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Publications:  Mr Paul Armstrong

Armstrong PC, Ferreira PM, Chan MV, Lundberg Slingsby MH, Crescente M, Shih C-C, Kirkby NS, Hobbs AJ et al.(2020). Combination of cyclic nucleotide modulators with P2Y12 receptor antagonists as anti-platelet therapy. Journal of thrombosis and haemostasis : JTH vol. 18, (7) 1705-1713.
10.1111/jth.14826
https://qmro.qmul.ac.uk/xmlui/handle/123456789/64692
Crescente M, Armstrong PC, Kirkby NS, Edin ML, Chan MV, Lih FB, Jiao J, Maffucci T et al.(2020). Profiling the eicosanoid networks that underlie the anti- and pro-thrombotic effects of aspirin. The FASEB Journal
10.1096/fj.202000312R
Vulliamy P, Montague SJ, Gillespie S, Chan MV, Coupland LA, Andrews RK, Warner TD, Gardiner EE et al.(2020). Loss of GPVI and GPIbα contributes to trauma-induced platelet dysfunction in severely injured patients. Blood advances vol. 4, (12) 2623-2630.
10.1182/bloodadvances.2020001776
https://qmro.qmul.ac.uk/xmlui/handle/123456789/65273
Chan MV, Chen M-H, Barwari T, Huffman JE, Armstrong PC, Hwang S-J, Santer P, Wierer B et al.(2020). Platelet Reactivity in Individuals Over 65 Years Old Is not Modulated by Age. Circulation Research
10.1161/CIRCRESAHA.119.316324
https://qmro.qmul.ac.uk/xmlui/handle/123456789/64756
Mitchell JA, Shala F, Elghazouli Y, Warner TD, Gaston-Massuet C, Crescente M, Armstrong PC, Herschman HR et al.(2019). Cell-Specific Gene Deletion Reveals the Antithrombotic Function of COX1 and Explains the Vascular COX1/Prostacyclin Paradox. Circulation Research vol. 125, (9) 847-854.
10.1161/CIRCRESAHA.119.314927
https://qmro.qmul.ac.uk/xmlui/handle/123456789/61089
Vulliamy P, Gillespie S, Armstrong P, Allan H, Warner T, Brohi K(2019). Histone H4 induces platelet ballooning and microparticle release during trauma hemorrhage. Proceedings of the National Academy of Sciences
10.1073/pnas.1904978116
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59038
Patel D, Warner TD, Armstrong PC (2019). ICAM-1 contributes to the preferential binding of platelets to classical and intermediate monocyte subsets over neutrophils. BRITISH JOURNAL OF PHARMACOLOGY. Conference: Pharmacology 2018 from: 20/12/2018 to: 18/12/2018, vol. 176, 3038-3039.
10.1111/bph.14681
https://qmro.qmul.ac.uk/xmlui/handle/123456789/63940
Lucotti S, Cerutti C, Soyer M, Gil-Bernabé AM, Gomes AL, Allen PD, Smart S, Markelc B et al.(2019). Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/ thromboxane A<inf>2</inf>. Journal of Clinical Investigation vol. 129, (5) 1845-1862.
10.1172/JCI121985
https://qmro.qmul.ac.uk/xmlui/handle/123456789/57277
Crescente M, Menke L, Chan MV, Armstrong PC, Warner TD(2019). Eicosanoids in platelets and the effect of their modulation by aspirin in the cardiovascular system (and beyond). British Journal of Pharmacology vol. 176, (8) 988-999.
10.1111/bph.14196
https://qmro.qmul.ac.uk/xmlui/handle/123456789/55988
Mitchell JA, Shala F, Elghazouli Y, Armstrong PC, Vadgama A, Herschman HR, Kirkby NS (2018). Renal or Vascular Deletion of COX-2 Increases Thrombotic Tone: Relevance to Cardiovascular Side Effects of Non-Steroidal Anti-Inflammatory Drugs. CIRCULATION. vol. 138,
Barwari T, Eminaga S, Mayr U, Lu R, Armstrong PC, Chan MV, Sahraei M, Fernández-Fuertes M et al.(2018). Inhibition of profibrotic microRNA-21 affects platelets and their releasate. JCI insight vol. 3, (21)
10.1172/jci.insight.123335
https://qmro.qmul.ac.uk/xmlui/handle/123456789/49537
Barwari T, Eminaga S, Lu R, Armstrong PC, Schulte C, Lynch M, Chan MV, Barallobre-Barreiro J et al. (2018). MicroRNA-21 Affects Platelets and Their Releasate: A Novel Mechanism for the Anti-Fibrotic Effects of MicroRNA-21 Inhibition. CIRCULATION RESEARCH. vol. 123,
10.1161/res.123.suppl_1.300
Barwari T, Eminaga S, Armstrong P, Chan M, Lu R, Barallobre-Barreiro J, Yin X, Pechlaner R et al. (2018). MICRORNA-21 REGULATES TRANSFORMING GROWTH FACTOR BETA-1 RELEASE FROM PLATELETS. HEART. vol. 104, A71-A71.
