Publications: Prof Gareth Sanger

Short E, Calimport S, Bentley B ( 2024 ) . Defining an ageing-related pathology, disease or syndrome: International Consensus Statement . GeroScience1 - 8 .

Kung VWS, Broad J, Makwana R, Palmer A, Baidoo N, Epton S, Elahi S, Chin‐Aleong J et al. ( 2024 ) . The impact of long‐course chemoradiotherapy on the myenteric plexus, neuromuscular functions and responses to prokinetic drugs in the human rectum . United European Gastroenterology Journal

Baidoo N, Sanger GJ ( 2024 ) . Age-related decline in goblet cell numbers and mucin content of the human colon: Implications for lower bowel functions in the elderly . Experimental and Molecular Pathology vol. 139 ,

Baidoo N, Sanger GJ ( 2024 ) . The human colon: Evidence for degenerative changes during aging and the physiological consequences . Neurogastroenterology & Motility

Oldroyd P, Oldroyd S, Meng M, Makwana R, Sanger G, Bulmer D, Malliaras GG, Owens RM ( 2024 ) . Stretchable Device for Simultaneous Measurements of Contractility and Electrophysiology of Neuromuscular Tissue in the Gastrointestinal Tract . Advanced Materials vol. 36 , ( 19 )

Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF et al. ( 2023 ) . The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors . British Journal of Pharmacology vol. 180 , ( S2 ) s23 - s144 .

Baidoo N, Sanger GJ, Belai A ( 2023 ) . Histochemical and biochemical analysis of collagen content in formalin-fixed, paraffin embedded colonic samples . MethodsX vol. 11 ,

Andrews PLR, Golding JF, Sanger GJ ( 2023 ) . An assessment of the effects of neurokinin1 receptor antagonism against nausea and vomiting: Relative efficacy, sites of action and lessons for future drug development . British Journal of Clinical Pharmacology vol. 89 , ( 12 ) 3468 - 3490 .

Makwana R, Sanger GJ ( 2023 ) . Characterization of rat gastric myogenic contractions and modulation by oxytocin and arginine-vasopressin . European Journal of Pharmacology vol. 955 ,

Davenport AP, Kitazawa T, Sanger G ( 2023 ) . Motilin receptor in GtoPdb v.2023.1 . IUPHAR/BPS Guide to Pharmacology CITE vol. 2023 , ( 1 )

Sanger GJ, Andrews PLR ( 2023 ) . Review article: An analysis of the pharmacological rationale for selecting drugs to inhibit vomiting or increase gastric emptying during treatment of gastroparesis . Alimentary Pharmacology & Therapeutics vol. 57 , ( 9 ) 962 - 978 .

Sanger GJ, Andrews PLR ( 2023 ) . Efficacy and Safety of Drugs for Gastroparesis: Dopamine Receptor Antagonists Should Not Be Considered as a Single Pharmacologic Entity . Gastroenterology vol. 165 , ( 2 ) 520 - 521 .

Perez-Ternero C, Aubdool A, Makwana R, Sanger G, Stimson R, Chan L, Moyes A, Hobbs A ( 2023 ) . C-type natriuretic peptide regulates metabolic homeostasis . JOURNAL OF TRANSLATIONAL MEDICINE . vol. 21 ,

Sanger GJ, Makwana R ( 2023 ) . Chapter 4A Commentary on The guts of the matter: Contribution of studies on smooth muscle to discoveries in pharmacology by Michael J. Rand and Frederick Mitchelson . Drug Action Haemodynamics and Immune Defence , Elsevier

Makwana R, Crawley E, Straface M, Gharibans A, Devalia K, Loy J, O'Grady G, Andrews PLR et al. ( 2023 ) . [Arg<SUP>8</SUP>]-vasopressin and adrenaline act in synergy to increase spontaneous myogenic contractile activity of human isolated stomach: Potential role in nausea . BRITISH JOURNAL OF PHARMACOLOGY . vol. 180 , 513 - 514 .

Varangot-Reille C, Sanger GJ, Andrews PLR, Herranz-Gomez A, Suso-Martí L, de la Nava J, Cuenca-Martínez F ( 2022 ) . Neural networks involved in nausea in adult humans: A systematic review . Autonomic Neuroscience vol. 245 ,

Andrews PLR, Williams RSB, Sanger GJ ( 2022 ) . Anti-emetic effects of thalidomide: Evidence, mechanism of action, and future directions . Current Research in Pharmacology and Drug Discovery vol. 3 ,

Baidoo N, Sanger GJ, Belai A ( 2022 ) . The vulnerability of the human taenia coli to alterations in total collagen within the colon of the elderly . Acta Histochemica vol. 124 , ( 8 )

Makwana R, Crawley E, Straface M, Palmer A, Gharibans A, Devalia K, Loy J, O'Grady G et al. ( 2022 ) . Synergistic augmentation of rhythmic myogenic contractions of human stomach by arginine vasopressin and adrenaline: Implications for the induction of nausea . British Journal of Pharmacology vol. 179 , ( 24 ) 5305 - 5322 .

Baidoo N, Sanger GJ, Belai A ( 2022 ) . Effect of old age on the subpopulations of enteric glial cells in human descending colon . Glia vol. 71 , ( 2 ) 305 - 316 .

Sanger GJ, Andrews PLR ( 2022 ) . A proposal for rational drug class terminology: A gastrointestinal perspective . British Journal of Pharmacology vol. 179 , ( 23 ) 5233 - 5234 .

Baidoo N, Crawley E, Knowles CH, Sanger GJ, Belai A ( 2022 ) . Total collagen content and distribution is increased in human colon during advancing age . PLOS ONE vol. 17 , ( 6 )

Straface M, Koussai M-A, Makwana R, Crawley E, Palmer A, Cai W, Gharibans A, Adebibe M et al. ( 2022 ) . A multi-parameter approach to measurement of spontaneous myogenic contractions in human stomach: Utilization to assess potential modulators of myogenic contractions . Pharmacological Research vol. 180 , Article 106247 , 106247 - 106247 .

Perez-Ternero C, Aubdool AA, Makwana R, Sanger GJ, Stimson RH, Chan LF, Moyes AJ, Hobbs AJ ( 2022 ) . C-type natriuretic peptide is a pivotal regulator of metabolic homeostasis . Proceedings of the National Academy of Sciences of the United States of America vol. 119 , ( 13 )

Sanger GJ ( 2022 ) . Why is motilin active in some studies with mice, rats, and guinea pigs, but not in others? Implications for functional variability among rodents . Pharmacology Research & Perspectives vol. 10 , ( 2 )

Sanger GJ, Andrews PLR ( 2022 ) . Emesis . Encyclopedia of Molecular Pharmacology , Springer Nature

Cai W, Makwana R, Straface M, Gharibans A, Andrews PLR, Sanger GJ ( 2021 ) . Evidence for tetrodotoxin‐resistant spontaneous myogenic contractions of mouse isolated stomach that are dependent on acetylcholine . British Journal of Pharmacology vol. 179 , ( 6 ) 1187 - 1200 .

Palmer A, Epton S, Crawley E, Straface M, Gammon L, Edgar MM, Xu Y, Elahi S et al. ( 2021 ) . Expression of p16 Within Myenteric Neurons of the Aged Colon: A Potential Marker of Declining Function . Frontiers in Neuroscience vol. 15 , 747067 - 747067 .

Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF et al. ( 2021 ) . THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors . British Journal of Pharmacology vol. 178 , ( S1 ) S27 - S156 .

Davenport AP, Kitazawa T, Sanger G ( 2021 ) . Motilin receptor in GtoPdb v.2021.2 . IUPHAR/BPS Guide to Pharmacology CITE vol. 2021 , ( 2 )

Barnes NM, Ahern GP, Becamel C, Bockaert J, Camilleri M, Chaumont-Dubel S, Claeysen S, Cunningham KA et al. ( 2020 ) . International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function . Pharmacological Reviews vol. 73 , ( 1 ) 310 - 520 .

Davis MP, Sanger GJ ( 2020 ) . The Benefits of Olanzapine in Palliating Symptoms . Current Treatment Options in Oncology vol. 22 , ( 1 )

Makwana R, Loy J, Adebibe M, Devalia K, Andrews PL, Sanger GJ ( 2020 ) . Copeptin, a surrogate marker of arginine8 vasopressin, has no ability to modulate human and mouse gastric motility . European Journal of Pharmacology vol. 892 ,

Andrews PLR, Cai W, Rudd JA, Sanger GJ ( 2020 ) . COVID‐19, nausea, and vomiting . Journal of Gastroenterology and Hepatology vol. 36 , ( 3 ) 646 - 656 .

Davenport AP, Sanger G ( 2020 ) . Motilin receptor (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database . IUPHAR/BPS Guide to Pharmacology CITE vol. 2020 , ( 4 )

Sanger G, Andrews P ( 2020 ) . Emesis . Encyclopedia of Molecular Pharmacology. , Editors: Offermanns, S, Rosenthal, W , In: Offermanns S., Rosenthal W. (eds) Encyclopedia of Molecular Pharmacology. Springer, Cham

Straface M, Makwana R, Palmer A, Rombolà L, Aleong JC, Morrone LA, Sanger GJ ( 2020 ) . Inhibition of Neuromuscular Contractions of Human and Rat Colon by Bergamot Essential Oil and Linalool: Evidence to Support a Therapeutic Action . Nutrients vol. 12 , ( 5 )

Choudhry N, Scott F, Edgar M, Sanger GJ, Kelly P ( 2020 ) . Reversal of Pathogen-Induced Barrier Defects in Intestinal Epithelial Cells by Contra-pathogenicity Agents . Digestive Diseases and Sciences

Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF et al. ( 2019 ) . THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors . British Journal of Pharmacology vol. 176 , ( S1 ) S21 - S141 .

Cibert-Goton V, Kung VWS, McGuire C, Hockley JRF, Tranter MM, Dogra H, Belai A, Blackshaw LA et al. ( 2019 ) . Functional and anatomical deficits in visceral nociception with age: a mechanism of silent appendicitis in the elderly? . Pain vol. 161 , ( 4 ) 773 - 786 .

Straface M, Makwana R, Rombola L, Chinaleong J, Morrone LA, Sanger GJ ( 2019 ) . Bergamot essential oil and its constituent linalool, inhibit cholinergically-mediated contractions of human and rat isolated colon . NEUROGASTROENTEROLOGY AND MOTILITY . Conference: Neurogastroenterology vol. 31 ,

Palmer A, Straface M, Chin-Aleong J, Knowles C, Sanger GJ ( 2019 ) . Isolation and culture of primary myenteric neurons and glial cells from human colon: The effects of different concentrations of nerve growth factor . NEUROGASTROENTEROLOGY AND MOTILITY . Conference: Neurogastroenterology vol. 31 ,

Makwana R, Elahi S, Adebibe M, Loy J, Sanger GJ ( 2019 ) . Low concentrations of arginine vasopressin (AVP) act at V1A receptors in human stomach to increase frequency and amplitude of spontaneous rhythmic contractions: Role in nausea . NEUROGASTROENTEROLOGY AND MOTILITY . Conference: Neurogastroenterology ( Lisbon, Portugal ) from: 05/09/2019 to: 07/09/2019 , vol. 31 ,

Sanger GJ, Andrews PL ( 2019 ) . Emesis . Drug Therapy for Gastrointestinal and Liver Diseases , Taylor & Francis

Scott F, Elahi S, Adebibe M, Parampalli U, Mannur K, Góralczyk A, Sanger GJ ( 2019 ) . Farnesoid X receptor ‐ a molecular predictor of weight loss after vertical sleeve gastrectomy? . Obesity Science & Practice vol. 5 , ( 3 ) 273 - 280 .

Ruffle JK, Patel A, Giampietro V, Howard MA, Sanger GJ, Andrews PLR, Williams SCR, Aziz Q et al. ( 2019 ) . Functional brain networks and neuroanatomy underpinning nausea severity can predict nausea susceptibility using machine learning . The Journal of Physiology vol. 597 , ( 6 ) 1517 - 1529 .

Palmer A, Chng S-H, Chin-Aleong J, Knowles C, Pachnis V, Sanger G ( 2019 ) . Differentiation of neurons from cultured human primary enteric glial cells . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 31 ,

Makwana R, Kouassi M, Elahi S, Adebibe M, Loy J, Sanger G ( 2019 ) . Increased frequency and amplitude of spontaneous contractions in human stomach by vasopressin acting at V_1A receptors in low concentrations found in plasma during nausea . BRITISH JOURNAL OF PHARMACOLOGY . vol. 176 , 3053 - 3054 .

