Publications:  Mr George Elia

Baker A-M, Cereser B, Melton S, Fletcher AG, Rodriguez-Justo M, Tadrous PJ, Humphries A, Elia G et al.(2019). Quantification of Crypt and Stem Cell Evolution in the Normal and Neoplastic Human Colon. Cell Rep vol. 27, (8) 2524-2524.

Cereser B, Jansen M, Austin E, Elia G, McFarlane T, van Deurzen CH, Sieuwerts AM, Daidone MG et al.(2018). Analysis of clonal expansions through the normal and premalignant human breast epithelium reveals the presence of luminal stem cells. J Pathol vol. 244, (1) 61-70.

Thorat MA, Jones LJ, Levey PM, Elia G, Evagora CA, Bundred NJ, Fentiman IS, Forbes JF et al. (2016). Prognostic role and impact of multi -clonal ER and PgR expression in ductal carcinoma in situ: Results from the UK/ANZ DCIS trial. CANCER RESEARCH. vol. 76,

Thorat MA, Jones LJ, Levey PM, Elia G, Evagora CA, Bundred NJ, Fentiman IS, Forbes JF et al. (2016). Prognostic role and impact of multi-clonal ER and PgR expression in ductal carcinoma in situ: Results from the UK/ANZ DCIS trial. CANCER RESEARCH. vol. 76,

Baker A-M, Graham TA, Elia G, Wright NA, Rodriguez-Justo M(2015). Characterization of LGR5 stem cells in colorectal adenomas and carcinomas. Sci Rep vol. 5,

Wong P-P, Demircioglu F, Ghazaly E, Alrawashdeh W, Stratford MRL, Scudamore CL, Cereser B, Crnogorac-Jurcevic T et al.(2015). Dual-action combination therapy enhances angiogenesis while reducing tumor growth and spread. Cancer Cell vol. 27, (1) 123-137.

Wong P-P, Demircioglu F, Ghazaly E, Alrawashdeh W, Stratford M, Scudamore C, Cereser B, Crnogorac-Jurcevic T et al. (2015). NOVEL DUAL-ACTION COMBINATION THERAPY ENHANCES ANGIOGENESIS WHILST REDUCING TUMOR GROWTH AND SPREAD. JOURNAL OF VASCULAR RESEARCH. vol. 52, 6-6.

Tavora B, Reynolds LE, Batista S, Demircioglu F, Fernandez I, Lechertier T, Lees DM, Wong P-P et al.(2014). Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy. Nature vol. 514, (7520) 112-116.

Batista S, Maniati E, Reynolds LE, Tavora B, Lees DM, Fernandez I, Elia G, Casanovas O et al.(2014). Haematopoietic focal adhesion kinase deficiency alters haematopoietic homeostasis to drive tumour metastasis. Nat Commun vol. 5,

Baker A-M, Cereser B, Melton S, Fletcher AG, Rodriguez-Justo M, Tadrous PJ, Humphries A, Elia G et al.(2014). Quantification of crypt and stem cell evolution in the normal and neoplastic human colon. Cell Rep vol. 8, (4) 940-947.

Alexopoulou AN, Ho-Yen CM, Papalazarou V, Elia G, Jones JL, Hodivala-Dilke K(2014). Tumour-associated endothelial-FAK correlated with molecular sub-type and prognostic factors in invasive breast cancer. BMC Cancer vol. 14,

Humphries A, Cereser B, Gay LJ, Miller DSJ, Das B, Gutteridge A, Elia G, Nye E et al.(2013). Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution. Proc Natl Acad Sci U S A vol. 110, (27) E2490-E2499.

Baker M, Reynolds LE, Robinson SD, Lees DM, Parsons M, Elia G, Hodivala-Dilke K(2013). Stromal Claudin14-heterozygosity, but not deletion, increases tumour blood leakage without affecting tumour growth. PLoS One vol. 8, (5)

Galandiuk S, Rodriguez-Justo M, Jeffery R, Nicholson AM, Cheng Y, Oukrif D, Elia G, Leedham SJ et al.(2012). Field cancerization in the intestinal epithelium of patients with Crohn's ileocolitis. Gastroenterology vol. 142, (4) 855-864.e8.

Willis L, Alarcón T, Elia G, Jones JL, Wright NA, Tomlinson IPM, Graham TA, Page KM(2010). Breast cancer dormancy can be maintained by small numbers of micrometastases. Cancer Res vol. 70, (11) 4310-4317.

