phenotype approach suggests under-reporting of single nucleotide variants in nephrocystin-1 (NPHP1) related disease (UK 100,000 Genomes Project) . Scientific Reports vol. 13 , ( 1 )

Tesi B, Boileau C, Boycott KM, Canaud G, Caulfield M, Choukair D, Hill S, Spielmann M et al. ( 2023 ) . Precision medicine in rare diseases: What is next? . Journal of Internal Medicine vol. 294 , ( 4 ) 397 - 412 .

Graham SE, Clarke SL, Wu K-HH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I et al. ( 2023 ) . Author Correction: The power of genetic diversity in genome-wide association studies of lipids . Nature vol. 618 , ( 7965 ) e19 - e20 .

Magavern EF, van Heel DA, Smedley D, Caulfield MJ ( 2023 ) . SLCO1B1*5 is protective against non-senile cataracts in cohort prescribed statins: analysis in a British-South Asian cohort . The Pharmacogenomics Journal vol. 23 , ( 5 ) 134 - 139 .

Choi D-J, Armstrong G, Lozzi B, Vijayaraghavan P, Plon SE, Wong TC, Boerwinkle E, Muzny DM et al. ( 2023 ) . The genomic landscape of familial glioma . Science Advances vol. 9 , ( 17 )

Martins Custodio H, Clayton LM, Bellampalli R, Pagni S, Silvennoinen K, Caswell R, Ambrose JC, Arumugam P et al. ( 2023 ) . Widespread genomic influences on phenotype in Dravet syndrome, a ‘monogenic’ condition . Brain vol. 146 , ( 9 ) 3885 - 3897 .

Siedlinski M, Carnevale L, Xu X, Carnevale D, Evangelou E, Caulfield MJ, Maffia P, Wardlaw J et al. ( 2023 ) . Genetic analyses identify brain structures related to cognitive impairment associated with elevated blood pressure . European Heart Journal vol. 44 , ( 23 ) 2114 - 2125 .

Jackson A, Lin S-J, Jones EA, Chandler KE, Orr D, Moss C, Haider Z, Ryan G et al. ( 2023 ) . Clinical, genetic, epidemiologic, evolutionary, and functional delineation of TSPEAR-related autosomal recessive ectodermal dysplasia 14 . Human Genetics and Genomics Advances vol. 4 , ( 2 )

Magavern EF, Caulfield MJ ( 2023 ) . Equal access to pharmacogenomics testing: The ethical imperative for population‐wide access in the UK NHS . British Journal of Clinical Pharmacology vol. 89 , ( 5 ) 1701 - 1703 .

Magavern E, Smedley D, Caulfield M ( 2023 ) . Factor V Leiden and oestrogen use in the context of multiple common chronic medical conditions: Analysis in the Genes & Health British-South Asian Cohort . BRITISH JOURNAL OF PHARMACOLOGY . vol. 180 , 368 - 371 .

Magavern E, van Heel D, Smedley D, Caulfield M ( 2023 ) . Precision prescribing would not reduce gastrointestinal bleeds associated with CYP2C19 metabolized antidepressants:: Analysis in a British-South Asian cohort . BRITISH JOURNAL OF PHARMACOLOGY . vol. 180 , 365 - 368 .

Kanoni S, Graham SE, Wang Y, Surakka I, Ramdas S, Zhu X, Clarke SL, Bhatti KF et al. ( 2022 ) . Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis . Genome Biology vol. 23 , ( 1 )

Seaby EG, Thomas NS, Webb A, Brittain H, Taylor Tavares AL, Baralle D, Rehm HL, O’Donnell-Luria A et al. ( 2022 ) . Targeting de novo loss-of-function variants in constrained disease genes improves diagnostic rates in the 100,000 Genomes Project . Human Genetics vol. 142 , ( 3 ) 351 - 362 .

Macken WL, Falabella M, McKittrick C, Pizzamiglio C, Ellmers R, Eggleton K, Woodward CE, Patel Y et al. ( 2022 ) . Specialist multidisciplinary input maximises rare disease diagnoses from whole genome sequencing . Nature Communications vol. 13 , ( 1 )

Robbe P, Ridout KE, Vavoulis DV, Dréau H, Kinnersley B, Denny N, Chubb D, Appleby N et al. ( 2022 ) . Whole-genome sequencing of chronic lymphocytic leukemia identifies subgroups with distinct biological and clinical features . Nature Genetics vol. 54 , ( 11 ) 1675 - 1689 .

Cacheiro P, Westerberg CH, Mager J, Dickinson ME, Nutter LMJ, Muñoz-Fuentes V, Hsu C-W, Van den Veyver IB et al. ( 2022 ) . Mendelian gene identification through mouse embryo viability screening . Genome Medicine vol. 14 , ( 1 )

Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen AU et al. ( 2022 ) . A saturated map of common genetic variants associated with human height . Nature vol. 610 , ( 7933 ) 704 - 712 .

Wei W, Schon KR, Elgar G, Orioli A, Tanguy M, Giess A, Tischkowitz M, Caulfield MJ et al. ( 2022 ) . Nuclear-embedded mitochondrial DNA sequences in 66,083 human genomes . Nature vol. 611 , ( 7934 ) 105 - 114 .

Moreno-Ruiz N, Lao O, Aróstegui JI, Laayouni H, Casals F ( 2022 ) . Assessing the digenic model in rare disorders using population sequencing data . European Journal of Human Genetics vol. 30 , ( 12 ) 1439 - 1443 .

( 2022 ) . Corrigendum to: The role of pharmacogenomics in contemporary cardiovascular therapy: a position statement from the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy . European Heart Journal - Cardiovascular Pharmacotherapy vol. 9 , ( 1 ) 116 - 116 .

Chan MM, Sadeghi-Alavijeh O, Lopes FM, Hilger AC, Stanescu HC, Voinescu CD, Beaman GM, Newman WG et al. ( 2022 ) . Diverse ancestry whole-genome sequencing association study identifies TBX5 and PTK7 as susceptibility genes for posterior urethral valves . eLife vol. 11 ,

Nguyen H, Solomonson M, Palotie A, Davis L, Lee S, Priest J, Sankaran VG, van Heel D et al. ( 2022 ) . A first update on mapping the human genetic architecture of COVID-19 . Nature vol. 608 , ( 7921 ) e1 - e10 .

Ramdas S, Judd J, Graham SE, Kanoni S, Wang Y, Surakka I, Wenz B, Clarke SL et al. ( 2022 ) . A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids . American Journal of Human Genetics vol. 109 , ( 8 ) 1366 - 1387 .

Joyce KE, Onabanjo E, Brownlow S, Nur F, Olupona K, Fakayode K, Sroya M, Thomas GA et al. ( 2022 ) . Whole genome sequences discriminate hereditary hemorrhagic telangiectasia phenotypes by non-HHT deleterious DNA variation . Blood Advances vol. 6 , ( 13 ) 3956 - 3969 .

Gibson JT, Sadeghi-Alavijeh O, Gale DP, Rothe H, Savige J ( 2022 ) . Pathogenicity of missense variants affecting the collagen IV α5 carboxy non-collagenous domain in X-linked Alport syndrome . Scientific Reports vol. 12 , ( 1 )

Shoemark A, Griffin H, Wheway G, Hogg C, Lucas JS, Camps C, Taylor J, Carroll M et al. ( 2022 ) . Genome sequencing reveals underdiagnosis of primary ciliary dyskinesia in bronchiectasis . European Respiratory Journal vol. 60 , ( 5 )

Trotman J, Armstrong R, Firth H, Trayers C, Watkins J, Allinson K, Jacques TS, Nicholson JC et al. ( 2022 ) . The NHS England 100,000 Genomes Project: feasibility and utility of centralised genome sequencing for children with cancer . British Journal of Cancer vol. 127 , ( 1 ) 137 - 144 .

Calabrese C, Pyle A, Griffin H, Coxhead J, Hussain R, Braund PS, Li L, Burgess A et al. ( 2022 ) . Heteroplasmic mitochondrial DNA variants in cardiovascular diseases . PLOS Genetics vol. 18 , ( 4 )

Al-Jawahiri R, Foroutan A, Kerkhof J, McConkey H, Levy M, Haghshenas S, Rooney K, Turner J et al. ( 2022 ) . SOX11 variants cause a neurodevelopmental disorder with infrequent ocular malformations and hypogonadotropic hypogonadism and with distinct DNA methylation profile . Genetics in Medicine vol. 24 , ( 6 ) 1261 - 1273 .

Lesurf R, Said A, Akinrinade O, Breckpot J, Delfosse K, Liu T, Yao R, Persad G et al. ( 2022 ) . Whole genome sequencing delineates regulatory, copy number, and cryptic splice variants in early onset cardiomyopathy . npj Genomic Medicine vol. 7 , ( 1 )

Baillie JK, Begg C, Clohisey Hendry S, Hinds C, Horby P, Knight J, Ling L, Maslove D et al. ( 2022 ) . Whole-genome sequencing reveals host factors underlying critical COVID-19 . Nature vol. 607 , ( 7917 ) 97 - 103 .

Ibañez K, Polke J, Hagelstrom RT, Dolzhenko E, Pasko D, Thomas ERA, Daugherty LC, Kasperaviciute D et al. ( 2022 ) . Whole genome sequencing for the diagnosis of neurological repeat expansion disorders in the UK: a retrospective diagnostic accuracy and prospective clinical validation study . The Lancet Neurology vol. 21 , ( 3 ) 234 - 245 .

Reijns MAM, Parry DA, Williams TC, Nadeu F, Hindshaw RL, Rios Szwed DO, Nicholson MD, Carroll P et al. ( 2022 ) . Signatures of TOP1 transcription-associated mutagenesis in cancer and germline . Nature vol. 602 , ( 7898 ) 623 - 631 .

Horgan D, Borisch B, Cattaneo I, Caulfield M, Chiti A, Chomienne C, Cole A, Facey K et al. ( 2022 ) . Factors Affecting Citizen Trust and Public Engagement Relating to the Generation and Use of Real-World Evidence in Healthcare . International Journal of Environmental Research and Public Health vol. 19 , ( 3 )

Owen N, Toms M, Young RM, Eintracht J, Sarkar H, Brooks BP, Moosajee M, Consortium GER et al. ( 2022 ) . Identification of 4 novel human ocular coloboma genes ANK3, BMPR1B, PDGFRA, and CDH4 through evolutionary conserved vertebrate gene analysis . Genetics in Medicine vol. 24 , ( 5 ) 1073 - 1084 .

Trompet S, Postmus I, Warren HR, Noordam R, Smit RAJ, Theusch E, Li X, Arsenault B et al. ( 2022 ) . The Pharmacogenetics of Statin Therapy on Clinical Events: No Evidence that Genetic Variation Affects Statin Response on Myocardial Infarction . Frontiers in Pharmacology vol. 12 ,

McGuigan A, Whitworth J, Andreou A, Hearn T, Tischkowitz M, Maher ER ( 2022 ) . Multilocus Inherited Neoplasia Allele Syndrome (MINAS): an update . European Journal of Human Genetics vol. 30 , ( 3 ) 265 - 270 .

Tooze RS, Hyder Z, Calpena E, Pei Y, Twigg SRF, Cilliers D, Morton JEV, McCann E et al. ( 2022 ) . Evaluating the performance of a clinical genome sequencing programme for diagnosis of rare genetic disease, seen through the lens of craniosynostosis . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 30 , 51 - 52 .

Collier D, Taylor M, Godec T, Shiel J, James R, Chowdury Y, Ebano P, Monk V et al. ( 2022 ) . Personalized electronic record supported optimisation when alone for patients with hypertension- pilot study for remote medical management of hypertension during the Covid-19 pandemic (personal covidBP) . JOURNAL OF HUMAN HYPERTENSION . vol. 36 , 8 - 8 .

Balachandar S, Graves TJ, Shimonty A, Kerr K, Kilner J, Xiao S, Slade R, Sroya M et al. ( 2021 ) . Identification and validation of a novel pathogenic variant in GDF2 (BMP9) responsible for hereditary hemorrhagic telangiectasia and pulmonary arteriovenous malformations . American Journal of Medical Genetics Part A vol. 188 , ( 3 ) 959 - 964 .

Graham SE, Clarke SL, Wu K-HH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I et al. ( 2021 ) . The power of genetic diversity in genome-wide association studies of lipids . Nature vol. 600 , ( 7890 ) 675 - 679 .

Bacq A, Roussel D, Bonduelle T, Zagaglia S, Maletic M, Ribierre T, Adle‐Biassette H, Marchal C et al. ( 2021 ) . Cardiac Investigations in Sudden Unexpected Death in DEPDC5‐Related Epilepsy . Annals of Neurology vol. 91 , ( 1 ) 101 - 116 .

Pagnamenta AT, Diaz-Gonzalez F, Banos-Pinero B, Ferla MP, Toosi MB, Calder AD, Karimiani EG, Doosti M et al. ( 2021 ) . Variable skeletal phenotypes associated with biallelic variants in PRKG2 . Journal of Medical Genetics vol. 59 , ( 10 ) 947 - 950 .

Smedley D, Smith KR, Martin AR, Thomas EA, McDonagh EM, Cipriani V, Ellingford JM, Arno G et al. ( 2021 ) . 100,000 Genomes Pilot on Rare-Disease Diagnosis in Health Care — Preliminary Report . New England Journal of Medicine vol. 385 , ( 20 ) 1868 - 1880 .

Schon KR, Horvath R, Wei W, Calabrese C, Tucci A, Ibañez K, Ratnaike T, Pitceathly RDS et al. ( 2021 ) . Use of whole genome sequencing to determine genetic basis of suspected mitochondrial disorders: cohort study . The BMJ vol. 375 ,

Best S, Lord J, Roche M, Watson CM, Poulter JA, Bevers RPJ, Stuckey A, Szymanska K et al. ( 2021 ) . Molecular diagnoses in the congenital malformations caused by ciliopathies cohort of the 100,000 Genomes Project . Journal of Medical Genetics vol. 59 , ( 8 ) 737 - 747 .

Rowlands C, Thomas HB, Lord J, Wai HA, Arno G, Beaman G, Sergouniotis P, Gomes-Silva B et al. ( 2021 ) . Comparison of in silico strategies to prioritize rare genomic variants impacting RNA splicing for the diagnosis of genomic disorders . Scientific Reports vol. 11 , ( 1 )

Wei Y, Papachristou N, Mueller S, Chang WH, Lai AG ( 2021 ) . Application of ensemble clustering and survival tree analysis for identifying prognostic clinicogenomic features in patients with colorectal cancer from the 100,000 Genomes Project . BMC Research Notes vol. 14 , ( 1 )

Magavern EF, Kaski JC, Turner RM, Drexel H, Janmohamed A, Scourfield A, Burrage D, Floyd CN et al. ( 2021 ) . Challenges in cardiovascular pharmacogenomics implementation: a viewpoint from the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy . European Heart Journal - Cardiovascular Pharmacotherapy vol. 8 , ( 1 ) 100 - 103 .

Silvennoinen K, Puvirajasinghe C, Hudgell K, Sidhu MK, Custodio HM, Ambrose JC, Arumugam P, Baple EL et al. ( 2021 ) . Late diagnoses of Dravet syndrome: How many individuals are we missing? . Epilepsia Open vol. 6 , ( 4 ) 770 - 776 .

Stark Z, Foulger RE, Williams E, Thompson BA, Patel C, Lunke S, Snow C, Leong IUS et al. ( 2021 ) . Scaling national and international improvement in virtual gene panel curation via a collaborative approach to discordance resolution . American Journal of Human Genetics vol. 108 , ( 9 ) 1551 - 1557 .

Iqbal M, Maroofian R, Çavdarlı B, Riccardi F, Field M, Banka S, Bubshait DK, Li Y et al. ( 2021 ) . Biallelic variants in PCDHGC4 cause a novel neurodevelopmental syndrome with progressive microcephaly, seizures, and joint anomalies . Genetics in Medicine vol. 23 , ( 11 ) 2138 - 2149 .

Niemi MEK, Karjalainen J, Liao RG, Neale BM, Daly M, Ganna A, Davis L, Lee S et al. ( 2021 ) . Mapping the human genetic architecture of COVID-19 . Nature vol. 600 , ( 7889 ) 472 - 477 .

Lin S-J, Vona B, Barbalho PG, Kaiyrzhanov R, Maroofian R, Petree C, Severino M, Stanley V et al. ( 2021 ) . Biallelic variants in KARS1 are associated with neurodevelopmental disorders and hearing loss recapitulated by the knockout zebrafish . Genetics in Medicine vol. 23 , ( 10 ) 1933 - 1943 .

Kosmicki JA, Horowitz JE, Banerjee N, Lanche R, Marcketta A, Maxwell E, Bai X, Sun D et al. ( 2021 ) . Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals . American Journal of Human Genetics vol. 108 , ( 7 ) 1350 - 1355 .

Chen J, Spracklen CN, Marenne G, Varshney A, Corbin LJ, Luan J, Willems SM, Wu Y et al. ( 2021 ) . The trans-ancestral genomic architecture of glycemic traits . Nature Genetics vol. 53 , ( 6 ) 840 - 860 .

