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Research

Publications: Dr Chiara Berlato

Gopinathan G, Berlato C, Lakhani A, Szabova L, Pegrum C, Pedrosa AR, Laforets F, Maniati E et al. ( 2022 ) . Immune Mechanisms of Resistance to Cediranib in Ovarian Cancer . Molecular Cancer Therapeutics vol. 21 , ( 6 ) 1030 - 1045 .
Lecker LSM, Berlato C, Maniati E, Delaine-Smith R, Pearce OMT, Heath O, Nichols SJ, Trevisan C et al. ( 2021 ) . Tgfbi production by macrophages contributes to an immunosuppressive microenvironment in ovarian cancer . Cancer Research vol. 81 , ( 22 ) 5706 - 5719 .
Berlato C, Heath O, Maniati E, Gopinathan G, Kotantaki P, Elorbany S, McDermott J, Pegrum C et al. ( 2021 ) . Murine high grade serous ovarian cancer (HGSOC) models replicate the human tumor microenvironment and suggest anti-tumor activities of macrophages after chemotherapy . CANCER RESEARCH . vol. 81 ,
Heath O, Berlato C, Maniati E, Lakhani A, Pegrum C, Kotantaki P, Elorbany S, Bohm S et al. ( 2021 ) . Chemotherapy induces tumor-associated macrophages that aid adaptive immune responses in ovarian cancer . Cancer Immunology Research vol. 9 , ( 6 ) 665 - 681 .
Pavlyk I, Foster J, Dexter K, Sobasowski J, Bomalarski J, Berlato C, Balkwill F, Szlosarek PW ( 2020 ) . Abstract 2217: Pegylated arginine deiminase sensitizes ASS1-negative and KRAS mutant non-small cell lung cancer to PD-1 blockade immunotherapy . Cancer Research . vol. 80 , 2217 - 2217 .
Maniati E, Berlato C, Gopinathan G, Heath O, Kotantaki P, Lakhani A, McDermott J, Pegrum C et al. ( 2020 ) . Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment . SSRN Electronic Journal
BALKWILL F, Berlato C, Khan MN, Schioppa T, Thompson R, Maniati E, Montfort A, Jangani M et al. ( 2017 ) . A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer . Journal of Clinical Investigation
Berlato C, Kahn MN, Schioppa T, Thompson R, Maniati E, Canosa M, Kulbe H, Sheldon C et al. ( 2014 ) . Abstract 1076: Antagonists of the chemokine receptor CCR4 reverse the tumor-promoting microenvironment of renal cancer . Conference: Tumor Biology1076 - 1076 .
Wong P-P, Miranda F, Chan KV, Berlato C, Hurst HC, Scibetta AG ( 2012 ) . Histone demethylase KDM5B collaborates with TFAP2C and Myc to repress the cell cycle inhibitor p21(cip) (CDKN1A) . Mol Cell Biol vol. 32 , ( 9 ) 1633 - 1644 .
Haffner MC, Jurgeit A, Berlato C, Geley S, Parajuli N, Yoshimura A, Doppler W ( 2008 ) . Interaction and functional interference of glucocorticoid receptor and SOCS1 . J BIOL CHEM vol. 283 , ( 32 ) 22089 - 22096 .
Jurgeit A, Berlato C, Obrist P, Ploner C, Massoner P, Schmoelzer J, Haffner MC, Klocker H et al. ( 2007 ) . Insulin-like growth factor-binding protein-5 enters vesicular structures but not the nucleus . TRAFFIC vol. 8 , ( 12 ) 1815 - 1828 .
Haffner MC, Berlato C, Doppler W ( 2006 ) . Exploiting our knowledge of NF-kappa B signaling for the treatment of mammary cancer . J MAMMARY GLAND BIOL vol. 11 , ( 1 ) 63 - 73 .
Doppler W, Marth C, Daxenbichler G, Obrist P, Berlato C ( 2005 ) . Expression of STAT1 target genes and interferon gamma in human mammary carcinoma tissue . BREAST CANCER RESEARCH . vol. 7 , S36 - S36 .
Berlato C, Jurgeit A, Geley S, Doppler W ( 2005 ) . Lack of evidence for nuclear IGFBP5 in mammary epithelial cells . BREAST CANCER RESEARCH . vol. 7 , S39 - S39 .
Gatto L, Berlato C, Poli V, Tininini S, Kinjyo I, Yoshimura A, Cassatella MA, Bazzoni F ( 2004 ) . Analysis of SOCS-3 promoter responses to interferon gamma . J Biol Chem vol. 279 , ( 14 ) 13746 - 13754 .
Berlato C, Cassatella MA, Kinjyo I, Gatto L, Yoshimura A, Bazzoni F ( 2002 ) . Involvement of suppressor of cytokine signaling-3 as a mediator of the inhibitory effects of IL-10 on lipopolysaccharide-induced macrophage activation . J Immunol vol. 168 , ( 12 ) 6404 - 6411 .
Gasperini S, Crepaldi L, Calzetti F, Gatto L, Berlato C, Bazzoni F, Yoshimura A, Cassatella MA ( 2002 ) . Interleukin-10 and cAMP-elevating agents cooperate to induce suppressor of cytokine signaling-3 via a protein kinase A-independent signal . Eur Cytokine Netw vol. 13 , ( 1 ) 47 - 53 .
Bazzoni F, Berlato C, Gatto L, Cassatella M ( 2001 ) . Suppressor of cytokine signaling (SOCS)3: Role in suppression of macrophage activation by LPS . J LEUKOCYTE BIOL58 - 58 .