SANGER GJ, BROAD J, KUNG V, Palmer A, ELAHI S, Karami A, Darreh-Shori T, Ahmed S et al. ( 2018 ) . Changes in neuromuscular structure and functions of human colon during ageing are region-dependent . Gut

SANGER GJ, Andrews PLR ( 2018 ) . A History of Drug Discovery for Treatment of Nausea and Vomiting and the Implications for Future Research . Front. Pharmacol. 9:913. vol. 9 , Article 913 ,

Kouassi M-A, Palmer A, Elahi S, Loy J, Goralczyk A, Adebibe M, Novak P, Sanger G ( 2018 ) . Interstitial cells of Cajal: Translation of mechanisms regulating function to the human stomach . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 30 ,

Palmer A, Elahi S, Edgar M, Chin-Aleong J, Knowles C, Sanger G ( 2018 ) . Isolation and culture of human primary neurons and glial cells from the myenteric plexus of the colon for structural, molecular and functional studies . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 30 ,

Alexander SPH, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL et al. ( 2017 ) . THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview . British Journal of Pharmacology vol. 174 , S1 - S16 .

Sanger GJ ( 2017 ) . Actions of Drugs in the Gastrointestinal Tract . Pharmacology for Chemists: Drug Discovery in Context , Royal Society of Chemistry (RSC)

Alexander SP, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ et al. ( 2017 ) . THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Enzymes . British Journal of Pharmacology vol. 174 , ( Suppl Suppl 1 ) s272 - s359 .

Palmer A, Ahmed S, Thaha MA, Knowles C, Sanger G ( 2017 ) . Isolation of myenteric neurons from adult human colon, to investigate changes during advanced age and degenerative disorders . NEUROGASTROENTEROLOGY AND MOTILITY . Editors: Galligan, J, Bredenoord, A, Vanner, S , Conference: Neuro Gastro 2017 ( Cork, Ireland ) from: 24/08/2017 to: 26/08/2017 , vol. 29 , 96 - 96 .

Liszt KI, Ley JP, Lieder B, Behrens M, Stöger V, Reiner A, Hochkogler CM, Köck E et al. ( 2017 ) . Caffeine induces gastric acid secretion via bitter taste signaling in gastric parietal cells . Proceedings of the National Academy of Sciences vol. 114 , ( 30 ) E6260 - E6269 .

Sanger GJ, Pasricha PJ ( 2017 ) . Investigational drug therapies for the treatment of gastroparesis . Expert Opin Investig Drugs vol. 26 , ( 3 ) 331 - 342 .

Kouassi M-A, Palmer A, Broad J, Scott F, Elahi S, Goralczyk A, Adebibe M, Mannur K et al. ( 2017 ) . Inhibition of human gastric dysrhythmia by sildenafil, not by Ano1 inhibitors . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 29 , 115 - 115 .

Scott F, Kouassi M-A, Warnes G, Hornsby E, Elahi S, Adedibe M, Goralczyk A, Mannur K et al. ( 2017 ) . Isolation of human gastric interstitial cells of Cajal . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 29 , 127 - 127 .

Palmer A, Broad J, Elahi S, Scott F, Knowles C, Sanger G ( 2017 ) . The effects of ageing on gene expression in the human colon . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 29 , 96 - 96 .

Broad J, Scott F, Palmer A, Kung V, Kouassi M-A, Elahi S, Knowles C, Sanger G ( 2017 ) . The effects of the active metabolites of sodium picosulfate and senna on human colorectal neuromuscular activity . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 29 , 95 - 95 .

Sanger GJ, Broad J, Callaghan B, Furness JB ( 2016 ) . Ghrelin and Motilin Control Systems in GI Physiology and Therapeutics . vol. 239 , SpringerLink

McGuire C, Boundouki G, Hockley JR, Reed D, Cibert-Goton V, Peiris M, Kung V, Broad J et al. ( 2016 ) . Ex vivo study of human visceral nociceptors . GUT Article 27654583 , 1 - 11 .

Broad J, Maurel D, Kung VWS, Hicks GA, Schemann M, Barnes MR, Kenakin TP, Granier S et al. ( 2016 ) . Human native kappa opioid receptor functions not predicted by recombinant receptors: Implications for drug design . Scientific Reports vol. 6 , ( 1 )

Sanger GJ ( 2016 ) . Chronic constipation: improved understanding offers a new therapeutic approach . J Physiol vol. 594 , ( 15 ) 4085 - 4087 .

Broad J, Kung V, Karami A, Darreh-Shori T, Knowles C, Sanger GJ ( 2016 ) . Region-specific increase in colonic function of choline acetyltransferase in the elderly . NEUROGASTROENTEROLOGY AND MOTILITY . Conference: Neurogastro Motility vol. 28 , 102 - 102 .

Sanger GJ, Twycross R ( 2016 ) . Making Sense of Emesis, Pruritus, 5-HT and 5-HT3 Receptor Antagonists . Progress in Palliative Care vol. 4 , ( 1 ) 7 - 8 .

Hellström PM, Tack J, Johnson LV, Hacquoil K, Barton ME, Richards DB, Alpers DH, Sanger GJ et al. ( 2016 ) . The pharmacodynamics, safety and pharmacokinetics of single doses of the motilin agonist, camicinal, in type 1 diabetes mellitus with slow gastric emptying . British Journal of Pharmacology vol. 173 , ( 11 ) 1768 - 1777 .

Kung V, Broad J, Carroll R, Knowles C, Sanger G ( 2016 ) . Effects of ageing on myenteric neuronal number and neuromuscular function in the human colon . The Lancet . vol. 387 ,

Broad J, Takahashi N, Tajimi M, Sudo M, Góralczyk A, Parampalli U, Mannur K, Yamamoto T et al. ( 2015 ) . RQ-00201894: A motilin receptor agonist causing long-lasting facilitation of human gastric cholinergically-mediated contractions . Journal of Pharmacological Sciences vol. 130 , ( 2 ) 60 - 65 .

Ng K, Chua Y, Gresty M, Marreddy U, Williams S, Barker G, Andrews P, Sanger G et al. ( 2010 ) . OC-072 Identification of psychophysiological biomarkers of nausea using a novel visual induction method . Gut . vol. 59 ,

Sanger GJ, Furness JB ( 2015 ) . Ghrelin and motilin receptors as drug targets for gastrointestinal disorders . Nature Reviews Gastroenterology & Hepatology vol. 13 , ( 1 ) 38 - 48 .

Kung V, Broad J, Machesney M, THAHA MA, Knowles CH, Sanger G ( 2015 ) . Preoperative chemotherapy does not appear to have short-term effects on human rectal neuromuscular functions . Gut . Conference: Digestive Disorders Federation 2015 ( London, UK ) from: 22/06/2015 to: 26/06/2015 , vol. Suppl 1 , A584 - A584 .

BENNETT A, JAROSIK C, SANGER GJ, WILSON DE ( 2015 ) . ANTAGONISM OF PROSTANOID‐INDUCED CONTRACTIONS OF RAT GASTRIC FUNDUS MUSCLE BY SC‐19220, SODIUM MECLOFENAMATE, INDOMETHACIN OR TRIMETHOQUINOL . British Journal of Pharmacology vol. 71 , ( 1 ) 169 - 175 .

Cibert-Goton V, Kung VW, Hockley JR, Blackshaw A, Knowles CH, Sanger GJ, Bulmer DC ( 2015 ) . Tu1873 Evidence for Reduced Visceral Nociceptors Activation With Age During Appendicitis . Gastroenterology vol. 148 , ( 4 )

Broad J, Callaghan B, Sanger GJ, Brock JA, Furness JB ( 2015 ) . Analysis of the ghrelin receptor-independent vascular actions of ulimorelin . European Journal of Pharmacology vol. 752 , 34 - 39 .

Farmer AD, Ban VF, Coen SJ, Sanger GJ, Barker GJ, Gresty MA, Giampietro VP, Williams SC et al. ( 2015 ) . Visually induced nausea causes characteristic changes in cerebral, autonomic and endocrine function in humans . The Journal of Physiology vol. 593 , ( 5 ) 1183 - 1196 .

Kung V, Broad J, Carroll R, Taylor F, Ahmed S, Knowles C, Sanger G ( 2015 ) . Changes in human colon neuromuscular functions with age do not appear to be associated with changes in neuronal number in the myenteric plexus . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 27 , 78 - 78 .

Kung V, Broad J, Machesney M, Thaha M, Knowles C, Sanger G ( 2015 ) . Effects of long course preoperative chemo-radiotherapy on neuromuscular functions of the human rectum <i>ex vivo</i> . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 27 , 78 - 78 .

Cibert-Goton V, Kung VW, Hockley JR, Blackshaw A, Knowles CH, Sanger GJ, Bulmer DC ( 2015 ) . Evidence for Reduced Visceral Nociceptors Activation With Age During Appendicitis . GASTROENTEROLOGY . vol. 148 , S924 - S925 .

Parampalli U, Goralczyk A, Broad J, Sanger G, Devalia K, Mannur KR ( 2015 ) . NEUROMUSCULAR ACTIVITY OF HUMAN ISOLATED STOMACH FROM OBESE PATIENTS IS NOT DEPENDENT ON AGE OR BMI STATUS . OBESITY SURGERY . vol. 25 , S179 - S180 .

Broad J, Hughes F, Chin-Aleong J, Sifrim D, Sanger GJ ( 2014 ) . Regionally dependent neuromuscular functions of motilin and 5-HT₄ receptors in human isolated esophageal body and gastric fundus . Neurogastroenterol Motil vol. 26 , ( 9 ) 1311 - 1322 .

Broad J, Góralczyk A, Mannur K, Dukes GE, Sanger GJ ( 2014 ) . Drugs acting at 5-HT4 , D2 , motilin, and ghrelin receptors differ markedly in how they affect neuromuscular functions in human isolated stomach . Neurogastroenterol Motil vol. 26 , ( 6 ) 851 - 861 .

Broad J, Kung VW, Greene-Diniz R, Knowles CH, Sanger GJ ( 2014 ) . Sa2043 Regionally-Specific Changes in Human Colonic Neuromuscular Activity With Advanced Age . Gastroenterology vol. 146 , ( 5 ) s - 362 .

Farmer AD, Ban VF, Sanger GJ, Coen SJ, Andrews P, Azi Q ( 2014 ) . Tu1811 Cortical & Physiological Responses to Visually Induced Motion Sickness . Gastroenterology vol. 146 , ( 5 ) s - 850 .

Sanger GJ ( 2014 ) . The relationship between symptom improvement and gastric emptying in the treatment of gastroparesis: remember the pharmacology . Am J Gastroenterol vol. 109 , ( 3 ) 444 - 445 .

Sanger GJ ( 2014 ) . Ghrelin and motilin receptor agonists: time to introduce bias into drug design . Neurogastroenterol Motil vol. 26 , ( 2 ) 149 - 155 .

Andrews PLR, Sanger GJ ( 2014 ) . Nausea and the quest for the perfect anti-emetic . Eur J Pharmacol vol. 722 , 108 - 121 .

Kung V, Broad J, Knowles C, Sanger G ( 2014 ) . Age related changes of neuromuscular functions in the human ascending colon . NEUROGASTROENTEROLOGY AND MOTILITY vol. 26 , 34 - 34 .

Farmer AD, Ban VF, Sanger GJ, Coen SJ, Andrews P, Aziz Q ( 2014 ) . Cortical & Physiological Responses to Visually Induced Motion Sickness . GASTROENTEROLOGY . vol. 146 , S850 - S850 .

Kung VWS, Broad J, Sanger GJ, Knowles CH ( 2014 ) . Gender- and regionally-specific decline in colonic neuromuscular activity with advanced age . BRITISH JOURNAL OF SURGERY . vol. 101 , 3 - 3 .

Andrews PLR, Sanger GJ ( 2014 ) . Nausea and the quest for the perfect anti-emetic . EUROPEAN JOURNAL OF PHARMACOLOGY vol. 722 , 108 - 121 .

Broad J, Kung VW, Greene-Diniz R, Knowles CH, Sanger GJ ( 2014 ) . Regionally-Specific Changes in Human Colonic Neuromuscular Activity With Advanced Age . GASTROENTEROLOGY . vol. 146 , S362 - S362 .

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M et al. ( 2013 ) . The Concise Guide to PHARMACOLOGY 2013/14: Overview . British Journal of Pharmacology vol. 170 , ( 8 ) 1449 - 1458 .

Sanger GJ ( 2013 ) . Ghrelin and motilin receptor agonists: a long and winding misconception . Neurogastroenterol Motil vol. 25 , ( 12 )

Sanger GJ, Wang Y, Hobson A, Broad J ( 2013 ) . Motilin: towards a new understanding of the gastrointestinal neuropharmacology and therapeutic use of motilin receptor agonists . Br J Pharmacol vol. 170 , ( 7 ) 1323 - 1332 .

Broad J, Kung VWS, Boundouki G, Aziz Q, De Maeyer JH, Knowles CH, Sanger GJ ( 2013 ) . Cholinergic interactions between donepezil and prucalopride in human colon: potential to treat severe intestinal dysmotility . Br J Pharmacol vol. 170 , ( 6 ) 1253 - 1261 .

