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Research

Publications: Prof Claude Chelala

Barclay NL, Burn E, Delmestri A, Duarte-Salles T, Golozar A, Man WY, Tan EH, Tietzova I et al. ( 2024 ) . Trends in incidence, prevalence, and survival of breast cancer in the United Kingdom from 2000 to 2021 . Scientific Reports vol. 14 , ( 1 )
Ang A, Michaelides A, Chelala C, Ullah D, Kocher HM, Bank BPT ( 2024 ) . Prognostication for recurrence patterns after curative resection for pancreatic ductal adenocarcinoma . Annals of Hepato-Biliary-Pancreatic Surgery vol. 0 , ( 0 ) 248 - 261 .
Ahmad TA, Dayem Ullah AZ, Chelala C, Gopal DP, Eto F, Henkin R, Samuel M, Finer S et al. ( 2024 ) . Prevalence of multimorbidity in survivors of 28 cancer sites: an English nationwide cross-sectional study . American Journal of Cancer Research vol. 14 , ( 2 ) 880 - 896 .
Ahmad TA, Gopal DP, Chelala C, Dayem Ullah AZ, Taylor SJ ( 2023 ) . Multimorbidity in people living with and beyond cancer: a scoping review . American Journal of Cancer Research vol. 13 , ( 9 ) 4346 - 4365 .
Baleeiro RB, Liu P, Dunmall LSC, Di Gioia C, Nagano A, Cutmore L, Wang J, Chelala C et al. ( 2023 ) . Personalized neoantigen viro-immunotherapy platform for triple-negative breast cancer . Journal for ImmunoTherapy of Cancer vol. 11 , ( 8 )
Pires MAF, Chelala CMDSCF, Chelala CA ( 2023 ) . Desestruturação da produção de soja na fronteira amazônica: o caso do estado do Amapá . Revista de Gestão e Secretariado (Management and Administrative Professional Review) vol. 14 , ( 6 ) 9700 - 9716 .
Chelala C, Costello-Goldring E ( 2023 ) . Chairwomen: Diagnostic studies for pancreatic cancer . Pancreatology vol. 23 , ( 4 )
Phillips MM, Pavlyk I, Allen M, Ghazaly E, Cutts R, Carpentier J, Berry JS, Nattress C et al. ( 2023 ) . Correction: A role for macrophages under cytokine control in mediating resistance to ADI-PEG20 (pegargiminase) in ASS1-deficient mesothelioma . Pharmacological Reports vol. 75 , ( 3 ) 753 - 753 .
Chelala CMDSCF, Chelala CA ( 2023 ) . AGRONEGÓCIOS E MUDANÇAS CLIMÁTICAS: REFLEXÕES SOBRE OS CONFLITOS SOCIOAMBIENTAIS BRASILEIROS . Terceira Margem Amazônia vol. 8 , ( 19 ) 35 - 55 .
Latreille J, Thorn G, Jdid R, Gendronneau G, Tabara Y, Harada Y, Forestier S, Chelala C et al. ( 2023 ) . 541 Gene set enrichment analysis identifies biological networks associated with skin aging in a large Japanese population: Data from the Nagahama cohort . Journal of Investigative Dermatology vol. 143 , ( 5 )
Oscanoa J, Latreille J, Le Clerc S, Muther C, Thorn G, Gendronneau G, Matsuda F, Forestier S et al. ( 2023 ) . 902 Development of a web-based platform to facilitate research to uncover the skin ageing mechanism . Journal of Investigative Dermatology vol. 143 , ( 5 )
Phillips MM, Pavlyk I, Allen M, Ghazaly E, Cutts R, Carpentier J, Berry JS, Nattress C et al. ( 2023 ) . A role for macrophages under cytokine control in mediating resistance to ADI-PEG20 (pegargiminase) in ASS1-deficient mesothelioma . Pharmacological Reports vol. 75 , ( 3 ) 570 - 584 .
Abdollahyan M, Gadaleta E, Asif M, Oscanoa J, Barrow-McGee R, Jones S, Jones LJ, Chelala C ( 2023 ) . Dynamic Biobanking for Advancing Breast Cancer Research . Journal of Personalized Medicine vol. 13 , ( 2 )
Oscanoa J, Latreille J, Le Clerc S, Muther C, Thorn G, Gendronneau G, Matsuda F, Forestier S et al. ( 2023 ) . Development of a web-based platform to facilitate research to uncover the skin ageing mechanism . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 143 , S154 - S154 .