D'Amico G, Robinson SD, Germain M, Reynolds LE, Thomas GJ, Elia G, Saunders G, Fruttiger M et al.(2010). Endothelial-Rac1 is not required for tumor angiogenesis unless alphavbeta3-integrin is absent. PLoS One vol. 5, (3)

Froeling FEM, Mirza TA, Feakins RM, Seedhar A, Elia G, Hart IR, Kocher HM(2009). Organotypic culture model of pancreatic cancer demonstrates that stromal cells modulate E-cadherin, beta-catenin, and Ezrin expression in tumor cells. Am J Pathol vol. 175, (2) 636-648.

Marchbank T, Elia G, Playford RJ(2009). Intestinal protective effect of a commercial fish protein hydrolysate preparation. Regul Pept vol. 155, (1-3) 105-109.

Fellous TG, McDonald SAC, Burkert J, Humphries A, Islam S, De-Alwis NMW, Gutierrez-Gonzalez L, Tadrous PJ et al.(2009). A methodological approach to tracing cell lineage in human epithelial tissues. Stem Cells vol. 27, (6) 1410-1420.

Fellous TG, Islam S, Tadrous PJ, Elia G, Kocher HM, Bhattacharya S, Mears L, Turnbull DM et al.(2009). Locating the stem cell niche and tracing hepatocyte lineages in human liver. Hepatology vol. 49, (5) 1655-1663.

Gutierrez-Gonzalez L, Deheragoda M, Leedham SJ, Elia G, Shankar A, Imber C, Turnbull DM, Novelli M et al. (2009). HUMAN SMALL INTESTINAL CRYPTS ARE CLONAL, CONTAIN MULTIPLE STEM CELLS AND MUTATED CRYPTS DIVIDE BY FISSION. GUT. vol. 58, A2-A2.

Marchbank T, Elia G, Playford RJ (2009). INTESTINAL PROTECTIVE EFFECT OF A COMMERCIAL FISH PROTEIN HYDROLYSATE PREPARATION. GUT. vol. 58, A46-A47.

Gutierrez-Gonzalez L, Deheragoda M, Elia G, Leedham SJ, Shankar A, Imber C, Jankowski JA, Tumbull DM et al.(2009). Analysis of the clonal architecture of the human small intestinal epithelium establishes a common stem cell for all lineages and reveals a mechanism for the fixation and spread of mutations. J PATHOL vol. 217, (4) 489-496.

Marchbank T, Limdi JK, Mahmood A, Elia G, Playford RJ(2008). Clinical trial: protective effect of a commercial fish protein hydrolysate against indomethacin (NSAID)-induced small intestinal injury. Aliment Pharmacol Ther vol. 28, (6) 799-804.

Wong T, Gammon L, Liu L, Mellerio JE, Dopping-Hepenstal PJC, Pacy J, Elia G, Jeffery R et al.(2008). Potential of fibroblast cell therapy for recessive dystrophic epidermolysis bullosa. J INVEST DERMATOL vol. 128, (9) 2179-2189.

Leedham SJ, Preston SL, McDonald SAC, Elia G, Bhandari P, Poller D, Harrison R, Novelli MR et al.(2008). Individual crypt genetic heterogeneity and the origin of metaplastic glandular epithelium in human Barrett's oesophagus. GUT vol. 57, (8) 1041-1048.

Marchbank T, K Limdi J, Mahmood A, Elia G, J Playford R(2008). Clinical trial: protective effect of a commercial fish protein hydrolysate against indomethacin (NSAID)-induced small intestinal injury. Aliment Pharmacol Ther

Mcdonald SAC, Greaves LC, Gutierrez-Gonzalez L, Rodriguez-Justo M, Deheragoda M, Leedham SJ, Taylor RW, Lee CY et al.(2008). Mechanisms of field cancerization in the human stomach: The expansion and spread of mutated gastric stem cells. GASTROENTEROLOGY vol. 134, (2) 500-510.

Marchbank T, Mahmood A, Fitzgerald AJ, Domin J, Butler M, Goodlad RA, Elia G, Cox HM et al.(2007). Human pancreatic secretory trypsin inhibitor stabilizes intestinal mucosa against noxious agents. Am J Pathol vol. 171, (5) 1462-1473.

Pollard PJ, El-Bahrawy M, Poulsom R, Elia G, Killick P, Kelly G, Hunt T, Jeffery R et al.(2006). Expression of HIF-1alpha, HIF-2alpha (EPAS1), and their target genes in paraganglioma and pheochromocytoma with VHL and SDH mutations. J Clin Endocrinol Metab vol. 91, (11) 4593-4598.

Wortham NC, Alam NA, Barclay E, Pollard PJ, Wagner BE, Manek S, Elia G, Tomlinson IPM(2006). Aberrant expression of apoptosis proteins and ultrastructural aberrations in uterine leiomyomas from patients with hereditary leiomyomatosis and renal cell carcinoma. Fertil Steril vol. 86, (4) 961-971.