Sanger GJ, Broad J, Andrews PLR ( 2013 ) . The relationship between gastric motility and nausea: gastric prokinetic agents as treatments . Eur J Pharmacol vol. 715 , ( 1-3 ) 10 - 14 .

Ng KS, Chua YC, Ban VF, Gresty M, Gampietro V, Coen SJ, Sanger GJ, Fitch KE et al. ( 2013 ) . Su2110 Brain Processing of Visual Motion Induced Nausea in Healthy Humans . Gastroenterology vol. 144 , ( 5 )

Broad J, Sanger GJ ( 2013 ) . The antibiotic azithromycin is a motilin receptor agonist in human stomach: comparison with erythromycin . Br J Pharmacol vol. 168 , ( 8 ) 1859 - 1867 .

Javid FA, Bulmer DC, Broad J, Aziz Q, Dukes GE, Sanger GJ ( 2013 ) . Anti-emetic and emetic effects of erythromycin in Suncus murinus: role of vagal nerve activation, gastric motility stimulation and motilin receptors . Eur J Pharmacol vol. 699 , ( 1-3 ) 48 - 54 .

Ng KS, Chua YC, Ban VF, Gresty M, Gampietro V, Coen SJ, Sanger GJ, Fitch KE et al. ( 2013 ) . Brain Processing of Visual Motion Induced Nausea in Healthy Humans . GASTROENTEROLOGY . vol. 144 , S560 - S561 .

Izzo AA ( 2013 ) . Novel insights which may translate into treatments for irritable bowel syndrome . Frontiers in Pharmacology vol. 4 ,

Sanger GJ, Broad J, Kung V, Knowles CH ( 2013 ) . Translational neuropharmacology: the use of human isolated gastrointestinal tissues . Br J Pharmacol vol. 168 , ( 1 ) 28 - 43 .

Sanger GJ ( 2012 ) . Motilin receptor neuropharmacology: revised understanding . Curr Opin Pharmacol vol. 12 , ( 6 ) 641 - 646 .

Sanger GJ ( 2012 ) . New target profiling for gastrointestinal disorders: where are we going? . Curr Opin Pharmacol vol. 12 , ( 6 ) 629 - 631 .

Webb D-L, Rudholm-Feldreich T, Gillberg L, Halim MA, Theodorsson E, Sanger GJ, Campbell CA, Boyce M et al. ( 2012 ) . The type 2 CCK/gastrin receptor antagonist YF476 acutely prevents NSAID-induced gastric ulceration while increasing iNOS expression . Naunyn-Schmiedeberg's Archives of Pharmacology vol. 386 , ( 1 ) 41 - 49 .

Broad J, Mukherjee S, Samadi M, Martin JE, Dukes GE, Sanger GJ ( 2012 ) . Regional- and agonist-dependent facilitation of human neurogastrointestinal functions by motilin receptor agonists . Br J Pharmacol vol. 167 , ( 4 ) 763 - 774 .

Burke T, Sanger G ( 2012 ) . Regionally selective cholinergic stimulation by BRL 24924 in the human isolated gut . British Journal of Clinical Pharmacology vol. 26 , ( 3 ) 261 - 265 .

BENNETT A, PRATT D, SANGER GJ ( 2012 ) . ANTAGONISM BY FENAMATES OF PROSTAGLANDIN ACTION IN GUINEA‐PIG AND HUMAN ALIMENTARY MUSCLE . British Journal of Pharmacology vol. 68 , ( 3 ) 357 - 362 .

Banner SE, Sanger GJ ( 2012 ) . Differences between 5‐HT3 receptor antagonists in modulation of visceral hypersensitivity . British Journal of Pharmacology vol. 114 , ( 2 ) 558 - 562 .

Sanger GJ ( 2012 ) . Increased gut cholinergic activity and antagonism of 5‐hydroxytryptamine M‐receptors by BRL 24924: potential clinical importance of BRL 24924 . British Journal of Pharmacology vol. 91 , ( 1 ) 77 - 87 .

BENNETT A, HENSBY CN, SANGER GJ, STAMFORD IF ( 2012 ) . METABOLITES OF ARACHIDONIC ACID FORMED BY HUMAN GASTROINTESTINAL TISSUES AND THEIR ACTIONS ON THE MUSCLE LAYERS . British Journal of Pharmacology vol. 74 , ( 2 ) 435 - 444 .

BENNETT A, SANGER GJ ( 2012 ) . PINANE THROMBOXANE A2 ANALOGUES ARE NON‐SELECTIVE PROSTANOID ANTAGONISTS IN RAT AND HUMAN STOMACH MUSCLE . British Journal of Pharmacology vol. 77 , ( 4 ) 591 - 596 .

Wardle KA, Bingham S, Ellis ES, Gaster LM, Rushant B, Smith MI, Sanger GJ ( 2012 ) . Selective and functional 5‐hydroxytryptamine4 receptor antagonism by SB 207266 . British Journal of Pharmacology vol. 118 , ( 3 ) 665 - 670 .

Wardle KA, Ellis ES, Baxter GS, Kennett GA, Gaster LM, Sanger GJ ( 2012 ) . The effects of SB 204070, a highly potent and selective 5‐HT4 receptor antagonist, on guinea‐pig distal colon . British Journal of Pharmacology vol. 112 , ( 3 ) 789 - 794 .

Moss HE, Sanger GJ ( 2012 ) . The effects of granisetron, ICS 205–930 and ondansetron on the visceral pain reflex induced by duodenal distension . British Journal of Pharmacology vol. 100 , ( 3 ) 497 - 501 .

Wardle KA, Sanger GJ ( 2012 ) . The guinea‐pig distal colon ‐ a sensitive preparation for the investigation of 5‐HT4 receptor‐mediated contractions . British Journal of Pharmacology vol. 110 , ( 4 ) 1593 - 1599 .

Sanger GJ, Bennett A ( 2012 ) . Fenamates may antagonize the actions of prostaglandin endoperoxides in human myometrium . British Journal of Clinical Pharmacology vol. 8 , ( 5 ) 479 - 482 .

Sung EZ, Arasaradnam RP, Jarvie EM, James S, Goodyear SJ, Borman RA, Snead D, SANGER GJ et al. ( 2012 ) . Effects of neo-adjuvant chemotherapy for oesophago-gastric cancer on neuro-muscular gastric function . Mol Biol Rep vol. 39 , ( 12 ) 9989 - 9994 .

Ng KS, Chua YC, Ban VF, Gresty M, Coen SJ, Sanger GJ, Williams SC, Barker G et al. ( 2012 ) . 490 Studies of the Psychophysiological Markers and the Brain Processing of Nausea in Healthy Humans Using a Novel Virtual Reality Video . Gastroenterology vol. 142 , ( 5 ) s - 105 .

Broad J, Goralczyk A, Dukes G, Sanger G ( 2012 ) . Facilitation of cholinergic activity in human isolated stomach by metoclopramide and by the selective motilin receptor agonist GSK962040, but not by domperidone . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 24 , 59 - 59 .

Ng KS, Andrews P, Chua YC, Ban VF, Gresty M, Coen SJ, Sanger GJ, Williams SC et al. ( 2012 ) . Psychophysiological markers and the brain processing of nausea in healthy humans using a novel virtual reality video . NEUROGASTROENTEROLOGY AND MOTILITY vol. 24 , 39 - 40 .

Ng KS, Coen SJ, Chua YC, Ban VF, Gresty MA, Sanger GJ, Williams SC, Barker GJ et al. ( 2012 ) . STUDIES OF THE PSYCHOPHYSIOLOGICAL MARKERS AND THE BRAIN PROCESSING OF NAUSEA IN HEALTHY HUMANS USING A NOVEL VIRTUAL REALITY VIDEO . GUT vol. 61 , A317 - A318 .

Ng KS, Chua YC, Ban VF, Gresty M, Coen SJ, Sanger GJ, Williams SC, Barker G et al. ( 2012 ) . Studies of the Psychophysiological Markers and the Brain Processing of Nausea in Healthy Humans Using a Novel Virtual Reality Video . GASTROENTEROLOGY . vol. 142 , S105 - S105 .

Broad J, Andrews PL, Sanger GJ ( 2012 ) . VASOPRESSIN CONTRACTS HUMAN ISOLATED STOMACH MUSCLE: POSSIBLE ROLE IN NAUSEA? . GUT vol. 61 , A297 - A298 .

Leming S, Broad J, Cozens SJ, Otterson M, Winchester W, Lee K, Dukes GE, Sanger GJ ( 2011 ) . GSK962040: a small molecule motilin receptor agonist which increases gastrointestinal motility in conscious dogs . Neurogastroenterol Motil vol. 23 , ( 10 ) 958 - e410 .

Sanger GJ, Holbrook JD, Andrews PLR ( 2011 ) . The translational value of rodent gastrointestinal functions: a cautionary tale . Trends Pharmacol Sci vol. 32 , ( 7 ) 402 - 409 .

Martin JE, Chowdhury AH, McElwaine S, Fikree A, Broad J, Knowles CH, Allen L, Bevan S et al. ( 2011 ) . A Novel Phenotype of Glycogen Storage Disease Presenting as Gastrointestinal Neuromuscular Disease . Gastroenterology vol. 140 , ( 5 ) s - 705 .

Hellström PM, Rudholm T, Gillberg L, Theodorsson E, Webb D, Sanger GJ, Naslund E ( 2011 ) . Gastrin Receptor Antagonist YF476: Effects on Gastric Acid Secretion, Regulatory Peptides and Receptor Gene Expression in Rats . Gastroenterology vol. 140 , ( 5 ) s - 730 .

Ng KS, Chua YC, Ban VF, Gresty M, Coen SJ, Sanger GJ, Williams SC, Barker G et al. ( 2011 ) . Identifying Human Biomarkers of Nausea for Refining Animal Studies on Emesis . Gastroenterology vol. 140 , ( 5 ) s - 368 .

Broad J, Mukerjee S, Boundouki G, Hughes F, Mannur KR, Knowles CH, Dukes GE, Sanger GJ ( 2011 ) . Regionally-Dependent Responses to Both Nerve Stimulation and to Motilin in Human Isolated Esophagus, Stomach, Small and Large Intestine . Gastroenterology . vol. 140 ,

Broad J, Hubball A, Souza M, Boundouki G, Knowles CH, Sanger GJ ( 2011 ) . Serum but Not IgG From Patients With Chagas' Disease Relax Naive Human Colon Muscle Without Directly Interfering With Motor Nerve Functions . Gastroenterology vol. 140 , ( 5 ) s - 282 .

Ng K, Chua Y, Ban VF, Gresty M, Coen S, Sanger G, Williams S, Barker G et al. ( 2011 ) . Identifying human biomarkers of nausea for refining animal studies on emesis . Gut . vol. 60 ,

Martin JE, Chowdhury AH, McElwaine S, Fikree A, Broad J, Knowles CH, Allen L, Bevan S et al. ( 2011 ) . A Novel Phenotype of Glycogen Storage Disease Presenting as Gastrointestinal Neuromuscular Disease . GASTROENTEROLOGY . vol. 140 , S705 - S705 .

Hellstrom PM, Rudholm T, Gillberg L, Theodorsson E, Webb D, Sanger GJ, Naslund E ( 2011 ) . Gastrin Receptor Antagonist YF476: Effects on Gastric Acid Secretion, Regulatory Peptides and Receptor Gene Expression in Rats . GASTROENTEROLOGY . vol. 140 , S730 - S730 .

Ng KS, Chua YC, Ban VF, Gresty M, Coen SJ, Sanger GJ, Williams SC, Barker G et al. ( 2011 ) . Identifying Human Biomarkers of Nausea for Refining Animal Studies on Emesis . GASTROENTEROLOGY . vol. 140 , S368 - S368 .

Broad J, Hubball A, Souza M, Boundouki G, Knowles CH, Sanger GJ ( 2011 ) . Serum but Not IgG From Patients With Chagas' Disease Relax Naive Human Colon Muscle Without Directly Interfering With Motor Nerve Functions . GASTROENTEROLOGY . vol. 140 , S282 - S282 .

Sanger GJ, Broad J, Alpers DH ( 2011 ) . Translation of Motilin and Ghrelin Receptor Agonists into Drugs for Gastrointestinal Disorders . Peptide Drug Discovery and Development. Translational Research in Academia and Industry , Editors: Castanho, MARB, Santos, NC , Wiley VCH

Sanger GJ, Quigley EMM ( 2010 ) . Constipation, IBs and the 5-HT4 Receptor: What Role for Prucalopride? . Therapeutic Advances in Gastrointestinal Endoscopy vol. 3 ,

SANGER GJ ( 2010 ) . 5‐Hydroxytryptamine and functional bowel disorders . Neurogastroenterology & Motility vol. 8 , ( 4 ) 319 - 331 .

Sanger GJ, Chang L, Bountra C, Houghton LA ( 2010 ) . Challenges and prospects for pharmacotherapy in functional gastrointestinal disorders . Therap Adv Gastroenterol vol. 3 , ( 5 ) 291 - 305 .