Latreille J, Thorn G, Jdid R, Gendronneau G, Tabara Y, Harada Y, Forestier S, Chelala C et al. ( 2023 ) . Gene set enrichment analysis identifies biological networks associated with skin aging in a large Japanese population: Data from the Nagahama cohort . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 143 , S93 - S93 .
Zardab M, Balarajah V, Banerjee A, Stasinos K, Saad A, Imrali A, Hughes C, Roberts R et al. ( 2022 ) . Differentiating Ductal Adenocarcinoma of the Pancreas from Benign Conditions Using Routine Health Records: A Prospective Case-Control Study . Cancers vol. 15 , ( 1 )
Wu H, Wang M, Wu J, Francis F, Chang Y-H, Shavick A, Dong H, Poon MTC et al. ( 2022 ) . A survey on clinical natural language processing in the United Kingdom from 2007 to 2022 . npj Digital Medicine vol. 5 , ( 1 )
Sivapalan L, Kocher HM, Ross-Adams H, Chelala C ( 2022 ) . The molecular landscape of pancreatic ductal adenocarcinoma . Pancreatology vol. 22 , ( 7 ) 925 - 936 .
Baleeiro RB, Bouwens CJ, Liu P, Di Gioia C, Dunmall LSC, Nagano A, Gangeswaran R, Chelala C et al. ( 2022 ) . MHC class II molecules on pancreatic cancer cells indicate a potential for neo-antigen-based immunotherapy . OncoImmunology vol. 11 , ( 1 )
Gadaleta E, Thorn GJ, Ross‐Adams H, Jones LJ, Chelala C ( 2022 ) . Field cancerization in breast cancer . The Journal of Pathology vol. 257 , ( 4 ) 561 - 574 .
Speirs V, Cox A, Chelala C, James JA, Adams RA, Jones JL ( 2022 ) . A biobank perspective on use of tissue samples donated by trial participants . The Lancet Oncology vol. 23 , ( 5 )
Dawoud MM, Jones DT, Chelala C, Abdou AG, Dreger SA, Asaad N, El-Wahed MA, Jones L ( 2022 ) . Expression Profile of Myoepithelial Cells in DCIS: Do They Change From Protective Angels to Wicked Witches? . Applied Immunohistochemistry & Molecular Morphology vol. 30 , ( 6 ) 397 - 409 .
Sivapalan L, Thorn GJ, Gadaleta E, Kocher HM, Ross-Adams H, Chelala C ( 2022 ) . Longitudinal profiling of circulating tumour DNA for tracking tumour dynamics in pancreatic cancer . BMC Cancer vol. 22 , ( 1 )
Dayem Ullah AZM, Stasinos K, Chelala C, Kocher HM ( 2021 ) . Temporality of clinical factors associated with pancreatic cancer: a case-control study using linked electronic health records . BMC Cancer vol. 21 , ( 1 )
Keane L, Antignano I, Riechers S-P, Zollinger R, Dumas AA, Offermann N, Bernis ME, Russ J et al. ( 2021 ) . mTOR-dependent translation amplifies microglia priming in aging mice . Journal of Clinical Investigation vol. 131 , ( 20 )
Lu S, Zhang Z, Du P, Chard LS, Yan W, El Khouri M, Wang Z, Zhang Z et al. ( 2021 ) . Correction: A Virus-infected, Reprogrammed Somatic Cell–derived Tumor Cell (VIReST) Vaccination Regime can Prevent Initiation and Progression of Pancreatic Cancer . Clinical Cancer Research vol. 27 , ( 9 ) 2663 - 2663 .
Allen N, Allen M, Gomm J, Nelan R, Nagano A, Chelala C, Jones L ( 2021 ) . P020. Defining molecular signatures to personalise management of patients with early breast cancer . European Journal of Surgical Oncology . vol. 47 ,
Ullah AZMD, Sivapalan L, Kocher HM, Chelala C ( 2021 ) . COVID-19 in patients with hepatobiliary and pancreatic diseases: a single-centre cross-sectional study in East London . BMJ Open vol. 11 , ( 4 )
Marzec J, Ross-Adams H, Pirrò S, Wang J, Zhu Y, Mao X, Gadaleta E, Ahmad AS et al. ( 2021 ) . The Transcriptomic Landscape of Prostate Cancer Development and Progression: An Integrative Analysis . Cancers vol. 13 , ( 2 )
Sivapalan L, Thorn G, Gadaleta E, Kocher H, Ross-Adams H, Chelala C ( 2021 ) . Longitudinal profiling of circulating tumour DNA for tracking tumour dynamics in pancreatic cancer .
