Publications: Prof Michele Bombardieri

Ruscitti P, Allanore Y, Baldini C, Barilaro G, Bartoloni Bocci E, Bearzi P, Bellis E, Berardicurti O et al. ( 2024 ) . Tailoring the treatment of inflammatory rheumatic diseases by a better stratification and characterization of the clinical patient heterogeneity. Findings from a systematic literature review and experts' consensus . Autoimmunity Reviews vol. 23 , ( 7-8 )

Jagemann L, Sciucca N, Bombardieri M, Corsiero E ( 2024 ) . Efficient generation of a stable CHO-K1 cell line overexpressing the human water channel aquaporin-5 as tool to generate therapeutic antibodies . Scientific Reports vol. 14 , ( 1 )

Mauro D, Lin X, Pontarini E, Wehr P, Guggino G, Tang Y, Deng C, Gandolfo S et al. ( 2024 ) . CD8+ tissue-resident memory T cells are expanded in primary Sjögren’s disease and can be therapeutically targeted by CD103 blockade . Annals of the Rheumatic Diseases vol. 83 , ( 10 ) 1345 - 1357 .

Boudjeniba C, Soret P, Trutschel D, Hamon A, Baloche V, Chassagnol B, Desvaux E, Bichat A et al. ( 2024 ) . Consensus gene modules strategy identifies candidate blood-based biomarkers for primary Sjögren's disease . Clinical Immunology vol. 264 ,

Gandolfo S, Bombardieri M, Pers J-O, Mariette X, Ciccia F ( 2024 ) . Precision medicine in Sjögren's disease . The Lancet Rheumatology vol. 6 , ( 9 ) e636 - e647 .

Lyon M, Zhao SS, Jani M, Chinoy H, Barton A, Bluett J, Bluett J, Chelliah EG et al. ( 2024 ) . The influence of deprivation in the outcomes of psoriatic arthritis within the UK—utilizing Outcomes of Treatment in Psoriatic Arthritis Study Syndicate (OUTPASS) data . Rheumatology Advances in Practice vol. 8 , ( 2 )

Corsiero E, Caliste M, Jagemann L, Fossati-Jimack L, Goldmann K, Cubuk C, Ghirardi GM, Prediletto E et al. ( 2024 ) . Autoimmunity to stromal-derived autoantigens in rheumatoid ectopic germinal centers exacerbates arthritis and affects clinical response . Journal of Clinical Investigation vol. 134 , ( 12 )

Nerviani A, Boutet M-A, Ghirardi GM, Goldmann K, Sciacca E, Rivellese F, Pontarini E, Prediletto E et al. ( 2024 ) . Axl and MerTK regulate synovial inflammation and are modulated by IL-6 inhibition in rheumatoid arthritis . Nature Communications vol. 15 , ( 1 )

Pontarini E, Sciacca E, Chowdhury F, Grigoriadou S, Rivellese F, Murray‐Brown WJ, Lucchesi D, Fossati‐Jimack L et al. ( 2024 ) . Serum and Tissue Biomarkers Associated With Composite of Relevant Endpoints for Sjögren Syndrome (CRESS) and Sjögren Tool for Assessing Response (STAR) to B Cell–Targeted Therapy in the Trial of Anti–B Cell Therapy in Patients With Primary Sjögren Syndrome (TRACTISS) . Arthritis & Rheumatology vol. 76 , ( 5 ) 763 - 776 .

Colafrancesco S, Simoncelli E, Priori R, Bombardieri M ( 2023 ) . The pathogenic role of metabolism in Sjögren's syndrome . Clinical and Experimental Rheumatology vol. 41 , ( 12 ) 2538 - 2546 .

Duquesne J, Basseto L, Barnes M, Pontarini E, Adam C, Lazure T, Bombardieri M, Gallagher-Syed A et al. ( 2023 ) . Un modèle d’intelligence artificielle prédit le focus score et le diagnostic de la maladie de Sjögren à partir de biopsies de glandes salivaires . Revue du Rhumatisme vol. 90 ,

Rivellese F, Nerviani A, Giorli G, Warren L, Jaworska E, Bombardieri M, Lewis MJ, Humby F et al. ( 2023 ) . Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials . The Lancet Rheumatology vol. 5 , ( 11 ) e648 - e659 .

Fu H, Vuononvirta J, Fanti S, Bonacina F, D’Amati A, Wang G, Poobalasingam T, Fankhaenel M et al. ( 2023 ) . The Glucose Transporter 2 regulates CD8+ T cell function via environment sensing . Nature Metabolism

Berry JS, Tarn J, Casement J, Duret P-M, Scott L, Wood K, Johnsen S-J, Nordmark G et al. ( 2023 ) . Examining the biological pathways underlying clinical heterogeneity in Sjogren’s syndrome: proteomic and network analysis . Annals of the Rheumatic Diseases vol. 83 , ( 1 ) 88 - 95 .

Baldini C, Berardicurti O, Giacomelli R, Bombardieri M ( 2023 ) . Is minor salivary gland biopsy still mandatory in Sjogren's syndrome? Does seronegative Sjogren's syndrome exist? . Autoimmunity Reviews vol. 23 , ( 1 )

Rivellese F, Currado D, Giorli G, Prediletto E, Nerviani A, Khmelevskaya A, Micheroli R, Ospelt C et al. ( 2023 ) . AB0340 MULTI-DRUG RESISTANT RA IS ASSOCIATED WITH HIGHER BASELINE DISEASE ACTIVITY, MULTI-MORBIDITY, AND LOWER QUALITY OF LIFE: ANALYSES FROM THE R4RA BIOPSY-DRIVEN CLINICAL TRIAL . 1353 - 1354 .

Basseto L, Duquesne J, Bouget V, Barnes M, Pontarini E, Gallagher-Syed A, Bombardieri M, Fisher B et al. ( 2023 ) . OP0232 DEEP LEARNING ACCURATELY PREDICTS FOCUS SCORE AND DIAGNOSIS OF PRIMARY SJÖGREN SYNDROME USING LABIAL SALIVARY GLAND BIOPSIES . Conference: Scientific Abstracts152.2 - 15153 .

Pontarini E, Lucchesi D, Goldmann K, Lewis M, Song Q, Thomas E, Hao LY, Sivils K et al. ( 2023 ) . POS0292 TRANSCRIPTOMIC PROFILING OF SJOGREN’S SALIVARY GLANDS IDENTIFIES FOLLICULAR AND EXTRA-FOLLICULAR GENE SIGNATURES ASSOCIATED WITH RHEUMATOID FACTOR SEROPOSITIVITY . 388.2 - 38388 .

Mancuso S, Giacomassi C, Truglia S, Barbati C, Alessandri C, Corsiero E, Caliste M, Lewis M et al. ( 2023 ) . POS1425 ANTIB2GLYCOPROTEIN I ANTIBODIES CAN INDUCE NETOSIS . 1066.2 - 101066 .

Mauro D, Manou-Stathopoulou S, Rivellese F, Sciacca E, Goldmann K, Tsang V, Lucey-Clayton I, Pagani S et al. ( 2023 ) . UBE2L3 regulates TLR7-induced B cell autoreactivity in Systemic Lupus Erythematosus . Journal of Autoimmunity vol. 136 ,

Baldini C, Bartoloni E, Bombardieri M ( 2022 ) . Highlights of the 15th International Symposiumon Sjögren's Syndrome . Clinical and Experimental Rheumatology vol. 40 , ( 12 ) 2201 - 2210 .

Seror R, Baron G, Cornec D, Perrodeau E, Camus M, Bowman S, Bombardieri M, Bootsma H et al. ( 2022 ) . Performance du nouveau critère de réponse du syndrome de Sjögren primitif (SSp), le STAR (Sjögren's tool for assessing response) : réanalyse de 9 essais cliniques dans le SSp . Revue du Rhumatisme vol. 89 , a102 - a103 .

Fanti S, Stephenson E, Rocha-Vieira E, Protonotarios A, Kanoni S, Shahaj E, Longhi MP, Vyas VS et al. ( 2022 ) . Circulating c-Met–Expressing Memory T Cells Define Cardiac Autoimmunity . Circulation vol. 146 , ( 25 ) 1930 - 1945 .

Shikh MEME, Sayed RE, Aly NAR, Prediletto E, Hands R, Fossati-Jimack L, Bombardieri M, Lewis MJ et al. ( 2022 ) . Follicular dendritic cell differentiation is associated with distinct synovial pathotype signatures in rheumatoid arthritis . Frontiers in Medicine vol. 9 ,

Humby F, Durez P, Buch MH, Lewis MJ, Bombardieri M, John C, Rizvi H, Warren L et al. ( 2022 ) . Rituximab versus tocilizumab and B-cell status in TNF-alpha inadequate-responder rheumatoid arthritis patients:the R4-RA RCT . Efficacy and Mechanism Evaluation vol. 9 , ( 7 ) 1 - 58 .

Carlotti E, Murray-Brown W, Blighe K, Caliste M, Astorri E, Sutcliffe N, Tappuni AR, Pitzalis C et al. ( 2022 ) . High-throughput sequencing of IgH gene in minor salivary glands from Sjögren's syndrome patients reveals dynamic B cell recirculation between ectopic lymphoid structures . Clinical and Experimental Rheumatology vol. 40 , ( 12 ) 2363 - 2372 .

Cooles FAH, Tarn J, Lendrem DW, Naamane N, Lin CM, Millar B, Maney NJ, Anderson AE et al. ( 2022 ) . Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming . Annals of the Rheumatic Diseases vol. 81 , ( 9 ) 1214 - 1223 .

Surace A, Sciacca E, Goldmann K, Rivellese F, Cubuk C, Giorli G, Fossati-Jimack L, Ahmed M et al. ( 2022 ) . OP0077 SYNOVIAL RNA-SEQ ANALYSIS OF THE R4RA TRIAL IDENTIFIES SIGNATURES OF TREATMENT RESISTANCE AND REFRACTORY STATE IN RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases vol. 81 , ( Suppl 1 ) 52.2 - 5253 .

Rivellese F, Cubuk C, Surace A, Goldmann K, Sciacca E, Giorli G, Nerviani A, Fossati-Jimack L et al. ( 2022 ) . OP0085 CELL LINEAGE-SPECIFIC TRANSCRIPT DECONVOLUTION OF SYNOVIAL BIOPSIES FROM THE R4RA TRIAL IDENTIFIES CELL POPULATIONS ASSOCIATED WITH RESPONSE TO RITUXIMAB AND TOCILIZUMAB . Annals of the Rheumatic Diseases vol. 81 , ( Suppl 1 ) 56.2 - 5657 .

Prediletto E, Cubuk C, Pontarini E, Rivellese F, Nerviani A, Lucchesi D, Caliste M, Corsiero E et al. ( 2022 ) . POS0138 RHEUMATOID SYNOVIAL FIBROBLASTS DISPLAY IMPRINTED MEMORY OF THEIR SYNOVIAL ENDOTYPE WHICH CAN BE PLASTICALLY MODULATED BY B-CELLS CROSSTALK . Annals of the Rheumatic Diseases vol. 81 , ( Suppl 1 ) 296.1 - 29296 .

Pontarini E, Chowdhury F, Sciacca E, Grigoriadou S, Murray-Brown W, Rivellese F, Lucchesi D, Goldmann K et al. ( 2022 ) . POS0145 CLINICAL RESPONSE TO RITUXIMAB IS ASSOCIATED WITH PREVENTION OF B-CELL DRIVEN SALIVARY GLAND INFLAMMATION AND EPITHELIAL RESTORATION AS REVEALED BY MOLECULAR PATHOLOGY: RESULTS FROM THE TRACTISS TRIAL IN PRIMARY SJOGREN’S SYNDROME . Annals of the Rheumatic Diseases . vol. 81 , 299.2 - 29300 .

Corsiero E, Caliste M, Jagemann L, Prediletto E, Pitzalis C, Bombardieri M ( 2022 ) . POS0399 CHARACTERIZATION OF HSP60, A STROMAL-DERIVED AUTOANTIGEN, RECOGNIZED BY RA SYNOVIAL RECOMBINANT MONOCLONAL ANTIBODIES . Annals of the Rheumatic Diseases vol. 81 , ( Suppl 1 ) 456.1 - 45456 .

Elshikh M, El Sayed R, Aly N, Prediletto E, Hands R, Fossati-Jimack L, Bombardieri M, Lewis M et al. ( 2022 ) . POS0431 PDGF-BB, TNF-α, AND LT-β REGULATE FOLLICULAR DENDRITIC CELL DEVELOPMENT IN THE RHEUMATOID SYNOVIUM . Annals of the Rheumatic Diseases vol. 81 , ( Suppl 1 ) 470.1 - 47470 .

Caliste M, Prediletto E, Corsiero E, Jagemann L, Pitzalis C, Bombardieri M ( 2022 ) . POS0439 STROMAL B-CELL CROSSTALK PROMOTES THE ESTABLISHMENT OF SYNOVIAL B CELL NICHES THROUGH THE SELECTION, ACTIVATION OF NATURALLY OCCURRING EBV+ B CELLS . Annals of the Rheumatic Diseases vol. 81 , ( Suppl 1 ) 474.2 - 47475 .

Nerviani A, Boutet MA, Ghirardi GM, Goldmann K, Sciacca E, Rivellese F, Pontarini E, Caliste M et al. ( 2022 ) . POS0441 IN-DEPTH ANALYSIS OF Axl AND MerTK EXPRESSION PATTERNS AND REGULATION BY BIOLOGIC TREATMENTS IN RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases . vol. 81 , 475.2 - 47476 .

Rivellese F, Surace AEA, Goldmann K, Sciacca E, Çubuk C, Giorli G, John CR, Nerviani A et al. ( 2022 ) . Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial . Nature Medicine vol. 28 , ( 6 ) 1256 - 1268 .

Isaacs JD, Brockbank S, Pedersen AW, Hilkens C, Anderson A, Stocks P, Lendrem D, Tarn J et al. ( 2022 ) . RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients . Scientific Data vol. 9 , ( 1 )

Nayar S, Pontarini E, Campos J, Berardicurti O, Smith CG, Asam S, Gardner DH, Colafrancesco S et al. ( 2022 ) . Immunofibroblasts regulate LTα3 expression in tertiary lymphoid structures in a pathway dependent on ICOS/ICOSL interaction . Communications Biology vol. 5 , ( 1 )

Meednu N, Rangel-Moreno J, Zhang F, Escalera-Rivera K, Corsiero E, Prediletto E, DiCarlo E, Goodman S et al. ( 2022 ) . Dynamic spectrum of ectopic lymphoid B cell activation and hypermutation in the RA synovium characterized by NR4A nuclear receptor expression . Cell Reports vol. 39 , ( 5 )

Seror R, Baron G, Camus M, Cornec D, Perrodeau E, Bowman SJ, Bombardieri M, Bootsma H et al. ( 2022 ) . Development and preliminary validation of the Sjögren’s Tool for Assessing Response (STAR): a consensual composite score for assessing treatment effect in primary Sjögren’s syndrome . Annals of the Rheumatic Diseases vol. 81 , ( 7 ) 979 - 989 .

Hernández-Molina G, Kostov B, Brito-Zerón P, Vissink A, Mandl T, Hinrichs AC, Quartuccio L, Baldini C et al. ( 2022 ) . Characterization and outcomes of 414 patients with primary SS who developed haematological malignancies . Rheumatology vol. 62 , ( 1 ) 243 - 255 .

Price E, Bombardieri M, Kivitz A, Matzkies F, Gurtovaya O, Pechonkina A, Jiang W, Downie B et al. ( 2022 ) . Safety and efficacy of filgotinib, lanraplenib and tirabrutinib in Sjögren’s syndrome: a randomized, phase 2, double-blind, placebo-controlled study . Rheumatology vol. 61 , ( 12 ) 4797 - 4808 .

Vomero M, Caliste M, Barbati C, Speziali M, Celia AI, Ucci F, Ciancarella C, Putro E et al. ( 2022 ) . Tofacitinib Decreases Autophagy of Fibroblast-Like Synoviocytes From Rheumatoid Arthritis Patients . Frontiers in Pharmacology vol. 13 ,

Pezoulas VC, Goules A, Kalatzis F, Chatzis L, Kourou KD, Venetsanopoulou A, Exarchos TP, Gandolfo S et al. ( 2022 ) . Addressing the clinical unmet needs in primary Sjögren’s Syndrome through the sharing, harmonization and federated analysis of 21 European cohorts . Computational and Structural Biotechnology Journal vol. 20 , 471 - 484 .

Goules AV, Pezoulas VC, Kalatzis F, Chatzis L, Kourou K, Venetsano-Poulou A, Exarchos TP, Gandolfo S et al. ( 2022 ) . LYMPHOMA ASSOCIATED RISK FACTORS IN PRIMARY SJOGREN'S SYNDROME BY DATA DRIVEN ANALYSIS IN HARMONIZED PATIENTS . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY . vol. 40 , 45 - 46 .

Rivellese F, Pontarini E, Cubuk C, Nerviani A, Fossati-Jimack L, Surace A, Sciacca E, Goldmann K et al. ( 2022 ) . Module Signatures of Synovial Single-cell States Identify Disease Phenotypes in Early Treatment-naive Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 74 , 3345 - 3347 .

Goules AV, Pezoulas VC, Kalatzis F, Chatzis L, Kourou KD, Venetsanopoulou A, Exarchos TP, Gandolfo S et al. ( 2022 ) . PALPABLE PURPURA ASSOCIATED RISK FACTORS IN PRIMARY SJOGREN'S SYNDROME BY DATA DRIVEN ANALYSIS IN HARMONIZED PATIENTS . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY . vol. 40 , 36 - 36 .

Pontarini E, Chowdhury F, Sciacca E, Grigoriadou S, Emery P, Ng WF, Sutcliffe N, Rivellese F et al. ( 2022 ) . RITUXIMAB PREVENTS WORSENING OF B-CELL DRIVEN SALIVARY GLAND INFLAMMATION AND EXCRETORY FUNCTION IN PRIMARY SJOGREN'S SYNDROME: RESULTS FROM THE TRACTISS TRIAL . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY . vol. 40 , 91 - 92 .

Prediletto E, Cubuk C, Pontarini E, Rivellese F, Nerviani A, Lucchesi D, Caliste M, Corsiero E et al. ( 2022 ) . Rheumatoid Synovial Fibroblasts Display Imprinted Memory of Their Synovial Endotype Which Can Be Plastically Modulated by B-cells Crosstalk . ARTHRITIS & RHEUMATOLOGY . vol. 74 , 1242 - 1244 .

