Publications: Dr Daniele Bergamaschi
Ross R, Guo Y, Walker RN, Bergamaschi D, Shaw TJ, Connelly JT
(
2024
)
.
Biomechanical activation of keloid fibroblasts promotes lysosomal remodelling and exocytosis
.
Journal of Investigative Dermatology
Bergamaschi D
(
2024
)
.
Autophagy Modulation in Endothelial Hyperglycemia-Induced Wound-Healing Impairment
.
Journal of Investigative Dermatology
vol.
144
,
(
5
)
929
-
930
.
Bergamaschi D
(
2024
)
.
Improving cancer stem cells killing in malignant melanoma
.
British Journal of Dermatology
vol.
190
,
(
5
)
615
-
616
.
Uddin N, Ostano P, Chiorino G, di Domizio J, Gilliet M, Philpott M, Hannen R, Bergamaschi D
(
2023
)
.
O09 Dynamic impact of chronic inflammation on epidermal autophagy pathway
.
British Journal of Dermatology
vol.
189
,
(
1
)
e7
-
e8
.
Maurichi A, Barretta F, Patuzzo R, Miceli R, Gallino G, Mattavelli I, Leva A, Harwood C et al.
(
2023
)
.
Similar local recurrence and survival in patients with T1 radial growth phase melanoma on head and neck treated with 5 or 10 mm margins: A retrospective study
.
Journal of the European Academy of Dermatology and Venereology
vol.
37
,
(
7
)
1318
-
1326
.
Uddin N, Ostano P, Chiorino G, Philpott M, Hannen R, Bergamaschi D
(
2022
)
.
347 Chronic Inflammation of Keratinocytes Leads to Autophagy Impairment in Psoriasis
.
Journal of Investigative Dermatology
vol.
142
,
(
12
)
Ross R, Bergamaschi D, Shaw TJ, Connelly J
(
2022
)
.
597 Altered mechano-sensing and autophagy in keloid dermal fibroblasts
.
Journal of Investigative Dermatology
vol.
142
,
(
12
)
Begum Uddin N, Ostano P, Chiorino G, Philpott M, Hannen R, Bergamaschi D
(
2022
)
.
ESDR347 - Chronic Inflammation of Keratinocytes Leads to Autophagy Impairment in Psoriasis
.
Chikh A, Sanzà P, Raimondi C, Akinduro O, Warnes G, Chiorino G, Byrne C, Harwood CA et al.
(
2022
)
.
Retraction: iASPP is a novel autophagy inhibitor in keratinocytes
.
Journal of Cell Science
vol.
135
,
(
14
)
Uddin NB, Asher S, Mannella V, Varahan B, Purdie K, Leigh I, Philpott M, Hannen R et al.
(
2022
)
.
Autophagy impairment and dysfunctional stress response in the pathophysiology of psoriasis
.
BRITISH JOURNAL OF DERMATOLOGY
.
vol.
187
,
E26
-
E26
.
Uddin N, Ostano P, Chiorino G, Philpott M, Hannen R, Bergamaschi D
(
2022
)
.
Chronic inflammation impairs autophagy in psoriasis
.
BRITISH JOURNAL OF DERMATOLOGY
.
vol.
186
,
E220
-
E221
.
Scatolini M, Patel A, Grosso E, Mello‐Grand M, Ostano P, Coppo R, Vitiello M, Venesio T et al.
(
2022
)
.
GJB5 association with BRAF mutation and survival in cutaneous malignant melanoma*
.
British Journal of Dermatology
vol.
186
,
(
1
)
117
-
128
.
Bergamaschi D
(
2021
)
.
Autophagy protects from photoageing in skin fibroblasts
.
British Journal of Dermatology
vol.
186
,
(
2
)
211
-
212
.
Mannella V, Boehm K, Celik S, Ali T, Mirza AN, Hasnaouy ME, Kaffa A, Lyu Y et al.
(
2021
)
.
Growth and viability of cutaneous squamous cell carcinoma cell lines display different sensitivities to isoform-specific phosphoinositide 3-kinase inhibitors
.
International Journal of Molecular Sciences
vol.
22
,
(
7
)
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH et al.
(
2021
)
.
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)<sup>1</sup>
.
Autophagy
vol.
17
,
(
1
)
1
-
382
.
Maurichi A, Miceli R, Patuzzo R, Barretta F, Gallino G, Mattavelli I, Barbieri C, Leva A et al.
(
2020
)
.
Analysis of Sentinel Node Biopsy and Clinicopathologic Features as Prognostic Factors in Patients With Atypical Melanocytic Tumors
.
