Publications: Prof Gareth Sanger
Short E, Calimport S, Bentley B
(
2024
)
.
Defining an ageing-related pathology, disease or syndrome: International Consensus Statement
.
GeroScience1
-
8
.
Kung VWS, Broad J, Makwana R, Palmer A, Baidoo N, Epton S, Elahi S, Chin‐Aleong J et al.
(
2024
)
.
The impact of long‐course chemoradiotherapy on the myenteric plexus, neuromuscular functions and responses to prokinetic drugs in the human rectum
.
United European Gastroenterology Journal
Baidoo N, Sanger GJ
(
2024
)
.
Age-related decline in goblet cell numbers and mucin content of the human colon: Implications for lower bowel functions in the elderly
.
Experimental and Molecular Pathology
vol.
139
,
Baidoo N, Sanger GJ
(
2024
)
.
The human colon: Evidence for degenerative changes during aging and the physiological consequences
.
Neurogastroenterology & Motility
Oldroyd P, Oldroyd S, Meng M, Makwana R, Sanger G, Bulmer D, Malliaras GG, Owens RM
(
2024
)
.
Stretchable Device for Simultaneous Measurements of Contractility and Electrophysiology of Neuromuscular Tissue in the Gastrointestinal Tract
.
Advanced Materials
vol.
36
,
(
19
)
Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF et al.
(
2023
)
.
The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
.
British Journal of Pharmacology
vol.
180
,
(
S2
)
s23
-
s144
.
Baidoo N, Sanger GJ, Belai A
(
2023
)
.
Histochemical and biochemical analysis of collagen content in formalin-fixed, paraffin embedded colonic samples
.
MethodsX
vol.
11
,
Andrews PLR, Golding JF, Sanger GJ
(
2023
)
.
An assessment of the effects of neurokinin1 receptor antagonism against nausea and vomiting: Relative efficacy, sites of action and lessons for future drug development
.
British Journal of Clinical Pharmacology
vol.
89
,
(
12
)
3468
-
3490
.
Makwana R, Sanger GJ
(
2023
)
.
Characterization of rat gastric myogenic contractions and modulation by oxytocin and arginine-vasopressin
.
European Journal of Pharmacology
vol.
955
,
Davenport AP, Kitazawa T, Sanger G
(
2023
)
.
Motilin receptor in GtoPdb v.2023.1
.
IUPHAR/BPS Guide to Pharmacology CITE
vol.
2023
,
(
1
)
Sanger GJ, Andrews PLR
(
2023
)
.
Review article: An analysis of the pharmacological rationale for selecting drugs to inhibit vomiting or increase gastric emptying during treatment of gastroparesis
.
Alimentary Pharmacology & Therapeutics
vol.
57
,
(
9
)
962
-
978
.
Sanger GJ, Andrews PLR
(
2023
)
.
Efficacy and Safety of Drugs for Gastroparesis: Dopamine Receptor Antagonists Should Not Be Considered as a Single Pharmacologic Entity
.
Gastroenterology
vol.
165
,
(
2
)
520
-
521
.
Perez-Ternero C, Aubdool A, Makwana R, Sanger G, Stimson R, Chan L, Moyes A, Hobbs A
(
2023
)
.
C-type natriuretic peptide regulates metabolic homeostasis
.
JOURNAL OF TRANSLATIONAL MEDICINE
.
vol.
21
,
Sanger GJ, Makwana R
(
2023
)
.
Chapter 4A Commentary on The guts of the matter: Contribution of studies on smooth muscle to discoveries in pharmacology by Michael J. Rand and Frederick Mitchelson
.
Drug Action Haemodynamics and Immune Defence
,
Elsevier
Makwana R, Crawley E, Straface M, Gharibans A, Devalia K, Loy J, O'Grady G, Andrews PLR et al.
(
2023
)
.
[Arg<SUP>8</SUP>]-vasopressin and adrenaline act in synergy to increase spontaneous myogenic contractile activity of human isolated stomach: Potential role in nausea
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
180
,
513
-
514
.
Varangot-Reille C, Sanger GJ, Andrews PLR, Herranz-Gomez A, Suso-Martí L, de la Nava J, Cuenca-Martínez F
(
2022
)
.
Neural networks involved in nausea in adult humans: A systematic review
.
Autonomic Neuroscience
vol.
245
,
Andrews PLR, Williams RSB, Sanger GJ
(
2022
)
.