Borakati A, Stasinos K, Ullah D, Chelala C, Kocher H ( 2021 ) . Effect of Diabetes Mellitus on Survival in Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-analysis . Hepato Pancreato Biliary vol. 23 , s682 - s683 .
Oscanoa J, Sivapalan L, Abdollahyan M, Gadaleta E, Chelala C ( 2021 ) . SNPnexus COVID: Facilitating the Analysis of COVID-19 Host Genetics . Archives of Clinical and Biomedical Research vol. 05 , ( 05 )
Sivapalan L, Kocher HM, Ross-Adams H, Chelala C ( 2020 ) . Molecular profiling of ctDNA in pancreatic cancer: Opportunities and challenges for clinical application . Pancreatology vol. 21 , ( 2 ) 363 - 378 .
Ullah AD, Kocher H, Chelala C ( 2020 ) . COVID-19 in patients with hepatobiliary and pancreatic diseases in East London: a single-centre cohort study . Pancreatology vol. 20 , ( 8 )
Ullah D, Kocher H, Chelala C ( 2020 ) . Data integration for patient benefit . Pancreatology vol. 20 , ( 8 )
Imrali A, Hughes CS, Coetzee AS, Delvecchio FR, Saad A, Roberts R, Chelala C, ChinAleong J et al. ( 2020 ) . Validation of a Novel, Flash‐Freezing Method: Aluminum Platform . Current Protocols Essential Laboratory Techniques vol. 21 , ( 1 )
Ullah AZMD, Sivapalan L, Kocher HM, Chelala C ( 2020 ) . COVID-19 in patients with hepatobiliary and pancreatic diseases: A single-centre cross-sectional study in East London .
Gadaleta E, Fourgoux P, Pirró S, Thorn GJ, Nelan R, Ironside A, Rajeeve V, Cutillas PR et al. ( 2020 ) . Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer . npj Breast Cancer vol. 6 , ( 1 )
Gadaleta E, Fourgoux P, Pirró S, Thorn GJ, Nelan R, Ironside A, Rajeeve V, Cutillas PR et al. ( 2020 ) . Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer . NPJ Breast Cancer vol. 6 , ( 1 )
Xu R, Jones W, Wilcz‐Villega E, Costa AS, Rajeeve V, Bentham RB, Bryson K, Nagano A et al. ( 2020 ) . The breast cancer oncogene IKKε coordinates mitochondrial function and serine metabolism . EMBO Reports vol. 21 , ( 9 )
Oscanoa J, Sivapalan L, Gadaleta E, Ullah AZD, Lemoine NR, Chelala C ( 2020 ) . SNPnexus: a web server for functional annotation of human genome sequence variation (2020 update) . Nucleic Acids Research vol. 48 , ( W1 ) w185 - w192 .
Montero Melendez T, Nagano A, Chelala C, Filer A, Buckley CD, Perretti M ( 2020 ) . Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis . Nature Communications vol. 11 , ( 1 ) Article 745 ,
Lu S, Zhang Z, Du P, Chard LS, Yan W, Khouri ME, Wang Z, Zhang Z et al. ( 2020 ) . A Virus-Infected, Reprogrammed Somatic Cell–Derived Tumor Cell (VIReST) Vaccination Regime Can Prevent Initiation and Progression of Pancreatic Cancer . Clinical Cancer Research vol. 26 , ( 2 ) 465 - 476 .
Pirrò S, Spada F, Gadaleta E, Ferrentino F, Thorn GJ, Cesareni G, Chelala C ( 2019 ) . HiPPO and PANDA: Two Bioinformatics Tools to Support Analysis of Mass Cytometry Data . J Comput Biol
Martin S ( 2019 ) . MLH1 deficiency leads to deregulated mitochondrial metabolism . Cell Death and Disease vol. 10 , 795 - 795 .
Reader CS, Vallath S, Steele CW, Haider S, Brentnall A, Desai A, Moore KM, Jamieson NB et al. ( 2019 ) . The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy . The Journal of Pathology vol. 249 , ( 3 ) 332 - 342 .
Pirrò S, Gadaleta E, Galgani A, Colizzi V, Chelala C ( 2019 ) . SMAC, a computational system to link literature, biomedical and expression data . Scientific Reports vol. 9 , ( 1 )
Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward J et al. ( 2019 ) . Correction: Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma . Leukemia vol. 33 , ( 6 ) 1540 - 1540 .
