Publications: Dr Mark Baker
Austerschmidt LJ, Schottler NI, Miller AM, Baker MD
(
2021
)
.
Changing the firing threshold for normal optic nerve axons by the application of infra-red laser light
.
Scientific Reports
vol.
11
,
(
1
)
Hawkes CH, Baker MD, Giovannoni G, Lechner-Scott J, Levy M
(
2021
)
.
Melatonin and multiple sclerosis
.
Multiple Sclerosis and Related Disorders
vol.
51
,
Austerschmidt LJ, Khan A, Plant DO, Richards EMB, Knott S, Baker MD
(
2020
)
.
The effects of temperature on the biophysical properties of optic nerve F-fibres
.
Scientific Reports
vol.
10
,
(
1
)
Baker MD, Nassar MA
(
2020
)
.
Painful and painless mutations of SCN9A and SCN11A voltage-gated sodium channels
.
Pflugers Archiv European Journal of Physiology
vol.
472
,
(
7
)
865
-
880
.
Plant DO, Khan A, Baker MD
(
2019
)
.
Modification of rat optic nerve axon excitability by blocking I-h using ZD7288
.
British Journal of Pharmacology
.
Conference:
British Pharmacological Society
vol.
176
,
2979
-
2980
.
Bode DC, Stanyon HF, Hirani T, Baker MD, Nield J, Viles JH
(
2018
)
.
Serum Albumin's Protective Inhibition of Amyloid-β Fibre Formation Is Suppressed by Cholesterol, Fatty Acids and Warfarin
.
J Mol Biol
BAKER D
(
2017
)
.
Big conductance calcium-activated potassium channel openers control spasticity without sedation
.
British Journal of Pharmcology
BAKER MD, Kanagaratnam M, Pendleton C, Souza DA, Pettit J, Howells J
(
2017
)
.
Diuretic sensitive electroneutral Na+ movement and temperature effects on central axons
.
The Journal of Physiology
BAKER MD
(
2016
)
.
Ion Channel Formation by Amyloid-β42 Oligomers but not Amyloid-β40 in Cellular Membranes
.
Journal of Biological Chemistry
Park SB, Baker MD
(
2016
)
.
Too fast: rare neuropathic pain state associated with easy activation of NaV1.9
.
J Neurol Neurosurg Psychiatry
Hockley JRF, Tranter MM, McGuire C, Bondouki G, Cibert-Goton V, Thaha MA, Blackshaw L, Michael GJ et al.
(
2016
)
.
P2Y Receptors Sensitize Mouse and Human Colonic Nociceptors
.
Journal of Neuroscience
vol.
36
,
(
8
)
Article
26911685
,
2364
-
2376
.
Coates TA, Woolnough O, Masters JM, Asadova G, Chandrakumar C, Baker MD
(
2015
)
.
Acute temperature sensitivity in optic nerve axons explained by an electrogenic membrane potential
.
Pflugers Archiv European Journal of Physiology
vol.
467
,
(
11
)
2337
-
2349
.
Bulmer D, Hockley J, Mcguire C, Cibert-Goton V, Tranter M, Knowles C, Baker M, Mcmurray S et al.
(
2015
)
.
Differential roles of voltage-gated sodium channels on visceral afferent excitability to mechanical and inflammatory mediators
.
NEUROGASTROENTEROLOGY AND MOTILITY
vol.
27
,
110
-
110
.
Hockley JRF, Boundouki G, Cibert-Goton V, McGuire C, Yip PK, Chan C, Tranter M, Wood JN et al.
(
2014
)
.
Multiple roles for Na<inf>V</inf>1.9 in the activation of visceral afferents by noxious inflammatory, mechanical, and human disease-derived stimuli
.
Pain
vol.
155
,
(
10
)
1962
-
1975
.
Hockley JRF, Boundouki G, Cibert-Goton V, McGuire C, Yip PK, Chan C, Tranter M, Wood JN et al.
(
2014
)
.
Multiple roles for NaV1.9 in the activation of visceral afferents by noxious inflammatory, mechanical, and human disease-derived stimuli
.
Pain
vol.
155
,
(
10
)
1962
-
1975
.
Hadavi S, Baker MD, Dobson R
(
2014
)
.
Sustained-release fampridine in Multiple Sclerosis
.