GASTER LM, JOINER GF, KING FD, WYMAN PA, SUTTON JM, BINGHAM S, ELLIS ES, SANGER GJ et al. ( 2010 ) . ChemInform Abstract: N‐((1‐Butyl‐4‐piperidinyl)methyl)‐3,4‐dihydro‐2H‐(1,3)oxazino(3,2‐a) indole‐10‐carboxamide Hydrochloride: The First Potent and Selective 5‐ HT4 Receptor Antagonist Amide with Oral Activity . ChemInform vol. 27 , ( 14 ) no - no .

Falken Y, Hellstrom PM, Sanger GJ, Dewit O, Dukes G, Gryback P, Holst JJ, Naslund E ( 2010 ) . Actions of prolonged ghrelin infusion on gastrointestinal transit and glucose homeostasis in humans . NEUROGASTROENT MOTIL vol. 22 , ( 6 ) e192 - e200 .

Ng KS, Chua YC, Gresty M, Marreddy U, Williams SC, Barker G, Andrews P, Sanger GJ et al. ( 2010 ) . M2052 Identification of Psychophysiological Biomarkers of Nausea Using a Novel Visual Induction Method . Gastroenterology vol. 138 , ( 5 ) s - 467 .

Broad J, Boundouki G, Knowles CH, Sanger GJ ( 2010 ) . CHARACTERISATION OF MOTOR NERVE RESPONSES TO ELECTRICAL FIELD STIMULATION IN HUMAN ISOLATED COLON . GUT . vol. 59 , A140 - A140 .

Sanger GJ, Chang L, Bountra C, Houghton L ( 2010 ) . Challenges and Prospects for Pharmacotherapy in Functional Gastrointestinal Disorders . Ther Adv Gastroenterol vol. 3 , ( 5 ) 291 - 305 .

Broad J, Mukherjee S, Boundouki G, Dukes GE, Sanger GJ ( 2010 ) . Different abilities of [Nle13]-motilin and the motilin receptor agonist GSK962040 to facilitate cholinergic and nitrergic activity in human isolated stomach . Neurogastroenterol Motil . vol. 22 (S1) ,

Westaway SM, Sanger GJ, Dukes G ( 2010 ) . From discovery to clinic: GSK962040, the first oral, small molecule motilin receptor agonist for treatment of conditions associated with impaired gastric motility . ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY . vol. 240 ,

Ferens DM, Yin L, Bron R, Hunne B, Ohashi-Doi K, Kitchener PD, Sanger GJ, Witherington J et al. ( 2010 ) . Functional and in situ hybridisation evidence that preganglionic sympathetic vasoconstrictor neurons express ghrelin receptors . Neuroscience vol. 166 , ( 2 ) 671 - 679 .

Broad J, Leming S, Matthews KL, Briggs M, Otterson M, Winchester W, Cozens SJ, Dukes GE et al. ( 2010 ) . GSK962040: a small molecule motilin receptor agonist which increases gastrointestinal (GI) motility in dogs . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 22 , 84 - 84 .

Broad J, Leming S, Matthews KL, Briggs M, Otterson M, Winchester W, Cozens SJ, Dukes GE et al. ( 2010 ) . GSK962040: a small molecule motilin receptor agonist which increases gastrointestinal (GI) motility in dogs . Neurogastroenterol Motil . vol. 23 , 958 - e410 .

Sanger GJ ( 2010 ) . Gastrointestinal pharmacology: challenges ahead . Front Pharm vol. 1 , 4 - 4 .

Ng KS, Chua YC, Gresty M, Marreddy U, Williams SC, Barker G, Andrews P, Sanger GJ et al. ( 2010 ) . Identification of Psychophysiological Biomarkers of Nausea Using a Novel Visual Induction Method . GASTROENTEROLOGY . vol. 138 , S467 - S467 .

Ng K, Chua Y, Gresty M, Marreddy U, Williams S, Barker G, Andrews P, Sanger G et al. ( 2010 ) . Identification of psychophysiological biomarkers of nausea using a novel visual induction method . Gut . vol. 59 suppl 1 ,

Sanger GJ, Hellström PM, Näslund E ( 2010 ) . The hungry stomach: physiology, disease, and drug development opportunities . Front Pharmacol vol. 1 ,

Medhurst A, Lawson S, Raval P, Sanger G, Newton R, Parsons A, Davey P, Bingham S et al. ( 2009 ) . Molecular Approaches to the Study of Pain . Pain , Taylor & Francis

Sanger GJ ( 2009 ) . Translating 5-HT receptor pharmacology . Neurogastroenterol Motil vol. 21 , ( 12 ) 1235 - 1238 .

Mitchell NA, Pepperell E, Ociepka S, Brown JD, Witherington J, Tuladhar B, Sanger GJ, Lee K et al. ( 2009 ) . 5‐hydroxyindalpine, an agonist at the putative 5‐HT1P receptor, has no activity on human recombinant monoamine receptors but accelerates distension‐induced peristalsis in mouse isolated colon . Neurogastroenterology & Motility vol. 21 , ( 7 ) 760 - e48 .

Sung EZ, Jarvie E, James S, Menon VS, Borman RA, Snead D, Sanger GJ, Nwokolo CU ( 2009 ) . W2074 Long-Term Consequences of Neo-Adjuvant Chemotherapy for Oesophago-Gastric Cancer On Gastric Contractility and Innervation . Gastroenterology vol. 136 , ( 5 ) a - 786 .

Wardle KA, Ranson J, Sanger GJ ( 2009 ) . Pharmacological characterization of the vanilloid receptor in the rat dorsal spinal cord . British Journal of Pharmacology vol. 121 , ( 5 ) 1012 - 1016 .

Dass NB, Hill J, Muir A, Testa T, Wise A, Sanger GJ ( 2009 ) . The rabbit motilin receptor: molecular characterisation and pharmacology . British Journal of Pharmacology vol. 140 , ( 5 ) 948 - 954 .

Read KE, Sanger GJ, Ramage AG ( 2009 ) . Evidence for the involvement of central 5‐HT7 receptors in the micturition reflex in anaesthetized female rats . British Journal of Pharmacology vol. 140 , ( 1 ) 53 - 60 .

Sanger GJ ( 2009 ) . Neurokinin NK1 and NK3 receptors as targets for drugs to treat gastrointestinal motility disorders and pain . British Journal of Pharmacology vol. 141 , ( 8 ) 1303 - 1312 .

Jarvie EM, Laidler VJN, Corcoran S, Bassil A, Sanger GJ ( 2009 ) . Differences between the abilities of tegaserod and motilin receptor agonists to stimulate gastric motility in vitro . British Journal of Pharmacology vol. 150 , ( 4 ) 455 - 462 .

Sanger GJ ( 2009 ) . Endocannabinoids and the gastrointestinal tract: what are the key questions? . British Journal of Pharmacology vol. 152 , ( 5 ) 663 - 670 .

Sanger GJ, Yoshida M, Yahyah M, Kitazumi K ( 2009 ) . Increased defecation during stress or after 5‐hydroxytryptophan: selective inhibition by the 5‐HT4 receptor antagonist, SB‐207266 . British Journal of Pharmacology vol. 130 , ( 3 ) 706 - 712 .

Bassil AK, Häglund Y, Brown J, Rudholm T, Hellström PM, Näslund E, Lee K, Sanger GJ ( 2009 ) . Little or no ability of obestatin to interact with ghrelin or modify motility in the rat gastrointestinal tract . British Journal of Pharmacology vol. 150 , ( 1 ) 58 - 64 .

Dass NB, Bassil AK, North‐Laidler VJ, Morrow R, Aziz E, Tuladhar BR, Sanger GJ ( 2009 ) . Neuromedin U can exert colon‐specific, enteric nerve‐mediated prokinetic activity, via a pathway involving NMU1 receptor activation . British Journal of Pharmacology vol. 150 , ( 4 ) 502 - 508 .

Bassil AK, Bourdu S, Townson KA, Wheeldon A, Jarvie EM, Zebda N, Abuin A, Grau E et al. ( 2009 ) . UDP-glucose modulates gastric function through P2Y14 receptor-dependent and -independent mechanisms . AJP Gastrointestinal and Liver Physiology vol. 296 , ( 4 ) g923 - g930 .

Westaway SM, Sanger GJ ( 2009 ) . 2 The Identification of and Rationale for Drugs Which Act at The Motilin Receptor . vol. 48 , Elsevier

Holbrook JD, Gill CH, Zebda N, Spencer JP, Leyland R, Rance KH, Trinh H, Balmer G et al. ( 2009 ) . Characterisation of 5-HT3c, 5-HT3d and 5-HT3e receptor subunits: evolution, distribution and function . J Neurochem vol. 108 , ( 2 ) 384 - 396 .

SANGER GJ, Westaway SM, Brown SL, Fell SCM, Johnson CM, MacPherson DT, Mitchell DJ, Myatt JW et al. ( 2009 ) . Discovery of N-(3-Fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040): The first small molecule motilin receptor agonist clinical candidate . J Med Chem vol. 52 , 1180 - 1189 .

SANGER GJ, Westaway SM, Barnes AA, Macpherson DT, Muir AI, Jarvie EM, Bolton VN, Cellek S et al. ( 2009 ) . GSK962040: a small molecule, selective motilin receptor agonist, effective as a stimulant of human and rabbit gastrointestinal motility . Neurogastroenterology and Motility vol. 21 , 657 - 666 .

Bassil AK, Taylor CM, Bolton VJN, Grey KM, Brown JD, Cutler L, Summerfield SG, Bruton G et al. ( 2009 ) . Inhibition of colonic motility and defecation by RS-127445 suggests an involvement of the 5-HT2B receptor in rodent large bowel physiology . Br J Pharmacol vol. 158 , ( 1 ) 252 - 258 .

Sung EZ, Jarvie E, James S, Menon VS, Borman RA, Snead D, Sanger GJ, Nwokolo CU ( 2009 ) . Long-Term Consequences of Neo-Adjuvant Chemotherapy for Oesophago-Gastric Cancer On Gastric Contractility and Innervation . GASTROENTEROLOGY . vol. 136 , A786 - A786 .

Bailey JM, Scott JS, Basilla JB, Bolton VJ, Boyfield I, Evans DG, Fleury E, Heightman TD et al. ( 2009 ) . The discovery and optimisation of benzazepine sulfonamide and sulfones as potent agonists of the motilin receptor . Bioorg Med Chem Lett vol. 19 , ( 22 ) 6452 - 6458 .

Westaway SM, Sanger GJ ( 2009 ) . The identification and rationale for drugs which act at the motilin receptor . Progress in Medicinal Chemistry vol. 48 , 31 - 80 .

Shafton AD, Sanger GJ, Witherington J, Brown JD, Muir A, Butler S, Abberley L, Shimizu Y et al. ( 2008 ) . Oral administration of a centrally acting ghrelin receptor agonist to conscious rats triggers defecation . Neurogastroenterology & Motility vol. 21 , ( 1 ) 71 - 77 .

Witherington J, Abberley L, Bellenie BR, Boatman R, Collis K, Dean DK, Gaiba A, King NP et al. ( 2008 ) . Aryl sulphonyl amides as potent agonists of the growth hormone secretagogue (ghrelin) receptor . Bioorganic & Medicinal Chemistry Letters vol. 19 , ( 3 ) 684 - 687 .

Heightman TD, Conway E, Corbett DF, Macdonald GJ, Stemp G, Westaway SM, Celestini P, Gagliardi S et al. ( 2008 ) . Identification of small molecule agonists of the motilin receptor . Bioorganic & Medicinal Chemistry Letters vol. 18 , ( 24 ) 6423 - 6428 .

Westaway SM, Brown SL, Conway E, Heightman TD, Johnson CN, Lapsley K, Macdonald GJ, MacPherson DT et al. ( 2008 ) . The discovery of biaryl carboxamides as novel small molecule agonists of the motilin receptor . Bioorganic & Medicinal Chemistry Letters vol. 18 , ( 24 ) 6429 - 6436 .

SUNG EZH, DA SILVA NF, GOODYEAR S, MCTERNAN PG, SANGER GJ, NWOKOLO CU ( 2008 ) . Increased plasma ghrelin following infliximab in Crohn’s disease . Alimentary Pharmacology & Therapeutics vol. 29 , ( 1 ) 83 - 89 .

Jarvie EM, Cellek S, Sanger GJ ( 2008 ) . Potentiation by cholinesterase inhibitors of cholinergic activity in rat isolated stomach and colon . Pharmacological Research vol. 58 , ( 5-6 ) 297 - 301 .

Sanger GJ ( 2008 ) . 5-Hydroxytryptamine and the gastrointestinal tract: where next? . Trends in Pharmacological Sciences vol. 29 , ( 9 ) 465 - 471 .

Bermudez J, Dunbar A, Sanger GJ, Turner DH ( 2008 ) . Stimulation of Canine Gastric Motility by BRL 24924, a New Gastric Prokinetic Agent . Neurogastroenterology & Motility vol. 2 , ( 4 ) 281 - 286 .