Barry S, Carlsen E, Marques P, Stiles CE, Gadaleta E, Berney DM, Roncaroli F, Chelala C et al. ( 2019 ) . Tumor microenvironment defines the invasive phenotype of AIP-mutation-positive pituitary tumors . Oncogene vol. 38 , ( 27 ) 5381 - 5395 .
Allen N, Allen M, Ahmed K, Gomm J, Nelan R, Nagano A, Chelala C, Gadaleta E et al. ( 2019 ) . Defining molecular signatures to personalise management of patients with early breast cancer . CANCER RESEARCH . Conference: 2018 San Antonio Breast Cancer Symposium from: 04/12/2019 to: 08/12/2019 , vol. 79 ,
Inman GJ, Wang J, Nagano A, Alexandrov LB, Purdie KJ, Taylor RG, Sherwood V, Thomson J et al. ( 2018 ) . The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature . Nature Communications vol. 9 , ( 1 )
Arnandis T, Monteiro P, Adams SD, Bridgeman VL, Rajeeve V, Gadaleta E, Marzec J, Chelala C et al. ( 2018 ) . Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion . Developmental Cell vol. 47 , ( 4 ) 409 - 424.e9 .
Foxler DE, Bridge KS, Foster JG, Grevitt P, Curry S, Shah KM, Davidson KM, Nagano A et al. ( 2018 ) . A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia . EMBO Mol Med
Bladen JC, Wang J, Sangaralingam A, Moosajee M, Fitchett C, Chelala C, Beaconsfield M, O’Toole EA et al. ( 2018 ) . MicroRNA and transcriptome analysis in periocular Sebaceous Gland Carcinoma . Scientific Reports vol. 8 , ( 1 )
Ullah AZD, Oscanoa J, Wang J, Nagano A, Lemoine NR, Chelala C ( 2018 ) . SNPnexus: assessing the functional relevance of genetic variation to facilitate the promise of precision medicine . Nucleic Acids Research vol. 46 , ( W1 ) w109 - w113 .
Fearon AE, Carter EP, Clayton NS, Wilkes EH, Baker A-M, Kapitonova E, Bakhouche BA, Tanner Y et al. ( 2018 ) . PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer . Cell Reports vol. 22 , ( 9 ) 2469 - 2481 .
Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward J et al. ( 2018 ) . Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma . Leukemia vol. 32 , ( 5 ) 1261 - 1265 .
WANG Y, Dayem Ullah AZ, Chelala C ( 2018 ) . IW-Scoring: an Integrative Weighted Scoring framework for annotating and prioritising genetic variations in the noncoding genome. Nucleic Acids Research . Nucleic Acids Research vol. 46 , ( 8 ) e47 - e47 .
Wang J, Ullah AZD, Chelala C ( 2018 ) . IW-Scoring: an Integrative Weighted Scoring framework for annotating and prioritizing genetic variations in the noncoding genome . Nucleic Acids Research vol. 46 , ( 8 ) e47 - e47 .
Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D et al. ( 2017 ) . Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers . Cancer Discov
Barry S, Solomou A, Vignola L, Collier D, Carlsen E, Gadaleta E, Berney DM, Chelala C et al. ( 2017 ) . A comprehensive analysis of the AIP mutation positive pituitary tumour microenvironment: role of stromal cells and the pro-inflammatory cytokine network . Endocrine Abstracts
Marzec J, Dayem Ullah AZ, Pirrò S, Gadaleta E, Crnogorac-Jurcevic T, Lemoine NR, Kocher HM, Chelala C ( 2017 ) . The Pancreatic Expression Database: 2018 update . Nucleic Acids Res vol. 46 , ( D1 ) D1107 - D1110 .
Gadaleta E, Pirrò S, Ullah AZD, Marzec J, Chelala C ( 2017 ) . BCNTB bioinformatics: the next evolutionary step in the bioinformatics of breast cancer tissue banking . Nucleic Acids Research vol. 46 , ( Database issue )
Sangaralingam A, Dayem Ullah AZ, Marzec J, Gadaleta E, Nagano A, Ross-Adams H, Wang J, Lemoine NR et al. ( 2017 ) . 'Multi-omic' data analysis using O-miner . Brief Bioinform
Chupin J, Nagano A, Haley V, Lenihan C, Cavicchioli F, O’Leary K, Sahgal N, Nigro CL et al. ( 2017 ) . Abstract 104: miRNAs in the 14q32 cluster are involved in lapatinib resistance . Cancer Research . vol. 77 , 104 - 104 .
