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Publications:  Dr Daniele Bergamaschi

Robinson DJ, Patel A, Purdie KJ, Wang J, Rizvi H, Hufbauer M, Ostano P, Akgül B et al.(2019). Epigenetic Regulation of iASPP-p63 Feedback Loop in Cutaneous Squamous Cell Carcinoma. J Invest Dermatol vol. 139, (8) 1658-1671.e8.
10.1016/j.jid.2019.01.020
Bergamaschi D, Vossenkamper A, Lee WYJ, Wang P, Bochukova E, Warnes G(2019). Simultaneous polychromatic flow cytometric detection of multiple forms of regulated cell death. Apoptosis
10.1007/s10495-019-01528-w
Borg T-M, PATEL A, BERGAMASCHI D, HARWOOD CA (2018). Targeting p63 upregulation may prevent the development of MAPK inhibitor resistance in melanoma. Conference: MAP 2018 - Molecular Analysis for Personalised Therapy
10.1093/annonc/mdy314.017
Patel AV, Borg T-M, Rodolfo M, Posch C, Harwood C, Bergamaschi D (2018). Targeting p63 upregulation may prevent development of mitogen-activated protein kinase inhibitor resistance in melanoma. BRITISH JOURNAL OF DERMATOLOGY. vol. 178, E397-E398.
Rogerson C, Bergamaschi D, O'Shaughnessy RFL(2017). Uncovering mechanisms of nuclear degradation in keratinocytes: A paradigm for nuclear degradation in other tissues. Nucleus1-9.
10.1080/19491034.2017.1412027
Patel A, Harwood CA, Bergamaschi D (2017). p63 signalling in BRAF inhibitor resistant melanoma. JOURNAL OF INVESTIGATIVE DERMATOLOGY. Conference: European Society of Investigative Dermatology 2017 vol. 137, S285-S285.
10.1016/j.jid.2017.07.738
Akinduro O, Harwood CA, O'Shaughnessy R, Bergamaschi D (2016). Epidermal autophagy and nucleophagy. JOURNAL OF INVESTIGATIVE DERMATOLOGY. Conference: European Society of Investigative Dermatology vol. 136, S183-S183.
10.1016/j.jid.2016.06.149
Akinduro O, Sully K, Patel A, Robinson DJ, Chikh A, McPhail G, Braun KM, Philpott MP et al.(2016). Constitutive Autophagy and Nucleophagy during Epidermal Differentiation. J Invest Dermatol vol. 136, (7) 1460-1470.
10.1016/j.jid.2016.03.016
Patel A, Harwood C, Bergamaschi D (2016). P63 contributes to acquired BRAF inhibitor resistance in melanoma. BRITISH JOURNAL OF DERMATOLOGY. Conference: British Society of Investigative Dermatology 2016 vol. 174, E52-E52.
Chikh A, Ferro R, Abbott JJ, Piñeiro R, Buus R, Iezzi M, Ricci F, Bergamaschi D et al.(2016). Class II phosphoinositide 3-kinase C2β regulates a novel signaling pathway involved in breast cancer progression. Oncotarget vol. 7, (14) 18325-18345.
10.18632/oncotarget.7761
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM et al.(2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy vol. 12, (1) 1-222.
10.1080/15548627.2015.1100356
Robinson D, Harwood C, Bergamaschi D (2015). Dissecting the role of iASPP, a novel regulator of epidermal homeostasis, in keratinocyte skin carcinogenesis. BRITISH JOURNAL OF DERMATOLOGY. vol. 172, E42-E42.
Botti E, Fausti F, Spallone G, Levesque M, Bergamaschi D, Guerrini L, Dummer R, Costanzo A (2014). BRAF inhibitors reactivate tumor suppressive and oncogenic p53 activities in melanoma. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 134, S90-S90.
Maurichi A, Miceli R, Camerini T, Mariani L, Patuzzo R, Ruggeri R, Gallino G, Tolomio E et al.(2014). Prediction of survival in patients with thin melanoma: results from a multi-institution study. J Clin Oncol vol. 32, (23) 2479-2485.