Journal of the National Comprehensive Cancer Network
vol.
18
,
(
10
)
1327
-
1336
.
Maurichi A, Miceli R, Eriksson H, Newton-Bishop J, Nsengimana J, Chan M, Hayes AJ, Heelan K et al.
(
2020
)
.
Reply to E. Hindié
.
Journal of Clinical Oncology
vol.
38
,
(
27
)
3238
-
3240
.
Patel A, Garcia LF, Mannella V, Gammon L, Borg T-M, Maffucci T, Scatolini M, Chiorino G et al.
(
2020
)
.
Targeting p63 Upregulation Abrogates Resistance to MAPK Inhibitors in Melanoma
.
Cancer Research
vol.
80
,
(
12
)
2676
-
2688
.
Maurichi A, Miceli R, Eriksson H, Newton-Bishop J, Nsengimana J, Chan M, Hayes AJ, Heelan K et al.
(
2020
)
.
Factors Affecting Sentinel Node Metastasis in Thin (T1) Cutaneous Melanomas: Development and External Validation of a Predictive Nomogram
.
J Clin Oncol
vol.
38
,
(
14
)
1591
-
1601
.
Rehman A, Cai Y, Hünefeld C, Jedličková H, Huang Y, Teck Teh M, Sharif Ahmad U, Uttagomol J et al.
(
2019
)
.
The desmosomal cadherin desmoglein-3 acts as a keratinocyte anti-stress protein via suppression of p53
.
Cell Death & Disease
vol.
10
,
(
10
)
Scatolini M, Grosso E, Mello-Grand M, Ostano P, Coppo R, Patel A, Vitiello M, Venesio T et al.
(
2019
)
.
GJB5 association with BRAF mutation and survival in cutaneous melanoma
.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
.
Conference:
ESDR 2019 Bordeaux September 2019
vol.
139
,
S296
-
S296
.
Bergamaschi D, Vossenkamper A, Lee WYJ, Wang P, Bochukova E, Warnes G
(
2019
)
.
Simultaneous polychromatic flow cytometric detection of multiple forms of regulated cell death
.
Apoptosis
Robinson DJ, Patel A, Purdie KJ, Wang J, Rizvi H, Hufbauer M, Ostano P, Akgül B et al.
(
2019
)
.
Epigenetic Regulation of iASPP-p63 Feedback Loop in Cutaneous Squamous Cell Carcinoma
.
Journal of Investigative Dermatology
vol.
139
,
(
8
)
1658
-
1671.e8
.
Jiang Q, Alabi I-KA, Bergamaschi D
(
2019
)
.
Dissecting the integrity of epidermal autophagy in human eczema samples
.
BRITISH JOURNAL OF DERMATOLOGY
.
vol.
180
,
E207
-
E208
.
Mannella V, Bergamaschi D, Harwood C, Maffucci T
(
2019
)
.
Targeting selective phosphoinositide-3-kinase isoforms as a novel strategy in cutaneous squamous cell carcinoma
.
BRITISH JOURNAL OF DERMATOLOGY
.
vol.
180
,
E213
-
E213
.
Borg T-M, PATEL A, BERGAMASCHI D, HARWOOD CA
(
2018
)
.
Targeting p63 upregulation may prevent the development of MAPK inhibitor resistance in melanoma
.
Conference:
MAP 2018 - Molecular Analysis for Personalised Therapy
Rehman A, Cai Y, Jedliková H, Harwood C, Bergamaschi D, Wan H
(
2018
)
.
1347 Desmoglein-3 acts as an anti-stress protein via suppression of p53
.
Journal of Investigative Dermatology
vol.
138
,
(
5
)
S229
-
S229
.
Rehman A, Cai Y, Jedlikova H, Harwood C, Bergamaschi D, Wan H
(
2018
)
.
Desmoglein-3 acts as an anti-stress protein via suppression of p53
.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
.
vol.
138
,
S229
-
S229
.
Knowles O, Doldan P, Hillier-Richardson I, Lunt S, Gammon L, Youssef G, Harwood C, Mackenzie I et al.
(
2018
)
.
Identification of a novel cancer stem cell subpopulation in melanoma pathological specimens
.
BRITISH JOURNAL OF DERMATOLOGY
.
vol.
178
,
E411
-
E411
.
Rehman A, Cai Y, Jedlickova H, Harwood C, Bergamaschi D, Wan H
(
2018
)
.
Novel role of desmoglein-3 acting as a negative regulator of p53
.
BRITISH JOURNAL OF DERMATOLOGY
.
vol.