Anti-emetic effects of thalidomide: Evidence, mechanism of action, and future directions
.
Current Research in Pharmacology and Drug Discovery
vol.
3
,
Baidoo N, Sanger GJ, Belai A
(
2022
)
.
The vulnerability of the human taenia coli to alterations in total collagen within the colon of the elderly
.
Acta Histochemica
vol.
124
,
(
8
)
Makwana R, Crawley E, Straface M, Palmer A, Gharibans A, Devalia K, Loy J, O'Grady G et al.
(
2022
)
.
Synergistic augmentation of rhythmic myogenic contractions of human stomach by arginine vasopressin and adrenaline: Implications for the induction of nausea
.
British Journal of Pharmacology
vol.
179
,
(
24
)
5305
-
5322
.
Baidoo N, Sanger GJ, Belai A
(
2022
)
.
Effect of old age on the subpopulations of enteric glial cells in human descending colon
.
Glia
vol.
71
,
(
2
)
305
-
316
.
Sanger GJ, Andrews PLR
(
2022
)
.
A proposal for rational drug class terminology: A gastrointestinal perspective
.
British Journal of Pharmacology
vol.
179
,
(
23
)
5233
-
5234
.
Baidoo N, Crawley E, Knowles CH, Sanger GJ, Belai A
(
2022
)
.
Total collagen content and distribution is increased in human colon during advancing age
.
PLOS ONE
vol.
17
,
(
6
)
Straface M, Koussai M-A, Makwana R, Crawley E, Palmer A, Cai W, Gharibans A, Adebibe M et al.
(
2022
)
.
A multi-parameter approach to measurement of spontaneous myogenic contractions in human stomach: Utilization to assess potential modulators of myogenic contractions
.
Pharmacological Research
vol.
180
,
Article
106247
,
106247
-
106247
.
Perez-Ternero C, Aubdool AA, Makwana R, Sanger GJ, Stimson RH, Chan LF, Moyes AJ, Hobbs AJ
(
2022
)
.
C-type natriuretic peptide is a pivotal regulator of metabolic homeostasis
.
Proceedings of the National Academy of Sciences of the United States of America
vol.
119
,
(
13
)
Sanger GJ
(
2022
)
.
Why is motilin active in some studies with mice, rats, and guinea pigs, but not in others? Implications for functional variability among rodents
.
Pharmacology Research & Perspectives
vol.
10
,
(
2
)
Sanger GJ, Andrews PLR
(
2022
)
.
Emesis
.
Encyclopedia of Molecular Pharmacology
,
Springer Nature
Cai W, Makwana R, Straface M, Gharibans A, Andrews PLR, Sanger GJ
(
2021
)
.
Evidence for tetrodotoxin‐resistant spontaneous myogenic contractions of mouse isolated stomach that are dependent on acetylcholine
.
British Journal of Pharmacology
vol.
179
,
(
6
)
1187
-
1200
.
Palmer A, Epton S, Crawley E, Straface M, Gammon L, Edgar MM, Xu Y, Elahi S et al.
(
2021
)
.
Expression of p16 Within Myenteric Neurons of the Aged Colon: A Potential Marker of Declining Function
.
Frontiers in Neuroscience
vol.
15
,
747067
-
747067
.
Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF et al.
(
2021
)
.
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors
.
British Journal of Pharmacology
vol.
178
,
(
S1
)
S27
-
S156
.
Davenport AP, Kitazawa T, Sanger G
(
2021
)
.
Motilin receptor in GtoPdb v.2021.2
.
IUPHAR/BPS Guide to Pharmacology CITE
vol.
2021
,
(
2
)
Barnes NM, Ahern GP, Becamel C, Bockaert J, Camilleri M, Chaumont-Dubel S, Claeysen S, Cunningham KA et al.
(
2020
)
.
International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function
.
Pharmacological Reviews
vol.
73
,
(
1
)
310
-
520
.
Davis MP, Sanger GJ
(
2020
)
.
The Benefits of Olanzapine in Palliating Symptoms
.
Current Treatment Options in Oncology
vol.
22
,
(
1
)
Makwana R, Loy J, Adebibe M, Devalia K, Andrews PL, Sanger GJ
(
2020
)
.
Copeptin, a surrogate marker of arginine8 vasopressin, has no ability to modulate human and mouse gastric motility
.
European Journal of Pharmacology
vol.
892
,
Andrews PLR, Cai W, Rudd JA, Sanger GJ
(
2020
)
.
