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Publications:  Dr James Whiteford

Godmann L, Bollmann M, Korb-Pap A, König U, Sherwood J, Beckmann D, Mühlenberg K, Echtermeyer F et al.(2020). Antibody-mediated inhibition of syndecan-4 dimerisation reduces interleukin (IL)-1 receptor trafficking and signalling. Ann Rheum Dis vol. 79, (4) 481-489.
Arokiasamy S, Balderstone MJM, De Rossi G, Whiteford JR(2020). Syndecan-3 in Inflammation and Angiogenesis. Frontiers in Immunology vol. 10,
De Rossi G, Vahatupa M, Cristante E, Liyanage SE, May U, Uusitalo-Jarvinen H, Bainbridge JW, Jarvinen TAH et al. (2019). A novel role for Syndecan-4 in neovascular eye diseases. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 100, A38-A38.
Whiteford JR, Arokiasamy S, De Rossi G(2019). Translating the matrix. British Journal of Pharmacology vol. 176, (1) 3-4.
Vahatupa M, De Rossi G, Jarvinen TAH, Uusitalo-Jarvinen H, Whiteford JR (2018). Sdc4 deficiency leads to reduced VEGFA induced pathological ocular angiogenesis. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. vol. 59,
Eldridge SE, Thomas BL, Shanmuganathan K, Strachan D, Ali A, Thorup A-S, Caxaria S, Nalesso G et al. (2017). AGRIN INHIBITS CANONICAL WNT SIGNALLING THROUGH LRP4. OSTEOARTHRITIS AND CARTILAGE. vol. 25, S165-S165.
De Rossi G, Cristante E, Bland E, Bainbridge JW, Whiteford JR (2017). A syndecan-derived peptide for the treatment of Wet age-related macular degeneration. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 98, A15-A15.
De Rossi G, Cristante E, Vahatupa M, Liyanage SE, May U, Pellinen L, Uusitalo-Jarvinen H, Bainbridge JW et al. (2017). VEGFA-driven pathological angiogenesis requires the proteoglycan syndecan-4. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 98, A14-A15.
Rauzi F, Kirkby NS, Edin ML, Whiteford J, Zeldin DC, Mitchell JA, Warner TD(2016). Aspirin inhibits the production of proangiogenic 15(S)-HETE by platelet cyclooxygenase-1. The FASEB Journal
WHITEFORD J, Ma B, Woodfin, Nourshargh(2016). Underlying chronic inflammation alters the profile and mechanisms of acute neutrophil recruitment. Journal of Pathology
Reglerol N, Beall R, Cabrera C, Pickworthl C, Golding M, Whiteford J, Nightingale T, Imhof B et al. (2016). JAM-C deficiency primes endothelial cells for a pro-inflammatory state. FASEB JOURNAL. vol. 30,
Hawkins KE, Joy S, Delhove JMKM, Kotiadis VN, Fernandez E, Fitzpatrick LM, Whiteford JR, King PJ et al.(2016). NRF2 Orchestrates the Metabolic Shift during Induced Pluripotent Stem Cell Reprogramming. Cell Reports vol. 14, (8) 1883-1891.
Woodfin A, Beyrau M, Voisin M-B, Ma B, Whiteford JR, Hordijk PL, Hogg N, Nourshargh S(2016). ICAM-1-expressing neutrophils exhibit enhanced effector functions in murine models of endotoxemia. Blood vol. 127, (7) 898-907.
Whiteford JR, De Rossi G, Woodfin A(2016). Mutually Supportive Mechanisms of Inflammation and Vascular Remodeling. vol. 326, 201-278.
Madalli S, Beyrau M, Whiteford J, Duchene J, Nandhra IS, Patel NSA, Motwani MP, Gilroy DW et al.(2015). Sex-specific regulation of chemokine Cxcl5/6 controls neutrophil recruitment and tissue injury in acute inflammatory states. Biology of Sex Differences vol. 6, (1)
Kay E, Gomez-Garcia L, Woodfin A, Scotland RS, Whiteford JR(2015). Sexual dimorphisms in leukocyte trafficking in a mouse peritonitis model. J Leukoc Biol vol. 98, (5) 805-817.
Gopinathan G, Milagre C, Pearce OMT, Reynolds LE, Hodivala-Dilke K, Leinster DA, Zhong H, Hollingsworth RE et al.(2015). Interleukin-6 stimulates defective angiogenesis. Cancer Research vol. 75, (15) 3098-3107.