178
,
E417
-
E418
.
Patel AV, Borg T-M, Rodolfo M, Posch C, Harwood C, Bergamaschi D
(
2018
)
.
Targeting p63 upregulation may prevent development of mitogen-activated protein kinase inhibitor resistance in melanoma
.
BRITISH JOURNAL OF DERMATOLOGY
.
vol.
178
,
E397
-
E398
.
Rogerson C, Bergamaschi D, O'Shaughnessy RFL
(
2017
)
.
Uncovering mechanisms of nuclear degradation in keratinocytes: A paradigm for nuclear degradation in other tissues
.
Nucleus1
-
9
.
Patel A, Harwood CA, Bergamaschi D
(
2017
)
.
p63 signalling in BRAF inhibitor resistant melanoma
.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
.
Conference:
European Society of Investigative Dermatology 2017
vol.
137
,
S285
-
S285
.
Akinduro O, Harwood CA, O'Shaughnessy R, Bergamaschi D
(
2016
)
.
Epidermal autophagy and nucleophagy
.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
.
Conference:
European Society of Investigative Dermatology
vol.
136
,
S183
-
S183
.
Patel A, Harwood C, Bergamaschi D
(
2016
)
.
P63 contributes to acquired BRAF inhibitor resistance in melanoma
.
BRITISH JOURNAL OF DERMATOLOGY
.
Conference:
British Society of Investigative Dermatology 2016
vol.
174
,
E52
-
E52
.
Akinduro O, Sully K, Patel A, Robinson DJ, Chikh A, McPhail G, Braun KM, Philpott MP et al.
(
2016
)
.
Constitutive Autophagy and Nucleophagy during Epidermal Differentiation
.
Journal of Investigative Dermatology
vol.
136
,
(
7
)
1460
-
1470
.
Chikh A, Ferro R, Abbott JJ, Piñeiro R, Buus R, Iezzi M, Ricci F, Bergamaschi D et al.
(
2016
)
.
Class II phosphoinositide 3-kinase C2β regulates a novel signaling pathway involved in breast cancer progression
.
Oncotarget
vol.
7
,
(
14
)
18325
-
18345
.
(
2016
)
.
Erratum
.
Autophagy
vol.
12
,
(
2
)
443
-
443
.
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM et al.
(
2016
)
.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
.
Autophagy
vol.
12
,
(
1
)
1
-
222
.
Robinson D, Harwood C, Bergamaschi D
(
2015
)
.
Dissecting the role of iASPP, a novel regulator of epidermal homeostasis, in keratinocyte skin carcinogenesis
.
BRITISH JOURNAL OF DERMATOLOGY
.
vol.
172
,
E42
-
E42
.
Maurichi A, Miceli R, Camerini T, Mariani L, Patuzzo R, Ruggeri R, Gallino G, Tolomio E et al.
(
2014
)
.
Prediction of survival in patients with thin melanoma: results from a multi-institution study
.
J Clin Oncol
vol.
32
,
(
23
)
2479
-
2485
.
Chikh A, Sanza P, Raimondi C, Akinduro O, Warnes G, Chiorino G, Byrne C, Harwood CA et al.
(
2014
)
.
IASPP is a novel autophagy mudulator in keratinocytes
.
J Cell Science
vol.
127
,
(
14
)
3079
-
3093
.
Bergamaschi D
(
2014
)
.
Is Mcl-1L the new anti-apoptotic effector of B-RAFV(600E) in melanoma?
.
Exp Dermatol
vol.
23
,
(
2
)
Botti E, Fausti F, Spallone G, Levesque M, Bergamaschi D, Guerrini L, Dummer R, Costanzo A
(
2014
)
.
BRAF inhibitors reactivate tumor suppressive and oncogenic p53 activities in melanoma
.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
.
vol.
134
,
S90
-
S90
.
Matin RN, Chikh A, Chong SLP, Mesher D, Graf M, Sanza' P, Senatore V, Scatolini M et al.
(
2013
)
.
p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis
.
J Exp Med
vol.
210
,
(
3
)
581
-
603
.
BERGAMASCHI D, Wang, Y, Godin-Heymann N, Dan Wang X, Llanos S, Lu X
(
2013
)
.
ASPP1 and ASPP2 bind active RAS, potentiate RAS signalling and enhance p53 activity in cancer cells
.
Cell Death and Differentiation
vol.
20
,
(
4
)
525
-
534
.
Akinduro O, Sully K, Chikh A, O'shaughnessy RF, Bergamaschi D, Harwood CA, Philpott MP, Byrne C
(
2013
)
.