COVID‐19, nausea, and vomiting
.
Journal of Gastroenterology and Hepatology
vol.
36
,
(
3
)
646
-
656
.
Davenport AP, Sanger G
(
2020
)
.
Motilin receptor (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database
.
IUPHAR/BPS Guide to Pharmacology CITE
vol.
2020
,
(
4
)
Sanger G, Andrews P
(
2020
)
.
Emesis
.
Encyclopedia of Molecular Pharmacology.
,
Editors:
Offermanns, S, Rosenthal, W
,
In: Offermanns S., Rosenthal W. (eds) Encyclopedia of Molecular Pharmacology. Springer, Cham
Straface M, Makwana R, Palmer A, Rombolà L, Aleong JC, Morrone LA, Sanger GJ
(
2020
)
.
Inhibition of Neuromuscular Contractions of Human and Rat Colon by Bergamot Essential Oil and Linalool: Evidence to Support a Therapeutic Action
.
Nutrients
vol.
12
,
(
5
)
Choudhry N, Scott F, Edgar M, Sanger GJ, Kelly P
(
2020
)
.
Reversal of Pathogen-Induced Barrier Defects in Intestinal Epithelial Cells by Contra-pathogenicity Agents
.
Digestive Diseases and Sciences
Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF et al.
(
2019
)
.
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors
.
British Journal of Pharmacology
vol.
176
,
(
S1
)
S21
-
S141
.
Cibert-Goton V, Kung VWS, McGuire C, Hockley JRF, Tranter MM, Dogra H, Belai A, Blackshaw LA et al.
(
2019
)
.
Functional and anatomical deficits in visceral nociception with age: a mechanism of silent appendicitis in the elderly?
.
Pain
vol.
161
,
(
4
)
773
-
786
.
Straface M, Makwana R, Rombola L, Chinaleong J, Morrone LA, Sanger GJ
(
2019
)
.
Bergamot essential oil and its constituent linalool, inhibit cholinergically-mediated contractions of human and rat isolated colon
.
NEUROGASTROENTEROLOGY AND MOTILITY
.
Conference:
Neurogastroenterology
vol.
31
,
Palmer A, Straface M, Chin-Aleong J, Knowles C, Sanger GJ
(
2019
)
.
Isolation and culture of primary myenteric neurons and glial cells from human colon: The effects of different concentrations of nerve growth factor
.
NEUROGASTROENTEROLOGY AND MOTILITY
.
Conference:
Neurogastroenterology
vol.
31
,
Makwana R, Elahi S, Adebibe M, Loy J, Sanger GJ
(
2019
)
.
Low concentrations of arginine vasopressin (AVP) act at V1A receptors in human stomach to increase frequency and amplitude of spontaneous rhythmic contractions: Role in nausea
.
NEUROGASTROENTEROLOGY AND MOTILITY
.
Conference:
Neurogastroenterology
(
Lisbon, Portugal
)
from:
05/09/2019
to:
07/09/2019
,
vol.
31
,
Sanger GJ, Andrews PL
(
2019
)
.
Emesis
.
Drug Therapy for Gastrointestinal and Liver Diseases
,
Taylor & Francis
Scott F, Elahi S, Adebibe M, Parampalli U, Mannur K, Góralczyk A, Sanger GJ
(
2019
)
.
Farnesoid X receptor ‐ a molecular predictor of weight loss after vertical sleeve gastrectomy?
.
Obesity Science & Practice
vol.
5
,
(
3
)
273
-
280
.
Ruffle JK, Patel A, Giampietro V, Howard MA, Sanger GJ, Andrews PLR, Williams SCR, Aziz Q et al.
(
2019
)
.
Functional brain networks and neuroanatomy underpinning nausea severity can predict nausea susceptibility using machine learning
.
The Journal of Physiology
vol.
597
,
(
6
)
1517
-
1529
.
Palmer A, Chng S-H, Chin-Aleong J, Knowles C, Pachnis V, Sanger G
(
2019
)
.
Differentiation of neurons from cultured human primary enteric glial cells
.
NEUROGASTROENTEROLOGY AND MOTILITY
.
vol.
31
,
Makwana R, Kouassi M, Elahi S, Adebibe M, Loy J, Sanger G
(
2019
)
.
Increased frequency and amplitude of spontaneous contractions in human stomach by vasopressin acting at V<sub>1A</sub> receptors in low concentrations found in plasma during nausea
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
176
,
3053
-
3054
.