Rauzi F, Kirkby N, Edin M, Zeldin D, Whiteford J, Mitchell J, Warner T (2015). 15(S)-HETE is a pro-angiogenic factor produced by platelets through COX-1. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. vol. 13, 225-225.
Ma B, Whiteford JR, Nourshargh S, Woodfin A(2015). Angiogenesis associated macrophages support elevated acute inflammatory responses. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION vol. 45, 48-48.
De Rossi G, Whiteford JR(2014). Syndecans in angiogenesis and endothelial cell biology. Biochemical Society Transactions vol. 42, (6) 1643-1646.
Kay E, Scotland RS, Whiteford JR (2014). Sex-differences in classical monocyte recruitment during inflammation. CYTOKINE. vol. 70, 50-50.
De Rossi G, Evans AR, Kay E, Woodfin A, McKay TR, Nourshargh S, Whiteford JR(2014). Shed syndecan-2 inhibits angiogenesis. J Cell Sci vol. 127, (Pt 21) 4788-4799.
De Rossi G, Nourshargh S, Whiteford JR(2014). Shed syndecan-2 is a regulator of angiogenesis. ANGIOGENESIS vol. 17, (3) 756-756.
De Rossi G, Nourshargh S, Whiteford JR(2014). Syndecan-4 is required for VEGF-induced angiogenesis. ANGIOGENESIS vol. 17, (3) 715-715.
Kay E, Nourshargh S, Scotland RS, Whiteford JR(2014). Sex-differences in classical monocyte recruitment during inflammation. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION vol. 44, 14-15.
Evans AR, De Rossi G, Woodfin A, Kay E, Leese AJ, Nourshargh S, Whiteford JR(2014). The role of syndecan-4 in inflammation. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION vol. 44, 23-23.
Kay E, Scotland RS, Whiteford JR(2014). Toll-like receptors: Role in inflammation and therapeutic potential. Biofactors vol. 40, (3) 284-294.
Halai K, Whiteford J, Ma B, Nourshargh S, Woodfin A(2014). ICAM-2 facilitates luminal interactions between neutrophils and endothelial cells in vivo. J Cell Sci vol. 127, (Pt 3) 620-629.
Leinster DA, Colom B, Whiteford JR, Ennis DP, Lockley M, McNeish IA, Aurrand-Lions M, Chavakis T et al.(2013). Endothelial cell junctional adhesion molecule C plays a key role in the development of tumors in a murine model of ovarian cancer. FASEB J vol. 27, (10) 4244-4253.
De Rossi G, Whiteford JR(2013). Novel insight into the biological functions of syndecan ectodomain core proteins. Biofactors vol. 39, (4) 374-382.
De Rossi G, Scotland R, Whiteford J(2013). Critical Factors in Measuring Angiogenesis Using the Aortic Ring Model. J Genet Syndr Gene Ther vol. 4, (5)
De Rossi G, Nourshargh S, Whiteford JR (2013). Syndecan extracellular core proteins have anti-angiogenic properties. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 94, A44-A45.
De Rossi G, Whiteford JR(2013). A novel role for syndecan-3 in angiogenesis. F1000Res vol. 2,
WHITEFORD J, Xian X, Couchman JR(2012). Syndecans as receptors for pericellular molecules. Extracellular Matrix: Pathobiology and Signaling, Editors: Karamanos, N, Walter de Gruyter
Proebstl D, Voisin MB, Woodfin A, Whiteford J, D'Acquisto F, Jones GE, Rowe D, Nourshargh S(2012). Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo. J Exp Med vol. 209, (6) 1219-1234.
Whiteford JR, Xian X, Chaussade C, Vanhaesebroeck B, Nourshargh S, Couchman JR(2011). Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148. Molecular Biology of the Cell vol. 22, (19) 3609-3624.
Schaefer L, Evan L, Whiteford J, Dyer D, Rowan D (2011). Cell signalling in inflammation. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 92, A6-A7.
Whiteford JR, Xian X, Couchman JR (2011). Syndecan-2 core protein directly interacts with the protein tyrosine phosphatase CD148/PTPRJ to promote integrin-mediated adhesion. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 92, A13-A14.