Eales JM, Jiang X, Xu X, Saluja S, Akbarov A, Cano-Gamez E, McNulty MT, Finan C et al. ( 2021 ) . Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney . Nature Genetics vol. 53 , ( 5 ) 630 - 637 .

Zenner D ( 2021 ) . The Barts Health NHS Trust COVID-19 cohort: characteristics, outcomes and risk scoring of patients in East London . International Journal of Tuberculosis and Lung Disease

Warren H, Garofalidou T, Singh S, Melander O, Hiltunen T, Glorioso N, Cooper-Dehoff R, Dominiczak A et al. ( 2021 ) . GENOME-WIDE ASSOCIATION STUDY FOR PHARMACOGENETIC RESPONSE OF BLOOD PRESURE TO BETA BLOCKER AND CALCIUM CHANNEL BLOCKER DRUGS . Journal of Hypertension vol. 39 , ( Supplement 1 ) e258 - e259 .

Warren H, Traylor M, Garofalidou T, Ng FL, Gupta A, Sever P, Caulfield M, Munroe P ( 2021 ) . HYPERTENSIVE PATIENTS WITH GREATER GENETIC RISK RESPOND LESS EFFECTIVELY TO TREATMENT AND ARE MORE LIKELY TO BE TREATMENT RESISTANT . Journal of Hypertension vol. 39 , ( Supplement 1 )

Magavern EF, Kaski JC, Turner RM, Drexel H, Janmohamed A, Scourfield A, Burrage D, Floyd CN et al. ( 2021 ) . The role of pharmacogenomics in contemporary cardiovascular therapy: a position statement from the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy . European Heart Journal - Cardiovascular Pharmacotherapy vol. 8 , ( 1 ) 85 - 99 .

Jones CL, Degasperi A, Grandi V, Amarante TD, Mitchell TJ, Nik-Zainal S, Whittaker SJ ( 2021 ) . Spectrum of mutational signatures in T-cell lymphoma reveals a key role for UV radiation in cutaneous T-cell lymphoma . Scientific Reports vol. 11 , ( 1 )

Ragoussis V, Pagnamenta AT, Haines RL, Giacopuzzi E, McClatchey MA, Sampson JR, Suri M, Gardham A et al. ( 2021 ) . Using data from the 100,000 Genomes Project to resolve conflicting interpretations of a recurrent TUBB2A mutation . Journal of Medical Genetics vol. 59 , ( 4 ) 366 - 369 .

Pagnamenta AT, Kaiyrzhanov R, Zou Y, Da'as SI, Maroofian R, Donkervoort S, Dominik N, Lauffer M et al. ( 2021 ) . An ancestral 10-bp repeat expansion in VWA1 causes recessive hereditary motor neuropathy . Brain

Magavern EF, Warren HR, Ng FL, Cabrera CP, Munroe PB, Caulfield MJ ( 2021 ) . An Academic Clinician’s Road Map to Hypertension Genomics . Hypertension vol. 77 , ( 2 ) 284 - 295 .

Bick D, Bick SL, Dimmock DP, Fowler TA, Caulfield MJ, Scott RH ( 2020 ) . An online compendium of treatable genetic disorders . American Journal of Medical Genetics Part C Seminars in Medical Genetics vol. 187 , ( 1 ) 48 - 54 .

Boguslavskyi A, Tokar S, Prysyazhna O, Rudyk O, Sanchez-Tatay D, Lemmey HAL, Dora KA, Garland CJ et al. ( 2020 ) . Phospholemman Phosphorylation Regulates Vascular Tone, Blood Pressure, and Hypertension in Mice and Humans . Circulation vol. 143 , ( 11 ) 1123 - 1138 .

Pairo-Castineira E, Clohisey S, Klaric L, Bretherick AD, Rawlik K, Pasko D, Walker S, Parkinson N et al. ( 2020 ) . Genetic mechanisms of critical illness in COVID-19 . Nature vol. 591 , ( 7848 ) 92 - 98 .

Poulter JA, Gravett MSC, Taylor RL, Fujinami K, De Zaeytijd J, Bellingham J, Rehman AU, Hayashi T et al. ( 2020 ) . New variants and in silico analyses in GRK1 associated Oguchi disease . Human Mutation vol. 42 , ( 2 ) 164 - 176 .

Steinthorsdottir V, McGinnis R, Williams NO, Stefansdottir L, Thorleifsson G, Shooter S, Fadista J, Sigurdsson JK et al. ( 2020 ) . Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women . Nature Communications vol. 11 , ( 1 )

Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B et al. ( 2020 ) . Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals . Nature Genetics vol. 52 , ( 12 ) 1314 - 1332 .

Turner RM, Newman WG, Bramon E, McNamee CJ, Wong WL, Misbah S, Hill S, Caulfield M et al. ( 2020 ) . Pharmacogenomics in the UK National Health Service: opportunities and challenges . Pharmacogenomics vol. 21 , ( 17 ) 1237 - 1246 .

Parry DA, Martin CA, Greene P, Marsh JA, Ambrose JC, Arumugam P, Baple EL, Bleda M et al. ( 2020 ) . Heterozygous lamin B1 and lamin B2 variants cause primary microcephaly and define a novel laminopathy . Genetics in Medicine

Gallo JE, Ochoa JE, Warren HR, Misas E, Correa MM, Gallo-Villegas JA, Bedoya G, Aristizábal D et al. ( 2020 ) . Hypertension and the roles of the 9p21.3 risk locus: Classic findings and new association data . International Journal of Cardiology Cardiovascular Risk and Prevention vol. 7 ,

Chen Z, Yan Yau W, Jaunmuktane Z, Tucci A, Sivakumar P, Gagliano Taliun SA, Turner C, Efthymiou S et al. ( 2020 ) . Neuronal intranuclear inclusion disease is genetically heterogeneous . Annals of Clinical and Translational Neurology Article acn3.51151 ,

Wei W, Pagnamenta AT, Gleadall N, Sanchis-Juan A, Stephens J, Broxholme J, Tuna S, Odhams CA et al. ( 2020 ) . Author Correction: Nuclear-mitochondrial DNA segments resemble paternally inherited mitochondrial DNA in humans . Nature Communications vol. 11 , ( 1 )

Turro E, Astle WJ, Megy K, Gräf S, Greene D, Shamardina O, Allen HL, Sanchis-Juan A et al. ( 2020 ) . Whole-genome sequencing of patients with rare diseases in a national health system . Nature vol. 583 , ( 7814 ) 96 - 102 .

Raisi-Estabragh Z, McCracken C, Bethell MS, Cooper J, Cooper C, Caulfield MJ, Munroe PB, Harvey NC et al. ( 2020 ) . Greater risk of severe COVID-19 in Black, Asian and Minority Ethnic populations is not explained by cardiometabolic, socioeconomic or behavioural factors, or by 25(OH)-vitamin D status: study of 1326 cases from the UK Biobank . Journal of Public Health vol. 42 , ( 3 )

Raisi-Estabragh Z, McCracken C, Bethell MS, Cooper J, Cooper C, Caulfield MJ, Munroe PB, Harvey NC et al. ( 2020 ) . Greater risk of severe COVID-19 in non-White ethnicities is not explained by cardiometabolic, socioeconomic, or behavioural factors, or by 25(OH)-vitamin D status: study of 1,326 cases from the UK Biobank .

Sackley CM, Rick C, Au P, Brady MC, Beaton G, Burton C, Caulfield M, Dickson S et al. ( 2020 ) . A multicentre, randomised controlled trial to compare the clinical and cost-effectiveness of Lee Silverman Voice Treatment versus standard NHS Speech and Language Therapy versus control in Parkinson’s disease: a study protocol for a randomised controlled trial . Trials vol. 21 , ( 1 )

Tolchin D, Yeager JP, Prasad P, Dorrani N, Russi AS, Martinez-Agosto JA, Haseeb A, Angelozzi M et al. ( 2020 ) . De Novo SOX6 Variants Cause a Neurodevelopmental Syndrome Associated with ADHD, Craniosynostosis, and Osteochondromas . American Journal of Human Genetics vol. 106 , ( 6 ) 830 - 845 .

Ntalla I, Weng L-C, Cartwright JH, Hall AW, Sveinbjornsson G, Tucker NR, Choi SH, Chaffin MD et al. ( 2020 ) . Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction . Nature Communications vol. 11 , ( 1 )

Wei W, Pagnamenta AT, Gleadall N, Sanchis-Juan A, Stephens J, Broxholme J, Tuna S, Odhams CA et al. ( 2020 ) . Nuclear-mitochondrial DNA segments resemble paternally inherited mitochondrial DNA in humans . Nature Communications vol. 11 , ( 1 )

Freeman TM, Wang D, Harris J, Ambrose JC, Arumugam P, Baple EL, Bleda M, Boardman-Pretty F et al. ( 2020 ) . Genomic loci susceptible to systematic sequencing bias in clinical whole genomes . Genome Research vol. 30 , ( 3 ) 415 - 426 .

Pleguezuelos-Manzano C, Puschhof J, Rosendahl Huber A, van Hoeck A, Wood HM, Nomburg J, Gurjao C, Manders F et al. ( 2020 ) . Mutational signature in colorectal cancer caused by genotoxic pks+E. coli . Nature vol. 580 , ( 7802 ) 269 - 273 .

Lloyd KCK, Adams DJ, Baynam G, Beaudet AL, Bosch F, Boycott KM, Braun RE, Caulfield M et al. ( 2020 ) . The Deep Genome Project . Genome Biology vol. 21 , ( 1 )

Cacheiro P, Muñoz-Fuentes V, Murray SA, Dickinson ME, Bucan M, Nutter LMJ, Peterson KA, Haselimashhadi H et al. ( 2020 ) . Human and mouse essentiality screens as a resource for disease gene discovery . Nature Communications vol. 11 , ( 1 )

Pu X, Chan K, Yang W, Xiao Q, Zhang L, Moore AD, Liu C, Webb TR et al. ( 2020 ) . Effect of a coronary-heart-disease-associated variant of ADAMTS7 on endothelial cell angiogenesis . Atherosclerosis vol. 296 , 11 - 17 .

Thomas ERA, Pasko D, Boustred C, Kasperaviciute D, Bleda M, Martin AR, Smedley D, McDonagh E et al. ( 2020 ) . Modelling diagnostic yield in the 100,000 Genomes Rare Disease Project using panel-based analysis and complementary approaches . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 28 , 639 - 640 .

Cabrera CP, Pazoki R, Giri A, Hellwege JN, Evangelou E, Ramirez J, Wain LV, Tzoulaki I et al. ( 2020 ) . Multi-trait genome-wide association analysis of blood pressure identifies 45 additional loci . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 28 , 105 - 105 .

Smedley D, Abbs S, Arno G, Baple E, Barnes M, Beales P, Bitner-Glindzicz M, Black G et al. ( 2020 ) . The impact of the 100,000 Genomes Project on rare disease in national healthcare . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 28 , 54 - 55 .

Kasperaviciute D, Smith KR, Ibanez K, Pasko D, Bleda M, Walker S, Polychronopoulos D, Martin AR et al. ( 2020 ) . Validation of Clinically Relevant Variant Detection from Whole Genome Sequencing for NHS England's Genomic Medicine Service . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 28 , 640 - 641 .

Caulfield M ( 2019 ) . 6 Translating genomics for clinical benefit . Postgraduate Medical Journal . vol. 95 , 686 - 686 .

Hong Y, Nanthapisal S, Omoyinmi E, Olbrich P, Neth O, Speckmann C, Lucena JM, Gilmour K et al. ( 2019 ) . Secondary C1q Deficiency in Activated PI3Kδ Syndrome Type 2 . Frontiers in Immunology vol. 10 ,

Martin AR, Williams E, Foulger RE, Leigh S, Daugherty LC, Niblock O, Leong IUS, Smith KR et al. ( 2019 ) . PanelApp crowdsources expert knowledge to establish consensus diagnostic gene panels . Nature Genetics vol. 51 , ( 11 ) 1560 - 1565 .

Clark DW, Okada Y, Moore KHS, Mason D, Pirastu N, Gandin I, Mattsson H, Barnes CLK et al. ( 2019 ) . Associations of autozygosity with a broad range of human phenotypes . Nature Communications vol. 10 , ( 1 ) 4957 - 4957 .

Smith KR, Bleda M, Kasperaviciute D, Ibanez K, Martin AR, Thomas E, Baple E, Tucci A et al. ( 2019 ) . Uniparental disomy in the Rare Disease Programme of the UK's 100,000 Genomes Project . EUROPEAN JOURNAL OF HUMAN GENETICS . Conference: European Society of Human Genetics vol. 27 , 1153 - 1154 .

Cabrera CP, Ng F, Nicholls HL, Gupta A, Barnes MR, Munroe PB, Caulfield MJ ( 2019 ) . Over 1000 genetic loci influencing blood pressure with multiple systems and tissues implicated . Human Molecular Genetics vol. 28 , ( R2 ) R151 - R161 .

Wheway G, Ambrose JC, Baple EL, Bleda M, Boardman-Pretty F, Boissiere JM, Boustred CR, Caulfield MJ et al. ( 2019 ) . Corrigendum: Opportunities and Challenges for Molecular Understanding of Ciliopathies–The 100,000 Genomes Project . Frontiers in Genetics vol. 10 ,

Scott RH, Fowler TA, Caulfield M ( 2019 ) . Genomic medicine: time for health-care transformation . The Lancet vol. 394 , ( 10197 ) 454 - 456 .

Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T et al. ( 2019 ) . Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity . Nature Genetics vol. 51 , ( 7 ) 1191 - 1192 .

Noordam R, Young WJ, Salman R, Kanters JK, van den Berg ME, van Heemst D, Lin HJ, Barreto SM et al. ( 2019 ) . Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals . Journal of the American College of Cardiology vol. 73 , ( 24 ) 3118 - 3131 .

Wei W, Tuna S, Keogh MJ, Smith KR, Aitman TJ, Beales PL, Bennett DL, Gale DP et al. ( 2019 ) . Germline selection shapes human mitochondrial DNA diversity . Science vol. 364 , ( 6442 )

Marques P, Tufton N, Bhattacharya S, Caulfield M, Akker SA ( 2019 ) . Hypertension due to a deoxycorticosterone-secreting adrenal tumour diagnosed during pregnancy . Endocrinology Diabetes and Metabolism Case Reports vol. 2019 , ( 1 ) 18 - 0164 .

Gorman KM, Meyer E, Grozeva D, Spinelli E, McTague A, Sanchis-Juan A, Carss KJ, Bryant E et al. ( 2019 ) . Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia . American Journal of Human Genetics vol. 104 , ( 5 ) 948 - 956 .

Sung YJ, de Las Fuentes L, Winkler TW, Chasman DI, Bentley AR, Kraja AT, Ntalla I, Warren HR et al. ( 2019 ) . A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure . Human Molecular Genetics vol. 28 , ( 15 ) 2615 - 2633 .

Marouli E, Del Greco MF, Astley CM, Yang J, Ahmad S, Berndt SI, Caulfield MJ, Evangelou E et al. ( 2019 ) . Mendelian randomisation analyses find pulmonary factors mediate the effect of height on coronary artery disease . Communications Biology vol. 2 , ( 1 )

Wheway G, Consortium GER, Mitchison HM, Ambrose JC, Baple EL, Bleda M, Boardman-Pretty F, Boissiere JM et al. ( 2019 ) . Opportunities and Challenges for Molecular Understanding of Ciliopathies–The 100,000 Genomes Project . Frontiers in Genetics vol. 10 ,

Justice AE, Karaderi T, Highland HM, Young KL, Graff M, Lu Y, Turcot V, Auer PL et al. ( 2019 ) . Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution . Nature Genetics vol. 51 , ( 3 ) 452 - 469 .

van Setten J, Verweij N, Mbarek H, Niemeijer MN, Trompet S, Arking DE, Brody JA, Gandin I et al. ( 2019 ) . Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits . European Journal of Human Genetics vol. 27 , ( 6 ) 952 - 962 .

Erzurumluoglu AM, Liu M, Jackson VE, Barnes DR, Datta G, Melbourne CA, Young R, Batini C et al. ( 2019 ) . Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci . Molecular Psychiatry vol. 25 , ( 10 ) 2392 - 2409 .

McDonough CW, Warren HR, Jack JR, Motsinger-Reif AA, El Rouby NM, Gong Y, Mychaleckyj JC, Benavente OR et al. ( 2019 ) . DRUG-SNP INTERACTIONS AND CARDIOVASCULAR OUTCOMES: A GENOME-WIDE META-ANALYSIS IN THE INTERNATIONAL CONSORTIUM FOR ANTIHYPERTENSIVE PHARMACOGENOMICS STUDIES . CLINICAL PHARMACOLOGY & THERAPEUTICS . vol. 105 , S105 - S106 .

Giri A, Hellwege JN, Keaton JM, Park J, Qiu C, Warren HR, Torstenson ES, Kovesdy CP et al. ( 2018 ) . Trans-ethnic association study of blood pressure determinants in over 750,000 individuals . Nature Genetics vol. 51 , ( 1 ) 51 - 62 .