Seror R, Baron G, Cornec D, Perrodeau E, Camus M, Bowman SJ, Bombardieri M, Bootsma H et al. ( 2022 ) . THE SJOGREN'S TOOL FOR ASSESSING RESPONSE (STAR): ASSESSMENT OF RESPONSE RATES OVERALL, ACCORDING TO BASELINE ACTIVITY AND BY DOMAIN: REANALYSIS OF 9 CLINICAL TRIALS IN PRIMARY SJOGREN'S SYNDROME . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY . vol. 40 , 63 - 64 .

Seror R, Baron G, Cornec D, Perrodeau E, Camus M, Bowman S, Bombardieri M, Bootsma H et al. ( 2022 ) . The Sjogren Tool for Assessing Response (STAR): Assessment of Response Rates Overall, According to Baseline Activity and by Domain: Reanalysis of 9 Clinical Trials in Primary Sjogren Syndrome . ARTHRITIS & RHEUMATOLOGY . vol. 74 , 3235 - 3237 .

Retamozo S, Acar-Denizli N, Horváth IF, Ng W-F, Rasmussen A, Dong X, Li X, Baldini C et al. ( 2021 ) . Influence of the age at diagnosis in the disease expression of primary Sjögren syndrome. Analysis of 12,753 patients from the Sjögren Big Data Consortium . Clinical and Experimental Rheumatology vol. 39 Suppl 133 , ( 6 ) 166 - 174 .

Chowdhury F, Grigoriadou S, Bombardieri M ( 2021 ) . Severity of COVID-19 infection in primary Sjögren's syndrome and the emerging evidence of COVID-19-induced xerostomia . Clinical and Experimental Rheumatology vol. 39 Suppl 133 , ( 6 ) 215 - 222 .

Pontarini E, Coleby R, Bombardieri M ( 2021 ) . Cellular and molecular diversity in Sjogren’s syndrome salivary glands: Towards a better definition of disease subsets . Seminars in Immunology vol. 58 ,

Iqbal AJ, Krautter F, Blacksell IA, Wright RD, Austin‐Williams SN, Voisin M, Hussain MT, Law HL et al. ( 2021 ) . Galectin‐9 mediates neutrophil capture and adhesion in a CD44 and β2 integrin‐dependent manner . The FASEB Journal vol. 36 , ( 1 )

de Wolff L, Arends S, Pontarini E, Bombardieri M, Bowman SJ, Bootsma H ( 2021 ) . Development and performance of the Clinical Trials ESSDAI (ClinTrialsESSDAI), consisting of frequently active clinical domains, in two randomised controlled trials in primary Sjögren's syndrome . Clinical and Experimental Rheumatology vol. 39 Suppl 133 , ( 6 ) 100 - 106 .

Coleby R, Lucchesi D, Pontarini E, Pitzalis C, Bombardieri M ( 2021 ) . Stepwise changes in the murine salivary gland immune response during virally-induced ectopic lymphoid structure formation . Clinical and Experimental Rheumatology vol. 39 Suppl 133 , ( 6 ) 39 - 48 .

Pontarini E, Chowdhury F, Sciacca E, Grigoriadou S, Rivellese F, Lucchesi D, Goldmann K, Fossati-Jimack L et al. ( 2021 ) . OP0136 RITUXIMAB PREVENTS THE PROGRESSION OF B-CELL DRIVEN INFLAMMATORY INFILTRATE IN THE MINOR SALIVARY GLANDS OF PRIMARY SJOGREN’S SYNDROME BY DOWNREGULATING IMMUNOLOGICAL PATHWAYS KEY IN ECTOPIC GERMINAL CENTRE ORGANIZATION: RESULTS FROM THE TRACTISS TRIAL . Annals of the Rheumatic Diseases vol. 80 , ( Suppl 1 ) 79 - 80 .

Pontarini E, Sciacca E, Grigoriadou S, Rivellese F, Lucchesi D, Fossati-Jimack L, Coleby R, Chowdhury F et al. ( 2021 ) . NKp30 Receptor Upregulation in Salivary Glands of Sjögren’s Syndrome Characterizes Ectopic Lymphoid Structures and Is Restricted by Rituximab Treatment . Frontiers in Immunology vol. 12 ,

Chowdhury F, Tappuni A, Bombardieri M ( 2021 ) . Biological Therapy in Primary Sjögren's Syndrome: Effect on Salivary Gland Function and Inflammation . Frontiers in Medicine vol. 8 ,

Delvecchio FR, Fincham REA, Spear S, Clear A, Roy-Luzarraga M, Balkwill FR, Gribben JG, Bombardieri M et al. ( 2021 ) . Pancreatic Cancer Chemotherapy Is Potentiated by Induction of Tertiary Lymphoid Structures in Mice . Cellular and Molecular Gastroenterology and Hepatology vol. 12 , ( 5 ) 1543 - 1565 .

Arends S, de Wolff L, van Nimwegen JF, Verstappen GMPJ, Vehof J, Bombardieri M, Bowman SJ, Pontarini E et al. ( 2021 ) . Composite of Relevant Endpoints for Sjögren's Syndrome (CRESS): development and validation of a novel outcome measure . The Lancet Rheumatology vol. 3 , ( 8 ) e553 - e562 .

Rivellese F, Pontarini E, Fossati-Jimack L, Moura RA, Romão VC, Fonseca JE, Nerviani A, Cubuk C et al. ( 2021 ) . OP0011 INTEGRATION OF FLOW AND DIGITAL CYTOMETRY IN EARLY TREATMENT-NAÏVE RHEUMATOID ARTHRITIS IDENTIFIES DISTINCT IMMUNOPHENOTYPES IN PERIPHERAL BLOOD AND DISEASE TISSUE . Annals of the Rheumatic Diseases vol. 80 , ( Suppl 1 ) 7.2 - 7.7 .

Arends S, de Wolff L, Van Nimwegen JF, Verstappen GM, Vehof J, Bombardieri M, Bowman SJ, Pontarini E et al. ( 2021 ) . OP0130 COMPOSITE OF RELEVANT ENDPOINTS IN SJÖGREN’S SYNDROME (CRESS): A COMPREHENSIVE TOOL FOR CLINICAL TRIALS . Annals of the Rheumatic Diseases vol. 80 , ( Suppl 1 ) 74.1 - 7475 .

Meednu N, Rangel-Moreno J, Zhang F, Escalera-Rivera K, Corsiero E, Prediletto E, DiCarlo E, Goodman S et al. ( 2021 ) . Single cell analysis of RA synovial B cells reveals a dynamic spectrum of ectopic lymphoid B cell activation and hypermutation characterized by NR4A nuclear receptor expression .

Fanelli G, Romano M, Nova-Lamperti E, Sunderland MW, Nerviani A, Scottà C, Bombardieri M, Quezada SA et al. ( 2021 ) . PD-L1 signaling on human memory CD4+ T cells induces a regulatory phenotype . PLOS Biology vol. 19 , ( 4 )

Rivellese F, Manou-Stathopoulou S, Mauro D, Goldmann K, Pyne D, Rajakariar R, Gordon P, Schafer P et al. ( 2021 ) . Effects of targeting the transcription factors Ikaros and Aiolos on B cell activation and differentiation in systemic lupus erythematosus . Lupus Science & Medicine vol. 8 , ( 1 )

Retamozo S, Acar-Denizli N, Horvath IF, Ng W-F, Rasmussen A, Dong X, Li X, Baldini C et al. ( 2021 ) . Influence of the age at diagnosis in the disease expression of primary Sjogren's syndrome. Analysis of 12,753 patients from the Sjogren Big Data Consortium . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY vol. 39 , ( 6 ) S166 - S174 .

de Wolff L, Arends S, Pontarini E, Bombardieri M, Bowman SJ, Bootsma H ( 2021 ) . Performance of the Clinical Trials ESSDAI (ClinTrialsESSDAI), an Adjusted ESSDAI Score, in Two Randomised Clinical Trials in Patients with Primary Sjogren's Syndrome . ARTHRITIS & RHEUMATOLOGY . vol. 73 , 646 - 649 .

Pontarini E, Chowdhury F, Sciacca E, Grigoriadou SA, Rivellese F, Lucchesi D, Goldmann K, Fossati-Jimack L et al. ( 2021 ) . Rituximab Prevents the Progression of B-cell Driven Inflammatory Infiltrate in the Minor Salivary Glands of Primary Sjogren's Syndrome by Downregulating Immunological Pathways Key in Ectopic Germinal Centre Organization: Results from the TRACTISS Trial . ARTHRITIS & RHEUMATOLOGY . vol. 73 , 2065 - 2066 .

Humby F, Durez P, Buch MH, Lewis MJ, Rizvi H, Rivellese F, Nerviani A, Giorli G et al. ( 2021 ) . Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial . The Lancet vol. 397 , ( 10271 ) 305 - 317 .

Price E, Allen A, Rauz S, Tappuni A, Sutcliffe N, Bombardieri M, Carty S, Ciurtin C et al. ( 2020 ) . The management of Sjögren's syndrome: British Society for Rheumatology guideline scope . Rheumatology

Giacomelli R, Afeltra A, Bartoloni E, Berardicurti O, Bombardieri M, Bortoluzzi A, Carubbi F, Caso F et al. ( 2020 ) . The growing role of precision medicine for the treatment of autoimmune diseases; results of a systematic review of literature and Experts’ Consensus . Autoimmunity Reviews vol. 20 , ( 2 )

Jimenez-Royo P, Bombardieri M, Ciurtin C, Kostapanos M, Tappuni AR, Jordan N, Saleem A, Fuller T et al. ( 2020 ) . Advanced imaging for quantification of abnormalities in the salivary glands of patients with primary Sjögren’s syndrome . Rheumatology vol. 60 , ( 5 )

Pontarini E, Verstappen GM, Grigoriadou S, Kroese FGM, Bootsma H, Bombardieri M ( 2020 ) . Blocking T cell co-stimulation in primary Sjögren's syndrome: rationale, clinical efficacy and modulation of peripheral and salivary gland biomarkers . Clinical and Experimental Rheumatology vol. 38 Suppl 126 , ( 4 ) 222 - 227 .

Bombardieri M, Argyropoulou OD, Ferro F, Coleby R, Pontarini E, Governato G, Lucchesi D, Fulvio G et al. ( 2020 ) . One year in review 2020: pathogenesis of primary Sjögren's syndrome . Clinical and Experimental Rheumatology vol. 38 Suppl 126 , ( 4 ) 3 - 9 .

Lucchesi D, Pontarini E, Donati V, Mandarano M, Sidoni A, Bartoloni E, Baldini C, Tappuni AR et al. ( 2020 ) . The use of digital image analysis in the histological assessment of Sjögren's syndrome salivary glands improves inter-rater agreement and facilitates multicentre data harmonisation . Clinical and Experimental Rheumatology vol. 38 Suppl 126 , ( 4 ) 180 - 188 .

Pontarini E, Murray-Brown WJ, Croia C, Lucchesi D, Conway J, Rivellese F, Fossati-Jimack L, Astorri E et al. ( 2020 ) . Unique expansion of IL-21+ Tfh and Tph cells under control of ICOS identifies Sjögren’s syndrome with ectopic germinal centres and MALT lymphoma . Annals of the Rheumatic Diseases vol. 79 , ( 12 ) 1588 - 1599 .

Lucchesi D, Coleby R, Pontarini E, Prediletto E, Rivellese F, Hill DG, Soria AD, Jones SA et al. ( 2020 ) . Impaired Interleukin‐27–Mediated Control of CD4+ T Cell Function Impact on Ectopic Lymphoid Structure Formation in Patients With Sjögren's Syndrome . Arthritis & Rheumatology vol. 72 , ( 9 ) 1559 - 1570 .

Nerviani A, Boutet MA, Ghirardi GM, Lliso Ribera G, Rivellese F, Lewis M, Bombardieri M, Humby F et al. ( 2020 ) . THU0082 MERTK SYNOVIAL EXPRESSION CORRELATES WITH TREATMENT RESPONSE IN RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases . vol. 79 , 253.1 - 25253 .

Nerviani A, Di Cicco M, Mahto A, Lliso-Ribera G, Rivellese F, Thorborn G, Hands R, Bellan M et al. ( 2020 ) . A Pauci-Immune Synovial Pathotype Predicts Inadequate Response to TNFα-Blockade in Rheumatoid Arthritis Patients . Frontiers in Immunology vol. 11 ,

Corsiero E, Carlotti E, Jagemann L, Perretti M, Pitzalis C, Bombardieri M ( 2020 ) . H and L Chain Affinity Maturation and/or Fab N-Glycosylation Influence Immunoreactivity toward Neutrophil Extracellular Trap Antigens in Rheumatoid Arthritis Synovial B Cell Clones . The Journal of Immunology vol. 204 , ( 9 )

Humby FC, Lewis M, Durez P, Buch MH, Bombardieri M, Rizvi H, Rivellese F, Fossati L et al. ( 2020 ) . O07 Randomised, open labelled clinical trial to investigate synovial mechanisms determining response: resistance to rituximab versus tocilizumab in RA patients failing TNF inhibitor therapy . Rheumatology . vol. 59 ,

Nerviani A, Lliso-Ribera G, Boutet M-A, Goldmann K, Rivellese F, Kelly S, Bombardieri M, Lewis M et al. ( 2020 ) . O20 Histological and molecular features of the diseased synovium in early untreated PsA in comparison with RA . Rheumatology . vol. 59 ,

Lucchesi D, Coleby R, Pontarini E, Prediletto E, Rivellese F, Hill D, Soria AD, Jones S et al. ( 2020 ) . O31 IL-27 regulates the magnitude of ectopic germinal centres in experimental sialadenitis but fails to modulate IL-17 and IFNg production in CD4 T cells from patients with Sjögren's syndrome . Rheumatology . vol. 59 ,

Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A et al. ( 2020 ) . P233 B cell-rich synovitis in early and established rheumatoid arthritis . Rheumatology vol. 59 , ( Supplement_2 )

Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A et al. ( 2020 ) . B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure . Arthritis and Rheumatology

Fisher BA, Szanto A, Ng W-F, Bombardieri M, Posch MG, Papas AS, Farag AM, Daikeler T et al. ( 2020 ) . Assessment of the anti-CD40 antibody iscalimab in patients with primary Sjögren's syndrome: a multicentre, randomised, double-blind, placebo-controlled, proof-of-concept study . The Lancet Rheumatology vol. 2 , ( 3 ) e142 - e152 .

Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A et al. ( 2020 ) . B CELL-RICH SYNOVITIS IN EARLY AND ESTABLISHED RHEUMATOID ARTHRITIS . RHEUMATOLOGY . vol. 59 ,

Pontarini E, Verstappen GM, Grigoriadou S, Kroese FGM, Bootsma H, Bombardieri M ( 2020 ) . Blocking T cell co-stimulation in primary Sjogren's syndrome: rationale, clinical efficacy and modulation of peripheral and salivary gland biomarkers . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY vol. 38 , ( 4 ) S222 - S227 .

Nerviani A, Lliso-Ribera G, Boutet M-A, Goldmann K, Rivellese F, Kelly S, Bombardieri M, Lewis M et al. ( 2020 ) . HISTOLOGICAL AND MOLECULAR FEATURES OF THE DISEASED SYNOVIUM IN EARLY UNTREATED PSA IN COMPARISON WITH RA . RHEUMATOLOGY . vol. 59 ,

Lucchesi D, Coleby R, Pontarini E, Prediletto E, Rivellese F, Hill D, Soria AD, Jones S et al. ( 2020 ) . IL-27 REGULATES THE MAGNITUDE OF ECTOPIC GERMINAL CENTRES IN EXPERIMENTAL SIALADENITIS BUT FAILS TO MODULATE IL-17 AND IFNG PRODUCTION IN CD4 T CELLS FROM PATIENTS WITH SJOGREN'S SYNDROME . RHEUMATOLOGY . vol. 59 ,

Nerviani A, Boutet M-A, Ghirardi GM, Lliso-Ribera G, Rivellese F, Lewis M, Bombardieri M, Humby F et al. ( 2020 ) . MerTK Synovial Expression Correlates with Disease Activity and Treatment Response in Rheumatoid Arthritis Patients . ARTHRITIS & RHEUMATOLOGY . vol. 72 ,

Bombardieri M, Argyropoulou OD, Ferro F, Coleby R, Pontarini E, Governato G, Lucchesi D, Fulvio G et al. ( 2020 ) . One year in review 2020: pathogenesis of primary Sjogren's syndrome . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY vol. 38 , ( 4 ) S3 - S9 .

Humby FC, Lewis M, Durez P, Buch MH, Bombardieri M, Rizvi H, Rivellese F, Fossati L et al. ( 2020 ) . RANDOMISED, OPEN LABELLED CLINICAL TRIAL TO INVESTIGATE SYNOVIAL MECHANISMS DETERMINING RESPONSE: RESISTANCE TO RITUXIMAB VERSUS TOCILIZUMAB IN RA PATIENTS FAILING TNF INHIBITOR THERAPY . RHEUMATOLOGY . vol. 59 , 3 - + .

Meednu N, Zhang F, Escalera-Rivera K, Corsiero E, Prediletto E, Bombardieri M, DiCarlo E, Orange D et al. ( 2020 ) . Role of NR4A Nuclear Receptor Family in RA Synovial Ectopic Lymphoid Neogenesis Revealed by Single Cell Profiling . ARTHRITIS & RHEUMATOLOGY . vol. 72 ,

Lucchesi D, Pontarini E, Donati V, Mandarano M, Sidoni A, Bartoloni E, Baldini C, Tappuni AR et al. ( 2020 ) . The use of digital image analysis in the histological assessment of Sjogren's syndrome salivary glands improves inter-rater agreement and facilitates multicentre data harmonisation . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY vol. 38 , ( 4 ) S180 - S188 .

Brito-Zerón P, Acar-Denizli N, Ng W-F, Horváth IF, Rasmussen A, Seror R, Li X, Baldini C et al. ( 2019 ) . Epidemiological profile and north–south gradient driving baseline systemic involvement of primary Sjögren’s syndrome . Rheumatology vol. 59 , ( 9 ) 2350 - 2359 .