Whiteford JR, Xian X, Couchman JR (2010). Cell adhesion to the adhesion regulatory domains of syndecan-2 and-4 require the protein tyrosine receptor CD148/PTPRJ. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 91, A26-A26.
Gopal S, Bober A, Whiteford JR, Multhaupt H, Yoneda A, Couchman JR(2010). Heparan sulfate chain valency controls syndecan-4 function in cell adhesion. Journal of Biological Chemistry vol. 285, 14247-14258.
Multhaupt HAB, Yoneda A, Whiteford JR, Oh E-S, Lee W, Couchman JR(2009). Syndecan signaling: when, where and why?. J Physiol Pharmacol vol. 60 Suppl 4, 31-38.
Okina E, Manon-Jensen T, Whiteford JR, Couchman JR(2009). Syndecan proteoglycan contributions to cytoskeletal organization and contractility. Scand J Med Sci Sports vol. 19, (4) 479-489.
Whiteford JR, Ko S, Lee W, Couchman JR(2008). Structural and cell adhesion properties of zebrafish syndecan-4 are shared with higher vertebrates. J Biol Chem vol. 283, (43) 29322-29330.
Lacroix H, Whiteford JR, Spanu PD(2008). Localization of Cladosporium fulvum hydrophobins reveals a role for HCf-6 in adhesion. FEMS Microbiol Lett vol. 286, (1) 136-144.
Whiteford J, Couchman J (2008). Integrin mediated cell adhesion to the syndecan-4 ectodomain requires N-glycosylation and phosphatases. FASEB JOURNAL. vol. 22,
Alexopoulou AN, Couchman JR, Whiteford JR(2008). The CMV early enhancer/chicken beta actin (CAG) promoter can be used to drive transgene expression during the differentiation of murine embryonic stem cells into vascular progenitors. BMC Cell Biology vol. 9, (2)
Whiteford JR, Behrends V, Kirby H, Kusche-Gullberg M, Muramatsu T, Couchman JR(2007). Syndecans promote integrin-mediated adhesion of mesenchymal cells in two distinct pathways. Exp Cell Res vol. 313, (18) 3902-3913.
Whiteford JR, Couchman JR(2006). A conserved NXIP motif is required for cell adhesion properties of the syndecan-4 ectodomain. J Biol Chem vol. 281, (43) 32156-32163.
Koo BK, Han I, Mortier E, Zimmermann P, Whiteford JR, Couchman JR, Oh ES, Lee W (2006). Structural basis of cell adhesion signalling of syndecan-4 proteoglycan as a cell surface receptor. FEBS JOURNAL. vol. 273, 90-90.
Koo B-K, Jung YS, Shin J, Han I, Mortier E, Zimmermann P, Whiteford JR, Couchman JR et al.(2006). Structural basis of syndecan-4 phosphorylation as a molecular switch to regulate signaling. J Mol Biol vol. 355, (4) 651-663.
Whiteford JR, Lacroix H, Talbot NJ, Spanu PD(2004). Stage-specific cellular localisation of two hydrophobins during plant infection by the pathogenic fungus Cladosporium fulvum. Fungal Genet Biol vol. 41, (6) 624-634.
Johnson H, Whiteford JR, Eckert SE, Spanu PD(2003). Production and secretion of Aspergillus nidulans catalase B in filamentous fungi driven by the promoter and signal peptide of the Cladosporium fulvum hydrophobin gene hcf-1. Curr Genet vol. 44, (3) 155-163.
Whiteford JR, Spanu PD(2002). Hydrophobins and the interactions between fungi and plants. Mol Plant Pathol vol. 3, (5) 391-400.
Whiteford JR, Spanu PD(2001). The hydrophobin HCf-1 of Cladosporium fulvum is required for efficient water-mediated dispersal of conidia. Fungal Genet Biol vol. 32, (3) 159-168.
Whiteford JR, Wilson C, Tiwana H, Ebringer A(2000). Genetic diversity in Proteus mirabilis isolates found in the urinary tract of rheumatoid arthritis patients. J INFECTION vol. 41, (3) 245-248.
Whiteford JR, Wood DA, Thurston CF(2000). Characterisation of xylanases produced in liquid and compost cultures of the cultivated mushroom Agaricus bisporus. MYCOLOGICAL RESEARCH vol. 104, 810-819.
Whiteford JR, Thurston CF(2000). The molecular genetics of cultivated mushrooms. Adv Microb Physiol vol. 42, 1-23.
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