Multiple Sclerosis and Related Disorders
vol.
3
,
(
1
)
17
-
21
.
Baker MD
(
2013
)
.
Potential therapeutic mechanism of K<sup>+</sup> channel block for MS
.
Multiple Sclerosis and Related Disorders
vol.
2
,
(
4
)
270
-
280
.
Bubb KJ, Wen H, Panayiotou CM, Finsterbusch M, Khan FJ, Chan MV, Priestley JV, Baker MD et al.
(
2013
)
.
Activation of neuronal transient receptor potential vanilloid 1 channel underlies 20-hydroxyeicosatetraenoic acid-induced vasoactivity: role for protein kinase A
.
Hypertension
vol.
62
,
(
2
)
426
-
433
.
Pristerà A, Baker MD, Okuse K
(
2013
)
.
Correction: Association between tetrodotoxin resistant channels and lipid rafts regulates sensory neuron excitability (PLoS ONE)
.
PLoS ONE
vol.
8
,
(
5
)
Cibert-Goton V, Hockley JR, Tranter M, Boundouki G, Baker MD, Bulmer DC
(
2013
)
.
A1 and A2A Adenosine Receptor Subtype Selective Agonists Activate Splanchnic Colonic Afferents With a Clear Modulatory Role of Nav1.9
.
GASTROENTEROLOGY
.
vol.
144
,
S297
-
S297
.
Hockley JR, Cibert-Goton V, Boundouki G, Wood J, Knowles CH, Baker MD, Winchester W, Bulmer DC
(
2013
)
.
Mechanotransduction in Mouse Visceral Afferent Fibres Is Modulated by Nav1.9
.
GASTROENTEROLOGY
.
vol.
144
,
S935
-
S935
.
Cibert-Goton V, Hockley JR, Tranter M, Boundouki G, Baker MD, Bulmer DC
(
2013
)
.
Sa1746 A1 and A2A Adenosine Receptor Subtype Selective Agonists Activate Splanchnic Colonic Afferents With a Clear Modulatory Role of Nav1.9
.
Gastroenterology
vol.
144
,
(
5
)
s
-
297
.
Hockley JR, Cibert-Goton V, Boundouki G, Wood J, Knowles CH, Baker MD, Winchester W, Bulmer DC
(
2013
)
.
Tu2121 Mechanotransduction in Mouse Visceral Afferent Fibres Is Modulated by Nav1.9
.
Gastroenterology
vol.
144
,
(
5
)
s
-
935
.
Lidster K, Jackson SJ, Ahmed Z, Munro P, Coffey P, Giovannoni G, Baker MD, Baker D
(
2013
)
.
Neuroprotection in a novel mouse model of multiple sclerosis
.
PLoS One
vol.
8
,
(
11
)
Eijkelkamp N, Linley JE, Baker MD, Minett MS, Cregg R, Werdehausen R, Rugiero F, Wood JN
(
2012
)
.
Neurological perspectives on voltage-gated sodium channels
.
Brain
vol.
135
,
(
Pt 9
)
2585
-
2612
.
Hockley J, Mcguire C, Boundouki G, Knowles C, Baker M, Winchester W, Bulmer D
(
2012
)
.
P2Y mediated activation of mouse and human sensory nerves: Critical role for Nav1.9
.
NEUROGASTROENTEROLOGY AND MOTILITY
vol.
24
,
17
-
18
.
Boundouki G, Hockley J, Mcguire C, Knowles C, Aziz Q, Baker M, Bulmer D
(
2012
)
.
The role of Nav1.9 in the activation of visceral afferent fibres by human inflammatory supernatants
.
NEUROGASTROENTEROLOGY AND MOTILITY
vol.
24
,
41
-
41
.
Pristera A, Baker MD, Okuse K
(
2012
)
.
Association between Tetrodotoxin Resistant Channels and Lipid Rafts Regulates Sensory Neuron Excitability
.
PLOS ONE
vol.
7
,
(
8
)
Article
ARTN e40079
,
Wen H, Östman J, Bubb KJ, Panayiotou C, Priestley JV, Baker MD, Ahluwalia A
(
2012
)
.
20-Hydroxyeicosatetraenoic acid (20-HETE) is a novel activator of transient receptor potential vanilloid 1 (TRPV1) channel
.