Sanger GJ, Bassil AK, Bolton VJ, Taylor CM, Gray K, Winchester WJ, Lee K ( 2008 ) . T1381 Inhibition of Colonic Motility and Defecation By RS-127445 Suggests Involvement of the 5-HT2b Receptor in Large Bowel Physiology . Gastroenterology vol. 134 , ( 4 ) a - 543 .

McRoberts JA, Ennes HS, Ameen VZ, Sanger GJ, Mayer EA ( 2008 ) . W1751 Effects of Alosetron On CGRP Release from Colonic Tissue in Rats . Gastroenterology vol. 134 , ( 4 ) a - 708 .

Malik NM, Moore GBT, Kaur R, Liu Y-L, Wood SL, Morrow RW, Sanger GJ, Andrews PLR ( 2008 ) . Adaptive upregulation of gastric and hypothalamic ghrelin receptors and increased plasma ghrelin in a model of cancer chemotherapy-induced dyspepsia . Peptides vol. 148 , ( 1-3 ) 33 - 38 .

Bolton VN, Bassil AK, Lee K, Sanger GJ ( 2008 ) . Inhibition by tianeptine of neuronally mediated contractions in the rat isolated gastrointestinal tract . Pharmacological Research vol. 57 , ( 5 ) 339 - 343 .

Sanger GJ, Gaster LM ( 2008 ) . Overview Central & Peripheral Nervous System: 5-HT4 receptor antagonists . Expert Opinion on Therapeutic Patents vol. 4 , ( 4 ) 323 - 332 .

Sanger GJ, Lee K ( 2008 ) . Hormones of the gut–brain axis as targets for the treatment of upper gastrointestinal disorders . Nature Reviews Drug Discovery vol. 7 , ( 3 ) 241 - 254 .

Sanger GJ ( 2008 ) . Motilin, ghrelin and related neuropeptides as targets for the treatment of GI diseases . Drug Discovery Today vol. 13 , ( 5-6 ) 234 - 239 .

Bassil AK, Borman RA, Jarvie EM, McArthur-Wilson RJ, Thangiah R, Sung EZ, Lee K, Sanger GJ ( 2008 ) . Activation of prostaglandin EP receptors by lubiprostone in rat and human stomach and colon . Br J Pharmacol vol. 154 , 126 - 135 .

Sanger GJ, Alpers DH ( 2008 ) . Development of drugs for gastrointestinal motor disorders: translating science to clinical need . Neurogastroenterol Motil vol. 20 , 177 - 184 .

McRoberts JA, Ennes HS, Ameen VZ, Sanger GJ, Mayer EA ( 2008 ) . Effects of alosetron on CGRP release from colonic tissue in rats . GASTROENTEROLOGY . vol. 134 , A708 - A708 .

Sanger GJ, Lee K ( 2008 ) . Hormones of the gut-brain axis as targets for the treatment of upper gastrointestinal disorders . NATURE REVIEWS DRUG DISCOVERY vol. 7 , 242 - 254 .

Olsson C, Holbrook JD, Bompadre G, Jönsson E, Hoyle C, Sanger GJ, Holmgren S, Andrews PLR ( 2008 ) . Identification of genes for ghrelin and motilin receptors and a novel related gene in fish, and stimulation of intestinal motility in zebrafish (Danio rerio) by ghrelin and motilin . Gen Comparative Endocrinol vol. 155 , 217 - 226 .

Sanger GJ, Bassil AK, Bolton VJ, Taylor CM, Gray K, Winchester WJ, Lee K ( 2008 ) . Inhibition of colonic motility and defecation by RS-127445 suggests involvement of the 5-HT_2b receptor in large bowel physiology . GASTROENTEROLOGY . vol. 134 , A543 - A543 .

Witherington J, Abberley L, Briggs MA, Collis K, Dean DK, Gaiba A, King PN, Kraus H et al. ( 2008 ) . Potent achiral agonists of the growth hormone secretatgogue (ghrelin) receptor. Part 2 – Lead Optimisation . Bioorg Med Chem Lett vol. 18 , 2203 - 2205 .

Cellek S, Thangiah R, Jarvie EM, Vivekanandan S, Lalude O, Sanger GJ ( 2008 ) . Synergy between 5-HT4 receptor activation and acetylcholinesterase inhibition in human colon and rat forestomach . Neurogastroenterol Motil vol. 20 , 539 - 545 .

Heightman TD, Scott JS, Longley M, Bordas V, Dean DK, Elliott R, Hutley G, Witherington J et al. ( 2007 ) . Potent achiral agonists of the ghrelin (growth hormone secretagogue) receptor. Part I: Lead identification . Bioorganic & Medicinal Chemistry Letters vol. 17 , ( 23 ) 6584 - 6587 .

Sanger GJ ( 2007 ) . Gastrointestinal diseases . Drug Discovery Today Therapeutic Strategies vol. 4 , ( 3 ) 153 - 154 .

Borman RA, Sanger GJ ( 2007 ) . Novel approaches and clinical opportunity for gastrointestinal prokinetic drugs . Drug Discovery Today Therapeutic Strategies vol. 4 , ( 3 ) 165 - 170 .

Shafton AD, Bogeski G, Kitchener PD, Sanger GJ, Furness JB, Shimizu Y ( 2007 ) . Effects of NMDA receptor antagonists on visceromotor reflexes and on intestinal motility, in vivo . Neurogastroenterology & Motility vol. 19 , ( 7 ) 617 - 624 .

Cellek S, Thangiah R, Bassil AK, Campbell CA, Gray KM, Stretton JL, Lalude O, Vivekanandan S et al. ( 2007 ) . Demonstration of Functional Neuronal β3-Adrenoceptors Within the Enteric Nervous System . Gastroenterology vol. 133 , ( 1 ) 175 - 183 .

Cellek S, Thangiah R, Bassil AK, Campbell CA, Gray KM, Stretton JL, Lalude O, Vivekanandan S et al. ( 2007 ) . WITHDRAWN: Demonstration of functional neuronal B3-adrenoceptors within the enteric nervous system . Gastroenterology

Mitchell N, Pepperell EP, Brown JD, Ociepka S, Witherington J, Tuladhar BR, Sanger GJ, Lee K et al. ( 2007 ) . 5-hydroxyindalpine, the putative 5-HT1P receptor agonist, accelerates peristalsis in mouse isolated colon, but has NO effect on the activity of known 5-HT receptors . GASTROENTEROLOGY . vol. 132 , A244 - A244 .

Cellek S, Thangiah R, Bassil AK, Campbell CA, Gray KM, Stretton JL, Lalude O, Vivekanandan S et al. ( 2007 ) . Demonstration of functional neuronal β₃-adrenoceptors within the enteric nervous system (vol 133, pg 175, 2007) . GASTROENTEROLOGY vol. 133 , ( 3 ) 1055 - 1055 .

Bassil AK, Thangiah R, Borman RA, Jarvie EM, Vivekanandan S, Lalude O, Sung EZ, Baragwanath P et al. ( 2007 ) . Effect of lubiprostone on rat and human colon muscle; Possible involvement of prostaglandin Ep receptors . GASTROENTEROLOGY . vol. 132 , A455 - A455 .

Unsworth W, Darton J, Townson KA, Wheeldon A, Winchester WJ, Lee K, Witherington J, Sanger GJ ( 2007 ) . Effects of CP-464709, a small molecule ghrelin receptor agonist, on gastric emptying in the rat . GASTROENTEROLOGY . vol. 132 , A542 - A542 .

Hafsi N, Wollmann J, von weyern CWH, Zeller F, Sanger GJ, Winchester WJ, Lee K, Cellek S et al. ( 2007 ) . Functional and phenotypic characterisation of beta-3 adrenoceptor in human enteric neurons . GASTROENTEROLOGY . vol. 132 , A18 - A18 .

Shimizu Y, Shafton AD, Sanger GJ, Witherington J, Shiina T, Takewaki T, Furness JB ( 2007 ) . Ghrelin receptor agonist enhances colorectal motility and defecation in rats . JOURNAL OF PHARMACOLOGICAL SCIENCES . vol. 103 , 61P - 61P .

Borman RA, Bassil AK, Jarvie EM, Lee K, Sanger GJ ( 2007 ) . Involvement of prostanoids in the ability of lubiprostone to stimulate rat colonic fluid secretion <i>in vitro</i> . GASTROENTEROLOGY . vol. 132 , A455 - A455 .

Dukes GE, Dewit OE, Sanger GJ, Ameen VZ, Northcutt AR, Perschy TL, Schmith GD, Hamedani AG et al. ( 2007 ) . Lack of effect of the NK₃ receptor antagonist, talnerant SB223242 on symptoms of IBS:: Results of 2 randomized, double-blind, placebo-controlled dose ranging trials . GASTROENTEROLOGY . vol. 132 , A60 - A60 .

Sanger GJ, Tuladhar BR, Brown J, Aziz E, Sivakumar D, Furness JB ( 2007 ) . Modulation of peristalsis by NK3 receptor antagonism in guinea-pig isolated ileum is revealed as intraluminal pressure is raised . Autonom Autocoid Pharmacol vol. 27 , 105 - 111 .

Haglund Y, Sanger GJ, Dewit OE, Dukes GE, Hellstrom PM, Naslund E ( 2007 ) . The effect of Ghrelin on gut transit in man . GASTROENTEROLOGY . vol. 132 , A61 - A61 .

Bassil AK, Jarvie EM, Zebda N, Morrison AD, Abuin A, Grau E, Livi GP, Punter L et al. ( 2007 ) . UDP-glucose modulates the contractility of mouse forestomach <i>in vitro</i> via the P2y₁₄ receptor . GASTROENTEROLOGY . vol. 132 , A541 - A541 .

Dass NB, John AK, Bassil AK, Crumbley CW, Shehee WR, Maurio FP, Moore GBT, Taylor CM et al. ( 2006 ) . The relationship between the effects of short‐chain fatty acids on intestinal motility in vitro and GPR43 receptor activation . Neurogastroenterology & Motility vol. 19 , ( 1 ) 66 - 74 .

Malik NM, Liu Y-L, Cole N, Sanger GJ, Andrews PLR ( 2006 ) . Differential effects of dexamethasone, ondansetron and a tachykinin NK1 receptor antagonist (GR205171) on cisplatin-induced changes in behaviour, food intake, pica and gastric function in rats . European Journal of Pharmacology vol. 555 , ( 2-3 ) 164 - 173 .

Shimizu Y, Chang EC, Shafton AD, Ferens DM, Sanger GJ, Witherington J, Furness JB ( 2006 ) . Evidence that stimulation of ghrelin receptors in the spinal cord initiates propulsive activity in the colon of the rat . The Journal of Physiology vol. 576 , ( 1 ) 329 - 338 .

Sanger GJ, Andrews PLR ( 2006 ) . Treatment of nausea and vomiting: Gaps in our knowledge . Autonomic Neuroscience vol. 129 , ( 1-2 ) 3 - 16 .

Bassil AK, Dass NB, Sanger GJ ( 2006 ) . The prokinetic-like activity of ghrelin in rat isolated stomach is mediated via cholinergic and tachykininergic motor neurones . European Journal of Pharmacology vol. 544 , ( 1-3 ) 146 - 152 .

Cellek S, John AK, Thangiah R, Dass NB, Bassil AK, Jarvie EM, Lalude O, Vivekanandan S et al. ( 2006 ) . 5‐HT4 receptor agonists enhance both cholinergic and nitrergic activities in human isolated colon circular muscle . Neurogastroenterology & Motility vol. 18 , ( 9 ) 853 - 861 .

Malik NM, Moore GBT, Smith G, Liu Y-L, Sanger GJ, Andrews PLR ( 2006 ) . Behavioural and hypothalamic molecular effects of the anti-cancer agent cisplatin in the rat: A model of chemotherapy-related malaise? . Pharmacology Biochemistry and Behavior vol. 83 , ( 1 ) 9 - 20 .

Liu Y-L, Malik NM, Sanger GJ, Andrews PLR ( 2006 ) . Ghrelin alleviates cancer chemotherapy-associated dyspepsia in rodents . Cancer Chemotherapy and Pharmacology vol. 58 , ( 3 ) 326 - 333 .

Cellek S, Thangiah R, Bassil AK, Campbell CA, Donaldson KH, Gray KM, O'Shaughnessy CT, Stretton JL et al. ( 2006 ) . Beta-3 adrenoceptor agonism decreases motility and induces anti-hyperalgesia: A novel target for HIS . GASTROENTEROLOGY . vol. 130 , A23 - A23 .

Sanger GJ, Tuladhar BR, Bueno L, Furness JB ( 2006 ) . Defensive and pathological functions of the gastrointestinal NK3 receptor . Vascular Pharmacology vol. 45 , 215 - 220 .