Pucino V, Certo M, Bulusu V, Cucchi D, Goldmann K, Pontarini E, Haas R, Smith J et al. ( 2019 ) . Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring . Cell Metabolism

Tarn JR, Howard-Tripp N, Lendrem DW, Mariette X, Saraux A, Devauchelle-Pensec V, Seror R, Skelton AJ et al. ( 2019 ) . Symptom-based stratification of patients with primary Sjögren's syndrome: multi-dimensional characterisation of international observational cohorts and reanalyses of randomised clinical trials . The Lancet Rheumatology vol. 1 , ( 2 ) e85 - e94 .

Grigoriadou S, Chowdhury F, Pontarini E, Tappuni A, Bowman SJ, Bombardieri M ( 2019 ) . B-cell depletion with rituximab in the treatment of primary Sjögren's syndrome: What have we learnt? . Clinical and Experimental Rheumatology vol. 37 , S217 - S224 .

Lewis MJ, Barnes MR, Blighe K, Goldmann K, Rana S, Hackney JA, Ramamoorthi N, John CR et al. ( 2019 ) . Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes . Cell Reports vol. 28 , 2455 - 2470 .

Retamozo S, Acar-Denizli N, Rasmussen A, Horváth IF, Baldini C, Priori R, Sandhya P, Hernandez-Molina G et al. ( 2019 ) . Systemic manifestations of primary Sjögren's syndrome out of the ESSDAI classification: Prevalence and clinical relevance in a large international, multi-ethnic cohort of patients . Clinical and Experimental Rheumatology vol. 37 , S97 - S106 .

Acar-Denizli N, Kostov B, Ramos-Casals M ( 2019 ) . The Big Data Sjögren Consortium: a project for a new data science era . Clinical and Experimental Rheumatology vol. 37 Suppl 118 , ( 3 ) 19 - 23 .

Colafrancesco S, Priori R, Smith CG, Minniti A, Iannizzotto V, Pipi E, Lucchesi D, Pontarini E et al. ( 2019 ) . CXCL13 as biomarker for histological involvement in Sjögren’s syndrome . Rheumatology vol. 59 , ( 1 ) 165 - 170 .

Davies K, Mirza K, Tarn J, Howard-Tripp N, Bowman SJ, Lendrem D, Ng W-F ( 2019 ) . Fatigue in primary Sjögren’s syndrome (pSS) is associated with lower levels of proinflammatory cytokines: a validation study . Rheumatology International vol. 39 , ( 11 ) 1867 - 1873 .

Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Ribera GL, Nerviani A et al. ( 2019 ) . THU0058 B CELL SYNOVITIS AND CLINICAL PHENOTYPES IN RHEUMATOID ARTHRITIS AT DIFFERENT DISEASE STAGES . https://ard.bmj.com/content/78/Suppl_2 . Conference: Annual European Congress of Rheumatology, EULAR 2019 ( Madrid ) from: 12/06/2019 to: 15/06/2019 , 296.2 - 29297 .

Vomero M, Caliste M, Barbati C, Colasanti T, Spinelli F, Ceccarelli F, Perricone C, Finucci A et al. ( 2019 ) . AB0145 THE INHIBITION OF JAK PATHWAY WAS ASSOCIATED WITH REDUCTION OF AUTOPHAGY IN SYNOVIOCYTES FROM RHEUMATOID ARTHRITIS PATIENTS . Conference: Abstracts Accepted for Publication1530.3 - 151531 .

Manou-Stathopoulou S, Rivellese F, Mauro D, Goldmann K, Pyne D, Schafer P, Bombardieri M, Pitzalis C et al. ( 2019 ) . AB0179 THE TRANSCRIPTION FACTORS IKZF1 AND IKZF3 CONTROL B CELL ACTIVATION AND DIFFERENTIATION IN SYSTEMIC LUPUS ERYTHEMATOSUS . Conference: Abstracts Accepted for Publication1548.1 - 151548 .

Bombardieri M, Ciurtin C, Kostapanos M, Astorri E, Tappuni A, Jordan N, Azeem S, Fuller T et al. ( 2019 ) . AB0496  18 F-FDG-PET/CT, 11 C-METHIONINE-PET/CT AND MULTI-PARAMETRIC MRI IN THE EVALUATION OF DISEASE ACTIVITY AND GLAND FUNCTION IN PRIMARY SJÖGREN’S SYNDROME . Conference: Abstracts Accepted for Publication1711.2 - 171711 .

Retamozo S, Acar-Denizli N, Ng WF, Horváth IF, Rasmussen A, Seror R, Xiaomei L, Baldini C et al. ( 2019 ) . AB0550 PHENOTYPE OF BIOPSY-PROVEN PATIENTS WITH PRIMARY SJÖGREN SYNDROME LACKING RO AUTOANTIBODIES: HIGH FREQUENCY OF DRYNESS SYMPTOMS WITH LOW SYSTEMIC ACTIVITY (BIG DATA SJÖGREN PROJECT) . Conference: Abstracts Accepted for Publication1736.2 - 171737 .

Fisher B, Szántó A, Ng WF, Bombardieri M, Posch M, Papas A, Farag A, Daikeler T et al. ( 2019 ) . FRI0174 SUBCUTANEOUS DOSING OF THE NOVEL ANTI-CD40 ANTIBODY ISCALIMAB ACHIEVES TARGET DRUG EXPOSURE AND CLINICAL EFFICACY IN PRIMARY SJÖGREN’S SYNDROME; RESULTS OF A PHASE IIA RANDOMISED OPEN LABEL TWO ARM PARALLEL GROUP TRIAL . Conference: Poster Presentations760.2 - 76761 .

Nerviani A, Ribera GL, Boutet MA, Goldmann K, Kelly S, Bombardieri M, Lewis M, Humby F et al. ( 2019 ) . OP0113 HISTOLOGICAL AND MOLECULAR PORTRAIT OF THE SYNOVIAL TISSUE IN EARLY TREATMENT-NAÏVE PSORIATIC ARTHRITIS IN COMPARISON WITH RHEUMATOID ARTHRITIS . Conference: Oral Presentations130 - 131 .

Ribera GL, Humby F, Nerviani A, Lewis M, Kelly S, Bombardieri M, Goldmann K, Hands R et al. ( 2019 ) . OP0120 BASELINE CELLULAR AND MOLECULAR CHARACTERISTICS OF SYNOVIAL TISSUE AND RELATION WITH TNFI RESPONSE. RESULTS FROM THE PATHOBIOLOGY OF THE EARLY ARTHRITIS COHORT (PEAC) . Conference: Oral Presentations134 - 134 .

Lucchesi D, Coleby R, Pontarini E, Prediletto E, Hill D, Soria AD, Rivellese F, Pitzalis C et al. ( 2019 ) . OP0276 DENDRITIC CELL-DERIVED IL-27 REGULATES THE MAGNITUDE OF INDUCIBLE ECTOPIC GERMINAL CENTRES BUT FAILS TO DOWNMODULATE IL-17 PRODUCTION IN CD4 T CELLS FROM PATIENTS WITH SJÖGREN’S SYNDROME . Conference: Oral Presentations220.1 - 22220 .

Pontarini E, Brown WM, Croia C, Lucchesi D, Rivellese F, Fossati-Jimack L, Ruscitti P, Prediletto E et al. ( 2019 ) . OP0279 A UNIQUE IL-21 SIGNATURE CHARACTERIZES LESIONAL AND CIRCULATING T-FOLLICULAR HELPER CELLS IN SJÖGREN’S SYNDROME PATIENTS WITH ECTOPIC GERMINAL CENTRES AND MALT LYMPHOMA . Conference: Oral Presentations221.1 - 22221 .

Rivellese F, Manou-Stathopoulou S, Mauro D, Pontarini E, Lucchesi D, Congia M, Schafer P, Sutcliffe N et al. ( 2019 ) . THU0234 THE TRANSCRIPTION FACTORS IKAROS (IKZF1) AND AIOLOS (IKZF3) ARE EXPRESSED IN THE SALIVARY GLANDS OF SJÖGREN’S SYNDROME PATIENTS WITH LYMPHOID AGGREGATES AND MODULATE B CELL ACTIVATION IN VITRO . Conference: Poster Presentations394.2 - 39395 .

Retamozo S, Acar-Denizli N, Ng WF, Horváth IF, Rasmussen A, Seror R, Xiaomei L, Baldini C et al. ( 2019 ) . THU0277 HOW THE AGE AT DIAGNOSIS MODIFIES THE PHENOTYPE OF PRIMARY SJÖGREN SYNDROME: ANALYSIS IN 11,420 PATIENTS (BIG DATA SJÖGREN PROJECT) . Conference: Poster Presentations416.2 - 41417 .

Retamozo S, Acar-Denizli N, Ng WF, Szántó A, Rasmussen A, Seror R, Xiaomei L, Baldini C et al. ( 2019 ) . OP0126 LYMPHOMA ARISING AT THE TIME OF DIAGNOSIS OF PRIMARY SJÖGREN SYNDROME: A HIGHLY-ACTIVE SYSTEMIC SUBSET OF THE DISEASE . Conference: Oral Presentations138.1 - 13138 .

Hackett KL, Davies K, Tarn J, Bragg R, Hargreaves B, Miyamoto S, McMeekin P, Mitchell S et al. ( 2019 ) . Pain and depression are associated with both physical and mental fatigue independently of comorbidities and medications in primary Sjögren’s syndrome . RMD Open vol. 5 , ( 1 )

Manou-Stathopoulou S, Rivellese F, Mauro D, Goldmann K, Pyne D, Schafer P, Bombardieri M, Pitzalis C et al. ( 2019 ) . 235 IKZF1 and IKZF3 inhibition impairs B cell differentiation and modulates gene expression in systemic lupus erythematosus . Conference: Abstractsa174.2 - a1a175 .

HUMBY F ( 2019 ) . Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients . Annals of the Rheumatic Diseases

Nocturne G, Pontarini E, Bombardieri M, Mariette X ( 2019 ) . Lymphomas complicating primary Sjögren's syndrome: from autoimmunity to lymphoma . Rheumatology vol. 60 , ( 8 ) 3513 - 3521 .

Colafrancesco S, Priori R, Smith C, Minniti A, Iannizzotto V, Pipi E, Nayar S, Campos J et al. ( 2019 ) . P055 CXCL13 as biomarker for histological involvement in sjogren’s syndrome . Annals of the Rheumatic Diseases . Conference: Abstracts vol. 78 ,

Bottini A, Wu DJ, Ai R, Le Roux M, Bartok B, Bombardieri M, Doody KM, Zhang V et al. ( 2019 ) . PTPN14 phosphatase and YAP promote TGFβ signalling in rheumatoid synoviocytes . Annals of the Rheumatic Diseases vol. 78 , ( 5 ) 600 - 609 .

PITZALIS C, CORSIERO E, DELVECCHIO F, BOMBARDIERI M ( 2019 ) . B cells in the formation of Tertiary Lymphoid Organs in autoimmunity, transplantation and tumorigenesis . Current Opinion in Immunology vol. 57 , 46 - 52 .

Vomero M, Manganelli V, Barbati C, Colasanti T, Capozzi A, Finucci A, Spinelli FR, Ceccarelli F et al. ( 2019 ) . Reduction of autophagy and increase in apoptosis correlates with a favorable clinical outcome in patients with rheumatoid arthritis treated with anti-TNF drugs . Arthritis Research & Therapy vol. 21 , ( 1 )

Mariette X, Bombardieri M, Alevizos I, Moate R, Sullivan B, Noaiseh G, Kvarnstrom M, Rees W et al. ( 2019 ) . A Phase 2a Study of MEDI5872 (AMG557), a Fully Human Anti-ICOS Ligand Monoclonal Antibody in Patients with Primary Sjogren's Syndrome . ARTHRITIS & RHEUMATOLOGY . vol. 71 ,

Humby F, Buch MH, Durez P, Lewis M, Bombardieri M, Rizvi H, Kelly S, Fosatti L et al. ( 2019 ) . A Randomised, Open Labelled Clinical Trial to Investigate Synovial Mechanisms Determining Response - Resistance to Rituximab versus Tocilizumab in Rheumatoid Arthritis Patients Failing TNF Inhibitor Therapy . ARTHRITIS & RHEUMATOLOGY . vol. 71 ,

Grigoriadou S, Chowdhury F, Pontarini E, Tappuni A, Bowman SJ, Bombardieri M ( 2019 ) . B-cell depletion with rituximab in the treatment of primary Sjogren's syndrome: what have we learnt? . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY vol. 37 , ( 3 ) S217 - S224 .

Corsiero E, Jagemann L, Perretti M, Pitzalis C, Bombardieri M ( 2019 ) . Characterization of calreticulin, a stromal-derived autoantigens, recognized by RA synovial recombinant monoclonal antibodies . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 49 , 773 - 774 .

Pucino V, Certo M, Bulusu V, Goldmann K, Cucchi D, Haas R, Smith J, Blighe K et al. ( 2019 ) . Lactate influx into human CD4+T-cells, via SLC5A12, causes STAT3-and fatty acid synthesis-mediated IL17 expression and tissue retention . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 49 , 1276 - 1277 .

Prediletto E, Pontarini E, Lucchesi D, Corsiero E, Pratesi F, Migliorini P, Pitzalis C, Bombardieri M ( 2019 ) . Synovial fluid fibroblast-like synoviocytes enhance long-term survival of EBV infected memory B cells in rheumatoid arthritis . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 49 , 791 - 791 .

Pontarini E, Lucchesi D, Fossati-Jimack L, Coleby R, Tentorio P, Croia C, Bombardieri M, Mavilio D ( 2018 ) . NK cell recruitment in salivary glands provides early viral control but is dispensable for tertiary lymphoid structure formation . Journal of Leukocyte Biology vol. 105 , ( 3 ) 589 - 602 .

Giacomelli R, Afeltra A, Alunno A, Bartoloni-Bocci E, Berardicurti O, Bombardieri M, Bortoluzzi A, Caporali R et al. ( 2018 ) . Guidelines for biomarkers in autoimmune rheumatic diseases - evidence based analysis . Autoimmunity Reviews vol. 18 , ( 1 ) 93 - 106 .

Consortium R-M ( 2018 ) . Novel methodology to discern predictors of remission and patterns of disease activity over time using rheumatoid arthritis clinical trials data . RMD Open vol. 4 , ( 2 )

Farag A, Papas A, Fisher B, Zeher M, Ng W-F, Bombardieri M, Posch M, Daikeler T et al. ( 2018 ) . Novel Anti-CD40 Monoclonal Antibody CFZ533 in Patients with Primary Sjogren Syndrome: A Phase Iia Double-Blind, Placebo–Controlled Randomized Trial . Oral Surgery Oral Medicine Oral Pathology and Oral Radiology . vol. 126 , e203 - e204 .

Corsiero E, Jagemann L, Bombardieri M, Pitzalis C ( 2018 ) . Generation of Recombinant Monoclonal Antibodies from Single B Cells Isolated from Synovial Tissue of Rheumatoid Arthritis Patients . Methods Mol Biol vol. 1845 , 159 - 187 .

Notarstefano C, Croia C, Pontarini E, Lucchesi D, Sutcliffe N, Tappuni A, Donati V, Pitzalis C et al. ( 2018 ) . A clinical and histopathological analysis of the anti-centromere antibody positive subset of primary Sjögren's syndrome . Clin Exp Rheumatol vol. 36 Suppl 112 , ( 3 ) 145 - 149 .

Brito-Zerón P, Acar-Denizli N, Ng W-F, Zeher M, Rasmussen A, Mandl T, Seror R, Li X et al. ( 2018 ) . How immunological profile drives clinical phenotype of primary Sjögren's syndrome at diagnosis: analysis of 10,500 patients (Sjögren Big Data Project) . Clinical and Experimental Rheumatology vol. 36 Suppl 112 , ( 3 ) 102 - 112 .

Kroese FGM, Haacke EA, Bombardieri M ( 2018 ) . The role of salivary gland histopathology in primary Sjögren's syndrome: promises and pitfalls . Clinical and Experimental Rheumatology vol. 36 Suppl 112 , ( 3 ) 222 - 233 .

Bombardieri M, Baldini C, Alevizos I, Akpek E, Baer AN ( 2018 ) . Highlights of the 14th International Symposium in Sjögren's Syndrome . Clinical and Experimental Rheumatology vol. 36 Suppl 112 , ( 3 ) 3 - 13 .

PITZALIS C, CORSIERO E, JAGEMANN L, PERRETTI M, BOMBARDIERI M ( 2018 ) . Characterization of a synovial B cell-derived 1 recombinant monoclonal antibody 2 targeting stromal calreticulin in the rheumatoid joints . Journal of Immunology

Manganelli V, Recalchi S, Capozzi A, Riitano G, Mattei V, Longo A, Di Franco M, Alessandri C et al. ( 2018 ) . Autophagy induces protein carbamylation in fibroblast-like synoviocytes from patients with rheumatoid arthritis . Rheumatology vol. 57 , ( 11 ) 2032 - 2041 .