Brazel DM, Jiang Y, Hughey JM, Turcot V, Zhan X, Gong J, Batini C, Weissenkampen JD et al. ( 2018 ) . Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use . Biological Psychiatry

Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N et al. ( 2018 ) . Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits . Nat Genet vol. 50 , ( 12 ) 1755 - 1755 .

Collier DJ, Juhasz A, Agabiti‐Rosei E, Lloyd E, Hisada M, Zhao L, Kupfer S, Caulfield MJ ( 2018 ) . Efficacy and safety of azilsartan medoxomil/chlortalidone fixed‐dose combination in hypertensive patients uncontrolled on azilsartan medoxomil alone: A randomized trial . Journal of Clinical Hypertension vol. 20 , ( 10 ) 1473 - 1484 .

Allix-Béguec C, Arandjelovic I, Bi L, Beckert P, Bonnet M, Bradley P, Cabibbe AM, Cancino-Muñoz I et al. ( 2018 ) . Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing . New England Journal of Medicine vol. 379 , ( 15 ) 1403 - 1415 .

Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N et al. ( 2018 ) . Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits . Nature Genetics vol. 50 , ( 10 ) 1412 - 1425 .

Sosinsky A, Murugaesu N, Hamblin A, Ambrose J, Turnbull C, Henderson S, Rueda-Martin A, Fowler T et al. ( 2018 ) . 19P 100,000 Genomes Project: Cancer programme . Annals of Oncology . vol. 29 ,

Ng FL, Warren HR, Caulfield MJ ( 2018 ) . Hypertension genomics and cardiovascular prevention . Ann Transl Med vol. 6 , ( 15 ) 291 - 291 .

Sosinsky A, Antoniou P, Ambrose J, Mijuskovic M, Rueda-Martin A, Perez-Gil1 D, Serra E, Henderson S et al. ( 2018 ) . Abstract 434: 100,000 Genomes Project: Cancer program . Cancer Research . vol. 78 , 434 - 434 .

Whitworth J, Smith PS, Martin J-E, West H, Luchetti A, Rodger F, Clark G, Carss K et al. ( 2018 ) . Comprehensive Cancer-Predisposition Gene Testing in an Adult Multiple Primary Tumor Series Shows a Broad Range of Deleterious Variants and Atypical Tumor Phenotypes . American Journal of Human Genetics vol. 103 , ( 1 ) 3 - 18 .

Feitosa MF, Kraja AT, Chasman DI, Sung YJ, Winkler TW, Ntalla I, Guo X, Franceschini N et al. ( 2018 ) . Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries . PLoS One vol. 13 , ( 6 ) e0198166 - e0198166 .

Williams B, MacDonald TM, Morant SV, Webb DJ, Sever P, McInnes GT, Ford I, Cruickshank JK et al. ( 2018 ) . Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies . Lancet Diabetes Endocrinol vol. 6 , ( 6 ) 464 - 475 .

BROWN MJ ( 2018 ) . Investigation of the endocrine and haemodynamic changes in resistant hypertension, and its response to spironolactone or amiloride: the PATHWAY-2 mechanisms study . Lancet Diabetes and Endocrinology vol. 6 , ( 6 ) 464 - 475 .

Thomas ERA, Devereau A, Brittain H, Tucci A, Ryten M, Smedley D, Rendon A, Caulfield MJ et al. ( 2018 ) . Widespread uptake of the Human Phenotype Ontology (HPO) in the National Health Service (NHS) in England as part of the 100,000 Genomes Project . EUROPEAN JOURNAL OF HUMAN GENETICS . Conference: european society human genetics vol. 27 , 513 - 513 .

Sung YJ, Winkler TW, de las Fuentes L, Bentley AR, Brown MR, Kraja AT, Schwander K, Ntalla I et al. ( 2018 ) . A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure . American Journal of Human Genetics vol. 102 , ( 3 ) 375 - 400 .

Munroe PB, Jahangir SNS, Caulfield MJ ( 2018 ) . Genetics and Genomics of Systemic Hypertension . Cardiovascular Genetics and Genomics , Springer Nature

Shovlin CL, Nur F, St Prix MS, Redhead J, Alton EA, Bernabeu-Herrero ME, Fowler T, Caulfield M et al. ( 2018 ) . Hereditary haemorrhagic telangiectasia and the 100,000 genomes project . ANGIOGENESIS . vol. 21 , 125 - 125 .

Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T et al. ( 2017 ) . Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity . Nature Genetics vol. 50 , ( 1 ) 26 - 41 .

Pazoki R, Dehghan A, Evangelou E, Warren H, Gao H, Caulfield M, Elliott P, Tzoulaki I ( 2017 ) . Genetic Predisposition to High Blood Pressure and Lifestyle Factors . Circulation vol. 137 , ( 7 ) 653 - 661 .

McCarthy NS, Vangjeli C, Surendran P, Treumann A, Rooney C, Ho E, Sever P, Thom S et al. ( 2017 ) . Genetic variants in PPARGC1B and CNTN4 are associated with thromboxane A2 formation and with cardiovascular event free survival in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) . Atherosclerosis vol. 269 , 42 - 49 .

MacDonald TM, Williams B, Webb DJ, Morant S, Caulfield M, Cruickshank JK, Ford I, Sever P et al. ( 2017 ) . Combination Therapy Is Superior to Sequential Monotherapy for the Initial Treatment of Hypertension: A Double-Blind Randomized Controlled Trial . J Am Heart Assoc vol. 6 , ( 11 )

Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C et al. ( 2017 ) . Exome-wide association study of plasma lipids in >300,000 individuals . Nature Genetics vol. 49 , ( 12 ) 1758 - 1766 .

Ren M, Ng FL, Warren HR, Witkowska K, Baron M, Jia Z, Cabrera C, Zhang R et al. ( 2017 ) . The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle . Human Molecular Genetics vol. 27 , ( 1 ) 199 - 210 .

Kraja AT, Cook JP, Warren HR, Surendran P, Liu C, Evangelou E, Manning AK, Grarup N et al. ( 2017 ) . New Blood Pressure–Associated Loci Identified in Meta-Analyses of 475 000 Individuals . Circulation Genomic and Precision Medicine vol. 10 , ( 5 )

Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, Ntalla I, Surendran P et al. ( 2017 ) . Corrigendum: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk . Nat Genet vol. 49 , ( 10 ) 1558 - 1558 .

Wain LV, Vaez A, Jansen R, Joehanes R, van der Most PJ, Erzurumluoglu AM, O'Reilly PF, Cabrera CP et al. ( 2017 ) . Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney . Hypertension vol. 70 , ( 3 ) e4 - e19 .

Song C, Burgess S, Eicher JD, O'Donnell CJ, Johnson AD, Huang J, Sabater-Lleal M, Asselbergs FW et al. ( 2017 ) . Causal effect of plasminogen activator inhibitor type 1 on coronary heart disease . Journal of the American Heart Association vol. 6 , ( 6 )

Dale CE, Fatemifar G, Palmer TM, White J, Prieto-Merino D, Zabaneh D, Engmann JEL, Shah T et al. ( 2017 ) . Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus . Circulation vol. 135 , ( 24 ) 2373 - 2388 .

Lian F, Caulfield MJ ( 2017 ) . Status and future of genomics in blood pressure . European Heart Journal vol. 38 , ( 14 ) 1011 - 1013 .

MUNROE PB, Caulfield M, Stirrups K, van den Berg M, Warren H, Cabrera CP ( 2017 ) . Discovery of novel heart rate-associated loci using the exome chip . Human Molecular Genetics

Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, Ntalla I, Surendran P et al. ( 2017 ) . Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk . Nat Genet vol. 49 , ( 3 ) 403 - 415 .

Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, Fine RS, Lu Y et al. ( 2017 ) . Rare and low-frequency coding variants alter human adult height . Nature vol. 542 , ( 7640 ) 186 - 190 .

Ng FL, Boedtkjer E, Witkowska K, Ren M, Zhang R, Tucker A, Aalkjær C, Caulfield MJ et al. ( 2017 ) . Increased NBCn1 expression, Na+/HCO3- co-transport and intracellular pH in human vascular smooth muscle cells with a risk allele for hypertension . Hum Mol Genet

Caulfield M ( 2017 ) . The 100,000 Genomes Project Transforming Healthcare . GENETIC EPIDEMIOLOGY . vol. 41 , 644 - 644 .

Noordam R, Sitlani CM, Avery CL, Stewart JD, Gogarten SM, Wiggins KL, Trompet S, Warren HR et al. ( 2016 ) . A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium . J Med Genet

Carss KJ, Arno G, Erwood M, Stephens J, Sanchis-Juan A, Hull S, Megy K, Grozeva D et al. ( 2016 ) . Comprehensive Rare Variant Analysis via Whole-Genome Sequencing to Determine the Molecular Pathology of Inherited Retinal Disease . American Journal of Human Genetics vol. 100 , ( 1 ) 75 - 90 .

Rathod KS, Jones DA, Van-Eijl TJA, Tsang H, Warren H, Hamshere SM, Kapil V, Jain AK et al. ( 2016 ) . Randomised, double-blind, placebo-controlled study investigating the effects of inorganic nitrate on vascular function, platelet reactivity and restenosis in stable angina: protocol of the NITRATE-OCT study . BMJ Open vol. 6 , ( 12 )

MUNROE PB ( 2016 ) . Trans-ancestry meta-analyses identify novel rare and common variants associated with blood pressure and hypertension . Nature Genetics

MUNROE PB ( 2016 ) . The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals . Nature Genetics

Ng FL, Boedtkjer E, Ye S, Caulfield M ( 2016 ) . LBOS 02-04 BLOOD PRESSURE-ASSOCIATED POLYMORPHISMS IN SLC4A7 (SODIUM/BICARBONATE CO-TRANSPORTER NBCn1) ARE LINKED TO GENE EXPRESSION AND INTRACELLULAR pH REGULATION . Journal of Hypertension . vol. 34 , e549 - e550 .

Postmus I, Warren HR, Trompet S, Arsenault BJ, Avery CL, Bis JC, Chasman DI, de Keyser CE et al. ( 2016 ) . Meta-analysis of genome-wide association studies of HDL cholesterol response to statins . Journal of Medical Genetics

Ng F, Bødtkjer E, Caulfield MJ, Ye S ( 2016 ) . [OP.7C.02] BLOOD PRESSURE-ASSOCIATED POLYMORPHISMS IN SLC4A7 (SODIUM/BICARBONATE CO-TRANSPORTER NBCN1) ARE LINKED WITH GENE EXPRESSION AND INTRACELLULAR PH REGULATION . Journal of Hypertension . vol. 34 ,

Ren M, Ng F, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S et al. ( 2016 ) . [OP.7C.08] BLOOD-PRESSURE ASSOCIATED VARIANTS IN NPR3 AFFECT HUMAN VASCULAR SMOOTH MUSCLE CELLS PROLIFERATION AND CALCIUM RESPONSE TO ANGIOTENSIN II . vol. 34 , is. &NA; , Wolters Kluwer

Zhang R, Witkowska K, Afonso Guerra-Assunção J, Ren M, Ng FL, Mauro C, Tucker AT, Caulfield MJ et al. ( 2016 ) . A blood pressure-associated variant of the SLC39A8 gene influences cellular cadmium accumulation and toxicity . Hum Mol Genet vol. 25 , ( 18 ) 4117 - 4126 .

Kanoni S, Masca NGD, Stirrups KE, Varga TV, Warren HR, Scott RA, Southam L, Zhang W et al. ( 2016 ) . Analysis with the exome array identifies multiple new independent variants in lipid loci . Human Molecular Genetics vol. 25 , ( 18 ) ddw227 - ddw227 .

Yang W, Ng FL, Chan K, Pu X, Poston RN, Ren M, An W, Zhang R et al. ( 2016 ) . Coronary-Heart-Disease-Associated Genetic Variant at the COL4A1/COL4A2 Locus Affects COL4A1/COL4A2 Expression, Vascular Cell Survival, Atherosclerotic Plaque Stability and Risk of Myocardial Infarction . PLoS Genetics vol. 12 , ( 7 ) e1006127 - e1006127 .

Raveendran R, Heybroek W, Caulfield M, Lawson M, Abrams SML, Wrigley PFM, Slevin M, Turner P ( 2016 ) . Indomethacin and Protein Binding of Methotrexate . Human & Experimental Toxicology vol. 11 , ( 4 ) 291 - 293 .

Bodea CA, Neale BM, Ripke S, Daly MJ, Devlin B, Roeder K ( 2016 ) . A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies . American Journal of Human Genetics vol. 98 , ( 5 ) 857 - 868 .

Leusink M, der Zee AHM-V, Ding B, Drenos F, van Iperen EP, Warren HR, Caulfield MJ, Cupples LA et al. ( 2016 ) . A genetic risk score is associated with statin-induced low-density lipoprotein cholesterol lowering . Pharmacogenomics vol. 17 , ( 6 ) 583 - 591 .

Diver LA, MacKenzie SM, Fraser R, McManus F, Freel EM, Alvarez-Madrazo S, McClure JD, Friel EC et al. ( 2016 ) . Common Polymorphisms at the CYP17A1 Locus Associate With Steroid Phenotype: Support for Blood Pressure Genome-Wide Association Study Signals at This Locus . Hypertension vol. 67 , ( 4 ) 724 - 732 .

Lessard S, Manning AK, Low-Kam C, Auer PL, Giri A, Graff M, Schurmann C, Yaghootkar H et al. ( 2016 ) . Testing the role of predicted gene knockouts in human anthropometric trait variation . Human Molecular Genetics vol. 25 , ( 10 ) 2082 - 2092 .

Burchell AE, Chan K, Ratcliffe LEK, Hart EC, Saxena M, Collier DJ, Jain AK, Mathur A et al. ( 2016 ) . Controversies Surrounding Renal Denervation: Lessons Learned From Real‐World Experience in Two United Kingdom Centers . Journal of Clinical Hypertension vol. 18 , ( 6 ) 585 - 592 .

Sharp ASP, Davies JE, Lobo MD, Bent CL, Mark PB, Burchell AE, Thackray SD, Martin U et al. ( 2016 ) . Renal artery sympathetic denervation: observations from the UK experience . Clinical Research in Cardiology vol. 105 , ( 6 ) 544 - 552 .

Pattaro C, Teumer A, Gorski M, Chu AY, Li M, Mijatovic V, Garnaas M, Tin A et al. ( 2016 ) . Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function . Nature Communications vol. 7 , ( 1 )

Ng FL, Boedtkjer E, Ye S, Caulfield M ( 2016 ) . Blood pressure-associated polymorphisms in SLC4A7 (sodium/bicarbonate co-transporter NBCn1) are linked to gene expression and intracellular pH (pHi) regulation . vol. 30 , is. 10 , pp. 636 - 636 .

Evangelou E, Warren H, Cabrera C, Gao H, Tzoulaki I, Barnes M, Caulfield M, Elliott P ( 2016 ) . UK Biobank GWAS Identifies over 100 Novel Variants Associated with Blood Pressure . vol. 40 , is. 7 , pp. 613 - 613 .

Doyle JJ, Doyle AJ, Wilson NK, Habashi JP, Bedja D, Whitworth RE, Lindsay ME, Schoenhoff F et al. ( 2015 ) . A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome . ELIFE vol. 4 , Article ARTN e08648 ,

Brown MJ, Williams B, Morant SV, Webb DJ, Caulfield MJ, Cruickshank JK, Ford I, McInnes G et al. ( 2015 ) . Effect of amiloride, or amiloride plus hydrochlorothiazide, versus hydrochlorothiazide on glucose tolerance and blood pressure (PATHWAY-3): a parallel-group, double-blind randomised phase 4 trial . The Lancet Diabetes & Endocrinology vol. 4 , ( 2 ) 136 - 147 .

Wain LV, Shrine N, Miller S, Jackson VE, Ntalla I, Artigas MS, Billington CK, Kheirallah AK et al. ( 2015 ) . Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank . The Lancet Respiratory Medicine vol. 3 , ( 10 ) 769 - 781 .

Williams B, MacDonald TM, Morant S, Webb DJ, Sever P, McInnes G, Ford I, Cruickshank JK et al. ( 2015 ) . Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial . The Lancet vol. 386 , ( 10008 ) 2059 - 2068 .