Wang J, Dumartin L, Mafficini A, Ulug P, Sangaralingam A, Alamiry NA, Radon TP, Salvia R et al. ( 2017 ) . Splice variants as novel targets in pancreatic ductal adenocarcinoma . Scientific Reports vol. 7 , ( 1 )
Tawana K, Wang J, Király PA, Kállay K, Benyó G, Zombori M, Csomor J, Al Seraihi A et al. ( 2017 ) . Recurrent somatic JAK-STAT pathway variants within a RUNX1-mutated pedigree . European Journal of Human Genetics vol. 25 , ( 8 ) 1020 - 1024 .
Ironside A, Hawkesford K, Gomm J, Haywood L, Goulding I, Wang J, Lamaziere A, Poirot M et al. ( 2017 ) . Molecular mediators of mammographic density . CANCER RESEARCH . Conference: 2016 San Antonio Breast Cancer Symposium from: 06/12/2016 to: 10/12/2016 , vol. 77 ,
Morrissey B, Blyth K, Carter P, Chelala C, Jones L, Holen I, Speirs V ( 2017 ) . The Sharing Experimental Animal Resources, Coordinating Holdings (SEARCH) Framework: Encouraging Reduction, Replacement, and Refinement in Animal Research . PLoS Biol vol. 15 , ( 1 ) e2000719 - e2000719 .
Moniz LS, Surinova S, Ghazaly E, Velasco LG, Haider S, Rodríguez-Prados JC, Berenjeno IM, Chelala C et al. ( 2017 ) . Phosphoproteomic comparison of Pik3ca and Pten signalling identifies the nucleotidase NT5C as a novel AKT substrate . Scientific Reports vol. 7 , ( 1 )
Besley C, Kotsiou E, Petty R, Sangaralingam A, Chelala C, Ghazaly E, LeDieu R, Gribben J et al. ( 2017 ) . ALLORESPONSES OF HUMAN T-CELLS FROM ADULT PERIPHERAL BLOOD AND UMBILICAL CORD BLOOD ARE DIFFERENTIALLY IMPACTED BY LENALIDOMIDE - IMPLICATIONS FOR AHSCT . HAEMATOLOGICA . vol. 102 , 638 - 638 .
Harwood C, Proby C, Wang J, Nagano A, Alexandrov L, Purdie K, Chelala C, Inman G et al. ( 2017 ) . Chronic azathioprine treatment is causal in cutaneous squamous cell carcinoma development and is associated with a novel mutational signature . BRITISH JOURNAL OF DERMATOLOGY . vol. 177 , 9 - 10 .
Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward JA et al. ( 2017 ) . Genomic Profiling Reveals Spatial Intra-Tumor Heterogeneity in Follicular Lymphoma . BLOOD . vol. 130 ,
Thomson J, Wang A, Nagano A, Chelala C, Purdie K, Har C, Proby C, Inman G et al. ( 2017 ) . Understanding actinic keratosis and squamous cell carcinoma in the era of whole-exome and -genome sequencing . BRITISH JOURNAL OF DERMATOLOGY . vol. 177 , 15 - 16 .
Besley C, Kotsiou E, Petty R, Ajanthah S, Chelala C, Ghazaly E, Le Dieu R, Davies J et al. ( 2016 ) . Alloresponses of Human T-Cells from Adult Peripheral Blood and Umbilical Cord Blood Are Differentially Impacted By Lenalidomide . Blood . vol. 128 ,
Makoukji J, Makhoul NJ, Khalil M, El-Sitt S, Aldin ES, Jabbour M, Boulos F, Gadaleta E et al. ( 2016 ) . Gene expression profiling of breast cancer in Lebanese women . Scientific Reports vol. 6 , 36639 - 36639 .
Ghayad SE, Rammal G, Ghamloush F, Basma H, Nasr R, Diab-Assaf M, Chelala C, Saab R ( 2016 ) . Exosomes derived from embryonal and alveolar rhabdomyosarcoma carry differential miRNA cargo and promote invasion of recipient fibroblasts . Scientific Reports vol. 6 , Article 37088 ,
Parker H, Rose-Zerilli MJJ, Larrayoz M, Clifford R, Edelmann J, Blakemore S, Gibson J, Wang J et al. ( 2016 ) . Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia . LEUKEMIA vol. 30 , ( 11 ) 2179 - 2186 .