10.1200/JCO.2013.54.2340
Chikh A, Sanza P, Raimondi C, Akinduro O, Warnes G, Chiorino G, Byrne C, Harwood CA et al.(2014). IASPP is a novel autophagy mudulator in keratinocytes. J Cell Science (advance online edition)
10.1242/​jcs.144816
Bergamaschi D(2014). Is Mcl-1L the new anti-apoptotic effector of B-RAFV(600E) in melanoma?. Exp Dermatol vol. 23, (2)
10.1111/exd.12312
Akinduro O, Sully K, Chikh A, O'shaughnessy RF, Bergamaschi D, Harwood CA, Philpott MP, Byrne C (2013). Constitutive autophagy as a terminal differentiation mechanism. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 133, S127-S127.
Chikh A, Harwood C, Bergamaschi D (2013). IASPP is a novel autophagy inhibitor in keratinocytes. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 133, S126-S126.
Szentpetery Z, Lovat PE, Bergamaschi D, O'Toole EA (2013). The receptor tyrosine kinase, Axl, as a therapeutic target in malignant melanoma. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 133, S240-S240.
Matin RN, Chikh A, Chong SLP, Mesher D, Graf M, Sanza' P, Senatore V, Scatolini M et al.(2013). p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis. J Exp Med vol. 210, (3) 581-603.
10.1084/jem.20121439
BERGAMASCHI D, Wang, Y, Godin-Heymann N, Dan Wang X, Llanos S, Lu X(2013). ASPP1 and ASPP2 bind active RAS, potentiate RAS signalling and enhance p53 activity in cancer cells. Cell Death and Differentiation vol. 20, (4) 525-534.
10.1038/cdd.2013.3
Akinduro O, Sully K, O'Shaughnessy R, Harwood CA, Bergamaschi D, Byrne C (2012). A Novel Mechanism of Keratinocyte Terminal Differentiation - Autophagy?. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 132, S78-S78.
Matin RN, Chikh A, Chong SLP, Harwood C, Bergamaschi D (2012). p63, a p53 repressor in melanoma which confers chemoresistance and a poor prognosis. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 132, S127-S127.
Matin RN, Chikh A, Law S, Harwood CA, Bergamaschi D (2012). p63, an alternative p53 repressor in melanoma which confers chemoresistance and a poor prognosis. BRITISH JOURNAL OF DERMATOLOGY. vol. 167, 11-12.
Wang H, Lee S, Nigro CL, Lattanzio L, Merlano M, Monteverde M, Matin R, Purdie K et al.(2012). NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity. Br J Cancer vol. 106, (8) 1446-1452.
10.1038/bjc.2012.95
Akinduro O, Sully K, O'Shaughnessy RFL, Harwood CA, Bergamaschi D, Byrne C (2012). Autophagy in epidermis. BRITISH JOURNAL OF DERMATOLOGY. vol. 166, e31-e31.
Matin RN, Chikh A, Law S, Harwood CA, Bergamaschi D (2012). p63, an alternative p53 repressor in melanoma which confers chemoresistance and a poor prognosis. BRITISH JOURNAL OF DERMATOLOGY. vol. 166, e15-e15.
Chikh A, Matin RNH, Senatore V, Hufbauer M, Lavery D, Raimondi C, Ostano P, Mello-Grand M et al.(2011). iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia. EMBO J vol. 30, (20) 4261-4273.
10.1038/emboj.2011.302
Chikh A, Bergamaschi D (2011). iASPP mediates regulation of autophagy in keratinocytes. BRITISH JOURNAL OF DERMATOLOGY. vol. 164, 914-914.
Chikh A, Bergamaschi D (2011). iASPP/p63 auto-regulatory feedback loop is essential for epithelial integrity and autophagy. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 131, S56-S56.
Llanos S, Royer C, Lu M, Bergamaschi D, Lee WH, Lu X(2011). Inhibitory Member of the Apoptosis-stimulating Proteins of the p53 Family (iASPP) Interacts with Protein Phosphatase 1 via a Noncanonical Binding Motif. J Biol Chem. vol. 286, (50) 43039-43044.
10.1074/jbc.M111.270751
Chikh A, Matin R, Harwood CA, Bergamaschi D (2010). iASPP: a novel and essential key regulator of skin homeostasis. BRITISH JOURNAL OF DERMATOLOGY. vol. 162, 914-914.
