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Publications:  Dr Christopher Bell

Bell C, Lowe R, Adams P, Baccarelli A, Beck S, Bell J, Christensen B, Gladyshev V et al.(2019). DNA methylation aging clocks: challenges and recommendations. Genome Biology Article 249 (2019),
10.1186/s13059-019-1824-y
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62983
Bowler EH, Smith-Vidal A, Lester A, Bell J, Wang Z, Bell CG, Wang Y, Divecha N et al.(2019). Deep proteomic analysis of Dnmt1 mutant/hypomorphic colorectal cancer cells reveals dysregulation of epithelial-mesenchymal transition and subcellular re-localization of Beta-Catenin. Epigenetics1-15.
10.1080/15592294.2019.1656154
https://qmro.qmul.ac.uk/xmlui/handle/123456789/60939
Curtis EM, Krstic N, Cook E, D'Angelo S, Crozier SR, Moon RJ, Murray R, Garratt E et al.(2019). Gestational Vitamin D Supplementation Leads to Reduced Perinatal RXRA DNA Methylation: Results From the MAVIDOS Trial. Journal of Bone and Mineral Research vol. 34, (2) 231-240.
10.1002/jbmr.3603
https://qmro.qmul.ac.uk/xmlui/handle/123456789/61072
Curtis EM, Titcombe P, Edwards M, Barton S, Tsai P-C, Dennison EM, Bell J, Spector T et al. (2018). DNA METHYLATION AND ITS RELATIONSHIP WITH MUSCULOSKELETAL HEALTH IN OLDER ADULTS FROM THE HERTFORDSHIRE COHORT STUDY: FINDINGS FROM AN EPIGENOME-WIDE ASSOCIATION STUDY. RHEUMATOLOGY. vol. 57,
Thurner M, van de Bunt M, Torres JM, Mahajan A, Nylander V, Bennett AJ, Gaulton KJ, Barrett A et al.(2018). Integration of human pancreatic islet genomic data refines regulatory mechanisms at type 2 diabetes susceptibility loci. eLife vol. 7,
10.7554/eLife.31977
https://qmro.qmul.ac.uk/xmlui/handle/123456789/32245
Bell CG, Gao F, Yuan W, Roos L, Acton RJ, Xia Y, Bell J, Ward K et al.(2018). Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci. Nature Communications vol. 9, (1)
10.1038/s41467-017-01586-1
https://qmro.qmul.ac.uk/xmlui/handle/123456789/61067
Simner C, Novakovic B, Lillycrop KA, Bell CG, Harvey NC, Cooper C, Saffery R, Lewis RM et al.(2017). DNA methylation of amino acid transporter genes in the human placenta. Placenta vol. 60, 64-73.
10.1016/j.placenta.2017.10.010
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62231
Curtis E, Krstic N, Cook E, D'Angelo S, Crozier S, Moon R, Murray R, Garratt E et al. (2017). Maternal gestational vitamin D supplementation alters perinatal RXRA DNA methylation: findings from the MAVIDOS trial. JOURNAL OF BONE AND MINERAL RESEARCH. vol. 32, S61-S61.
Bell CG(2017). The Epigenomic Analysis of Human Obesity. Obesity vol. 25, (9) 1471-1481.
10.1002/oby.21909
https://qmro.qmul.ac.uk/xmlui/handle/123456789/60940
Curtis E, Cook E, Krstic N, D'Angelo S, Crozier S, Moon R, Murray R, Garratt E et al. (2017). DNA METHYLATION AT THE RXRA PROMOTER AT BIRTH IS ASSOCIATED WITH GESTATIONAL VITAMIN D SUPPLEMENTATION: RESULTS FROM THE MAVIDOS TRIAL. OSTEOPOROSIS INTERNATIONAL. vol. 28, S72-S73.
Curtis E, Titcombe P, Edwards M, Barton S, Tsai P, Dennison E, Bell J, Spector T et al. (2017). RELATIONSHIPS BETWEEN DNA METHYLATION AND MUSCULOSKELETAL HEALTH FROM AN EPIGENOME WIDE ASSOCIATION STUDY: THE HERTFORDSHIRE COHORT. OSTEOPOROSIS INTERNATIONAL. vol. 28, S478-S479.
Curtis EM, Murray R, Titcombe P, Cook E, Clarke-Harris R, Costello P, Garratt E, Holbrook JD et al.(2017). Perinatal DNA Methylation at CDKN2A Is Associated With Offspring Bone Mass: Findings From the Southampton Women's Survey. Journal of Bone and Mineral Research vol. 32, (10) 2030-2040.
10.1002/jbmr.3153
https://qmro.qmul.ac.uk/xmlui/handle/123456789/61074
Cook E, Curtis EM, Krstic N, D'Angelo S, Crozier SR, Moon RJ, Murray R, Garratt E et al. (2017). PERINATAL DNA METHYLATION AT THE RXRA PROMOTER IS ASSOCIATED WITH GESTATIONAL VITAMIN D SUPPLEMENTATION: RESULTS FROM THE MAVIDOS TRIAL. RHEUMATOLOGY. vol. 56, 112-112.
