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  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: Dr Trinidad Montero Melendez

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Rinne P, Taylor AW, Montero-Melendez T ( 2023 ) . Editorial: Melanocortins and melanocortin receptors in the regulation of inflammation: mechanisms and novel therapeutic strategies . Frontiers in Immunology vol. 14 ,
Khodeneva N, Sugimoto MA, Davan-Wetton CSA, Montero-Melendez T ( 2023 ) . Melanocortin therapies to resolve fibroblast-mediated diseases . Frontiers in Immunology vol. 13 ,
Garrido-Mesa J, Thomas BL, Dodd J, Spana C, Perretti M, Montero-Melendez T ( 2022 ) . Pro-resolving and anti-arthritic properties of the MC1 selective agonist PL8177 . Frontiers in Immunology vol. 13 ,
Montero-Melendez T, Boesen T, Jonassen TEN ( 2022 ) . Translational advances of melanocortin drugs: Integrating biology, chemistry and genetics . Seminars in Immunology vol. 59 ,
Marques RM, Gonzalez-Nunez M, Walker ME, Gomez EA, Colas RA, Montero-Melendez T, Perretti M, Dalli J ( 2021 ) . Loss of 15-lipoxygenase disrupts Treg differentiation altering their pro-resolving functions . Cell Death & Differentiation vol. 28 , ( 11 ) 3140 - 3160 .
Oggero S, de Gaetano M, Marcone S, Fitzsimons S, Pinto AL, Ikramova D, Barry M, Burke D et al. ( 2021 ) . Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque reactivity . Journal of Extracellular Vesicles vol. 10 , ( 6 )
Davan-Wetton CSA, Pessolano E, Perretti M, Montero-Melendez T ( 2021 ) . Senescence under appraisal: hopes and challenges revisited . Cellular and Molecular Life Sciences vol. 78 , ( 7 ) 3333 - 3354 .
Montero Melendez T, Nagano A, Chelala C, Filer A, Buckley CD, Perretti M ( 2020 ) . Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis . Nature Communications vol. 11 , ( 1 ) Article 745 ,
MONTERO MELENDEZ T ( 2018 ) . MAY INFLAMMATION BE WITH YOU! . Frontiers For Young Minds
Patruno S, Garrido-Mesa J, Romano M, PERRETTI M, MONTERO MELENDEZ T ( 2018 ) . Ligand bias and its association with pro-resolving actions of melanocortin drugs . Frontiers in Pharmacology vol. 9 , ( 919 )
Perretti M, Montero-Melendez T ( 2017 ) . Resolution in an 'over-inflamed' era . Biochemist vol. 39 , ( 4 ) 4 - 7 .
Kaneva MK, Greco KV, Headland SE, Montero-Melendez T, Mori P, Greenslade K, Pitzalis C, Moore A et al. ( 2017 ) . Identification of Novel Chondroprotective Mediators in Resolving Inflammatory Exudates . The Journal of Immunology vol. 198 , ( 7 ) 2876 - 2885 .
Montero-Melendez T, Forfar RAE, Cook JM, Jerman JC, Taylor DL, Perretti M ( 2016 ) . Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3 . Cellular and Molecular Life Sciences vol. 74 , ( 7 ) 1335 - 1345 .
Simeoli R, Raso GM, Pirozzi C, Lama A, Santoro A, Russo R, Montero‐Melendez T, Canani RB et al. ( 2016 ) . An orally administered butyrate‐releasing derivative reduces neutrophil recruitment and inflammation in dextran sulphate sodium‐induced murine colitis . British Journal of Pharmacology vol. 174 , ( 11 ) 1484 - 1496 .
Madeira MFM, Queiroz-Junior CM, Montero-Melendez T, Werneck SMC, Correa JD, Soriani FM, Garlet GP, Souza DG et al. ( 2016 ) . Melanocortin agonism as a viable strategy to control alveolar bone loss induced by oral infection . The FASEB Journal
MONTERO MELENDEZ T, Buckley CD, Filer A, Turner JD, Perretti M ( 2016 ) . TARGETING SYNOVIAL FIBROBLASTS WITH MELANOCORTIN DRUGS . ANNALS OF THE RHEUMATIC DISEASES . Conference: Annual European Congress of Rheumatology EULAR 2016 vol. 75 , 923 - 923 .
Perretti M, Leroy X, Bland EJ, Montero-Melendez T ( 2015 ) . Resolution Pharmacology: Opportunities for Therapeutic Innovation in Inflammation . Trends in Pharmacological Sciences vol. 36 , ( 11 ) 737 - 755 .