Matin RN, Chikh A, Warnes G, Proby CM, Leigh IM, Harwood CA, Bergamaschi D (2010). p63 is implicated in apoptotic dysregulation in melanoma. BRITISH JOURNAL OF DERMATOLOGY. vol. 162, 921-921.
Chikh A, Bergamaschi D (2009). A novel Role of iASPP, a key regulator in skin development. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 129, S57-S57.
Matin R, Hajji N, Chikh A, Harwood CA, Bergamaschi D (2008). P63 is implicated in apoptotic deregulation in melanoma. BRITISH JOURNAL OF DERMATOLOGY. vol. 158, 911-912.
Bell HS, Dufes C, O'Prey J, Crighton D, Bergamaschi D, Lu X, Schatzlein AG, Vousden KH et al.(2007). A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo. J CLIN INVEST vol. 117, (4) 1008-1018.
10.1172/JCI28920
Leverrier S, Bergamaschi D, Ghali L, Ola A, Warnes G, Akgul B, Blight K, Garcia-Escudero R et al.(2007). Role of HPV E6 proteins in preventing UVB-induced release of pro-apoptotic factors from the mitochondria. APOPTOSIS vol. 12, (3) 549-560.
10.1007/s10495-006-0004-1
Gubser C, Bergamaschi D, Hollinshead M, Lu X, van Kuppeveld FJM, Smith GL(2007). A new inhibitor of apoptosis from vaccinia virus and eukaryotes. PLoS Pathog vol. 3, (2)
10.1371/journal.ppat.0030017
Bergamaschi D, Samuels Y, Sullivan A, Zvelebil M, Breyssens H, Bisso A, Del Sal G, Syed N et al.(2006). iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72 polymorphic p53. NAT GENET vol. 38, (10) 1133-1141.
10.1038/ng1879
Bergamaschi D, Samuels Y, Zhong S, Lu X(2005). Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation. ONCOGENE vol. 24, (23) 3836-3841.
10.1038/sj.onc.1208535
Zhang WQ, Bergamaschi D, Jin BQ, Lu X(2005). Posttranslational modifications of p27kip1 determine its binding specificity to different cyclins and cyclin-dependent kinases in vivo. BLOOD vol. 105, (9) 3691-3698.
10.1182/blood-2003-07-2558
Slee EA, Gillotin S, Bergamaschi D, Royer C, Llanos S, Ali S, Jin B, Trigiante G et al.(2004). The N-terminus of a novel isoform of human iASPP is required for its cytoplasmic localization. Oncogene vol. 23, (56) 9007-9016.
10.1038/sj.onc.1208088
Sullivan A, Syed N, Gasco M, Bergamaschi D, Trigiante G, Attard M, Hiller L, Farrell PJ et al.(2004). Polymorphism in wild-type p53 modulates response to chemotherapy in vitro and in vivo. Oncogene vol. 23, (19) 3328-3337.
10.1038/sj.onc.1207428
Bergamaschi D, Samuels Y, Jin B, Duraisingham S, Crook T, Lu X(2004). ASPP1 and ASPP2: common activators of p53 family members. Mol Cell Biol vol. 24, (3) 1341-1350.
10.1128/mcb.24.3.1341-1350.2004
Bergamaschi D, Gasco M, Hiller L, Sullivan A, Syed N, Trigiante G, Yulug I, Merlano M et al.(2003). p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis. Cancer Cell vol. 3, (4) 387-402.
10.1016/S1535-6108(03)00079-5
Bergamaschi D, Samuels Y, O'Neil NJ, Trigiante G, Crook T, Hsieh J-K, O'Connor DJ, Zhong S et al.(2003). iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human. Nat Genet vol. 33, (2) 162-167.
10.1038/ng1070
Samuels-Lev Y, O'Connor DJ, Bergamaschi D, Trigiante G, Hsieh JK, Zhong S, Campargue I, Naumovski L et al.(2001). ASPP proteins specifically stimulate the apoptotic function of p53. Mol Cell vol. 8, (4) 781-794.