10.1136/heartjnl-2018-BCS.82
Chan MV, Leadbeater PD, Watson SP, Warner TD(2018). Not all light transmission aggregation assays are created equal: qualitative differences between light transmission and 96-well plate aggregometry. Platelets1-4.
10.1080/09537104.2018.1466388
https://qmro.qmul.ac.uk/xmlui/handle/123456789/39405
Chan MV, Armstrong PC, Warner TD(2018). 96-well plate-based aggregometry. Platelets1-6.
10.1080/09537104.2018.1445838
https://qmro.qmul.ac.uk/xmlui/handle/123456789/36591
Lundberg Slingsby MH, Gliemann L, Thrane M, Rytter N, Egelund J, CHAN MV, Armstrong PC, Warner TD et al.(2018). Platelet responses to pharmacological and physiological interventions in middle-aged men with different habitual physical activity levels. Acta Physiol (Oxf)
10.1111/apha.13028
https://qmro.qmul.ac.uk/xmlui/handle/123456789/36395
VULLIAMY P, GILLESPIE S, ARMSTRONG P, CHAN M, DAVENPORT R, WARNER T, BROHI K (2017). Platelets Shift Towards a Procoagulant and Proin ammatory Phenotype at the Expense of Aggregation During Trauma Hemorrhage: a Potential Role of Extracellular Histones. Circulation. Conference: American Heart Association Scientific Sessions (Anaheim, CA) from: 11/11/2017 to: 15/11/2017, vol. e448-467,
10.1161/CIR.0000000000000546
Vulliamy P, Gillespie S, Armstrong PC, Chan MV, Davenport RA, Warner TD, Brohi K (2017). Platelets Shift Towards a Procoagulant and Proinflammatory Phenotype at the Expense of Aggregation During Trauma Hemorrhage: a Potential Role of Extracellular Histones. CIRCULATION. vol. 136, E464-E464.
Barwari T, Eminaga S, Armstrong PC, Chan MV, Lu R, Barallobre-Barreiro J, Yin X, Pechlaner R et al. (2017). MicroRNA-21 Regulates Transforming Growth Factor Beta-1 Release From Platelets: A Novel Mechanism for the Anti-Fibrotic Effects of MicroRNA-21 Inhibition. CIRCULATION. vol. 136,
Mitchell JA, Shala F, Ahmetaj-Shala B, Jiao J, Armstrong PC, Chan MV, Crescente M, Warner TD et al. (2017). Novel Tissue-specific Cyclooxygenase-1 Knockout Mice Demonstrate a Dominant Role for Endothelial Cyclooxygenase-1 in Prostacyclin Production. CIRCULATION. vol. 136,
Crescente M, Armstrong PC, CHAN MV, Edin ML, Lih FB, Jiao J, Gaston-Massuet C, Cottrell GS et al. (2017). PLATELET COX-1 KNOCKOUT MOUSE AS A MODEL OF THE EFFECTS OF ASPIRIN IN THE CARDIOVASCULAR SYSTEM. HEART. Conference: BCS Annual Conference, ‘Cardiology at the Extremes' vol. 103, A108-A109.
10.1136/heartjnl-2017-311726.146
Armstrong PC, Hoefer T, Knowles RB, Tucker AT, Hayman MA, Ferreira PM, Chan MV, Warner TD(2017). Newly Formed Reticulated Platelets Undermine Pharmacokinetically Short-Lived Antiplatelet Therapies. Arterioscler Thromb Vasc Biol vol. 37, (5) 949-956.
10.1161/ATVBAHA.116.308763
https://qmro.qmul.ac.uk/xmlui/handle/123456789/22140
Hayman M, Armstrong P, Chan M, Warner T (2017). Functional Analyses of Reticulated Platelets. FASEB JOURNAL. vol. 31,
Knowles R, D'Silva L, Armstrong P, Chan M, Lawrence M, Standford S, Sabre A, Tucker A et al. (2016). PLATELETS AS KEY REGULATORS OF FIBRIN-CLOT ARCHITECTURE AS ASSESSED BY FRACTAL ANALYSIS OF VISCOELASTIC PROPERTIES; EFFECTS OF STANDARD ANTI-PLATELET THERAPIES. HEART. vol. 102, A127-A128.