Shaid M, Barry S, Gadaleta E, Chelala C, Korbonits M ( 2016 ) . The clinical, pathological and molecular differences between sparsely and densely granulated somatotroph adenomas . Endocrine Abstracts
Barry S, Carlsen E, Gadaleta E, Berney D, Chelala C, Crnogorac-Jurcevic T, Korbonits M ( 2016 ) . The role of the microenvironment in the invasive phenotype of familial pituitary tumours . Endocrine Abstracts
Speirs V, Morrisey B, Holen I, Blyth K, Carter P, Chelala C, Jones L ( 2016 ) . SEARCHBreast: An online resource designed to increase the efficiency of using materials derived from breast cancer studies in animals . Journal of Pathology vol. 240 , ( 1 ) 120 - 120 .
Mao X, Luo F, Boyd LK, Zhou B, Zhang Y, Stankiewicz E, Marzec J, Vasiljevic N et al. ( 2016 ) . NKAIN2 functions as a novel tumor suppressor in prostate cancer . Oncotarget
Cammareri P, Rose AM, Vincent DF, Wang J, Nagano A, Libertini S, Ridgway RA, Athineos D et al. ( 2016 ) . Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma . Nature Communications vol. 7 , 12493 - 12493 .
Jones JL, Gomm J, Haywood L, Morgan A, Goulding I, Allen M, Chelala C, Gadelata E ( 2016 ) . Breast Cancer Now Cell Culture Programme: a bespoke resource for the research community . Breast Cancer Research and Treatment . Conference: UK Breast Cancer Research Symposium 2016 from: 22/07/2016 to: 23/07/2016 , vol. 159 , 196 - 196 .
Balarajah V, Ambily A, Dayem Ullah AZ, Imrali A, Dowe T, Al-Sarireh B, Abu Hilal M, Davidson BR et al. ( 2016 ) . Pancreatic cancer tissue banks: where are we heading? . Future Oncol vol. 12 , ( 23 ) 2661 - 2663 .
Locke M, Ghazaly E, Freitas MO, Mitsinga M, Lattanzio L, Lo Nigro C, Nagano A, Wang J et al. ( 2016 ) . Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1 . Cell Reports vol. 16 , ( 6 ) 1604 - 1613 .
Carter P, Blyth K, Holen I, Jones L, Morrissey B, Speirs V, Chelala C ( 2016 ) . The SEARCHBreast Portal: A Virtual Bioresource to Facilitate the Sharing of Surplus Animal Materials Derived from Breast Cancer Studies . Open Journal of Bioresources vol. 3 ,
Morrissey B, Blyth K, Carter P, Chelala C, Jones L, Holen I, Speirs V ( 2016 ) . 859 SEARCHBreast; making surplus material from in vivo models of breast cancer available for research . European Journal of Cancer vol. 61 ,
Morrissey B, Holen I, Chelala C, Carter P, Jones L, Blyth K, Speirs V ( 2016 ) . Introducing SEARCHBreast: a virtual resource to facilitate sharing of surplus animal material developed for breast cancer research . NPJ Breast Cancer vol. 2 , 16020 - 16020 .
Parker H, Rose-Zerilli MJJ, Larrayoz M, Clifford R, Edelmann J, Blakemore S, Gibson J, Wang J et al. ( 2016 ) . Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia . Leukemia
GROSE RP, Dawkins JBN, Wang J, maniati, heward, koniali, kocher, martin et al. ( 2016 ) . Reduced expression of histone methyltransferases KMT2C and KMT2D correlates with improved outcome in pancreatic ductal adenocarcinoma . Cancer Research
Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Al Seraihi AF et al. ( 2016 ) . Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma (vol 48, pg 183, 2016) . NATURE GENETICS vol. 48 , ( 6 ) 700 - 700 .
Morrissey B, Blyth K, Carter P, Chelala C, Jones L, Holen I, Speirs V ( 2016 ) . SEARCHBreast: A new online resource to make surplus material from in vivo models of breast cancer visible and accessible to researchers . Breast Cancer Research vol. 18 , ( 1 )
Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Seraihi AFA et al. ( 2016 ) . Corrigendum: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma . Nat Genet vol. 48 , ( 6 ) 700 - 700 .
Blyth K, Carter P, Morrissey B, Chelala C, Jones L, Holen I, Speirs V ( 2016 ) . SEARCHBreast: a new resource to locate and share surplus archival material from breast cancer animal models to help address the 3Rs . Breast Cancer Research and Treatment vol. 156 , ( 3 ) 447 - 452 .
Marzec J, Mao X, Li M, Wang M, Feng N, Gou X, Wang G, Sun Z et al. ( 2016 ) . A genetic study and meta-analysis of the genetic predisposition of prostate cancer in a Chinese population . Oncotarget vol. 7 , ( 16 ) 21393 - 21403 .