J Biol Chem
vol.
287
,
(
17
)
13868
-
13876
.
Baker MD, Waxman SG
(
2012
)
.
Sodium channel slow inactivation and adaptation in C-fibres
.
JOURNAL OF PHYSIOLOGY-LONDON
vol.
590
,
(
7
)
1513
-
1514
.
Baker MD, Chen Y-C, Shah SU, Okuse K
(
2011
)
.
In vitro and intrathecal siRNA mediated K(V)1.1 knock-down in primary sensory neurons
.
Mol Cell Neurosci
vol.
48
,
(
3
)
258
-
265
.
Lidster K, Jackson S, Coffey P, Baker M, Garthwaite J, Selwood D, Giovannoni G, Baker D
(
2011
)
.
Neuroprotection in a novel optic neuritis model
.
MULTIPLE SCLEROSIS JOURNAL
vol.
17
,
S435
-
S435
.
Peiris M, Bulmer DC, Baker MD, Boundouki G, Sinha S, Hobson A, Lee K, Aziz Q et al.
(
2011
)
.
Human visceral afferent recordings: preliminary report
.
Gut
vol.
60
,
(
2
)
204
-
208
.
Boundouki G, Peiris M, Baker MD, Bulmer DC, Aziz Q, Hobson A, Sinha S, Lee K et al.
(
2010
)
.
A novel in vitro model of visceral pain using the human appendix
.
BRITISH JOURNAL OF SURGERY
vol.
97
,
31
-
32
.
Zhao J, Lee M-C, Momin A, Cendan C-M, Shepherd ST, Baker MD, Asante C, Bee L et al.
(
2010
)
.
Small RNAs control sodium channel expression, nociceptor excitability, and pain thresholds
.
J Neurosci
vol.
30
,
(
32
)
10860
-
10871
.
Baker MD, Wen H
(
2010
)
.
Tethered-toxin debut gets cold reception
.
J Physiol
vol.
588
,
(
Pt 10
)
Snape A, Pittaway JF, Baker MD
(
2010
)
.
Excitability parameters and sensitivity to anemone toxin ATX-II in rat small diameter primary sensory neurones discriminated by Griffonia simplicifolia isolectin IB4
.
J Physiol
vol.
588
,
(
Pt 1
)
125
-
137
.
Shao D, Baker MD, Abrahamsen B, Rugiero F, Malik-Hall M, Poon WYL, Cheah KSE, Yao KM et al.
(
2009
)
.
A multi PDZ-domain protein Pdzd2 contributes to functional expression of sensory neuron-specific sodium channel Na(V)1.8
.
MOL CELL NEUROSCI
vol.
42
,
(
3
)
219
-
225
.
Baker MD
(
2009
)
.
Action potential initiation in unmyelinated afferents comes in from the cold
.
J Physiol
vol.
587
,
(
Pt 6
)
Ostman JAR, Nassar MA, Wood JN, Baker MD
(
2008
)
.
GTP up-regulated persistent Na+ current and enhanced nociceptor excitability require NaV1.9
.
J Physiol
vol.
586
,
(
4
)
1077
-
1087
.
Fertleman CR, Baker MD, Parker KA, Moffatt S, Elmslie FV, Abrahamsen B, Ostman J, Klugbauer N et al.
(
2006
)
.
SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes
.
Neuron
vol.
52
,
(
5
)
767
-
774
.
Ekberg J, Jayamanne A, Vaughan CW, Aslan S, Thomas L, Mouldt J, Drinkwater R, Baker MD et al.
(
2006
)
.
mu O-conotoxin MrVIB selectively blocks Na(v)1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits
.
P NATL ACAD SCI USA
vol.
103
,
(
45
)
17030
-
17035
.
Nassar MA, Baker MD, Levato A, Ingram R, Mallucci G, McMahon SB, Wood JN
(
2006
)
.
Nerve injury induces robust allodynia and ectopic discharges in Nav1.3 null mutant mice
.
Mol Pain
vol.
2
,
Foulkes T, Nassar MA, Lane T, Matthews EA, Baker MD, Gerke V, Okuse K, Dickenson AH et al.
(
2006
)
.
Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior
.
J Neurosci
vol.
26
,
(
41
)
10499
-
10507
.
Baker MD
(
2005
)
.