SANGER GJ, BROAD J, KUNG V, Palmer A, ELAHI S, Karami A, Darreh-Shori T, Ahmed S et al.
(
2018
)
.
Changes in neuromuscular structure and functions of human colon during ageing are region-dependent
.
Gut
SANGER GJ, Andrews PLR
(
2018
)
.
A History of Drug Discovery for Treatment of Nausea and Vomiting and the Implications for Future Research
.
Front. Pharmacol. 9:913.
vol.
9
,
Article
913
,
Kouassi M-A, Palmer A, Elahi S, Loy J, Goralczyk A, Adebibe M, Novak P, Sanger G
(
2018
)
.
Interstitial cells of Cajal: Translation of mechanisms regulating function to the human stomach
.
NEUROGASTROENTEROLOGY AND MOTILITY
.
vol.
30
,
Palmer A, Elahi S, Edgar M, Chin-Aleong J, Knowles C, Sanger G
(
2018
)
.
Isolation and culture of human primary neurons and glial cells from the myenteric plexus of the colon for structural, molecular and functional studies
.
NEUROGASTROENTEROLOGY AND MOTILITY
.
vol.
30
,
Alexander SPH, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL et al.
(
2017
)
.
THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview
.
British Journal of Pharmacology
vol.
174
,
S1
-
S16
.
Sanger GJ
(
2017
)
.
Actions of Drugs in the Gastrointestinal Tract
.
Pharmacology for Chemists: Drug Discovery in Context
,
Royal Society of Chemistry (RSC)
Alexander SP, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ et al.
(
2017
)
.
THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Enzymes
.
British Journal of Pharmacology
vol.
174
,
(
Suppl Suppl 1
)
s272
-
s359
.
Palmer A, Ahmed S, Thaha MA, Knowles C, Sanger G
(
2017
)
.
Isolation of myenteric neurons from adult human colon, to investigate changes during advanced age and degenerative disorders
.
NEUROGASTROENTEROLOGY AND MOTILITY
.
Editors:
Galligan, J, Bredenoord, A, Vanner, S
,
Conference:
Neuro Gastro 2017
(
Cork, Ireland
)
from:
24/08/2017
to:
26/08/2017
,
vol.
29
,
96
-
96
.
Liszt KI, Ley JP, Lieder B, Behrens M, Stöger V, Reiner A, Hochkogler CM, Köck E et al.
(
2017
)
.
Caffeine induces gastric acid secretion via bitter taste signaling in gastric parietal cells
.
Proceedings of the National Academy of Sciences
vol.
114
,
(
30
)
E6260
-
E6269
.
Sanger GJ, Pasricha PJ
(
2017
)
.
Investigational drug therapies for the treatment of gastroparesis
.
Expert Opin Investig Drugs
vol.
26
,
(
3
)
331
-
342
.
Kouassi M-A, Palmer A, Broad J, Scott F, Elahi S, Goralczyk A, Adebibe M, Mannur K et al.
(
2017
)
.
Inhibition of human gastric dysrhythmia by sildenafil, not by Ano1 inhibitors
.
NEUROGASTROENTEROLOGY AND MOTILITY
.
vol.
29
,
115
-
115
.
Scott F, Kouassi M-A, Warnes G, Hornsby E, Elahi S, Adedibe M, Goralczyk A, Mannur K et al.
(
2017
)
.
Isolation of human gastric interstitial cells of Cajal
.
NEUROGASTROENTEROLOGY AND MOTILITY
.
vol.
29
,
127
-
127
.
Palmer A, Broad J, Elahi S, Scott F, Knowles C, Sanger G
(
2017
)
.
The effects of ageing on gene expression in the human colon
.
NEUROGASTROENTEROLOGY AND MOTILITY
.
vol.
29
,
96
-
96
.
Broad J, Scott F, Palmer A, Kung V, Kouassi M-A, Elahi S, Knowles C, Sanger G
(
2017
)
.
The effects of the active metabolites of sodium picosulfate and senna on human colorectal neuromuscular activity
.
NEUROGASTROENTEROLOGY AND MOTILITY
.
vol.
29
,
95
-
95
.
Sanger GJ, Broad J, Callaghan B, Furness JB
(
2016
)
.
Ghrelin and Motilin Control Systems in GI Physiology and Therapeutics
.
vol.