10.1136/heartjnl-2016-309890.186
Ferreira P, Armstrong P, Chan M, Warner T (2016). SOLUBLE GUANYLATE CYCLASE ACTIVATORS AS COMBINATION ANTI-PLATELET THERAPY WITH P2Y12 INHIBITORS AND PDE INHIBITORS: IN VIVO AND EX VIVO STUDIES. HEART. vol. 102, A118-A119.
10.1136/heartjnl-2016-309890.169
Chan MV, Knowles RBM, Lundberg MH, Tucker AT, Mohamed NA, Kirkby NS, Armstrong PCJ, Mitchell JA et al.(2016). P2Y<inf>12</inf> receptor blockade synergizes strongly with nitric oxide and prostacyclin to inhibit platelet activation. British Journal of Clinical Pharmacology vol. 81, (4) 621-633.
10.1111/bcp.12826
https://qmro.qmul.ac.uk/xmlui/handle/123456789/23621
Warner TD, Armstrong PC, Chan MV, Knowles RB(2016). The importance of endothelium-derived mediators to the efficacy of dual anti-platelet therapy. Expert Review of Hematology vol. 9, (3) 223-225.
10.1586/17474086.2016.1140035
Kaudewitz D, Skroblin P, Bender LH, Barwari T, Willeit P, Pechlaner R, Sunderland NP, Willeit K et al.(2016). Association of MicroRNAs and YRNAs with platelet function. Circulation Research vol. 118, (3) 420-432.
10.1161/CIRCRESAHA.114.305663
https://qmro.qmul.ac.uk/xmlui/handle/123456789/23128
Ahmetaj-Shala B, Kirkby NS, Knowles R, Al'Yamani M, Mazi S, Wang Z, Tucker AT, Mackenzie LS et al.(2015). Reply to letter regarding article, "evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: Novel explanation of cardiovascular side effects associated with anti-inflammatory drugs". Circulation vol. 132, (17) e213-e214.
10.1161/CIRCULATIONAHA.115.017260
https://qmro.qmul.ac.uk/xmlui/handle/123456789/28913
Khanna V, Armstrong PCJ, Warner TD, Curzen N(2015). Prostaglandin E1 potentiates the effects of P2Y12 blockade on ADP-mediated platelet aggregation in vitro: Insights using short thromboelastography. Platelets vol. 26, (7) 689-692.
10.3109/09537104.2014.1001832
Armstrong PCJ, Kirkby NS, Chan MV, Finsterbusch M, Hogg N, Nourshargh S, Warner TD(2015). Novel whole blood assay for phenotyping platelet reactivity in mice identifies ICAM-1 as a mediator of platelet-monocyte interaction. Blood vol. 126, (10) e11-e18.
10.1182/blood-2015-01-621656
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15669
Armstrong PC, Warner TD (2015). Characterising cell-type interactions following platelet activation in a novel low volume whole blood assay. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. vol. 13, 657-657.
Knowles R, Chan M, Lundberg M, Kirkby N, Shih C-C, Armstrong P, Hayman M, Vojnovic I et al. (2015). SYNERGY BETWEEN ENDOTHELIAL MEDIATORS AND P2Y12 RECEPTOR BLOCKADE AS A POTENTIAL DETERMINANT IN TAILORING ANTI-PLATELET THERAPY. HEART. vol. 101, A116-A117.
10.1136/heartjnl-2015-308066.213
Knowles R, Chan M, Hayman M, Armstrong P, Tucker A, Timmis A, Warner T (2015). THE ANTI-PLATELET EFFECTIVENESS OF P2Y12 RECEPTOR BLOCKADE IS STRONGLY INFLUENCED BY THE ENDOTHELIUM- DERIVED MEDIATORS NITRIC OXIDE AND PROSTACYCLIN. HEART. vol. 101, A90-A91.
Knowles RB, Chan MV, Armstrong PC, Shih C-C, Hayman MA, Vojnovic I, Tucker AT, Timmis AD et al. (2015). The effectiveness of P2Y12 receptor blockade is strongly determined by the presence of endothelial Mediators prostacyclin and nitric oxide. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. vol. 13, 784-784.