Ren M, Ng FL, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S et al. ( 2015 ) . Abstract P048: Blood-Pressure Associated Variants in Natriuretic Peptide Receptor C Affect Human Vascular Smooth Muscle Cells Proliferation and Calcium Flux in Response to Angiotensin II . Hypertension vol. 66 , ( suppl_1 )

Treibel TA, Zemrak F, Sado DM, Banypersad SM, White SK, Maestrini V, Barison A, Patel V et al. ( 2015 ) . Extracellular volume quantification in isolated hypertension - changes at the detectable limits? . Journal of Cardiovascular Magnetic Resonance vol. 17 , ( 1 )

Brown MJ, Williams B, MacDonald TM, Caulfield M, Cruickshank JK, McInnes G, Sever P, Webb DJ et al. ( 2015 ) . Comparison of single and combination diuretics on glucose tolerance (PATHWAY-3): protocol for a randomised double-blind trial in patients with essential hypertension . BMJ Open vol. 5 , ( 8 )

MacDonald TM, Williams B, Caulfield M, Cruickshank JK, McInnes G, Sever P, Webb DJ, Mackenzie IS et al. ( 2015 ) . Monotherapy versus dual therapy for the initial treatment of hypertension (PATHWAY-1): a randomised double-blind controlled trial . BMJ Open vol. 5 , ( 8 )

Williams B, MacDonald TM, Caulfield M, Cruickshank JK, McInnes G, Sever P, Webb DJ, Salsbury J et al. ( 2015 ) . Prevention And Treatment of Hypertension With Algorithm-based therapy (PATHWAY) number 2: protocol for a randomised crossover trial to determine optimal treatment for drug-resistant hypertension . BMJ Open vol. 5 , ( 8 )

Joshi PK, Esko T, Mattsson H, Eklund N, Gandin I, Nutile T, Jackson AU, Schurmann C et al. ( 2015 ) . Directional dominance on stature and cognition in diverse human populations . Nature vol. 523 , ( 7561 ) 459 - 462 .

Juhasz A, Collier D, Caulfield M, Agabiti-Rosei E, Huang P, Hisada M, Zhao L, Kupfer S ( 2015 ) . Achievement of Blood Pressure Targets and Safety of Azilsartan Medoxomil/Chlorthalidone Fixed Dose Combination versus Azilsartan Medoxomil in Hypertensive Patients Uncontrolled on Monotherapy . Journal of Hypertension . vol. 33 ,

Khanji M, Balawon A, Boubertakh R, Zemrak F, Collier D, Caulfield MJ, Petersen SE ( 2015 ) . LB01.07 . Journal of Hypertension . vol. 33 ,

Zhang R, Witkowska K, Ng F, Caulfield MJ, Ye S ( 2015 ) . LB03.08 . Journal of Hypertension vol. 33 , ( &NA; )

Ren M, Ng F, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S et al. ( 2015 ) . PP.LB03.07 . Journal of Hypertension . vol. 33 , e518 - e519 .

Yousaf N, Low WY, Onipinla A, Mein C, Caulfield M, Munroe PB, Chernajovsky Y ( 2015 ) . Differences between disease‐associated endoplasmic reticulum aminopeptidase 1 (ERAP1) isoforms in cellular expression, interactions with tumour necrosis factor receptor 1 (TNF‐R1) and regulation by cytokines . Clinical & Experimental Immunology vol. 180 , ( 2 ) 289 - 304 .

Poulter NR, Prabhakaran D, Caulfield M ( 2015 ) . Hypertension . The Lancet vol. 386 , ( 9995 ) 801 - 812 .

Huffman JE, Albrecht E, Teumer A, Mangino M, Kapur K, Johnson T, Kutalik Z, Pirastu N et al. ( 2015 ) . Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans . PLOS ONE vol. 10 , ( 3 )

Padmanabhan S, Caulfield M, Dominiczak AF ( 2015 ) . Genetic and Molecular Aspects of Hypertension . Circulation Research vol. 116 , ( 6 ) 937 - 959 .

Mega JL, Stitziel NO, Smith JG, Chasman DI, Caulfield MJ, Devlin JJ, Nordio F, Hyde CL et al. ( 2015 ) . Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials . The Lancet vol. 385 , ( 9984 ) 2264 - 2271 .

Kapil V, Khambata RS, Robertson A, Caulfield MJ, Ahluwalia A ( 2015 ) . Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: A randomized, phase 2, double-blind, placebo-controlled study . Hypertension vol. 65 , ( 2 ) 320 - 327 .

Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S et al. ( 2015 ) . Genetic studies of body mass index yield new insights for obesity biology . Nature vol. 518 , ( 7538 ) 197 - 206 .

Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Mägi R, Strawbridge RJ, Pers TH et al. ( 2015 ) . New genetic loci link adipose and insulin biology to body fat distribution . Nature vol. 518 , ( 7538 ) 187 - 196 .

Cabrera CP, Ng FL, Warren HR, Barnes MR, Munroe PB, Caulfield MJ ( 2015 ) . Exploring hypertension genome‐wide association studies findings and impact on pathophysiology, pathways, and pharmacogenetics . WIREs Mechanisms of Disease vol. 7 , ( 2 ) 73 - 90 .

Ren M, Ng FL, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S et al. ( 2015 ) . Blood-pressure associated variants in <i>NPR3</i> affect human vascular smooth muscle cells proliferation and calcium response to angiotensin II . vol. 29 , is. 10 , pp. 624 - 624 .

Witkowska K, Ren M, Caulfield M ( 2015 ) . Chapter 23 Genetic Markers in Prediction of Cardiovascular Disease . Early Vascular Aging (EVA) , Elsevier

Witkowska K, Ren M, Caulfield M ( 2015 ) . Genetic Markers in Prediction of Cardiovascular Disease . Early Vascular Aging (EVA): New Directions in Cardiovascular Protection ,

Zhang R, Witkowska K, Ng FL, Caulfield M, Ye S ( 2015 ) . Hypertension related variant of <i>SLC39A8</i> gene influences cadmium uptake and cell toxicity . JOURNAL OF HUMAN HYPERTENSION vol. 29 , ( 10 ) 645 - 645 .

Warren H, Sever P, Poulter N, Stanton A, Caulfield M, Munroe P ( 2015 ) . Pharmacogenetic GWAS meta-analysis of response to antihypertensive drugs . JOURNAL OF HUMAN HYPERTENSION vol. 29 , ( 10 ) 627 - 627 .

Warren H, Sever P, Poulter N, Stantont A, Caulfield M, Munroe P ( 2015 ) . Pharmacogenetic Meta-Analysis of Response to Antihypertensive Drugs within ASCOT . HUMAN HEREDITY . vol. 79 , 49 - 49 .

Rautanen A, Mills TC, Gordon AC, Hutton P, Steffens M, Nuamah R, Chiche J-D, Parks T et al. ( 2014 ) . Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study . The Lancet Respiratory Medicine vol. 3 , ( 1 ) 53 - 60 .

Lobo MD, de Belder MA, Cleveland T, Collier D, Dasgupta I, Deanfield J, Kapil V, Knight C et al. ( 2014 ) . Joint UK societies’ 2014 consensus statement on renal denervation for resistant hypertension . Heart vol. 101 , ( 1 )

Kapil V, Khambata RS, Robertson A, Caulfield MJ, Ahluwalia A ( 2014 ) . Dietary Nitrate Provides Sustained Blood Pressure Lowering in Hypertensive Patients . Hypertension vol. 65 , ( 2 ) 320 - 327 .

Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K et al. ( 2014 ) . Defining the role of common variation in the genomic and biological architecture of adult human height . Nature Genetics vol. 46 , ( 11 ) 1173 - 1186 .

Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K et al. ( 2014 ) . Defining the role of common variation in the genomic and biological architecture of adult human height . Nature Genetics vol. 46 , ( 11 ) 1173 - 1186 .

Moyes AJ, Khambata RS, Villar I, Bubb KJ, Baliga RS, Lumsden NG, Xiao F, Gane PJ et al. ( 2014 ) . Endothelial C-type natriuretic peptide maintains vascular homeostasis . J Clin Invest vol. 124 , ( 9 ) 4039 - 4051 .

Postmus I, Trompet S, Deshmukh HA, Barnes MR, Li X, Warren HR, Chasman DI, Zhou K et al. ( 2014 ) . Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins . Nature Communications vol. 5 , Article 5068 ,

Arking DE, Pulit SL, Crotti L, van der Harst P, Munroe PB, Koopmann TT, Sotoodehnia N, Rossin EJ et al. ( 2014 ) . Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization . Nat Genet vol. 46 , ( 8 ) 826 - 836 .

Hoggart CJ, Venturini G, Mangino M, Gomez F, Ascari G, Zhao JH, Teumer A, Winkler TW et al. ( 2014 ) . Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index . PLOS Genetics vol. 10 , ( 7 )

Ganesh SK, Chasman DI, Larson MG, Guo X, Verwoert G, Bis JC, Xiangjun GU, Smith AV et al. ( 2014 ) . Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations . American Journal of Human Genetics vol. 95 , ( 1 ) 49 - 65 .

Ganesh SK, Chasman DI, Larson MG, Guo X, Verwoert G, Bis JC, Gu X, Smith AV et al. ( 2014 ) . Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations . Am J Hum Genet vol. 95 , ( 1 ) 49 - 65 .

Mancia G, van Zwieten PA ( 2014 ) . ANTIHYPERTENSIVE TREATMENT STRATEGIES . Manual of Hypertension of the European Society of Hypertension , Taylor & Francis

Padmanabhan S, Caulfield M, Dominiczak AF ( 2014 ) . GENETIC BASIS OF BLOOD PRESSURE AND HYPERTENSION . Manual of Hypertension of the European Society of Hypertension , Taylor & Francis

Rapsomaniki E, Timmis A, George J, Pujades-Rodriguez M, Shah AD, Denaxas S, White IR, Caulfield MJ et al. ( 2014 ) . Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people . Lancet vol. 383 , ( 9932 ) 1899 - 1911 .

Tragante V, Barnes MR, Ganesh SK, Lanktree MB, Guo W, Franceschini N, Smith EN, Johnson T et al. ( 2014 ) . Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci . Am J Hum Genet vol. 94 , ( 3 ) 349 - 360 .

Saxena M, Jain A, Mathur A, Knight C, Caulfield M, Collier D, Lobo M ( 2014 ) . Early reduction in blood pressure and heart rate variability following multielectrode radio-frequency renal denervation in medicines intolerant patients . JOURNAL OF HUMAN HYPERTENSION . vol. 28 , 647 - 647 .

Mahajan A, Go MJ, Zhang W, Below JE, Gaulton KJ, Ferreira T, Horikoshi M, Johnson AD et al. ( 2014 ) . Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility . NATURE GENETICS vol. 46 , ( 3 ) 234 - + .

Burchell A, Chan K, Ratcliffe L, Hart E, Saxena M, Collier D, Jain A, Mathur A et al. ( 2014 ) . Highly variable response to renal denervation for resistant hypertension - real world experience from 2 UK centres . JOURNAL OF HUMAN HYPERTENSION . vol. 28 , 645 - 646 .

Caulfield M ( 2014 ) . Home Blood Pressure Monitoring: New Evidence for an Expanded Role . PLOS MEDICINE vol. 11 , ( 1 ) Article ARTN e1001592 ,

Postmus I, Trompet S, Warren HR, Jukema JW, Caulfield MJ ( 2014 ) . Pharmacogenetic GWAS meta-analysis of LDL cholesterol response to statins . JOURNAL OF HUMAN HYPERTENSION . vol. 28 , 624 - 624 .

Dobson RJB, Munroe PB, Caulfield MJ, Saqi MAS ( 2014 ) . Protein interaction networks associated with cardiovascular disease and cancer: exploring the effect of bias on shared network properties . INTERNATIONAL JOURNAL OF DATA MINING AND BIOINFORMATICS vol. 9 , ( 4 ) 339 - 357 .

Thorgeirsson TE, Gudbjartsson DF, Sulem P, Besenbacher S, Styrkarsdottir U, Thorleifsson G, Walters GB, Furberg H et al. ( 2013 ) . A common biological basis of obesity and nicotine addiction . Translational Psychiatry vol. 3 , ( 10 ) e308 - e308 .

Yadav S, Cotlarciuc I, Munroe PB, Khan MS, Nalls MA, Bevan S, Cheng Y-C, Chen W-M et al. ( 2013 ) . Genome-wide analysis of blood pressure variability and ischemic stroke . Stroke vol. 44 , ( 10 ) 2703 - 2709 .

Shah T, Engmann J, Dale C, Shah S, White J, Giambartolomei C, McLachlan S, Zabaneh D et al. ( 2013 ) . Correction: Population Genomics of Cardiometabolic Traits: Design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium . PLOS ONE vol. 8 , ( 9 )

Shah T, Engmann J, Dale C, Shah S, White J, Giambartolomei C, McLachlan S, Zabaneh D et al. ( 2013 ) . Population Genomics of Cardiometabolic Traits: Design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium . PLoS ONE vol. 8 , ( 8 )

Caulfield M ( 2013 ) . Advances in genomics of blood pressure—time for translation . Clinical Therapeutics vol. 35 , ( 8 )

Hu Y-J, Berndt SI, Gustafsson S, Ganna A, Consortium GIOAT, Berndt SI, Gustafsson S, Mägi R et al. ( 2013 ) . Meta-analysis of Gene-Level Associations for Rare Variants Based on Single-Variant Statistics . American Journal of Human Genetics vol. 93 , ( 2 ) 236 - 248 .

Ganesh SK, Tragante V, Guo W, Guo Y, Lanktree MB, Smith EN, Johnson T, Castillo BA et al. ( 2013 ) . Loci influencing blood pressure identified using a cardiovascular gene-centric array . Human Molecular Genetics vol. 22 , ( 16 ) 3394 - 3395 .

Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, Kilpeläinen TO, Esko T et al. ( 2013 ) . Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits . PLoS Genetics vol. 9 , ( 6 )

Hall AS, Newby DE, Gale CP, Gillott RG, Scarlett S, Wood S, Gower JD, Williams B et al. ( 2013 ) . 027 THE IMPACT OF STRATEGIC UK NATIONAL HEALTH SERVICE (NHS) FUNDING ON THE PATIENT RECRUITMENT TO ‘ATHEROTHROMBOSIS’ RESEARCH STUDIES. THE UK NHS ATHEROTHROMBOSIS RESEARCH NETWORK . Heart vol. 99 , ( suppl 2 )

Pu X, Xiao Q, Kiechl S, Chan K, Ng FL, Gor S, Poston RN, Fang C et al. ( 2013 ) . YIA3: ADAMTS7 CLEAVAGE AND VASCULAR SMOOTH MUSCLE CELL MIGRATION IS AFFECTED BY A CORONARY ARTERY DISEASE ASSOCIATED VARIANT . Heart . vol. 99 ,

Munroe PB, Barnes MR, Caulfield MJ ( 2013 ) . Advances in blood pressure genomics . Circ Res vol. 112 , ( 10 ) 1365 - 1379 .

Ghosh SM, Kapil V, Fuentes-Calvo I, Bubb KJ, Pearl V, Milsom AB, Khambata R, Maleki-Toyserkani S et al. ( 2013 ) . Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential . Hypertension vol. 61 , ( 5 ) 1091 - 1102 .

Huertas-Vazquez A, Nelson CP, Guo X, Reinier K, Uy-Evanado A, Teodorescu C, Ayala J, Jerger K et al. ( 2013 ) . Novel Loci Associated with Increased Risk of Sudden Cardiac Death in the Context of Coronary Artery Disease . PLOS ONE vol. 8 , ( 4 )

Ehret GB, Caulfield MJ ( 2013 ) . Genes for blood pressure: an opportunity to understand hypertension . EUROPEAN HEART JOURNAL vol. 34 , ( 13 ) 951 - 961 .

Pu X, Xiao Q, Kiechl S, Chan K, Ng FL, Gor S, Poston RN, Fang C et al. ( 2013 ) . ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated variant . American Journal of Human Genetics vol. 92 , ( 3 ) 366 - 374 .

Pu X, Xiao Q, Kiechl S, Chan K, Ng FL, Gor S, Poston RN, Fang C et al. ( 2013 ) . ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated variant . Am J Hum Genet vol. 92 , ( 3 ) 366 - 374 .

Vimaleswaran KS, Berry DJ, Lu C, Tikkanen E, Pilz S, Hiraki LT, Cooper JD, Dastani Z et al. ( 2013 ) . Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts . PLOS Medicine vol. 10 , ( 2 )

Köttgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark C, Pistis G, Ruggiero D et al. ( 2013 ) . Genome-wide association analyses identify 18 new loci associated with serum urate concentrations . Nature Genetics vol. 45 , ( 2 ) 145 - 154 .

Treibel TA, Zemrak F, White SK, Sado D, Banypersad SM, Maestrini V, Caulfield M, Petersen SE et al. ( 2013 ) . Diffuse interstitial fibrosis in well-controlled hypertension . Journal of Cardiovascular Magnetic Resonance vol. 15 , ( Suppl 1 )

Treibel TA, White SK, Sado D, Zemrak F, Banypersad SM, Flett A, Caulfield M, Herrey AS et al. ( 2013 ) . Interstitial expansion in pressure overload left ventricular hypertrophy . Journal of Cardiovascular Magnetic Resonance vol. 15 , ( Suppl 1 )

Alvarez-Madrazo S, MacKenzie SM, Davies E, Fraser R, Lee W-K, Brown M, Caulfield MJ, Dominiczak AF et al. ( 2013 ) . Common Polymorphisms in the <i>CYP11B1</i> and <i>CYP11B2</i> Genes: Evidence for a Digenic Influence on Hypertension . HYPERTENSION vol. 61 , ( 1 ) 232 - + .

Koettgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark C, Pistis G, Ruggiero D et al. ( 2013 ) . Genome-wide association analyses identify 18 new loci associated with serum urate concentrations . NATURE GENETICS vol. 45 , ( 2 ) 145 - 154 .

Berndt SI, Gustafsson S, Maegi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL et al. ( 2013 ) . Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture . NATURE GENETICS vol. 45 , ( 5 ) 501 - U69 .

Ganesh SK, Tragante V, Guo W, Guo Y, Lanktree MB, Smith EN, Johnson T, Castillo BA et al. ( 2013 ) . Loci influencing blood pressure identified using a cardiovascular gene-centric array . HUMAN MOLECULAR GENETICS vol. 22 , ( 8 ) 1663 - 1678 .

Robinson PJ, Ng FL, Lobo MD, Akker S, Drake WM, Cavlan D, Caulfield MJ ( 2013 ) . Phaeochromocytoma-paraganglioma syndrome presenting as a para-renal mass: A case report . JOURNAL OF HUMAN HYPERTENSION vol. 27 , ( 10 ) 654 - 655 .

Postmus I, Trompet S, Warren H, Jukema JW, Caulfield M ( 2013 ) . Pharmacogenetic GWAS Meta-Analysis of LDL Cholesterol Response to Statins . HUMAN HEREDITY . vol. 76 , 101 - 101 .

Huang C, Ng F, Kapil V, Caulfield M, Lobo M ( 2013 ) . Prognostic significance of short term blood pressure variability in a tertiary referral centre population . JOURNAL OF HUMAN HYPERTENSION vol. 27 , ( 10 ) 651 - 651 .

O'Byrne S, Caulfield M ( 2012 ) . Genetics of Hypertension . Drugs vol. 56 , ( 2 ) 203 - 214 .

Eyre S, Bowes J, Diogo D, Lee A, Barton A, Martin P, Zhernakova A, Stahl E et al. ( 2012 ) . High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis . Nature Genetics vol. 44 , ( 12 ) 1336 - 1340 .

Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee JC, Philip Schumm L et al. ( 2012 ) . Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease . Nature vol. 491 , ( 7422 ) 119 - 124 .

Guo Y, Lanktree MB, Taylor KC, Hakonarson H, Lange LA, Keating BJ ( 2012 ) . Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals . Human Molecular Genetics vol. 22 , ( 1 ) 184 - 201 .

Motterle A, Pu X, Wood H, Xiao Q, Gor S, Ng FL, Chan K, Cross F et al. ( 2012 ) . Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells . Hum Mol Genet vol. 21 , ( 18 ) 4021 - 4029 .

Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, MäGi R, Strawbridge RJ et al. ( 2012 ) . Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways . Nature Genetics vol. 44 , ( 9 ) 991 - 1005 .

Okada Y, Sim X, Go MJ, Wu J-Y, Gu D, Takeuchi F, Takahashi A, Maeda S et al. ( 2012 ) . Meta-analysis identifies multiple loci associated with kidney function–related traits in east Asian populations . Nature Genetics vol. 44 , ( 8 ) 904 - 909 .

Lanktree MB, Guo Y, Murtaza M, Glessner JT, Bailey SD, Onland-Moret NC, Lettre G, Ongen H et al. ( 2012 ) . Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height . American Journal of Human Genetics vol. 90 , ( 6 ) 1116 - 1117 .

Louis-Dit-Picard H, Barc J, Trujillano D, Miserey-Lenkei S, Bouatia-Naji N, Pylypenko O, Beaurain G, Bonnefond A et al. ( 2012 ) . Erratum: KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron . Nature Genetics vol. 44 , ( 5 ) 609 - 609 .

Saxena R, Elbers CC, Guo Y, Peter I, Gaunt TR, Mega JL, Lanktree MB, Tare A et al. ( 2012 ) . Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci . American Journal of Human Genetics vol. 90 , ( 4 )

Dastani Z, Hivert M-F, Timpson N, Perry JRB, Yuan X, Scott RA, Henneman P, Heid IM et al. ( 2012 ) . Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals . PLOS Genetics vol. 8 , ( 3 )

Angelakopoulou A, Shah T, Sofat R, Shah S, Berry DJ, Cooper J, Palmen J, Tzoulaki I et al. ( 2012 ) . Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration . Eur Heart J vol. 33 , ( 3 ) 393 - 407 .

Salvi E, Kutalik Z, Glorioso N, Benaglio P, Frau F, Kuznetsova T, Arima H, Hoggart C et al. ( 2012 ) . Genomewide association study using a high-density single nucleotide polymorphism array and case-control design identifies a novel essential hypertension susceptibility locus in the promoter region of endothelial NO synthase . Hypertension vol. 59 , ( 2 ) 248 - 255 .

Motterle A, Xiao Q, Kiechl S, Pender SLF, Morris GE, Willeit J, Caulfield MJ, Ye S ( 2012 ) . Influence of matrix metalloproteinase-12 on fibrinogen level . Atherosclerosis vol. 220 , ( 2 ) 351 - 354 .

Louis-Dit-Picard H, Barc J, Trujillano D, Miserey-Lenkei S, Bouatia-Naji N, Pylypenko O, Beaurain G, Bonnefond A et al. ( 2012 ) . <i>KLHL3</i> mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron . NATURE GENETICS vol. 44 , ( 4 ) 456 - + .

Maller JB, McVean G, Byrnes J, Vukcevic D, Palin K, Su Z, Howson JMM, Auton A et al. ( 2012 ) . Bayesian refinement of association signals for 14 loci in 3 common diseases . NATURE GENETICS vol. 44 , ( 12 ) 1294 - 1301 .

Choi H, Plenge RM, Koettgen A, Vitart V, Bochud M, Gieger C, Caulfield M, Ciullo M et al. ( 2012 ) . Genetic Variants of Serum Uric Acid and Gout: An Analysis of &gt; 170,000 Individuals . ARTHRITIS AND RHEUMATISM . vol. 64 , S696 - S697 .

Islam M, Jafar T, Wood A, De Silva M, Caulfield M, Chaturvedi N, Frayling T ( 2012 ) . Genetic risk scores are associated with diabetes related traits in South Asians and provide tools for Mendelian randomization studies . CIRCULATION . vol. 125 , E680 - E680 .

Caulfield M ( 2012 ) . Genetics of Blood Pressure . JOURNAL OF PATHOLOGY . vol. 226 , S2 - S2 .

Surendran P, Vangjeli C, McCarthy N, Thom S, Sever P, O'Brien E, Poulter N, Mayet J et al. ( 2012 ) . Genome-wide association analysis identifies the MTHFR-CLCN6-NPPA-NPPB gene cluster as an important influence on BNP levels-implications for the use of BNP levels in the diagnosis and therapeutic monitoring of heart failure-an ASCOT sub study . JOURNAL OF HUMAN HYPERTENSION vol. 26 , ( 10 ) 620 - 620 .

Deshmukh HA, Colhoun HM, Johnson T, McKeigue PM, Betteridge DJ, Durrington PN, Fuller JH, Livingstone S et al. ( 2012 ) . Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a) . JOURNAL OF LIPID RESEARCH vol. 53 , ( 5 ) 1000 - 1011 .

Saxena R, Elbers CC, Guo Y, Peter I, Gaunt TR, Mega JL, Lanktree MB, Tare A et al. ( 2012 ) . Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci . AMERICAN JOURNAL OF HUMAN GENETICS vol. 90 , ( 3 ) 410 - 425 .

Asselbergs FW, Guo Y, van Iperen EPA, Sivapalaratnam S, Tragante V, Lanktree MB, Lange LA, Almoguera B et al. ( 2012 ) . Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci . AMERICAN JOURNAL OF HUMAN GENETICS vol. 91 , ( 5 ) 823 - 838 .

Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, Mägi R, Strawbridge RJ et al. ( 2012 ) . Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways . Nature Genetics

Islam M, Jafar TH, Wood AR, De Silva NMG, Caulfield M, Chaturvedi N, Frayling TM ( 2012 ) . Multiple genetic variants explain measurable variance in type 2 diabetes-related traits in Pakistanis . DIABETOLOGIA vol. 55 , ( 8 ) 2193 - 2204 .

Doyle AJ, Doyle JJ, Bessling SL, Maragh S, Lindsay ME, Schepers D, Gillis E, Mortier G et al. ( 2012 ) . Mutations in the TGF-β repressor <i>SKI</i> cause Shprintzen-Goldberg syndrome with aortic aneurysm . NATURE GENETICS vol. 44 , ( 11 ) 1249 - 1254 .

McManus RJ, Caulfield M, Williams B ( 2012 ) . NICE hypertension guideline 2011: evidence based evolution . BMJ-BRITISH MEDICAL JOURNAL vol. 344 , Article ARTN e181 ,

Saxena M, Collier D, Caulfield M, Lobo M ( 2012 ) . Patients with resistant hypertension warrant a trial of salt restriction before and after renal denervation (RD) . JOURNAL OF HUMAN HYPERTENSION vol. 26 , ( 10 ) 619 - 619 .

Chan K, Ng FL, Saxena M, Collier D, Matson M, Jain A, Caulfield M, Lobo M ( 2012 ) . Renal denervation in resistant hypertension-a prospective case series . JOURNAL OF HUMAN HYPERTENSION vol. 26 , ( 10 ) 631 - 631 .

Johnson T, Gaunt TR, Newhouse SJ, Padmanabhan S, Tomaszewski M, Kumari M, Morris RW, Tzoulaki I et al. ( 2011 ) . Blood pressure loci identified with a gene-centric array . Am J Hum Genet vol. 89 , ( 6 ) 688 - 700 .

Bown MJ, Jones GT, Harrison SC, Wright BJ, Bumpstead S, Baas AF, Gretarsdottir S, Badger SA et al. ( 2011 ) . Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1 . American Journal of Human Genetics vol. 89 , ( 5 ) 619 - 627 .

Chambers JC, Zhang WH, Sehmi J, Li XZ, Wass MN, Van der Harst P, Holm H, Sanna S et al. ( 2011 ) . Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma . NAT GENET vol. 43 , ( 11 ) 1131 - U129 .

Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, Thorleifsson G, Zillikens MC et al. ( 2011 ) . Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution . Nature Genetics vol. 43 , ( 11 ) 1164 - 1164 .

Williams B, Krause T, Lovibond K, Caulfield M, McCormack T ( 2011 ) . Authors’ reply to Harding and colleagues, Taylor, Cruickshank, and El Turabi and Payne . The BMJ vol. 343 , ( oct12 1 )

Wain LV, Verwoert GC, O'Reilly PF, Shi G, Johnson T, Munroe PB, Psaty BM, Caulfield MJ et al. ( 2011 ) . A large genome-wide association study of pulse pressure and mean arterial pressure reveals seven novel blood pressure LOCI . J HUM HYPERTENS vol. 25 , ( 10 ) 647 - 647 .

Lovibond K, Jowett S, Barton P, Caulfield M, Heneghan C, Hobbs FDR, Hodgkinson J, Mant J et al. ( 2011 ) . Cost-effectiveness of options for the diagnosis of high blood pressure in primary care: a modelling study . LANCET vol. 378 , ( 9798 ) 1219 - 1230 .

Michell AR, Bodey AR, Caulfield M ( 2011 ) . Evolution, essential hypertension and the high arterial pressures in certain athletic breeds of dogs (vol 188, pg 125, 2011) . VET J vol. 190 , ( 1 ) 184 - 184 .

Wain LV, Verwoert GC, O'Reilly PF, Shi G, Johnson T, Johnson AD, Bochud M, Rice KM et al. ( 2011 ) . Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure . NAT GENET vol. 43 , ( 10 ) 1005 - U122 .

Kooner JS, Saleheen D, Sim X, Sehmi J, Zhang WH, Frossard P, Been LF, Chia KS et al. ( 2011 ) . Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci . NAT GENET vol. 43 , ( 10 ) 984 - U94 .

McCarthy N, Vangjeli C, Surendran P, Treumann A, Rooney C, Ho E, Sever P, Thom S et al. ( 2011 ) . PPARGC1 beta is a genetic determinant of the cardiovascular risk factor, Thromboxane A2-an Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) sub-study . J HUM HYPERTENS vol. 25 , ( 10 ) 625 - 625 .

Patel S, Ng FL, Uddin I, Caulfield MJ, Lobo MD ( 2011 ) . Plasma renin activity in the South Asian population-an intermediate group . J HUM HYPERTENS vol. 25 , ( 10 ) 631 - 631 .

Patel S, Ng FL, Uddin I, Caulfield MJ, Lobo MD ( 2011 ) . Salt intake in hypertensive patients with at or above-target blood pressures . J HUM HYPERTENS vol. 25 , ( 10 ) 632 - 632 .

Ehret G, Munroe PB, Rice K, Bochud M, Johnson A, Chasman D, Vernon-Smith A, Psaty B et al. ( 2011 ) . Sixteen novel loci influence blood pressure and cardiovascular risk . J HUM HYPERTENS vol. 25 , ( 10 ) 635 - 636 .

International Consortium for Blood Pressure Genome-Wide Association Studies, Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV et al. ( 2011 ) . Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk . Nature vol. 478 , ( 7367 ) 103 - 109 .

Krause T, Lovibond K, Caulfield M, McCormack T, Williams B, Guideline Dev Grp ( 2011 ) . GUIDELINES Management of hypertension: summary of NICE guidance . BRIT MED J vol. 343 , Article d4891 ,

Putku M, Kepp K, Org E, Sõber S, Comas D, Viigimaa M, Veldre G, Juhanson P et al. ( 2011 ) . Novel polymorphic AluYb8 insertion in the WNK1 gene is associated with blood pressure variation in Europeans . Hum Mutat vol. 32 , ( 7 ) 806 - 814 .

Fox ER, Young JH, Li YL, Dreisbach AW, Keating BJ, Musani SK, Liu K, Morrison AC et al. ( 2011 ) . Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study . HUM MOL GENET vol. 20 , ( 11 ) 2273 - 2284 .

Fox ER, Young JH, Li Y, Dreisbach AW, Keating BJ, Musani SK, Liu K, Morrison AC et al. ( 2011 ) . Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study . Hum Mol Genet vol. 20 , ( 11 ) 2273 - 2284 .

Hughes R, Lovibond K, Caulfield M, Williams B ( 2011 ) . TREATING HYPERTENSION WITH FIRST-LINE THERAPIES IS CHEAPER THAN DOING NOTHING . Journal of Hypertension vol. 29 ,

Johnson AD, Newton-Cheh C, Chasman DI, Ehret GB, Johnson T, Rose L, Rice K, Verwoert GC et al. ( 2011 ) . Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals . Hypertension vol. 57 , ( 5 ) 903 - 910 .

Michell AR, Bodey AR, Caulfield M ( 2011 ) . Evolution, essential hypertension and the high arterial pressures in certain athletic breeds of dogs . VET J vol. 188 , ( 2 ) 125 - 127 .

Peden JF, Hopewell JC, Saleheen D, Chambers JC, Hager J, Soranzo N, Collins R, Danesh J et al. ( 2011 ) . A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease . NAT GENET vol. 43 , ( 4 ) 339 - U89 .

Collier DJ, Poulter NR, Dahlöf B, Sever PS, Wedel H, Buch J, Caulfield MJ, ASCOT Investigators ( 2011 ) . Impact of amlodipine-based therapy among older and younger patients in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA) . J Hypertens vol. 29 , ( 3 ) 583 - 591 .

Collier DJ, Poulter NR, Dahlöf B, Sever PS, Wedel H, Buch J, Caulfield MJ, ASCOT Investigators ( 2011 ) . Impact of atorvastatin among older and younger patients in the Anglo-Scandinavian Cardiac Outcomes Trial Lipid-Lowering Arm . J Hypertens vol. 29 , ( 3 ) 592 - 599 .

Lanktree MB, Guo YR, Murtaza M, Glessner JT, Bailey SD, Onland-Moret NC, Lettre G, Ongen H et al. ( 2011 ) . Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height . AM J HUM GENET vol. 88 , ( 1 ) 6 - 18 .

Chapman N, Chang CL, Caulfield M, Dahlof B, Feder G, Sever PS, Poulter NR ( 2011 ) . ETHNIC VARIATIONS IN LIPID-LOWERING IN RESPONSE TO A STATIN (EVIREST): A SUBSTUDY OF THE ANGLO-SCANDINAVIAN CARDIAC OUTCOMES TRIAL (ASCOT) . ETHNIC DIS vol. 21 , ( 2 ) 150 - 157 .

Esler MD, Krum H, Sobotka PA, Schlaich MP, Schmieder RE, Boehm M, Mahfoud F, Sievert H et al. ( 2010 ) . Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial . LANCET vol. 376 , ( 9756 ) 1903 - 1909 .

Sotoodehnia N, Isaacs A, de Bakker PIW, Dorr M, Newton-Cheh C, Nolte IM, van der Harst P, Muller M et al. ( 2010 ) . Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction . NAT GENET vol. 42 , ( 12 ) 1068 - U62 .

Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Lango Allen H, Lindgren CM et al. ( 2010 ) . Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index . Nat Genet vol. 42 , ( 11 ) 937 - 948 .

Tabara Y, Kohara K, Kita Y, Hirawa N, Katsuya T, Ohkubo T, Hiura Y, Tajima A et al. ( 2010 ) . Common variants in the ATP2B1 gene are associated with susceptibility to hypertension: the Japanese Millennium Genome Project . Hypertension vol. 56 , ( 5 ) 973 - 980 .

Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, Thorleifsson G, Zillikens MC et al. ( 2010 ) . Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution . Nat Genet vol. 42 , ( 11 ) 949 - 960 .

Padmanabhan S, Melander O, Johnson T, Di Blasio AM, Lee WK, Gentilini D, Hastie CE, Menni C et al. ( 2010 ) . Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension . PLoS Genet vol. 6 , ( 10 )

Allen HL, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F, Willer CJ, Jackson AU et al. ( 2010 ) . Hundreds of variants clustered in genomic loci and biological pathways affect human height . NATURE vol. 467 , ( 7317 ) 832 - 838 .

Johnson T, Shaw-Hawkins S, Howard P, Lathrop M, Stanton A, Shields D, Poulter N, Sever P et al. ( 2010 ) . A novel gene locus for blood pressure variability identified by genomewide association scanning in the Anglo-Scandinavian Cardiac Outcome Trial . J HUM HYPERTENS vol. 24 , ( 10 ) 694 - 694 .

Hastie CE, Padmanabhan S, Melander O, Johnson T, Di Blasio AM, Munroe PB, Caulfield M, Zanchetti A et al. ( 2010 ) . Genome wide association study of blood pressure extremes identifies variant in uromodulin gene associated with hypertension . J HUM HYPERTENS vol. 24 , ( 10 ) 687 - 687 .

Collier DJ, Robson J, Scott R, Will CM, Eldridge SE, Griffiths CJ, Badrick E, Saxena M et al. ( 2010 ) . HiLo: a health services intervention study: methods and interim results on the first 2000 patients at 1 year . J HUM HYPERTENS vol. 24 , ( 10 ) 708 - 709 .

Gupta AK, Poulter NR, Dobson J, Eldridge S, Cappuccio FP, Caulfield M, Collier D, Cruickshank JK et al. ( 2010 ) . Ethnic Differences in Blood Pressure Response to First and Second-Line Antihypertensive Therapies in Patients Randomized in the ASCOT Trial . AM J HYPERTENS vol. 23 , ( 9 ) 1023 - 1030 .

Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP, Ripatti S et al. ( 2010 ) . Biological, clinical and population relevance of 95 loci for blood lipids . NATURE vol. 466 , ( 7307 ) 707 - 713 .

Caulfield M ( 2010 ) . The 10 minute clinical assessment . Gut vol. 59 , ( 9 )

Dolan E, Caulfield M, Thom S, McInnes G, Collier D, O'Brien E, Stanton A ( 2010 ) . AMBULATORY ARTERIAL STIFFNESS INDEX PREDICTS CARDIOVASCULAR MORBIDITY AND MORTALITY IN TREATED HYPERTENSIVE PATIENTS - AN ANGLO - SCANDINAVIAN CARDIAC OUTCOME TRIAL SUB-STUDY . JOURNAL OF HYPERTENSION . vol. 28 , E13 - E14 .

Padmanabhan S, Melander O, Johnson T, Di Blasio AM, Lee WK, Navis G, Bochud M, Munroe PB et al. ( 2010 ) . GENOME WIDE ASSOCIATION STUDY OF BLOOD PRESSURE EXTREMES IDENTIFIES VARIANT IN UMOD ASSOCIATED WITH HYPERTENSION . JOURNAL OF HYPERTENSION . vol. 28 , E237 - E237 .

Alvarez-Madrazo S, Padmanabhan S, Friel E, MacKenzie SM, Brown MJ, Caulfield MJ, Munroe PB, Farrall M et al. ( 2010 ) . Validation of Association of Hypertension at the CYP11B1/B2 Locus in Caucasians . ENDOCRINE REVIEWS . vol. 31 ,

Mancia G, Laurent S, Agabiti-Rosei E, Ambrosioni E, Burnier M, Caulfield MJ, Cifkova R, Clément D et al. ( 2010 ) . European guidelines on the management of hypertension: The European Society of Hypertension position statement (2009) . Nadcisnienie Tetnicze vol. 14 , ( 1 ) 1 - 47 .

Chambers JC, Zhang WH, Lord GM, van der Harst P, Lawlor DA, Sehmi JS, Gale DP, Wass MN et al. ( 2010 ) . Genetic loci influencing kidney function and chronic kidney disease . NAT GENET vol. 42 , ( 5 ) 373 - 375 .

Liu JZ, Tozzi F, Waterworth DM, Pillai SG, Muglia P, Middleton L, Berrettini W, Knouff CW et al. ( 2010 ) . Meta-analysis and imputation refines the association of 15q25 with smoking quantity . NAT GENET vol. 42 , ( 5 ) 436 - U75 .

Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, Qi L, Speliotes EK, Thorleifsson G et al. ( 2010 ) . Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution . PLOS GENET vol. 6 , ( 4 ) Article e1000508 ,

Craddock N, Hurles ME, Cardin N, Pearson RD, Plagnol V, Robson S, Vukcevic D, Barnes C et al. ( 2010 ) . Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls . NATURE vol. 464 , ( 7289 ) 713 - U86 .

van der Harst P, Bakker SJL, de Boer RA, Wolffenbuttel BHR, Johnson T, Caulfield MJ, Navis G ( 2010 ) . Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms . HUM MOL GENET vol. 19 , ( 2 ) 387 - 395 .

Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J et al. ( 2009 ) . Gene-centric Association Signals for Lipids and Apolipoproteins Identified via the HumanCVD BeadChip . AM J HUM GENET vol. 85 , ( 5 ) 628 - 642 .

Munroe PB, Johnson T, Caulfield MJ ( 2009 ) . The genetic architecture of blood pressure variation . Current Cardiovascular Risk Reports vol. 3 , ( 6 )

Mancia G, Laurent S, Agabiti-Rosei E, Ambrosioni E, Burnier M, Caulfield MJ, Cifkova R, Clement D et al. ( 2009 ) . Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document . J HYPERTENS vol. 27 , ( 11 ) 2121 - 2158 .

Vidyarthi M, Balakumar Y, Perry I, Berney D, Bhattacharya S, Lobo M, Rull G, Drake WM et al. ( 2009 ) . Hypokalaemic hypertension due to a rare cause . J HUM HYPERTENS vol. 23 , ( 10 ) 698 - 698 .

Dobson RJB, Munroe PB, Caulfield MJ, Saqi MAS ( 2009 ) . Global sequence properties for superfamily prediction: a machine learning approach . Journal of Integrative Bioinformatics vol. 6 , ( 1 )

Caulfield M ( 2009 ) . Atheromatous vascular disease and ischaemic stroke in the UK . J DENT vol. 37 , ( 8 ) S579 - S581 .

Caulfield M ( 2009 ) . PREDICTION OF ANTIHYPERTENSIVE RESPONSE - GENOTYPE . BASIC CLIN PHARMACOL vol. 105 , 11 - 11 .

Nolte IM, Wallace C, Newhouse SJ, Waggott D, Fu J, Soranzo N, Gwilliam R, Deloukas P et al. ( 2009 ) . Common Genetic Variation Near the Phospholamban Gene Is Associated with Cardiac Repolarisation: Meta-Analysis of Three Genome-Wide Association Studies . PLOS ONE vol. 4 , ( 7 )

Sõber S, Org E, Kepp K, Juhanson P, Eyheramendy S, Gieger C, Lichtner P, Klopp N et al. ( 2009 ) . Targeting 160 Candidate Genes for Blood Pressure Regulation with a Genome-Wide Genotyping Array . PLOS ONE vol. 4 , ( 6 )

Org E, Eyheramendy S, Juhanson P, Gieger C, Lichtner P, Klopp N, Veldre G, Doring A et al. ( 2009 ) . Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations . HUM MOL GENET vol. 18 , ( 12 ) 2288 - 2296 .

Caulfield MJ, Bochud M, Global BP Gen ( 2009 ) . EIGHT BLOOD PRESSURE LOCI IDENTIFIED BY A GENOME-WIDE ASSOCIATION STUDY OF 34,433 PEOPLE OF EUROPEAN ANCESTRY . JOURNAL OF HYPERTENSION . vol. 27 , S167 - S167 .

Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, Qi L, Speliotes EK, Thorleifsson G et al. ( 2009 ) . Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution . PLOS GENET vol. 5 , ( 6 ) Article e1000508 ,

Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L, Najjar SS, Zhao JH et al. ( 2009 ) . Genome-wide association study identifies eight loci associated with blood pressure . NAT GENET vol. 41 , ( 6 ) 666 - 676 .

Kolz M, Johnson T, Sanna S, Teumer A, Vitart V, Perola M, Mangino M, Albrecht E et al. ( 2009 ) . Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations . PLOS GENET vol. 5 , ( 6 ) Article e1000504 ,

Newhouse S, Farrall M, Wallace C, Hoti M, Burke B, Howard P, Onipinla A, Lee K et al. ( 2009 ) . Polymorphisms in the WNK1 Gene Are Associated with Blood Pressure Variation and Urinary Potassium Excretion . PLOS ONE vol. 4 , ( 4 ) Article e5003 ,

Dolan E, Stanton AV, Thom S, Caulfield M, Atkins N, McInnes G, Collier D, Dicker P et al. ( 2009 ) . Ambulatory blood pressure monitoring predicts cardiovascular events in treated hypertensive patients - an Anglo-Scandinavian cardiac outcomes trial substudy . J HYPERTENS vol. 27 , ( 4 ) 876 - 885 .

Collier DJ, Stride TJ, He S, Wilson SL, Shiel JI, Caulfield MJ ( 2009 ) . Impact of Lifestyle Changes During Five Years of Drug Treatment in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) . JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY . vol. 53 , A215 - A215 .

Mancia G, Laurent S, Agabiti-Rosei E, Ambrosioni E, Burnier M, Caulfield MJ, Cifkova R, Clement D et al. ( 2009 ) . Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document . BLOOD PRESSURE vol. 18 , ( 6 ) 308 - 347 .

Willer CJ, Speliotes EK, Loos RJF, Li SX, Lindgren CM, Heid IM, Berndt SI, Elliott AL et al. ( 2009 ) . Six new loci associated with body mass index highlight a neuronal influence on body weight regulation . NAT GENET vol. 41 , ( 1 ) 25 - 34 .

JENKINS BJ, CAULFIELD MJ, FOWLER CG, BADENOCH DF, TIPTAFT RC, PARIS AMI, HOPE‐STONE HF, OLIVER RTD et al. ( 2008 ) . Reappraisal of the Role of Radical Radiotherapy and Salvage Cystectomy in the Treatment of Invasive (T2/T3) Bladder Cancer . BJU International vol. 62 , ( 4 ) 343 - 346 .

Ostergren J, Poulter NR, Sever PS, Dahlof B, Wedel H, Beevers G, Caulfield M, Collins R et al. ( 2008 ) . The Anglo-Scandinavian Cardiac Outcomes Trial: blood pressure-lowering limb: effects in patients with type II diabetes . J HYPERTENS vol. 26 , ( 11 ) 2103 - 2111 .

Samani NJ, Braund PS, Erdmann J, Gotz A, Tomaszewski M, Linsel-Nitschke P, Hajat C, Mangino M et al. ( 2008 ) . The novel genetic variant predisposing to coronary artery disease in the region of the PSRC1 and CELSR2 genes on chromosome 1 associates with serum cholesterol . J MOL MED-JMM vol. 86 , ( 11 ) 1233 - 1241 .

Keating BJ, Tischfield S, Murray SS, Bhangale T, Price TS, Glessner JT, Galver L, Barrett JC et al. ( 2008 ) . Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies . PLOS ONE vol. 3 , ( 10 ) Article e3583 ,

Gupta AK, Poulter NR, Eldridge S, Cappuccio FP, Caulfield MJ, Dobson J, Cruickshank JK, Griffiths CJ et al. ( 2008 ) . Ethnic differences in blood pressure response to atenolol and amlodipine monotherapy and to add on diuretic and ACE inhibitor dual therapy in hypertensive patients from UK in ASCOT-BPLA . J HUM HYPERTENS vol. 22 , ( 10 ) 726 - 727 .

Huq SM, Oldapo MNJ, Wang Y, Li J, Loo RL, Braund P, Tobin M, Barton P et al. ( 2008 ) . High glucose and low lactate: a metabolic signature of hypertension in human serum? . HYPERTENSION . vol. 52 , 758 - 759 .

Caulfield MJ, Munroe PB, O'Neill D, Witkowska K, Charchar FJ, Doblado M, Evans S, Eyheramendy S et al. ( 2008 ) . SLC2A9 Is a High-Capacity Urate Transporter in Humans . PLOS MED vol. 5 , ( 10 ) Article E197 , 1509 - 1523 .

Brown MJ, Newhouse S, Wallace C, Marcano AC, Shaw-Hawkins S, Howard P, Onipinla A, Dobson R et al. ( 2008 ) . Systematic analysis of 123 candidate genes reveals two novel genes for hypertension . HYPERTENSION . vol. 52 , 764 - 765 .

Hoti M, Newhouse S, Clayton D, Samani NJ, Dominiczak AF, Brown MJ, Webster J, Lathrop M et al. ( 2008 ) . WNK1 - functional analyses of variants associated with blood pressure and essential hypertension . J HUM HYPERTENS . vol. 22 , 722 - 722 .

Hoti M, Newhouse S, Clayton D, Samani NJ, Dominiczak AF, Brown MJ, Webster J, Lathrop M et al. ( 2008 ) . WNK1-functional analyses of variants associated with blood pressure and essential hypertension . HYPERTENSION . vol. 52 , 764 - 764 .

Delles C, Padmanabhan S, Lee WK, Miller WH, McBride MW, McClure JD, Brain NJ, Wallace C et al. ( 2008 ) . Glutathione S-transferase variants and hypertension . J HYPERTENS vol. 26 , ( 7 ) 1343 - 1352 .

Tobin MD, Tomaszewski M, Braund PS, Hajat C, Raleigh SM, Palmer TM, Caulfield M, Burton PR et al. ( 2008 ) . Common variants in genes underlying monogenic hypertension and hypotension and blood pressure in the general population . HYPERTENSION vol. 51 , ( 6 ) 1658 - 1664 .

Tomaszewski M, Tobin MD, Braund PS, Hajat C, Raleigh SM, Palmer TM, Caulfield M, Burton PR et al. ( 2008 ) . Common variants in the gene underlying type 2 Bartter syndrome are associated with blood pressure in the general population - The results of the genetic scan in the GRAPHIC (genetic regulation of arterial pressure of humans in the community) study . JOURNAL OF HYPERTENSION . vol. 26 , S12 - S12 .

Loos RJF, Lindgren CM, Li SX, Wheeler E, Zhao JH, Prokopenko I, Inouye M, Freathy RM et al. ( 2008 ) . Common variants near MC4R are associated with fat mass, weight and risk of obesity . NAT GENET vol. 40 , ( 6 ) 768 - 775 .

Weedon MN, Lango H, Lindgren CM, Wallace C, Evans DM, Mangino M, Freathy RM, Perry JRB et al. ( 2008 ) . Genome-wide association analysis identifies 20 loci that influence adult height . NAT GENET vol. 40 , ( 5 ) 575 - 583 .

Johnston L, Caulfield M, Savage M, Clark A ( 2008 ) . NESTEGG: detecting new genes that influence fetal and childhood growth . Acta Paediatrica vol. 88 , ( s433 ) 143 - 147 .

Sever PS, Poulter NR, Dahlof B, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE et al. ( 2008 ) . The Anglo-Scandinavian Cardiac Outcomes Trial lipid lowering arm: extended observations 2 years after trial closure . EUR HEART J vol. 29 , ( 4 ) 499 - 508 .

Johnston L, Ester W, Koelega AH, Ranke M, Caliebe J, Caulfield M, Tauber M, Molinas C et al. ( 2008 ) . Analysis of GDF5-UQCC polymorphism with height in NESTEGG SGA and ISS subjects . HORM RES vol. 70 , 90 - 90 .

Dobson RJB, Munroe PB, Mein CA, Caulfield MJ, Saqi MAS ( 2008 ) . Combining protein-protein interaction (PPI) network and sequence attributes for predicting hypertension related proteins . BIOINFORMATICS RESEARCH AND DEVELOPMENT, PROCEEDINGS . Editors: Elloumi, M, Kung, J, Linial, M, Murphy, RF et al. , vol. 13 , 377 - 391 .

Doblado M, Munroe PB, O'Neill D, Witkowska K, Charchar F, Evans S, Caulfield MJ, Cheeseman CI et al. ( 2008 ) . Functional studies identify a glucose transporter SLC2A9 as a novel urate transporter . DIABETES . vol. 57 , A356 - A356 .