239
,
SpringerLink
McGuire C, Boundouki G, Hockley JR, Reed D, Cibert-Goton V, Peiris M, Kung V, Broad J et al.
(
2016
)
.
Ex vivo study of human visceral nociceptors
.
GUT
Article
27654583
,
1
-
11
.
Broad J, Maurel D, Kung VWS, Hicks GA, Schemann M, Barnes MR, Kenakin TP, Granier S et al.
(
2016
)
.
Human native kappa opioid receptor functions not predicted by recombinant receptors: Implications for drug design
.
Scientific Reports
vol.
6
,
(
1
)
Sanger GJ
(
2016
)
.
Chronic constipation: improved understanding offers a new therapeutic approach
.
J Physiol
vol.
594
,
(
15
)
4085
-
4087
.
Broad J, Kung V, Karami A, Darreh-Shori T, Knowles C, Sanger GJ
(
2016
)
.
Region-specific increase in colonic function of choline acetyltransferase in the elderly
.
NEUROGASTROENTEROLOGY AND MOTILITY
.
Conference:
Neurogastro Motility
vol.
28
,
102
-
102
.
Sanger GJ, Twycross R
(
2016
)
.
Making Sense of Emesis, Pruritus, 5-HT and 5-HT3 Receptor Antagonists
.
Progress in Palliative Care
vol.
4
,
(
1
)
7
-
8
.
Hellström PM, Tack J, Johnson LV, Hacquoil K, Barton ME, Richards DB, Alpers DH, Sanger GJ et al.
(
2016
)
.
The pharmacodynamics, safety and pharmacokinetics of single doses of the motilin agonist, camicinal, in type 1 diabetes mellitus with slow gastric emptying
.
British Journal of Pharmacology
vol.
173
,
(
11
)
1768
-
1777
.
Kung V, Broad J, Carroll R, Knowles C, Sanger G
(
2016
)
.
Effects of ageing on myenteric neuronal number and neuromuscular function in the human colon
.
The Lancet
.
vol.
387
,
Broad J, Takahashi N, Tajimi M, Sudo M, Góralczyk A, Parampalli U, Mannur K, Yamamoto T et al.
(
2015
)
.
RQ-00201894: A motilin receptor agonist causing long-lasting facilitation of human gastric cholinergically-mediated contractions
.
Journal of Pharmacological Sciences
vol.
130
,
(
2
)
60
-
65
.
Ng K, Chua Y, Gresty M, Marreddy U, Williams S, Barker G, Andrews P, Sanger G et al.
(
2010
)
.
OC-072 Identification of psychophysiological biomarkers of nausea using a novel visual induction method
.
Gut
.
vol.
59
,
Sanger GJ, Furness JB
(
2015
)
.
Ghrelin and motilin receptors as drug targets for gastrointestinal disorders
.
Nature Reviews Gastroenterology & Hepatology
vol.
13
,
(
1
)
38
-
48
.
Kung V, Broad J, Machesney M, THAHA MA, Knowles CH, Sanger G
(
2015
)
.
Preoperative chemotherapy does not appear to have short-term effects on human rectal neuromuscular functions
.
Gut
.
Conference:
Digestive Disorders Federation 2015
(
London, UK
)
from:
22/06/2015
to:
26/06/2015
,
vol.
Suppl 1
,
A584
-
A584
.
BENNETT A, JAROSIK C, SANGER GJ, WILSON DE
(
2015
)
.
ANTAGONISM OF PROSTANOID‐INDUCED CONTRACTIONS OF RAT GASTRIC FUNDUS MUSCLE BY SC‐19220, SODIUM MECLOFENAMATE, INDOMETHACIN OR TRIMETHOQUINOL
.
British Journal of Pharmacology
vol.
71
,
(
1
)
169
-
175
.
Cibert-Goton V, Kung VW, Hockley JR, Blackshaw A, Knowles CH, Sanger GJ, Bulmer DC
(
2015
)
.
Tu1873 Evidence for Reduced Visceral Nociceptors Activation With Age During Appendicitis
.
Gastroenterology
vol.
148
,
(
4
)
Broad J, Callaghan B, Sanger GJ, Brock JA, Furness JB
(
2015
)
.
Analysis of the ghrelin receptor-independent vascular actions of ulimorelin
.
European Journal of Pharmacology
vol.
752
,
34
-
39
.
Farmer AD, Ban VF, Coen SJ, Sanger GJ, Barker GJ, Gresty MA, Giampietro VP, Williams SC et al.