Rose-Zerilli MJJ, Gibson J, Wang J, Tapper W, Davis Z, Parker H, Larrayoz M, McCarthy H et al. ( 2016 ) . Longitudinal copy number, whole exome and targeted deep sequencing of 'good risk' IGHV-mutated CLL patients with progressive disease . Leukemia vol. 30 , ( 6 ) 1301 - 1310 .
Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Al Seraihi AF et al. ( 2016 ) . Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma . Nature Genetics vol. 48 , ( 2 ) 183 - 188 .
Proby C, Inman G, Wang J, Nagano A, Purdie K, Mladkova N, Lambert S, Gulati A et al. ( 2016 ) . Characterisation of the molecular landscape of cutaneous squamous cell carcinoma . MELANOMA RESEARCH . vol. 26 , E69 - E69 .
Proby CM, Inman G, Wang JA, Nagano A, Purdie KJ, Gulati A, Lambert S, Mladkova N et al. ( 2016 ) . Characterisation of the molecular landscape of cutaneous squamous cell carcinoma and Identification of a novel mutational signature associated with chronic azathioprine exposure . BRITISH JOURNAL OF DERMATOLOGY . vol. 175 , 58 - 59 .
Cammareri P, Rose A, Vincent D, Wang J, Nagano A, Libertini S, Ridgway R, Mchugh A et al. ( 2016 ) . Frequent loss of function mutations in TGFβR1 and TGFβR2 implicate hair follicle bulge stem cells as a cell of origin of cutaneous squamous cell carcinoma . MELANOMA RESEARCH . vol. 26 , E63 - E64 .
Araf S, Wang J, Pangault C, Kotsiou E, Hoxha E, Iqbal S, Davies J, Johnson P et al. ( 2016 ) . GENOMIC PROFILING REVEALS SPATIAL HETEROGENEITY IN FOLLICULAR LYMPHOMA: IMPLICATIONS FOR PRECISION MEDICINE . HAEMATOLOGICA . vol. 101 , 270 - 270 .
Inman G, Proby CM, Wang JA, Nagano A, Alexandrov L, Purdie K, Rose A, Weir L et al. ( 2016 ) . Identification of a novel mutational signature in cutaneous SCC associated with chronic azathioprine exposure . MELANOMA RESEARCH . vol. 26 , E114 - E115 .
Cammareri P, Rose A, Vincent D, Wang J, Nagano A, Coates P, Sapkota G, Purdie K et al. ( 2016 ) . Inactivation of transforming growth factor-β receptors in human cutaneous squamous cell carcinoma and murine hair follicle stem cells drives tumorigenesis . BRITISH JOURNAL OF DERMATOLOGY . vol. 174 , E51 - E52 .
Morrissey B, Blyth K, Carter P, Chelala C, Jones L, Holen I, Speirs V ( 2016 ) . SEARCHBreast; making surplus material from in vivo models of breast cancer available for research . EUROPEAN JOURNAL OF CANCER . vol. 61 , S198 - S198 .
Proby C, Inman G, Nagano A, Purdie K, Mladkova N, Alexandrov L, Stratton M, Watt S et al. ( 2016 ) . The molecular landscape of cutaneous squamous cell carcinoma . BRITISH JOURNAL OF DERMATOLOGY . vol. 174 , E50 - E51 .
Rio-Machin A, Cardoso S, Tawana K, Wang J, Chelala C, Plagnol V, Wallis Y, Ryan G et al. ( 2016 ) . WHOLE EXOME SEQUENCING REVEALS NOVEL CANDIDATE GENES IN FAMILIAL MDS/AML . HAEMATOLOGICA . vol. 101 , 205 - 206 .
Rose-Zerilli MJJ, Parker H, Larrayoz M, Clifford R, Blakemore S, Edelmann J, Gibson J, Wang J et al. ( 2015 ) . Genomic Disruption of the Histone Methyltransferase SETD2 in Chronic Lymphocytic Leukemia . Blood vol. 126 , ( 23 )
Morrissey B, Blyth K, Carter P, Chelala C, Holen I, Jones L, Speirs V ( 2015 ) . SEARCHBreast Workshop Proceedings: 3D Modelling of Breast Cancer . Alternatives to Laboratory Animals vol. 43 , ( 6 ) 367 - 375 .
Debernardi S, Massat NJ, Radon TP, Sangaralingam A, Banissi A, Ennis DP, Dowe T, Chelala C et al. ( 2015 ) . Noninvasive urinary miRNA biomarkers for early detection of pancreatic adenocarcinoma . American Journal of Cancer Research vol. 5 , ( 11 ) 3455 - 3466 .