Protein kinase C mediates up-regulation of tetrodotoxin-resistant, persistent Na+ current in rat and mouse sensory neurones
.
J Physiol
vol.
567
,
(
Pt 3
)
851
-
867
.
Baker MD
(
2005
)
.
Ion Currents and Axonal Oscillators: A Possible Biophysical Basis for Positive Signs and Symptoms in Multiple Sclerosis
.
Multiple Sclerosis As A Neuronal Disease
,
Stirling LC, Forlani G, Baker MD, Wood JN, Matthews EA, Dickenson AH, Nassar MA
(
2005
)
.
Nociceptor-specific gene deletion using heterozygous Na(v)1.8-Cre recombinase mice
.
PAIN
vol.
113
,
(
1-2
)
27
-
36
.
Wood JN, Boorman JP, Okuse K, Baker MD
(
2004
)
.
Voltage-gated sodium channels and pain pathways
.
J Neurobiol
vol.
61
,
(
1
)
55
-
71
.
Nassar MA, Stirling LC, Forlani G, Baker MD, Matthews EA, Dickenson AH, Wood JN
(
2004
)
.
Nociceptor-specific gene deletion reveals a major role for Na(v)1.7 (PN1) in acute and inflammatory pain
.
P NATL ACAD SCI USA
vol.
101
,
(
34
)
12706
-
12711
.
Wood JN, Baker MD, Okuse K, Stirling LC, Nassar M
(
2004
)
.
Voltage-gated sodium channels and pain pathways
.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
vol.
18
,
16
-
16
.
Wood JN, Abrahamsen B, Baker MD, Boorman JD, Donier E, Drew LJ, Nassar MA, Okuse K et al.
(
2004
)
.
Ion channel activities implicated in pathological pain
.
Novartis Found Symp
vol.
261
,
32
-
40
.
Wood JN, Abrahamsen B, Baker MD, Boorman JD, Donier E, Drew L, Nassar MA, Okuse K et al.
(
2004
)
.
Mechanisms of hyperalgesia: Regulation of nociceptor activation and excitability
.
HYPERALGESIA: MOLECULAR MECHANISMS AND CLINICAL IMPLICATIONS
.
Editors:
Brune, K, Handwerker, HO
,
vol.
30
,
19
-
26
.
Baker MD, Chandra SY, Ding YN, Waxman SG, Wood JN
(
2003
)
.
GTP-induced tetrodotoxin-resistant Na+ current regulates excitability in mouse and rat small diameter sensory neurones
.
J PHYSIOL-LONDON
vol.
548
,
(
2
)
373
-
382
.
Malik-Hall M, Poon WYL, Baker MD, Wood JN, Okuse K
(
2003
)
.
Sensory neuron proteins interact with the intracellular domains of sodium channel Na(v)1.8
.
MOL BRAIN RES
vol.
110
,
(
2
)
298
-
304
.
Kiernan MC, Baker MD, Bostock H
(
2003
)
.
Characteristics of late Na+ current in adult rat small sensory neurons
.
NEUROSCIENCE
vol.
119
,
(
3
)
653
-
660
.
Baker MD, Chandra SY, Wood JN
(
2002
)
.
Up-regulation of Na+ current attributed to Na(v)1.9 (NaN) changes firing properties of small diameter sensory neurones
.
JOURNAL OF PHYSIOLOGY-LONDON
.
vol.
544
,
74P
-
74P
.
Okuse K, Malik-Hall M, Baker MD, Poon W-YL, Kong H, Chao MV, Wood JN
(
2002
)
.
Annexin II light chain regulates sensory neuron-specific sodium channel expression
.
Nature
vol.
417
,
(
6889
)
653
-
656
.
Baker MD
(
2002
)
.
Electrophysiology of mammalian Schwann cells
.
PROG BIOPHYS MOL BIO
vol.
78
,
(
2-3
)
83
-
103
.
Okuse K, Malik-Hall M, Baker MD, Poon WYL, Kong H, Chao MV, Wood JN
(
2002
)
.
Simulation of adaptive robust estimation procedures in problems of verification of linear-angular measuring instruments
.
Measurement Techniques
vol.
45
,
(
11
)
1132
-
1137
.