Ahmetaj-Shala B, Kirkby NS, Knowles R, Al'Yamani M, Mazi S, Wang Z, Tucker AT, Mackenzie L et al.(2015). Evidence That Links Loss of Cyclooxygenase-2 With Increased Asymmetric Dimethylarginine Novel Explanation of Cardiovascular Side Effects Associated With Anti-Inflammatory Drugs. CIRCULATION vol. 131, (7) 633-U113.
10.1161/CIRCULATIONAHA.114.011591
https://qmro.qmul.ac.uk/xmlui/handle/123456789/9590
Hoefer T, Armstrong PC, Finsterbusch M, Chan MV, Kirkby NS, Warner TD(2015). Drug-free platelets can act as seeds for aggregate formation during antiplatelet therapy. Arteriosclerosis, Thrombosis, and Vascular Biology vol. 35, (10) 2122-2133.
10.1161/ATVBAHA.115.306219
https://qmro.qmul.ac.uk/xmlui/handle/123456789/9199
Ahmetaj-Shala B, Kirkby NS, Knowles R, Al'Yamani M, Mazi S, Wang Z, Tucker AT, Mackenzie L et al. (2015). Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine novel explanation of cardiovascular side effects associated with anti-inflammatory drugs. Circulation. vol. 131, 633-642.
10.1161/CIRCULATIONAHA.114.011591
Ross CL, Galloway-Phillipps N, Armstrong PC, Mitchell JA, Warner TD, Brearley C, Ito M, Tunstall T et al.(2015). Protocol for a human in vivo model of acute cigarette smoke inhalation challenge in smokers with COPD: Monitoring the nasal and systemic immune response using a network biology approach. BMJ Open vol. 5, (1)
10.1136/bmjopen-2014-005750
Knowles RB, Chan MV, Armstrong PC, Shih C-C, Hayman MA, Vojnovic I, Tucker AT, Timmis AD et al. (2014). The Effectiveness of P2Y12 Receptor Antagonist Therapy is Strongly Determined by Endothelial Mediators of Platelet Function. CIRCULATION. vol. 130,
Armstrong PCJ, Hu H, Rivera J, Rigby S, Chen YC, Howden BP, Gardiner E, Peter K(2012). Staphylococcal superantigen-like protein 5 induces thrombotic and bleeding complications in vivo: Inhibition by an anti-SSL5 antibody and the glycan Bimosiamose. Journal of Thrombosis and Haemostasis vol. 10, (12) 2607-2609.
10.1111/jth.12022
Wang X, Hagemeyer CE, Hohmann JD, Leitner E, Armstrong PC, Jia F, Olschewski M, Needles A et al.(2012). Novel single-chain antibody-targeted microbubbles for molecular ultrasound imaging of thrombosis: Validation of a unique noninvasive method for rapid and sensitive detection of thrombi and monitoring of success or failure of thrombolysis in mice. Circulation vol. 125, (25) 3117-3126.
10.1161/CIRCULATIONAHA.111.030312
Armstrong PC, Peter K(2012). GPIIb/IIIa inhibitors: From bench to bedside and back to bench again. Thrombosis and Haemostasis vol. 107, (5) 808-814.
10.1160/TH11-10-0727
Topcic D, Kim W, Holien JK, Jia F, Armstrong PC, Hohmann JD, Straub A, Krippner G et al.(2011). An activation-specific platelet inhibitor that can be turned on/off by medically used hypothermia. Arteriosclerosis, Thrombosis, and Vascular Biology vol. 31, (9) 2015-2023.
10.1161/ATVBAHA.111.226241
Armstrong PC, Kirkby NS, Zain ZN, Emerson M, Mitchell JA, Warner TD(2011). Thrombosis is reduced by inhibition of COX-1, but unaffected by inhibition of COX-2, in an acute model of platelet activation in the mouse. PLoS ONE vol. 6, (5)
10.1371/journal.pone.0020062
https://qmro.qmul.ac.uk/xmlui/handle/123456789/4749
Hu H, Armstrong PCJ, Khalil E, Chen YC, Straub A, Li M, Soosairajah J, Hagemeyer CE et al.(2011). GPVI and GPIBα mediate Staphylococcal superantigen-like protein 5 (SSL5) induced platelet activation and direct toward glycans as potential inhibitors. PLoS ONE vol. 6, (4)
10.1371/journal.pone.0019190
https://qmro.qmul.ac.uk/xmlui/handle/123456789/22199
Armstrong PCJ, Leadbeater PD, Chan MV, Kirkby NS, Jakubowski JA, Mitchell JA, Warner TD(2011). In the presence of strong P2Y12 receptor blockade, aspirin provides little additional inhibition of platelet aggregation. J Thromb Haemost vol. 9, (3) 552-561.