Roos L, Sandling JK, Bell CG, Glass D, Mangino M, Spector TD, Deloukas P, Bataille V et al.(2016). Higher Nevus Count Exhibits a Distinct DNA Methylation Signature in Healthy Human Skin: Implications for Melanoma. Journal of Investigative Dermatology vol. 137, (4) 910-920.
10.1016/j.jid.2016.11.029
https://qmro.qmul.ac.uk/xmlui/handle/123456789/61076
Bell CG(2016). Insights in human epigenomic dynamics through comparative primate analysis. Genomics vol. 108, (3-4) 115-125.
10.1016/j.ygeno.2016.09.003
https://qmro.qmul.ac.uk/xmlui/handle/123456789/60941
Bell CG, Xia Y, Yuan W, Gao F, Ward K, Roos L, Mangino M, Hysi PG et al.(2016). Novel regional age-associated DNA methylation changes within human common disease-associated loci. Genome Biology vol. 17, (1)
10.1186/s13059-016-1051-8
https://qmro.qmul.ac.uk/xmlui/handle/123456789/61075
Livshits G, Gao F, Malkin I, Needhamsen M, Xia Y, Yuan W, Bell CG, Ward K et al.(2016). Contribution of Heritability and Epigenetic Factors to Skeletal Muscle Mass Variation in United Kingdom Twins. Journal of Clinical Endocrinology and Metabolism vol. 101, (6) 2450-2459.
10.1210/jc.2016-1219
https://qmro.qmul.ac.uk/xmlui/handle/123456789/60825
Maiarù M, Tochiki KK, Cox MB, Annan LV, Bell CG, Feng X, Hausch F, Géranton SM(2016). The stress regulator FKBP51 drives chronic pain by modulating spinal glucocorticoid signaling. Science Translational Medicine vol. 8, (325)
10.1126/scitranslmed.aab3376
Roos L, van Dongen J, Bell CG, Burri A, Deloukas P, Boomsma DI, Spector TD, Bell JT(2016). Integrative DNA methylome analysis of pan-cancer biomarkers in cancer discordant monozygotic twin-pairs. Clinical Epigenetics vol. 8, (1) 1-16.
10.1186/s13148-016-0172-y
Willemsen G, Ward KJ, Bell CG, Christensen K, Bowden J, Dalgård C, Harris JR, Kaprio J et al.(2015). The Concordance and Heritability of Type 2 Diabetes in 34,166 Twin Pairs From International Twin Registers: The Discordant Twin (DISCOTWIN) Consortium. Twin Research and Human Genetics vol. 18, (6) 762-771.
10.1017/thg.2015.83
Pipinikas CP, Dibra H, Karpathakis A, Feber A, Novelli M, Oukrif D, Fusai G, Valente R et al.(2015). Epigenetic dysregulation and poorer prognosis in DAXX-deficient pancreatic neuroendocrine tumours. Endocrine-Related Cancer vol. 22, (3) L13-L18.
10.1530/ERC-15-0108
Bell CG(2015). The emerging potential for epigenetic therapeutics in noncancer disorders. Drug Discovery in Cancer Epigenetics,
Wilson GA, Butcher LM, Foster HR, Feber A, Roos C, Walter L, Woszczek G, Beck S et al.(2014). Human-specific epigenetic variation in the immunological Leukotriene B4 Receptor (LTB4R/BLT1) implicated in common inflammatory diseases. Genome Medicine vol. 6, (3)
10.1186/gm536
Yuan W, Xia Y, Bell CG, Yet I, Ferreira T, Ward KJ, Gao F, Loomis AK et al.(2014). An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins. Nature Communications vol. 5,
10.1038/ncomms6719
Bell CG, Wilson GA, Beck S(2014). Human-specific CpG 'beacons' identify human-specific prefrontal cortex H3K4me3 chromatin peaks. Epigenomics vol. 6, (1) 21-31.
10.2217/epi.13.74
Roos L, Spector TD, Bell CG(2014). Using epigenomic studies in monozygotic twins to improve our understanding of cancer. Epigenomics vol. 6, (3) 299-309.
10.2217/epi.14.13
Bell CG(2013). Epigenome-wide association studies: Potential insights into human disease. Epigenetics and Complex Traits, vol. 9781461480785,
Bell CG(2012). Epigenomic Factors in Human Obesity. Epigenetics in Human Disease,
Bell CG, Wilson GA, Butcher LM, Roos C, Walter L, Beck S(2012). Human-specific CpG "beacons" identify loci associated with human-specific traits and disease. Epigenetics vol. 7, (10) 1188-1199.