Wood JN, Akopian AN, Baker M, Ding Y, Geoghegan F, Nassar M, Malik-Hall M, Okuse K et al.
(
2002
)
.
Sodium channels in primary sensory neurons: relationship to pain states
.
SODIUM CHANNELS AND NEURONAL HYPEREXCITABILITY
vol.
241
,
159
-
172
.
Wood JN, Baker M
(
2001
)
.
Voltage-gated sodium channels
.
Curr Opin Pharmacol
vol.
1
,
(
1
)
17
-
21
.
Baker MD, Wood JN
(
2001
)
.
Involvement of Na+ channels in pain pathways
.
Trends Pharmacol Sci
vol.
22
,
(
1
)
27
-
31
.
BAKER MD, Wood JN
(
2001
)
.
Voltage-gated sodium channels
.
Current Opinion in Pharmacology
vol.
21
,
1
-
17
.
Baker MD
(
2000
)
.
Axonal flip-flops and oscillators
.
Trends in Neurosciences
vol.
23
,
(
11
)
514
-
519
.
Baker MD
(
2000
)
.
Selective block of late Na<sup>+</sup> current by local anaesthetics in rat large sensory neurones
.
British Journal of Pharmacology
vol.
129
,
(
8
)
1617
-
1626
.
Baker MD, Bostock H
(
1999
)
.
The pH dependence of late sodium current in large sensory neurons
.
Neuroscience
vol.
92
,
(
3
)
1119
-
1130
.
Baker MD, Bostock H
(
1998
)
.
Inactivation of macroscopic late Na<sup>+</sup> current and characteristics of unitary late Na<sup>+</sup> currents in sensory neurons
.
Journal of Neurophysiology
vol.
80
,
(
5
)
2538
-
2549
.
Baker MD, Bostock H
(
1997
)
.
Low-threshold, persistent sodium current in rat large dorsal root ganglion neurons in culture
.
Journal of Neurophysiology
vol.
77
,
(
3
)
1503
-
1513
.
Baker MD, Ritchie JM
(
1996
)
.
Characteristics of type I and type II K<sup>+</sup> channels in rabbit cultured Schwann cells
.
Journal of Physiology
vol.
490
,
(
1
)
79
-
95
.
Baker MD, Ritchie JM
(
1994
)
.
The action of capsaicin on type I delayed rectifier K<sup>+</sup> currents in rabbit Schwann cells
.
Proceedings of the Royal Society B: Biological Sciences
vol.
255
,
(
1344
)
259
-
265
.
Baker M, Howe JR, Ritchie JM
(
1993
)
.
Two types of 4‐aminopyridine‐sensitive potassium current in rabbit Schwann cells
.
The Journal of Physiology
vol.
464
,
(
1
)
321
-
342
.
Baker M, Bostock H
(
1992
)
.
Ectopic activity in demyelinated spinal root axons of the rat
.
The Journal of Physiology
vol.
451
,
(
1
)
539
-
552
.
Howe JR, Baker M, Ritchie JM
(
1992
)
.
On the block of outward potassium current in rabbit Schwann cells by internal sodium ions
.
Proceedings of the Royal Society B: Biological Sciences
vol.
249
,
(
1326
)
309
-
316
.
Bostock H, Baker M, Grafe P, Reid G
(
1991
)
.
Changes in excitability and accommodation of human motor axons following brief periods of ischaemia
.
The Journal of Physiology
vol.
441
,
(
1
)
513
-
535
.
Bostock H, Baker M, Reid G
(
1991
)
.
Changes in excitability of human motor axons underlying post‐ischaemic fasciculations: evidence for two stable states
.
The Journal of Physiology
vol.
441
,
(
1
)
537
-
557
.
Baker M, Bostock H
(
1989
)
.
Depolarization changes the mechanism of accommodation in rat and human motor axons
.
The Journal of Physiology
vol.
411
,
(
1
)
545
-
561
.
Bostock H, Baker M
(
1988
)
.
Evidence for two types of potassium channel in human motor axons in vivo
.
Brain Research
vol.
462
,
(
2
)
354
-
358
.
Baker M, Bostock H, Grafe P, Martius P
(
1987
)
.
Function and distribution of three types of rectifying channel in rat spinal root myelinated axons
.
The Journal of Physiology
vol.
383
,
(
1
)
45
-
67
.