Wallace C, Newhouse SJ, Braund P, Zhang F, Tobin M, Falchi M, Ahmadi K, Dobson RJ et al. ( 2008 ) . Genome-wide association study identifies genes for biomarkers of cardiovascular disease: Serum urate and dyslipiclemia . AM J HUM GENET vol. 82 , ( 1 ) 139 - 149 .

Freel EM, Ingram M, Friel EC, Fraser R, Brown M, Samani NJ, Caulfield M, Munroe P et al. ( 2007 ) . Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study . CLIN ENDOCRINOL vol. 67 , ( 6 ) 832 - 838 .

Wallace C, Newhouse SJ, Braund P, Zhang F, Tobin M, Falchi M, Ahmadi K, Dobson RJ et al. ( 2007 ) . Discovery of novel genes for serum urate and low-density lipoprotein cholesterol - Two biomarkers of cardiovascular disease . CIRCULATION RESEARCH . vol. 101 , 1208 - 1208 .

Newhouse SJ, Wallace C, Hoti M, Dobson RJ, Farrall M, Brown M, Samani NJ, Dominiczak A et al. ( 2007 ) . Novel associations of the Wnk1 gene with risk for essential hypertension and electrolyte homeostasis . CIRCULATION RESEARCH . vol. 101 , 1208 - 1208 .

Barter PJ, Caulfield M, Eriksson M, Grundy SM, Kastelein JJP, Komajda M, Lopez-Sendon J, Mosca L et al. ( 2007 ) . Effects of torcetrapib in patients at high risk for coronary events . NEW ENGL J MED vol. 357 , ( 21 ) 2109 - 2122 .

Thomson W, Barton A, Ke X, Eyre S, Hinks A, Bowes J, Donn R, Symmons D et al. ( 2007 ) . Rheumatoid arthritis association at 6q23 . Nature Genetics vol. 39 , ( 12 ) 1431 - 1433 .

Newport M, Sirugo G, Lyons E, Vannberg F, Hill AVS, Bradbury LA, Farrar C, Pointon JJ et al. ( 2007 ) . Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants . NAT GENET vol. 39 , ( 11 ) 1329 - 1337 .

HITMAN GA, Todd JA, Samani NJ, Ouwehand WH, Kwiatkowski DP, Deloukas P, Craddock N, Cardon LR et al. ( 2007 ) . Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants . Nat Genet vol. 39 , 129 - 1337 .

Wallace C, Dobson RJ, Munroe PB, Caulfield MJ ( 2007 ) . Information capture using SNPs from HapMap and whole-genome chips differs in a sample of inflammatory and cardiovascular gene-centric regions from genome-wide estimates . Genome Res vol. 17 , ( 11 ) 1596 - 1602 .

Padmanabhan S, Davies E, MacKenzie SM, Lim W, Barr M, Friel EC, Munroe PB, Brown MJ et al. ( 2007 ) . Association of the CYP11B1 and CYP11B2 gene polymorphisms with hypertension in the British Genetics of Hypertension case-control study . J HUM HYPERTENS vol. 21 , ( 10 ) 837 - 837 .

Newhouse S, Wallace C, Hoti M, Burke B, Marcano A, Onipinla A, Dobson R, Mein C et al. ( 2007 ) . Association of the WNK1 gene with essential hypertension, blood pressure variability and serum and urine electrolytes . J HUM HYPERTENS . vol. 21 , 831 - 831 .

Collier DJ, Davies LC, Bernardi L, Sleight P, Misra S, Shiel J, David CM, Scott B et al. ( 2007 ) . Baroreceptor function changes with differing blood pressure treatment during the anglo-scandinavian cardiac outcomes trial: principal results from the cardiac autonomic reflex assessment trial (CARAT) . J HUM HYPERTENS vol. 21 , ( 10 ) 846 - 847 .

Padmanabhan S, Menni C, Delles C, Munroe PB, Brown MJ, Samani NJ, Farrall M, Dobson R et al. ( 2007 ) . Urinary albumin excretion in hypertensive siblings in the British Genetics of Hypertension study . J HUM HYPERTENS . vol. 21 , 843 - 843 .

Marcano ACB, Burke B, Gungadoo J, Wallace C, Kaisaki PJ, Woon PY, Farrall M, Clayton D et al. ( 2007 ) . Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension . J MED GENET vol. 44 , ( 9 ) Article 603 ,

Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, Kwiatkowski DP, McCarthy MI et al. ( 2007 ) . Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls . NATURE vol. 447 , ( 7145 ) 661 - 678 .

Collier D, Davies L, Bernardi L, Sleight P, Shiel J, Patel N, Misra S, Martin T et al. ( 2007 ) . Baroreceptor function changes with differing blood pressure treatment during the Anglo-Scandinavian Cardiac Outcomes Trial: Principal results from the Cardiac Autonomic Reflex Assessment Trial (CARAT) . JOURNAL OF HYPERTENSION . vol. 25 , S292 - S292 .

Collier D, Arunachalam G, Johnston A, Richards S, Shiel J, Wells Z, David C, Caulfield M ( 2007 ) . Continuing reduction of microalbuminuria and proteinuria during follow-up for the Anglo-Scandinavian Cardiac Outcomes Trial dominance of duration and blood pressure over other effects . JOURNAL OF HYPERTENSION . vol. 25 , S150 - S150 .

Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JRB et al. ( 2007 ) . Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes . Science vol. 316 , ( 5829 ) 1336 - 1341 .

Brown M, Boon N, Brooks N, Camm J, Corris P, Caulfield M, Chilvers E, Ewan P et al. ( 2007 ) . Medical training in the UK: sleepwalking to disaster . The Lancet vol. 369 , ( 9574 ) 1673 - 1675 .

( 2007 ) . Babies, pre-eclamptic mothers and grandparents: a three-generation phenotyping study . Journal of Hypertension vol. 25 , ( 4 ) 849 - 854 .

Brown M, Boon N, Brooks N, Brown E, Camm J, Caulfield M, Chilvers E, Gibson J et al. ( 2007 ) . Modernising Medical Careers, Medical Training Application Service, and the Postgraduate Medical Education and Training Board: time for the emperors to don their clothes . LANCET vol. 369 , ( 9566 ) 967 - 968 .

Burke B, Gungadoo J, Marçano ACB, Newhouse SJ, Shiel J, Caulfield MJ, Munroe PB ( 2007 ) . Chapter 36 Monogenic Forms of Human Hypertension . Comprehensive Hypertension , Elsevier

Burke B, Gungadoo J, Marçano ACB, Newhouse SJ, Shiel J, Caulfield MJ, Munroe PB ( 2007 ) . Monogenic Forms of Human Hypertension . Comprehensive Hypertension ,

Barr M, MacKenzie SM, Friel EC, Holloway CD, Wilkinson DM, Brain NJR, Ingram MC, Fraser R et al. ( 2007 ) . Polymorphic variation in the 11 beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency . HYPERTENSION vol. 49 , ( 1 ) 113 - 119 .

CAULFIELD M, BOULOUX P, MUNROE P ( 1997 ) . Progress in Determining the Genes for Hypertension, Insulin Resistance, and Dyslipidemiaa . Annals of the New York Academy of Sciences . vol. 827 , 110 - 117 .

Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G, Grassi G, Heagerty AM et al. ( 2006 ) . 2007 Guidelines for the management of arterial hypertension The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC) . European Heart Journal vol. 28 , ( 12 ) 1462 - 1536 .

Sever P, Dahlöf B, Poulter N, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen S et al. ( 2006 ) . Potential synergy between lipid-lowering and blood-pressure-lowering in the Anglo-Scandinavian Cardiac Outcomes Trial . European Heart Journal vol. 27 , ( 24 ) 2982 - 2988 .

Collier DJ, Caulfield MJ, Poulter NR, Dahlof B, Wedel H, Sever PS ( 2006 ) . Did older or younger patients benefit more from amlodipine based vs atenolol based therapy in ASCOT-BPLA? . CIRCULATION . vol. 114 , 896 - 896 .

Delles C, Braga-Marcano AC, Munroe PB, Padmanabhan S, McClure JD, Brain NJ, Brown MJ, Samani NJ et al. ( 2006 ) . Association between variants of the human GSTM gene family and hypertension . HYPERTENSION . vol. 48 , E27 - E27 .

Padmanabhan S, Hastie CE, Wallace C, Munroe PB, Dobson R, Brown M, Samani NJ, Clayton D et al. ( 2006 ) . Familial atherosclerotic disease and hypertension localised to chromosome 7p in the British genetics of hypertension study . HYPERTENSION . vol. 48 , E98 - E98 .

Ostergren J, Sever P, Poulter N, Dahlof B, Wedel H, Beevers G, Caulfield M, Collins R et al. ( 2006 ) . The Anglo-Scandinavian Cardiac Outcomes Trial: Blood pressure-lowering limb (ASCOT-BPLA): effects in patients with type 2 diabetes . DIABETOLOGIA . vol. 49 , 136 - 137 .

Wallace C, Xue M-Z, Newhouse SJ, Marcano ACB, Onipinla AK, Burke B, Gungadoo J, Dobson RJ et al. ( 2006 ) . Linkage analysis using co-phenotypes in the BRIGHT study reveals novel potential susceptibility loci for hypertension . Am J Hum Genet vol. 79 , ( 2 ) 323 - 331 .

Munroe PB, Wallace C, Xue M-Z, Marçano ACB, Dobson RJ, Onipinla AK, Burke B, Gungadoo J et al. ( 2006 ) . Increased support for linkage of a novel locus on chromosome 5q13 for essential hypertension in the British Genetics of Hypertension Study . Hypertension vol. 48 , ( 1 ) 105 - 111 .

( 2006 ) . Corrigendum . European Heart Journal vol. 28 , ( 1 ) 142 - 142 .

Padmanabhan S, Wallace C, McBride MW, Munroe PB, Dobson R, Brown M, Samani NJ, Clayton D et al. ( 2006 ) . Genomewide linkage analysis for loci affecting electrocardiographic LV mass . JOURNAL OF HYPERTENSION . vol. 24 , S330 - S330 .

Delles C, Marcano ACB, Munroe PB, Padmanabhan S, McClure JD, Brain NJ, Brown MJ, Samani NJ et al. ( 2006 ) . Variants of the human mu type glutathione-s-transferase (GSTM) gene family are associated with hypertension . JOURNAL OF HYPERTENSION . vol. 24 , S13 - S13 .

Dobson RJ, Munroe PB, Caulfield MJ, Saqi MA ( 2006 ) . Predicting deleterious nsSNPs: an analysis of sequence and structural attributes . BMC Bioinformatics vol. 7 ,

Bell JT, Wallace C, Dobson R, Wiltshire S, Mein C, Pembroke J, Brown M, Clayton D et al. ( 2006 ) . Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension . HUM MOL GENET vol. 15 , ( 8 ) 1365 - 1374 .

Padmanabhan S, Wallace C, Munroe PB, Dobson R, Brown M, Samani N, Clayton D, Farrall M et al. ( 2006 ) . Chromosome 2p shows significant linkage to antihypertensive response in the British Genetics of Hypertension Study . Hypertension . vol. 47 , 603 - 608 .

Padmanabhan S, Wallace C, Munroe PB, Dobson R, Brown M, Samani N, Clayton D, Farrall M et al. ( 2006 ) . Chromosome 2p shows significant linkage to antihypertensive response in the British genetics of hypertension study . HYPERTENSION . vol. 47 , 603 - 608 .

Binder A, Garcia E, Wallace C, Kazeem G, Ben-Shlomo Y, Yarnell J, Brown P, Caulfield M et al. ( 2006 ) . Haplotypes of the beta-2 adrenergic receptor associate with high diastolic blood pressure in the Caerphilly prospective study . J HYPERTENS vol. 24 , ( 3 ) 471 - 477 .

Tobin MD, Raleigh SM, Newhouse S, Braund P, Bodycote C, Ogleby J, Cross D, Gracey J et al. ( 2005 ) . Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population . CIRCULATION vol. 112 , ( 22 ) 3423 - 3429 .

Padmanabhan S, Wallace C, Munroe PB, Brown M, Samani N, Clayton D, Farrall M, Webster J et al. ( 2005 ) . Chromosome 2p shows genome wide significant linkage to of anti-hypertensive medication response in the British genetics of hypertension (BRIGHT) study . HYPERTENSION . vol. 46 , 886 - 886 .

Wallace C, Xue MZ, Dobson R, Marcano C, Gungadoo J, Burke B, Onipinla A, Newhouse S et al. ( 2005 ) . Loci on chromosomes 5p and 20q are linked to multiple hypertension phenotypes in the BRItish genetics of Hypertension (BRIGHT) study . HYPERTENSION . vol. 46 , 877 - 877 .

Padmanabhan S, Munroe PB, Brown M, Clayton D, Farrall M, Webster J, Lathrop M, Caulfield M et al. ( 2005 ) . Chromosome 2p shows genome wide significant linkage to anti-hypertensive medication response in the British genetics hypertension (BRIGHT) study . HYPERTENSION . vol. 46 , 886 - 886 .

Munroe PB, Wallace C, Mein C, Dobson R, Xue M, Marcano C, Burke B, Gungadoo J et al. ( 2005 ) . Enhanced support for linkage to chromosome 5q13.1 and hypertension in the British Genetics of Hypertension (BRIGHT) study . HYPERTENSION . vol. 46 , 892 - 892 .

Wallace C, Xue MZ, Dobson R, Marcano C, Gungadoo J, Burke B, Onipinla A, Newhouse S et al. ( 2005 ) . Loci on chromosomes 5p and 20q are linked to multiple hypertension phenotypes in the BRItish Genetics of HyperTension (BRIGHT) study . HYPERTENSION . vol. 46 , 877 - 877 .

Xue MZ, Wallace C, Dobson R, Garcia E, Kazeem G, Gardener G, Needham E, Mattu R et al. ( 2005 ) . Variants and haplotypes of the angiotensinogen gene are associated with hypertension in the Caerphilly Prospective Study . HYPERTENSION . vol. 46 , 904 - 904 .

Dahlof B, Sever PS, Poulter NR, Wedel H, Beevers DG, Caulfield M, Collins R, Kjeldsen SE et al. ( 2005 ) . Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial . LANCET vol. 366 , ( 9489 ) 895 - 906 .

Poulter NR, Wedel H, Dahlof B, Sever PS, Beevers DG, Caulfield M, Kjeldsen SE, Kristinsson A et al. ( 2005 ) . Role of blood pressure and other variables in the differential cardiovascular event rates noted in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA) . LANCET vol. 366 , ( 9489 ) 907 - 913 .

( 2005 ) . Epidemiology of Hypertension . Hypertension , Taylor & Francis

Newhouse SJ, Wallace C, Dobson R, Mein C, Pembroke J, Farrall M, Clayton D, Brown M et al. ( 2005 ) . Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study . Hum Mol Genet vol. 14 , ( 13 ) 1805 - 1814 .

Marcano ACB, Onipinla AK, Caulfield MJ, Munroe PB ( 2005 ) . Recent advances in the identification of genes for human hypertension . Expert Rev Cardiovasc Ther vol. 3 , ( 4 ) 733 - 741 .

Consortium G ( 2005 ) . Disentangling Fetal and Maternal Susceptibility for Pre-Eclampsia: A British Multicenter Candidate-Gene Study . American Journal of Human Genetics vol. 77 , ( 1 ) 127 - 131 .

Sever PS, Poulter NR, Dahlof B, Wedel H, Collins R, Beevers G, Caulfield M, Kjeldsen SE et al. ( 2005 ) . Reduction in cardiovascular events with atorvastatin in 2,532 patients with type 2 diabetes: Anglo-Scandinavian Cardiac Outcomes Trial-Lipid-Lowering Arm (ASCOT-LLA) . DIABETES CARE vol. 28 , ( 5 ) 1151 - 1157 .

Mein CA, Caulfield MJ, Munroe PB ( 2005 ) . Selection of candidate genes in hypertension . vol. 108 ,

Munroe PB, Dobson R, Pembroke J, Wilson S, Pheby J, Colville-Stewart S, Gilmour K, Macdade M et al. ( 2004 ) . The MRC BRIGHT study: Demographic and biochemical characteristics of the sibling-pair resource . BRITISH JOURNAL OF CLINICAL PHARMACOLOGY . vol. 58 , 688 - 688 .

Lee YW, Oh VMS, Garcia E, Taylor EA, Wu HM, Yap EPH, Kazeem GR, Caulfield MJ et al. ( 2004 ) . Haplotypes of the beta 2-adrenegic receptor gene are associated with essential hypertension in a Singaporean Chinese population . J HYPERTENS vol. 22 , ( 11 ) 2111 - 2116 .

Newhouse S, Dobson R, Wallace C, Pembroke J, Garcia E, Mein C, Clayton D, Samani N et al. ( 2004 ) . No association of the WNK1 gene with essential hypertension in the MRC BRIGHT study . JOURNAL OF HYPERTENSION . vol. 22 , S212 - S212 .