Constitutive autophagy as a terminal differentiation mechanism
.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
.
vol.
133
,
S127
-
S127
.
Chikh A, Harwood C, Bergamaschi D
(
2013
)
.
IASPP is a novel autophagy inhibitor in keratinocytes
.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
.
vol.
133
,
S126
-
S126
.
Szentpetery Z, Lovat PE, Bergamaschi D, O'Toole EA
(
2013
)
.
The receptor tyrosine kinase, Axl, as a therapeutic target in malignant melanoma
.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
.
vol.
133
,
S240
-
S240
.
Wang H, Lee S, Nigro CL, Lattanzio L, Merlano M, Monteverde M, Matin R, Purdie K et al.
(
2012
)
.
NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity
.
Br J Cancer
vol.
106
,
(
8
)
1446
-
1452
.
Akinduro O, Sully K, O'Shaughnessy R, Harwood CA, Bergamaschi D, Byrne C
(
2012
)
.
A Novel Mechanism of Keratinocyte Terminal Differentiation - Autophagy?
.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
.
vol.
132
,
S78
-
S78
.
Akinduro O, Sully K, O'Shaughnessy RFL, Harwood CA, Bergamaschi D, Byrne C
(
2012
)
.
Autophagy in epidermis
.
BRITISH JOURNAL OF DERMATOLOGY
.
vol.
166
,
e31
-
e31
.
Matin RN, Chikh A, Chong SLP, Harwood C, Bergamaschi D
(
2012
)
.
p63, a p53 repressor in melanoma which confers chemoresistance and a poor prognosis
.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
.
vol.
132
,
S127
-
S127
.
Matin RN, Chikh A, Law S, Harwood CA, Bergamaschi D
(
2012
)
.
p63, an alternative p53 repressor in melanoma which confers chemoresistance and a poor prognosis
.
BRITISH JOURNAL OF DERMATOLOGY
.
vol.
166
,
e15
-
e15
.
Chikh A, Matin RNH, Senatore V, Hufbauer M, Lavery D, Raimondi C, Ostano P, Mello-Grand M et al.
(
2011
)
.
iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia
.
EMBO J
vol.
30
,
(
20
)
4261
-
4273
.
Chikh A, Bergamaschi D
(
2011
)
.
iASPP mediates regulation of autophagy in keratinocytes
.
BRITISH JOURNAL OF DERMATOLOGY
.
vol.
164
,
914
-
914
.
Chikh A, Bergamaschi D
(
2011
)
.
iASPP/p63 auto-regulatory feedback loop is essential for epithelial integrity and autophagy
.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
.
vol.
131
,
S56
-
S56
.
Llanos S, Royer C, Lu M, Bergamaschi D, Lee WH, Lu X
(
2011
)
.
Inhibitory Member of the Apoptosis-stimulating Proteins of the p53 Family (iASPP) Interacts with Protein Phosphatase 1 via a Noncanonical Binding Motif
.
J Biol Chem.
vol.
286
,
(
50
)
43039
-
43044
.
Chikh A, Matin R, Harwood CA, Bergamaschi D
(
2010
)
.
iASPP: a novel and essential key regulator of skin homeostasis
.
BRITISH JOURNAL OF DERMATOLOGY
.
vol.
162
,
914
-
914
.
Matin RN, Chikh A, Warnes G, Proby CM, Leigh IM, Harwood CA, Bergamaschi D
(
2010
)
.
p63 is implicated in apoptotic dysregulation in melanoma
.
BRITISH JOURNAL OF DERMATOLOGY
.
vol.
162
,
921
-
921
.
Chikh A, Bergamaschi D
(
2009
)
.
A novel Role of iASPP, a key regulator in skin development
.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
.
vol.
129
,
S57
-
S57
.
Matin R, Hajji N, Chikh A, Harwood CA, Bergamaschi D
(
2008
)
.
P63 is implicated in apoptotic deregulation in melanoma
.
BRITISH JOURNAL OF DERMATOLOGY
.
vol.
158
,
911
-
912
.
Philpott MP, Bergamaschi D, Storey A
(
2007
)
.
Models for Skin Cancer
.
The Cancer Handbook
,
Wiley
Bell HS, Dufes C, O'Prey J, Crighton D, Bergamaschi D, Lu X, Schatzlein AG, Vousden KH et al.
(
2007
)
.
A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo
.
J CLIN INVEST
vol.
117
,
(
4
)
1008
-
1018
.
Leverrier S, Bergamaschi D, Ghali L, Ola A, Warnes G, Akgul B, Blight K, Garcia-Escudero R et al.
