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Publications:  Dr Adrian Biddle

Jolly MK, Somarelli JA, Sheth M, Biddle A, Tripathi SC, Armstrong AJ, Hanash SM, Bapat SA et al.(2019). Hybrid epithelial/mesenchymal phenotypes promote metastasis and therapy resistance across carcinomas. Pharmacol Ther vol. 194, 161-184.
10.1016/j.pharmthera.2018.09.007
MACKENZIE IC, Rodrigues MF, Gammon L, RAHMAN M, BIDDLE A, Nunes FD(2018). Effects of Cetuximab and Erlotinib on the behaviour of cancer stem cells in head and neck squamous cell carcinoma. Oncotarget
10.18632/oncotarget.24416
O'Brien-Ball C, Biddle A(2017). Reprogramming to developmental plasticity in cancer stem cells. Dev Biol vol. 430, (2) 266-274.
10.1016/j.ydbio.2017.07.025
Vig NK, Gammon L, Peyric E, Rahman M, Biddle A, Mackenzie IC (2017). The amoeboid cell in cancer. BRITISH JOURNAL OF SURGERY. vol. 104, 43-43.
BIDDLE A, Gammon L, Liang X, Costea DE, Mackenzie IC(2016). Phenotypic Plasticity Determines Cancer Stem Cell Therapeutic Resistance in Oral Squamous Cell Carcinoma. EBioMedicine
10.1016/j.ebiom.2016.01.007
Gemenetzidis E, Gammon L, Biddle A, Emich H, Mackenzie IC(2015). Invasive oral cancer stem cells display resistance to ionising radiation. Oncotarget vol. 6, (41) 43964-43977.
10.18632/oncotarget.6268
Vig N, Mackenzie IC, Biddle A(2015). Phenotypic plasticity and epithelial-to-mesenchymal transition in the behaviour and therapeutic response of oral squamous cell carcinoma. J Oral Pathol Med vol. 44, (9) 649-655.
10.1111/jop.12306
Shigeishi H, Biddle A, Gammon L, Rodini CO, Yamasaki M, Seino S, Sugiyama M, Takechi M et al.(2015). Elevation in 5-FU-induced apoptosis in head and neck cancer stem cells by a combination of CDHP and GSK3β inhibitors. J Oral Pathol Med vol. 44, (3) 201-207.
10.1111/jop.12230
Hufbauer M, Biddle A, Borgogna C, Gariglio M, Doorbar J, Storey A, Pfister H, Mackenzie I et al.(2013). Expression of Betapapillomavirus Oncogenes Increases the Number of Keratinocytes with Stem Cell-Like Properties. JOURNAL OF VIROLOGY vol. 87, (22) 12158-12165.
10.1128/JVI.01510-13
Shigeishi H, Biddle A, Gammon L, Emich H, Rodini CO, Gemenetzidis E, Fazil B, Sugiyama M et al.(2013). Maintenance of stem cell self-renewal in head and neck cancers requires actions of GSK3β influenced by CD44 and RHAMM. Stem Cells vol. 31, (10) 2073-2083.
10.1002/stem.1418
Biddle A, Gammon L, Fazil B, Mackenzie IC(2013). CD44 staining of cancer stem-like cells is influenced by down-regulation of CD44 variant isoforms and up-regulation of the standard CD44 isoform in the population of cells that have undergone epithelial-to-mesenchymal transition. PLoS One vol. 8, (2)
10.1371/journal.pone.0057314
Gammon L, Biddle A, Heywood HK, Johannessen AC, Mackenzie IC(2013). Sub-sets of cancer stem cells differ intrinsically in their patterns of oxygen metabolism. PLoS One vol. 8, (4)
10.1371/journal.pone.0062493
Biddle A, Mackenzie IC(2012). Cancer stem cells and EMT in carcinoma. Cancer Metastasis Rev
10.1007/s10555-012-9345-0
VALORANI MG, Montelatici E, Germani A, Biddle A, D'Alessandro D, Strollo R, Patrizi MP, Lazzari L et al.(2012). Pre-culturing human adipose tissue mesenchymal stem cells under hypoxia increases their adipogenic and osteogenic differentiation potential. Cell Proliferation vol. 45, (3) 225-238.
10.1111/j.1365-2184.2012.00817
Biddle A, Liang X, Gammon L, Fazil B, Harper LJ, Emich H, Costea DE, Mackenzie IC(2011). Cancer stem cells in squamous cell carcinoma switch between two distinct phenotypes that are preferentially migratory or proliferative. Cancer Res vol. 71, (15) 5317-5326.
10.1158/0008-5472.CAN-11-1059
Gammon L, Biddle A, Fazil B, Harper L, Mackenzie IC(2011). Stem cell characteristics of cell sub-populations in cell lines derived from head and neck cancers of Fanconi anemia patients. J Oral Pathol Med vol. 40, (2) 143-152.
10.1111/j.1600-0714.2010.00972.x
Valorani MG, Germani A, Otto WR, Harper L, Biddle A, Khoo CP, Lin WR, Hawa MI et al.(2010). Hypoxia increases Sca-1/CD44 co-expression in murine mesenchymal stem cells and enhances their adipogenic differentiation potential. Cell Tissue Res vol. 341, (1) 111-120.
10.1007/s00441-010-0982-8
Harper LJ, Costea DE, Gammon L, Fazil B, Biddle A, Mackenzie IC(2010). Normal and malignant epithelial cells with stem-like properties have an extended G2 cell cycle phase that is associated with apoptotic resistance. BMC Cancer vol. 10,
10.1186/1471-2407-10-166
Biddle A, Simeoni I, Gurdon JB(2009). Xenopus oocytes reactivate muscle gene transcription in transplanted somatic nuclei independently of myogenic factors. DEVELOPMENT vol. 136, (16) 2695-2703.
10.1242/dev.036327
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