10.1016/s1097-2765(01)00367-7
Erba E, Bergamaschi D, Bassano L, Damia G, Ronzoni S, Faircloth GT, D'Incalci M(2001). Ecteinascidin-743 (ET-743), a natural marine compound, with a unique mechanism of action. Eur J Cancer vol. 37, (1) 97-105.
10.1016/s0959-8049(00)00357-9
Erba E, Bergamaschi D, Bassano L, Ronzoni S, Di Liberti G, Muradore I, Vignati S, Faircloth G et al.(2000). Isolation and characterization of an IGROV-1 human ovarian cancer cell line made resistant to Ecteinascidin-743 (ET-743). Br J Cancer vol. 82, (10) 1732-1739.
10.1054/bjoc.2000.1224
Erba E, Bergamaschi D, Ronzoni S, Faretta M, Taverna S, Bonfanti M, Catapano CV, Faircloth G et al.(1999). Mode of action of thiocoraline, a natural marine compound with anti-tumour activity. Br J Cancer vol. 80, (7) 971-980.
10.1038/sj.bjc.6690451
Mologni L, Ponzanelli I, Bresciani F, Sardiello G, Bergamaschi D, Gianní M, Reichert U, Rambaldi A et al.(1999). The novel synthetic retinoid 6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) causes apoptosis in acute promyelocytic leukemia cells through rapid activation of caspases. Blood vol. 93, (3) 1045-1061.
Bergamaschi D, Ronzoni S, Taverna S, Faretta M, De Feudis P, Faircloth G, Jimeno J, Erba E et al.(1999). Cell cycle perturbations and apoptosis induced by isohomohalichondrin B (IHB), a natural marine compound. Br J Cancer vol. 79, (2) 267-277.
10.1038/sj.bjc.6690044
Ghielmini M, Colli E, Erba E, Bergamaschi D, Pampallona S, Jimeno J, Faircloth G, Sessa C(1998). In vitro schedule-dependency of myelotoxicity and cytotoxicity of Ecteinascidin 743 (ET-743). Ann Oncol vol. 9, (9) 989-993.
10.1023/A:1008430827281
Faretta M, Bergamaschi D, Taverna S, Ronzoni S, Pantarotto M, Mascellani E, Cappella P, Ubezio P et al.(1998). Characterization of cyclin B1 expression in human cancer cell lines by a new three-parameter BrdUrd/cyclin B1/DNA analysis. Cytometry vol. 31, (1) 53-59.
10.1002/(sici)1097-0320(19980101)31:1<53::aid-cyto7>3.0.co;2-k
Erba E, Bergamaschi D, Ronzoni S, Faretta M, Bassano L, Cappella P, Valoti G, Giavazzi R et al.(1998). Mode of action of Ecteinascidin 743, a natural marine compound with antitumoral activity. ANNALS OF ONCOLOGY vol. 9, 139-139.
Erba E, Bergamaschi D, Ronzoni S, Faretta M, Bassano L, Vikhanskaya F, Jimeno J, Faircloth G et al.(1998). Thiocoraline, a novel DNA polymerase inhibitor with a higher cytotoxic potency against cancer cells with mutated or inactivated p53. ANNALS OF ONCOLOGY vol. 9, 141-141.
Faretta M, Bergamaschi D, Ronzoni S, D'Incalci M, Erba E (1997). Differences in cyclin B1 expression in cells blocked in the G2M phase after treatment with anticancer agent. New three-parametric flow cytometric analysis. Eur J Histochem. vol. 41 Suppl 2, 73-74.
Bergamaschi D, Faretta M, Ronzoni S, Taverna S, De Feudis P, Bonfanti M, Guidi G, Faircloth M et al. (1997). Flow cytometric analysis of cell cycle phase perturbations induced by Thiocoraline, a new marine-derived anticancer compound. Eur J Histochem. vol. 41 Suppl 2, 63-64.
Desiderio MA, Bergamaschi D, Mascellani E, De Feudis P, Erba E, D'Incalci M(1997). Treatment with inhibitors of polyamine biosynthesis, which selectively lower intracellular spermine, does not affect the activity of alkylating agents but antagonizes the cytotoxicity of DNA topoisomerase II inhibitors. Br J Cancer vol. 75, (7) 1028-1034.
10.1038/bjc.1997.176
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