WRIGHT NA, ALISON MR, PLAYFORD RJ, POULSOM R, HUNT T, HODIVALA-DILKE K, DIREKZE NC, JEFFERY R et al.(2006). Bone marrow-derived stromal cells express lineage-related messenger RNA species. Cancer Res vol. 66, 1265-1269.

Brittan M, Chance V, Elia G, Poulsom R, Alison MR, MacDonald TT, Wright NA(2005). A regenerative role for bone marrow following experimental colitis: Contribution to neovasculogenesis and myofibroblasts. GASTROENTEROLOGY vol. 128, (7) 1984-1995.

Pollard P, Wortham N, Barclay E, Alam A, Elia G, Manek S, Poulsom R, Tomlinson I(2005). Evidence of increased microvessel density and activation of the hypoxia pathway in tumours from the hereditary leiomyomatosis and renal cell cancer syndrome. J Pathol vol. 205, (1) 41-49.

Brittan M, Chance V, Hunt T, Jeffery RE, Elia G, Poulsom R, Alison MR, MacDonald TT et al. (2004). Bone marrow cells contribute to vascular lineages in colitis. JOURNAL OF PATHOLOGY. vol. 204, 4A-4A.

Preston SL, Oukrif D, Kyriakides A, Elia G, Novelli M, Direkze N, Talbot IC, Tomlinson IP et al. (2004). Modes of growth of colorectal adenomas (flat and polypoid): Evidence against 'top-down' as a major method of expansion. JOURNAL OF PATHOLOGY. vol. 204, 11A-11A.

Xia HHX, Yang Y, Lam SK, Wong WM, Leung SY, Yuen ST, Elia G, Wright NA et al. (2004). Aberrant epithelial expression of trefoil family factor 2 and mucin 6 in Helicobacter pylori infected gastric antrum, incisura, and body and its association with antralisation. JOURNAL OF CLINICAL PATHOLOGY. vol. 57, 861-866.

Brittan M, Chance V, Hunt T, Jeffery R, Elia G, Poulsom R, Alison MR, MacDonald TT et al. (2004). Bone marrow contributes to multiple vascular lineages in colitis. GASTROENTEROLOGY. vol. 126, A128-A128.

Preston SL, Oukrif D, Kyriakides A, Elia G, Novelli M, Direkze NC, Talbot IC, Wright NA (2004). Flat adenomas in the colon originate in monocryptal adenomas and clonally expand by superficial budding without significant "top down" spread. GUT. vol. 53, A20-A20.

Preston SL, Oukrif D, Kyriakides A, Elia G, Talbot IC, Tomlinson IP, Direkze NC, Lipton L et al. (2004). Patterns of beta-catenin staining and downstream targets of beta-catenin/TCF/LEF transcription reveal modes of growth of colorectal adenomas: Evidence against "top down" as a major component of clonal expansion. GUT. vol. 53, A29-A29.

Preston SL, Oukrif D, Kyriakides E, Elia G, Talbot IC, Tomlinson IP, Direkze NC, Lipton L et al. (2004). Patterns of beta-catenin staining and downstream targets of beta-catenin/Tcf/Lef transcription reveal modes of growth of colorectal adenomas: evidence against 'top-down' as a major component of clonal expansion. GASTROENTEROLOGY. vol. 126, A135-A135.

Brittan M, Chance V, Hunt T, Jeffery R, Elia G, Poulsom R, Alison MR, MacDonald TT et al. (2004). Vasculogenesis in colitis: Bone marrow stem cells engraft and transdifferentiate to form vascular cell lineages. GUT. vol. 53, A3-A3.

Preston SL, Wong WM, Chan AOO, Poulsom R, Jeffery R, Goodlad RA, Mandir N, Elia G et al.(2003). Bottom-up histogenesis of colorectal adenomas: Origin in the monocryptal adenoma and initial expansion by crypt fission. CANCER RES vol. 63, (13) 3819-3825.

Sawyer EJ, Poulsom R, Hunt FT, Jeffery R, Elia G, Ellis IO, Ellis P, Tomlinson IPM et al.(2003). Malignant phyllodes tumours show stromal overexpression of c-myc and c-kit. J Pathol vol. 200, (1) 59-64.

Preston SL, Wong WM, Poulsom R, Jeffery R, Goodlad RA, Mandir N, Elia G, Novelli M et al. (2003). Gastrointestinal stem cells: centre stage in the origins of colorectal cancer, of gut cell lineages, and stem cell plasticity. DISEASE PROGRESSION AND CARCINOGENESIS IN THE GASTROINTESTINAL TRACT. vol. 132, 41-67.

Wright NA, Pike CM, Elia G (1990). Ulceration induces a novel epidermal growth factor-secreting cell lineage in human gastrointestinal mucosa. Digestion. vol. 46 Suppl 2, 125-133.