Lliso-Ribera G, Humby F, Nerviani A, Boutet MA, Kelly S, Bombardieri M, Lewis M, Hands R et al. ( 2018 ) . OP0040 Synovial cell infiltration in acpa-ve patients displays similar signatures to other seronegative inflammatory arthritis. results from the pathobiology of early arthritis cohort (PEAC) . Annals of the Rheumatic Diseases . Conference: WEDNESDAY, 13 JUNE 2018 vol. 77 ,

Retamozo S, Acar-Denizli N, Ng WF, Zeher M, Rasmussen A, Seror R, Li X, Baldini C et al. ( 2018 ) . OP0120 Influence of epidemiology and ethnicity on systemic expression of primary sjÖgren syndrome in 9974 patients . Annals of the Rheumatic Diseases . Conference: THURSDAY, 14 JUNE 2018 vol. 77 ,

Retamozo S, Acar-Denizli N, Ng WF, Zeher M, Rasmussen A, Mandl T, Seror R, Li X et al. ( 2018 ) . SAT0457 SjÖgren big data project, the first example of data sharing in autoimmune diseases: analysis of 10475 worldwide patients . Annals of the Rheumatic Diseases . Conference: Saturday, 16 JUNE 2018 vol. 77 ,

Retamozo S, Acar-Denizli N, Ng WF, Zeher M, Rasmussen A, Seror R, Li X, Baldini C et al. ( 2018 ) . SAT0683 A north-south worldwide gradient in systemic activity of primary sjÖgren syndrome: increased severe disease in patients from southern countries . Annals of the Rheumatic Diseases . Conference: Saturday, 16 JUNE 2018 vol. 77 ,

Nerviani A, Mauro D, Pagani S, Lliso-Ribera G, Rivellese F, Lewis M, Bombardieri M, Humby F et al. ( 2018 ) . THU0061 Restricted axl synovial expression and increased cleavage of axl ectodomain correlate with highly inflamed synovitis and more severe rheumatoid arthritis . Annals of the Rheumatic Diseases . Conference: THURSDAY, 14 JUNE 2018 vol. 77 ,

Rivellese F, Congia M, Mauro D, Bombardieri M, Lewis M, Pitzalis C ( 2018 ) . THU0070 The transcription factors ikaros and aiolos are expressed in the synovial membrane of early rheumatoid arthritis patients in association with synovial lymphoid aggregates . Annals of the Rheumatic Diseases . Conference: THURSDAY, 14 JUNE 2018 vol. 77 ,

Cole S, Walsh A, Yin X, Wechalekar MD, Smith MD, Proudman SM, Veale DJ, Fearon U et al. ( 2018 ) . Integrative analysis reveals CD38 as a therapeutic target for plasma cell-rich pre-disease and established rheumatoid arthritis and systemic lupus erythematosus . Arthritis Research & Therapy vol. 20 , ( 1 )

Ribera GL, Humby F, Kelly S, Lewis M, Bombardieri M, Nerviani A, Hands R, Bene F et al. ( 2018 ) . 244 The clinical phenotype of inflammatory arthritis correlates with synovial immune cell infiltration: results from the pathobiology of early arthritis cohort . Rheumatology vol. 57 , ( suppl_3 )

Ribera GL, Humby F, Kelly S, Lewis M, Bombardieri M, Nerviani A, Hands R, Bene F et al. ( 2018 ) . O09 A lymphoid pathotype at baseline, in early inflammatory arthritis, significantly associates with requirement for biologic therapy at 12 months follow up: results from the pathobiology of early arthritis cohort . Rheumatology vol. 57 , ( suppl_3 )

Fisher BA, Emery P, Pitzalis C, Bombardieri M, Bowman SJ ( 2018 ) . Response to: Can ultrasound of the major salivary glands assess histopathological changes induced by treatment with rituximab in primary Sjögren’s syndrome? . Annals of the Rheumatic Diseases vol. 78 , ( 4 )

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Lucchesi D, Pontarini E, Coleby R, Jones G, Hill D, Pitzalis C, Bombardieri M ( 2018 ) . P079 Interleukin-27 regulates the magnitude of the ectopic germinal centre response in a viral-inducible model of sialadenitis . Annals of the Rheumatic Diseases . Conference: Poster presentations vol. 77 ,

Dumusc A, Ng W-F, James K, Griffiths B, Price E, Pease C, Emery P, Lanyon P et al. ( 2018 ) . Comparison of ESSDAI and ClinESSDAI in potential optimisation of trial outcomes in primary Sjögren’s syndrome: examination of data from the UK Primary Sjögren’s Syndrome Registry . Swiss Medical Weekly vol. 148 , ( 0506 )

Ribera GL, Humby F, Kelly S, Lewis M, Bombardieri M, Nerviani A, Hands R, Bene F et al. ( 2018 ) . A LYMPHOID PATHOTYPE AT BASELINE, IN EARLY INFLAMMATORY ARTHRITIS, SIGNIFICANTLY ASSOCIATES WITH REQUIREMENT FOR BIOLOGIC THERAPY AT 12 MONTHS FOLLOW UP: RESULTS FROM THE PATHOBIOLOGY OF EARLY ARTHRITIS COHORT . RHEUMATOLOGY . vol. 57 ,

Notarstefano C, Croia C, Pontarini E, Lucchesi D, Sutcliffe N, Tappuni A, Donati V, Pitzalis C et al. ( 2018 ) . A clinical and histopathological analysis of the anti-centromere antibody positive subset of primary Sjogren's syndrome . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY vol. 36 , ( 3 ) S145 - S149 .

Retamozo S, Hernandez-Molina G, Valim V, Moca Trevisani VF, Pasoto SG, Acar-Denizli N, Zeher M, Sivils K et al. ( 2018 ) . CLINICAL AND IMMUNOLOGICAL PRIMARY SJOGREN SYNDROME' DISEASE PATTERNS ARE DRIVEN BY GENDER AND AGE AT DIAGNOSIS . JCR-JOURNAL OF CLINICAL RHEUMATOLOGY . vol. 24 , S30 - S31 .

Retamozo S, Kostov B, Zeher M, Sivils K, Mandl T, Seror R, Li X, Baldini C et al. ( 2018 ) . Clinical and immunological disease patterns of primary Sjogren syndrome driven by gender and age at diagnosis . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY . vol. 36 , S269 - S270 .

Nerviani A, Humby F, Ribera GL, Tan WS, Boutet MA, Goldmann K, Bene F, Hands R et al. ( 2018 ) . Comparative Histologic and Molecular Analysis of Synovial Tissue in Early Treatment-Naive Psoriatic and Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 70 ,

Rivellese F, Mauro D, Congia M, Pontarini E, Schafer P, Bombardieri M, Pitzalis C, Lewis MJ ( 2018 ) . Expression and Functions of the Transcription Factors Ikaros and Aiolos in Sjogren's Syndrome and Systemic Lupus Erythematosus . ARTHRITIS & RHEUMATOLOGY . vol. 70 ,

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Retamozo S, Hernandez-Molina G, Valim V, Moca Trevisani VF, Pasoto SG, Acar-Denizli N, Zeher M, Sivils K et al. ( 2018 ) . HOW ETHNICITY MODIFIES SYSTEMIC ACTIVITY OF PRIMARY SJOGREN SYNDROME: ANALYSIS OF BASELINE ESSDAI SCORES IN A MULTI-ETHNIC INTERNATIONAL COHORT . JCR-JOURNAL OF CLINICAL RHEUMATOLOGY . vol. 24 , S31 - S32 .

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Lucchesi D, Pontarini E, Coleby R, Jones GW, Hill DG, Pitzalis C, Bombardieri M ( 2018 ) . Interleukin-27 regulates the magnitude of the ectopic germinal centre response in a virus-induced murine model of sialadenitis . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY . vol. 36 , S244 - S244 .

Bottini A, Wu DJ, Ai R, LeRoux M, Bartok B, Bombardieri M, Zhang V, Doody KM et al. ( 2018 ) . Non-Receptor Protein Tyrosine Phosphatase 14 (PTPN14) Promotes YAP-Dependent Tgfbeta Signaling in RA FLS . ARTHRITIS & RHEUMATOLOGY . vol. 70 ,

Papas AS, Farag AM, Fisher B, Zeher M, Ng W-F, Bombardieri M, Posch M, Daikeler T et al. ( 2018 ) . Patient and investigator reported outcomes suggest improvements upon treatment with the novel anti-CD40 monoclonal antibody CFZ533 in patients with primary Sjogren's syndrome: a phase iia double-blind, placebo-controlled randomized trial . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY . vol. 36 , S251 - S252 .

Colafrancesco S, Priori R, Pipi E, Campos J, Nayar S, Cerbelli B, Arienzo F, Giordano C et al. ( 2018 ) . Role of CXCL13 and CXCL12 in Sjogren's syndrome: association with histological, clinical and laboratory features . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY . vol. 36 , S296 - S297 .

Retamozo S, Hernandez-Molina G, Valim V, Moca Trevisani VF, Pasoto SG, Acar-Denizli N, Zeher M, Sivils K et al. ( 2018 ) . SYSTEMIC SJOGREN PRESENTING WITHOUT SICCA SYNDROME: CHARACTERIZATION OF 240 PATIENTS ACCORDING TO THE NEW 2017 ACR/EULAR CLASSIFICATION CRITERIA . JCR-JOURNAL OF CLINICAL RHEUMATOLOGY . vol. 24 , S29 - S30 .

Corsiero E, Jagemann L, Pontarini E, Fossati-Jimack L, Pitzalis C, Bombardieri M ( 2018 ) . Single-cell VH and VL Ig gene analysis reveal clonal relationship between IgM plus neoplastic B cells and plasmablasts in SS patients with parotid MALT lymphoma . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY . vol. 36 , S249 - S249 .

Retamozo S, Acar-Denizli N, Zeher M, Sivils K, Mandl T, Seror R, Li X, Baldini C et al. ( 2018 ) . Systemic Sjogren presenting without sicca syndrome: characterization of 240 patients according to the new 2017 ACR/EULAR Classification Criteria . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY . vol. 36 , S268 - S269 .

Pontarini E, Murray-Brown W, Croia C, Corsiero E, Fossati-Jimack L, Astorri E, Lucchesi D, Lepse N et al. ( 2018 ) . T follicular-helper cells (TFH) enrichment and follicular T regulatory cells (TFR) exclusion from ectopic germinal centers in salivary glands of Sjogren's Syndrome patients . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY . vol. 36 , S291 - S291 .

Fisher B, Zeher M, Ng W-F, Bombardieri M, Posch M, Papas AS, Farag AM, Daikeler T et al. ( 2018 ) . The novel anti-CD40 monoclonal antibody CFZ533 modulates biomarkers relevant to disease and CD40 pathways in patients with primary Sjogren's syndrome . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY . vol. 36 , S245 - S246 .

Fisher BA, Everett CC, Rout J, O'Dwyer JL, Emery P, Pitzalis C, Ng W-F, Carr A et al. ( 2017 ) . Effect of rituximab on a salivary gland ultrasound score in primary Sjögren’s syndrome: results of the TRACTISS randomised double-blind multicentre substudy . Annals of the Rheumatic Diseases vol. 77 , ( 3 )

Bezzina OM, Gallagher P, Mitchell S, Bowman SJ, Griffiths B, Hindmarsh V, Hargreaves B, Price EJ et al. ( 2017 ) . Subjective and Objective Measures of Dryness Symptoms in Primary Sjögren's Syndrome: Capturing the Discrepancy . Arthritis Care Res (Hoboken) vol. 69 , ( 11 ) 1714 - 1723 .

Valesini G, Colasanti T, Alessandri C, Bombardieri M, Conti F, Sorice M ( 2017 ) . Citrullination and Autophagy . Protein Deimination in Human Health and Disease , Springer Nature

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Price EJ, Rauz S, Tappuni AR, Sutcliffe N, Hackett KL, Barone F, Granata G, Ng W-F et al. ( 2017 ) . The British Society for Rheumatology guideline for the management of adults with primary Sjögren's Syndrome . Rheumatology (Oxford) vol. 56 , ( 10 ) 1828 - 1828 .

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Fisher B, Everett C, Rout J, O'Dywer J, Emery P, Pitzalis C, Ng W-F, Carr A et al. ( 2017 ) . AB0444 Effect of rituximab on a salivary gland ultrasound score in primary sjÖgren's syndrome: results of the tractiss multicentre randomised trial sub-study . Annals of the Rheumatic Diseases . Conference: Abstracts Accepted for Publication vol. 76 ,

Pucino V, Smith J, Cucchi D, Blighe K, Bombardieri M, Pitzalis C, Mauro C ( 2017 ) . FRI0076 LACTATE/SLC5A12-induced metabolic signalling network: a new target in rheumatoid arthritis . Annals of the Rheumatic Diseases . Conference: Poster Presentations vol. 76 ,

Lliso-Ribera G, Humby F, Kelly S, Bombardieri M, Lewis M, Hands R, Rocher V, Bene F et al. ( 2017 ) . FRI0088 Synovial pathobiology correlates with diagnostic subgroups in early inflammatory arthritis: results from the pathobiology of early arthritis cohort (PEAC) . Annals of the Rheumatic Diseases . Conference: Poster Presentations vol. 76 ,

Corsiero E, Jagemann L, Prediletto E, Pitzalis C, Bombardieri M ( 2017 ) . OP0175 Characterization of novel stromal-derived autoantigens recognized by ra synovial monoclonal antibodies . Annals of the Rheumatic Diseases . Conference: Oral Presentations vol. 76 ,

Pontarini E, Murray-Brown W, Croia C, Astorri E, Lucchesi D, Lepse N, Sutcliffe N, Tappuni A et al. ( 2017 ) . OP0300 Enrichment of T follicular-helper cells (TFH) and exclusion of t follicular-regulatory cells (TFR) from ectoPIC germinal centers in salivary glands of sjogren's syndrome patients . Annals of the Rheumatic Diseases . Conference: Oral Presentations vol. 76 ,

Brito-Zerόn P, Acar-Denizli N, Zeher M, Rasmussen A, Seror R, Mandl T, Li X, Baldini C et al. ( 2017 ) . SAT0302 Analysis of 9302 patients from the big data international primary sjÖgren syndrome cohort: clinical presentation at diagnosis of european vs non-european patients . Annals of the Rheumatic Diseases . Conference: Poster Presentations vol. 76 ,

Lliso-Ribera G, Humby F, Kelly S, Bombardieri M, Lewis M, Hands R, Rocher V, Bene F et al. ( 2017 ) . THU0100 In early inflammatory arthritis a lymphoid pathotype signficantly associates with requirement for biologic therapy at 12 months follow up: results from the pathobiology of early arthritis cohort (PEAC) . Annals of the Rheumatic Diseases . Conference: Poster Presentations vol. 76 ,

Brito-Zerόn P, Acar-Denizli N, Zeher M, Rasmussen A, Li X, Baldini C, Gottenberg J-E, Danda D et al. ( 2017 ) . THU0284 Predicting survival in 6240 patients with primary sjÖgren' syndrome (big data sjÖgren project) . Annals of the Rheumatic Diseases . Conference: Poster Presentations vol. 76 ,

Brito-Zerόn P, Acar-Denizli N, Zeher M, Rasmussen A, Li X, Baldini C, Gottenberg J-E, Danda D et al. ( 2017 ) . THU0681 Baseline ESSDAI/DAS scores in 8061 patients with primary sjÖgren syndrome: characterization of systemic disease . Annals of the Rheumatic Diseases . Conference: Poster Presentations vol. 76 ,

Bowman SJ, Everett CC, O'Dwyer JL, Emery P, Pitzalis C, Ng W-F, Pease CT, Price EJ et al. ( 2017 ) . Randomized Controlled Trial of Rituximab and cost-effectiveness analysis in treating fatigue and oral dryness in primary Sjogren's Syndrome . Arthritis Rheumatol

Corsiero E, Jagemann L, Prediletto E, Pitzalis C, Bombardieri M ( 2017 ) . 08.34 Ra synovial recombinant monoclonal antibodies from single b cells target citrullinated calreticulin . Annals of the Rheumatic Diseases . Conference: Autoimmune inflammation vol. 76 ,

Lucchesi D, Pontarini E, Pitzalis C, Mavilio D, Bombardieri M ( 2017 ) . MYELOID CELLS DRIVE EARLY INFLAMMATION AND ORCHESTRATE SALIVARY GLANDS TERTIARY LYMPHOID STRUCTURES FORMATION IN A MODEL OF INDUCIBLE SIALADENITIS . ANNALS OF THE RHEUMATIC DISEASES . Conference: EWRR ( Athens ) from: 02/03/2017 to: 04/03/2017 , vol. 76 , A4 - A4 .

Bombardieri M, Lewis M, Pitzalis C ( 2017 ) . Ectopic lymphoid neogenesis in rheumatic autoimmune diseases . Nature Reviews Rheumatology

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Fisher B, Everett C, Rout J, O'Dwyer J, Emery P, Pitzalis C, Ng W-F, Carr A et al. ( 2017 ) . Effect of Rituximab on a Salivary Gland Ultrasound Score in Primary Sjgren's Syndrome: Results of Multicentre Double-Blind Randomised Controlled Trial Sub-Study . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,

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Davies K, Mirza K, Tarn J, Regan M, Vadivelu S, Clunie G, Andrews J, Price E et al. ( 2017 ) . Longitudinal Analysis of Different Therapeutic Strategies in Patients with Primary Sjogren's Syndrome . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,

Pontarini E, Brown WM, Croia C, Corsiero E, Lucchesi D, Astorri E, Sutcliffe N, Tappuni A et al. ( 2017 ) . T Follicular- Helper CELLS (TFH) Enrichment and T Follicular-Regulatory CELLS (TFR) Exclusion from Ectopic Germinal Centers in Salivary Glands of Sjogren's Syndrome Patients . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,

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Fisher BA, Jonsson R, Daniels T, Bombardieri M, Brown RM, Morgan P, Bombardieri S, Ng W-F et al. ( 2016 ) . Standardisation of labial salivary gland histopathology in clinical trials in primary Sjögren's syndrome . Annals of the Rheumatic Diseases vol. 76 , ( 7 )

Brito-Zerón P, Acar-Denizli N, Zeher M, Rasmussen A, Seror R, Theander E, Li X, Baldini C et al. ( 2016 ) . Influence of geolocation and ethnicity on the phenotypic expression of primary Sjögren's syndrome at diagnosis in 8310 patients: a cross-sectional study from the Big Data Sjögren Project Consortium . Annals of the Rheumatic Diseases vol. 76 , ( 6 )

Corsiero E, Pratesi F, Prediletto E, Bombardieri M, Migliorini P ( 2016 ) . NETosis as Source of Autoantigens in Rheumatoid Arthritis . Front Immunol vol. 7 , 485 - 485 .

Corsiero E, Nerviani A, Bombardieri M, Pitzalis C ( 2016 ) . Ectopic Lymphoid Structures: Powerhouse of Autoimmunity . Front Immunol vol. 7 , Article 00430 , 430 - 430 .

Conti F, Spinelli FR, Truglia S, Miranda F, Alessandri C, Ceccarelli F, Bombardieri M, Giannakakis K et al. ( 2016 ) . Kidney Expression of Toll Like Receptors in Lupus Nephritis: Quantification and Clinicopathological Correlations . Mediators Inflamm vol. 2016 , 7697592 - 7697592 .