Haas R, Smith J, Rocher-Ros V, Nadkarni S, Montero-Melendez T, D’Acquisto F, Bland EJ, Bombardieri M et al. ( 2015 ) . Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions . PLOS Biology vol. 13 , ( 7 )
Montero-Melendez T, Gobbetti T, Cooray SN, Jonassen TE, Perretti M ( 2015 ) . Biased agonism as a novel strategy to harness the proresolving properties of melanocortin receptors without eliciting melanogenic effects . J Immunol vol. 194 , ( 7 ) 3381 - 3388 .
Montero-Melendez T ( 2015 ) . ACTH: The forgotten therapy . Seminars in Immunology vol. 27 , ( 3 ) 216 - 226 .
Montero-Melendez T, Madeira MFM, Norling LV, Alsam A, Curtis MA, da Silva TA, Perretti M ( 2014 ) . Association between periodontal disease and inflammatory arthritis reveals modulatory functions by melanocortin receptor type 3 . Am J Pathol vol. 184 , ( 8 ) 2333 - 2341 .
Montero-Melendez T, Perretti M ( 2014 ) . Gapdh gene expression is modulated by inflammatory arthritis and is not suitable for qPCR normalization . Inflammation vol. 37 , ( 4 ) 1059 - 1069 .
Montero-Melendez T, Perretti M ( 2014 ) . Connections in pharmacology: innovation serving translational medicine . Drug Discov Today vol. 19 , ( 7 ) 820 - 823 .
Haas R, Smith J, Rocher-Ros V, Montero-Melendez T, D'Acquisto F, Bland EJ, Bombardieri M, Pitzalis C et al. ( 2014 ) . How the microenvironment contributes to the establishment of chronic inflammatory diseases: lactate regulates metabolic and pro-inflammatory circuits in control of T cell migration and functions . IMMUNOLOGY vol. 143 , 151 - 151 .
Dalli J, Norling LV, Montero-Melendez T, Federici Canova D, Lashin H, Pavlov AM, Sukhorukov GB, Hinds CJ et al. ( 2014 ) . Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis . EMBO Mol Med vol. 6 , ( 1 ) 27 - 42 .
Cooray SN, Gobbetti T, Montero-Melendez T, McArthur S, Thompson D, Clark AJL, Flower RJ, Perretti M ( 2013 ) . Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses . Proc Natl Acad Sci U S A vol. 110 , ( 45 ) 18232 - 18237 .
Dalli J, Montero-Melendez T, Norling LV, Yin X, Hinds C, Haskard D, Mayr M, Perretti M ( 2013 ) . Heterogeneity in neutrophil microparticles reveals distinct proteome and functional properties . Mol Cell Proteomics vol. 12 , ( 8 ) 2205 - 2219 .
Montero-Melendez T, Dalli J, Perretti M ( 2013 ) . Gene expression signature-based approach identifies a pro-resolving mechanism of action for histone deacetylase inhibitors . Cell Death Differ vol. 20 , ( 4 ) 567 - 575 .
Calleja MA, Vieites JM, Montero-Meléndez T, Torres MI, Faus MJ, Gil A, Suárez A ( 2013 ) . The antioxidant effect of β-caryophyllene protects rat liver from carbon tetrachloride-induced fibrosis by inhibiting hepatic stellate cell activation . Br J Nutr vol. 109 , ( 3 ) 394 - 401 .
Rhodes DH, Pini M, Castellanos KJ, Montero-Melendez T, Cooper D, Perretti M, Fantuzzi G ( 2013 ) . Adipose tissue-specific modulation of galectin expression in lean and obese mice: evidence for regulatory function . Obesity (Silver Spring) vol. 21 , ( 2 ) 310 - 319 .
Schutters K, Kusters DHM, Chatrou MLL, Montero-Melendez T, Donners M, Deckers NM, Krysko DV, Vandenabeele P et al. ( 2013 ) . Cell surface-expressed phosphatidylserine as therapeutic target to enhance phagocytosis of apoptotic cells . Cell Death Differ vol. 20 , ( 1 ) 49 - 56 .
Ahmed TJ, Montero-Melendez T, Perretti M, Pitzalis C ( 2013 ) . Curbing Inflammation through Endogenous Pathways: Focus on Melanocortin Peptides . Int J Inflam vol. 2013 ,
Montero-Meléndez T, Llor X, García-Planella E, Perretti M, Suárez A ( 2013 ) . Identification of novel predictor classifiers for inflammatory bowel disease by gene expression profiling . PLoS One vol. 8 , ( 10 )
Perretti M, Dalli J, Norling LV, Montero-Melendez T, Hinds C ( 2013 ) . Neutrophil Microparticles are heterogenous in content and function . FASEB JOURNAL . vol. 27 ,
Al-Kashi A, Montero-Melendez T, Moradi-Bidhendi N, Gilligan JP, Mehta N, Perretti M ( 2013 ) . The calcitonin and glucocorticoids combination: mechanistic insights into their class-effect synergy in experimental arthritis . PLoS One vol. 8 , ( 2 )
de Lima CB, Tamura EK, Montero-Melendez T, Palermo-Neto J, Perretti M, Markus RP, Farsky SHP ( 2012 ) . Actions of translocator protein ligands on neutrophil adhesion and motility induced by G-protein coupled receptor signaling . Biochem Biophys Res Commun vol. 417 , ( 2 ) 918 - 923 .