10.1111/j.1538-7836.2010.04160.x
Chan MV, Armstrong PCJ, Papalia F, Kirkby NS, Warner TD(2011). Optical multichannel (optimul) platelet aggregometry in 96-well plates as an additional method of platelet reactivity testing. Platelets vol. 22, (7) 485-494.
10.3109/09537104.2011.592958
Warner TD, Armstrong PCJ, Curzen NP, Mitchell JA(2010). Dual antiplatelet therapy in cardiovascular disease: does aspirin increase clinical risk in the presence of potent P2Y12 receptor antagonists?. Heart vol. 96, (21) 1693-1694.
10.1136/hrt.2010.205724
Moreno L, McMaster SK, Gatheral T, Bailey LK, Harrington LS, Cartwright N, Armstrong PCJ, Warner TD et al.(2010). Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells: comparison with Toll-like receptor 4 responses in macrophages. BRIT J PHARMACOL vol. 160, (8) 1997-2007.
10.1111/j.1476-5381.2010.00814.x
Shinhmar S, Truss N, Armstrong P, Vojnovic I, Warner T (2010). Use of a 96-well plate method for the determination of the anti-platelet effectiveness of a novel NO releasing aspirin molecule. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. vol. 70, 303-303.
Armstrong PCJ, Dhanji ARA, Tucker AT, Mitchell JA, Warner TD(2010). Reduction of platelet thromboxane A(2) production ex vivo and in vivo by clopidogrel therapy. J THROMB HAEMOST vol. 8, (3) 613-615.
10.1111/j.1538-7836.2009.03714.x
Armstrong PCJ, Dhanji AA, Tucker AT, Mitchell JA, Warner TD (2009). URINARY 11-DEHYDRO-THROMBOXANE B2 AS A MARKER OF THE ANTI-PLATELET EFFECTS OF CLOPIDOGREL OR ASPIRIN THERAPY IN HEALTHY MALE VOLUNTEERS. HEART. vol. 95,
10.1136/hrt.2009.178137a
Truss NJ, Armstrong PCJ, Liverani E, Vojnovic I, Warner TD(2009). Heparin but not citrate anticoagulation of blood preserves platelet function for prolonged periods. J THROMB HAEMOST vol. 7, (11) 1897-1905.
10.1111/j.1538-7836.2009.03589.x
Armstrong PCJ, Dhanji AR, Truss NJ, Zain ZNM, Tucker AT, Mitchell JA, Warner TD(2009). Utility of 96-well plate aggregometry and measurement of thrombi adhesion to determine aspirin and clopidogrel effectiveness. THROMB HAEMOSTASIS vol. 102, (4) 772-778.
10.1160/TH09-04-0215
Ali FY, Armstrong PCJ, Dhanji ARA, Tucker AT, Paul-Clark MJ, Mitchell JA, Warner TD(2009). Antiplatelet Actions of Statins and Fibrates Are Mediated by PPARs. ARTERIOSCL THROM VAS vol. 29, (5) 706-711.
10.1161/ATVBAHA.108.183160
Armstrong PCJ, Truss NJ, Ali FY, Dhanji AA, Vojnovic I, Zain ZNM, Bishop-Bailey D, Paul-Clark MJ et al.(2008). Aspirin and the in vitro linear relationship between thromboxane A(2)-mediated platelet aggregation and platelet production of thromboxane A(2). J THROMB HAEMOST vol. 6, (11) 1933-1943.
10.1111/j.1538-7836.2008.03133.x
Zain ZNM, Armstrong PCJ, Pearson NJ, Mitchell JA, Warner TD (2008). Evaluation of aspirin inhibition of platelet aggregation induced by combination of collagen and adrenaline in a 96-well plate format. HEART. vol. 94,
Armstrong PCJ, Zain ZNM, Truss NJ, Vojnovic I, Bishop-Bailey D, Mitchell JA, Warner TD (2008). Linear relationship between platelet aggregation and thromboxane A(2) production. HEART. vol. 94,
Truss NJ, Armstrong PCJ, Zain ZN, Ali FY, Warner TD (2008). Platelet aggregation after storage of whole blood at 4 degrees C. HEART. vol. 94,
Papalia F, Armstrong PCJ, Pearson NJ, Zain ZNM, Ali FY, Vojnovic I, Warner TD (2008). Development of a routine test of platelet reactivity. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. vol. 65, 979-979.
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