(
2015
)
.
Visually induced nausea causes characteristic changes in cerebral, autonomic and endocrine function in humans
.
The Journal of Physiology
vol.
593
,
(
5
)
1183
-
1196
.
Kung V, Broad J, Carroll R, Taylor F, Ahmed S, Knowles C, Sanger G
(
2015
)
.
Changes in human colon neuromuscular functions with age do not appear to be associated with changes in neuronal number in the myenteric plexus
.
NEUROGASTROENTEROLOGY AND MOTILITY
.
vol.
27
,
78
-
78
.
Kung V, Broad J, Machesney M, Thaha M, Knowles C, Sanger G
(
2015
)
.
Effects of long course preoperative chemo-radiotherapy on neuromuscular functions of the human rectum <i>ex vivo</i>
.
NEUROGASTROENTEROLOGY AND MOTILITY
.
vol.
27
,
78
-
78
.
Cibert-Goton V, Kung VW, Hockley JR, Blackshaw A, Knowles CH, Sanger GJ, Bulmer DC
(
2015
)
.
Evidence for Reduced Visceral Nociceptors Activation With Age During Appendicitis
.
GASTROENTEROLOGY
.
vol.
148
,
S924
-
S925
.
Parampalli U, Goralczyk A, Broad J, Sanger G, Devalia K, Mannur KR
(
2015
)
.
NEUROMUSCULAR ACTIVITY OF HUMAN ISOLATED STOMACH FROM OBESE PATIENTS IS NOT DEPENDENT ON AGE OR BMI STATUS
.
OBESITY SURGERY
.
vol.
25
,
S179
-
S180
.
Broad J, Hughes F, Chin-Aleong J, Sifrim D, Sanger GJ
(
2014
)
.
Regionally dependent neuromuscular functions of motilin and 5-HT₄ receptors in human isolated esophageal body and gastric fundus
.
Neurogastroenterol Motil
vol.
26
,
(
9
)
1311
-
1322
.
Broad J, Góralczyk A, Mannur K, Dukes GE, Sanger GJ
(
2014
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WARDLE KA, ELLIS ES, GASTER LM, KING FD, SANGER GJ
(
1993
)
.
SB-204070 - A HIGHLY POTENT AND SELECTIVE 5-HT4 RECEPTOR ANTAGONIST
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
110
,
P15
-
P15
.
BINGHAM S, KING BF, RUSHANT B, SMITH MI, SANGER GJ
(
1993
)
.
THE 5-HT4 RECEPTOR ANTAGONIST SB-204070 INHIBITS THE CONTRACTILE RESPONSE TO 5-HT IN THE DOG HEIDENHAIN POUCH
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
110
,
P16
-
P16
.
Bermudez J, King FD, Sanger GJ
(
1992
)
.
Indazole and indoline as aromatic bioisosteres in the imidazole class of serotonin 5-HT3 receptor antagonists
.
Bioorganic & Medicinal Chemistry Letters
vol.
2
,
(
12
)
1509
-
1512
.
BAXTER GS, BLACKBURN TP, SANGER GJ, WARDLE KA
(
1992
)
.
ACTIONS OF DAU 6285 AT PUTATIVE 5-HT4 RECEPTORS IN GUINEA-PIG COLON AND RAT ESOPHAGUS
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
106
,
P99
-
P99
.
KING BF, SANGER GJ
(
1992
)
.
FACILITATION OF NONCHOLINERGIC NEUROTRANSMISSION BY RENZAPRIDE (BRL-24924) IN CIRCULAR MUSCLE OF GUINEA-PIG ILEUM
.
BRITISH JOURNAL OF PHARMACOLOGY
.
vol.
107
,
P313
-
P313
.
Sanger GJ, Wardle KA, Shapcott S, Yee KF
(
1991
)
.
Constipation Evoked by 5-HT3 Receptor Antagonists
.
381
-
388
.
Sanger GJ
(
1990
)
.
New antiemetic drugs
.
Canadian Journal of Physiology and Pharmacology
.
vol.
68
,
314
-
324
.
Sanger GJ, Wardle KA
(
1990
)
.
5-Hydroxytryptamine and Cholinergic Function in the Gastrointestinal Tract
.
251
-
255
.
Bermudez J, Dunbar A, Sanger GJ, Turner DH
(
1990
)
.
Stimulation of canine gastric motility by BRL 24924, a new gastric prokinetic agent
.