(
2007
)
.
Role of HPV E6 proteins in preventing UVB-induced release of pro-apoptotic factors from the mitochondria
.
APOPTOSIS
vol.
12
,
(
3
)
549
-
560
.
Gubser C, Bergamaschi D, Hollinshead M, Lu X, van Kuppeveld FJM, Smith GL
(
2007
)
.
A new inhibitor of apoptosis from vaccinia virus and eukaryotes
.
PLoS Pathog
vol.
3
,
(
2
)
Bergamaschi D, Samuels Y, Sullivan A, Zvelebil M, Breyssens H, Bisso A, Del Sal G, Syed N et al.
(
2006
)
.
iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72 polymorphic p53
.
NAT GENET
vol.
38
,
(
10
)
1133
-
1141
.
Bergamaschi D, Samuels Y, Zhong S, Lu X
(
2005
)
.
Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation
.
ONCOGENE
vol.
24
,
(
23
)
3836
-
3841
.
Zhang WQ, Bergamaschi D, Jin BQ, Lu X
(
2005
)
.
Posttranslational modifications of p27kip1 determine its binding specificity to different cyclins and cyclin-dependent kinases in vivo
.
BLOOD
vol.
105
,
(
9
)
3691
-
3698
.
Slee EA, Gillotin S, Bergamaschi D, Royer C, Llanos S, Ali S, Jin B, Trigiante G et al.
(
2004
)
.
The N-terminus of a novel isoform of human iASPP is required for its cytoplasmic localization
.
Oncogene
vol.
23
,
(
56
)
9007
-
9016
.
Sullivan A, Syed N, Gasco M, Bergamaschi D, Trigiante G, Attard M, Hiller L, Farrell PJ et al.
(
2004
)
.
Polymorphism in wild-type p53 modulates response to chemotherapy in vitro and in vivo
.
Oncogene
vol.
23
,
(
19
)
3328
-
3337
.
Bergamaschi D, Samuels Y, Jin B, Duraisingham S, Crook T, Lu X
(
2004
)
.
ASPP1 and ASPP2: common activators of p53 family members
.
Mol Cell Biol
vol.
24
,
(
3
)
1341
-
1350
.
Bergamaschi D, Gasco M, Hiller L, Sullivan A, Syed N, Trigiante G, Yulug I, Merlano M et al.
(
2003
)
.
p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis
.
Cancer Cell
vol.
3
,
(
4
)
387
-
402
.
Bergamaschi D, Samuels Y, O'Neil NJ, Trigiante G, Crook T, Hsieh J-K, O'Connor DJ, Zhong S et al.
(
2003
)
.
iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human
.
Nat Genet
vol.
33
,
(
2
)
162
-
167
.
Samuels-Lev Y, O'Connor DJ, Bergamaschi D, Trigiante G, Hsieh JK, Zhong S, Campargue I, Naumovski L et al.
(
2001
)
.
ASPP proteins specifically stimulate the apoptotic function of p53
.
Mol Cell
vol.
8
,
(
4
)
781
-
794
.
Erba E, Bergamaschi D, Bassano L, Damia G, Ronzoni S, Faircloth GT, D'Incalci M
(
2001
)
.
Ecteinascidin-743 (ET-743), a natural marine compound, with a unique mechanism of action
.
Eur J Cancer
vol.
37
,
(
1
)
97
-
105
.
Erba E, Bergamaschi D, Bassano L, Ronzoni S, Di Liberti G, Muradore I, Vignati S, Faircloth G et al.
(
2000
)
.
Isolation and characterization of an IGROV-1 human ovarian cancer cell line made resistant to Ecteinascidin-743 (ET-743)
.
British Journal of Cancer
vol.
82
,
(
10
)
1732
-
1739
.
Erba E, Bergamaschi D, Ronzoni S, Faretta M, Taverna S, Bonfanti M, Catapano CV, Faircloth G et al.
(
1999
)
.
Mode of action of thiocoraline, a natural marine compound with anti-tumour activity
.
British Journal of Cancer
vol.
80
,
(
7
)
971
-
980
.
Mologni L, Ponzanelli I, Bresciani F, Sardiello G, Bergamaschi D, Giannı́ M, Reichert U, Rambaldi A et al.
(
1999
)
.
The Novel Synthetic Retinoid 6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalene Carboxylic Acid (CD437) Causes Apoptosis in Acute Promyelocytic Leukemia Cells Through Rapid Activation of Caspases
.
Blood
vol.
93
,
(
3
)
1045
-
1061
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