Haglund Y, O'Shaughnessy C, Sanger GJ, Hellstrom PM, Naslund E ( 2006 ) . Fasting small bowel motility reinstated by ghrelin infusion in rats . GASTROENTEROLOGY . vol. 130 , A226 - A226 .

Shimizu Y, Chang EC, Shafton AD, Sanger GJ, Witherington J, Furness JB ( 2006 ) . The effects of a ghrelin receptor agonist on motility reflexes and visceral pain in vivo . GASTROENTEROLOGY . vol. 130 , A226 - A226 .

Sanger GJ, Holzer P ( 2005 ) . Endogenous Opioids and the Gastrointestinal Tract . Seminars in Colon and Rectal Surgery vol. 16 , ( 4 ) 197 - 199 .

Bassil AK, Dass NB, Murray CD, Muir A, Sanger GJ ( 2005 ) . Prokineticin-2, motilin, ghrelin and metoclopramide: Prokinetic utility in mouse stomach and colon . European Journal of Pharmacology vol. 524 , ( 1-3 ) 138 - 144 .

Rudd JA, Ngan MP, Wai MK, King AG, Witherington J, Andrews PLR, Sanger GJ ( 2005 ) . Anti-emetic activity of ghrelin in ferrets exposed to the cytotoxic anti-cancer agent cisplatin . Neuroscience Letters vol. 392 , ( 1-2 ) 79 - 83 .

Liu Y-L, Malik N, Sanger GJ, Friedman MI, Andrews PLR ( 2005 ) . Pica—A model of nausea? Species differences in response to cisplatin . Physiology & Behavior vol. 85 , ( 3 ) 271 - 277 .

Edholm T, Naslund E, Hellstrom PM, Gardner C, Darton J, O'Shaughnesssy C, Witherington J, Sanger GJ ( 2005 ) . Gastro-prokinctic characteristics of ghrelin receptor activation . GASTROENTEROLOGY . vol. 128 , A544 - A545 .

Gale D, Blakemore SJ, Cook T, Kidwai S, Moore I, Moore GB, Moore SE, Sanger GJ et al. ( 2005 ) . Modulation of gene expression in the glandular and non-glandular regions of the rat stomach after treatment with the anti-cancer drug cisplatin . GASTROENTEROLOGY . vol. 128 , A545 - A545 .

King AG, Sanger GJ ( 2004 ) . Effect of a selective and potent central nervous system penetrant, neurokinin-3 receptor antagonist (SB-222200), on cisplatin-induced emesis in the ferret . Neuroscience Letters vol. 376 , ( 1 ) 5 - 8 .

Sanger GJ, Tuladhar BR ( 2004 ) . The role of endogenous opioids in the control of gastrointestinal motility: predictions from in vitro modelling . Neurogastroenterology & Motility vol. 16 , ( s2 ) 38 - 45 .

Shafton AD, Bogeski G, Kitchener PD, Lewis VA, Sanger GJ, Furness JB ( 2004 ) . Effects of the peripherally acting NK3 receptor antagonist, SB‐235375, on intestinal and somatic nociceptive responses and on intestinal motility in anaesthetized rats . Neurogastroenterology & Motility vol. 16 , ( 2 ) 223 - 231 .

O'Connor V, Genin A, Davis S, Karishma KK, Doyère V, De Zeeuw CI, Sanger G, Hunt SP et al. ( 2004 ) . Differential Amplification of Intron-containing Transcripts Reveals Long Term Potentiation-associated Up-regulation of Specific Pde10A Phosphodiesterase Splice Variants* . Journal of Biological Chemistry vol. 279 , ( 16 ) 15841 - 15849 .

Tuladhar BR, Aziz E, Sanger GJ ( 2004 ) . Involvement of endogenous opiates in the inhibitory effect of clonidine on peristalsis in the mouse isolated colon . GASTROENTEROLOGY . vol. 126 , A278 - A278 .

Tuladhar BR, Aziz E, Sanger GJ ( 2004 ) . The NK₃ receptor antagonist talnetant (SB-223412) modulates peristalsis induced by supra-optimal distension pressure in the guinea pig isolated ileum . GASTROENTEROLOGY . vol. 126 , A277 - A277 .

Dass NB, Munonyara M, Bassil AK, Hervieu GJ, Osbourne S, Corcoran S, Morgan M, Sanger GJ ( 2003 ) . Growth hormone secretagogue receptors in rat and human gastrointestinal tract and the effects of ghrelin . Neuroscience vol. 120 , ( 2 ) 443 - 453 .

Bogeski G, Lean NP, Kitchener PD, Timar‐Peregrin A, Sanger GJ, Shafton AD, Furness JB ( 2003 ) . Analysis of factors that determine the compliance of rat jejunum to distension in vivo . Neurogastroenterology & Motility vol. 15 , ( 4 ) 417 - 425 .

Fioramonti J, Gaultier E, Toulouse M, Sanger GJ, Bueno L ( 2003 ) . Intestinal anti‐nociceptive behaviour of NK3 receptor antagonism in conscious rats: evidence to support a peripheral mechanism of action . Neurogastroenterology & Motility vol. 15 , ( 4 ) 363 - 369 .

Hoyle CHV, Hill J, Sanger GJ, Andrews PLR ( 2003 ) . Analysis of pancreatic polypeptide cDNA from the house musk shrew, Suncus murinus, suggests a phylogenetically closer relationship with humans than for other small laboratory animal species . Peptides vol. 114 , ( 2-3 ) 137 - 144 .

Newton RA, Bingham S, Davey P, Medhurst AD, Piercy V, Raval P, Parsons AA, Sanger GJ et al. ( 2003 ) . Molecular Approaches to the Study of Pain . Pain , Taylor & Francis

Dass NB, Bassil AK, Looney NA, Corcoran SL, Hervieu G, Sanger GJ ( 2003 ) . Neuromedin U-R2 localisation in the mouse gastrointestinal tract and the effects of rat NmU-23 . Gastroenterology . vol. 124 , a139 - a140 .

Génin A, French P, Doyère V, Davis S, Errington ML, Maroun M, Stean T, Truchet B et al. ( 2003 ) . LTP but not seizure is associated with up‐regulation of AKAP‐150 . European Journal of Neuroscience vol. 17 , ( 2 ) 331 - 340 .

Read KE, Sanger GJ, Ramage AG ( 2003 ) . Evidence that central 5-HT₇ receptors are involved in the control of micturition in urethane anaesthetized rats . BRITISH JOURNAL OF PHARMACOLOGY . vol. 138 , U2 - U2 .

Andrews PLR, Sanger GJ ( 2002 ) . Abdominal vagal afferent neurones: an important target for the treatment of gastrointestinal dysfunction . Current Opinion in Pharmacology vol. 2 , ( 6 ) 650 - 656 .

Sanger GJ, Hicks GA ( 2002 ) . Drugs targeting functional bowel disorders: insights from animal studies . Current Opinion in Pharmacology vol. 2 , ( 6 ) 678 - 683 .

Furness JB, Sanger GJ ( 2002 ) . Gastrointestinal neuropharmacology: identification of therapeutic targets . Current Opinion in Pharmacology vol. 2 , ( 6 ) 609 - 611 .

Furness JB, Sanger GJ ( 2002 ) . Intrinsic nerve circuits of the gastrointestinal tract: identification of drug targets . Current Opinion in Pharmacology vol. 2 , ( 6 ) 612 - 622 .

Sanger GJ, Munonyara ML, Dass N, Prosser H, Pangalos MN, Parsons ME ( 2002 ) . GABAB receptor function in the ileum and urinary bladder of wildtype and GABAB1 subunit null mice . Autonomic and Autacoid Pharmacology vol. 22 , ( 3 ) 147 - 154 .

Gaster LM, Jennings AJ, Joiner GF, King FD, Mulholland KR, Rahman SK, Starr S, Wyman PA et al. ( 2002 ) . (1-Butyl-4-piperidinyl)methyl 8-amino-7-chloro-1,4-benzodioxane-5-carboxylate hydrochloride: a highly potent and selective 5-HT4 receptor antagonist derived from metoclopramide . Journal of Medicinal Chemistry vol. 36 , ( 25 ) 4121 - 4123 .

Bermudez J, Fake CS, Joiner GF, Joiner KA, King FD, Miner WD, Sanger GJ ( 2002 ) . 5-Hydroxytryptamine (5-HT3) receptor antagonists. 1. Indazole and indolizine-3-carboxylic acid derivatives . Journal of Medicinal Chemistry vol. 33 , ( 7 ) 1924 - 1929 .

King FD, Dabbs S, Bermudez J, Sanger GJ ( 2002 ) . Benzotriazinones as "virtual ring" mimics of o-methoxybenzamides: novel and potent 5-HT3 receptor antagonists . Journal of Medicinal Chemistry vol. 33 , ( 11 ) 2942 - 2944 .

Gaster LM, Joiner GF, King FD, Wyman PA, Sutton JM, Bingham S, Ellis ES, Sanger GJ et al. ( 2002 ) . N-[(1-butyl-4-piperidinyl)methyl]-3,4dihydro-2H-[1,3]oxazino[3,2- a]indole10-carboxamide hydrochloride: the first potent and selective 5-HT4 receptor antagonist amide with oral activity . Journal of Medicinal Chemistry vol. 38 , ( 24 ) 4760 - 4763 .

King FD, Hadley MS, Joiner KT, Martin RT, Sanger GJ, Smith DM, Smith GE, Smith P et al. ( 2002 ) . Substituted benzamides with conformationally restricted side chains. 5. Azabicyclo[x.y.z] derivatives as 5-HT4 receptor agonists and gastric motility stimulants . Journal of Medicinal Chemistry vol. 36 , ( 6 ) 683 - 689 .

Timar‐Peregrin A, Kumano K, Khalil Z, Sanger GJ, Furness JB ( 2002 ) . The relationship between propagated contractions and pseudoaffective changes in blood pressure in response to intestinal distension . Neurogastroenterology & Motility vol. 13 , ( 6 ) 575 - 584 .

SANGER, SMITH, WARDLE ( 2002 ) . SB‐207266: 5‐HT4 receptor antagonism in human isolated gut and prevention of 5‐HT‐evoked sensitization of peristalsis and increased defaecation in animal models . Neurogastroenterology & Motility vol. 10 , ( 4 ) 271 - 279 .

Murray C, Emmanuel NDA, Sanger GJ ( 2002 ) . Facilitation by ghrelin and metoclopramide of nerve-mediated excitatory responses in mouse gastric fundus circular muscle . BRITISH JOURNAL OF PHARMACOLOGY . vol. 136 ,

Dass N, Bassil AK, Morgan M, Sanger GJ ( 2002 ) . Localisation and distribution of functional neurokinin-3 (NK3) receptors in the human gastrointestinal tract . GASTROENTEROLOGY . vol. 122 , A257 - A257 .

Hill J, Szekeres P, Muir A, Sanger GJ ( 2002 ) . Molecular, functional and cross-species comparisons between the receptors for the prokinetic neuropeptides, motilin and ghrelin . GASTROENTEROLOGY . vol. 122 , A54 - A54 .

Sanger GJ, Alex G, Shafton AD, Furness JB ( 2002 ) . NK3 receptor antagonism by talnetant (SB-223412) suggests a role for NK3 receptors in enteric reflexes evoked by relatively intense stimuli . GASTROENTEROLOGY . vol. 122 , A256 - A256 .

Newton RA, Bingham S, Case PC, Sanger GJ, Lawson SN ( 2001 ) . Dorsal root ganglion neurons show increased expression of the calcium channel α2δ-1 subunit following partial sciatic nerve injury . Brain Research vol. 95 , ( 1-2 ) 1 - 8 .

Fedouloff M, Hossner F, Voyle M, Ranson J, Powles J, Riley G, Sanger G ( 2001 ) . Synthesis and pharmacological activity of metabolites of the 5-HT4 receptor antagonist SB-207266 . Bioorganic & Medicinal Chemistry vol. 9 , ( 8 ) 2119 - 2128 .

Medhurst AD, Lezoualc’h F, Fischmeister R, Middlemiss DN, Sanger GJ ( 2001 ) . Quantitative mRNA analysis of five C-terminal splice variants of the human 5-HT4 receptor in the central nervous system by TaqMan real time RT-PCR . Brain Research vol. 90 , ( 2 ) 125 - 134 .

SANGER G, BEECHAM S, KUCHAI R, MORGAN M ( 2001 ) . Excitatory and inhibitory neuroanally-mediated actiens of orexin-A and melaniaconcentrating hormone (MCH) in human isolated colon . Gastroenterology . vol. 120 , a172 - a172 .

SANGER G, MUNONYARA M, PROSSER H, PANGALOS M, HUNTER A, PARSONS M ( 2001 ) . GABAb receptor-mediated inhibition of cholinergic function in mouse ileum requires the GABAb1 subunit . Gastroenterology . vol. 120 , a198 - a198 .