Dalli J, Montero-Melendez T, McArthur S, Perretti M ( 2012 ) . Annexin A1 N-terminal derived Peptide ac2-26 exerts chemokinetic effects on human neutrophils . Front Pharmacol vol. 3 ,
Vessillier S, Adams G, Montero-Melendez T, Jones R, Seed M, Perretti M, Chernajovsky Y ( 2012 ) . Molecular engineering of short half-life small peptides (VIP, αMSH and γ₃MSH) fused to latency-associated peptide results in improved anti-inflammatory therapeutics . Ann Rheum Dis vol. 71 , ( 1 ) 143 - 149 .
Patel HB, Montero-Melendez T, Greco KV, Perretti M ( 2011 ) . Melanocortin receptors as novel effectors of macrophage responses in inflammation . Frontiers in Immunology vol. 2 , Article 41 , 1 - 6 .
Montero-Melendez T, Patel HB, Seed M, Nielsen S, Jonassen TEN, Perretti M ( 2011 ) . The melanocortin agonist AP214 exerts anti-inflammatory and proresolving properties . Am J Pathol vol. 179 , ( 1 ) 259 - 269 .
Rhodes D, Pini M, Montero-Melendez T, Perretti M, Fantuzzi G ( 2011 ) . EXPRESSION OF ANNEXIN A1 IN ADIPOSE TISSUE IS DISSOCIATED FROM MACROPHAGE INFILTRATION DURING DEVELOPMENT OF OBESITY IN MICE . INFLAMMATION RESEARCH . vol. 60 , 261 - 261 .
Montero-Melendez T, Jonassen T, Seed M, Perretti M ( 2011 ) . MC3 AGONISTS AS NOVEL PRO-RESOLVING THERAPEUTICS . INFLAMMATION RESEARCH . vol. 60 , 269 - 269 .
Greco KV, Montero-Melendez T, Patel H, Perretti M ( 2011 ) . MELANOCORTIN RECEPTOR AGONISTS ARE NOVEL CHONDROPROTECTIVE THERAPEUTICS . INFLAMMATION RESEARCH . vol. 60 , 273 - 273 .
Vessillier S, Adams G, Montero-Melendez T, Jones R, Seed MP, Perretti M, Chernajovsky Y ( 2011 ) . MOLECULAR ENGINEERING OF SHORT HALF LIFE SMALL PEPTIDES (VIP, alpha MSH AND gamma 3MSH) INTO LATENT ASSOCIATED PEPTIDE (LAP) RESULTS IN TARGETED ANTI-INFLAMMATORY AND ANTI-RHEUMATIC THERAPEUTICS . INFLAMMATION RESEARCH . vol. 60 , 43 - 43 .
Montero-Melendez T, Patel HB, Perretti M ( 2011 ) . Role of melanocortin receptors in the regulation of gouty inflammation . Curr Rheumatol Rep vol. 13 , ( 2 ) 138 - 145 .
Patel HB, Montero-Melendez T, Greco KV, Perretti M ( 2011 ) . Melanocortin receptors as novel effectors of macrophage responses in inflammation . Front Immunol vol. 2 ,
Renshaw D, Montero-Melendez T, Dalli J, Kamal A, Brancaleone V, D'Acquisto F, Cirino G, Perretti M ( 2010 ) . Downstream gene activation of the receptor ALX by the agonist annexin A1 . PLoS One vol. 5 , ( 9 )
Suarez Garcia A, MONTERO MELENDEZ T ( 2010 ) . Tratado de Nutrición. 2a ed. Tomo I: Bases Fisiológicas y Bioquímicas de la Nutrición.(Encuadernación: Rústica) . Tratado de Nutrición. 2a ed. Tomo I: Bases Fisiológicas y Bioquímicas de la Nutrición.(Encuadernación: Rústica) , Editors: Hernandez, AG , Ed. Médica Panamericana
Patel HB, Leoni G, MONTERO MELENDEZ T, Sampaio A, Perretti M ( 2010 ) . Melanocortins . Melanocortins , Editors: Catania, A , Springer Verlag
Patel HB, Leoni G, Montero-Melendez T, Sampaio AL, Perretti M ( 2010 ) . Melanocortin control of cell trafficking in vascular inflammation . Melanocortins: Multiple Actions and Therapeutic Potential. Advances in Experimental Medicine and Biology, vol 681 , Editors: ? , vol. 681 ,
Gila A, Aguilera CM, Tofe I, Suarez A, Montero T, Gil-Campos M, Canete R ( 2008 ) . Altered gene expresión associated with lipid metabolism in adipose tissue of obese children . Obesity Reviews . Editors: ? , Conference: 18th Annual Meeting of the European Childhood Obesity Group ( Porto (Portugal) ) from: 05/06/2008 to: 07/06/2008 , vol. 9, Suppl.2 , 17 - 18 .