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Nerviani A, DiCicco M, Humby F, Kelly S, Zou L, Lewis M, Hands R, Rocher V et al. ( 2016 ) . FRI0157 A Baseline Prediction Model for Response To Certolizumab-Pegol: Role of Synovial Histopathology . Annals of the Rheumatic Diseases . vol. 75 ,

Gupta V, Peters J, Bombardieri M, Radunovic A, Sutcliffe N ( 2016 ) . FRI0352 Small Fibre Neuropathy and Ganglionopathy in Primary Sjogren's Syndrome (PSS) . Annals of the Rheumatic Diseases . vol. 75 ,

Humby F, Dicicco M, Kelly S, Bombardieri M, Hands R, Rocher V, Zou L, Myles L et al. ( 2016 ) . OP0240 Synovial Lymphocytic Aggregates Associate with Highly Active RA and Predict Erosive Disease Progression at 12 Months: Results from The Pathobiology of Early Arthritis Cohort . Annals of the Rheumatic Diseases vol. 75 , ( Suppl 2 )

Mahto A, Humby F, Gregoriadou S, Ng N, Blighe K, Zou L, Lewis M, Bombardieri M et al. ( 2016 ) . OP0263 Synovial B-Cell Gene Signature Predicts Response To Rituximab Therapy . Annals of the Rheumatic Diseases . vol. 75 ,

Brito-Zerόn P, Acar-Denizli N, Zeher M, Rasmussen A, Seror R, Mandl T, Li X, Baldini C et al. ( 2016 ) . SAT0287 Ethnic Differences Strongly Influence The Phenotypic Expression of Primary Sjögren: Study of 7887 Patients from 20 Countries on 5 Continents (EULAR-SS Task Force Big Data Sjögren Project) . Annals of the Rheumatic Diseases . vol. 75 ,

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Weller ML, Gardener MR, Bogus ZC, Smith MA, Astorri E, Michael DG, Michael DA, Zheng C et al. ( 2016 ) . Hepatitis Delta Virus Detected in Salivary Glands of Sjögren’s Syndrome Patients and Recapitulates a Sjögren’s Syndrome-Like Phenotype in Vivo . Pathogens and Immunity vol. 1 , ( 1 ) 12 - 40 .

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Lepse N, Nerviani A, Pitzalis C, Bombardieri M ( 2016 ) . 069 T Follicular Helper–Like Cells in the Rheumatoid Arthritis Synovium are Selectively Associated with Interleukin-21 Production and Ectopic Lymphoid Structures . Rheumatology vol. 55 , ( suppl_1 ) i89 - i89 .

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DiCicco M, Humby F, Kelly S, Bombardieri M, Rebecca H, Rocher V, Zou L, Myles L et al. ( 2016 ) . O49 Synovial Lymphocytic Aggregates Associate with Highly Active RA and Predict Erosive Disease Progression at 12 Months: Results from the Pathobiology of Early Arthritis Cohort . Rheumatology vol. 55 , ( suppl_1 ) i59 - i59 .

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Corsiero E, Carlotti E, Prediletto E, Jagemann L, Pitzalis C, Bombardieri M ( 2016 ) . A2.04 The role of somatic hypermutation and n-glycosylation in the anti-nets immunoreactivity of ra synovial monoclonal antibodies . Annals of the Rheumatic Diseases . vol. 75 ,

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Astorri E, Lucchesi D, Pitzalis C, Bombardieri M ( 2016 ) . Chapter 7 Spontaneous and Inducible Animal Models of Sjögren’s Syndrome . Sjogren's Syndrome , Elsevier

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Jones GW, Bombardieri M, Greenhill CJ, McLeod L, Nerviani A, Rocher-Ros V, Cardus A, Williams AS et al. ( 2016 ) . Interleukin-27 inhibits synovial lymphoid neogenesis in inflammatory arthritis . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 46 , 1024 - 1024 .

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DiCicco M, Humby F, Kelly S, Bombardieri M, Rebecca H, Rocher V, Zou L, Myles L et al. ( 2016 ) . SYNOVIAL LYMPHOCYTIC AGGREGATES ASSOCIATE WITH HIGHLY ACTIVE RA AND PREDICT EROSIVE DISEASE PROGRESSION AT 12 MONTHS: RESULTS FROM THE PATHOBIOLOGY OF EARLY ARTHRITIS COHORT . RHEUMATOLOGY . vol. 55 , 59 - 59 .

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Lepse N, Nerviani A, Pitzalis C, Bombardieri M ( 2016 ) . T FOLLICULAR HELPER-LIKE CELLS IN THE RHEUMATOID ARTHRITIS SYNOVIUM ARE SELECTIVELY ASSOCIATED WITH INTERLEUKIN-21 PRODUCTION AND ECTOPIC LYMPHOID STRUCTURES . RHEUMATOLOGY . vol. 55 , 89 - 89 .

Corsiero E, Carlotti E, Prediletto E, Jagemann L, Pitzalis C, Bombardieri M ( 2016 ) . The role of somatic hypermutation and N-glycosylation in the anti-NET immunoreactivity of RA synovial monoclonal antibodies . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 46 , 116 - 117 .

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Astorri E, Sutcliffe N, Richards PS, Suchak K, Pitzalis C, Bombardieri M, Tappuni AR ( 2015 ) . Ultrasound of the salivary glands is a strong predictor of labial gland biopsy histopathology in patients with sicca symptoms . Journal of Oral Pathology and Medicine vol. 45 , ( 6 ) 450 - 454 .

Corsiero E, Bombardieri M, Carlotti E, Pratesi F, Robinson W, Migliorini P, Pitzalis C ( 2015 ) . Single cell cloning and recombinant monoclonal antibodies generation from RA synovial B cells reveal frequent targeting of citrullinated histones of NETs . Annals of the Rheumatic Diseases1866 - 1875 .

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Haas R, Smith J, Rocher-Ros V, Nadkarni S, Montero-Melendez T, D’Acquisto F, Bland EJ, Bombardieri M et al. ( 2015 ) . Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions . PLOS Biology vol. 13 , ( 7 )

Pontarini E, Lucchesi D, Mavilio D, Bombardieri M ( 2015 ) . AB0169 Recruitment and Activation of NK Cells in the Salivary Glands Regulates Early Viral Control but is Dependable for Autoimmunity and Focal Lymphocytic Sialoadenitis in an Inducible Murine Model of Sjogren-Like Disease . Annals of the Rheumatic Diseases . vol. 74 ,

Astorri E, Croia C, Picarelli G, Sutcliffe N, Tappuni A, Bombardieri M, Priori R ( 2015 ) . AB0565 Routine Investigations for Circulating Igg4 and/or Igg4+ Salivary Gland Histopathology Fail to Reveal Undiagnosed Cases of Igg4 Related Disease in Sicca Patients not Fulfilling the Diagnosis of Sjogren's Syndrome . Annals of the Rheumatic Diseases . vol. 74 ,

Corsiero E, Carlotti E, Pitzalis C, Bombardieri M ( 2015 ) . FRI0007 The Importance of Somatic Hypermutation for the Immunoreactivity Towards Neutrophil Extracellular Traps (NETS)-Citrullinated Autoantigens of Ra Synovial Monoclonal Antibodies . Annals of the Rheumatic Diseases . vol. 74 ,

Carlotti E, Floyd J, Murray-Brown W, Barnes M, Mehr R, Bombardieri M, Pitzalis C ( 2015 ) . FRI0008 Longitudinal Analysis of the IGH-VH Gene by High-Throughput Sequencing in Early Rheumatoid Arthritis Paired Biopsies and its Association with Response to Dmards . Annals of the Rheumatic Diseases . vol. 74 ,

Murray-Brown W, Carlotti E, Floyd J, Sutcliffe N, Tappuni A, Vartoukian S, Fortune F, Mehr R et al. ( 2015 ) . FRI0020 Next-Generation Sequencing Demonstrates Dynamic Recirculation of B Cell Clones in Ectopic Lymphoid Structures of Sjögren's Syndrome . Annals of the Rheumatic Diseases . vol. 74 ,

Decourcey J, Nerviani A, Melgar S, Bulfone-Paus S, Loscher CE, Bombardieri M, Pitzalis C ( 2015 ) . OP0117 Snare Regulation of TH17 Cells and Ectopic Lymphoid Structure (ELS) Formation in Rheumatoid Arthritis . Annals of the Rheumatic Diseases . vol. 74 ,

Nayar S, Campos J, Cloake T, Bowman S, Bombardieri M, Pitzalis C, Luther S, Buckley C et al. ( 2015 ) . SAT0005 IL22 Regulates Autoantibody Production by Inducing Lymphoid Chemokine Expression in Tertiary Lymphoid Organs . Annals of the Rheumatic Diseases . vol. 74 ,

Nerviani A, Humby F, Kelly S, Bombardieri M, Pitzalis C ( 2015 ) . THU0033 A Functional Inhibitory Role for the GAS6/MERTK Axis in Modulating Synovial Inflammation in Rheumatoid Arthritis . Annals of the Rheumatic Diseases . vol. 74 ,

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Di Cicco M, Humby F, Kelly S, Ng N, Mahto A, Lazarou I, Hands RE, Rocher V et al. ( 2015 ) . Young Investigator AwadrI32. Synovial Pathotype Predicts Response to TNF-Alpha Inhibitors In Patients With Rheumatoid Arthritis . Rheumatology vol. 54 , ( suppl_1 ) i6 - i6 .

Lendrem D, Mitchell S, McMeekin P, Gompels L, Hackett K, Bowman S, Price E, Pease CT et al. ( 2015 ) . Do the EULAR Sjögren's syndrome outcome measures correlate with health status in primary Sjögren's syndrome? . Rheumatology (Oxford) vol. 54 , ( 4 ) 655 - 659 .

Kelly S, Bombardieri M, Humby F, Ng N, Marrelli A, Riahi S, DiCicco M, Mahto A et al. ( 2015 ) . Angiogenic gene expression and vascular density are reflected in ultrasonographic features of synovitis in early Rheumatoid Arthritis: an observational study . Arthritis Res Ther vol. 17 , ( 1 )

Kelly S, Bombardieri M, Humby F, Ng N, Marrelli A, Riahi S, DiCicco M, Mahto A et al. ( 2015 ) . Angiogenic gene expression and vascular density are reflected in ultrasonographic features of synovitis in early rheumatoid arthritis: an observational study . Arthritis Research & Therapy vol. 17 , ( 1 )

Kelly S, Humby F, Filer A, Ng N, Di Cicco M, Hands RE, Rocher V, Bombardieri M et al. ( 2015 ) . Ultrasound-guided synovial biopsy: a safe, well-tolerated and reliable technique for obtaining high-quality synovial tissue from both large and small joints in early arthritis patients . Ann Rheum Dis vol. 74 , ( 3 ) 611 - 617 .

Brito-Zeron P, Retamozo S, Zeher M, Rasmussen A, Theander E, Gottenberg J, Baldini C, Quartuccio L et al. ( 2015 ) . Big Data International Primary Sjogren Syndrome Registry: Baseline Characterization and Diagnostic Approach in 6047 Patients Fulfilling the 2002 AE Criteria . ARTHRITIS & RHEUMATOLOGY vol. 67 ,

Weller M, Gardner M, Bogus Z, Smith M, Astorri E, Michael D, Zheng C, Burbelo P et al. ( 2015 ) . Detection of a Unique Viral Infection in Salivary Glands of Sjogren's Syndrome Patients and Viral-Mediated Recapitulation of Disease in Vivo . ARTHRITIS & RHEUMATOLOGY vol. 67 ,

Weller ML, Gardener MR, Bogus ZC, Smith MA, Astorri E, Michael DG, Michael DA, Zheng C et al. ( 2015 ) . Hepatitis Delta Virus Detected in Salivary Glands of Sjogren's Syndrome Patients and Induces a Sjogren's Syndrome Phenotype in vivo . SCANDINAVIAN JOURNAL OF IMMUNOLOGY . vol. 81 , 427 - 427 .

Nayar S, Campos J, Cloake T, Bowman S, Bombardieri M, Pitzalis C, Luther S, Buckley C et al. ( 2015 ) . IL22 Regulates Autoantibody Production by Inducing Lymphoid Chemokine Expression in Tertiary Lymphoid Organs . SCANDINAVIAN JOURNAL OF IMMUNOLOGY . vol. 81 , 425 - 425 .

Murray-Brown W, Carlotti E, Floyd J, Sutcliffe N, Tappuni A, Vartoukian S, Fortune F, Mehr R et al. ( 2015 ) . Next-Generation Sequencing Demonstrates Dynamic Recirculation of B Cell Clones in Ectopic Lymphoid Structures of Sjogren's Syndrome . SCANDINAVIAN JOURNAL OF IMMUNOLOGY . vol. 81 , 401 - 402 .

Bowman S, Everett C, Bombardieri M, Busch R, Emery P, Hall F, Pease CT, Pitzalis C et al. ( 2015 ) . Preliminary Results of a Double-Blind Randomised Trial of Rituximab Anti-B-Cell Therapy in Patients with Primary Sjogrens Syndrome . ARTHRITIS & RHEUMATOLOGY vol. 67 ,

Pontarini E, Lucchesi D, Mavilio D, Bombardieri M ( 2015 ) . Recruitment and Activation of NK Cells in the Salivary Glands Regulates Early Viral Control but is Dependable for Autoimmunity and Focal Lymphocytic Sialoadenitis in an Inducible Murine Model of Sjogren-Like Disease . SCANDINAVIAN JOURNAL OF IMMUNOLOGY . vol. 81 , 426 - 426 .

Astorri E, Croia C, Picarelli G, Sutcliffe N, Tappuni A, Bombardieri M, Priori R ( 2015 ) . Routine Investigations for Circulating IgG4 and/or IgG4+Salivary Gland Histopathology Fail to Reveal Undiagnosed Cases of IgG4 Related Disease in Sicca Patients not Fulfilling the Diagnosis of Sjogren's Syndrome . SCANDINAVIAN JOURNAL OF IMMUNOLOGY . vol. 81 , 341 - 341 .

Di Cicco M, Humby F, Kelly S, Ng N, Mahto A, Lazarou I, Hands RE, Rocher V et al. ( 2015 ) . SYNOVIAL PATHOTYPE PREDICTS RESPONSE TO TNF-ALPHA INHIBITORS IN PATIENTS WITH RHEUMATOID ARTHRITIS . RHEUMATOLOGY . vol. 54 , 6 - 6 .

DiCicco M, Humby F, Kelly S, Hands R, Ng N, Mahto A, Lazarou I, Rocher V et al. ( 2015 ) . Synovial Lymphocytic Aggregates Associate with Highly Active RA and Predict Erosive Disease at 12 Months: Results from the Pathobiology of Early Arthritis Cohort . ARTHRITIS & RHEUMATOLOGY vol. 67 ,

Corsiero E, Carlotti E, Pitzalis C, Bombardieri M ( 2015 ) . The Importance of Somatic Hypermutation for the Immunoreactivity Towards Neutrophil Extracellular Traps (NETs)-Citrullinated Autoantigens of RA Synovial Monoclonal Antibodies . ARTHRITIS & RHEUMATOLOGY vol. 67 ,

Astorri E, Nerviani A, Bombardieri M, Pitzalis C ( 2015 ) . Towards a stratified targeted approach with biologic treatments in rheumatoid arthritis: role of synovial pathobiology . Current Pharmaceutical Design vol. 21 , ( 17 ) 2216 - 2224 .

Fisher B, Jonsson R, Daniels T, Bombardieri M, Morgan P, Brown R, Bowman S, Barone F ( 2015 ) . Towards the Standardisation of Salivary Gland Histopathology for Use in the Diagnosis of Primary Sjogren's Syndrome and in Clinical Trials. Report of a Preliminary Workshop . SCANDINAVIAN JOURNAL OF IMMUNOLOGY . vol. 81 , 333 - 334 .

Corsiero E, Sutcliffe N, Pitzalis C, Bombardieri M ( 2014 ) . Accumulation of Self-Reactive Naïve and Memory B Cell Reveals Sequential Defects in B Cell Tolerance Checkpoints in Sjögren’s Syndrome . PLOS ONE vol. 9 , ( 12 )

VARTOUKIAN SR, Tilakaratne W, Seoudi N, Bombardieri M, Bergmeier L, Tappuni A, Fortune F ( 2014 ) . Dysregulation of the SOCS3-STAT3 pathway in the aetio-pathogenesis of Sjögren’s syndrome . Clinical and Experimental Immunology vol. 177 , ( 3 ) 618 - 629 .

Croia C, Astorri E, Murray-Brown W, Willis A, Brokstad KA, Sutcliffe N, Piper K, Jonsson R et al. ( 2014 ) . Implication of Epstein-Barr virus infection in disease-specific autoreactive B cell activation in ectopic lymphoid structures of Sjögren's syndrome . Arthritis Rheumatol vol. 66 , ( 9 ) 2545 - 2557 .

Corsiero E, Pitzalis C, Bombardieri M ( 2014 ) . Peripheral and synovial mechanisms of humoral autoimmunity in rheumatoid arthritis . Drug Discov Today vol. 19 , ( 8 ) 1161 - 1165 .

Pitzalis C, Jones GW, Bombardieri M, Jones SA ( 2014 ) . Ectopic lymphoid-like structures in infection, cancer and autoimmunity . Nat Rev Immunol vol. 14 , ( 7 ) 447 - 462 .

Lendrem D, Mitchell S, McMeekin P, Bowman S, Price E, T Pease C, Emery P, Andrews J et al. ( 2014 ) . Health-related utility values of patients with primary Sjögren's syndrome and its predictors . Annals of the Rheumatic Diseases vol. 73 , ( 7 ) 1362 - 1368 .