TIMARPEREGRIN A, KUMANO K, KHALIL Z, SANGER G, BEECHAM S, FURNESS J ( 2001 ) . Simultaneous recording of pseudoaffective reflexes and motor activity in the jejunum of the anesthetized rat . Gastroenterology . vol. 120 , a717 - a717 .

Dass N, Davis JB, Sanger GJ ( 2001 ) . Responses to <i>E</i>-capsaicin in detrusor tissue from both wildtype and vanilloid receptor-1 null mice . BRITISH JOURNAL OF PHARMACOLOGY . vol. 133 , U10 - U10 .

Hayes P, Meadows HJ, Gunthorpe MJ, Harries MH, Duckworth DM, Cairns W, Harrison DC, Clarke CE et al. ( 2000 ) . Cloning and functional expression of a human orthologue of rat vanilloid receptor-1 . Pain vol. 88 , ( 2 ) 205 - 215 .

Rausch O, Newton RA, Bingham S, Macdonald R, Case CP, Sanger GJ, Lawson SN, Reith AD ( 2000 ) . Nerve injury-associated kinase: a sterile 20-like protein kinase up-regulated in dorsal root ganglia in a rat model of neuropathic pain . Neuroscience vol. 101 , ( 3 ) 767 - 777 .

French PJ, O'Connor V, Wills T, Bliss TVP, Davis S, Doyere V, Laroche S, Hunt SP et al. ( 2000 ) . Identification of novel genes associated with the induction of LTP <i>in vivo</i> . EUROPEAN JOURNAL OF NEUROSCIENCE . vol. 12 , 346 - 346 .

Genin A, Mallet J, French PJ, O'Connor V, Bliss TVP, Davis S, Doyere V, Laroche S et al. ( 2000 ) . Modulation of the mRNA encoding the A-kinase anchoring protein AKAP150 following the induction of LTP in the dentate gyrus <i>in vivo</i> . EUROPEAN JOURNAL OF NEUROSCIENCE . vol. 12 , 389 - 389 .

Rausch O, Newton R, Bingham S, MacDonald R, Case P, Lawson S, Sanger G, Reith AD ( 2000 ) . NAK; A ste20-like kinase induced in dorsal root ganglia in an animal model of neuropathic pain . EUROPEAN JOURNAL OF NEUROSCIENCE . vol. 12 , 230 - 230 .

Sanger GJ, Ellis ES, Harries MH, Tilford NS, Wardle KA, Benham CD ( 2000 ) . Rank-order inhibition by ω-conotoxins in human and animal autonomic nerve preparations . European Journal of Pharmacology vol. 388 , ( 1 ) 89 - 95 .

Newton RA, Bingham S, Davey PD, Medhurst AD, Piercy V, Raval P, Parsons AA, Sanger GJ et al. ( 1999 ) . Identification of differentially expressed genes in dorsal root ganglia following partial sciatic nerve injury . Neuroscience vol. 95 , ( 4 ) 1111 - 1120 .

Wood MD, Murkitt KL, Gager T, Ranson J, Sanger GJ ( 1999 ) . Pharmacological characterisation of the human P2X<inf>4</inf> receptor using the FLIPR . Pharmacology Reviews and Communications vol. 10 , ( 4 ) 341 - 347 .

Carpenter D, Meadows HJ, Brough S, Chapman G, Clarke C, Coldwell M, Davis R, Harrison D et al. ( 1999 ) . Site-specific splice variation of the human P2X4 receptor . Neuroscience Letters vol. 273 , ( 3 ) 183 - 186 .

Sanger GJ ( 1999 ) . Hypersensitivity and Hyperreactivity in the Irritable Bowel Syndrome: An Opportunity for Drug Discovery . Digestive Diseases vol. 17 , ( 2 ) 90 - 99 .

Smith MI, Banner SE, Sanger GJ ( 1999 ) . 5-HT4 receptor antagonism potentiates inhibition of intestinal allodynia by 5-HT3 receptor antagonism in conscious rats . Neuroscience Letters vol. 271 , ( 1 ) 61 - 64 .

Piercy V, Banner SE, Bhattacharyya A, Parsons AA, Sanger GJ, Smith SA, Bingham S ( 1999 ) . Thermal, But Not Mechanical, Nociceptive Behavior is Altered in the Zucker Diabetic Fatty Rat and Is Independent of Glycemic Status . Journal of Diabetes and its Complications vol. 13 , ( 3 ) 163 - 169 .

Reavill C, Hatcher JP, Lewis VA, Sanger GJ, Hagan J ( 1998 ) . 5-HT4 receptor antagonism does not affect motor and reward mechanisms in the rat . European Journal of Pharmacology vol. 357 , ( 2-3 ) 115 - 120 .

Clarke CE, Meadows HJ, Tomlinson WJ, Carpenter D, Sanger GJ, Benham CD ( 1998 ) . Extracellular acidification inhibits current flow through human P2X₄ receptors expressed in <i>Xenopus</i> oocytes . JOURNAL OF PHYSIOLOGY-LONDON . vol. 506P , 44P - 45P .

King FD, Gaster LM, Sanger GJ, Wardle KA ( 1998 ) . Modulators of 5-HT functions in the treatment of Gastrointestinal Disorders . Trends in Drug Research II, Proceedings of the 11th Noordwijkerhout-Camerino Symposium , vol. 29 , Elsevier

Sanger GJ ( 1998 ) . Therapeutic Applications of 5-HT4 Receptor Agonists and Antagonists . 5-HT4 Receptors in the Brain and Periphery , Springer Nature

Kennett GA, Bright F, Trail B, Blackburn TP, Sanger GJ ( 1997 ) . Anxiolytic-like Actions of the Selective 5-HT4 Receptor Antagonists SB 204070A and SB 207266A in Rats . Neuropharmacology vol. 36 , ( 4-5 ) 707 - 712 .

Kennett GA, Bright F, Trail B, Blackburn TP, Sanger GJ ( 1997 ) . Effects of SB 204070A and SB 207266A, selective 5-HT4 receptor antagonists, in three rat models of anxiety . BRITISH JOURNAL OF PHARMACOLOGY . vol. 120 , P138 - P138 .

Wardle KA, Ranson J, Sanger GJ ( 1997 ) . Pharmacological characterisation of the vanilloid receptor in the rat dorsal spinal cord . BRITISH JOURNAL OF PHARMACOLOGY . vol. 120 , P228 - P228 .

Wardle KA, Sanger GJ ( 1997 ) . SB 207266 is a potent 5-HT4 receptor antagonist in human isolated gastrointestinal tissue . BRITISH JOURNAL OF PHARMACOLOGY . vol. 120 , P192 - P192 .

Banner SE, Smith MI, Bywater D, Gaster LM, Sanger GJ ( 1996 ) . Increased defaecation caused by 5-HT4 receptor activation in the mouse . European Journal of Pharmacology vol. 308 , ( 2 ) 181 - 186 .

Wardle KA, Furey G, Sanger GJ ( 1996 ) . Pharmacological Characterization of the Vanilloid Receptor in the Rat Isolated Vas Deferens . Journal of Pharmacy and Pharmacology vol. 48 , ( 3 ) 285 - 291 .

Reavill C, Hatcher JP, Zetterstrom TSC, Lewis AV, Sanger GJ, Hagan JJ, McKay S ( 1996 ) . 5-HT4 receptor antagonism does not affect dopamine-mediated behavioural effects in the rat . BRITISH JOURNAL OF PHARMACOLOGY . vol. 118 , P71 - P71 .

Ellis ES, Tilford NS, Baxter GS, Sanger GJ ( 1996 ) . A comparison of N-type calcium channels in human and rat isolated vas deferens by rank order of omega-conotoxin activity . BRITISH JOURNAL OF PHARMACOLOGY . vol. 117 , P204 - P204 .

Wardle KA, Bingham S, Ellis ES, Gaster LM, Rushant B, Smith MI, Brown AM, Young TJ et al. ( 1996 ) . SB 207266: The first potent and selective 5-HT4 receptor antagonist amide with oral activity . BRITISH JOURNAL OF PHARMACOLOGY . vol. 117 , P126 - P126 .

Banner SE, Carter M, Sanger GJ ( 1995 ) . 5-Hydroxytryptamine3 receptor antagonism modulates a noxious visceral pseudoaffective reflex . Neuropharmacology vol. 34 , ( 3 ) 263 - 267 .

Bingham S, King BF, Rushant B, Smith MI, Gaster L, Sanger GJ ( 1995 ) . Antagonism by SB 204070 of 5-HT-evoked Contractions in the Dog Stomach: an In-vivo Model of 5-HT4 Receptor Function . Journal of Pharmacy and Pharmacology vol. 47 , ( 3 ) 219 - 222 .

Franks CM, Hardcastle J, Hardcastle PT, Sanger GJ ( 1995 ) . Do 5-HT4 Receptors Mediate the Intestinal Secretory Response to 5-HT in Rat In-vivo? . Journal of Pharmacy and Pharmacology vol. 47 , ( 3 ) 213 - 218 .

WARDLE KA, FUREY G, SANGER GJ ( 1995 ) . FURTHER CHARACTERIZATION OF THE VANILLOID RECEPTOR IN THE RAT ISOLATED VAS-DEFERENS . BRITISH JOURNAL OF PHARMACOLOGY . vol. 115 , P144 - P144 .

DAVEY PT, BANNER SE, HAMILTON TC, SANGER GJ ( 1995 ) . INHIBITION BY CAPSAZEPINE AND RUTHENIUM RED OF THE PRONOCICEPTIVE AND ANTINOCICEPTIVE EFFECTS OF OLVANIL . BRITISH JOURNAL OF PHARMACOLOGY . vol. 115 , P100 - P100 .

Sanger GJ, Wardle KA ( 1994 ) . Constipation Evoked by 5-HT3-Receptor Antagonism: Evidence for Heterogeneous Efficacy among Different Antagonists in Guinea-pigs . Journal of Pharmacy and Pharmacology vol. 46 , ( 8 ) 666 - 670 .

Bermudez J, Sanger GJ ( 1994 ) . Prolonged anti-emetic activity and 5-HT3-receptor antagonism by BRL 46470 in conscious ferrets . Journal of Pharmacy and Pharmacology vol. 46 , ( 6 ) 520 - 521 .

ELLIS ES, WARDLE KA, BAXTER GS, SANGER GJ ( 1994 ) . 5-HT4, RECEPTOR-MEDIATED CONTRACTIONS IN GUINEA-PIG DISTAL COLON CIRCULAR MUSCLE . BRITISH JOURNAL OF PHARMACOLOGY . vol. 112 , U54 - U54 .

Sanger GJ, Gaster LM ( 1994 ) . 5-HT<inf>4</inf> receptor antagonists . Expert Opinion on Therapeutic Patents vol. 4 , ( 4 ) 323 - 334 .

DAVEY PT, HAMILTON TC, SANGER GJ ( 1994 ) . DIVERGENT EFFECTS OF OLVANIL IN 2 ACUTE MODELS OF NOCICEPTION IN THE MOUSE . BRITISH JOURNAL OF PHARMACOLOGY . vol. 112 , U91 - U91 .

Bingham S, Blower PR, Davey PT, King PD, Sanger GJ, Wardle KA, Nishioka Y ( 1994 ) . Differences between the anti-emetic efficacies of the 5-HT<inf>3</inf> receptor antagonists granisetron and azasetron in the conscious ferret . Pharmacometrics vol. 47 , ( 1 ) 21 - 28 .

Gaster LM, Sanger GJ ( 1994 ) . SB-204070: 5-HT4 receptor antagonists and their potential therapeutic utility . Drugs of the Future vol. 19 , ( 12 )

BAXTER GS, SANGER GJ, GASTER LM, WARDLE KA ( 1994 ) . TISSUE AND AGONIST-DEPENDENT NON-SURMOUNTABLE ANTAGONISM BY THE SELECTIVE 5-HT4 RECEPTOR ANTAGONIST SB-204070 . BRITISH JOURNAL OF PHARMACOLOGY . vol. 112 , U55 - U55 .

Blackburn TP, Baxter GS, Kennett GA, King FD, Piper DC, Sanger GJ, Thomas DR, Upton N et al. ( 1993 ) . BRL 46470A: a highly potent, selective and long acting 5-HT3 receptor antagonist with anxiolytic-like properties . Psychopharmacology vol. 110 , ( 3 ) 257 - 264 .

BANNER SE, SMITH MI, SANGER GJ ( 1993 ) . 5-HT RECEPTORS AND 5-HYDROXYTRYPTOPHAN-EVOKED DEFECATION IN MICE . BRITISH JOURNAL OF PHARMACOLOGY . vol. 110 , P135 - P135 .

BANNER SE, SMITH MI, BYWATER D, SANGER GJ ( 1993 ) . 5-HT4 RECEPTOR ANTAGONISM BY SB-204070 INHIBITS 5-HYDROXYTRYPTOPHAN-EVOKED DEFECATION IN MICE . BRITISH JOURNAL OF PHARMACOLOGY . vol. 110 , P17 - P17 .