Montero T, Llor X, Suarez A ( 2008 ) . Gene-expression signature-based approach identifies pro-apoptotic compounds in Caco-2 cell line . Gastroenterology . Editors: ? , Conference: Digestive Diseases Week 2008 ( San Diego (USA) ) vol. 4, Suppl.1 ,
Gil A, Aguilera CM, Montero T, Suarez A, Tofe I, Gil-Campos M, Canete R ( 2007 ) . Altered Gene Expression Associated with Inflammation in Adipose Tissue of Obese Children . International Journal of Obesity . Editors: ? , Conference: 17th Annual Meeting of the European Chilhood Obesity Group (ECOG) ( Athens (Greece) )
Montero T, Vieites JM, Llor X, Martinez O, Sanchez de Medina F, Gil A, Gassull MA, Suarez A ( 2007 ) . Comparative genomic analysis of rat IBD models identifies new genes and biological processes as potential therapeutic targets . Gastroenterology . Editors: ? , Conference: Digestive Diseases Week 2007 ( Washington D.C. (USA) ) vol. 4, Suppl.1 ,
Montero T, Vieites JM, Sanchez de Medina F, Llor X, Martinez O, Gassull MA, Suarez A ( 2007 ) . Genomic expression analysis reveals new molecular and cellular events involved in the pathogenesis of DSS-induced colitis . Gastroenterology . Editors: ? , Conference: Digestive Diseases Week 2007 ( Washington D.C. (USA) ) vol. 4, Suppl.1 ,
Montero T, Vieites JM, Llor X, Marinez O, Sanchez de Medina F, Suarez A ( 2006 ) . A comparative genomic perspective on murine inflammatory bowel disease models . Gastroenterology . Editors: ? , Conference: Digestive Diseases Week 2006 ( Los Angeles (USA) ) vol. 4, Suppl.2 ,
Montero T, Vieites JM, Llor X, Marinez O, Sanchez de Medina F, Suarez A ( 2006 ) . Análisis genómico comparativo de varios modelos animales de Enfermedad Inflamatoria Intestinal . Editors: ? , Conference: Digestive Diseases Week: LXV Congress of the Spanish Society of Digestive Pathology ( Granada (Spain) ) vol. 98, Suppl.1 ,
Montero T, Aguilera CM, Suarez A, Gomez-Llorente C, Tofe I, Gomez E, Gil M, Canete R et al. ( 2006 ) . Changes in the Expression of Genes Related to Insulin Signaling in Adipose Tissue of Obese Children . International Journal of Obesity . Editors: ? , Conference: 16th Annual Meeting of the European Chilhood Obesity Group (ECOG) ( Rzeszów (Poland) ) vol. 30, Suppl.2S , S1 - S43 .
Montero T, Martinez O, Vieites JM, Llor X, Gassull MA, Suarez MD, Zarzuelo A, Suarez A et al. ( 2006 ) . Efectos de la sulfasalazina en el perfil de expresión génica de la colitis inducida por ácido trinitrobencenosulfónico en ratas . Spanish Journal of Digestive Diseases . Editors: ? , Conference: Digestive Diseases Week: LXV Congress of the Spanish Society of Digestive Pathology ( Granada (Spain) ) vol. 98, Suppl.1 ,
Martinez O, Montero T, Suarez A, Llor X, Vieites JM, Suarez MD, Zarzuelo A, Sanchez de Medina F ( 2006 ) . Effect of sulfasalazine on the colonic transcriptome in rat TNBS colitis . Gastroenterology . Editors: ? , Conference: Digestive Diseases Week 2007 ( Washington D.C. (USA) ) vol. 4, Suppl.1 ,
Vieites JM, de la Torre R, Ortega MA, Montero-Melendez T, Peco JM, Sanchez-Pozo A, Gil A, Suarez A ( 2003 ) . Characterization of human cd200 glycoprotein receptor gene located on chromosome 3q12-13 . Gene vol. 311 , 99 - 104 .
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