Mein CA, Caulfield MJ, Dobson RJ, Munroe PB ( 2004 ) . Genetics of essential hypertension . Human Molecular Genetics vol. 13 , ( REV. ISS. 1 )

Mein CA, Caulfield MJ, Dobson RJ, Munroe PB ( 2004 ) . Genetics of essential hypertension . Hum Mol Genet vol. 13 Spec No 1 , R169 - R175 .

Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE et al. ( 2004 ) . Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial - Lipid lowering arm (ASCOT-LLA): A multicentre randomised controlled trial . DRUGS . vol. 64 , 43 - 60 .

Caulfield M, Munroe P, Pembroke J, Study. FTMBGOH ( 2003 ) . Genome-wide mapping of human loci for essential hypertension . ACC Current Journal Review vol. 12 , ( 5 ) 32 - 33 .

Newhouse SJ, Garcia E, Caulfield M, Munroe P ( 2003 ) . Haplotype structure of the WNK1 gene and association studies in hypertensive populations . BRITISH JOURNAL OF CLINICAL PHARMACOLOGY . vol. 56 , 245 - 245 .

Kübler W ( 2003 ) . Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesteroal concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial—Lipid Lowering Arm (ASCOL-LLA): a multicentre randomised controlled trial . Clinical Research in Cardiology vol. 92 , ( 7 ) 613 - 613 .

Wilson S, Johnston A, Robson J, Poulter N, Collier D, Feder G, Caulfield MJ ( 2003 ) . Comparison of methods to identify individuals at increased risk of coronary disease from the general population . BMJ vol. 326 , ( 7404 )

Caulfield M, Munroe P, Pembroke J, Samani N, Dominiczak A, Brown M, Benjamin N, Webster J et al. ( 2003 ) . Genome-wide mapping of human loci for essential hypertension . Lancet vol. 361 , ( 9375 ) 2118 - 2123 .

Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE et al. ( 2003 ) . Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial . LANCET vol. 361 , ( 9364 ) 1149 - 1158 .

Wilson S, Johnston A, Collier DJ, Caulfield M ( 2003 ) . Feasibility of enrolling patients to hypertension outcome trials based on an assessment of their cardiovascular risk . BRITISH JOURNAL OF CLINICAL PHARMACOLOGY . vol. 55 , 425 - 426 .

Wilson S, Johnston A, Robson J, Poulter NR, Collier DJ, Feder GS, Caulfield MJ ( 2003 ) . Predicting coronary risk in the general population--is it necessary to measure high-density lipoprotein cholesterol? . J Cardiovasc Risk vol. 10 , ( 2 ) 137 - 141 .

Knight J, Munroe PB, Pembroke JC, Caulfield MJ ( 2003 ) . Human chromosome 17 in essential hypertension . Ann Hum Genet vol. 67 , ( Pt 2 ) 193 - 206 .

Garcia EA, Newhouse S, Caulfield MJ, Munroe PB ( 2003 ) . Genes and hypertension . Curr Pharm Des vol. 9 , ( 21 ) 1679 - 1689 .

Garcia EA, Aristizabal D, McEwen J, Mendez J, Munroe P, Caulfield M ( 2002 ) . Guanine nucleotide binding 3 (GNB3) haplotype analysis in the Venecia-Colombia Latin-American blood pressure study . AMERICAN JOURNAL OF HUMAN GENETICS . vol. 71 , 366 - 366 .

Wilson S, Johnston A, Robson J, Poulter N, Collier D, Feder G, Caulfield M ( 2002 ) . Should we measure high density lipoprotein cholesterol in people with hypertension? . JOURNAL OF HYPERTENSION . vol. 20 , S150 - S150 .

Caulfield M, Pembroke J, Dominiczak A, Samani N, Brown M, Clayton D, Ratcliffe P, Lathrop M et al. ( 2002 ) . The MRC British Genetics of Hypertension Study - Genome-wide screen results . JOURNAL OF HYPERTENSION . vol. 20 , S7 - S7 .

Wilson S, Johnston A, Robson J, Poulter N, Collier D, Feder G, Caulfield M ( 2002 ) . OR-4: Who should have their cholesterol measured? A comparison of selective cholesterol screening methods . American Journal of Hypertension vol. 15 , ( S3 ) 2a - 2a .

Collier DJ, Martin TA, Angell-James JE, Bernardi L, Sleight P, Caulfield MJ ( 2002 ) . P-334: Gender differences in carotid sinus baroreceptor reflexes in healthy young normal subjects and in ASCOT patients with treated essential hypertension . American Journal of Hypertension vol. 15 , ( S3 ) 151a - 151a .

Chapman JN, Kirby P, Caulfield MC, Poulter NR ( 2001 ) . Cardiovascular risk factors in a cohort of 30 000 high-risk men and women in the UK: Cross-sectional, retrospective and prospective studies of screenees for the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) . Journal of Human Hypertension vol. 15 , ( SUPPL. 1 )

Metherell LA, Akker SA, Munroe PB, Rose SJ, Caulfield M, Savage MO, Chew SL, Clark AJ ( 2001 ) . Pseudoexon activation as a novel mechanism for disease resulting in atypical growth-hormone insensitivity . Am J Hum Genet vol. 69 , ( 3 ) 641 - 646 .

O'Brien E, McInnes GT, Stanton A, Thom S, Caulfield M, Atkins N, Nichol FM ( 2001 ) . Ambulatory blood pressure monitoring and 24-h blood pressure control as predictors of outcome in treated hypertensive patients . J HUM HYPERTENS vol. 15 , S47 - S51 .

Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE et al. ( 2001 ) . Anglo-Scandinavian Cardiac Outcomes Trial: a brief history, rationale and outline protocol . J HUM HYPERTENS vol. 15 , S11 - S12 .

Collier DJ, Bernardi L, Angell-James JE, Caulfield MJ, Sleight P, Anglo-Scandinavian Cardiac Outcomes Trial ( 2001 ) . Baroreflex sensitivity and heart rate variability as predictors of cardiovascular outcome in hypertensive patients with multiple risk factors for coronary disease . J Hum Hypertens vol. 15 Suppl 1 , S57 - S60 .

Chapman JN, Kirby P, Caulfield MC, Poulter NR ( 2001 ) . Cardiovascular risk factors in a cohort of 30,000 high-risk men and women in the UK: cross-sectional, retrospective and prospective studies of screenees for the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) . J HUM HYPERTENS vol. 15 , S23 - S26 .

Kirby PL, Caulfield MC, Collier DJ, Eldridge S, Griffiths CG, Hemingway H, Poulter NR, Feder GS et al. ( 2001 ) . Differential response to amlodipine and atenolol mono-therapy for hypertension by ethnic group . J Hum Hypertens vol. 15 Suppl 1 , S61 - S64 .

Poulter NR, Caulfield M, Feder G ( 2001 ) . Ethnic variations in response to a statin (EVIREST) . J HUM HYPERTENS vol. 15 , S87 - S89 .

Wilson S, Collier D, Johnston A, Poulter N, Feder G, Robson J, Caulfield M, Anglo-Scandinavian Cardiac Outcomes Trial ( 2001 ) . Evaluation of cardiovascular risk equations using the ASCOT cohort . J Hum Hypertens vol. 15 Suppl 1 , S31 - S33 .

White PC, Agarwal AK, Li AR, Nikkila H, Pratt JH, Caulfield M, Clark A, McTernan C et al. ( 2001 ) . Possible association but no linkage of the HSD11B2 gene encoding the kidney isozyme of 11 beta-hydroxysteroid dehydrogenase to hypertension in Black people . CLIN ENDOCRINOL vol. 55 , ( 2 ) 249 - 252 .

Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE et al. ( 2001 ) . Rationale, design, methods and baseline demography of participants of the Anglo-Scandinavian cardiac outcomes trial . J HYPERTENS vol. 19 , ( 6 ) 1139 - 1147 .

Sever PS, Dahlöf B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE et al. ( 2001 ) . Anglo-Scandinavian cardiac outcomes trial: A brief history, rationale and outline protocol . Journal of Human Hypertension vol. 15 , ( SUPPL. 1 )

Caulfield MJ ( 2001 ) . Genes for common diseases . BRIT J CLIN PHARMACO vol. 51 , ( 1 ) 1 - 3 .

Knight J, Gardner G, Clark A, Caulfield M ( 2000 ) . Investigation of chromosome 17q as a locus for human essential hypertension in African Caribbeans . Journal of Human Hypertension . vol. 14 , 385 - 387 .

Munroe PB, Caulfield MJ ( 2000 ) . Genetics of hypertension . Current Opinion in Genetics & Development vol. 10 , ( 3 ) 325 - 329 .

Munroe PB, Knight J, Caulfield MJ ( 2000 ) . 1990-2000: progress in determining high blood pressure genes . Annals, Academy of Medicine, Singapore vol. 29 , ( 3 ) 357 - 363 .

Caulfield M, Papp J, Pembroke J, Munroe P, Farrall M, Dominiczak A, Clayton D, Ratcliffe P et al. ( 2000 ) . A new tool for checks of data precision within the MRC British genetics of hypertension study . J HYPERTENS . vol. 18 , S180 - S180 .

Munroe P, Sandhu M, Jadhav D, Knight J, Clark A, Caulfield M ( 2000 ) . No association of the epithelial sodium channel beta-subunit T594M variant with essential hypertension in an African Caribbean population . J HYPERTENS vol. 18 , S178 - S178 .

Munroe PB, Strautnieks SS, Farrall M, Daniel HI, Lawson M, DeFreitas P, Fogarty P, Gardiner RM et al. ( 1998 ) . Absence of Linkage of the Epithelial Sodium Channel to Hypertension in Black Caribbeans* . American Journal of Hypertension vol. 11 , ( 8 ) 942 - 945 .

Caulfield M, Cafferkey M ( 1998 ) . Gene therapy: The possibilities and the problems . International Journal of Pharmaceutical Medicine vol. 12 , ( 1 ) 5 - 7 .

Brand E, Chatelain N, Keavney B, Caulfield M, Citterio L, Connell J, Grobbee D, Schmidt S et al. ( 1998 ) . Evaluation of the Angiotensinogen Locus in Human Essential Hypertension . Hypertension vol. 31 , ( 3 ) 725 - 729 .

Brand E, Chatelain N, de Bruijn T, Caulfield M, Connell J, Keavney B, Schunkert H, Schuster H et al. ( 1997 ) . 1.P.377 Evaluation of the angiotensinogen locus in human essential hypertension: An European study . Atherosclerosis vol. 134 , ( 1-2 )

Kotanko P, Binder A, Tasker J, DeFreitas P, Kamdar S, Clark AJL, Skrabal F, Caulfield M ( 1997 ) . Essential hypertension in African Caribbeans associates with a variant of the beta2-adrenoceptor . Hypertension vol. 30 , ( 4 ) 773 - 776 .

Munroe PB, Strautnieks SS, Farrall M, Daniel HI, Kamdar S, Lawson M, DeFreitas P, Fogarty P et al. ( 1997 ) . Investigation of the epithelial sodium channel (hENaC) as a candidate gene for essential hypertension (EH) in African Caribbeans . American Journal of Hypertension vol. 10 , ( S2 ) 5a - 5a .

Daniel H, Munroe P, Kamdar S, Lawson M, Lavender P, Forgaty P, Caulfield M ( 1997 ) . The atrial natriuretic peptide gene and essential hypertension in African-Caribbeans from St Vincent and the Grenadines . Journal of Human Hypertension vol. 11 , ( 2 ) 113 - 117 .

Caulfield M, Lavender P, Newell-Price J, Kamdar S, Farrall M, Clark AJL ( 1996 ) . Angiotensinogen in human essential hypertension . Hypertension . vol. 28 , 1123 - 1125 .

Caulfield M, Newell-Price J ( 1995 ) . The angiotensin converting enzyme gene in cardiovascular disease . Heart vol. 74 , ( 3 )

Munroe PB, Daniel HI, Farrall M, Lawson M, Bouloux PM, Caulfield MJ ( 1995 ) . Absence of genetic linkage between polymorphisms of the insulin receptor gene and essential hypertension . Journal of Human Hypertension . vol. 9 , 669 - 670 .

Caulfield M, Lavender P, Newell-Price J, Farrall M, Kamdar S, Daniel H, Lawson M, De Freitas P et al. ( 1995 ) . Linkage of the angiotensinogen gene locus to human essential hypertension in African Caribbeans . Journal of Clinical Investigation vol. 96 , ( 2 ) 687 - 692 .

Mattu R, Needham E, Galton D, Frangos E, Elwood P, Clark A, Caulfield M ( 1995 ) . The Ace I/D Polymorphism Identifies Cad in Low Risk Welsh Subjects . Clinical Science vol. 88 , ( s32 ) 1p - 1p .

Mattu RK, Needham EWA, Galton DJ, Frangos E, Clark AJL, Caulfield M ( 1995 ) . A DNA variant at the angiotensin-converting enzyme gene locus associates with coronary artery disease in the Caerphilly Heart Study . Circulation vol. 91 , ( 2 ) 270 - 274 .

Caulfield M, Lavender P, Newell-Price J, Farrall M, Daniel H, Kamdar S, Lawson M, Fogarty P et al. ( 1994 ) . 2 Linkage of the angiotensinogen gene to human essential hypertension in African Caribbeans . Journal of Hypertension vol. 12 , ( 11 )

Brown MJ, Clayton D ( 1994 ) . Linkage of the Angiotensinogen Gene to Essential Hypertension . New England Journal of Medicine vol. 331 , ( 16 ) 1096 - 1097 .

Mattu RK, Needham EWA, Caulfield M, Frangos E, Elwood PC, Clark A, Galton DJ ( 1994 ) . Association of the ACE I/D polymorphism with CAD in a Welsh population . Atherosclerosis vol. 109 , ( 1-2 )

Kamdar S, Daniel H, Fogarty P, Lawson M, Munroe P, Caulfield M ( 1994 ) . ACE insertion/deletion (I/D) polymorphism in Vincentian African Caribbeans with essential hypertension . Journal of Human Hypertension . vol. 8 ,

Munroe PB, Johnston A, Duke VM, Daniel HI, Bouloux PM, Lawson M, Caulfield MJ ( 1994 ) . Investigation of lipoprotein lipase (LPL) as a candidate gene for dyslipidaemic hypertension . Journal of Human Hypertension . vol. 8 , 613 - 614 .

Daniel HI, Munroe PB, Lawson M, Fogarty P, Kamdar SM, Caulfield MJ ( 1994 ) . Investigation of the renin gene as a putative locus for essential hypertension (EH) in Vincentian African Caribbeans . Journal of Human Hypertension . vol. 8 , 609 - 610 .

Caulfield M, Lavender P, Farrall M, Munroe P, Lawson M, Turner P, Clark A ( 1994 ) . Linkage of the Angiotensinogen Gene to Essential Hypertension . New England Journal of Medicine vol. 330 , ( 23 ) 1629 - 1633 .

Munroe PB, Caulfield M, Daniel H, Lawson M, Bouloux PMG, Turner P ( 1993 ) . Analysis of the insulin receptor RsaI polymorphism in essential hypertension . British Journal of Clinical Pharmacology . vol. 35 ,

Raveendran R, Heybroek WM, Caulfield M, Abrams SM, Wrigley PF, Slevin M, Turner P ( 1992 ) . Protein binding of indomethacin, methotrexate and morphine in patients with cancer . Clinical pharmacology research vol. 12 , ( 3 ) 117 - 122 .

Saleh S, Caulfield M, Lledo P, Johnston A, Turner P ( 1990 ) . Debrisoquine-type genetic polymorphism differences in medifoxamine pharmacokinetics . European Journal of Pharmacology . vol. 183 ,

Caulfield MJ, Dilkes MG, Iles RK, Handel BT, Oliver RTD ( 1990 ) . Rapid diagnosis of testicular choriocarcinoma by urinary pregnancy tests . The Lancet vol. 335 , ( 8699 )

Heybroek WM, Caulfield M, Johnston A, Turner P ( 1990 ) . Automatic on-line extraction coupled with electrochemical detection as an improved method for the HPLC co-analysis of codeine and morphine in plasma and gastric juice . Journal of Pharmaceutical and Biomedical Analysis vol. 8 , ( 8-12 ) 1021 - 1027 .

CAULFIELD MJ, DILKES MG, ILES RK, HANDEL BT, OLIVER RTD ( 1990 ) . RAPID DIAGNOSIS OF TESTICULAR CHORIOCARCINOMA BY URINARY PREGNANCY TESTS . LANCET vol. 335 , ( 8699 ) 1229 - 1229 .

Bouloux P-MG, Caulfield M, Lawson M, Turner P, Galton DJ ( 1989 ) . A study of Xho 1 polymorphisms of the human proatrial natriuretic peptide gene in essential hypertension . Journal of Hypertension vol. 7 , ( 11 ) 919 - 920 .

Blandy JP, Jenkins BJ, Fowler CG, Caulfield M, Badenoch DF, England HR, Hope-Stone HF, Mair GM et al. ( 1988 ) . Radical radiotherapy and salvage cystectomy for T2/3 cancer of the bladder . Progress in Clinical and Biological Research vol. 260 , 447 - 451 .