Makoukji J, Raad M, Genadry K, El-Sitt S, Makhoul NJ, Aldin ES, Nohra E, Jabbour M et al. ( 2015 ) . Association between CLN3 (Neuronal Ceroid Lipofuscinosis, CLN3 Type) Gene Expression and Clinical Characteristics of Breast Cancer Patients . Frontiers in Oncology vol. 5 ,
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Speirs V, Chelala C, Coates R, Jones JL, Matharoo-Ball B, Quinlan P ( 2014 ) . The Breast Cancer Campaign Tissue Bank: Generating new biomaterials to accelerate breast cancer research . EUROPEAN JOURNAL OF CANCER . vol. 50 , S200 - S200 .
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Moore K, Thomas G, Duffy S, Warwick J, Gabe R, Chou P, Ellis I, Green A et al. ( 2013 ) . Abstract P4-15-01: Integrin avb6 is a therapeutic target for high-risk breast cancer and enhances trastuzumab efficacy . Cancer Research vol. 73 , ( 24_Supplement )
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Tawana K, Renneville A, Wang J, Georgiades P, Thomas X, Mialou V, Savic A, Van Delft FW et al. ( 2013 ) . Familial AML With Germline CEBPA Mutations: Extended Clinical Outcomes and Analysis Of Secondary Mutations Using Whole Exome Sequencing . Blood . vol. 122 ,
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Ene-Obong A, Clear AJ, Watt J, Wang J, Fatah R, Riches JC, Marshall JF, Chin-Aleong J et al. ( 2013 ) . Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma . Gastroenterology vol. 145 , ( 5 ) 1121 - 1132 .
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Okosun J, Bödör C, Wang J, Araf S, Chelala C, Fitzgibbon J ( 2013 ) . Genomic analysis reveals epigenetic ‘addiction’ underpinning follicular lymphoma and its transformation – a rationale for targeted epigenetic therapies . Clinical Epigenetics vol. 5 , ( Suppl 1 )
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Barry S, Gadaleta E, Chelala C, Korbonits M ( 2013 ) . Gene expression profiling of familial and sporadic pituitary adenomas . Endocrine Abstracts
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Froeling FEM, Feig C, Chelala C, Dobson R, Mein CE, Tuveson DA, Clevers H, Hart IR et al. ( 2011 ) . Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progression . Gastroenterology vol. 141 , ( 4 ) 1486 - 1497.14 .
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Allen MD, Vaziri R, Green M, Chelala C, Brentnall AR, Dreger S, Vallath S, Nitch-Smith H et al. ( 2011 ) . Clinical and functional significance of α9β1 integrin expression in breast cancer: a novel cell-surface marker of the basal phenotype that promotes tumour cell invasion . J Pathol vol. 223 , ( 5 ) 646 - 658 .
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Flak MB, Connell CM, Chelala C, Archibald K, Salako MA, Pirlo KJ, Lockley M, Wheatley SP et al. ( 2010 ) . p21 Promotes oncolytic adenoviral activity in ovarian cancer and is a potential biomarker . Mol Cancer vol. 9 ,
Delage B, Chelala C, Chacko A, Jithesh PV, Fennell DA, Lemoine NR, Szlosarek PW ( 2010 ) . Abstract 4445: Pegylated arginine deiminase induces mitochondrial apoptosis and synergizes with cisplatin in ASS1-negative malignant pleural mesothelioma . Cancer Research . vol. 70 , 4445 - 4445 .
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Eccles DM, An Q, Jones L, Tapper W, Chelala C, Iravani M, Mckay A, Hammond V et al. ( 2009 ) . A Novel Tumour-Based Test To Identify Breast Cancer Due to BRCA1 and BRCA2 Mutations . CANCER RESEARCH . vol. 69 , 775S - 775S .
Dawoud MM, Jones D, Hodivala-Dilke K, Dreger S, Chelala C, Asaad NY, Jones L ( 2009 ) . Microenvironmental Changes in DCIS: Myoepithelial Cells Change from Tumour Suppressor to Tumour Promoter . CANCER RESEARCH . vol. 69 , 760S - 760S .
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Yeoh C, Chelala C ( 2009 ) . Molecular analysis of tamoxifen-resistant pathways in breast cancer cell-lines and breast cancer tissues . Journal of Clinical Oncology vol. 27 , ( 15_suppl ) e22094 - e22094 .
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