Journal of Gastrointestinal Motility
vol.
2
,
(
4
)
281
-
286
.
SANGER GJ
(
1990
)
.
THE DEVELOPMENT OF SELECTIVE 5-HT3 RECEPTOR ANTAGONISTS AS ANTIEMETIC AGENTS
.
BRITISH JOURNAL OF CANCER
.
vol.
62
,
479
-
479
.
Wardle KA, Sanger GJ
(
1989
)
.
Atypical 5-HT receptors in guinea-pig isolated ileum
.
British Journal of Pharmacology
vol.
98 Suppl
,
King FD, Sanger GJ
(
1989
)
.
5-HT3 RECEPTOR ANTAGONISTS
.
Drugs of the Future
vol.
14
,
(
9
)
Sanger GJ, Nelson DR
(
1989
)
.
Selective and functional 5-hydroxytryptamine3 receptor antagonism by BRL 43694 (granisetron)
.
European Journal of Pharmacology
vol.
159
,
(
2
)
113
-
124
.
Sanger GJ, King FD
(
1988
)
.
From metoclopramide to selective gut motility stimulants and 5-HT3 receptor antagonists
.
Drug Design and Discovery
vol.
3
,
(
4
)
273
-
295
.
Bermudez J, Boyle E, Miner W, Sanger G
(
1988
)
.
The anti-emetic potential of the 5-hydroxytryptamine3 receptor antagonist BRL 43694
.
British Journal of Cancer
vol.
58
,
(
5
)
644
-
650
.
Andrews PLR, Rapeport WG, Sanger GJ
(
1988
)
.
Neuropharmacology of emesis induced by anti-cancer therapy
.
Trends in Pharmacological Sciences
vol.
9
,
(
9
)
334
-
341
.
King FD, Sanger GJ
(
1988
)
.
Chapter 21. Gastrointestinal Motility Enhancing Agents
.
Annual Reports in Medicinal Chemistry
vol.
23
,
201
-
210
.
BOYLE EA, MINER WD, SANGER GJ
(
1987
)
.
ANTIEMETIC ACTIVITY OF BRL43694, A NOVEL 5HT3-RECEPTOR ANTAGONIST
.
BRITISH JOURNAL OF CANCER
.
vol.
56
,
227
-
227
.
SANGER GJ
(
1987
)
.
Evidence that 5-hydroxytryptamine3 receptors mediate cytotoxic drug and radiation-evoked emesis
.
British Journal of Cancer
vol.
56
,
159
-
162
.
ANDREWS PLR, HAWTHORN J, SANGER GJ
(
1987
)
.
THE EFFECT OF ABDOMINAL VISCERAL NERVE LESIONS AND A NOVEL 5HT-M RECEPTOR ANTAGONIST ON CYTOTOXIC AND RADIATION-INDUCED EMESIS IN THE FERRET
.
JOURNAL OF PHYSIOLOGY-LONDON
.
vol.
382
,
P47
-
P47
.
Sanger GJ, McClelland CM
(
1986
)
.
Increased gastric cholinergic activity evoked by 5-hydroxy-L-tryptophan in the rat
.
European Journal of Pharmacology
vol.
127
,
(
3
)
179
-
185
.
SANGER GJ, Miner WD
(
1986
)
.
Inhibition of cisplatin-induced vomiting by selective 5-hydroxytryptamine M-receptor antagonism
.
British Journal of Pharmacology
vol.
88
,
497
-
499
.
Sanger GJ
(
1985
)
.
The effects of various pharmacological agents on the metoclopramide-induced increase in cholinergic-mediated contractions of rat isolated forestomach
.
European Journal of Pharmacology
vol.
114
,
(
2
)
139
-
145
.
McRitchie B, McClelland CM, Cooper SM, Turner DH, Sanger GJ
(
1984
)
.
Dopamine Antagonists as Anti-Emetics and as Stimulants of Gastric Motility
.
Mechanisms of Gastrointestinal Motility and Secretion
,
Springer Nature
MCCLELLAND CM, SANGER GJ
(
1984
)
.
METOCLOPRAMIDE (MCP) IS A POTENT STIMULANT OF CHOLINERGIC ACTIVITY IN RAT AND HUMAN ISOLATED STOMACH
.
GUT
.
vol.
25
,
1315
-
1315
.
Sanger GJ
(
1984
)
.
Mechanisms by which Metoclopramide can Increase Gastrointestinal Motility
.