Di Cicco M, Humby F, Kelly S, Ng N, Mahto A, Hands R, Rocher V, Bombardieri M et al. ( 2014 ) . AB0132 Presence of Synovial Lymphocyte Aggregates Correlates with A More Severe Clinical Phenotype in Patients with Early Inflammatory Arthritis . Annals of the Rheumatic Diseases . vol. 73 ,

Di Cicco M, Humby FC, Kelly S, Ng N, Mahto A, Hands R, Rocher V, Zou L et al. ( 2014 ) . FRI0020 Presence of Synovial Lymphocyte Aggregates Predicts Clinical Response to DMARD Therapy in Patients with Early Rheumatoid Arthritis . Annals of the Rheumatic Diseases . vol. 73 ,

Ng N, Kelly S, Humby F, DiCicco M, Rocher V, Hands R, Bombardieri M, Pitzalis C ( 2014 ) . OP0054 Ultrasound Synovitis Reflects Synovial Inflammation at A Histopathological Level . Annals of the Rheumatic Diseases . vol. 73 ,

Corsiero E, Carlotti E, Pratesi F, Wardemann H, Robinson W, Migliorini P, Pitzalis C, Bombardieri M ( 2014 ) . OP0266 Monoclonal Antibodies Derived from Single CD19+ Synovial B Cells of RA Patients with Tertiary Lymphoid Structures Display Preferential Immunoreactivity towards Citrullinated Proteins of Nets . Annals of the Rheumatic Diseases . vol. 73 ,

Di Cicco M, Kelly S, Humby F, Ng N, Nerviani A, Rocher V, Hands R, Bombardieri M et al. ( 2014 ) . SAT0048 Synovial Lymphocytic Aggregates Predict Clinical Response to Certolizumab Pegol in Rheumatoid Arthritis (Clinical and Pathological Response to Certolizumab-Pegol (Clip-Cert) Study) . Annals of the Rheumatic Diseases . vol. 73 ,

Bombardieri M ( 2014 ) . SP0133 Raise for Impact: Epstein-Barr Virus in Rheumatic Patients . Annals of the Rheumatic Diseases . vol. 73 ,

Astorri E, Tappuni A, Sutcliffe N, Richards P, Pitzalis C, Bombardieri M ( 2014 ) . THU0008 A Negative High-Resolution Salivary Gland Ultrasound is Highly Predictive of Negative Labial Gland Biopsy in Patients with SICCA Symptoms . Annals of the Rheumatic Diseases . vol. 73 ,

Willis A, Cheng LH, Plowman PN, Jawad ASM, Bombardieri M, Tappuni AR ( 2014 ) . CR0391 Lacrimal lymphoma: an unusual presentation of Sjögren syndrome . Oral Surgery Oral Medicine Oral Pathology and Oral Radiology vol. 117 , ( 5 )

Juarez M, Toms TE, de Pablo P, Mitchell S, Bowman S, Nightingale P, Price EJ, Griffiths B et al. ( 2014 ) . Cardiovascular Risk Factors in Women With Primary Sjögren's Syndrome: United Kingdom Primary Sjögren's Syndrome Registry Results . Arthritis Care & Research vol. 66 , ( 5 ) 757 - 764 .

Di Cicco M, Kelly S, Humby F, Ng N, Hands RE, Rocher V, Nerviani A, Zou L et al. ( 2014 ) . 101. Synovial Ectopic Lymphoneogenesis Predicts Primary Clinical Response to Certolizumab Pegol in Patients with Rheumatoid Arthritis . Rheumatology vol. 53 , ( suppl_1 ) i95 - i95 .

Ng N, Humby F, Di Cicco M, Deidda S, Mahto A, Pyne D, Kidd B, Bombardieri M et al. ( 2014 ) . 124. Ultrasound-Guided Diagnostic Synovial Biopsies: An Audit of a Rheumatology-Led Service . Rheumatology vol. 53 , ( suppl_1 ) i105 - i106 .

Bombardieri M ( 2014 ) . I3. Future Therapeutic Approaches . Rheumatology vol. 53 , ( suppl_1 ) i1 - i1 .

Ng N, Kelly S, Humby F, Di Cicco M, Rocher V, Hands RE, Bombardieri M, Pitzalis C ( 2014 ) . O37. Ultrasound Measures of Synovitis Reflects Histological Synovial Inflammation in Early Arthritis Patients . Rheumatology vol. 53 , ( suppl_1 ) i45 - i45 .

Di Cicco M, Humby F, Kelly S, Ng N, Mahto A, Hands RE, Rocher V, Buckley C et al. ( 2014 ) . O44. Presence of Synovial Lymphocyte Aggregates Correlates with a More Severe Clinical Phenotype in Patients with Early Inflammatory Arthritis . Rheumatology vol. 53 , ( suppl_1 ) i48 - i48 .

Astorri E, Scrivo R, Bombardieri M, Picarelli G, Pecorella I, Porzia A, Valesini G, Priori R ( 2014 ) . CX3CL1 and CX3CR1 expression in tertiary lymphoid structures in salivary gland infiltrates: fractalkine contribution to lymphoid neogenesis in Sjogren's syndrome . Rheumatology (Oxford) vol. 53 , ( 4 ) 611 - 620 .

Lucchesi D, Pitzalis C, Bombardieri M ( 2014 ) . EBV and other viruses as triggers of tertiary lymphoid structures in primary Sjögren's syndrome . Expert Rev Clin Immunol vol. 10 , ( 4 ) 445 - 455 .

Corsiero E, Carlotti E, Wardemann H, Robinson W, Migliorini P, Pratesi F, Pitzalis C, Bombardieri M ( 2014 ) . A1.31 Monoclonal antibodies from CD19+ synovial B cells of RA patients with tertiary lymphoid structures display a strong immunoreactivity towards citrullinated histones from neutrophils NETs . Annals of the Rheumatic Diseases . vol. 73 ,

Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M ( 2014 ) . AB0022 Accumulation of circulating autoreactive naïve b cells reveal defects of early b cell tolerance checkpoints in patients with sjögren’s syndrome . Annals of the Rheumatic Diseases vol. 72 , ( Suppl 3 )

Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M ( 2014 ) . AB0044 Analysis of recombinant monoclonal antibodies from single B cells reveals early defects of B cell tolerance checkpoints in patients with sjÖgren’s syndrome . Annals of the Rheumatic Diseases vol. 71 , ( Suppl 3 )

Kam NW, Bombardieri M, Filter A, Buckley C, Pitzalis C ( 2014 ) . AB0099 Aberrant basal and TLR-stimulated expression of TSLP in rheumatoid synovial fibroblasts . Annals of the Rheumatic Diseases vol. 71 , ( Suppl 3 )

Croia C, Bombardieri M, Serafini B, Humby F, Migliorini P, Aloisi F, Pitzalis C ( 2014 ) . AB0155 Anti-VCA and EBNA1 antibodies are produced in the rheumatoid synovium in the presence of ectopic lymphoid structures and correlate with ACPA production . Annals of the Rheumatic Diseases vol. 71 , ( Suppl 3 )

Spinelli FR, Truglia S, Alessandri C, Bombardieri M, Ceccarelli F, Martinelli F, Miranda F, Conti V et al. ( 2014 ) . AB0200 High expression of toll like receptors 7 and interleukin 18 in lupus nephritis . Annals of the Rheumatic Diseases vol. 71 , ( Suppl 3 )

Murray-Brown W, Picarelli G, Vartoukian S, Sutcliffe N, Fortune F, Valesini G, Pitzalis C, Tappuni A et al. ( 2014 ) . AB0222 Monocyte-derived IL-32 expression correlates with the level of inflammation in salivary glands of sjÖgren’s syndrome . Annals of the Rheumatic Diseases vol. 71 , ( Suppl 3 )

Ng N, Humby F, Kelly S, Di Cicco M, Dadoun S, Bombardieri M, Hands R, Rocher V et al. ( 2014 ) . AB0247 Rheumatoid arthritis patient characteristics at different therapeutic timepoints . Annals of the Rheumatic Diseases vol. 72 , ( Suppl 3 )

Croia C, Serafini B, Tappuni A, Aloisi F, Sutcliffe N, Pitzalis C, Bombardieri M ( 2014 ) . FRI0259 Ectopic lymphoid structures support epstein-barr virus persistence and autoreactive plasma cell infection in sjogren’s syndrome salivary glands . Annals of the Rheumatic Diseases vol. 72 , ( Suppl 3 )

Ng W-F, Miller A, Bowman S, Price E, Kitas G, Pease C, Emery P, Lanyon P et al. ( 2014 ) . FRI0323 Level of physical activity in primary sjögren’s syndrome and its predictors . Annals of the Rheumatic Diseases vol. 72 , ( Suppl 3 )

Murray-Brown W, Croia C, Sutcliffe N, Tappuni A, Vartoukian S, Fortune F, Pitzalis C, Bombardieri M ( 2014 ) . OP0080 Lesional IL-21 Expression Correlates with Functional Germinal Center Formation and T Follicular Helper Cell Infiltration in the Salivary Glands of Sjögren’s Syndrome . Annals of the Rheumatic Diseases vol. 72 , ( Suppl 3 )

Astorri E, Scrivo R, Bombardieri M, Picarelli G, Pecorella I, Porzia A, Valesini G, Priori R ( 2014 ) . OP0082 Expression of Fractalkine in Sjögren’s Syndrome Patients: Cellular and Molecular Characterization of CX3CL1 and CX3CR1 in Sera and Salivary Glands . Annals of the Rheumatic Diseases vol. 72 , ( Suppl 3 )

Bombardieri M, Rocher V, Mittereder N, Carlesso G, Herbst R, Sleeman M, Pitzalis C ( 2014 ) . OP0303 Mavrilimumab Reduces Pro-Inflammatory Cytokines and CD68 Positive Macrophages in Synovial Explants from Rheumatoid Arthritis Subjects Engrafted Into SCID/Beige Mice . Annals of the Rheumatic Diseases vol. 72 , ( Suppl 3 )

Deidda S, Humby F, Kelly S, Di Cicco M, Ng N, Hands R, Bombardieri M, Pitzalis C ( 2014 ) . SAT0014 Synovial Sublining Macrophages: A Sensitive Biomarker for Response to Treatment in Early RA Patients . Annals of the Rheumatic Diseases vol. 72 , ( Suppl 3 )

Di Cicco M, Dadoun S, Humby F, Kelly S, Ng N, Hands RE, Buckley C, McInnes I et al. ( 2014 ) . THU0087 Synovial Ectopic Lymphoid-like Structures are Associated with Diagnosis of Rheumatoid Arthritis, Disease Activity and Antibody Status in Early Arthritis Patients . Annals of the Rheumatic Diseases vol. 72 , ( Suppl 3 )

Corsiero E, Bombardieri M, Carlotti E, Pratesi F, Robinson W, Migliorini P, Pitzalis C ( 2014 ) . Citrullinated histones from neutrophil extracellular traps (NETs) fuel ectopic germinal centre responses and ACPA production in rheumatoid joints . IMMUNOLOGY vol. 143 , 43 - 43 .

Di Cicco M, Humby F, Kelly S, Ng N, Mahto A, Hands RE, Rocher V, Buckley C et al. ( 2014 ) . PRESENCE OF SYNOVIAL LYMPHOCYTE AGGREGATES CORRELATES WITH A MORE SEVERE CLINICAL PHENOTYPE IN PATIENTS WITH EARLY INFLAMMATORY ARTHRITIS . RHEUMATOLOGY . vol. 53 , 48 - 48 .

Pontarini E, Lucchesi D, Bombardieri M, Mavilio D ( 2014 ) . Recruitment and activation of NK cells regulates early immune responses to viral infection in the salivary glands of an inducible murine model of Sjogren-like disease . IMMUNOLOGY vol. 143 , 93 - 93 .

Di Cicco M, Kelly S, Humby F, Ng N, Hands RE, Rocher V, Nerviani A, Zou L et al. ( 2014 ) . SYNOVIAL ECTOPIC LYMPHONEOGENESIS PREDICTS PRIMARY CLINICAL RESPONSE TO CERTOLIZUMAB PEGOL IN PATIENTS WITH RHEUMATOID ARTHRITIS . RHEUMATOLOGY . vol. 53 , 95 - 95 .

James K, Lendrem D, Mitchell S, Hindmarsh V, Bowman S, Price EJ, Pease CT, Emery P et al. ( 2014 ) . THE UK PRIMARY SJOGREN'S SYNDROME REGISTRY (UKPSSR): A VALUABLE RESOURCE FOR FUTURE SJOGREN'S SYNDROM RESEARCH . RHEUMATOLOGY . vol. 53 , 136 - 136 .

Brown S, Coy NN, Pitzalis C, Emery P, Pavitt S, Gray J, Hulme C, Hall F et al. ( 2014 ) . The TRACTISS Protocol: a randomised double blind placebo controlled clinical TRial of Anti-B-Cell Therapy In patients with primary Sjogren's Syndrome . BMC MUSCULOSKELETAL DISORDERS vol. 15 , Article ARTN 21 ,

Ng N, Kelly S, Humby F, Di Cicco M, Rocher V, Hands RE, Bombardieri M, Pitzalis C ( 2014 ) . ULTRASOUND MEASURES OF SYNOVITIS REFLECTS HISTOLOGICAL SYNOVIAL INFLAMMATION IN EARLY ARTHRITIS PATIENTS . RHEUMATOLOGY . vol. 53 , 45 - 45 .

Ng N, Humby F, Di Cicco M, Deidda S, Mahto A, Pyne D, Kidd B, Bombardieri M et al. ( 2014 ) . ULTRASOUND-GUIDED DIAGNOSTIC SYNOVIAL BIOPSIES: AN AUDIT OF A RHEUMATOLOGY-LED SERVICE . RHEUMATOLOGY . vol. 53 , 105 - 106 .

Lucchesi D, Bombardieri M ( 2013 ) . The role of viruses in autoreactive B cell activation within tertiary lymphoid structures in autoimmune diseases . J Leukoc Biol vol. 94 , ( 6 ) 1191 - 1199 .

Croia C, Serafini B, Bombardieri M, Kelly S, Humby F, Severa M, Rizzo F, Coccia EM et al. ( 2013 ) . Epstein-Barr virus persistence and infection of autoreactive plasma cells in synovial lymphoid structures in rheumatoid arthritis . Ann Rheum Dis vol. 72 , ( 9 ) 1559 - 1568 .

Strollo R, Ponchel F, Malmström V, Rizzo P, Bombardieri M, Wenham CY, Landy R, Perret D et al. ( 2013 ) . Autoantibodies to posttranslationally modified type II collagen as potential biomarkers for rheumatoid arthritis . Arthritis Rheum vol. 65 , ( 7 ) 1702 - 1712 .

Lendrem D, Mitchell S, McMeekin P, Bowman S, Price E, Pease CT, Emery P, Andrews J et al. ( 2013 ) . Health-related utility values of patients with primary Sjögren's syndrome and its predictors . Annals of the Rheumatic Diseases

Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M ( 2013 ) . ACCUMULATION OF CIRCULATING AUTOREACTIVE NAIVE B CELLS REVEALS DEFECTS OF EARLY B-CELL TOLERANCE CHECKPOINTS IN PATIENTS WITH SJOGREN'S SYNDROME . RHEUMATOLOGY . vol. 52 , 159 - 159 .

Ng N, Humby F, Bombardieri M, Kelly S, Di Cicco M, Dadoun S, Hands R, Rocher V et al. ( 2013 ) . CLINICAL, IMAGING AND HISTOLOGICAL CHARACTERISTICS OF PATIENTS WITH RHEUMATOID ARTHRITIS AT DIFFERENT STAGES OF DISEASE PROGRESSION . RHEUMATOLOGY . vol. 52 , 71 - 71 .

Kam NW, Filter A, Buckley C, Pitzalis C, Bombardieri M ( 2013 ) . MEMBRANE-BOUND AND SOLUBLE BAFF EXPRESSION BY HUMAN RHEUMATOID FIBROBLAST-LIKE SYNOVIOCYTES IN RESPONSE TO TLR STIMULATION . RHEUMATOLOGY . vol. 52 , 80 - 80 .

Di Cicco M, Humby F, Kelly S, Ng N, Hands R, Dadoun S, Buckley C, McInnes IB et al. ( 2013 ) . SYNOVIAL LYMPHOCYTE AGGREGATES IN EARLY INFLAMMATORY ARTHRITIS: CORRELATION WITH DIAGNOSIS, DISEASE ACTIVITY AND ANTIBODY STATUS . RHEUMATOLOGY . vol. 52 , 29 - 29 .

Tarn J, Natasari A, Mitchell S, Bowman S, Price E, Pease C, Emery P, Andrews J et al. ( 2013 ) . Soluble molecule profiling and network analysis of primary Sjögren's Syndrome patient serum . BMC Musculoskeletal Disorders vol. 14 , ( Suppl 1 )

Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M ( 2013 ) . ACCUMULATION OF CIRCULATING AUTOREACTIVE NAIVE B CELLS REVEAL DEFECTS OF EARLY B CELL TOLERANCE CHECKPOINTS IN PATIENTS WITH SJOGREN'S SYNDROME . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 792 - 792 .

Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M ( 2013 ) . Accumulation of Circulating Autoreactive Naive B Cells Reveal Defects of Early B Cell Tolerance Checkpoints in Patients with Sjogren's Syndrome . ANNALS OF THE RHEUMATIC DISEASES . vol. 72 , A30 - A31 .

Patel HB, Bombardieri M, Pitzalis C, Perretti M ( 2013 ) . Activation of Melanocortin Receptor 3 as a new strategy to control experimental and rheumatoid arthritis . FASEB JOURNAL . vol. 27 ,

Croia C, Serafini B, Tappuni A, Aloisi F, Sutcliffe N, Pitzalis C, Bombardieri M ( 2013 ) . ECTOPIC LYMPHOID STRUCTURES SUPPORT EPSTEIN-BARR VIRUS PERSISTENCE AND AUTOREACTIVE PLASMA CELL INFECTION IN SJOGREN'S SYNDROME SALIVARY GLANDS . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 462 - 462 .

Ng W-F, Lendrem D, Mitchell S, Bowman S, Price E, Pease C, Emery P, Andrews J et al. ( 2013 ) . EVALUATING HEALTH STATUS OF 620 PATIENTS WITH PRIMARY SJOGREN'S SYNDROME USING EQ-5D . ANNALS OF THE RHEUMATIC DISEASES vol. 71 , 466 - 466 .

Astorri E, Scrivo R, Bombardieri M, Picarelli G, Pecorella I, Porzia A, Valesini G, Priori R ( 2013 ) . EXPRESSION OF FRACTALKINE IN SJOGREN'S SYNDROME PATIENTS: CELLULAR AND MOLECULAR CHARACTERIZATION OF CX3CL1 AND CX3CR1 IN SERA AND SALIVARY GLANDS . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 78 - 78 .

Ng W-F, Mitchell S, Lendrem D, Bowman S, Price E, Pease C, Emery P, Andrews J et al. ( 2013 ) . HOW GOOD ARE THE EULAR SJOGREN'S SYNDROME DISEASE ACTIVITY INDEX (ESSDAI), AND EULAR SJOGREN'S SYNDROME PATIENTS REPORTED INDEX (ESSPRI) IN PREDICTING HEALTH STATUS IN PRIMARY SJOGREN'S SYNDROME? . ANNALS OF THE RHEUMATIC DISEASES vol. 71 , 553 - 554 .