10.4161/epi.22127
Rakyan VK, Beyan H, Down TA, Hawa MI, Maslau S, Aden D, Daunay A, Busato F et al. (2011). Identification of type 1 Diabetes-associated DNA methylation variable positions that precede disease diagnosis. PLoS Genetics. vol. 7,
10.1371/journal.pgen.1002300
Rakyan VK, Beyan H, Down TA, Hawa MI, Maslau S, Aden D, Daunay A, Busato F et al.(2011). Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis. PLoS Genet vol. 7, (9)
10.1371/journal.pgen.1002300
https://qmro.qmul.ac.uk/xmlui/handle/123456789/5415
Bell CG(2011). Accessing and selecting genetic markers from available resources. Methods in Molecular Biology vol. 760, 1-17.
10.1007/978-1-61779-176-5_1
Bell CG(2011). Integration of genomic and epigenomic DNA methylation data in common complex diseases by haplotype-specific methylation analysis. Personalized Medicine vol. 8, (3) 243-251.
10.2217/pme.11.14
Bell CG, Beck S(2010). The epigenomic interface between genome and environment in common complex diseases. Briefings in Functional Genomics vol. 9, (5-6) 477-485.
10.1093/bfgp/elq026
Bell CG (2010). Epigenomic analysis in common complex disease. MUTAGENESIS. vol. 25, 638-638.
Bell CG, Teschendorff AE, Rakyan VK, Maxwell AP, Beck S, Savage DA(2010). Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus. BMC Medical Genomics vol. 3,
10.1186/1755-8794-3-33
https://qmro.qmul.ac.uk/xmlui/handle/123456789/242
Teschendorff AE, Menon U, Gentry-Maharaj A, Ramus SJ, Weisenberger DJ, Shen H, Campan M, Noushmehr H et al.(2010). Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. Genome Research vol. 20, (4) 440-446.
10.1101/gr.103606.109
Bell CG, Finer S, Lindgren CM, Wilson GA, Rakyan VK, Teschendoff AE, Akan P, Stupka E et al.(2010). Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus. PLOS One
10.1371/journal.pone.0014040
https://qmro.qmul.ac.uk/xmlui/handle/123456789/14550
Bell CG, Beck S(2009). Advances in the identification and analysis of allele-specific expression. Genome Medicine vol. 1, (5)
10.1186/gm56
Bell CG, Wood DR, Cheong SJH, Kwan E, Sinosich M, Delprado W, Baumgart KW(2009). Molecular confirmation of pathological specimen integrity in Australasia. Pathology vol. 41, (3) 280-283.
10.1080/00313020902756311
Bell CG, Kwan E, Nolan RC, Baumgart KW(2008). First molecular confirmation of an Australian case of type III hereditary angioedema [1]. Pathology vol. 40, (1) 82-83.
10.1080/00313020701716433
Taylor PJ, Maroulis S, Mullan GL, Pedersen RL, Baumli A, Elakis G, Piras S, Walsh C et al.(2007). Measurement of the clinical utility of a combined mutation detection protocol in carriers of Duchenne and Becker muscular dystrophy. Journal of Medical Genetics vol. 44, (6) 368-372.
10.1136/jmg.2006.047464
Bell CG, Meyre D, Petretto E, Levy-Marchal C, Hercberg S, Charles MA, Boyle C, Weill J et al.(2007). No contribution of angiotensin-converting enzyme (ACE) gene variants to severe obesity: a model for comprehensive case/control and quantitative cladistic analysis of ACE in human diseases. EUR J HUM GENET vol. 15, (3) 320-327.
10.1038/sj.ejhg.5201754
Roscioli T, Cliffe ST, Bloch DB, Bell CG, Mullan G, Taylor PJ, Sarris M, Wang J et al.(2006). Mutations in the gene encoding the PML nuclear body protein Sp110 are associated with immunodeficiency and hepatic veno-occlusive disease. Nature Genetics vol. 38, (6) 620-622.
10.1038/ng1780
Bell CG, Meyre D, Samson C, Boyle C, Lecoeur C, Tauber M, Jouret BA, Jaquet D et al.(2005). Association of melanin-concentrating hormone receptor 15' polymorphism with early-onset extreme obesity. DIABETES vol. 54, (10) 3049-3055.
10.2337/diabetes.54.10.3049
Guérardel A, Barat-Houari M, Vasseur F, Dina C, Vatin V, Clément K, Eberlé D, Vasseur-Delannoy V et al.(2005). Analysis of sequence variability in the CART gene in relation to obesity in a Caucasian population. BMC Genetics vol. 6,
10.1186/1471-2156-6-19
Bell CG, Walley AJ, Froguel P(2005). The genetics of human obesity. Nature Reviews Genetics vol. 6, (3) 221-234.
10.1038/nrg1556
Bell CG, Benzinou M, Siddiq A, Lecoeur C, Dina C, Lemainque A, Clement K, Basdevant A et al.(2004). Genome-wide linkage analysis for severe obesity in French Caucasians finds significant susceptibility locus on chromosome 19q. DIABETES vol. 53, (7) 1857-1865.
10.2337/diabetes.53.7.1857
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