Mechanisms of Gastrointestinal Motility and Secretion
,
Springer Nature
Bennett A, Sanger GJ
(
1984
)
.
Relationships of Prostaglandins to Gastrointestinal Motility and Secretion
.
Mechanisms of Gastrointestinal Motility and Secretion
,
Springer Nature
Sanger GJ, Bennett A
(
1984
)
.
Techniques for Studying Gastrointestinal Motility in Vitro
.
Mechanisms of Gastrointestinal Motility and Secretion
,
Springer Nature
Bennett A, Sanger GJ, Stamford IF, Hensby CN
(
1983
)
.
Prostanoids formed by human gastrointestinal tissues and their effects on muscle activity
.
Advances in Prostaglandin, Thromboxane, and Leukotriene Research
vol.
12
,
379
-
381
.
Sanger GJ, Jackson A, Bennett A
(
1982
)
.
A prostaglandin analogue which potently relaxes human uterus but not gut muscle
.
European Journal of Pharmacology
vol.
81
,
(
1
)
141
-
143
.
Bennet A, Hensby CN, Sanger GJ, Stamford IF
(
1981
)
.
Identification and Distribution of Arachidonic Acid Metabolites in the Human Gastrointestinal Tract, and the Ways in Which Some of these Affect the Longitudinal Muscle
.
The Prostaglandin System
,
Springer Nature
Sanger GJ, Bennett A
(
1981
)
.
Prostanoid Agonists and Antagonists: Differentiation of Prostanoid Receptors in the Gut
.
The Prostaglandin System
,
Springer Nature
Lacey SM, Sanger GJ
(
1980
)
.
Antagonism of prostanoid-induced contractions of rat stomach muscle by trimethoquinol or isoxsuprine
.
British Journal of Pharmacology
vol.
70
,
(
1
)
Sanger GJ, Bennett A
(
1980
)
.
PGI2 or PGE2 selectively antagonize responses to excitatory PGs in human isolated myometrium
.
Advances in Prostaglandin, Thromboxane, and Leukotriene Research
vol.
6
,
399
-
400
.
Bennett A, Sanger GJ
(
1980
)
.
Prostacyclin relaxes the longitudinal muscle of human isolated stomach and antagonizes contractions to some prostanoids [proceedings]
.
The Journal of Physiology
vol.
298
,
45p
-
46p
.
Sanger GJ, Bennett A
(
1980
)
.
Trimethoquinol selectively antagonizes contractions of rat gastric fundus to TXB2 and epoxymethano analogs of PGH2
.
Advances in Prostaglandin, Thromboxane, and Leukotriene Research
vol.
8
,
1559
-
1560
.
Bennett A, Sanger GJ
(
1979
)
.
Prostacyclin and prostaglandin E2 selectively antagonize responses of human isolated myometrium to excitatory prostaglandins [proceedings]
.
The Journal of Physiology
vol.
292
,
36p
-
37p
.
Bennett A, Carroll MA, Sanger GJ
(
1979
)
.
Sodium flufenamate antagonises the potentiation by prostaglandins of noradrenaline-induced vasoconstriction in rat mesentery [proceedings]
.
British Journal of Pharmacology
vol.
66
,
(
3
)
Bennett A, Sanger GJ
(
1979
)
.
Trimethoquinol selectively antagonises longitudinal muscle contractions of rat isolated gastric fundus to thromboxane B2 and epoxymethano analogues of PGH2 [proceedings]
.
British Journal of Pharmacology
vol.
66
,
(
3
)
Bennett A, Sanger GJ
(
1978
)
.
The effects of prostaglandin D2 on the circular muscle of guinea-pig isolated ileum and colon [proceedings]
.
British Journal of Pharmacology
vol.
63
,
(
2
)
357p
-
358p
.
Sanger GJ, Watt AJ
(
1976
)
.
A postsynaptic action of prostaglandin E1 on sympathetic responses in guinea-pig ileum [proceedings]
.
British Journal of Pharmacology
vol.
58
,
(
2
)
290p
-
291p
.
Blair EL, Grund ER, Reed JD, Sanders DJ, Sanger G, Shaw B
(
1975
)
.
The effect of sympathetic nerve stimulation on serum gastrin, gastric acid secretion and mucosal blood flow responses to meat extract stimulation in anaesthetized cats
.
The Journal of Physiology
vol.
253
,
(
2
)
493
-
504
.