Lucchesi D, Bombardieri M, Barone F, Nayar S, Proctor G, Buckley CD, Pitzalis C ( 2013 ) . INDUCIBLE TERTIARY LYMPHOID STRUCTURES AND AUTOIMMUNITY IN A NOVEL MODEL OF SIALOADENITIS IN WILD-TYPE MICE . ANNALS OF THE RHEUMATIC DISEASES . vol. 72 , A42 - A42 .

Jones GW, Bombardieri M, Greenhill CJ, McLeod L, Rocher V, Williams AS, Pitzalis C, Jenkins BJ et al. ( 2013 ) . Interleukin-27 as a novel antagonist of ectopic lymphoid-like structure development in early inflammatory arthritis . CYTOKINE . vol. 63 , 274 - 274 .

Murray-Brown W, Croia C, Sutcliffe N, Tappuni A, Vartoukian S, Fortune F, Pitzalis C, Bombardieri M ( 2013 ) . LESIONAL IL-21 EXPRESSION CORRELATES WITH FUNCTIONAL GERMINAL CENTER FORMATION AND T FOLLICULAR HELPER CELL INFILTRATION IN THE SALIVARY GLANDS OF SJOGREN'S SYNDROME . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 77 - 77 .

Ng W-F, Miller A, Bowman S, Price E, Kitas G, Pease C, Emery P, Lanyon P et al. ( 2013 ) . LEVEL OF PHYSICAL ACTIVITY IN PRIMARY SJOGREN'S SYNDROME AND ITS PREDICTORS . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 483 - 484 .

Murray-Brown W, Croia C, Sutcliffe N, Tappuni A, Pitzalis C, Bombardieri M ( 2013 ) . Lesional Intereukin-21 Expression Correlates With Functional Germinal Center Formation and T Follicular Helper Cell Infiltration In The Salivary Glands Of Sjogren's Syndrome . ARTHRITIS AND RHEUMATISM . vol. 65 , S634 - S634 .

Bombardieri M, Rocher V, Mittereder N, Carlesso G, Herbst R, Sleeman M, Pitzalis C ( 2013 ) . MAVRILIMUMAB REDUCES PRO-INFLAMMATORY CYTOKINES AND CD68 POSITIVE MACROPHAGES IN SYNOVIAL EXPLANTS FROM RHEUMATOID ARTHRITIS SUBJECTS ENGRAFTED INTO SCID/BEIGE MICE . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 156 - 157 .

Kam NW, Filer A, Buckley C, Bombardieri M, Pitzalis C ( 2013 ) . MEMBRANE-BOUND AND SOLUBLE BAFF EXPRESSION BY HUMAN RHEUMATOID FIBROBLAST-LIKE SYNOVIOCYTES IN RESPONSE TO TLR STIMULATION . ANNALS OF THE RHEUMATIC DISEASES . vol. 72 , A38 - A38 .

Ng N, Humby F, Kelly S, Di Cicco M, Dadoun S, Bombardieri M, Hands R, Rocher V et al. ( 2013 ) . RHEUMATOID ARTHRITIS PATIENT CHARACTERISTICS AT DIFFERENT THERAPEUTIC TIMEPOINTS . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 862 - 862 .

Corsiero E, Bombardieri M, Carlotti E, Wardemann H, Robinson WH, Pitzalis C ( 2013 ) . Recombinant Monoclonal Antibodies Derived From Single CD19+Synovial B Cells Of RA Patients With Tertiary Lymphoid Structures Display a Strong Immunoreactivity Towards Citrullinated Histones . ARTHRITIS AND RHEUMATISM . vol. 65 , S1127 - S1128 .

Tarn J, Mitchell S, Bowman S, Price E, Pease C, Sutcliffe N, Emery P, Andrews J et al. ( 2013 ) . SERUM CYTOKINE AND CHEMOKINE PROFILING IN PRIMARY SJOGREN'S SYNDROME . ANNALS OF THE RHEUMATIC DISEASES vol. 71 , 527 - 528 .

Di Cicco M, Dadoun S, Humby F, Kelly S, Ng N, Hands RE, Buckley C, McInnes I et al. ( 2013 ) . SYNOVIAL ECTOPIC LYMPHOID-LIKE STRUCTURES ARE ASSOCIATED WITH DIAGNOSIS OF RHEUMATOID ARTHRITIS, DISEASE ACTIVITY AND ANTIBODY STATUS IN EARLY ARTHRITIS PATIENTS . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 192 - 192 .

Croia C, Serafini B, Bombardieri M, Kelly S, Humby F, Severa M, Rizzo F, Coccia EM et al. ( 2013 ) . SYNOVIAL LYMPHOID STRUCTURES SUPPORT EPSTEIN-BARR VIRUS PERSISTENCE AND AUTOREACTIVE PLASMA CELL INFECTION IN RHEUMATOID ARTHRITIS . ANNALS OF THE RHEUMATIC DISEASES . vol. 72 , A43 - A44 .

Deidda S, Humby F, Kelly S, Di Cicco M, Ng N, Hands R, Bombardieri M, Pitzalis C ( 2013 ) . SYNOVIAL SUBLINING MACROPHAGES: A SENSITIVE BIOMARKER FOR RESPONSE TO TREATMENT IN EARLY RA PATIENTS . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 583 - 584 .

Kam YNW, Filer A, Buckley CD, Pitzalis C, Bombardieri M ( 2013 ) . Secretory Leukocyte Protease Inhibitor Released By Rheumatoid Synovial Fibroblasts Exerts a Negative Control Of BAFF-Dependent B Cell Activation In Vitro and In Vivo In The Collagen-Induced and Chimeric RA/SCID Arthritis Models . ARTHRITIS AND RHEUMATISM . vol. 65 , S1029 - S1029 .

Di Cicco M, Kelly S, Humby F, Ng N, Dadoun S, Hands R, Rocher V, Nerviani A et al. ( 2013 ) . Synovial Ectopic Lymphoneogenesis Predicts Clinical Response To Certolizumab Pegol In Patients With Rheumatoid Arthritis . ARTHRITIS AND RHEUMATISM . vol. 65 , S556 - S556 .

Wythe SE, DiCara D, Taher TEI, Finucane CM, Jones R, Bombardieri M, Man YKS, Nissim A et al. ( 2013 ) . Targeted delivery of cytokine therapy to rheumatoid tissue by a synovial targeting peptide . Ann Rheum Dis vol. 72 , ( 1 ) 129 - 135 .

Ciccia F, Rizzo A, Accardo-Palumbo A, Giardina A, Bombardieri M, Guggino G, Taverna S, Leo GD et al. ( 2012 ) . Increased expression of interleukin-32 in the inflamed ileum of ankylosing spondylitis patients . Rheumatology (Oxford) vol. 51 , ( 11 ) 1966 - 1972 .

Bombardieri M, Barone F, Lucchesi D, Nayar S, van den Berg WB, Proctor G, Buckley CD, Pitzalis C ( 2012 ) . Inducible tertiary lymphoid structures, autoimmunity, and exocrine dysfunction in a novel model of salivary gland inflammation in C57BL/6 mice . J Immunol vol. 189 , ( 7 ) 3767 - 3776 .

Bombardieri M, Pitzalis C ( 2012 ) . Ectopic lymphoid neogenesis and lymphoid chemokines in Sjogren's syndrome: at the interplay between chronic inflammation, autoimmunity and lymphomagenesis . Curr Pharm Biotechnol vol. 13 , ( 10 ) 1989 - 1996 .

Corsiero E, Bombardieri M, Manzo A, Bugatti S, Uguccioni M, Pitzalis C ( 2012 ) . Role of lymphoid chemokines in the development of functional ectopic lymphoid structures in rheumatic autoimmune diseases . Immunol Lett vol. 145 , ( 1-2 ) 62 - 67 .

Whitehead MA, Bombardieri M, Pitzalis C, Vanhaesebroeck B ( 2012 ) . Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter . Biochem J vol. 443 , ( 3 ) 857 - 867 .

Croia C, Bombardieri M, Francesca A, Serafini B, Humby F, Kelly S, Migliorini P, Pitzalis C ( 2012 ) . ANTI-VCA AND EBNA1 ANTIBODIES ARE PRODUCED IN THE RHEUMATOID SYNOVIUM IN THE PRESENCE OF ECTOPIC LYMPHOID STRUCTURES AND CORRELATE WITH ACPA PRODUCTION . RHEUMATOLOGY . vol. 51 , 43 - 43 .

Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M ( 2012 ) . Accumulation of circulating autoreactive naive B cells reveal defects of early B cell tolerance checkpoints in patients with Sjogren's syndrome . IMMUNOLOGY . vol. 137 , 327 - 327 .

Newton JL, Frith J, Powell D, Hackett K, Wilton K, Bowman S, Price E, Pease C et al. ( 2012 ) . Autonomic symptoms are common and are associated with overall symptom burden and disease activity in primary Sjogren's syndrome . ANNALS OF THE RHEUMATIC DISEASES vol. 71 , ( 12 ) 1973 - 1979 .

Nayar S, Cloake T, Bombardieri M, Pitzalis C, Buckley C, Barone F ( 2012 ) . ECTOPIC LYMPHONEOGENESIS IN A NOVEL MURINE MODEL OF SALIVARY GLANDS SIALOADENITIS IS CHARACTERIZED BY ASYNCHRONY IN THE LYMPHANGIOGENETIC AND ANGIOGENETIC PROGRAM . RHEUMATOLOGY . vol. 51 , 143 - 144 .

Lendrem D, Mitchell S, Bowman S, Price E, Pease CT, Emery P, Andrews J, Bombardieri M et al. ( 2012 ) . EVALUATING HEALTH STATUS OF 620 PATIENTS WITH PRIMARY SJOGREN'S SYNDROME USING EQ-5D . RHEUMATOLOGY . vol. 51 , 171 - 171 .

Lendrem D, Mitchell S, Bowman S, Price E, Pease CT, Emery P, Andrews J, Bombardieri M et al. ( 2012 ) . HOW GOOD ARE THE EULAR SJOGREN'S SYNDROME DISEASE ACTIVITY INDEX, AND EULAR SJOGREN'S SYNDROME PATIENTS REPORTED INDEX IN PREDICTING HEALTH STATUS IN PRIMARY SJOGREN'S SYNDROME? . RHEUMATOLOGY . vol. 51 , 176 - 176 .

Jones GW, Greenhill CJ, Williams AS, Nowell MA, Bombardieri M, Pitzalis C, Jenkins BJ, Jones SA ( 2012 ) . IL-27 control of ectopic lymphoid structures in inflammatory arthritis . IMMUNOLOGY . vol. 137 , 44 - 44 .

Lucchesi D, Bombardieri M, Barone F, Nayar S, Proctor G, Buckley CD, Pitzalis C ( 2012 ) . Inducible tertiary lymphoid structures formation in a novel model of sialoadenitis in wild-type mice is preceded by ectopic expression of lymphoid chemokines . IMMUNOLOGY . vol. 137 , 189 - 189 .

Murray-Brown W, Croia C, Sutcliffe N, Tappuni A, Vartoukian S, Fortune F, Pitzalis C, Bombardieri M ( 2012 ) . Lesional IL-21 expression correlates with functional germinal center formation and T follicular helper cell infiltration in the salivary glands of Sjogren's syndrome . IMMUNOLOGY . vol. 137 , 491 - 491 .

Murray-Brown W, Priori R, Tappuni T, Vartoukian S, Seoudi N, Picarelli G, Fortune F, Valesini G et al. ( 2012 ) . MONOCYTE-DERIVED IL-32 EXPRESSION CORRELATES WITH THE LEVEL OF INFLAMMATION IN SALIVARY GLANDS OF SJOGREN'S SYNDROME . RHEUMATOLOGY . vol. 51 , 176 - 176 .

Kam NW, Filer A, Buckley C, Bombardieri M, Pitzalis C ( 2012 ) . Membrane-bound and soluble BAFF expression by human rheumatoid fibroblast-like synoviocytes in response to TLR stimulation . IMMUNOLOGY . vol. 137 , 583 - 584 .

Vila J, Mitchell S, Bowman S, Price E, Pease CT, Emery P, Andrews J, Bombardieri M et al. ( 2012 ) . THE CLINICAL RELEVANCE OF ANTI-RO52 AND ANTI-RO60 IN PATIENTS IN THE UNITED KINGDOM PRIMARY SJOGREN'S SYNDROME REGISTRY (UKPSSR) . RHEUMATOLOGY . vol. 51 , 35 - 35 .

DiCicco M, Humby F, Kelly S, Hands R, Buckley C, McInnes I, Taylor P, Bombardieri M et al. ( 2012 ) . THE PATHOBIOLOGY OF EARLY ARTHRITIS COHORT: A PRELIMINARY ANALYSIS CORRELATING HISTOMORPHOLOGY AND DISEASE ACTIVITY . RHEUMATOLOGY . vol. 51 , 149 - 149 .

Kelly S, Bombardieri M, Humby F, Ng N, Di Cicco M, Hands R, Epis O, Filer A et al. ( 2012 ) . ULTRASOUND GUIDED SYNOVIAL BIOPSIES: SAFETY, TOLERABILITY, AND TISSUE QUALITY . RHEUMATOLOGY . vol. 51 , 68 - 68 .

Bombardieri M, Kam N-W, Brentano F, Choi K, Filer A, Kyburz D, McInnes IB, Gay S et al. ( 2011 ) . A BAFF/APRIL-dependent TLR3-stimulated pathway enhances the capacity of rheumatoid synovial fibroblasts to induce AID expression and Ig class-switching in B cells . Ann Rheum Dis vol. 70 , ( 10 ) 1857 - 1865 .

Scrivo R, Spadaro A, Riccieri V, Bombardieri M, Di Franco M, Celestino D, Valesini G ( 2011 ) . Soluble P-selectin levels in synovial fluid and serum from patients with psoriatic arthritis . Reumatismo vol. 57 , ( 4 ) 250 - 255 .

Marrelli A, Bombardieri M, Kelly S, Cipriani P, Giacomelli R, Pitzalis C ( 2011 ) . DIGITAL IMAGE ANALYSIS FOR THE EVALUATION OF BLOOD VESSEL DENSITY IN RHEUMATOID SYNOVIUM: CORRELATION WITH QUANTITATIVE REAL-TIME PCR EXPRESSION OF ENDOTHELIAL ANTIGEN AND ANGIOGENIC GROWTH FACTORS . RHEUMATOLOGY . vol. 50 , 75 - 75 .

Croia C, Serafini B, Bombardieri M, Kelly S, Coccia EM, Severa M, Francesca A, Pitzalis C ( 2011 ) . EBV INFECTION IN THE RHEUMATOID ARTHRITIS SYNOVIUM: RELATIONSHIP TO ECTOPIC LYMPHOID STRUCTURES AND CD8 T CELL ACTIVATION . RHEUMATOLOGY . vol. 50 , 75 - 75 .

Bombardieri M ( 2011 ) . HOW WILL B-CELL BASIC SCIENCE RESEARCH DRIVE TREATMENT IN SJOGREN'S SYNDROME? . RHEUMATOLOGY . vol. 50 , 12 - 13 .

Priori R, Barone F, Alessandri C, Colafrancesco S, McInnes IB, Pitzalis C, Valesini G, Bombardieri M ( 2011 ) . Markedly increased IL-18 liver expression in adult-onset Still's disease-related hepatitis . Rheumatology (Oxford) vol. 50 , ( 4 ) 776 - 780 .

Mahoney DJ, Swales C, Athanasou NA, Bombardieri M, Pitzalis C, Kliskey K, Sharif M, Day AJ et al. ( 2011 ) . TSG-6 Inhibits Osteoclast Activity via an Autocrine Mechanism and Is Functionally Synergistic With Osteoprotegerin . ARTHRITIS RHEUM-US vol. 63 , ( 4 ) 1034 - 1043 .

Rajak R, Amos N, Camilleri J, Charles PJ, Plant D, Chowdhury M, Worthington J, Venables P et al. ( 2011 ) . Rheumatoid arthritis - aetiopathogenesis and animal models . Rheumatology vol. 50 , ( suppl_3 ) iii74 - iii76 .

Astorri E, Bombardieri M, Gabba S, Peakman M, Pozzilli P, Pitzalis C ( 2011 ) . EVOLUTION OF ECTOPIC LYMPHOID NEOGENESIS AND IN SITU AUTOANTIBODIES PRODUCTION IN AUTOIMMUNE DIABETIC NOD MICE: CELLULAR AND MOLECULAR CHARACTERISATION OF TERTIARY LYMPHOID STRUCTURES IN PANCREATIC ISLETS . ANNALS OF THE RHEUMATIC DISEASES . vol. 70 ,

Bombardieri M, Kam YNW, Filer A, Buckley CD, Pitzalis C ( 2011 ) . Aberrant Basal and TLR-Stimulated Expression of TSLP in Rheumatoid Synovial Fibroblasts . ARTHRITIS AND RHEUMATISM . vol. 63 , S140 - S140 .

Kam NW, Bombardieri M, Filer A, Buckley C, Pitzalis C ( 2011 ) . Aberrant basal and TLR-stimulated expression of TSLP in rheumatoid synovial fibroblasts . IMMUNOLOGY . vol. 135 , 125 - 125 .

Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M ( 2011 ) . Analysis of recombinant monoclonal antibodies from single B cells reveals early defects of B cell tolerance checkpoints in patients with Sjogren's syndrome . IMMUNOLOGY . vol. 135 , 72 - 72 .

Croia C, Bombardieri M, Serafini B, Coccia EM, Severa M, Kelly S, Aloisi F, Pitzalis C ( 2011 ) . EBV Infection In the Rheumatoid Synovium: Relationship with Ectopic Lymphoid Structures, In Situ Autoantobody Production and CD8 T Cell Activation . ARTHRITIS AND RHEUMATISM . vol. 63 , S140 - S140 .

Nayar S, Barone F, Choy P, Chang M-M, Bombardieri M, Lucchesi D, Pitzalis C, Buckley C ( 2011 ) . Ectopic lymphoneogenesis in a novel murine model of salivary glands sialoadenitis is characterized by asynchrony in the lymphangiogenetic and angiogenetic program . IMMUNOLOGY . vol. 135 , 49 - 49 .

Bombardieri M, Lucchesi D, Barone F, Nayar S, Proctor G, Buckley CD, Pitzalis C ( 2011 ) . Inducible functional tertiary lymphoid structures, autoimmunity and exocrine dysfunction in wild-type mouse salivary glands via local adenoviral delivery . IMMUNOLOGY . vol. 135 , 167 - 167 .