WARDLE KA, ELLIS ES, GASTER LM, KING FD, SANGER GJ ( 1993 ) . SB-204070 - A HIGHLY POTENT AND SELECTIVE 5-HT4 RECEPTOR ANTAGONIST . BRITISH JOURNAL OF PHARMACOLOGY . vol. 110 , P15 - P15 .

BINGHAM S, KING BF, RUSHANT B, SMITH MI, SANGER GJ ( 1993 ) . THE 5-HT4 RECEPTOR ANTAGONIST SB-204070 INHIBITS THE CONTRACTILE RESPONSE TO 5-HT IN THE DOG HEIDENHAIN POUCH . BRITISH JOURNAL OF PHARMACOLOGY . vol. 110 , P16 - P16 .

Bermudez J, King FD, Sanger GJ ( 1992 ) . Indazole and indoline as aromatic bioisosteres in the imidazole class of serotonin 5-HT3 receptor antagonists . Bioorganic & Medicinal Chemistry Letters vol. 2 , ( 12 ) 1509 - 1512 .

Bennett A, Stamford IF, Sanger GJ, Bloom SR ( 1992 ) . The Effects of Various Peptides on Human Isolated Gut Muscle . Journal of Pharmacy and Pharmacology vol. 44 , ( 12 ) 960 - 967 .

BAXTER GS, BLACKBURN TP, SANGER GJ, WARDLE KA ( 1992 ) . ACTIONS OF DAU 6285 AT PUTATIVE 5-HT4 RECEPTORS IN GUINEA-PIG COLON AND RAT ESOPHAGUS . BRITISH JOURNAL OF PHARMACOLOGY . vol. 106 , P99 - P99 .

KING BF, SANGER GJ ( 1992 ) . FACILITATION OF NONCHOLINERGIC NEUROTRANSMISSION BY RENZAPRIDE (BRL-24924) IN CIRCULAR MUSCLE OF GUINEA-PIG ILEUM . BRITISH JOURNAL OF PHARMACOLOGY . vol. 107 , P313 - P313 .

Sanger GJ, Wardle KA, Shapcott S, Yee KF ( 1991 ) . Constipation Evoked by 5-HT3 Receptor Antagonists . 381 - 388 .

Sanger GJ ( 1990 ) . New antiemetic drugs . Canadian Journal of Physiology and Pharmacology . vol. 68 , 314 - 324 .

Sanger GJ, Wardle KA ( 1990 ) . 5-Hydroxytryptamine and Cholinergic Function in the Gastrointestinal Tract . 251 - 255 .

Bermudez J, Dunbar A, Sanger GJ, Turner DH ( 1990 ) . Stimulation of canine gastric motility by BRL 24924, a new gastric prokinetic agent . Journal of Gastrointestinal Motility vol. 2 , ( 4 ) 281 - 286 .

SANGER GJ ( 1990 ) . THE DEVELOPMENT OF SELECTIVE 5-HT3 RECEPTOR ANTAGONISTS AS ANTIEMETIC AGENTS . BRITISH JOURNAL OF CANCER . vol. 62 , 479 - 479 .

Wardle KA, Sanger GJ ( 1989 ) . Atypical 5-HT receptors in guinea-pig isolated ileum . British Journal of Pharmacology vol. 98 Suppl ,

King FD, Sanger GJ ( 1989 ) . 5-HT3 RECEPTOR ANTAGONISTS . Drugs of the Future vol. 14 , ( 9 )

Sanger GJ, Nelson DR ( 1989 ) . Selective and functional 5-hydroxytryptamine3 receptor antagonism by BRL 43694 (granisetron) . European Journal of Pharmacology vol. 159 , ( 2 ) 113 - 124 .

Sanger GJ, King FD ( 1988 ) . From metoclopramide to selective gut motility stimulants and 5-HT3 receptor antagonists . Drug Design and Discovery vol. 3 , ( 4 ) 273 - 295 .

Bermudez J, Boyle E, Miner W, Sanger G ( 1988 ) . The anti-emetic potential of the 5-hydroxytryptamine3 receptor antagonist BRL 43694 . British Journal of Cancer vol. 58 , ( 5 ) 644 - 650 .

Andrews PLR, Rapeport WG, Sanger GJ ( 1988 ) . Neuropharmacology of emesis induced by anti-cancer therapy . Trends in Pharmacological Sciences vol. 9 , ( 9 ) 334 - 341 .

King FD, Sanger GJ ( 1988 ) . Chapter 21. Gastrointestinal Motility Enhancing Agents . Annual Reports in Medicinal Chemistry vol. 23 , 201 - 210 .

Sanger GJ ( 1987 ) . Activation of a myenteric 5-hydroxytryptamine-like receptor by metoclopramide . Journal of Pharmacy and Pharmacology vol. 39 , ( 6 ) 449 - 453 .

BOYLE EA, MINER WD, SANGER GJ ( 1987 ) . ANTIEMETIC ACTIVITY OF BRL43694, A NOVEL 5HT3-RECEPTOR ANTAGONIST . BRITISH JOURNAL OF CANCER . vol. 56 , 227 - 227 .

SANGER GJ ( 1987 ) . Evidence that 5-hydroxytryptamine3 receptors mediate cytotoxic drug and radiation-evoked emesis . British Journal of Cancer vol. 56 , 159 - 162 .

ANDREWS PLR, HAWTHORN J, SANGER GJ ( 1987 ) . THE EFFECT OF ABDOMINAL VISCERAL NERVE LESIONS AND A NOVEL 5HT-M RECEPTOR ANTAGONIST ON CYTOTOXIC AND RADIATION-INDUCED EMESIS IN THE FERRET . JOURNAL OF PHYSIOLOGY-LONDON . vol. 382 , P47 - P47 .

Sanger GJ, McClelland CM ( 1986 ) . Increased gastric cholinergic activity evoked by 5-hydroxy-L-tryptophan in the rat . European Journal of Pharmacology vol. 127 , ( 3 ) 179 - 185 .

SANGER GJ, Miner WD ( 1986 ) . Inhibition of cisplatin-induced vomiting by selective 5-hydroxytryptamine M-receptor antagonism . British Journal of Pharmacology vol. 88 , 497 - 499 .

Sanger GJ ( 1985 ) . Effects of metoclopramide and domperidone on cholinergically mediated contractions of human isolated stomach muscle . Journal of Pharmacy and Pharmacology vol. 37 , ( 9 ) 661 - 664 .

Sanger GJ ( 1985 ) . The effects of various pharmacological agents on the metoclopramide-induced increase in cholinergic-mediated contractions of rat isolated forestomach . European Journal of Pharmacology vol. 114 , ( 2 ) 139 - 145 .

Sanger GJ ( 1985 ) . Three different ways in which 5-hydroxytryptamine can affect cholinergic activity in guinea-pig isolated ileum . Journal of Pharmacy and Pharmacology vol. 37 , ( 8 ) 584 - 586 .

McRitchie B, McClelland CM, Cooper SM, Turner DH, Sanger GJ ( 1984 ) . Dopamine Antagonists as Anti-Emetics and as Stimulants of Gastric Motility . Mechanisms of Gastrointestinal Motility and Secretion , Springer Nature

MCCLELLAND CM, SANGER GJ ( 1984 ) . METOCLOPRAMIDE (MCP) IS A POTENT STIMULANT OF CHOLINERGIC ACTIVITY IN RAT AND HUMAN ISOLATED STOMACH . GUT . vol. 25 , 1315 - 1315 .

Sanger GJ ( 1984 ) . Mechanisms by which Metoclopramide can Increase Gastrointestinal Motility . Mechanisms of Gastrointestinal Motility and Secretion , Springer Nature

Bennett A, Sanger GJ ( 1984 ) . Relationships of Prostaglandins to Gastrointestinal Motility and Secretion . Mechanisms of Gastrointestinal Motility and Secretion , Springer Nature

Sanger GJ, Bennett A ( 1984 ) . Techniques for Studying Gastrointestinal Motility in Vitro . Mechanisms of Gastrointestinal Motility and Secretion , Springer Nature

Bennett A, Sanger GJ, Stamford IF, Hensby CN ( 1983 ) . Prostanoids formed by human gastrointestinal tissues and their effects on muscle activity . Advances in Prostaglandin, Thromboxane, and Leukotriene Research vol. 12 , 379 - 381 .

Sanger GJ, Jackson A, Bennett A ( 1982 ) . A prostaglandin analogue which potently relaxes human uterus but not gut muscle . European Journal of Pharmacology vol. 81 , ( 1 ) 141 - 143 .

Sanger GJ, Hensby CN, Stamford IF, Bennett A ( 1981 ) . Identification of arachidonic acid metabolites extracted from human uterus, and their effects on the isolated myometrium . Journal of Pharmacy and Pharmacology vol. 33 , ( 1 ) 607 - 610 .

SANGER GJ, BENNETT A ( 1981 ) . Secoverine hydrochloride is a muscarinic antagonist in human isolated gastrointestinal muscle and myometrium . Journal of Pharmacy and Pharmacology vol. 33 , ( 1 ) 711 - 714 .

Bennet A, Hensby CN, Sanger GJ, Stamford IF ( 1981 ) . Identification and Distribution of Arachidonic Acid Metabolites in the Human Gastrointestinal Tract, and the Ways in Which Some of these Affect the Longitudinal Muscle . The Prostaglandin System , Springer Nature

Sanger GJ, Bennett A ( 1981 ) . Prostanoid Agonists and Antagonists: Differentiation of Prostanoid Receptors in the Gut . The Prostaglandin System , Springer Nature

Sanger GJ, Bennett A ( 1980 ) . Regional differences in the responses to prostanoids of circular muscle from guinea-pig isolated intestine . Journal of Pharmacy and Pharmacology vol. 32 , ( 1 ) 705 - 708 .

Sanger GJ, Watt AJ ( 1980 ) . Some mechanisms which may modulate noradrenaline release in guinea-pig isolated ileum . Journal of Pharmacy and Pharmacology vol. 32 , ( 1 ) 188 - 191 .

Lacey SM, Sanger GJ ( 1980 ) . Antagonism of prostanoid-induced contractions of rat stomach muscle by trimethoquinol or isoxsuprine . British Journal of Pharmacology vol. 70 , ( 1 )

Sanger GJ, Bennett A ( 1980 ) . PGI2 or PGE2 selectively antagonize responses to excitatory PGs in human isolated myometrium . Advances in Prostaglandin, Thromboxane, and Leukotriene Research vol. 6 , 399 - 400 .

Bennett A, Sanger GJ ( 1980 ) . Prostacyclin relaxes the longitudinal muscle of human isolated stomach and antagonizes contractions to some prostanoids [proceedings] . The Journal of Physiology vol. 298 , 45p - 46p .

Sanger GJ, Bennett A ( 1980 ) . Trimethoquinol selectively antagonizes contractions of rat gastric fundus to TXB2 and epoxymethano analogs of PGH2 . Advances in Prostaglandin, Thromboxane, and Leukotriene Research vol. 8 , 1559 - 1560 .

Bennett A, Sanger GJ ( 1979 ) . Prostacyclin and prostaglandin E2 selectively antagonize responses of human isolated myometrium to excitatory prostaglandins [proceedings] . The Journal of Physiology vol. 292 , 36p - 37p .

Bennett A, Carroll MA, Sanger GJ ( 1979 ) . Sodium flufenamate antagonises the potentiation by prostaglandins of noradrenaline-induced vasoconstriction in rat mesentery [proceedings] . British Journal of Pharmacology vol. 66 , ( 3 )

Bennett A, Sanger GJ ( 1979 ) . Trimethoquinol selectively antagonises longitudinal muscle contractions of rat isolated gastric fundus to thromboxane B2 and epoxymethano analogues of PGH2 [proceedings] . British Journal of Pharmacology vol. 66 , ( 3 )

Sanger GJ, Watt AJ ( 1978 ) . The effect of PGE1 on peristalsis and on perivascular nerve inhibition of peristaltic activity in guinea-pig isolated ileum . Journal of Pharmacy and Pharmacology vol. 30 , ( 1 ) 762 - 765 .

Bennett A, Sanger GJ ( 1978 ) . The effects of prostaglandin D2 on the circular muscle of guinea-pig isolated ileum and colon [proceedings] . British Journal of Pharmacology vol. 63 , ( 2 ) 357p - 358p .

Sanger GJ, Watt AJ ( 1976 ) . A postsynaptic action of prostaglandin E1 on sympathetic responses in guinea-pig ileum [proceedings] . British Journal of Pharmacology vol. 58 , ( 2 ) 290p - 291p .

Blair EL, Grund ER, Reed JD, Sanders DJ, Sanger G, Shaw B ( 1975 ) . The effect of sympathetic nerve stimulation on serum gastrin, gastric acid secretion and mucosal blood flow responses to meat extract stimulation in anaesthetized cats . The Journal of Physiology vol. 253 , ( 2 ) 493 - 504 .