Bugatti S, Manzo A, Bombardieri M, Vitolo B, Humby F, Kelly S, Montecucco C, Pitzalis C ( 2011 ) . Synovial Tissue Heterogeneity and Peripheral Blood Biomarkers . CURRENT RHEUMATOLOGY REPORTS vol. 13 , ( 5 ) 440 - 448 .

Patel HB, Bombardieri M, Sampaio ALF, D'Acquisto F, Gray M, Grieco P, Getting SJ, Pitzalis C et al. ( 2010 ) . Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis . FASEB J vol. 24 , ( 12 ) 4835 - 4843 .

Corsiero E, Bombardieri M, Humby F, Manzo A, Kelly S, Pitzalis C ( 2010 ) . Characterization of inter follicular large B cells, a new subpopulation of B lymphocytes, in tertiary lymphoid organs in rheumatic autoimmune diseases . IMMUNOLOGY . vol. 131 , 33 - 33 .

Astorri E, Guglielmi C, Bombardieri M, Alessandri C, Buzzetti R, Maggi D, Valesini G, Pitzalis C et al. ( 2010 ) . Circulating Reg1α proteins and autoantibodies to Reg1α proteins as biomarkers of β-cell regeneration and damage in type 1 diabetes . Horm Metab Res vol. 42 , ( 13 ) 955 - 960 .

Croia C, Serafini B, Bombardieri M, Kelly S, Coccia EM, Severa M, Aloisi F, Pitzalis C ( 2010 ) . EBV infection in the rheumatoid arthritis synovium: relationship to tertiary lymphoid structures and CD8 T cell activation . IMMUNOLOGY . vol. 131 , 124 - 124 .

Astorri E, Bombardieri M, Gabba S, Peakman M, Pozzilli P, Pitzalis C ( 2010 ) . Evolution of ectopic lymphoid neogenesis and in-situ autoantibodies production in autoimmune diabetic NOD mice: cellular and molecular characterization of tertiary lymphoid structures in pancreatic islet . IMMUNOLOGY . vol. 131 , 63 - 63 .

Ciccia F, Accardo-Palumbo A, Giardina A, Di Maggio P, Principato A, Bombardieri M, Rizzo A, Alessandro R et al. ( 2010 ) . Expansion of Intestinal CD4+CD25(high) Treg Cells in Patients With Ankylosing Spondylitis A Putative Role for Interleukin-10 in Preventing Intestinal Th17 Response . ARTHRITIS RHEUM-US vol. 62 , ( 12 ) 3625 - 3634 .

Lucchesi D, Astorri E, Bombardieri M, Corsiero E, Barone F, Proctor G, Pitzalis C ( 2010 ) . Molecular and cellular evolution of functional tertiary lymphoid structures in salivary glands of NOD mice . IMMUNOLOGY . vol. 131 , 59 - 59 .

Kam NW, Bombardieri M, Brentano F, Choi K, Kyburz D, Gay S, Mclnnes IB, Pitzalis C ( 2010 ) . Rheumatoid synovial fibroblasts support AID expression and Ig class-switching in B cells via a Baff-dependent TLR3-stimulated pathway . IMMUNOLOGY . vol. 131 , 71 - 71 .

Ciccia F, Bombardieri M, Rizzo A, Principato A, Giardina AR, Raiata F, Peralta S, Ferrante A et al. ( 2010 ) . Over-expression of paneth cell-derived anti-microbial peptides in the gut of patients with ankylosing spondylitis and subclinical intestinal inflammation . Rheumatology (Oxford) vol. 49 , ( 11 ) 2076 - 2083 .

Hendler A, Mulli TK, Hughes FJ, Perrett D, Bombardieri M, Houri-Haddad Y, Weiss EI, Nissim A ( 2010 ) . Involvement of Autoimmunity in the Pathogenesis of Aggressive Periodontitis . Journal of Dental Research vol. 89 , ( 12 ) 1389 - 1394 .

Astorri E, Bombardieri M, Gabba S, Peakman M, Pozzilli P, Pitzalis C ( 2010 ) . Evolution of ectopic lymphoid neogenesis and in situ autoantibody production in autoimmune nonobese diabetic mice: cellular and molecular characterization of tertiary lymphoid structures in pancreatic islets . J Immunol vol. 185 , ( 6 ) 3359 - 3368 .

Patel HB, Bombardieri M, Sampaio ALF, D’Acquisto F, Gray M, Grieco P, Getting SJ, Pitzalis C et al. ( 2010 ) . Anti‐inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis . The FASEB Journal vol. 24 , ( 12 ) 4835 - 4843 .

Mahoney DJ, Swales C, Athanasou N, Bombardieri M, Pitzalis C, Kliskey K, Sharif M, Day A et al. ( 2010 ) . TSG-6 inhibits osteoclast activity via an autocrine mechanism and is functionally synergistic with OPG . Bone vol. 47 ,

Astorri E, Bombardieri M, Corsiero E, Gabba S, Barone F, Proctor G, Pitzalis C ( 2010 ) . MOLECULAR AND CELLULAR EVOLUTION OF FUNCTIONAL TERTIARY LYMPHOID STRUCTURES IN SALIVARY GLANDS OF NOD MICE . RHEUMATOLOGY . vol. 49 , I28 - I28 .

Bombardieri M, Kam YNW, Brentano F, Choi K, Kyburz D, Gay S, McInnes IB, Pitzalis C ( 2010 ) . RHEUMATOID SYNOVIAL FIBROBLASTS SUPPORT AID EXPRESSION AND IG CLASS-SWITCHING IN B CELLS VIA A BAFF-DEPENDENT TLR3-STIMULATED PATHWAY . RHEUMATOLOGY . vol. 49 , I26 - I27 .

Swales C, Mahoney DJ, Athanasou NA, Bombardieri M, Pitzalis C, Sharif O, Day AJ, Milner CM et al. ( 2010 ) . TSG-6: AN AUTOCRINE REGULATOR OF INFLAMMATORY JOINT DISEASE? . RHEUMATOLOGY . vol. 49 , I27 - I27 .

Bombardieri M, Astorri E, Corsiero E, Gabba S, Barone F, Proctor G, Pitzalis C ( 2010 ) . MOLECULAR AND CELLULAR EVOLUTION OF FUNCTIONAL TERTIARY LYMPHOID STRUCTURES IN SALIVARY GLANDS OF NOD MICE . ANNALS OF THE RHEUMATIC DISEASES . vol. 69 ,

Manzo A, Bombardieri M, Humby F, Pitzalis C ( 2010 ) . Secondary and ectopic lymphoid tissue responses in rheumatoid arthritis: from inflammation to autoimmunity and tissue damage/remodeling . IMMUNOL REV vol. 233 , 267 - 285 .

Priori R, Alessandri C, Magrini L, Cassara EAM, Ceccarelli F, Modesti M, Croia C, Bombardieri M et al. ( 2009 ) . Nucleosome accumulation and reduction of C-reactive protein are associated with the generation of anti-nuclear antibodies in patients with rheumatoid arthritis treated with adalimumab, but not with etanercept . ANN RHEUM DIS vol. 68 , ( 9 ) 1514 - 1516 .

Alessandri C, Bombardieri M, Scrivo R, Viganego F, Conti F, De Luca N, Riccieri V, Valesini G ( 2009 ) . Anti-carbonic Anhydrase II Antibodies in Systemic Sclerosis: Association with Lung Involvement . Autoimmunity vol. 36 , ( 2 ) 85 - 89 .

Patel HB, Bombardieri M, Pitzalis C, Perretti M ( 2009 ) . Activation of melanocortin receptor type 3 as a new strategy to control experimental and rheumatoid arthritis . EUR J CLIN INVEST vol. 39 , 29 - 29 .

Bombardieri M, Ciccia F, Principato A, Tripodo C, Peralta S, Triolo G, Pitzalis C ( 2009 ) . IL-23 OVEREXPRESSION AS IMMUNOLOGICAL SIGNATURE OF SUBCLINICAL INTESTINAL INFLAMMATION IN ANKYLOSING SPONDYLITIS . RHEUMATOLOGY . vol. 48 , I6 - I6 .

Ciccia F, Bombardieri M, Principato A, Giardina A, Tripodo C, Porcasi R, Peralta S, Franco V et al. ( 2009 ) . Overexpression of Interleukin-23, but Not Interleukin-17, as an Immunologic Signature of Subdinical Intestinal Inflammation in Ankylosing Spondylitis . ARTHRITIS RHEUM vol. 60 , ( 4 ) 955 - 965 .

Conigliaro P, Priori R, Bombardieri M, Alessandri C, Barone F, Pitzalis C, McInnes IB, Valesini G ( 2009 ) . Lymph node IL-18 expression in adult-onset Still’s disease . Annals of the Rheumatic Diseases vol. 68 , ( 3 )

Humby F, Bombardieri M, Manzo A, Kelly S, Blades MC, Kirkham B, Spencer J, Pitzalis C ( 2009 ) . Ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synovium . PLoS Med vol. 6 , ( 1 )

Guglielmi C, Astorri E, Portuesi R, Bombardieri M, Valorani M, Pozzilli P ( 2008 ) . A diet rich in protein and poor in starch with reduced food intake prevents diabetes in the NOD moose: the significance of Reg gene expression in the pancreas . DIABETOLOGIA vol. 51 , S229 - S229 .

Humby F, Bombardieri M, Antonio M, Blades M, Bruce K, Spencer J, Pitzalis C ( 2008 ) . Ectopic lymphoid structures expressing AID drive self sustained in situ prodction of autoantibodies in rheumatoid synovium . ARTHRITIS AND RHEUMATISM . vol. 58 , S633 - S634 .

Lymphoma RTRTALBOISS-RMSAL-GPB-C, Quartuccio L, Fabris M, Moretti M, Barone F, Bombardieri M, Rupolo M, Lombardi S et al. ( 2008 ) . Resistance to Rituximab Therapy and Local BAFF Overexpression in Sjögren’s Syndrome-Related Myoepithelial Sialadenitis and Low-Grade Parotid B-Cell Lymphoma . The Open Rheumatology Journal vol. 2 , ( 1 ) 38 - 43 .

Bombardieri M, Barone F, Humby F, Morgan P, Challacombe S, Spencer J, Pitzalis C ( 2008 ) . Activation-induced cytidine deaminase expression supports functionality of ectopic lymphoid neogenesis in patients with and animal models of Sjogren's syndrome . RHEUMATOLOGY . vol. 47 , II85 - II85 .

Humby F, Bombardieri M, Manzo A, Blades M, Kirkham B, Spencer J, Pitzalis C ( 2008 ) . Activation-induced cytidine deaminase supports self sustained autoantibody production within RA synovium . RHEUMATOLOGY . vol. 47 , II59 - II59 .

Barone F, Bombardieri M, Rosado MM, Morgan PR, Challacombe SJ, De Vita S, Carsetti R, Spencer J et al. ( 2008 ) . CXCL13, CCL21, and CXCL12 expression in salivary glands of patients with Sjogren's syndrome and MALT lymphoma: Association with reactive and malignant areas of lymphoid organization . J IMMUNOL vol. 180 , ( 7 ) 5130 - 5140 .

Bombardieri M, Barone F, Pitzalis C ( 2008 ) . Response to comment on "Activation-Induced Cyridine Deaminase Expression in Follicular Dendritic Cell Networks and Interfollicular Large B Cells Supports Functionality of Ectopic Lymphoid Neogenesis in Autoimmune Sialoadenitis aud MALT Lymphoma in Sjogren's Syndrome" . J IMMUNOL vol. 180 , ( 4 ) 2008 - 2009 .

Astorri E, Bombardieri M, Guglielmi C, Pitzalis C, Pozzilli P ( 2008 ) . Beta cell regeneration in type 1 diabetes: the role of Reg genes in NOD mice . DIABETOLOGIA vol. 51 , S186 - S186 .

Barone F, Bombardieri M, Spencer J, Isaacson P, Humby F, Morgan P, Challacombe S, Valesini G et al. ( 2007 ) . CXCL13, CCL21 and CXCL12 are upregulated in mucosal-associated lymphoid tissue lymphomas in patients with Sjorgen's syndrome and cooperate in the maintenance of the immune response and malignant cell survival . Arthritis Research & Therapy vol. 9 , ( Suppl 3 )

Bombardieri M, Barone F, Humby F, Kelly S, McGurk M, Morgan P, Challacombe S, De Vita S et al. ( 2007 ) . Activation-induced cytidine deaminase expression in follicular dendritic cell networks and interfollicular large B cells supports functionality of ectopic lymphoid neogenesis in autoimmune sialoadenitis and MALT lymphoma in Sjögren's syndrome . J Immunol vol. 179 , ( 7 ) 4929 - 4938 .

Croce A, Firuzi O, Altieri F, Eufemi M, Agostino R, Priori R, Bombardieri M, Alessandri C et al. ( 2007 ) . Effect of infliximab on the glycosylation of IgG of patients with rheumatoid arthritis . Journal of Clinical Laboratory Analysis vol. 21 , ( 5 ) 303 - 314 .

Alessandri C, Sorice M, Bombardieri M, Conigliaro P, Longo A, Garofalo T, Manganelli V, Conti F et al. ( 2006 ) . Antiphospholipid reactivity against cardiolipin metabolites occurring during endothelial cell apoptosis . Arthritis Research & Therapy vol. 8 , ( 6 )

Bombardieri M, McInnes IB, Pitzalis C ( 2006 ) . Interleukin-18 as a potential therapeutic target in chronic autoimmune/inflammatory conditions . Expert Opinion on Biological Therapy vol. 7 , ( 1 ) 31 - 40 .

Alessandri C, Bombardieri M, Valesini G ( 2006 ) . Pathogenic Mechanisms Of Anti‐Endothelial Cell Antibodies (AECA): Their Prevalence And Clinical Relevance . Elsevier

Bombardieri M, Barone F, Carlucci F, Proctor G, van de Loo FA, van den Berg WB, Botto M, Valesini G et al. ( 2006 ) . The IL-18/IL-18R axis is significantly up-regulated in submandibular glands in the nod mouse model of Sjogren's syndrome and is associated with an ongoing TH1-mediated inflammation . RHEUMATOLOGY . vol. 45 , I156 - I156 .

PITZALIS C, Manzo A, Bombardieri M, Valesini G, Challacombe SJ, Morgan PR, Barone F, Blades MC ( 2005 ) . Association of CXCL13 and CCL21 Expression With the Progressive Organization of Lymphoid-like Structures in Sjogren’s Syndrome . Arthritis & Rheumatism vol. 52 , ( 6 ) 1773 - 1784 .

Bombardieri M, Barone F, Proctor G, van de Loo F, van den Berg W, Valesini G, McInnes I, Pitzalis C ( 2005 ) . Efficient IL-18 and IL-18BPc adenoviral gene transfer to cultured murine submandibular gland epithelial cells and successful murine retrograde submandibular duct cannulation to modulate IL-18 function in the salivary gland of animal models of Sjogren's syndrome . Arthritis Research & Therapy vol. 7 , ( Suppl 1 )

Alessandri C, Bombardieri M, Di Prospero L, Conigliaro P, Conti F, Labbadia G, Misasi R, Sorice M et al. ( 2005 ) . Anti-lysobisphosphatidic acid antibodies in patients with antiphospholipid syndrome and systemic lupus erythematosus . Clinical & Experimental Immunology vol. 140 , ( 1 ) 173 - 180 .

Priori R, Bombardieri M, Spinelli FR, Merlin F, Miceli-Richard C, La Cava M, Scavalli AS, Guerrisi R et al. ( 2004 ) . Sporadic Blau syndrome with a double CARD15 mutation. Report of a case with lifelong follow-up . Sarcoidosis, Vasculitis, and Diffuse Lung Diseases vol. 21 , ( 3 ) 228 - 231 .

Barone F, Bombardieri M, Blades M, Manzo A, Morgan P, Challacombe S, Valesini G, Pitzalis C ( 2004 ) . Lymphoid chemokine expression in Sjogren's syndrome: relationship with the lymphoid organization of the periductal inflammatory aggregates . Arthritis Research & Therapy vol. 6 , ( Suppl 3 )

Alessandri C, Bombardieri M, Papa N, Cinquini M, Magrini L, Tincani A, Valesini G ( 2004 ) . Decrease of anti-cyclic citrullinated peptide antibodies and rheumatoid factor following anti-TNFα therapy (infliximab) in rheumatoid arthritis is associated with clinical improvement . Annals of the Rheumatic Diseases vol. 63 , ( 10 )

Bombardieri M, Barone F, Pittoni V, Alessandri C, Conigliaro P, Blades MC, Priori R, McInnes IB et al. ( 2004 ) . Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjögren's syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate . Arthritis Research & Therapy vol. 6 , ( 5 )

Conti F, Alessandri C, Bompane D, Bombardieri M, Spinelli FR, Rusconi AC, Valesini G ( 2004 ) . Autoantibody profile in systemic lupus erythematosus with psychiatric manifestations: a role for anti-endothelial-cell antibodies . Arthritis Research & Therapy vol. 6 , ( 4 )

Bombardieri M, Alessandri C, Labbadia G, Iannuccelli C, Carlucci F, Riccieri V, Paoletti V, Valesini G ( 2004 ) . Role of anti-cyclic citrullinated peptide antibodies in discriminating patients with rheumatoid arthritis from patients with chronic hepatitis C infection-associated polyarticular involvement . Arthritis Research & Therapy vol. 6 , ( 2 )

Spadaro A, Scrivo R, Bombardieri M, Riccieri V, Rinaldi T, Taccari E, Valesini G ( 2003 ) . Relationship of Interleukin-12 and Interleukin-13 imbalance with class-specific rheumatoid factors and anticardiolipin antibodies in systemic lupus erythematosus . Clinical Rheumatology vol. 22 , ( 2 ) 107 - 111 .

Pittoni V, Bombardieri M, Spinelli FR, Scrivo R, Alessandri C, Conti F, Spadaro A, Valesini G ( 2002 ) . Anti-tumour necrosis factor (TNF) α treatment of rheumatoid arthritis (infliximab) selectively down regulates the production of interleukin (IL) 18 but not of IL12 and IL13 . Annals of the Rheumatic Diseases vol. 61 , ( 8 )

Ossandon A, Bombardieri M, Coari G, Graziani G, Valesini G ( 2002 ) . Protein losing enteropathy in systemic lupus erythematosus: role of diet and octreotide . Lupus vol. 11 , ( 7 ) 465 - 466 .